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https://www.readbyqxmd.com/read/29714501/automatic-spectral-imaging-protocol-and-iterative-reconstruction-for-radiation-dose-reduction-in-typical-hepatic-hemangioma-computed-tomography-with-reduced-iodine-load-a-preliminary-study
#1
Wei Li, Aiyin Li, Bin Wang, Xiuyuan Niu, Xin Cao, Xinyi Wang, Hao Shi
OBJECTIVES: To evaluate the effect of automatic spectral imaging protocol selection (ASIS) and adaptive statistical iterative reconstruction (ASiR) technique in the reduction of radiation and contrast medium dose in typical hepatic hemangioma (HH) dual-energy spectral CT (DEsCT). METHODS: 62 patients with suspected HH were randomly divided into two groups equally: group A, conventional 120-kVp CT with standard iodine load; group B, DEsCT with ASIS technique and reduced iodine load, two sets of monochromatic spectral images were reconstructed: 69keV level with 30% ASiR (group B1 ) and 52keV level with 50%ASiR (group B2 )...
May 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29614089/hippocampal-protein-kinase-d1-is-necessary-for-dhpg-induced-learning-and-memory-impairments-in-rats
#2
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
BACKGROUND: Understanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons by application of (S)-3,5-Dihydroxyphenylglycine (DHPG) causes the regulated internalization of N-methyl-D-aspartate receptors (NMDARs), which subsequently activates protein kinase D1 (PKD1). Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs...
2018: PloS One
https://www.readbyqxmd.com/read/29588171/mechanism-of-adrenomedullin-2-intermedin-mediated-vasorelaxation-in-rat-main-pulmonary-artery
#3
Gokcen Telli, Yasemin Erac, Banu Cahide Tel, Bulent Gumusel
Adrenomedullin 2/intermedin (AM2/IMD) is a member of calcitonin related gene peptide family and an important nitric oxide mediated vasorelaxant in various vascular beds. However, the mechanism of post receptor-interaction is not clear and may differ depending on tissue type and species. In this study, we aimed to investigate the exact mechanism and the role of BKCa and calcium channels on the vasorelaxant effect of AM2/IMD in rat PA. Changes in the AM2/IMD-mediated vasorelaxation were evaluated in the presence of various inhibitors...
March 24, 2018: Peptides
https://www.readbyqxmd.com/read/29571569/life-cycle-assessment-of-integrated-solid-state-anaerobic-digestion-and-composting-for-on-farm-organic-residues-treatment
#4
Yangyang Li, Ashish Manandhar, Guoxue Li, Ajay Shah
Driven by the gradual changes in the structure of energy consumption and improvements of living standards in China, the volume of on-farm organic solid waste is increasing. If untreated, these unutilized on-farm organic solid wastes can cause environmental problems. This paper presents the results of a life cycle assessment to compare the environmental impacts of different on-farm organic waste (which includes dairy manure, corn stover and tomato residue) treatment strategies, including anaerobic digestion (AD), composting, and AD followed by composting...
March 20, 2018: Waste Management
https://www.readbyqxmd.com/read/29561802/selection-and-characterization-of-single-stranded-dna-aptamers-binding-human-b-cell-surface-protein-cd20-by-cell-selex
#5
Mansoureh Haghighi, Hossein Khanahmad, Abbasali Palizban
The B-lymphocyte antigen (CD20) is a suitable target for single-stranded (ss) nucleic acid oligomer (aptamers). The aim of study was selection and characterization of a ssDNA aptamer against CD20 using Cell-Systematic Evolution of Ligands by Exponential Enrichment (Cell-SELEX). The cDNA clone of CD20 (pcDNA-CD20) was transfected to human embryonic kidney (HEK293T) cells. Ten rounds of Cell-SELEX was performed on recombinant HEK-CD20 cells. The final eluted ssDNA pool was amplified and ligated in T/A vector for cloning...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29524301/robust-optimization-in-lung-treatment-plans-accounting-for-geometric-uncertainty
#6
REVIEW
Xin Zhang, Yi Rong, Steven Morrill, Jian Fang, Ganesh Narayanasamy, Edvaldo Galhardo, Sanjay Maraboyina, Christopher Croft, Fen Xia, Jose Penagaricano
Robust optimization generates scenario-based plans by a minimax optimization method to find optimal scenario for the trade-off between target coverage robustness and organ-at-risk (OAR) sparing. In this study, 20 lung cancer patients with tumors located at various anatomical regions within the lungs were selected and robust optimization photon treatment plans including intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) plans were generated. The plan robustness was analyzed using perturbed doses with setup error boundary of ±3 mm in anterior/posterior (AP), ±3 mm in left/right (LR), and ±5 mm in inferior/superior (IS) directions from isocenter...
March 10, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29523712/the-adaptor-protein-3-complex-mediates-pollen-tube-growth-by-coordinating-vacuolar-targeting-and-organization
#7
Qiang-Nan Feng, Xin Liang, Sha Li, Yan Zhang
Pollen tube growth is an essential step for successful plant reproduction. Vacuolar trafficking and dynamic organization are important for pollen tube growth; however, the key proteins involved in these processes are not well understood. Here, we report that the ADAPTOR PROTEIN-3 (AP-3) complex and its tonoplast cargo PROTEIN S-ACYL TRANSFERASE10 (PAT10) are critical for pollen tube growth in Arabidopsis ( Arabidopsis thaliana ). AP-3 is a heterotetrameric protein complex consisting of four subunits, δ, β, µ, and σ...
May 2018: Plant Physiology
https://www.readbyqxmd.com/read/29505103/interventions-for-eye-movement-disorders-due-to-acquired-brain-injury
#8
REVIEW
Fiona J Rowe, Kerry Hanna, Jennifer R Evans, Carmel P Noonan, Marta Garcia-Finana, Caroline S Dodridge, Claire Howard, Kathryn A Jarvis, Sonia L MacDiarmid, Tallat Maan, Lorraine North, Helen Rodgers
BACKGROUND: Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties. A wide range of interventions exist that have potential to alleviate or ameliorate these symptoms. There is a need to evaluate the effectiveness of these interventions and the timing of their implementation. OBJECTIVES: We aimed to assess the effectiveness of any intervention and determine the effect of timing of intervention in the treatment of strabismus, gaze deficits and nystagmus due to acquired brain injury...
March 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29476722/mir-51-regulates-gabaergic-synapses-by-targeting-rab-gef-glo-4-and-lysosomal-trafficking-related-glo-ap-3-pathway-in-caenorhabditis-elegans
#9
Shuai Zhang, Zhibin Fan, Ping Qiao, Yinsuo Zhao, Yanan Wang, Da Jiang, Xiangming Wang, Xiaojuan Zhu, Yu Zhang, Baiqu Huang, Jun Lu, Xiaoxue Li
A deficit of GABA (γ-aminobutyric acid) transmission will lead to epilepsy and other cognitive disorders. Recent evidence has shown that neuronal miRNAs affect various synapses, including GABAergic synapses. However, the miRNAs that control GABAergic synapses remain not fully understood. Here, we identified miR-51, a member of Caenorhabditis elegans miR-99/100 family, as a key regulator of GABAergic synapses. Loss of mir-51 increased PTZ (Pentylenetetrazole) and aldicarb hypersensitivities, and decreased the number of GABAergic synapses and abundance of GABAA receptors...
April 1, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29476203/first-experience-with-zero-fluoroscopic-ablation-for-supraventricular-tachycardias-using-a-novel-impedance-and-magnetic-field-based-mapping-system
#10
Katie A Walsh, Joseph Galvin, John Keaney, Edward Keelan, Gabor Szeplaki
AIMS: Zero- and near-zero-fluoroscopic ablation techniques reduce the harmful effects of ionizing radiation during invasive electrophysiology procedures. We aimed to test the feasibility and safety of a zero-fluoroscopic strategy using a novel integrated magnetic and impedance-based electroanatomical mapping system for radiofrequency ablation (RFA) of supraventricular tachycardias (SVTs). METHODS: We retrospectively studied 92 consecutive patients undergoing electrophysiology studies with/without RFA for supraventricular tachycardia (SVT) performed by a single operator at a single center...
February 23, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29411478/a-subunit-of-the-hops-endocytic-tethering-complex-fgvps41-is-important-for-fungal-development-and-plant-infection-in-fusarium-graminearum
#11
Bing Li, Xin Dong, Xinrui Li, Huaigu Chen, Haifeng Zhang, Xiaobo Zheng, Zhengguang Zhang
The signals by which eukaryotic cells communicate with the environment are usually mediated by vesicle trafficking to be attenuated or terminated. However, vesicle trafficking-mediated signal transmission during interactions between pathogens and host plants is poorly understood. Here, we identified and characterized the vacuole sorting protein FgVps41, which is the yeast HOPS tethering complex subunit Vps41 homolog in Fusarium graminearum. Targeted gene deletion demonstrated that FgVps41 is important for vegetative growth, asexual/sexual development, conidial morphology, plant infection and deoxynivalenol production...
April 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29351467/from-ionic-to-cellular-variability-in-human-atrial-myocytes-an-integrative-computational-and-experimental-study
#12
Anna Muszkiewicz, Xing Liu, Alfonso Bueno-Orovio, Brodie A J Lawson, Kevin Burrage, Barbara Casadei, Blanca Rodriguez
Variability refers to differences in physiological function between individuals, which may translate into different disease susceptibility and treatment efficacy. Experiments in human cardiomyocytes face wide variability and restricted tissue access; under these conditions computational models are a useful complementary tool. We conducted a computational and experimental investigation in cardiomyocytes isolated from samples of the right atrial appendage of patients undergoing cardiac surgery to evaluate the impact of variability in action potentials (APs) and sub-cellular ionic densities on calcium transient dynamics...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29228863/parallel-evaluation-of-two-potassium-channel-blockers-in-restoring-conduction-in-mechanical-spinal-cord-injury-in-rat
#13
Jessica Page, Jonghyuck Park, Zhe Chen, Peng Cao, Riyi Shi
Myelin damage is a hallmark of spinal cord injury (SCI) and potassium channel blocker (PCB) is proven effective to restore axonal conduction and regain neurological function. Aiming to improve this therapy beyond the FDA-approved 4-AP, we have developed multiple new PCBs, with 4-AP-3-MeOH being the most potent and effective. The current study evaluated two PCBs, 4-AP-3-MeOH and 4-AP, in parallel in both ex vivo and in vivo rat mechanical SCI models. Specifically, 4-AP-3-MeOH induced significantly greater augmentation of axonal conduction than 4-AP in both acute and chronic injury...
December 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29145394/unc-16-jip3-regulates-early-events-in-synaptic-vesicle-protein-trafficking-via-lrk-1-lrrk2-and-ap-complexes
#14
Bikash Choudhary, Madhushree Kamak, Neena Ratnakaran, Jitendra Kumar, Anjali Awasthi, Chun Li, Ken Nguyen, Kunihiro Matsumoto, Naoki Hisamoto, Sandhya P Koushika
JIP3/UNC-16/dSYD is a MAPK-scaffolding protein with roles in protein trafficking. We show that it is present on the Golgi and is necessary for the polarized distribution of synaptic vesicle proteins (SVPs) and dendritic proteins in neurons. UNC-16 excludes Golgi enzymes from SVP transport carriers and facilitates inclusion of specific SVPs into the same transport carrier. The SVP trafficking roles of UNC-16 are mediated through LRK-1, whose localization to the Golgi is reduced in unc-16 animals. UNC-16, through LRK-1, also enables Golgi-localization of the μ-subunit of the AP-1 complex...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29123471/vglut2-trafficking-is-differentially-regulated-by-adaptor-proteins-ap-1-and-ap-3
#15
Haiyan Li, Magda S Santos, Chihyung K Park, Yuriy Dobry, Susan M Voglmaier
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that broadly distinguishes cortical (VGLUT1) and subcortical (VGLUT2) systems, and correlates with distinct physiological properties in synapses expressing these isoforms. Differential trafficking of VGLUT1 and 2 has been suggested to underlie their functional diversity...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29119181/ligand-directed-structural-diversity-and-magnetism-in-copper-ii-azido-assemblies-with-isomeric-aminopyridines-synthesis-structure-magnetism-and-theoretical-studies
#16
Priyanka Pandey, Bhagwan Kharediya, Bahjat Elrez, J-P Sutter, G Bhargavi, M V Rajasekharan, Sailaja S Sunkari
Four new copper complexes, viz. [{Cu(2-aminopyridine)(N3 )2 (H2 O)}2 ]n (1), [Cu3 (3-aminopyridine)2 (N3 )6 ]n (2), [{Cu(3-aminopyridine)(N3 )2 }2 ]n (3), and [Cu(4-aminopyridine)2 (N3 )2 ]n (4), have been synthesized with isomeric aminopyridines, viz. 2-aminopyridine (2-ap), 3-aminopyridine (3-ap), and 4-aminopyridine (4-ap), to probe the role of ligand and reactant molar ratios in directing the polynuclear assemblage and the associated magnetic properties. Ligand geometry is quite influential as can be seen through the versatile structures formed, viz...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29028839/interaction-of-the-human-respiratory-syncytial-virus-matrix-protein-with-cellular-adaptor-protein-complex-3-plays-a-critical-role-in-trafficking
#17
Casey Ward, Maciej Maselko, Christopher Lupfer, Meagan Prescott, Manoj K Pastey
Human Respiratory Syncytial Virus (HRSV) is a leading cause of bronchopneumonia in infants and the elderly. To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A). This novel protein-protein interaction was first detected via yeast-two hybrid screen and was further confirmed in a mammalian system by immunofluorescence colocalization and co-immunoprecipitation...
2017: PloS One
https://www.readbyqxmd.com/read/28975536/asthma-disease-as-cause-of-admission-to-hospitals-due-to-exposure-to-ambient-oxidants-in-mashhad-iran
#18
Hamid Reza Ghaffari, Hamideh Ebrahimi Aval, Ahmad Alahabadi, Adel Mokammel, Ramzanali Khamirchi, Samira Yousefzadeh, Ehsan Ahmadi, Abolfazl Rahmani-Sani, Mehdi Estaji, Amin Ghanbarnejad, Abdolmajid Gholizadeh, Mahmoud Taghavi, Mohammad Miri
Nowadays, asthma is one of the most common chronic respiratory diseases, worldwide. Many reports have emphasized the correlation between the short-term exposure to the ambient air pollutants and acute respiratory diseases, especially among children with asthmatic symptoms. The aim of this study was to evaluate the relationship between the exposure to three atmospheric antioxidants (NO2 , SO2 , and O3 ) and hospital admission due to asthmatic disease (HAAD) in the city of Mashhad, Iran. The concentrations of atmospheric antioxidants were obtained from the real-time monitoring stations located in the city...
December 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28881098/identification-and-engineering-of-post-pks-modification-bottlenecks-for-ansamitocin-p-3-titer-improvement-in-actinosynnema-pretiosum-subsp-pretiosum-atcc-31280
#19
Xinjuan Ning, Xinran Wang, Yuanting Wu, Qianjin Kang, Linquan Bai
The type-I polyketide ansamitocin P-3 (AP-3) is a potent antitumor agent. Its production is most likely hampered by the required multiple substrate supplies and complicated post-PKS modifications in Actinosynnema pretiosum subsp. pretiosum ATCC 31280. For titer improvement, gene ansa30, encoding for a glycosyltransferase competing for the N-demethyl-AP-3 (PND-3) intermediate for AP-3 biosynthesis, was initially inactivated. In the mutant NXJ-22, the AP-3 titer was increased by 66% along with an obvious accumulation of PND-3, indicating that the N-methylation is a rate-limiting step...
September 7, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28830473/survival-outcomes-of-hepatectomy-for-stage-b-hepatocellular-carcinoma-in-the-bclc-classification
#20
Toshiya Kamiyama, Tatsuya Orimo, Kenji Wakayama, Shingo Shimada, Akihisa Nagatsu, Hideki Yokoo, Hirofumi Kamachi, Kenichiro Yamashita, Tsuyoshi Shimamura, Akinobu Taketomi
BACKGROUND: Because hepatectomy is not recommended in patients with stage B hepatocellular carcinoma (HCC) of the Barcelona Clinic Liver Cancer (BCLC) staging, we evaluated the survival outcomes of hepatectomy for stage B in the BCLC system. METHODS: Data were collected from 297 consecutive adult stage B patients who underwent curative hepatectomy for HCC between 1996 and 2014 in Hokkaido University Hospital. Overall survival (OS), disease-free survival (DFS), and risk factors were analyzed using the Kaplan-Meier method...
August 22, 2017: World Journal of Surgical Oncology
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