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https://www.readbyqxmd.com/read/29689094/the-benefit-of-quality-control-charts-qcc-for-routine-quantitative-bcr-abl1-monitoring-in-chronic-myeloid-leukemia
#1
Birgit Spiess, Nicole Naumann, Norbert Galuschek, Sébastien Rinaldetti, Ute Kossak-Roth, Irina Tarnopolscaia, Elena Felde, Alice Fabarius, Wolf-Karsten Hofmann, Susanne Saußele, Wolfgang Seifarth
Quantitative real-time polymerase chain reaction (qRT-PCR) is state of the art in molecular monitoring of minimal residual disease in chronic myeloid leukemia (CML). In this context, maintenance of assay fidelity and detection of technical inaccuracy are crucial. Beside multiple common negative controls for the clinical sample preparations, quality control charts (QCC) are a common validation tool to sustain high process quality by continuously recording of qRT-PCR control parameters. Here, we report on establishment and benefit of QCC in qRT-PCR-based CML diagnostics...
2018: PloS One
https://www.readbyqxmd.com/read/29689054/community-health-worker-interventions-to-promote-psychosocial-outcomes-among-people-living-with-hiv-a-systematic-review
#2
Hae-Ra Han, Kyounghae Kim, Jeanne Murphy, Joycelyn Cudjoe, Patty Wilson, Phyllis Sharps, Jason E Farley
BACKGROUND: Community health worker (CHW) interventions are a successful strategy to promote health among HIV-negative and persons living with HIV (PLWH). Psychosocial factors are critical dimensions of HIV/AIDS care contributing to prognosis of the disease, yet it is unclear how CHW interventions improve psychosocial outcomes in PLWH. The purpose of this study was to critically appraise the types, scope, and nature of CHW interventions designed to address psychosocial outcomes in PLWH...
2018: PloS One
https://www.readbyqxmd.com/read/29684647/using-conversation-analytic-methods-to-assess-fidelity-to-a-talk-based-healthcare-intervention-for-frequently-attending-patients
#3
Rebecca K Barnes, Marcus Jepson, Clare Thomas, Sue Jackson, Chris Metcalfe, David Kessler, Helen Cramer
The study aim was to assess implementation fidelity (i.e., adherence) to a talk-based primary care intervention using Conversation Analytic (CA) methods. The context was a UK feasibility trial where General Practitioners (GPs) were trained to use "BATHE" (Background,Affect,Trouble,Handling,Empathy) - a technique to screen for psychosocial issues during consultations - with frequently attending patients. 35 GPs received BATHE training between July-October 2015. 15 GPs across six practices self-selected to record a sample of their consultations with study patients at three and six months...
April 11, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29677057/newborn-resuscitation-skills-in-health-care-providers-at-a-zambian-tertiary-center-and-comparison-to-world-health-organization-standards
#4
Sara C Mistry, Richard Lin, Hazel Mumphansha, Laura C Kettley, Janaki A Pearson, Sonia Akrimi, David J Mayne, Wonder Hangoma, M Dylan Bould
BACKGROUND: Birth asphyxia is a leading cause of early neonatal death. In 2013, 32% of neonatal deaths in Zambia were attributable to birth asphyxia and trauma. Basic, timely interventions are key to improving outcomes. However, data from the World Health Organization suggest that resuscitation is often not initiated, or is conducted suboptimally. Currently, there are little data on the quality of newborn resuscitation in the context of a tertiary center in a lower-middle income country...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#5
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29671644/short-play-and-communication-evaluation-teachers-assessment-of-core-social-communication-and-play-skills-with-young-children-with-autism
#6
Stephanie Y Shire, Wendy Shih, Ya-Chih Chang, Connie Kasari
Children with autism spectrum disorder experience delays in the development of nonverbal social communication gestures to request and to share (joint attention) as well as play skills such that intervention is required. Although such tools exist in research settings, community stakeholders also require access to brief, simple, and reliable tools to assess students' skills and set appropriate intervention targets. This study includes a sequence of two trials to examine implementation outcomes including adoption, fidelity, and feasibility of The Short Play and Communication Evaluation by educational professionals who work with preschoolers and toddlers with autism spectrum disorder in low-resource community classrooms...
April 2018: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29671253/novel-methods-for-screening-contributions-from-attachment-and-biobehavioral-catch-up
#7
E B Caron, Caroline K P Roben, Heather A Yarger, Mary Dozier
Preventative interventions are needed across the lifespan, including for children who have experienced maltreatment. However, interventions' effect sizes are typically smaller in real-world settings than in clinical trials. Identifying providers who are likely to implement interventions with fidelity could promote implementation outcomes through targeted allocation of training resources. This study tested two pre-training screening measures as predictors of provider fidelity to Attachment and Biobehavioral Catch-up (ABC), a preventative intervention for maltreated infants...
April 18, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29669066/does-health-informatics-have-a-replication-crisis
#8
Enrico Coiera, Elske Ammenwerth, Andrew Georgiou, Farah Magrabi
Objective: Many research fields, including psychology and basic medical sciences, struggle with poor reproducibility of reported studies. Biomedical and health informatics is unlikely to be immune to these challenges. This paper explores replication in informatics and the unique challenges the discipline faces. Methods: Narrative review of recent literature on research replication challenges. Results: While there is growing interest in re-analysis of existing data, experimental replication studies appear uncommon in informatics...
April 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29668726/the-effects-of-mothers-musical-background-on-sedentary-behavior-physical-activity-and-exercise-adherence-in-their-5-6-years-old-children-using-movement-to-music-video-program
#9
Pipsa P A Tuominen, Jani Raitanen, Pauliina Husu, Urho M Kujala, Riitta M Luoto
OBJECTIVES: The purpose of this study was to examine whether mothers' musical background has an effect on their own and their children's sedentary behavior (SB) and physical activity (PA). The aim was also to assess children's and their mothers' exercise adherence when using movement-to-music video program. DESIGN: Sub-group analysis of an intervention group in a randomized controlled trial (ISRCTN33885819). METHOD: Seventy-one mother-child-pairs were divided into two categories based on mothers' musical background...
2018: PloS One
https://www.readbyqxmd.com/read/29667497/how-do-contextual-factors-influence-implementation-and-receipt-of-positive-youth-development-programs-addressing-substance-use-and-violence-a-qualitative-meta-synthesis-of-process-evaluations
#10
Kelly Dickson, G J Melendez-Torres, Adam Fletcher, Kate Hinds, James Thomas, Claire Stansfield, Simon Murphy, Rona Campbell, Chris Bonell
OBJECTIVE: Positive youth development (PYD) often aims to prevent tobacco, alcohol, and drugs use and violence. We systematically reviewed PYD interventions, synthesizing process, and outcomes evidence. Synthesis of outcomes, published elsewhere, found no overall evidence of reducing substance use or violence but notable variability of fidelity. Our synthesis of process evaluations examined how implementation varied and was influenced by context. DATA SOURCE: Process evaluations of PYD aiming to reduce substance use and violence...
May 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29665889/using-implementation-intentions-to-prevent-relapse-after-psychological-treatment-for-depression-the-smart-intervention
#11
Mike Lucock, Serena Bartys, Jade Cupac, Jaime Delgadillo, Charlotte Denton, Sarah Gaines, Dean McMillan, Andrew Prestwich, Rick Stebbings
BACKGROUND: It is recognized that a significant proportion of people with depression are prone to relapse, even after successful treatment, and that self-management interventions should be developed and provided. There is evidence that implementation intentions (IMPS) can be successfully applied to health-related behaviours but their application to self-management of mental health problems has been limited. AIMS: This paper describes the design and initial evaluation of a Self-Management After Therapy (SMArT) intervention, which incorporated IMPS and followed psychological therapy for depression...
April 18, 2018: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29665478/developing-an-obesity-intervention-in-micronesia-from-needs-assessment-to-planning
#12
Ann Futterman Collier, Suzanne Daiss, Everlynn Temengil, Samantha Cody Russell, Julia Caroline Miller, Fumiana M Renguul
Evidence-based obesity reduction programs in the Pacific are scarce to nonexistent. Using a community-based participatory research model (CBPR) we developed a collaboration between our university and a small Pacific Island nation. We established an advisory council of local stakeholders and then conducted an extensive needs assessment with youth, parents, professionals, and lay public. Only 9% of participants had tried a weight loss program. There was a strong tendency to engage in binge-eating cycles; difficulty eating healthy during frequent community celebrations with few healthy food options available in general; and limited traditions that involved physical activity...
April 5, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29651872/the-effectiveness-of-12-weeks-of-pilates-intervention-on-disability-pain-and-kinesiophobia-in-patients-with-chronic-low-back-pain-a-randomized-controlled-trial
#13
David Cruz-Díaz, Marta Romeu, Carmen Velasco-González, Antonio Martínez-Amat, Fidel Hita-Contreras
OBJECTIVE: To assess the effectiveness of 12 weeks of Pilates practice on disability, pain and kinesiophobia in patients with chronic non-specific low back pain. DESIGN: This is a randomized controlled trial. SETTING: This study was conducted in the university laboratory. SUBJECTS: A total of 64 participants with chronic non-specific low back pain were included. INTERVENTIONS: Participants were randomly allocated to intervention group consisted in Pilates intervention during 12 weeks ( n = 32) or control group who received no treatment ( n = 32)...
April 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29649373/iot-for-real-time-measurement-of-high-throughput-liquid-dispensing-in-laboratory-environments
#14
Justin Shumate, Pierre Baillargeon, Timothy P Spicer, Louis Scampavia
Critical to maintaining quality control in high-throughput screening is the need for constant monitoring of liquid-dispensing fidelity. Traditional methods involve operator intervention with gravimetric analysis to monitor the gross accuracy of full plate dispenses, visual verification of contents, or dedicated weigh stations on screening platforms that introduce potential bottlenecks and increase the plate-processing cycle time. We present a unique solution using open-source hardware, software, and 3D printing to automate dispenser accuracy determination by providing real-time dispense weight measurements via a network-connected precision balance...
April 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29644545/adaptive-recruitment-and-parenting-interventions-for-immigrant-latino-families-with-adolescents
#15
Diego Garcia-Huidobro, Maria O Diaspro-Higuera, Dora Palma, Roberto Palma, Luis Ortega, Rebecca Shlafer, Elizabeth Wieling, Timothy Piehler, Gerald August, Maria V Svetaz, Iris W Borowsky, Michele L Allen
Parenting programs are an effective strategy to prevent multiple risky outcomes during adolescence. However, these programs usually enroll one caregiver and have low attendance. This study evaluated the preliminary results, cost, and satisfaction of adaptive recruitment and parenting interventions for immigrant Latino families. A mixed methods study was conducted integrating a pre-post design with embedded qualitative and process evaluations. Fifteen immigrant Latino families with an adolescent child aged 10-14 were recruited...
April 11, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29642868/adaptation-of-an-evidence-based-postpartum-depression-intervention-feasibility-and-acceptability-of-mothers-and-babies-1-on-1
#16
S Darius Tandon, Julie A Leis, Erin A Ward, Hannah Snyder, Tamar Mendelson, Deborah F Perry, Mya Carter, Jaime Hamil, Huynh-Nhu Le
BACKGROUND: Mothers and Babies (MB) is a cognitive-behavioral intervention with demonstrated efficacy in reducing depressive symptoms and preventing depressive episodes among perinatal women when delivered in a group format by mental health professionals. Study aims were to describe the adaptation of MB into a 1-on-1 modality (MB 1-on-1) and provide data on the adapted intervention's acceptability and feasibility. METHODS: Seventy-five home visitors trained on MB 1-on-1 delivered the 15-session intervention to 1-2 clients...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29642707/an-integrated-motivational-interviewing-and-cognitive-behavioural-intervention-promoting-physical-activity-maintenance-for-adults-with-chronic-health-conditions-a-feasibility-study
#17
Sarah E Scott, Jeff D Breckon, Robert J Copeland
Objectives Physical activity is recommended for managing chronic health conditions but is rarely maintained. This feasibility study aimed to evaluate the preliminary efficacy of a motivational interviewing and cognitive-behavioural intervention for long-term physical activity for adults with chronic health conditions. Methods Participants ( N = 37) with stable conditions (e.g. diabetes) were randomized into a three-month motivational interviewing and cognitive-behavioural group ( N = 20) or usual care ( N = 17) after completing a physical activity referral scheme...
January 1, 2018: Chronic Illness
https://www.readbyqxmd.com/read/29628333/multidisciplinary-difficult-airway-course-an-essential-educational-component-of-a-hospital-wide-difficult-airway-response-program
#18
W Robert Leeper, Elliott R Haut, Vinciya Pandian, Sajan Nakka, Jeffrey Dodd-O, Nasir Bhatti, Elizabeth A Hunt, Mustapha Saheed, Nicholas Dalesio, Adam Schiavi, Christina Miller, Thomas D Kirsch, Lauren Berkow
OBJECTIVE: A hospital-wide difficult airway response team was developed in 2008 at The Johns Hopkins Hospital with three central pillars: operations, safety monitoring, and education. The objective of this study was to assess the outcomes of the educational pillar of the difficult airway response team program, known as the multidisciplinary difficult airway course (MDAC). DESIGN: The comprehensive, full-day MDAC involves trainees and staff from all provider groups who participate in airway management...
April 5, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29628066/abnormal-functional-connectivity-of-frontopolar-subregions-in-treatment-nonresponsive-major-depressive-disorder
#19
Peter W Fettes, Massieh Moayedi, Katharine Dunlop, Farrokh Mansouri, Fidel Vila-Rodriguez, Peter Giacobbe, Karen D Davis, Raymond W Lam, Sidney H Kennedy, Zafiris J Daskalakis, Daniel M Blumberger, Jonathan Downar
BACKGROUND: Approximately 30% of patients with major depressive disorder develop treatment-nonresponsive depression (TNRD); novel interventions targeting the substrates of this illness population are desperately needed. Convergent evidence from lesion, stimulation, connectivity, and functional neuroimaging studies implicates the frontopolar cortex (FPC) as a particularly important region in TNRD pathophysiology; regions functionally connected to the FPC, once identified, could present favorable targets for novel brain stimulation treatments...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29627695/mindfulness-based-resilience-training-to-reduce-health-risk-stress-reactivity-and-aggression-among-law-enforcement-officers-a-feasibility-and-preliminary-efficacy-trial
#20
Michael S Christopher, Matthew Hunsinger, Lt Richard J Goerling, Sarah Bowen, Brant S Rogers, Cynthia R Gross, Eli Dapolonia, Jens C Pruessner
The primary objective of this study was to assess feasibility and gather preliminary outcome data on Mindfulness-Based Resilience Training (MBRT) for law enforcement officers. Participants (n = 61) were randomized to either an 8-week MBRT course or a no intervention control group. Self-report and physiological data were collected at baseline, post-training, and three months following intervention completion. Attendance, adherence, post-training participant feedback, and interventionist fidelity to protocol all demonstrated feasibility of MBRT for law enforcement officers...
March 23, 2018: Psychiatry Research
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