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Carotid Atherosclerotic unstable plaque

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https://www.readbyqxmd.com/read/28706117/age-specific-sex-differences-in-magnetic-resonance-imaging-depicted-carotid-intraplaque-hemorrhage
#1
Navneet Singh, Alan R Moody, Bowen Zhang, Isabella Kaminski, Kush Kapur, Stephanie Chiu, Pascal N Tyrrell
BACKGROUND AND PURPOSE: Stroke rates are higher in men compared with women in the fourth through seventh decades of life, and higher rates may result from differences in carotid intraplaque hemorrhage (IPH), an unstable atherosclerotic plaque component. We report age-specific sex differences in the presence of magnetic resonance imaging-depicted carotid IPH. METHODS: Patients (n=1115) underwent magnetic resonance imaging for carotid IPH between 2005 and 2014. Low-grade carotid stenosis patients (n=906) without prior endarterectomy were eligible for this cross-sectional study...
July 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28615715/rnaseq-based-transcriptomics-study-of-smcs-from-carotid-atherosclerotic-plaque-bmp2-and-ids-proteins-are-crucial-regulators-of-plaque-stability
#2
Iraide Alloza, Haize Goikuria, Juan Luis Idro, Juan Carlos Triviño, José María Fernández Velasco, Elena Elizagaray, María García-Barcina, Genoveva Montoya-Murillo, Esther Sarasola, Reyes Vega Manrique, Maria Del Mar Freijo, Koen Vandenbroeck
Carotid artery atherosclerosis is a risk factor to develop cerebrovascular disease. Atheroma plaque can become instable and provoke a cerebrovascular event or else remain stable as asymptomatic type. The exact mechanism involved in plaque destabilization is not known but includes among other events smooth muscle cell (SMC) differentiation. The goal of this study was to perform thorough analysis of gene expression differences in SMCs isolated from carotid symptomatic versus asymptomatic plaques. Comparative transcriptomics analysis of SMCs based on RNAseq technology identified 67 significant differentially expressed genes and 143 significant differentially expressed isoforms in symptomatic SMCs compared with asymptomatic...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28575478/the-preservation-of-cognition-1-yr-after-carotid-endarterectomy-in-patients-with-prior-cognitive-decline
#3
Robert J Dempsey, Daren C Jackson, Stephanie M Wilbrand, Carol C Mitchell, Sara E Berman, Sterling C Johnson, Nirvedh H Meshram, Tomy Varghese, Bruce P Hermann
BACKGROUND: Vascular cognitive decline is critically important in the course of atherosclerosis and stroke. OBJECTIVE: To explore the hypothesis that carotid endarterectomy (CEA) by removing an unstable plaque may slow the course of vascular cognitive decline in both symptomatic and asymptomatic patients. METHODS: Patients with clinically significant (>60%) carotid stenosis were studied preop and 1 yr post-CEA for clinical symptoms, vascular cognitive decline, instability of carotid plaque-presence of microemboli, brain white matter changes, and medical risk factors...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28559142/ag1296-enhances-plaque-stability-via-inhibiting-inflammatory-responses-and-decreasing-mmp-2-and-mmp-9-expression-in-apoe-mice
#4
Min Dong, Changping Zhou, Liang Ji, Bing Pan, Lemin Zheng
BACKGROUND: Atherosclerosis is a chronic process that progresses to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, thrombosis and stroke. AG1296 is a potent tyrosine kinase inhibitor which is able to block PDGF-PDGFR signaling pathway. This study aims to assess the effect of AG1296 on plaque stability and explore the potential mechanisms. METHODS: Atherosclerotic plaques were induced in carotid arteries in ApoE-/- mice by perivascular collar placement...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28513228/relationship-between-chop-gadd153-and-unstable-human-carotid-atherosclerotic-plaque
#5
Suping Wang, Meiyan Zhang, Zanhua Liu, Wuyang Yang, Junwei Shi, Victor Dean, Dong Chen
BACKGROUND AND AIMS: The signaling protein C/EBP homologous protein (CHOP) and corresponding growth-arrest-and-DNA-damage-inducible gene 153 (GADD153) is associated with endoplasmic reticulum stress (ERS), which can lead to apoptosis. Our study aims to elucidate the role of CHOP/GADD153 in unstable atherosclerotic (AS) plaque formation isolated from confounding factors such as diabetes mellitus, primary hyperlipidemia, autoimmune deficiencies/abnormalities, essential hypertension, chronic heart failure, chronic kidney disease, and smoking...
May 17, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28436693/expression-of-circulating-mir-17-92-cluster-and-hdac9-gene-in-atherosclerotic-patients-with-unstable-and-stable-carotid-plaques
#6
Silvia Ferronato, Aldo Mombello, Ilaria Posenato, Paola Candiani, Alberto Scuro, Carlo Setacci, Macarena Gomez-Lira
AIMS: The miR-17-92 cluster and the HDAC9 gene are involved in inflammatory, apoptotic, and angiogenic processes that are activated in the vulnerable carotid plaque. The aim of this research was to determine whether expression of one or more of the miRs of the miR-17-92 cluster and/or HDAC9 expression could represent biomarkers for patients with unstable atherosclerotic carotid plaques. MATERIALS AND METHODS: Plasma levels of miRs and HDAC9 expression in peripheral blood were analyzed by real-time PCR in patients with histologically classified stable or unstable plaques...
June 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28427600/carotid-artery-stenting-investigation-of-plaque-protrusion-incidence-and-prognosis
#7
Masashi Kotsugi, Katsutoshi Takayama, Kaoru Myouchin, Takeshi Wada, Ichiro Nakagawa, Hiroyuki Nakagawa, Toshiaki Taoka, Shinichiro Kurokawa, Hiroyuki Nakase, Kimihiko Kichikawa
OBJECTIVES: This study sought to clarify the incidence and prognosis of PP in carotid artery stenting (CAS). BACKGROUND: Projections thought to be plaque may be observed inside the stent on angiography or intravascular ultrasound (IVUS) during CAS. Known as plaque protrusion (PP), the incidence and prognosis of this complication are unclear. METHODS: A total of 354 consecutive carotid atherosclerotic stenoses in 328 patients (285 men, 43 women; age range 51 to 97 years [mean age 73...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28349887/atherosclerotic-plaque-metabolism-in-high-cardiovascular-risk-subjects-a-subclinical-atherosclerosis-imaging-study-with-18-f-naf-pet-ct
#8
Manuel de Oliveira-Santos, Miguel Castelo-Branco, Rodolfo Silva, Andreia Gomes, Nuno Chichorro, Antero Abrunhosa, Paulo Donato, João Pedroso de Lima, Mariano Pego, Lino Gonçalves, Maria João Ferreira
BACKGROUND AND AIMS: Atherosclerotic plaque molecular imaging with (18)F-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study (18)F-NaF atherosclerotic plaque uptake in high cardiovascular (CV) risk participants and its associations with CV risk factors, coronary calcium score and thoracic fat volume. METHODS: High CV risk hypertensive individuals from a single centre were prospectively scanned with (18)F-NaF-PET-CT in the coronary, aortic and carotideal arteries...
May 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28285652/circulating-adiponectin-levels-in-relation-to-carotid-atherosclerotic-plaque-presence-ischemic-stroke-risk-and-mortality-a-systematic-review-and-meta-analyses
#9
REVIEW
Jessica Gorgui, Karina Gasbarrino, Marios K Georgakis, Maria A Karalexi, Bénédicte Nauche, Eleni Th Petridou, Stella S Daskalopoulou
BACKGROUND: Low circulating levels of adiponectin, an anti-inflammatory and vasculoprotective adipokine, are associated with obesity, type 2 diabetes, and atherosclerotic disease. Presence of unstable plaques in the carotid artery is a known etiological factor causing ischemic strokes. Herein, we systematically reviewed the association between circulating adiponectin and progression of carotid atherosclerotic disease, particularly evaluating the occurrence of (1) carotid atherosclerotic plaques, (2) ischemic stroke, and (3) mortality in subjects who suffered a previous ischemic stroke...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28258256/decreased-adiponectin-mediated-signaling-through-the-adipor2-pathway-is-associated-with-carotid-plaque-instability
#10
Karina Gasbarrino, Huaien Zheng, Anouar Hafiane, John P Veinot, Chi Lai, Stella S Daskalopoulou
BACKGROUND AND PURPOSE: Adiponectin, the most abundantly secreted anti-inflammatory adipokine, protects against all stages of atherosclerotic plaque formation by acting on its receptors, AdipoR1 (adiponectin receptor 1) and AdipoR2 (adiponectin receptor 2). Through binding of AdipoR1, adiponectin leads to the activation of the AMPK (adenosine monophosphate-activated protein kinase) pathway, whereas stimulation of PPAR-α (peroxisome proliferator-activated receptor-α) is attributed to the binding of AdipoR2...
April 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28214453/reciprocal-regulation-of-enos-h2s-and-co-synthesizing-enzymes-in-human-atheroma-correlation-with-plaque-stability-and-effects-of-simvastatin
#11
Fragiska Sigala, Panagiotis Efentakis, Dimitra Karageorgiadi, Konstadinos Filis, Paraskevas Zampas, Efstathios K Iliodromitis, George Zografos, Andreas Papapetropoulos, Ioanna Andreadou
The molecular and cellular mechanisms underlying plaque destabilization remain obscure. We sought to elucidate the correlation between NO, H2S and CO-generating enzymes, nitro-oxidative stress and plaque stability in carotid arteries. Carotid atherosclerotic plaques were collected from 62 patients who had undergone endarterectomy due to internal artery stenosis. Following histological evaluation the plaques were divided into stable and unstable ones. To investigate the impact of simvastatin we divided patients with stable plaques, into those receiving and to those not receiving simvastatin...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28011257/cellular-subtype-expression-and-activation-of-camkii-regulate-the-fate-of-atherosclerotic-plaque
#12
Angela Serena Maione, Ersilia Cipolletta, Daniela Sorriento, Francesco Borriello, Maria Soprano, Maria Rosaria Rusciano, Vittoria D'Esposito, Abdul Karim Markabaoui, Giovanni Domenico De Palma, Giovanni Martino, Lucio Maresca, Giuseppe Nobile, Pietro Campiglia, Pietro Formisano, Michele Ciccarelli, Gianni Marone, Bruno Trimarco, Guido Iaccarino, Maddalena Illario
BACKGROUND AND AIMS: Atherosclerosis is a degenerative process of the arterial wall implicating activation of macrophages and proliferation of vascular smooth muscle cells. Calcium-calmodulin dependent kinase type II (CaMKII) in vascular smooth muscle cells (VSMCs) regulates proliferation, while in macrophages, this kinase governs diapedesis, infiltration and release of extracellular matrix enzymes. We aimed at understanding the possible role of CaMKII in atherosclerosis plaques to regulate plaque evolution towards stability or instability...
January 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28009484/hsp90-inhibition-suppresses-inflammatory-response-and-reduces-carotid-atherosclerotic-plaque-formation-in-apoe-mice
#13
Hongmei Mu, Liyong Wang, Lei Zhao
AIM: Emerging evidences indicate that heat-shock protein 90 (HSP90) is associated with atherogenesis. However, the effect of HSP90 on plaque stability is largely unknown. In this study, we explored the role of HSP90 in plaque development and its regulatory mechanisms on vasculature. METHODS: Heat-shock protein90-overexpression lentivirus (Lenti-HSP90) was used to transfect apoE(-/-) mice after constrictive collars were planted at the right common carotid arteries...
April 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27940038/increased-levels-of-legumain-in-plasma-and-plaques-from-patients-with-carotid-atherosclerosis
#14
Ngoc Nguyen Lunde, Sverre Holm, Tuva B Dahl, Inass Elyouncha, Bjørnar Sporsheim, Ida Gregersen, Azhar Abbas, Mona Skjelland, Terje Espevik, Rigmor Solberg, Harald Thidemann Johansen, Bente Halvorsen
BACKGROUND AND AIMS: The cysteine protease legumain has been shown to be up-regulated in unstable atherosclerotic plaques. This study aims to further elucidate legumain in atherosclerosis, by examining legumain in plasma and carotid plaques from patients with carotid stenosis. Furthermore, legumain secretion from monocyte-derived macrophages treated with atherogenic lipids during macrophage polarization was studied. METHODS: Plasma levels of legumain from patients with carotid stenosis (n = 254), healthy controls (n = 91), and secreted from monocyte-derived macrophages were assessed by enzyme-linked-immunosorbent assay...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/27895035/microrna-210-enhances-fibrous-cap-stability-in-advanced-atherosclerotic-lesions
#15
Suzanne M Eken, Hong Jin, Ekaterina Chernogubova, Yuhuang Li, Nancy Simon, Changyan Sun, Greg Korzunowicz, Albert Busch, Alexandra Bäcklund, Cecilia Österholm, Anton Razuvaev, Thomas Renné, Hans Henning Eckstein, Jaroslav Pelisek, Per Eriksson, María González Díez, Ljubica Perisic Matic, Isabel N Schellinger, Uwe Raaz, Nicholas J Leeper, Göran K Hansson, Gabrielle Paulsson-Berne, Ulf Hedin, Lars Maegdefessel
RATIONALE: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. OBJECTIVE: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. METHODS AND RESULTS: Using patient material from the BiKE (Biobank of Karolinska Endarterectomies), we profiled miRNA expression in patients with stable versus unstable carotid plaque. A polymerase chain reaction-based miRNA array of plasma, sampled at the carotid lesion site, identified 8 deregulated miRNAs (miR-15b, miR-29c, miR-30c/d, miR-150, miR-191, miR-210, and miR-500)...
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/27845316/-active-thermolocation-probing-as-a-promising-rapid-diagnostic-test-of-carotid-atherosclerosis
#16
I D Stulin, O O Yanushevich, S A Trukhanov, D S Solonsky, O N Budadin, E F Ivanushkin, A G Sazonova
AIM: To study the possibility of active thermolocation probing for the diagnosis of stenotic lesions of carotid arteries (CA). MATERIAL AND METHODS: Eighteenpatients without symptoms of cardiovascular diseases were examined using ultrasound. The patients had isoechogenic stable atherosclerotic plaques (AP). Ultrasound markers of AP instability were found in other patients. All patients underwent telethermography of face, neck and extremities, ultrasound duplex scanning of CA...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27816808/talin-and-vinculin-are-downregulated-in-atherosclerotic-plaque-tampere-vascular-study
#17
Magdaléna von Essen, Rolle Rahikainen, Niku Oksala, Emma Raitoharju, Ilkka Seppälä, Ari Mennander, Thanos Sioris, Ivana Kholová, Norman Klopp, Thomas Illig, Pekka J Karhunen, Mika Kähönen, Terho Lehtimäki, Vesa P Hytönen
BACKGROUND AND AIMS: Focal adhesions (FA) play an important role in the tissue remodeling and in the maintenance of tissue integrity and homeostasis. Talin and vinculin proteins are among the major constituents of FAs contributing to cellular well-being and intercellular communication. METHODS: Microarray analysis (MA) and qRT-PCR low-density array were implemented to analyze talin-1, talin-2, meta-vinculin and vinculin gene expression in circulating blood and arterial plaque...
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27714714/evaluation-of-mean-platelet-volume-and-platelet-distribution-width-in-patients-with-asymptomatic-intermediate-carotid-artery-plaque
#18
Fatih Yılmaz, Erkan Köklü, Filiz Kizilirmak Yilmaz, Elif Sarıönder Gencer, Ahmet Şükrü Alparslan, Özlem Yıldırımtürk
BACKGROUND: Platelets play a significant role in the pathogenesis of atherosclerosis. In atherosclerotic plaques, the risk of plaque rupture is more crucial than the severity of the stenosis they cause. Non-calcified carotid artery plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism, and consequently, stroke. AIM: The purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis, with respect to mean platelet volume (MPV) and platelet distribution width (PDW)...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/27682808/incidence-and-predictors-of-cardiovascular-events-in-a-cohort-of-patients-with-rheumatoid-arthritis
#19
A M Castro, D Carmona-Fernandes, A M Rodrigues, L M Pedro, M J Santos, H Canhão, J E Fonseca
INTRODUCTION: An excess in cardiovascular (CV) morbidity and mortality has been recognized in Rheumatoid Arthritis (RA) patients when compared to the general population. Given the paucity of prospective data, our aim was to estimate the incidence of CV events and the contribution of traditional CVD risk factors and RA-related parameters to future events. METHODS: Incident fatal and non-fatal CV events (hospitalizations due to unstable angina, myocardial infarction, coronary artery revascularization procedures, stroke, or CV death) were assessed in a prospective cohort of RA women followed since 2007 and without CV events at cohort entry...
July 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27648042/analysis-of-carotid-color-ultrasonography-and-high-sensitive-c-reactive-protein-in-patients-with-atherosclerotic-cerebral-infarction
#20
Lei Zhao, Zhanyi Zhai, Wei Hou
OBJECTIVES: To detect the correlation between high-sensitivity-CRP, carotid plaque, neurological function and intima-media thickness, and help physicians in the diagnosis of atherosclerotic cerebral infarction. METHODS: A total of 96 patients with the first onset of atherosclerotic cerebral infarction were included in the study from July 2013 to May 2015. The test of high-sensitivity-CRP, examination of carotid color ultrasonography and neurological function evaluation were carried out for all the participants...
July 2016: Pakistan Journal of Medical Sciences Quarterly
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