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Vitamin B12 deficiency

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https://www.readbyqxmd.com/read/29675077/a-tale-of-treatable-infantile-neuroregression-and-diagnostic-dilemma-with-glutaric-aciduria-type-i
#1
Sangeetha Yoganathan, Mugil Varman, Samuel Philip Oommen, Maya Thomas
Nutritional deficiencies related neurological manifestations are not uncommon in infants and children. Here, we describe an infant with Vitamin B12 deficiency due to depleted maternal Vitamin B12 status presenting with progressive encephalopathy and extrapyramidal signs. Diagnosis of infantile tremor syndrome was established in our patient based on the clinical and biochemical parameters. Magnetic resonance imaging had shown frontotemporal atrophy with widened Sylvian fissures and prominent cerebrospinal fluid spaces...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29672394/effects-of-vitamin-b-complex-and-vitamin-c-on-human-skin-cells-is-the-perceived-effect-measurable
#2
Julian-Dario Rembe, Carolin Fromm-Dornieden, Ewa Klara Stuermer
OBJECTIVE: Vitamins are essential for human health. In terms of local application for wound healing, vitamins' positive effect remains unclear. However, because of the regular appearance of nutritional deficiency in chronic wound patients, a favorable impact of locally applied vitamins can be hypothesized. METHODS: Vitamins B3, B5, B6, B7, B9, B10, B12, and C individually as well as different combinations of B vitamins were investigated regarding their ability to promote proliferation and migration of human skin fibroblasts and keratinocytes...
May 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29669023/the-relevance-of-vitamin-and-iron-deficiency-in-patients-with-inflammatory-bowel-diseases-in-patients-of-the-swiss-ibd-cohort
#3
Matiar Madanchi, Stefania Fagagnini, Nicolas Fournier, Luc Biedermann, Jonas Zeitz, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl
Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC)...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29663261/evaluation-of-diffusion-tensor-imaging-changes-and-neurocognitive-effects-of-asymptomatic-vitamin-b12-deficiency
#4
Ali Zeynal Abidin Tak, Erdal Dayan, Hacı Taner Bulut
Vitamin B12 plays an important role in the mechanisms which are responsible for myelinization in the central nervous system. It can particularly lead to hematological and neuropsychiatric symptoms when serum levels fall due to insufficient intake with diet or absorption problems. The purpose of this study was to show the cognitive effects in vitamin B12 deficiency cases that have not reached clinical symptom level using neuropsychological tests, and to show possible cerebral neuronal damage using diffusion tensor imaging (DTI) method...
April 16, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29661593/-diagnostic-workup-in-front-of-an-atypical-non-hemolytic-anemia
#5
J Y Colin, G Vignon, P Mottaz, J Labrousse, F Carrere, P F Augereau, P Aucher, F Lellouche
The most potential causes of "non hemolytic" anemias are iron, folate or vitamin B12 deficiencies, severe renal impairment, endocrine diseases, inflammation and medullary disorders. In a non-exceptionnal way no cause is found, sometimes because of a wrong interpretation of analysis results and sometimes because of a little known etiology. The goal of this review is to point out analytical difficulties and to remember some rarer etiologies.
April 13, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29661265/invited-commentary-in-response-to-identification-of-vitamin-b12-deficiency-in-vegetarian-indians
#6
Luciana Hannibal
No abstract text is available yet for this article.
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29650139/follow-up-management-of-cystectomy-patients
#7
REVIEW
Madhumitha Reddy, Karim Kader
Bladder cancer is the sixth leading cancer in the United States. Radical cystectomy is a lifesaving procedure for bladder cancer with or without muscle invasion. Radical cystectomy is performed on 39% of these patients, and 35% will have a life-threatening recurrence. Distant metastases are the most common; local, upper tract, and urethral recurrence can also occur. Surveillance after cystectomy is critical to diagnosing recurrence early. Functional complications after urinary diversion include bowel dysfunction, vitamin B12 deficiency, acidosis, electrolyte abnormalities, osteopenia, nephrolithiasis, urinary tract infections, renal functional decline, and urinary obstruction, which can be reversed when diagnosed early...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29643928/effect-of-low-energy-diet-for-eight-weeks-to-adults-with-overweight-or-obesity-on-folate-retinol-vitamin-b-12-d-and-e-status-and-the-degree-of-inflammation-a-post-hoc-analysis-of-a-randomized-intervention-trial
#8
Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29613894/metabolic-and-toxic-myelopathies
#9
Robert N Schwendimann
PURPOSE OF REVIEW: Myelopathy may occur as a consequence of various metabolic and toxic conditions. This article provides an update on the clinical presentations, diagnostic evaluations, and management of metabolic and toxic myelopathies. RECENT FINDINGS: Myelopathy and myeloneuropathy due to vitamin B12 deficiency is increasing in prevalence partly because of an aging population. Early recognition of the clinical symptoms and rapid initiation of treatment is essential...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29611017/prevalence-of-nutritional-deficiencies-among-populations-of-newly-arriving-government-assisted-refugee-children-to-kitchener-waterloo-ontario-canada
#10
Carolyn Beukeboom, Neil Arya
This study examined the variation among ethnic populations in prevalence of anemia, vitamin D and B12 deficiencies among refugee children. A retrospective chart review of 388 government assisted refugee children ≤ 16 years of age, seen at the Refugee Health Clinic in Kitchener, Canada from January 2009 to December 2014 was conducted. Vitamin D levels were only collected until December 1st 2010 (116 children). 15.7% were anemic (25% < 5 years, 8.7% 5-11 years, and 18.3% 12-16 years old) with Somali children having the lowest hemoglobin levels compared to those from Iraq, Afghanistan and Myanmar...
April 2, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29610943/restless-legs-syndrome-is-a-relevant-comorbidity-in-patients-with-inflammatory-bowel-disease
#11
Janek Becker, Felix Berger, Katharina A Schindlbeck, Denis Poddubnyy, Peter M Koch, Jan C Preiß, Britta Siegmund, Frank Marzinzik, Jochen Maul
BACKGROUND AND AIMS: In patients with inflammatory bowel disease (IBD), restless legs syndrome (RLS) may occur as an extraintestinal disease manifestation. Iron deficiency (ID) or folate deficiency/vitamin B12 deficiency (FD/VB12 D) has previously been described to cause RLS. Here, we determined the prevalence and severity of RLS in IBD patients and evaluated the effect of iron and/or folic acid/vitamin B12 supplementation. METHODS: Patients were screened for ID and RLS by a gastroenterologist...
April 3, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29610598/proton-pump-inhibitors-intake-and-iron-and-vitamin-b12-status-a-prospective-comparative-study-with-a-follow-up-of-12-months
#12
Hasime Qorraj-Bytyqi, Rexhep Hoxha, Shemsedin Sadiku, Ismet H Bajraktari, Mentor Sopjani, Kujtim Thaçi, Shpetim Thaçi, Elton Bahtiri
BACKGROUND: Proton pump inhibitors (PPIs) represent the most widely prescribed antisecretory agents, but their prolonged use, may influence iron and vitamin B12 status, which could have important implications for clinical practice. AIM: We undertook this study aiming to investigate the association between PPIs use for 12 months and potential changes in iron and vitamin B12 status, as well as whether this potential association varies among four specific PPI drugs used in the study...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29599609/correlation-between-serum-vitamin-b12-level-and-peripheral-neuropathy-in-atrophic-gastritis
#13
Guo-Tao Yang, Hong-Ying Zhao, Yu Kong, Ning-Ning Sun, Ai-Qin Dong
AIM: To explore the correlation between serum vitamin B12 level and peripheral neuropathy in patients with chronic atrophic gastritis (CAG). METHODS: A total of 593 patients diagnosed with chronic gastritis by gastroscopy and pathological examination from September 2013 to September 2016 were selected for this study. The age of these patients ranged within 18- to 75-years-old. Blood pressure, height and weight were measured in each patient, and the body mass index value was calculated...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29597190/vitamin-b12-deficiency-and-the-role-of-gender-a-cross-sectional-study-of-a-large-cohort
#14
Ili Margalit, Eytan Cohen, Elad Goldberg, Ilan Krause
BACKGROUND: Vitamin B12 deficiency is associated with hematological, neurological, and cardiovascular consequences. Epidemiologic data on these related illnesses indicate gender differences. METHODS: A cross-sectional study was designed to examine gender differences in vitamin B12 deficiency among a healthy population. Data from healthy individuals aged 18-65, who were provided with a routine medical evaluation during 2000-2014, were retrieved from the medical charts...
March 29, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29579413/the-unusual-nutritional-and-toxin-related-underproduction-anemias-approaching-the-riddle-beyond-iron-cobalamin-and-folate
#15
Cristhiam Mauricio Rojas-Hernandez, Thein Hlaing Oo
"Anemias beyond iron, vitamin B12, and folate deficiencies" covers a wide array of everything which lies beyond commonly seen anemias caused by deficiencies of three micronutrients. Although anemias due to deficiencies of iron, B12, and folate are common in daily practice and account for at least one-third of anemia etiologies in older adults, it is not uncommon to encounter other nutritional and toxin-induced underproduction anemias. The combination of thorough clinical examination, careful peripheral blood smear review, and judicious selection of supporting laboratory studies is typically sufficient to make an assertive diagnosis of those cases...
February 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29577819/comparison-of-the-efficacy-of-parenteral-and-oral-treatment-for-nutritional-vitamin-b12-deficiency-in-children
#16
Rabia Gönül Sezer, Handan Ayhan Akoğlu, Abdulkadir Bozaykut, Gül Nihal Özdemir
OBJECTIVE: Although, oral replacement for vitamin B12 deficiency has been proved to be effective in adults, it is mainly treated with parenteral therapy. There are only few studies on oral replacement therapy of vitamin B12 with children. Therefore, we aimed to compare the efficacy of oral treatment with intramuscular vitamin B12 injections in pediatric population. METHODS: Children with serum cobalamin concentrations less than 300 pg/mL, were treated either with the parenteral therapy or with oral vitamin B12...
March 24, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29572125/hemoglobin-iron-vitamin-b12-and-folic-acid-deficiencies-and-hyperhomocysteinemia-in-behcet-s-disease-patients-with-atrophic-glossitis
#17
Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed whether 30 AG-positive RAS/BD (AG+ RAS/BD) patients had significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia than 33 AG-negative RAS/BD (AG־RAS/BD) patients or 126 age- and sex-matched healthy control subjects. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations were measured and compared among 30 AG+ RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects...
March 20, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29571016/the-role-of-nutrients-in-the-pathogenesis-and-treatment-of-migraine-headaches-review
#18
REVIEW
Elyas Nattagh-Eshtivani, Mahmood Alizadeh Sani, Monireh Dahri, Faezeh Ghalichi, Abed Ghavami, Pishva Arjang, Ali Tarighat-Esfanjani
OBJECTIVE: Migraine as a disabling neurovascular disease affects 6% of men and 18% of women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, α-lipoic acid and vitamin D is associated with migraine. Some researchers postulate that mitochondrial dysfunction and impaired antioxidant status can cause migraine. Also increase in homocysteine level can lead to migraine attacks; therefore, some Nutraceuticals play a vital role in migraine prevention...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29562169/c-elegans-mrp-5-exports-vitamin-b12-from-mother-to-offspring-to-support-embryonic-development
#19
Huimin Na, Olga Ponomarova, Gabrielle E Giese, Albertha J M Walhout
Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate. In the nematode Caenorhabditis elegans, maternally supplied vitamin B12 is required for the development of offspring. However, the mechanism for exporting vitamin B12 from the mother to the offspring is not yet known. Here, we use RNAi of more than 200 transporters with a vitamin B12-sensor transgene to identify the ABC transporter MRP-5 as a candidate vitamin B12 exporter...
March 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29560851/association-between-pre-pregnancy-weight-status-and-maternal-micronutrient-status-in-early-pregnancy
#20
Judith M Scholing, Margreet R Olthof, Femkje Am Jonker, Tanja Gm Vrijkotte
OBJECTIVE: Inadequate maternal micronutrient status during pregnancy can lead to short- and long-term health risks for mother and offspring. The present study investigated the association between pre-pregnancy weight status and micronutrient status during pregnancy. DESIGN: Maternal blood samples were collected during early pregnancy (median 13, interquartile range 12-15 weeks) and were assayed for serum folate, ferritin, Fe and vitamin B12. Regression modelling was used to assess the association between pre-pregnancy underweight, normal weight, overweight and obesity, and micronutrient levels, as well as the odds for deficiencies...
March 21, 2018: Public Health Nutrition
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