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Vitamin B12 deficiency

Konika Sharma, Karn Wijarnpreecha, Nancy Merrell
Diphyllobothrium latum ( D. latum ) infection in humans is uncommon in the United States. Although there has been a drastic decline in the report of D. latum infection in this region, physicians should be aware of an uncommon presentation and its clinical relevance. We report a case of 55-year-old female of Ecuadorian/Peruvian origin who presented with an unknown cause of chronic right lower quadrant abdominal pain for 2 months without other particular symptoms. Initial workup revealed evidence of iron deficiency anemia, and stool occult blood test was positive...
June 2018: Gastroenterology Research
Amanda M Henderson, Daven C Tai, Rika E Aleliunas, Abeer M Aljaadi, Melissa B Glier, Eric E Xu, Joshua W Miller, C Bruce Verchere, Tim J Green, Angela M Devlin
Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B12 , on adult, female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B12 ), supplemental folic acid with no B12 (SFA-B12 ), or supplemental folic acid with adequate B12 (SFA+B12 )...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Wendy Schijns, Lisanne T Schuurman, Alida Melse-Boonstra, Cees J H M van Laarhoven, Frits J Berends, Edo O Aarts
BACKGROUND: One of the side effects of bariatric surgery is the risk of vitamin and mineral deficiencies. Vitamin B12, vitamin D, folate, and iron deficiencies are especially common among Roux-en-Y gastric bypass patients. OBJECTIVE: To examine the effectiveness of a specialized multivitamin supplement for Roux-en-Y gastric bypass patients on deficiencies the first 3 years postoperatively, retrospectively in a large, prospectively collected cohort. SETTING: Large specialized bariatric hospital...
April 3, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun
BACKGROUND/PURPOSE: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA+ RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs- RAS/BD) patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA+ RAS/BD patients, 41 Abs- RAS/BD patients, and 126 healthy control subjects...
June 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Rupak Shivakoti, Erin R Ewald, Nikhil Gupte, Wei-Teng Yang, Cecilia Kanyama, Sandra W Cardoso, Breno Santos, Khuanchai Supparatpinyo, Sharlaa Badal-Faesen, Javier R Lama, Umesh Lalloo, Fatima Zulu, Jyoti S Pawar, Cynthia Riviere, Nagalingeswaran Kumarasamy, James Hakim, Richard Pollard, Barbara Detrick, Ashwin Balagopal, David M Asmuth, Richard D Semba, Thomas B Campbell, Jonathan Golub, Amita Gupta
BACKGROUND & AIMS: Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation. METHODS: We conducted a secondary analysis of a random sub-cohort sample (n = 270) from a multinational randomized trial of cART regimen efficacy among 1571 cART-naïve adults...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Saskia Lm van Loon, Anna M Wilbik, Uzay Kaymak, Edwin R van den Heuvel, Volkher Scharnhorst, Arjen-Kars Boer
Background Methylmalonic acid (MMA) can detect functional vitamin B12 deficiencies as it accumulates early when intracellular deficits arise. However, impaired clearance of MMA from blood due to decreased glomerular filtration rate (eGFR) also results in elevated plasma MMA concentrations. Alternative to clinical trials, a data mining approach was chosen to quantify and compensate for the effect of decreased eGFR on MMA concentration. Methods Comprehensive data on patient's vitamin B12 , eGFR and MMA concentrations were collected ( n = 2906)...
January 1, 2018: Annals of Clinical Biochemistry
William Egan, Eric Steinberg, Jeremy Rose
A 24-year-old female, otherwise healthy, presented to the Emergency Department (ED) with difficulty walking and bilateral leg pain. The patient was a recreational nitrous oxide (NO2 ) user, also known as "whippets" or simply nitrous. Neurologic examination demonstrated an unsteady gait and positive Romberg sign along with normal deep tendon reflexes and normal muscle strength in upper and lower extremities. Laboratory results demonstrated macrocytic erythropoiesis, reduced B12 , elevated homocysteine, and elevated methylmalonic acid...
May 24, 2018: American Journal of Emergency Medicine
H J M Smelt, S Pouwels, M Said, J F Smulders
The rising rates of bariatric surgery (BS) are accompanied by neurological complications related to nutrient deficiencies. One of the risk factors for neurological complications in BS patients is poor vitamin and mineral supplementation. Prevention, diagnosis and treatment of these disorders are necessary parts of lifelong care after BS. Particularly important for optimal functioning of the nervous system are vitamin B1 , B6 , B12 (cobalamin), E, copper and possibly vitamin B11 (folic acid). In this case report, we narrate about a patient with anaemia and multiple vitamin and mineral deficiencies after Roux-en-Y gastric bypass (RYGB) with an alimentary limb of 150 cm and a biliopancreatic limb of 100 cm...
May 31, 2018: Clinical Obesity
Musarrat Riaz, Fareeha Shaikh, Asher Fawwad, Rubina Hakeem, A Samad Shera, Graham A Hitman, Bishwajit Bhowmik, Nayla Christina do Vale Moreira, Abdul Basit, Akhtar Hussain
Objective: To explore the impact of maternal body weight on maternal nutrition and micronutrient status in early pregnancy and potential impact on metabolic status in newborns. Methodology: The EU FP7 project GIFTS was conducted from Jan 2012 to May 2014. Demographic details and anthropometric measurements of women in the first trimester of pregnancy were obtained. Blood samples were collected for OGTT, insulin, lipid profile, serum folate, ferritin, vitamin D, vitamin B12, and red cell folate...
2018: Journal of Diabetes Research
Safia Fatima, Ayesha Hafeez, Aamir Ijaz, Naveed Asif, Afshan Awan, Ambreen Sajid
Classical homocystinuria, also known as cystathionine beta synthase deficiency, is a rare disorder of methionine metabolism, leading to an abnormal accumulation of homocysteine and its metabolites in blood and urine. A young child with homocystinuria is discussed, who presented with behavioral abnormalities, involuntary movement, mental retardation, and decreased vision since birth. The diagnosis of homocystinuria was not made at initial presentation. Subtle phenotypic features with developmental delay and MRI brain finding of bilateral medially dislocated lens, eventually provided the first indication at five years of age...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Ana Lívia de Oliveira, Ana Paula Boroni Moreira, Michele Pereira Netto, Isabel Cristina Gonçalves Leite
Little is known about the nutritional status and dietary habits of persons with an intestinal stoma, and no specific dietary guidelines have been established. A cross-sectional study was conducted among patients of a Stoma Patient Health Care Service in Juiz de Fora, Brazil, to compare the nutritional status of persons with an ileostomy or colostomy and to evaluate which foods are avoided most frequently and why. Anthropometric measurements (weight, height, arm circumference, and triceps and subscapular skinfold thickness) and body fat were assessed...
May 2018: Ostomy/wound Management
Bernadette Carolyn Baker, Dexter Hayes, Rebecca Lee Jones
Micronutrient deficiencies are common in pregnant women due to low dietary intake and increased requirements for fetal development. Low maternal micronutrient status is associated with a range of pregnancy pathologies involving placental dysfunction, including fetal growth restriction (FGR), small for gestational age (SGA), pre-eclampsia and preterm birth. However, clinical trials commonly fail to convincingly demonstrate beneficial effects of supplementation of individual micronutrients, attributed to heterogeneity and insufficient power, potential interactions and lack of mechanistic knowledge of effects on the placenta...
May 29, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Hafsa Majid, Lena Jafri, Aysha Habib Khan, Zeba Zulfiqar Ali, Azeema Jamil, Nasir Yusufzai, Midhat Fatimah, Bushra Afroze
OBJECTIVE: To determine the frequency of disorders leading to methylmalonic acidurias. METHODS: This cross-sectional study was conducted from January 2013 to April 2016 at the Aga Khan University Hospital, Karachi, and comprised patients diagnosed with methylmalonic acidurias based on urine organic acid analysis. Clinical history and biochemical data was collected from the biochemical genetics laboratory requisition forms. Organic acid chromatograms of all the subjects were critically reviewed by a biochemical pathologist and a metabolic physician...
April 2018: JPMA. the Journal of the Pakistan Medical Association
Halil Ibrahim Atasoy, Guler Bugdayci
BACKGROUND: Zinc deficiency is thought to be common among children; its predictive capacity for anaemia is unclear. Thus, our study aimed to find children with zinc deficiency among school children, and investigate the association between zinc status and haemoglobin levels together with other estimates of anaemia. METHODS: For this case-control study, three hundred and forty-nine children out of 483 children between 6.5 and 14.8 years old were included from primary schools...
May 27, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Jérèmy Willekens, Sébastien Hergalant, Grégory Pourié, Fabian Marin, Jean-Marc Alberto, Lucie Georges, Justine Paoli, Christophe Nemos, Jean-Luc Daval, Jean-Louis Guéant, Brigitte Leininger-Muller, Natacha Dreumont
Gestational methyl donor (especially B9 and B12 vitamins) deficiency is involved in birth defects and brain development retardation. The underlying molecular mechanisms that are dysregulated still remain poorly understood, in particular in the cerebellum. As evidenced from previous data, females are more affected than males. In this study, we therefore took advantage of a validated rat nutritional model and performed a microarray analysis on female progeny cerebellum, in order to identify which genes and molecular pathways were disrupted in response to methyl donor deficiency...
May 26, 2018: Molecular Neurobiology
P van Hagen, R de Jonge, M I van Berge Henegouwen, G J Hötte, E P van der Stok, J Lindemans, J J B van Lanschot, B P L Wijnhoven
The aim of this study is to determine the prevalence and incidence of vitamin B12 deficiency after esophagectomy for cancer. It is unknown if patients after esophagectomy with gastric tube reconstruction are at an increased risk for vitamin B12 deficiency. A cross-sectional cohort (group A) and a prospective cohort (group B) of patients who underwent esophagectomy for cancer in two tertiary referral centers in the Netherlands were included. Serum levels of holo-transcobalamin (Holo-TC) and methyl malonic acid (MMA) were determined...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Gabriele Röhrig, Ines Gütgemann, Gerald Kolb, Andreas Leischker
The interdisciplinary symposium of the working group "anemia in the aged" on the occasion of the annual conference of the German Society of Geriatrics focused this year on vitamin B12 deficiency in aged patients. Experts from hematopathology, clinical geriatrics and geriatric hematology presented the case of a 78-year-old woman and an interdisciplinary discussion was held on the epidemiology, clinical aspects as well as diagnostic and therapeutic steps. This article reviews the symposium on vitamin B12 deficiency in the aged in the context of the currently available literature...
June 2018: Zeitschrift Für Gerontologie und Geriatrie
Amir Emamifar, Inger Marie Jensen Hansen
To investigate the impact of comorbid diseases on rheumatoid arthritis (RA) outcome.All patients diagnosed with RA since 2006, who were registered in our local Danbio registry, were included in this cohort study. Patients' demographics, serology results, and Disease Activity Score in 28 joints-C-reactive protein (DAS28-CRP) at the time of diagnosis and after 4 months of treatment initiation were collected. Patients' electronic hospital records were evaluated for a positive history of thyroid diseases, diabetes mellitus, primary hyperparathyroidism, vitamin B12 deficiency, and the presence of other diagnosed autoimmune diseases...
May 2018: Medicine (Baltimore)
Ergin Arslan, Mesut Sipahi, Oktay Banli
PURPOSE: We evaluated early results of this new procedure of transit loop bipartition with sleeve gastrectomy (TLB-SG), making a comparison with transit bipartition with sleeve gastrectomy. MATERIALS AND METHODS: Between January 2017 and September 2017, 22 patients have undergone transit bipartition with sleeve gastrectomy or TLB-SG surgery in our clinic. Patients' body mass index, excess body mass index loss, and HOMA-IR were calculated before and after the surgical operation...
May 18, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
Mohammad Altamimi
Background: Autism spectrum disorder is a neurodevelopmental disorder. It is believed that the cause of autism is multifactorial, where genetic predispositions interact with environmental factors. In this context, micronutrients play a crucial role. Objective: To present evidence on current micronutrient status in Palestine and highlight its possible role in increasing problems of neurodevelopment disorders in general and autism in particular. Method: Analytical review of results...
2018: Nutrition and Metabolic Insights
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