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Vitamin B12 deficiency

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https://www.readbyqxmd.com/read/27904562/hyperhomocysteinemia-low-vitamin-b12-and-low-folic-acid-are-risk-factors-of-cerebral-vascular-thrombosis-in-northwest-iran
#1
Ali Akbar Taheraghdam, Nooriyeh Dalirakbari, Mohammad Khalili, Madjid Soltani, Saeid Sadeghieh Ahari
BACKGROUND: Cerebral vascular thrombosis (CVT) is the thrombosis of intracranial and sinuses. The aim of this is to estimate of risk of low folic acid, low vitamin B12, and hyperhomocysteinemia (hyper-Hcys) for CVT. MATERIALS AND METHODS: A total of 24 patients with CVT and 36 healthy controls participated in a cross-sectional case-control study. The deficient levels of folic acid and vitamin B12 defined as <10(th) percentile of folic acid and vitamin B12 level and hyper-Hcys was defined as >90(th) percentile of homocysteine of control group...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27898216/characterization-of-prostacyclin-associated-leg-pain-in-patients-with-pulmonary-arterial-hypertension
#2
Gabriel L Pagani-Estévez, Keith M Swetz, Michael D McGoon, Robert P Frantz, Susan K Tointon, Ann M Karnyski, Louise A Durst, James C Watson
RATIONALE: Prostacyclin-associated leg pain is a potentially debilitating adverse effect of prostacyclin therapy for patients with pulmonary arterial hypertension (PAH). However, to our knowledge, this entity has not been systematically studied. OBJECTIVE: To characterize the clinical features and metabolic risk factors for prostacyclinassociated leg pain. METHODS: At one academic medical center we assembled and analyzed a case series of patients with PAH and prostacyclin-associated leg pain...
November 29, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27895843/severe-anemia-in-malawian-children
#3
Job Cj Calis, Kamija S Phiri, E Brian Faragher, Bernard J Brabin, Imelda Bates, Luis E Cuevas, Rob J de Haan, Ajib I Phiri, Pelani Malange, Mirriam Khoka, Paul Jm Hulshof, Lisette van Lieshout, Marcel Ghm Beld, Yik Y Teo, Kirk A Rockett, Anna Richardson, Dominic P Kwiatkowski, Malcolm E Molyneux, Michaël Boele van Hensbroek
BACKGROUND: Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied. METHODS: We conducted a case-control study of 381 preschool children with severe anemia (hemoglobin concentration, <5.0 g per deciliter) and 757 preschool children without severe anemia in urban and rural settings in Malawi. Causal factors previously associated with severe anemia were studied. The data were examined by multivariate analysis and structural equation modeling...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27890954/prevalence-of-vitamin-b12-and-folic-acid-deficiency-in-hiv-positive-patients-and-its-association-with-neuropsychiatric-symptoms-and-immunological-response
#4
Prabha M R Adhikari, Mukta N Chowta, John T Ramapuram, Satish Rao, Karthik Udupa, Sahana Devdas Acharya
BACKGROUND: Deficiency of micronutrients is prevalent even before the development of symptoms of HIV disease and is associated with accelerated HIV disease progression. AIMS: This study evaluates the prevalence of folate and Vitamin B12 deficiency in HIV-positive patients with or without tuberculosis (TB) and its association with neuropsychiatric symptoms and immunological response. SETTINGS AND DESIGN: Cross-sectional, observational study in an outpatient setting...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27889885/investigating-factors-involved-in-post-laparoscopic-sleeve-gastrectomy-lsg-neuropathy
#5
Almaha Alsabah, Salman Al Sabah, Suleiman Al-Sabah, Ahmad Al-Serri, Eliana Al Haddad, Waleed M Renno
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. Due to the rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine biochemical and hormonal factors that are associated with neuropathy post-LSG. METHODS: Thirty-two patients were included: 16 patients with neuropathy in the neuropathic group (NG) and 16 patients without neuropathy in the control group (CG)...
November 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27885843/current-evaluation-and-management-of-anaemia-in-patients-with-inflammatory-bowel-disease
#6
Julia Martin, Heinfried H Radeke, Axel Dignass, Jürgen Stein
Anaemia is a common extraintestinal manifestation in IBD patients and considerably impacts disease prognosis, hospitalisation rates and time lost from work. While iron deficiency anaemia is predominant, combinations of haematimetric and biochemical markers enable detection and targeted therapy of other aetiologies including vitamin B12/folic acid deficiencies, haemolysis, myelosuppression and pharmacotherapies. Areas covered: Current literature was searched for articles focusing on aetiology, diagnostics and therapy of anaemia in IBD...
November 25, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27876556/homocysteine-and-disease-causal-associations-or-epiphenomenons
#7
REVIEW
Luciana Hannibal, Henk J Blom
Nutritional and genetic deficiencies of folate and vitamin B12 lead to elevation of cellular homocysteine (Hcy), which translates in increased plasma Hcy. The sources and role of elevated plasma Hcy in pathology continues to be a subject of intense scientific debate. Whether a cause, mediator or marker, little is known about the molecular mechanisms and interactions of Hcy with cellular processes that lead to disease. The use of folic acid reduces the incidence of neural tube defects, but the effect of Hcy-lowering interventions with folic acid in cardiovascular disease and cognitive impairment remains controversial...
November 19, 2016: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/27874946/visual-and-somotosensory-evoked-potentials-in-asymptomatic-patients-with-vitamin-b12-deficiency
#8
B Gökçe Çokal, H N Güneş, S K Güler, T K Yoldaş
OBJECTIVE: Vitamin B12 deficiency may be asymptomatic or present with a wide range of neurological and hematological disorders. Our aim in this study is to evaluate visual (VEP) and somatosensory evoked potential (SEP) parameters in patients with vitamin B12 deficiency who had no clinical evidence of visual impairment or neurological syndrome findings and compare the findings with healthy controls to determine whether there is a correlation between VEP and SEP parameters and serum vitamin B12 levels...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27867908/erratum-study-of-vitamin-b12-deficiency-and-peripheral-neuropathy-in-metformin-treated-early-type-2-diabetes-mellitus
#9
(no author information available yet)
[This corrects the article on p. 631 in vol. 20, PMID: 27730072.].
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27858373/vitamin-b12-administration-by-subcutaneous-catheter-device-in-a-cobalamin-a-cbla-patient
#10
E Maines, G Morandi, G Gugelmo, F Ion-Popa, N Campostrini, A Pasini, M Vincenzi, F Teofoli, M Camilot, A Bordugo
Cobalamin A deficiency (cblA) is an inherited disorder of intracellular cobalamin metabolism, caused by impaired 5'-deoxy-adenosylcobalamin (AdoCbl) synthesis. Hydroxocobalamin (OHCbl) is the cornerstone of cblA treatment because vitamin B12 may completely restore AdoCbl deficiency. Parenteral administration, intravenous, subcutaneous or intramuscular, is generally required to achieve effect. Daily injections represent a problem for the parents and the caregivers, and this may lead to poor compliance and scarce adherence to the long-term treatment...
November 18, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27854316/causes-consequences-and-public-health-implications-of-low-b-vitamin-status-in-ageing
#11
REVIEW
Kirsty Porter, Leane Hoey, Catherine F Hughes, Mary Ward, Helene McNulty
The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis...
November 16, 2016: Nutrients
https://www.readbyqxmd.com/read/27853271/foetal-programming-by-methyl-donor-deficiency-produces-steato-hepatitis-in-rats-exposed-to-high-fat-diet
#12
Anaïs Bison, Aude Marchal-Bressenot, Zhen Li, Ilef Elamouri, Eva Feigerlova, Lu Peng, Remi Houlgatte, Bernard Beck, Gregory Pourié, Jean-Marc Alberto, Remy Umoret, Guillaume Conroy, Jean-Pierre Bronowicki, Jean-Louis Guéant, Rosa-Maria Guéant-Rodriguez
Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors (folate and vitamin B12) during gestation and lactation is frequent in humans and produces foetal programming effects of metabolic syndrome, with small birth weight and liver steatosis at day 21 (d21), in rat pups. We investigated the effects of fetal programming on liver of rats born from deficient mothers (iMDD) and subsequently subjected to normal diet after d21 and high fat diet (HF) after d50...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846467/red-blood-cell-distribution-width-predicts-homocysteine-levels-in-adult-population-without-vitamin-b12-and-folate-deficiencies
#13
You-Fan Peng, Guo-Gang Pan
OBJECTIVES: Our aim in this study was to explore the relationship between red blood cell distribution width (RDW) and homocysteine levels in an adult population. METHODS: The study included 344 subjects who underwent health check-up in our hospital. The demographic characteristics and laboratory parameters of participants were grouped in accordance with tertiles of RDW. RESULTS: An increase of homocysteine levels was found from the first to third tertiles of RDW in all participants...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27843871/reversible-ecchymosis-and-hyperpigmented-lesions-a-rare-presentation-of-dietary-vitamin-b12-deficiency
#14
Hans Raj Pahadiya, Manoj Lakhotia, Sukhdev Choudhary, Gopal Raj Prajapati, Sangeeta Pradhan
A 40-year-old male presented because of generalized weakness, fatigability, and hyperpigmentation with ecchymosis, he was diagnosed to have dietary Vitamin B12 deficiency anemia. The hyperpigmentation and ecchymosis lesions resolved after Vitamin B12 supplementation. Beside hyperpigmented lesion on the skin, the presence of ecchymosis is a very rare manifestation of the disease. Thrombocytopenia in Vitamin B12 deficiency anemia rarely leads to ecchymosis.
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27843799/etiological-causes-of-pancytopenia-a-report-of-137-cases
#15
Osman Yokuş, Habip Gedik
OBJECTIVE: The aim of this study is to evaluate the etiological causes of pancytopenia in patients who were admitted to the hematology ward due to pancytopenia. MATERIALS AND METHODS: All patients who were admitted to the hematology ward of Ministry of Health Istanbul Training and Research Hospital due to pancytopenia between 2013 and 2015 were retrospectively evaluated regarding etiological causes. RESULTS: A total of 137 patients was evaluated...
October 2016: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/27827854/nutritional-and-micronutrient-status-of-female-workers-in-a-garment-factory-in-cambodia
#16
Jan Makurat, Hanna Friedrich, Khov Kuong, Frank T Wieringa, Chhoun Chamnan, Michael B Krawinkel
BACKGROUND: Concerns about the nutritional status of Cambodian garment workers were raised years ago but data are still scarce. The objectives of this study are to examine the nutritional, hemoglobin and micronutrient status of female workers in a garment factory in Phnom Penh, Cambodia, and to assess if body mass index is associated with hemoglobin and/or micronutrient status. METHODS: A cross-sectional survey was conducted among 223 female workers (nulliparous, non-pregnant) at a garment factory in Phnom Penh...
November 2, 2016: Nutrients
https://www.readbyqxmd.com/read/27825815/anemia-and-hematinic-deficiencies-in-anti-gastric-parietal-cell-antibody-positive-or-all-autoantibodies-negative-recurrent-aphthous-stomatitis-patients
#17
Hung-Pin Lin, Yu-Hsueh Wu, Yi-Ping Wang, Yang-Che Wu, Julia Yu-Fong Chang, Andy Sun
BACKGROUND/PURPOSE: Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients. METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects...
November 5, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27825814/anemia-and-hematinic-deficiencies-in-anti-gastric-parietal-cell-antibody-positive-and-negative-recurrent-aphthous-stomatitis-patients-with-anti-thyroid-antibody-positivity
#18
Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Hsin-Ming Chen, Andy Sun
BACKGROUND/PURPOSE: Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA-/TGA/TMA/RAS patients). METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA-/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs-/RAS patients), and 342 healthy control subjects...
November 5, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27825397/micronutrient-intake-in-advanced-age-te-pu%C3%A4-waitanga-o-ng%C3%A4-tapuwae-kia-ora-tonu-life-and-living-in-advanced-age-a-cohort-study-in-new-zealand-lilacs-nz
#19
Carol Wham, Ruth Teh, Simon A Moyes, Anna Rolleston, Marama Muru-Lanning, Karen Hayman, Ngaire Kerse, Ashley Adamson
A high prevalence of undernutrition has previously been reported in indigenous Māori (49 %) and non-Māori (38 %) octogenarians and may be associated with risk of micronutrient deficiencies. We examined vitamin and mineral intakes and the contributing food sources among 216 Māori and 362 non-Māori participating in Life and Living to Advanced age a Cohort Study in New Zealand, using a repeat 24-h multiple-pass recall. More than half of the Māori and non-Māori participants had intakes below the estimated average requirement from food alone for Ca, Mg and Se...
November 9, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27823800/a-randomized-placebo-controlled-trial-of-vitamin-b12-supplementation-to-prevent-cognitive-decline-in-older-diabetic-people-with-borderline-low-serum-vitamin-b12
#20
Timothy Kwok, Jenny Lee, Ronald C Ma, Samuel Y Wong, Kenny Kung, Augustine Lam, C S Ho, Vivian Lee, John Harrison, Linda Lam
BACKGROUND & AIMS: Older diabetic people are at risk of cognitive decline. Vitamin B12 deficiency in older people is associated with cognitive impairment and Alzheimer's disease. Vitamin B12 deficiency may therefore contribute to cognitive decline in older diabetic people. We therefore performed a randomized placebo-controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with mild vitamin B12 deficiency. METHODS: 271 diabetic non-demented outpatients aged 70 years or older with plasma vitamin B12 150-300 pmol/L in outpatient clinics were randomly assigned to take either methylcobalamin 1000 μg or two similar looking placebo tablets once daily for 27 months...
October 27, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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