keyword
MENU ▼
Read by QxMD icon Read
search

Gp130

keyword
https://www.readbyqxmd.com/read/29629897/ectopic-upregulation-of-membrane-bound-il6r-drives-vascular-remodeling-in-pulmonary-arterial-hypertension
#1
Yuichi Tamura, Carole Phan, Ly Tu, Morane Le Hiress, Raphaël Thuillet, Etienne-Marie Jutant, Elie Fadel, Laurent Savale, Alice Huertas, Marc Humbert, Christophe Guignabert
Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles leading to the narrowing of the lumen, right heart failure, and death. Although most studies have supported the notion of a role for IL-6/glycoprotein 130 (gp130) signaling in PAH, it remains unclear how this signaling pathway determines the progression of the disease. Here, we identify ectopic upregulation of membrane-bound IL-6 receptor (IL6R) on PA-SMCs in PAH patients and in rodent models of pulmonary hypertension (PH) and demonstrate its key role for PA-SMC accumulation in vitro and in vivo...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29626088/granulocytes-are-unresponsive-to-il-6-due-to-an-absence-of-gp130
#2
Andrew N Wilkinson, Kate H Gartlan, Greg Kelly, Luke D Samson, Stuart D Olver, Judy Avery, Nienke Zomerdijk, Siok-Keen Tey, Jason S Lee, Slavica Vuckovic, Geoffrey R Hill
IL-6 mediates broad physiological and pathological effects through its receptor signal transducing unit gp130. Due to the reportedly wide cellular expression of gp130, IL-6 is thought to signal ubiquitously via gp130 complex formation with membrane-bound IL-6Rα or soluble IL-6Rα. gp130 signaling primarily induces p-STAT3 and p-STAT1. In contrast to the previous dogma, we show in this article that circulating mouse and human granulocytes are unable to induce p-STAT3 or p-STAT1 after stimulation with IL-6 or an IL-6/soluble IL-6R complex...
April 6, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29617629/effects-of-interleukin-6-on-posterior-capsular-opacification
#3
Bo Ma, Lan Yang, Ruihua Jing, Jie Liu, Yumeng Quan, Qiaoyan Hui, Jingming Li, Li Qin, Cheng Pei
The purpose of this work was to determine the effects of interleukin-6 (IL-6) on the development of posterior capsular opacification (PCO) in vitro and in vivo. Western blot and real-time PCR were used to test the IL-6-induced epithelial-mesenchymal transition (EMT) marker α-smooth muscle actin (α-SMA), the extracellular matrix (ECM) markers fibronectin (Fn) and type I collagen (COL-1), transforming growth factor β2 (TGF-β2 ), and the activation and role of the JAK/STAT3 signaling pathway in human lens epithelial cells (HLECs)...
April 1, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29580104/soluble-glycoprotein-130-is-inversely-related-to-severity-of-coronary-atherosclerosis
#4
Alexandra A Korotaeva, Daria A Chepurnova, Yulia A Shuvalova, Irina V Zhitareva, Elena V Samoilova, Nina V Prokazova
PURPOSE: Recent studies indicate that the effects of interleukin 6 (IL-6) realized via soluble IL-6 receptor (sIL-6R) facilitate the development of various pathological processes. Soluble gp130 (sgp130) is a naturally occurring inhibitor of signal transduction via this pathway. In this study, we assessed the relationship between circulating levels of IL-6, sIL-6R and sgp130 and severity of coronary atherosclerosis in patients with stable coronary artery disease (CAD). METHODS: Plasma levels of IL-6, sIL-6R and sgp130 were measured in patients with atherosclerotic coronary lesions (n = 128, group 1) and with intact coronary arteries (n = 48, group 2)...
March 27, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29559558/the-balance-of-interleukin-il-6-il-6-soluble-il-6-receptor-il-6r-and-il-6-sil-6r-sgp130-complexes-allows-simultaneous-classic-and-trans-signaling
#5
Paul Baran, Selina Hansen, Georg H Waetzig, Mohammad Akbarzadeh, Larissa Lamertz, Heinrich J Huber, M Reza Ahmadian, Jens M Moll, Jürgen Scheller
Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively. Whereas inflammation triggers IL-6 expression, eventually rising to nanogram per mL serum levels, soluble IL-6R (sIL-6R) and soluble gp130 (sgp130) are constitutively present in the upper nanogram per mL range. Calculations based on intermolecular affinities have suggested that systemic IL-6 is immediately trapped in IL-6:sIL-6R and IL-6:sIL-6R:sgp130 complexes, indicating that sIL-6R and sgp130 constitute a buffer system that increases the serum half-life of IL-6 or restricts systemic IL-6 signaling...
March 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29533934/two-n-linked-glycans-differentially-control-maturation-trafficking-and-proteolysis-but-not-activity-of-the-il-11-receptor
#6
Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers
BACKGROUND/AIMS: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 130 (gp130). N-linked glycosylation, a post-translational modification where complex oligosaccharides are attached to the side chain of asparagine residues, is often important for stability, folding and biological function of cytokine receptors...
March 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29515523/igf-binding-protein-5-induces-cell-senescence
#7
REVIEW
Fumihiro Sanada, Yoshiaki Taniyama, Jun Muratsu, Rei Otsu, Hideo Shimizu, Hiromi Rakugi, Ryuichi Morishita
Cellular senescence is the complex process of deterioration that drives the aging of an organism, resulting in the progressive loss of organ function and eventually phenotypic aging. Senescent cells undergo irreversible growth arrest, usually by inducing telomere shortening. Alternatively, senescence may also occur prematurely in response to various stress stimuli, such as oxidative stress, DNA damage, or activated oncogenes. Recently, it has been shown that IGF binding protein-5 (IGFBP-5) with the induction of the tumor suppressor p53 is upregulated during cellular senescence...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29511087/the-ab-loop-and-d-helix-in-binding-site-iii-of-human-oncostatin-m-osm-are-required-for-osm-receptor-activation
#8
Juan M Adrian-Segarra, Natalie Schindler, Praveen Gajawada, Holger Lörchner, Thomas Braun, Jochen Pöling
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are closely related members of the interleukin-6 (IL-6) cytokine family. Both cytokines share a common origin and structure, and both interact through a specific region, termed binding site III, to activate a dimeric receptor complex formed by glycoprotein 130 (gp130) and LIF receptor (LIFR) in humans. However, only OSM activates the OSM receptor (OSMR)/gp130 complex. The molecular features that enable OSM to specifically activate the OSMR are currently unknown...
March 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29505662/exogenous-melatonin-protects-small-for-size-liver-grafts-by-promoting-monocyte-infiltration-and-releases-interleukin-6
#9
Zhuolun Song, Bostjan Humar, Anurag Gupta, Eleonora Maurizio, Nathalie Borgeaud, Rolf Graf, Pierre-Alain Clavien, Yinghua Tian
Defective regeneration of small-for-size (SFS) liver remnants and partial grafts remains a key limiting factor in the application of liver surgery and transplantation. Exogenous melatonin (MLT) has protective effects on hepatic ischemia reperfusion injury (IRI), but its influence on graft regeneration is unknown. The aim of the study is to investigate the role of MLT in IRI and graft regeneration in settings of partial liver transplantation. We established three mouse models to study hepatic IRI and regeneration associated with partial liver transplantation: (I) IR+PH group: 60 min liver ischemia (IR) plus 2/3 hepatectomy (PH); (II) IR+exPH group: 60 min liver IR plus extended hepatectomy (exPH) associated with the SFS syndrome; (III) SFS-LT group: Arterialized 30% SFS liver transplant...
March 5, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29500240/murine-%C3%AE-herpesvirus-68-induces-severe-lung-inflammation-in-il-27-deficient-mice-with-liver-dysfunction-preventable-by-oral-neomycin
#10
Kyosuke Kanai, Ah-Mee Park, Akiko Watanabe, Tomohiro Arikawa, Teruhito Yasui, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
IL-27 is an immunoregulatory cytokine consisting of p28 and EBI3. Its receptor also has two subunits, WSX1 and gp130. Although IL-27 promotes Th1 differentiation in naive T cells, it also induces IL-10 expression in effector Th1 cells to curtail excessive immune responses. By using p28-deficient mice and WSX1-deficient mice (collectively called IL-27-deficient mice), we examined the role of IL-27 in primary infection by murine γ-herpesvirus 68 (MHV68), a murine model of EBV. Upon airway infection with MHV68, IL-27-deficient mice had more aggravated lung inflammation than wild-type mice, although MHV68 infection per se was better controlled in IL-27-deficient mice...
March 2, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29497424/interleukin-il-6-inhibits-il-27-and-il-30-mediated-inflammatory-responses-in-human-monocytes
#11
Carlene Petes, Mélissa K Mariani, Yawen Yang, Nathalie Grandvaux, Katrina Gee
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners. Thus far, functions of IL-30 have not been fully elucidated in human cells. We demonstrate that like IL-27, IL-30 upregulated TLR4 expression to enhance lipopolysaccharide-induced TNF-α production in human monocytes; however, these IL-30-mediated activities did not reach the same levels of cytokine induction compared to IL-27...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29491480/osteoarthritis-targeting-gp130-aids-cartilage-repair
#12
Joanna Collison
No abstract text is available yet for this article.
March 1, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29488250/the-m2-triangle-gp130-binding-cytokines-drive-macrophages-to-promote-tumor-growth
#13
Dominik Rückerl, Paula I Seoane
No abstract text is available yet for this article.
February 28, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29446854/overexpression-of-il-35-in-intrahepatic-cholangiocarcinoma-isa-prognostic-indicator-after-curative-resection
#14
Meixia Zhang, Wei Gan, Chuyu Jing, Susu Zheng, Juan Zhang, Hujia Shen, Xin Xu, Jiajia Lin, Boheng Zhang, Shuangjian Qiu
Interleukin-35 (IL-35) is implicated in tumorigenesis, but the exact impact on intrahepatic cholangiocarcinoma (ICC) is not clearly. The aim of present study was to explore the specific effect of IL-35 on patient prognosis. Additionally, we formulated an effective prognostic nomogram for ICC patients after curative resection. Immunohistochemistry (IHC) was applied to explore IL-35 expression as well as IL-35R in 102 ICC patients. The results showed IL-35 was highly expressed in ICC tumor tissues and was positively associated with lymph node metastasis, TNM stage and vascular invasion and was independent prognostic factor for patients' OS and RFS...
February 15, 2018: Cancer Science
https://www.readbyqxmd.com/read/29436471/drug-induced-modulation-of-gp130-signalling-prevents-articular-cartilage-degeneration-and-promotes-repair
#15
Ruzanna Shkhyan, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Yifan Yu, Mila Scheinberg, Nicholas W Banks, Sean Limfat, Arthur Chernostrik, Carlos Eduardo Franciozi, Mohammad Parvez Alam, Varghese John, Ling Wu, Gabriel B Ferguson, Ali Nsair, Frank A Petrigliano, C Thomas Vangsness, Kanagasabai Vadivel, Paul Bajaj, Liming Wang, Nancy Q Liu, Denis Evseenko
OBJECTIVE: Human adult articular cartilage (AC) has little capacity for repair, and joint surface injuries often result in osteoarthritis (OA), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. Inflammation mediated by interleukin (IL)-6 family cytokines has been identified as a critical driver of proarthritic changes in mouse and human joints, resulting in a feed-forward process driving expression of matrix degrading enzymes and IL-6 itself. Here we show that signalling through glycoprotein 130 (gp130), the common receptor for IL-6 family cytokines, can have both context-specific and cytokine-specific effects on articular chondrocytes and that a small molecule gp130 modulator can bias signalling towards anti-inflammatory and antidegenerative outputs...
February 7, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29417587/hyperactive-gp130-stat3-driven-gastric-tumourigenesis-promotes-submucosal-tertiary-lymphoid-structure-development
#16
David G Hill, Liang Yu, Hugh Gao, Jesse J Balic, Alison West, Hiroko Oshima, Louise McLeod, Masanobu Oshima, Awen Gallimore, Kimberley D'Costa, Prithi S Bhathal, William Sievert, Richard L Ferrero, Brendan J Jenkins, Gareth W Jones
Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by chronic inflammation, as well as in certain inflammation-associated cancers where they are prognostic of improved patient survival. However, the mechanisms that govern the development of tumour-associated TLSs remain ill-defined. Here, we observed tumour-associated TLSs in a preclinical mouse model (gp130F/F ) of gastric cancer, where tumourigenesis is dependent on hyperactive STAT3 signalling through the common IL-6 family signalling receptor, gp130...
February 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29410184/interleukin-6-potentiates-fc%C3%AE%C2%B5ri-induced-pgd2-biosynthesis-and-induces-vegf-from-human-in-situ-matured-skin-mast-cells
#17
Cody McHale, Zahraa Mohammed, Juline Deppen, Gregorio Gomez
BACKGROUND: Interleukin-6 is a gp130 utilizing cytokine that is consistently associated with allergic diseases like asthma and urticaria in humans where mast cells are known to play a critical role. However, the role of IL-6 in allergic disease in not known. IL-6 was reported to enhance degranulation of in vitro-derived mast cells, but the effect of IL-6 on mediator release from human in situ-matured tissue-isolated mast cells had not been reported. METHODS: Human mature mast cells were isolated and purified from normal skin tissue from different donors...
February 1, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29408481/mir-7-5p-functions-as-a-tumor-suppressor-by-targeting-sox18-in-pancreatic-ductal-adenocarcinoma
#18
Weihua Zhu, Yazhou Wang, Dafang Zhang, Xin Yu, Xisheng Leng
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Recently, many kinds of microRNAs (miRNAs) have been found to play a significant role in development of PDAC. However, there is no investigation about expression and function of miR-7-5p in PDAC. In this study, we found that miR-7-5p was down-regulated in PDAC tissues and its low expression level indicated a poor survival rate for PDAC patients. By bioinformatic analysis, we found that miR-7-5p targeted SOX18, and there was a negative correlation between them in PDAC tissues...
February 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29403488/absence-of-tumor-necrosis-factor-supports-alternative-activation-of-macrophages-in-the-liver-after-infection-with-leishmania-major
#19
Shanshan Hu, Cameron Marshall, Jocelyn Darby, Wei Wei, Alan Bruce Lyons, Heinrich Körner
The absence of tumor necrosis factor (TNF) causes lethal infection by Leishmania major in normally resistant C57BL/6J (B6.WT) mice. The underlying pathogenic mechanism of this fatal disease has so far remained elusive. We found that B6.WT mice deficient for the tnf gene (B6.TNF-/-) displayed not only a non-healing cutaneous lesion but also a serious infection of the liver upon L. major inoculation. Infected B6.TNF-/- mice developed an enlarged liver that showed increased inflammation. Furthermore, we detected an accumulating monocyte-derived macrophage population (CD45+F4/80+CD11bhiLy6Clow) that displayed a M2 macrophage phenotype with high expression of CD206, arginase-1, and IL-6, supporting the notion that IL-6 could be involved in M2 differentiation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29389248/the-role-of-gp130-in-basal-and-exercise-trained-skeletal-muscle-mitochondrial-quality-control
#20
Dennis K Fix, Justin P Hardee, Song Gao, Brandon N VanderVeen, Kandy T Velazquez, James A Carson
The IL-6 cytokine family activates intracellular signaling pathways through glycoprotein 130 (gp130), and this signaling has established regulatory roles in muscle glucose metabolism and proteostasis. Although the IL-6 family has been implicated as myokines regulating the muscle's metabolic response to exercise, gp130's role in mitochondrial quality control involving fission, fusion, mitophagy and biogenesis is not well understood. Therefore, we examined gp130's role in basal and exercise-trained muscle mitochondrial quality control...
February 1, 2018: Journal of Applied Physiology
keyword
keyword
117585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"