keyword
MENU ▼
Read by QxMD icon Read
search

Gp130

keyword
https://www.readbyqxmd.com/read/28160627/interleukin-11-driven-gastric-tumourigenesis-is-independent-of-trans-signalling
#1
Jesse J Balic, Christoph Garbers, Stefan Rose-John, Liang Yu, Brendan J Jenkins
Deregulated gp130-dependent STAT3 signalling by the pleiotropic cytokine interleukin (IL)-11 has been implicated in the pathogenesis of gastric cancer (GC), the third most common cancer worldwide. While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved to generate a soluble form (sIL-11R) which can elicit trans-signalling. Since the role of IL-11 trans-signalling in disease pathogenesis is unknown, here we have employed the IL-11-driven gp130(F/F) spontaneous model of GC to determine whether IL-11 trans-signalling promotes gastric tumourigenesis...
February 1, 2017: Cytokine
https://www.readbyqxmd.com/read/28159554/trans-signaling-of-interleukin-6-il-6-is-mediated-by-the-soluble-il-6-receptor-but-not-by-soluble-cd5
#2
Samadhi Aparicio-Siegmund, Malte Deseke, Annett Lickert, Christoph Garbers
IL-6 exerts its pleiotropic activities on its target cells via the IL-6 alpha-receptor (IL-6R), which is expressed on a limited number of cell types. IL-6 can further signal via soluble forms of its receptor (sIL-6R), a process that has been termed trans-signaling. Recently, CD5 was described as an alternative alpha-receptor for IL-6 on B cells leading to the phosphorylation of the transcription factor STAT3 via the signal-transducing β-receptor gp130 in a Jak2-dependent manner. In this study, we sought to investigate whether IL-6 was also able to signal via soluble CD5 (sCD5) analogous to IL-6 trans-signaling...
January 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28130546/yap-il-6st-autoregulatory-loop-activated-on-apc-loss-controls-colonic-tumorigenesis
#3
Koji Taniguchi, Toshiro Moroishi, Petrus R de Jong, Michal Krawczyk, Britta Moyo Grebbin, Huiyan Luo, Rui-Hua Xu, Nicole Golob-Schwarzl, Caroline Schweiger, Kepeng Wang, Giuseppe Di Caro, Ying Feng, Eric R Fearon, Eyal Raz, Lukas Kenner, Henner F Farin, Kun-Liang Guan, Johannes Haybaeck, Christian Datz, Kang Zhang, Michael Karin
Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating mutations rarely occur in human colorectal cancer (CRC). We found that APC loss also results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating Src family kinases (SFKs), YAP, and STAT3, which are simultaneously up-regulated in the majority of human CRC. Although, initial YAP activation, which stimulates IL6ST gene transcription, may be caused by reduced serine phosphorylation, sustained YAP activation depends on tyrosine phosphorylation by SFKs, whose inhibition, along with STAT3-activating JAK kinases, causes regression of established colorectal tumors...
January 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28122728/absence-of-suppressor-of-cytokine-signaling-2-turns-cardiomyocytes-unresponsive-to-lif-dependent-increase-in-ca2-levels
#4
Cibele Rocha-Resende, Itamar Couto Guedes de Jesus, Danilo Roman-Campos, Artur S Miranda, Fabiana Alves, Rodrigo Ribeiro Resende, Jader Dos Santos Cruz, Fabiana Simão Machado, Silvia Guatimosim
Little is known regarding the role of the Suppressor of Cytokine Signaling (SOCS) in the control of cytokine signaling in cardiomyocytes. We investigated the consequences of SOCS2 ablation for Leukemia Inhibitory Factor (LIF)-induced enhancement of intracellular Ca(2+) ([Ca(2+)]i) transient by performing experiments with cardiomyocytes from SOCS2-knockout (ko) mice. Similar levels of SOCS3 transcripts were seen in cardiomyocytes from wild-type and SOCS2-ko, while SOCS1 mRNA was reduced in SOCS2-ko. Immunoprecipitation experiments showed increased SOCS3 association with gp130 receptor in SOCS2-ko myocytes...
January 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28122243/opposing-roles-of-acetylation-and-phosphorylation-in-lifr-dependent-self-renewal-growth-signaling-in-mouse-embryonic-stem-cells
#5
Xiong-Jun Wang, Yunbo Qiao, Minzhe M Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Ming-Dian Tan, Chao Huang, Jinsong Li, Ting C Zhao, Zhaoyuan Hou, Naihe Jing, Y Eugene Chin
LIF promotes self-renewal of mouse embryonic stem cells (mESCs), and in its absence, the cells differentiate. LIF binds to the LIF receptor (LIFR) and activates the JAK-STAT3 pathway, but it remains unknown how the receptor complex triggers differentiation or self-renewal. Here, we report that the LIFR cytoplasmic domain contains a self-renewal domain within the juxtamembrane region and a differentiation domain within the C-terminal region. The differentiation domain contains four SPXX repeats that are phosphorylated by MAPK to restrict STAT3 activation; the self-renewal domain is characterized by a 3K motif that is acetylated by p300...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28117780/sorla-and-clc-clf-1-dependent-downregulation-of-cntfr%C3%AE-as-demonstrated-by-western-blotting-inhibition-of-lysosomal-enzymes-and-immunocytochemistry
#6
Jakob V Larsen, Claus M Petersen
The heterodimeric cytokine Cardiotrophin-like Cytokine:Cytokine-like Factor-1 (CLC:CLF-1) targets the glycosylphosphatidylinositol (GPI)-anchored CNTFRα to form a trimeric complex that subsequently recruits glycoprotein 130/Leukemia Inhibitory Factor Receptor-β (gp130/LIFRβ) for signaling. Both CLC and CNTFRα are necessary for signaling but so far CLF-1 has only been known as a putative facilitator of CLC secretion. However, it has recently been shown that CLF-1 contains three binding sites: one for CLC; one for CNTFRα (that may promote assembly of the trimeric complex); and one for the endocytic receptor sorLA...
January 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28117653/innate-immune-cytokines-fibroblast-phenotypes-and-regulation-of-extracellular-matrix-in-lung
#7
Carl D Richards
Chronic inflammation can be caused by adaptive immune responses in autoimmune and allergic conditions, driven by a T lymphocyte subset balance (TH1, TH2, Th17, Th22, and/or Treg) and skewed cellular profiles in an antigen-specific manner. However, several chronic inflammatory diseases have no clearly defined adaptive immune mechanisms that drive chronicity. These conditions include those that affect the lung such as nonatopic asthma or idiopathic pulmonary fibrosis comprising significant health problems. The remodeling of extracellular matrix (ECM) causes organ dysfunction, and it is largely generated by fibroblasts as the major cell controlling net ECM...
February 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28115285/luhong-formula-inhibits-myocardial-fibrosis-in-a-paracrine-manner-by-activating-the-gp130-jak2-stat3-pathway-in-cardiomyocytes
#8
Huiyan Qu, Yong Wang, Yingjie Wang, Tao Yang, Zhou Feng, Yang Qu, Hua Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Luhong formula (LHF)-a traditional Chinese medicine containing Cervus nippon Temminck,Carthamus tinctorius L., Cinnamomum cassia Presl,Codonopisis pilosula( Franch.) Nannf., Astragalus membranaceus ( Fisch.) Bge. var. mongholicus ( Bge.) Hsiao, Lepidium apetalum Willd-is used in the treatment of heart failure. AIM OF THE STUDY: To investigate the antifibrotic efficacy of LHF in a myocardial infarction-induced rat model of heart failure and to determine its mechanism of action...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28102193/tumour-derived-interleukin-35-promotes-pancreatic-ductal-adenocarcinoma-cell-extravasation-and-metastasis-by-inducing-icam1-expression
#9
Chongbiao Huang, Na Li, Zengxun Li, Antao Chang, Yanan Chen, Tiansuo Zhao, Yang Li, Xiuchao Wang, Wei Zhang, Zhimin Wang, Lin Luo, Jingjing Shi, Shengyu Yang, He Ren, Jihui Hao
Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBV-induced gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly produced by regulatory T cells. However, the role of IL-35 in cancer metastasis and progression is not well understood. Here we demonstrate that IL-35 is overexpressed in human pancreatic ductal adenocarcinoma (PDAC) tissues, and that IL-35 overexpression is associated with poor prognosis in PDAC patients. IL-35 has critical roles in PDAC cell extravasation and metastasis by facilitating the adhesion to endothelial cells and transendothelial extravasation...
January 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28060380/neutralizing-gp130-interferes-with-endothelial-mediated-effects-on-glioblastoma-stem-like-cells
#10
Kathryn A Jacobs, Elizabeth Harford-Wright, Julie Gavard
No abstract text is available yet for this article.
February 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28049968/polyacrylic-resins-regulate-transcriptional-control-of-interleukin-6-gp80-and-gp130-genes-in-human-gingival-fibroblasts
#11
Bruna Borelli, Fernando Zarone, Virginia Rivieccio, Francesco Riccitiello, Michele Simeone, Roberto Sorrentino, Sandro Rengo, Gianrico Spagnuolo, Alfredo Procino
Studies have failed to identify the molecular mechanisms that regulate the genotoxic and cytotoxic effects of methacrylate resins, which are important in the biocompatibility of dental materials. Interleukin (IL)-6 has a crucial role in the control of acute-phase protein response during inflammation. In humans, the synthesis and release of two major acute-phase proteins, C-reactive protein and serum amyloid A, are regulated by IL-6. This study focused on IL-6 and activation of its receptors gp80 and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet Kit, Unifast, and Duralay on control of inflammation...
December 28, 2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28027874/deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-reverses-the-gene-expression-of-cytokines-and-their-receptors-as-well-as-neuronal-degeneration-in-epileptic-rats
#12
Ying-Chuan Chen, Guan-Yu Zhu, Xiu Wang, Lin Shi, Yin Jiang, Xin Zhang, Jian-Guo Zhang
BACKGROUND: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is effective in seizure control. However, the mechanisms remain unclear. METHODS: Sixty-four rats were randomly assigned to the control group, the kainic acid (KA) group, the sham-DBS group and the DBS group. Video-electroencephalogram (EEG) was used to monitor seizures. Quantitative real time PCR (qPCR) was applied for detecting interleukin-1 beta (IL-1β), IL-1 receptor (IL-1R), IL-6, IL-6 receptor (IL-6R), gp130, tumor necrosis factor-alpha (TNF-α), TNF-receptor 1 (TNF-R1) and TNF-receptor 2 (TNF-R2) expression 12 hours after the establishment of an epileptic model...
December 24, 2016: Brain Research
https://www.readbyqxmd.com/read/28027695/inhibitory-mechanism-of-the-outer-membrane-growth-of-chronic-subdural-hematomas
#13
Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Masahiro Aoyama, Kenichiro Iwami, Mikinobu Takeuchi, Takeya Watabe, Masakazu Takayasu
We previously demonstrated that the inflammatory cytokine interleukin-6 (IL-6) activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway in fibroblasts within the outer membranes of chronic subdural hematomas (CSDHs), and the activation of this pathway may induce CSDH outer membrane growth. The inhibitory system for this signal transduction pathway is unknown. CSDH fluids were obtained from ten patients during trepanation surgery as the case group, and CSF samples were obtained from seven patients suffering from subarachnoid hemorrhage (SAH) on day 1 as the control group...
December 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28004013/aberrant-expression-of-interleukin-6-and-its-receptor-in-fallopian-tubes-bearing-an-ectopic-pregnancy-with-and-without-tubal-cytomegalovirus-infection
#14
Ahmed Mohamed Ashshi
Cytomegalovirus (CMV) has recently been suggested as a potential risk factor for the development of ectopic pregnancy (EP) following upper genital tract infection in women. However, little is known about its associated underlying pathogenic mechanisms. This was a prospective case-control study that measured the prevalence of CMV infection in Fallopian tubes (FT) bearing an EP and its effects on the tubal expression of interleukin (IL)-6 and its signaling molecules, which are known to play significant roles in the immune response against CMV infection as well as embryo implantation...
December 2016: Virusdisease
https://www.readbyqxmd.com/read/27957549/%C3%AE-arrestin-2-attenuates-cardiac-dysfunction-in-polymicrobial-sepsis-through-gp130-and-p38
#15
Hui Yan, Hui Li, James Denney, Christopher Daniels, Krishna Singh, Balvin Chua, Charles Stuart, Yi Caudle, Ronald Hamdy, Gene LeSage, Deling Yin
Sepsis is an exaggerated systemic inflammatory response to persistent bacteria infection with high morbidity and mortality rate clinically. β-arrestin 2 modulates cell survival and cell death in different systems. However, the effect of β-arrestin 2 on sepsis-induced cardiac dysfunction is not yet known. Here, we show that β-arrestin 2 overexpression significantly enhances animal survival following cecal ligation and puncture (CLP)-induced sepsis. Importantly, overexpression of β-arrestin 2 in mice prevents CLP-induced cardiac dysfunction...
September 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/27957415/the-role-of-local-il6-jak2-stat3-signaling-in-high-glucose-induced-podocyte-hypertrophy
#16
Hyung Ah Jo, Joo-Young Kim, Seung Hee Yang, Seung Seok Han, Kwon Wook Joo, Yon Su Kim, Dong Ki Kim
BACKGROUND: Interleukin-6 (IL6) is an important regulator of cellular hypertrophy through the gp130/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway. We tested the hypothesis that IL6 and its downstream gp130/JAK2/STAT3 pathway participated in high glucose (HG)-induced podocyte hypertrophy. METHODS: IL6 levels in the media and lysates of podocytes were measured by enzyme-linked immunosorbent assay. Western blots were performed to determine the protein expression levels of gp130/JAK2/STAT3 among podocytes cultured with normal glucose (NG), NG + mannitol, NG + recombinant IL6, HG, and HG + IL6-neutralizing antibodies (IL6NAb)...
December 2016: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/27939431/crosstalk-between-different-family-members-il27-recapitulates-ifn%C3%AE-responses-in-hcc-cells-but-is-inhibited-by-il6-type-cytokines
#17
Catherine Rolvering, Andreas D Zimmer, Ines Kozar, Heike M Hermanns, Elisabeth Letellier, Laurent Vallar, Petr V Nazarov, Nathalie Nicot, Aurélien Ginolhac, Serge Haan, Iris Behrmann, Claude Haan
Interleukin-27 (IL27) is a type-I-cytokine of the IL6/IL12 family predominantly secreted by activated macrophages and dendritic cells. In the liver, IL27 expression was observed to be upregulated in patients with hepatitis B, and sera of hepatocellular carcinoma (HCC) patients contain significantly elevated levels of IL27 compared to healthy controls or patients with hepatitis and/or liver cirrhosis. In this study, we show that IL27 induces STAT1 and STAT3 phosphorylation in 5 HCC lines and 3 different types of non-transformed liver cells...
December 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27917904/glycoprotein-130-is-associated-with-adverse-postoperative-clinical-outcomes-of-patients-with-late-stage-non-metastatic-gastric-cancer
#18
Yifan Cao, Heng Zhang, Hao Liu, Chao Lin, Ruochen Li, Songyang Wu, Hongyong He, He Li, Jiejie Xu
The interaction of glycoprotein 130 (gp130) with the cytokines of Interleukin-6 (IL-6) family has proved to play a crucial part in several cancers. Our current study is designed to discover the clinical prognostic significance of gp130 in non-metastatic gastric cancer. We examined intratumoral gp130 expression in retrospectively enrolled 370 gastric cancer patients who underwent radical gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital of Fudan University during 2007 and 2008 by immunohistochemical staining...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893707/blockade-of-the-il-6-trans-signalling-stat3-axis-suppresses-cachexia-in-kras-induced-lung-adenocarcinoma
#19
A Miller, L McLeod, S Alhayyani, A Szczepny, D N Watkins, W Chen, P Enriori, W Ferlin, S Ruwanpura, B J Jenkins
Lung cancer is the leading cause of cancer death worldwide, and is frequently associated with the devastating paraneoplastic syndrome of cachexia. The potent immunomodulatory cytokine interleukin (IL)-6 has been linked with the development of lung cancer as well as cachexia; however, the mechanisms by which IL-6 promotes muscle wasting in lung cancer cachexia are ill-defined. In this study, we report that the gp130(F/F) knock-in mouse model displaying hyperactivation of the latent transcription factor STAT3 via the common IL-6 cytokine family signalling receptor, gp130, develops cachexia during Kras-driven lung carcinogenesis...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27886185/hyper-il-6-a-potent-and-efficacious-stimulator-of-rgc-regeneration
#20
D Fischer
Mature retinal ganglion cells (RGCs) normally fail to regenerate injured axons and die soon after optic nerve injury. Research over the last two decades has demonstrated that application of IL-6-like cytokines or activation of respective downstream signaling pathways promote neuroprotection and optic nerve regeneration. However, the overall beneficial effects of natural cytokines remain usually rather moderate, possibly due to intrinsic signaling pathway inhibitors, such as PTEN or SOCS3, or a limited expression of specific cytokine receptors in RGCs...
February 2017: Eye
keyword
keyword
117585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"