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https://www.readbyqxmd.com/read/27904405/evaluation-of-prebiotic-effects-of-high-purity-galactooligosaccharides-in-vitro-and-in-vivo
#1
Ki Bae Hong, Jae Hwan Kim, Hyuk Kon Kwon, Sung Hee Han, Yooheon Park, Hyung Joo Suh
Galactooligosaccharides (GOS) are an important class of dietary prebiotics that exert beneficial effects on intestinal microbiota and gut barrier function. In this study, high-purity GOS (HP-GOS) were investigated in vitro and in vivo and confirmed as prebiotic ingredients in rat diet. HP-GOS were successfully produced using a two-step process, enzymatic hydrolysis and fermentation by yeast. They were found to serve as a good substrate and carbon source for supporting the growth of probiotic bacteria more effectively than other commercial GOS...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904010/application-of-enteric-seamless-capsules-containing-bifidobacterium-longum-to-functional-foods
#2
Mamiko Kohno, Yukimasa Tanaka-Azuma, Ryosei Kamaguchi, Daisuke Tagawa
No abstract text is available yet for this article.
2016: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/27891089/effect-of-probiotic-supplementation-on-cognitive-function-and-metabolic-status-in-alzheimer-s-disease-a-randomized-double-blind-and-controlled-trial
#3
Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami
: Alzheimer's disease (AD) is associated with severe cognitive impairments as well as some metabolic defects. Scant studies in animal models indicate a link between probiotics and cognitive function. This randomized, double-blind, and controlled clinical trial was conducted among 60 AD patients to assess the effects of probiotic supplementation on cognitive function and metabolic status. The patients were randomly divided into two groups (n = 30 in each group) treating with either milk (control group) or a mixture of probiotics (probiotic group)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27886651/foam-mat-freeze-drying-of-bifidobacterium-longum-ro175-viability-and-refrigerated-storage-stability
#4
Danilo Izquierdo-López, Jacques Goulet, Cristina Ratti
Foaming as a pretreatment was used prior to freeze-drying of Bifidobacterium longum RO175 to investigate the potential acceleration of the drying rate and increase in microorganism viability after the process. A study on storage of foamed and nonfoamed freeze-dried products at 4 °C completed this study. B. longum RO175 in foamed medium could be freeze-dried in 1/7 to 1/4 of the time required for nonfoamed suspensions. In addition, foamed suspensions presented higher viability immediately after freeze-drying (13...
November 25, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27886064/probiotic-supplements-beneficially-affect-tryptophan-kynurenine-metabolism-and-reduce-the-incidence-of-upper-respiratory-tract-infections-in-trained-athletes-a-randomized-double-blinded-placebo-controlled-trial
#5
Barbara Strasser, Daniela Geiger, Markus Schauer, Johanna M Gostner, Hannes Gatterer, Martin Burtscher, Dietmar Fuchs
BACKGROUND: Prolonged intense exercise has been associated with transient suppression of immune function and an increased risk of infections. In this context, the catabolism of amino acid tryptophan via kynurenine may play an important role. The present study examined the effect of a probiotic supplement on the incidence of upper respiratory tract infections (URTI) and the metabolism of aromatic amino acids after exhaustive aerobic exercise in trained athletes during three months of winter training...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27884128/a-randomised-controlled-demonstration-trial-of-multifaceted-nutritional-intervention-and-or-probiotics-the-healthy-mums-and-babies-humba-trial
#6
Karaponi Okesene-Gafa, Minglan Li, Rennae S Taylor, John M D Thompson, Caroline A Crowther, Christopher J D McKinlay, Lesley M E McCowan
BACKGROUND: Maternal obesity is associated with adverse pregnancy outcomes and has lifelong negative implications for offspring health. The Institute of Medicine recommends limited gestational weight gain (GWG) in obese women for optimal maternal and infant outcomes. However, there is a gap regarding an effective and sustainable intervention strategy to achieve this goal. The aim of the healthy mums and babies (HUMBA) demonstration trial is to assess whether a multifaceted nutritional intervention and/or an oral probiotic treatment in obese pregnant women can reduce excessive GWG and optimise pregnancy outcomes...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27883285/time-and-strain-specific-downregulation-of-intestinal-epas1-via-mir-148a-by-bifidobacterium-bifidum
#7
Amel Taibi, Natasha Singh, Jianmin Chen, Stefania Arioli, Simone Guglielmetti, Elena M Comelli
SCOPE: Bifidobacteria play a role in intestinal homeostasis but molecular mechanisms remain under-investigated. The aim of this study was to assess if probiotic Bifidobacterium strains alter expression of intestinal microRNA and downstream target gene response. METHODS AND RESULTS: The expression of miR-148a and its validated target EPAS1 (endothelial PAS domain protein 1) was analyzed in Caco-2 cells and mice cecum in response to Bifidobacterium bifidum MIMBb75, B...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27882741/bacteremia-induced-by-bifidobacterium-breve-in-a-newborn-with-cloacal-exstrophy
#8
Shinichi Sato, Toshihiko Uchida, Shota Kuwana, Kazuto Sasaki, Tatsuya Watanabe, Junko Saito, Takahiro Kawaji
Bifidobacterium breve is an effective probiotic agent used in the field of neonatology. Although B. breve has been considered safe, a case of B. breve bacteremia has been reported. The pathogenic mechanism underlying the bacteremia is unknown. Herein, we report a second case of B. breve bacteremia that developed in a neonate with multiple abdominal organ anomalies. Following surgical repair immediately after birth, B. breve treatment was started. After 1 week, the infant developed B. breve bacteremia following the onset of adhesive ileus...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27876765/pre-and-post-weaning-diet-alters-the-faecal-metagenome-in-the-cat-with-differences-vitamin-and-carbohydrate-metabolism-gene-abundances
#9
Wayne Young, Christina D Moon, David G Thomas, Nick J Cave, Emma N Bermingham
Dietary format, and its role in pet nutrition, is of interest to pet food manufacturers and pet owners alike. The aim of the present study was to investigate the effects of pre- and post-weaning diets (kibbled or canned) on the composition and function of faecal microbiota in the domestic cat by shotgun metagenomic sequencing and gene taxonomic and functional assignment using MG-RAST. Post-weaning diet had a dramatic effect on community composition; 147 of the 195 bacterial species identified had significantly different mean relative abundances between kittens fed kibbled and canned diets...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876597/role-of-synbiotics-in-polysaccharide-assisted-colon-targeted-microspheres-of-mesalamine-for-the-treatment-of-ulcerative-colitis
#10
Rupinderjeet Kaur, Monica Gulati, Sachin Kumar Singh
The present study explains the effect of concomitant administration of synbiotics with the polysaccharide based colon targeted delivery system. As the gut microflora get deranged on administration of mesalamine, drug release from such delivery systems is expected to be jeopardised because the release trigger is dependent solely on the colonic microbiota. To overcome this limitation, mesalamine was formulated as microspheres with guar gum and xanthan gum (prebiotics). These were combined with probiotics containing Lactobacillus acidophilus, L...
November 19, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27874107/the-effect-of-oral-consumption-of-probiotics-in-prevention-of-heart-injury-in-a-rat-myocardial-infarction-model-a-histopathological-hemodynamic-and-biochemical-evaluation
#11
Jafar Sadeghzadeh, Abedin Vakili, Hamid Reza Sameni, Mahdi Shadnoush, Ahmad-Reza Bandegi, Mahdi Zahedi Khorasani
BACKGROUND: Despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. METHODS: Four viable probiotics bacterial strains, including Bifidobacterium breve, Lactobacillus casei, Lactobacillus bulgaricus and Lactobacillus acidophilus, at the concentrations of 2×106 colony-forming units/ml were orally administered to the rats daily for 14 days before the induction of infarct-like myocardial injury using isoproterenol...
November 22, 2016: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/27874076/oligofructose-as-an-adjunct-in-treatment-of-diabetes-in-nod-mice
#12
Clement Chan, Colin M Hyslop, Vipul Shrivastava, Andrea Ochoa, Raylene A Reimer, Carol Huang
In type 1 diabetes, restoration of normoglycemia can be achieved if the autoimmune attack on beta cells ceases and insulin requirement is met by the residual beta cells. We hypothesize that an adjunctive therapy that reduces insulin demand by increasing insulin sensitivity will improve the efficacy of an immunotherapy in reversing diabetes. We tested the gut microbiota-modulating prebiotic, oligofructose (OFS), as the adjunctive therapy. We treated non-obese diabetic mice with an immunotherapy, monoclonal anti-CD3 antibody (aCD3), with or without concurrent dietary supplement of OFS...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869661/an-exploratory-investigation-of-endotoxin-levels-in-novice-long-distance-triathletes-and-the-effects-of-a-multi-strain-probiotic-prebiotic-antioxidant-intervention
#13
Justin D Roberts, Craig A Suckling, Georgia Y Peedle, Joseph A Murphy, Tony G Dawkins, Michael G Roberts
Gastrointestinal (GI) ischemia during exercise is associated with luminal permeability and increased systemic lipopolysaccharides (LPS). This study aimed to assess the impact of a multistrain pro/prebiotic/antioxidant intervention on endotoxin unit levels and GI permeability in recreational athletes. Thirty healthy participants (25 males, 5 females) were randomly assigned either a multistrain pro/prebiotic/antioxidant (LAB⁴ANTI; 30 billion CFU·day(-1) containing 10 billion CFU·day(-1)Lactobacillus acidophilus CUL-60 (NCIMB 30157), 10 billion CFU·day(-1)Lactobacillus acidophillus CUL-21 (NCIMB 30156), 9...
November 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27867803/effect-of-bifidobacterium-animalis-ssp-lactis-gcl2505-on-visceral-fat-accumulation-in-healthy-japanese-adults-a-randomized-controlled-trial
#14
Shota Takahashi, Daisuke Anzawa, Kazuyo Takami, Akihiro Ishizuka, Takashi Mawatari, Kohei Kamikado, Haruhi Sugimura, Tomohiko Nishijima
Bifidobacterium animalis ssp. lactis GCL2505 (B. lactis GCL2505) is able to survive passage through the intestine and then proliferate, leading to an increase in the amount of gut bifidobacteria. In the present study, we evaluated the impact of B. lactis GCL2505 on abdominal visceral fat storage in overweight and mildly obese Japanese adults. This clinical study was a double-blind, randomized, placebo-controlled, parallel-group comparative trial performed for 12 weeks. Healthy Japanese subjects (N=137) with body mass indices ranging from 23 to 30 kg/m(2) consumed either fermented milk containing B...
2016: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/27866040/in-vitro-fermentation-of-different-fructo-oligosaccharides-by-bifidobacterium-strains-for-the-selection-of-synbiotic-combinations
#15
Lorena Valdés-Varela, Patricia Ruas-Madiedo, Miguel Gueimonde
The use of selected probiotics, prebiotics and/or synbiotics, constitute an interesting dietary strategy for intestinal microbiota modulation in case of dysbiosis. Species of the genus Bifidobacterium are among the most currently used probiotics for human consumption since they have shown beneficial effects in the prevention and treatment of some disorders. Bifidobacteria are saccharolytic microorganisms, but their ability to use different carbohydrates varies among strains. In this study, we investigate the utilization of three prebiotic substrates (two different short-chain fructo-oligosaccharides [scFOS] and inulin) by strains of Bifidobacterium, in order to determine the synbiotic potential of the different probiotic/prebiotic combinations...
November 12, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27864179/prevalence-of-antibiotic-resistance-genes-among-human-gut-derived-bifidobacteria
#16
Sabrina Duranti, Gabriele Andrea Lugli, Leonardo Mancabelli, Francesca Turroni, Christian Milani, Marta Mangifesta, Chiara Ferrario, Rosaria Anzalone, Alice Viappiani, Douwe van Sinderen, Marco Ventura
: The microbiota of the human gastrointestinal tract (GIT) may regularly be exposed to antibiotics, which are used to prevent and treat infectious diseases caused by bacteria and fungi. Bacterial communities of the gut retain a reservoir of antibiotic resistance (AR) genes, and antibiotic therapy thus positively selects for those microorganisms that harbor such genetic features, causing microbiota modulation. During the first months following birth, bifidobacteria represent one of the most dominant components of the human gut microbiota, though little is known about their AR gene complement (or resistome)...
November 18, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27861621/an-alteration-in-the-cecal-microbiota-composition-by-feeding-of-1-kestose-results-in-a-marked-increase-in-the-cecal-butyrate-content-in-rats
#17
Takumi Tochio, Yasuyuki Kitaura, Saki Nakamura, Chie Sugawa, Motoki Takahashi, Akihito Endo, Yoshiharu Shimomura
Functional food ingredients, including prebiotics, have been ardently developed for improving the intestinal environment. Fructooligosaccarides (FOS), including fructans, are the well researched and commercialized prebiotics. However, to our knowledge, few studies have been conducted on the physiological effects of each component of FOS as prebiotics. 1-Kestose, a component of FOS, is composed of one glucose and two fructose molecules, and is considered as a key prebiotic component in short-chain FOS. In the present study, we examined the effects of dietary 1-kestose using 0...
2016: PloS One
https://www.readbyqxmd.com/read/27860030/imbalance-of-bacteriome-profiles-within-the-finnish-diabetes-prediction-and-prevention-study-parallel-use-of-16s-profiling-and-virome-sequencing-in-stool-samples-from-children-with-islet-autoimmunity-and-matched-controls
#18
Ondrej Cinek, Lenka Kramna, Jake Lin, Sami Oikarinen, Katerina Kolarova, Jorma Ilonen, Olli Simell, Riitta Veijola, Reija Autio, Heikki Hyöty
BACKGROUND: We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS: Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimmunity (median age 17.4 months) followed by type 1 diabetes, and 18 tightly matched controls from the Finnish Diabetes Prediction and Prevention (DIPP) cohort...
November 17, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27857709/genotyping-by-pcr-and-high-throughput-sequencing-of-commercial-probiotic-products-reveals-composition-biases
#19
Wesley Morovic, Ashley A Hibberd, Bryan Zabel, Rodolphe Barrangou, Buffy Stahl
Recent advances in microbiome research have brought renewed focus on beneficial bacteria, many of which are available in food and dietary supplements. Although probiotics have historically been defined as microorganisms that convey health benefits when ingested in sufficient viable amounts, this description now includes the stipulation "well defined strains," encompassing definitive taxonomy for consumer consideration and regulatory oversight. Here, we evaluated 52 commercial dietary supplements covering a range of labeled species using plate counting and targeted genotyping...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27852545/effects-of-zinc-or-synbiotic-on-the-duration-of-diarrhea-in-children-with-acute-infectious-diarrhea
#20
Ahmet Sami Yazar, Şirin Güven, Ener Çağrı Dinleyici
BACKGROUND/AIMS: Probiotic effects on acute infectious diarrhea are strain(s) specific, and all formulations should be evaluated by clinical trials. We aimed to evaluate the effect of a synbiotic preparation on the duration of diarrhea in children compared to a zinc suspension. MATERIALS AND METHODS: We conducted a single-center, randomized, and controlled clinical trial in children with acute infectious diarrhea. The first group received a synbiotic preparation containing Lactobacillus casei, L...
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
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