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https://www.readbyqxmd.com/read/27855513/recent-developments-in-circulating-biomarkers-in-parkinson-s-disease-the-potential-use-of-mirnas-in-a-clinical-setting
#1
Marcia Cristina Teixeira Dos Santos, Rosie Bell, Andre Nogueira da Costa
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 5% of the elderly population. PD diagnosis is still based on the identification of neuromotor symptoms although nonmotor manifestations emerge years prior to diagnosis. The discovery of biomarkers at the earliest stages of PD is of extreme interest. miRNAs have been considered potential biomarkers for neurodegenerative diseases, but only a limited number have been found to be PD related. This review focuses on the current findings in the field of circulating miRNAs in PD and the challenges surrounding clinical utility and validation...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27847348/characterization-of-infant-mu-rhythm-immediately-before-crawling-a-high-resolution-eeg-study
#2
Ran Xiao, Xiao Qi, Alejandro Patino, Andrew H Fagg, Thubi H A Kolobe, David P Miller, Lei Ding
Crawling is an important milestone in infant motor development. However, infants with developmental motor disorders can exhibit delays, or even miss, in the acquisition of crawling skill. And little information is available from the neurodevelopmental domain about the changes in brain function with intervention. The mu rhythm can potentially play a substantial role in understanding human motor development at early ages in infants, as it has in adults. Studies about the mu rhythm in infants were in coarse temporal resolution with longitudinal samples taken months or years apart...
November 12, 2016: NeuroImage
https://www.readbyqxmd.com/read/27742862/hypertonia-assessment-tool-reliability-and-validity-in-children-with-neuromotor-disorders
#3
Petra Marsico, Victoria Frontzek-Weps, Julia Balzer, Hubertus J A van Hedel
The Hypertonia Assessment Tool is a 7-item instrument that discriminates spasticity, dystonia, and rigidity on 3 levels: item scores, subtype, and hypertonia diagnosis for each extremity. We quantified the inter- and intrarater reliability using Kappa statistics, Gwet's first-order agreement coefficient (both with 95% confidence interval), and percentage agreement for all levels. For validity, we compared the Hypertonia Assessment Tool subtype with the clinical diagnosis provided by the physicians. Two physiotherapists tested 45 children with neuromotor disorders...
October 14, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27701907/speech-and-nonspeech-what-are-we-talking-about
#4
Edwin Maas
Understanding of the behavioural, cognitive and neural underpinnings of speech production is of interest theoretically, and is important for understanding disorders of speech production and how to assess and treat such disorders in the clinic. This paper addresses two claims about the neuromotor control of speech production: (1) speech is subserved by a distinct, specialised motor control system and (2) speech is holistic and cannot be decomposed into smaller primitives. Both claims have gained traction in recent literature, and are central to a task-dependent model of speech motor control...
October 5, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27683483/clinical-characterization-genetics-and-long-term-follow-up-of-a-large-cohort-of-patients-with-agenesis-of-the-corpus-callosum
#5
Romina Romaniello, Susan Marelli, Roberto Giorda, Maria F Bedeschi, Maria C Bonaglia, Filippo Arrigoni, Fabio Triulzi, Maria T Bassi, Renato Borgatti
To gain a better understanding of the clinical and genetic features associated with agenesis of corpus callosum, we enrolled and characterized 162 patients with complete or partial agenesis of corpus callosum. Clinical and genetic protocols allowed us to categorize patients as syndromic subjects, affected by complex extra-brain malformations, and nonsyndromic subjects without any additional anomalies. We observed slight differences in sex ratio (56% males) and agenesis type (52% complete). Syndromic agenesis of corpus callosum subjects were prevalent (69%)...
September 28, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27648849/differences-between-the-activity-of-the-masticatory-muscles-of-adults-with-cerebral-palsy-and-healthy-individuals-while-at-rest-and-in-function
#6
Miriam Yumi Matsui, Lilian Chrystiane Giannasi, Sandra Regina Freitas Batista, Jose Benedito Oliveira Amorim, Claudia S Oliveira, Luis Vicente F Oliveira, Monica Fernandes Gomes
OBJECTIVE: The aim of the present study was to compare the electromyographic activity of masticatory muscles of adult patients with different degrees of oral motor impairment (cerebral palsy) with the electromyographic activity of healthy individuals in a control group. Electromyographic activity was compared when the masticatory muscles were at rest and in motion. DESIGN: Thirty adult patients with cerebral palsy and 30 subjects without neuromotor disorders were enrolled in the present study...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27541087/cerebral-palsy-i
#7
M C Piper
Physical and occupational therapists have long been associated with the care and treatment of children with cerebral palsy. This review paper examines this association in light of current prevalence data and clinical research findings. A variety of epidemiological issues, such as the impact of neonatal intensive care and the risk of preterm birth are considered. Recent evidence suggests that cerebral palsy as a neuromotor disorder is not appearing. Implications of this finding for physical and occupational therapists are discussed...
1983: Physical & Occupational Therapy in Pediatrics
https://www.readbyqxmd.com/read/27468604/-new-opportunities-in-neuro-rehabilitation-robot-mediated-therapy-in-conditons-post-central-nervous-system-impairments
#8
REVIEW
Gábor Fazekas, Ibolya Tavaszi, András Tóth
Decreasing the often-seen multiple disabilities as a consequence of central nervous system impairments requires broadening of the tools of rehabilitation. A promising opportunity for this purpose is the application of physiotherapy robots. The development of such devices goes back a quarter of century. Nowadays several robots are commercially available both for supporting upper and lower limb therapy. The aim is never to replace the therapists, but rather to support and supplement their work. It is worthwhile applying these devices for goal-oriented exercises in high repetition, which one physically fatiguing for the therapist or for the correction of functional movement by various strategies...
March 30, 2016: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/27358225/clinical-effects-of-non-invasive-cerebellar-magnetic-stimulation-treatment-combined-with-neuromotor-rehabilitation-in-traumatic-brain-injury-a-single-case-study
#9
Alex Martino Cinnera, S Bonnì, M Iosa, V Ponzo, A Fusco, Carlo Caltagirone, Giacomo Koch
Multimodal treatments are emerging as effective approaches for motor recovery in traumatic brain injury (TBI). Various evidence has demonstrated that repetitive transcranial magnetic stimulation (rTMS) may improve outcomes in people with motor disorders. Behavioral gains from rTMS protocols may be maximized when brain stimulation is coupled with carefully designed occupational/physical therapy. We present the case of a 25-year-old man with chronic TBI (a bilateral corticosubcortical parieto-occipital lesion) who underwent three weeks of cerebellar intermittent theta burst stimulation (iTBS), a form of rTMS, combined with neurorehabilitation treatment...
April 2016: Functional Neurology
https://www.readbyqxmd.com/read/27290613/children-with-nocturnal-enuresis-have-posture-and-balance-disorders
#10
R Pavione Rodrigues Pereira, S Nascimento Fagundes, A Surry Lebl, L Azevedo Soster, M G Machado, V H Koch, C Tanaka
INTRODUCTION: Integration of the neuromuscular system is required for maintaining balance and adequate voiding function. Children with enuresis have delayed maturation of the motor cortex, with changes in the sensory and motor systems. Along with various alterations, including the genetic, hormonal, behavioral, and sleep disturbances, and neuromotor and sensory deficits associated with nocturnal enuresis (NE) in children and adults, a consistent alteration in the posture of children with NE has been observed in the current practice...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27226610/investigating-the-mechanism-by-which-gain-of-function-mutations-to-the-%C3%AE-1-glycine-receptor-cause-hyperekplexia
#11
Yan Zhang, Anna Bode, Bindi Nguyen, Angelo Keramidas, Joseph W Lynch
Hyperekplexia is a rare human neuromotor disorder caused by mutations that impair the efficacy of glycinergic inhibitory neurotransmission. Loss-of-function mutations in the GLRA1 or GLRB genes, which encode the α1 and β glycine receptor (GlyR) subunits, are the major cause. Paradoxically, gain-of-function GLRA1 mutations also cause hyperekplexia, although the mechanism is unknown. Here we identify two new gain-of-function mutations (I43F and W170S) and characterize these along with known gain-of-function mutations (Q226E, V280M, and R414H) to identify how they cause hyperekplexia...
July 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27222258/clinical-effects-of-non-invasive-cerebellar-magnetic-stimulation-treatment-combined-with-neuromotor-rehabilitation-in-traumatic-brain-injury-a-single-case-study
#12
Alex Martino Cinnera, S Bonnì, M Iosa, V Ponzo, A Fusco, Carlo Caltagirone, Giacomo Koch
Multimodal treatments are emerging as effective approaches for motor recovery in traumatic brain injury (TBI). Various evidence has demonstrated that repetitive transcranial magnetic stimulation (rTMS) may improve outcomes in people with motor disorders. Behavioral gains from rTMS protocols may be maximized when brain stimulation is coupled with carefully designed occupational/physical therapy. We present the case of a 25-year-old man with chronic TBI (a bilateral corticosubcortical parieto-occipital lesion) who underwent three weeks of cerebellar intermittent theta burst stimulation (iTBS), a form of rTMS, combined with neurorehabilitation treatment...
May 25, 2015: Functional Neurology
https://www.readbyqxmd.com/read/27095886/mental-health-problems-in-children-with-neuromotor-disabilities
#13
Benjamin Klein
Mental health in children with neuromotor disorders is part of a dynamic system, including medical and developmental domains, family, school and community. Presentations are often complex and multifactorial, requiring a broad, individualized approach. A narrative overview of mental health symptoms in children with neuromotor disabilities is provided, along with recommendations for their assessment and management using the WHO's International Classification of Functioning framework.
March 2016: Paediatrics & Child Health
https://www.readbyqxmd.com/read/27089297/mindfulness-interventions-in-physical-rehabilitation-a-scoping-review
#14
REVIEW
Mark E Hardison, Shawn C Roll
A scoping review was conducted to describe how mindfulness is used in physical rehabilitation, identify implications for occupational therapy practice, and guide future research on clinical mindfulness interventions. A systematic search of four literature databases produced 1,524 original abstracts, of which 16 articles were included. Although only 3 Level I or II studies were identified, the literature included suggests that mindfulness interventions are helpful for patients with musculoskeletal and chronic pain disorders and demonstrate trends toward outcome improvements for patients with neurocognitive and neuromotor disorders...
May 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/27074125/the-motor-profile-of-preterm-infants-at-11-y-of-age
#15
Sirkku Setänen, Liisa Lehtonen, Riitta Parkkola, Jaakko Matomäki, Leena Haataja
BACKGROUND: Preterm infants are at a higher risk for poor motor outcome than term infants. This study aimed to describe the long-term motor profile in very preterm born children. METHODS: A total of 98 very preterm infants were included. Volumetric brain magnetic resonance imaging (MRI) was performed at term age, and the Movement Assessment Battery for Children-Second Edition (The Movement ABC-2) was employed at 11 y of age. The diagnosis of Developmental Coordination Disorder (DCD) was determined at 11 y of age according to the International Classification of Diseases...
September 2016: Pediatric Research
https://www.readbyqxmd.com/read/27036065/the-importance-of-de-novo-mutations-for-pediatric-neurological-disease-it-is-not-all-in-utero-or-birth-trauma
#16
REVIEW
Robert P Erickson
The advent of next generation sequencing (NGS, which consists of massively parallel sequencing to perform TGS (total genome sequencing) or WES (whole exome sequencing)) has abundantly discovered many causative mutations in patients with pediatric neurological disease. A surprisingly high number of these are de novo mutations which have not been inherited from either parent. For epilepsy, autism spectrum disorders, and neuromotor disorders, including cerebral palsy, initial estimates put the frequency of causative de novo mutations at about 15% and about 10% of these are somatic...
January 2016: Mutation Research. Reviews in Mutation Research
https://www.readbyqxmd.com/read/27008504/preparing-a-neuropediatric-upper-limb-exergame-rehabilitation-system-for-home-use-a-feasibility-study
#17
Corinna N Gerber, Bettina Kunz, Hubertus J A van Hedel
BACKGROUND: Home-based, computer-enhanced therapy of hand and arm function can complement conventional interventions and increase the amount and intensity of training, without interfering too much with family routines. The objective of the present study was to investigate the feasibility and usability of the new portable version of the YouGrabber® system (YouRehab AG, Zurich, Switzerland) in the home setting. METHODS: Fifteen families of children (7 girls, mean age: 11...
March 23, 2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/26916334/age-dependent-neuroinflammation-and-cognitive-decline-in-a-novel-ala152thr-tau-transgenic-mouse-model-of-psp-and-ad
#18
Astrid Sydow, Katja Hochgräfe, Stefanie Könen, Daniela Cadinu, Dorthe Matenia, Olga Petrova, Maria Joseph, Frank Johannes Dennissen, Eva-Maria Mandelkow
INTRODUCTION: Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. In vitro Tau-A152T shows a decreased binding to microtubules and a reduced tendency to form abnormal fibers. RESULTS: To study the effects of this mutation we generated a mouse model expressing human full-length Tau with this mutation (hTau40(AT))...
2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/26913581/discriminant-ability-of-the-infant-neurological-international-battery-infanib-as-a-screening-tool-for-the-neurological-follow-up-of-high-risk-infants-in-colombia
#19
Nathalie Charpak, Ana María de la Hoz, Julieta Villegas, Fabián Gil
AIM: The aim of this study was to assess the discriminative ability of the Infant Neurological International Battery (INFANIB), applied at 3, 6 and 9 months of corrected age (CA), on neurological outcomes at 1 year of CA. METHOD: An observational analytic study was conducted on a cohort of 5857 infants, followed up to 1 year of CA in a Kangaroo Mother Care programme from 1993 to 2010 in Bogotá, Colombia. Infants were included if they had two complete INFANIB results at 3 or 6 or 9 months of CA and at 12 months of CA, including the Griffiths Scale...
May 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26906262/introduction-to-equine-physical-therapy-and-rehabilitation
#20
REVIEW
Catherine M McGowan, Suzanne Cottriall
Physical therapy (physiotherapy, or PT) can be broadly defined as the restoration of movement and function and includes assessment, treatment, and rehabilitation. This review outlines the history, definition, and regulation of PT, followed by the core scientific principles of PT. Because musculoskeletal physiotherapy is the predominant subdiscipline in equine PT, encompassing poor performance, back pain syndromes, other musculoskeletal disorders, and some neuromuscular disorders, the sciences of functional biomechanics, neuromotor control, and the sensorimotor system in the spine, pelvis, and peripheral joints are reviewed...
April 2016: Veterinary Clinics of North America. Equine Practice
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