keyword
https://read.qxmd.com/read/38493473/do-children-with-asymptomatic-ventricular-preexcitation-have-similar-quality-of-life-as-healthy-children
#1
JOURNAL ARTICLE
Emilia Szafran, Michał Bartecki, Anna Bukowska-Posadzy, Artur Baszko, Jarosław Walkowiak, Waldemar Bobkowski
BACKGROUND: To our knowledge, no studies have assessed quality of life (QoL) in asymptomatic children with a preexcitation electrocardiogram pattern. AIM: To evaluate the QoL of children with asymptomatic Wolff-Parkinson-White (WPW) syndrome. METHODS: This study involved QoL assessment of 31 children with asymptomatic preexcitation and 82 healthy children using the WHOQOL-BREF and the Pediatric Arrhythmia Related Score (PARS), a specific questionnaire that we have developed, which is related to patients' feelings and observations concerning arrhythmia...
2024: Kardiologia Polska
https://read.qxmd.com/read/38493418/intrauterine-interventions-options-for-preventing-recurrence-after-hysteroscopic-adhesiolysis-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Ruonan Tang, Wanlin Zhang, Xifeng Xiao, Wenyi Li, Xinxin Chen, Xiaohong Wang
PURPOSE: Recurrence of adhesions after hysteroscopic adhesiolysis is a challenging clinical problem without a unified management approach. Therefore, we conducted a network meta-analysis that considered both direct and indirect comparisons between interventions to identify optimal strategies for preventing recurrence. METHODS: We searched for research trials published up to July 2023 from PubMed, Embase and the Cochrane Database. We selected randomized controlled trials comparing the use of different interventions for the prevention of adhesion recurrence, with no language or regional restrictions...
March 17, 2024: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/38493408/a-novel-mitochondrial-unfolded-protein-response-related-risk-signature-to-predict-prognosis-immunotherapy-and-sorafenib-sensitivity-in-hepatocellular-carcinoma
#3
JOURNAL ARTICLE
Sidi Zhang, Hanyao Guo, Hongyu Wang, Xiaopeng Liu, Meixia Wang, Xiaoyu Liu, Yumei Fan, Ke Tan
Hepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt ) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt -related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases...
March 17, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38493394/contraception-initiation-in-the-emergency-department-adolescent-perspectives
#4
JOURNAL ARTICLE
Tara Ketterer, Erin Sieke, Jungwon Min, Maria Quidgley-Martin, Romina L Barral, Aletha Akers, Amber Adams, Elizabeth Miller, Melissa K Miller, Cynthia Mollen
PURPOSE: The purpose of this study was to identify factors affecting contraceptive intention and behavior among adolescent females in the pediatric Emergency Department. METHODS: We conducted a qualitative interview study nested within a larger prospective cohort study examining adolescent contraceptive counseling for females ages 15-18 years at-risk of unintended pregnancy presenting to the pediatric Emergency Department. Interviews were conducted in a subset of participants...
March 15, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38493378/designing-an-implementable-clinical-prediction-model-for-near-term-mortality-and-long-term-survival-in-patients-on-maintenance-hemodialysis
#5
JOURNAL ARTICLE
Benjamin A Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L Ephraim, Daniel E Weiner, Tariq Shafi, Julia J Scialla
RATIONALE & OBJECTIVE: The life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care decisions on near-term versus long-term goals. The current tools are limited and focus on near-term mortality. Here, we develop and assess potential utility for predicting near-term mortality and long-term survival on MHD. STUDY DESIGN: Predictive modeling study. SETTING & PARTICIPANTS: 42,351 patients contributing 997,381 patient months over 11 years, abstracted from the electronic health record (EHR) system of midsize, nonprofit dialysis providers...
February 21, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38493340/translational-bioinformatics-and-data-science-for-biomarker-discovery-in-mental-health-an-analytical-review
#6
JOURNAL ARTICLE
Krithika Bhuvaneshwar, Yuriy Gusev
Translational bioinformatics and data science play a crucial role in biomarker discovery as it enables translational research and helps to bridge the gap between the bench research and the bedside clinical applications. Thanks to newer and faster molecular profiling technologies and reducing costs, there are many opportunities for researchers to explore the molecular and physiological mechanisms of diseases. Biomarker discovery enables researchers to better characterize patients, enables early detection and intervention/prevention and predicts treatment responses...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38493316/management-of-anterior-urethral-stricture-a-survey-of-contemporary-practice-of-iranian-urologists
#7
JOURNAL ARTICLE
Jalil Hosseini, Samin Khannejad, Armin Attar, Ali Goudarzikarim
PURPOSE: To evaluate Iranian urologists' approach to urethral stricture and assess how often they select open urethroplasty over minimally invasive procedures. MATERIAL AND METHODS: This cross-sectional observational study was conducted via www. SURVEY: porsline.ir among members of the Iranian urologists' community. The urologists were contacted via email and social media applications (e.g., WhatsApp, Telegram), and data, including their demographic information and years of practice, as well as questions related to their attitude towards the management of urethral stricture, were collected...
March 17, 2024: Urology Journal
https://read.qxmd.com/read/38493288/the-relation-between-usage-of-an-ehealth-intervention-for-stress-urinary-incontinence-and-treatment-outcomes-an-observational-study
#8
JOURNAL ARTICLE
Lotte Firet, Theodora Alberta Maria Teunissen, Rudolf Bertijn Kool, Reinier Peter Akkermans, Antoinette Leonarda Maria Lagro-Janssen, Huub van der Vaart, Willem Jan Jozef Assendelft
BACKGROUND: Stress urinary incontinence (SUI), though a prevalent condition among women, is undertreated in primary care. EHealth with pelvic floor muscle training is an evidence-based alternative to care-as-usual. It is unknown, however, how eHealth usage is related to treatment outcome, and this knowledge is required for general practitioners to implement eHealth in their practice. This study examines the relation between usage of eHealth for SUI and treatment outcomes by examining log data...
March 16, 2024: BMC Prim Care
https://read.qxmd.com/read/38493284/predictors-of-effective-therapy-among-individuals-with-cannabis-use-disorder-a-review-of-the-literature
#9
JOURNAL ARTICLE
Daniel Feingold, Dana Tzur Bitan, Marica Ferri, Eva Hoch
Treatment demand for Cannabis Use Disorder (CUD) has increased in the past decade in almost all European countries, and CUD is currently the most common reason for first-time drug-related treatment admission in the European Union. Even though several therapeutic approaches have been shown to benefit individuals with CUD, there is a lack of knowledge regarding factors associated with effective therapy and the underlying mechanisms of change among individuals with CUD presenting for treatment. The aim of the present paper was to review current knowledge on factors that have been shown to contribute to positive outcomes in CUD treatment...
March 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38493281/impact-of-the-covid-19-pandemic-on-persons-living-with-hiv-in-western-washington-examining-lived-experiences-of-social-distancing-stress-personal-buffers-and-mental-health
#10
JOURNAL ARTICLE
Sarah Smith, Kristin Beima-Sofie, Asad Naveed, Nikki Bhatia, Murugi Micheni, Anh Tuyet Nguyen, Francis Slaughter, Liying Wang, Sandeep Prabhu, Stephaun Wallace, Jane Simoni, Susan M Graham
Pandemic-related stressors may disproportionately affect the mental health of people with HIV (PWH). Stratified, purposive sampling was used to recruit 24 PWH who participated in a quantitative survey on COVID-19 experiences for in-depth interviews (IDIs). IDIs were conducted by Zoom, audio recorded and transcribed. Thematic analysis was used to develop an adapted stress-coping model. Participants experienced acute stress following exposure events and symptoms compatible with COVID-19. Social isolation and job loss were longer-term stressors...
March 16, 2024: AIDS and Behavior
https://read.qxmd.com/read/38493229/progress-report-peutz-jeghers-syndrome
#11
REVIEW
Anne Marie Jelsig, John Gásdal Karstensen, Thomas V Overeem Hansen
Peutz-Jeghers syndrome is a rare, autosomal dominant polyposis syndrome. Presenting with a remarkable phenotype including development of characteristic gastrointestinal polyps, mucocutaneous pigmentations, and an increased risk of cancer, the syndrome has been subject to many studies concerning the natural course of disease. In most patients, pathogenic germline variants are detected in the STK11 gene including cases of mosaicism and structural variants. Yet, studies assessing the effect of surveillance, understanding of cancer development, as well as clinical studies evaluating chemoprevention are lacking...
March 16, 2024: Familial Cancer
https://read.qxmd.com/read/38493138/association-of-interleukin-6-ferritin-and-lactate-dehydrogenase-with-venous-thromboembolism-in-covid-19-a-systematic-review-and-meta-analysis
#12
Haiyu Liu, Ningjing Guo, Qixian Zheng, Qianyuan Zhang, Jinghan Chen, Yuanyuan Cai, Qiong Luo, Qian Xu, Xiangqi Chen, Sheng Yang, Suyun Zhang
BACKGROUND: Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation and immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin and lactate dehydrogenase (LDH) may play an important role in the occurrence of VTE in COVID-19 infection. But whether they can server as predictors for VTE in COVID-19 is still unclear. In this study, we performed a systematic review and meta-analysis to compare IL-6, ferritin and LDH in VTE and non-VTE COVID-19 patients in order to shed light on the prevention and treatment of VTE...
March 16, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38493066/digitising-diabetes-education-for-a-safer-ramadan-design-delivery-and-evaluation-of-massive-open-online-courses-in-ramadan-focused-diabetes-education
#13
JOURNAL ARTICLE
Scott C Mackenzie, Jane Dickson, Salma Mehar, Barakatun Nisak Mohd Yusof, Adhari Alselmi, Bilal Aksi, Mats Stage Baxter, Alex Bickerton, Harnovdeep Singh Bharaj, Nicholas Conway, Kirsten M Cumming, Lee-Ling Lim, Nader Lessan, Nazim Ghouri, Tracey T Flax, Hibbah A Osei-Kwasi, Michelle Es Teo, Salman Waqar, Mohamed Hassanein, Deborah J Wake
AIMS: Ramadan-focused diabetes education is critical to facilitate safer Ramadan fasting amongst Muslim people living with diabetes. We present the design, delivery, and evaluation of two parallel massive open online courses (MOOCs) in Ramadan-focused diabetes education for people with diabetes and HCPs. METHODS: Two Ramadan-focused diabetes education MOOCs were developed and delivered for Ramadan 2023: one for HCPs in English, and another for people with diabetes in English, Arabic and Malay...
March 15, 2024: Primary Care Diabetes
https://read.qxmd.com/read/38492991/online-learning-to-improve-nurses-knowledge-attitudes-and-self-efficacy-about-managing-postoperative-pain-in-older-adults
#14
JOURNAL ARTICLE
Phichpraorn Youngcharoen, Chayada Piyakhachornrot
BACKGROUND: Older adults undergoing total knee arthroplasty may develop chronic pain without effective postoperative pain management. Increasing nurses' knowledge, changing their attitudes, and developing their pain management self-efficacy could improve the effectiveness of pain management. AIM: To determine the effectiveness of an online learning program to help registered nurses to manage postoperative pain in older adults undergoing total knee arthroplasty. DESIGN: A quasi-experimental pre-test-post-test design with intervention and control groups...
March 15, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://read.qxmd.com/read/38492914/providing-adolescents-with-access-to-online-patient-portals-interviews-with-parent-adolescent-dyads
#15
JOURNAL ARTICLE
Bryan A Sisk, Alison L Antes, Christine Bereitschaft, Fabienne Bourgeois, James M DuBois
OBJECTIVE: To identify perceived benefits, problems, facilitators, and barriers to adolescent online patient portal use STUDY DESIGN: Qualitative, semi-structured interviews with dyads of parents and adolescents with or without chronic illness. The study team purposively sampled for racial and ethnic minorities and fathers. Three team members then performed thematic analysis of the transcripts, with subsequent dyadic analysis of themes represented by related parents and adolescents. RESULTS: We performed 102 interviews with 51 dyads of parents and adolescents (26 with chronic illness, 25 without chronic illness)...
March 14, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38492827/good-girl-goes-bad-understanding-how-gut-commensals-cause-disease
#16
REVIEW
Priyankar Dey
This review examines the complex connection between commensal microbiota and the development of opportunistic infections. Several underlying conditions, such as metabolic diseases, malignancies, and weakened immune systems, increase the vulnerability of patients to opportunistic infections. The increasing antibiotic resistance adds significant complexity to the management of infectious diseases. Although commensals have long been considered beneficial, recent research contradicts this notion by uncovering chronic illnesses linked to atypical pathogens or commensal bacteria...
March 14, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38492526/oncological-outcomes-of-intraperitoneal-chemotherapy-in-advanced-ovarian-cancer-brca-mutation-role
#17
JOURNAL ARTICLE
Pablo Padilla-Iserte, Maria Iváñez, Juan Carlos Muruzabal, Rafael Navarro, Berta Díaz-Feijoo, Sara Iacoponi, Virginia García-Pineda, Cristina Díaz, Jesús Utrilla-Layna, Antonio Gil-Moreno, Anna Serra, Juan Gilabert-Estellés, Cristina Martínez Canto, Álvaro Tejerizo, Víctor Lago, José Miguel Cárdenas-Rebollo, Santiago Domingo
INTRODUCTION: The knowledge of BRCA status offers a chance to evaluate the role of the intraperitoneal route in patients selected by biomolecular profiles after primary cytoreduction surgery in advanced ovarian cancer. MATERIALS AND METHODS: We performed a retrospective, multicenter study to assess oncological outcomes depending on adjuvant treatment (intraperitoneal [IP] vs intravenous [IV]) and BRCA status (BRCA1/2 mutated vs. BRCA wild type [WT]). The primary endpoint was to determine progression-free survival...
March 9, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492434/association-of-maternal-blood-high-mobility-group-box-1-levels-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis
#18
REVIEW
Liping Xue, Ruolin Chen, Ying Liu, Peiguang Niu, Jintuo Zhou, Jinhua Liu, Jinhua Zhang, Huajiao Chen
Conflicting findings have emerged regarding the levels of high mobility group box 1 (HMGB1) in individuals experiencing adverse pregnancy outcomes. Here we conducted a meta-analysis to assess the association between maternal blood HMGB1 levels and adverse pregnancy outcomes. Utilizing databases such as PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Embase and China National Knowledge Infrastructure (CNKI), a systematic literature search was conducted in January 2024. Eligible literature was screened according to inclusion and exclusion criteria...
March 15, 2024: Reproductive Biology
https://read.qxmd.com/read/38492407/cybersecurity-and-critical-care-staff-a-mixed-methods-study
#19
JOURNAL ARTICLE
Kevin Hore, Mong Hoi Tan, Anne Kehoe, Aidan Beegan, Sabina Mason, Nader Al Mane, Deirdre Hughes, Caroline Kelly, John Wells, Claire Magner
INTRODUCTION: Cyberattacks on healthcare organisations are becoming increasingly common and represent a growing threat to patient safety. The majority of breaches in cybersecurity have been attributed to human error. Intensive care departments are particularly vulnerable to cyberattacks. The aim of this study was to investigate cybersecurity awareness, knowledge and behaviours among critical care staff. METHODS: This was a multi-site cross-sectional survey study administered to critical care staff...
March 13, 2024: International Journal of Medical Informatics
https://read.qxmd.com/read/38492315/robot-assisted-radical-nephroureterectomy-for-right-renal-pelvic-tumor-post-sacrocolpopexy-with-mesh-a-case-report
#20
Koki Sugimura, Satoru Kira, Hiroshi Shimura, Takanori Mochizuki, Norifumi Sawada, Takahiko Mitsui
INTRODUCTION: Robot-assisted nephroureterectomy for upper tract urothelial carcinoma has been increasingly performed as a minimally invasive procedure recently. However, there are concerns regarding its adoption in highly complex cases with dense adhesions. PRESENTATION OF CASE: An 86-year-old woman presented to our hospital with gross hematuria one year after having undergone robot-assisted sacrocolpopexy using a mesh for pelvic organ prolapse. Cystoscopy revealed hematuria from the right ureteral orifice...
March 15, 2024: International Journal of Surgery Case Reports
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