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https://www.readbyqxmd.com/read/28213145/how-are-you-feeling-a-personalized-methodology-for-predicting-mental-states-from-temporally-observable-physical-and-behavioral-information
#1
Suppawong Tuarob, Conrad S Tucker, Soundar Kumara, C Lee Giles, Aaron L Pincus, David E Conroy, Nilam Ram
It is believed that anomalous mental states such as stress and anxiety not only cause suffering for the individuals, but also lead to tragedies in some extreme cases. The ability to predict the mental state of an individual at both current and future time periods could prove critical to healthcare practitioners. Currently, the practical way to predict an individual's mental state is through mental examinations that involve psychological experts performing the evaluations. However, such methods can be time and resource consuming, mitigating their broad applicability to a wide population...
February 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28182613/news-on-viral-hepatitis-in-hiv-update-from-the-2016-gehep-conference
#2
Eva Poveda, Massimo Puoti, Miguel García-Deltoro, Juan A Pineda, Francisco Téllez, Rafael Granados, Luis Morano, Federico García
The II Conference of the Group for the Study of Viral Hepatitis (GEHEP) (29 September-1 October, Spain) updated epidemiological, diagnostic and treatment aspects on viral hepatitis. The conference was mostly focused on the latest news related to HCV infection, including the successes achieved since the implementation of direct-acting antiviral agents for HCV therapy, but also in the new, future challenges for a real HCV eradication. The scenario for chronic HCV infection has dramatically changed in the last two years and most patients have been cured after 12 weeks of therapy with minimal side effects...
January 2017: AIDS Reviews
https://www.readbyqxmd.com/read/28167576/phase-relations-in-a-forced-turbulent-boundary-layer-implications-for-modelling-of-high-reynolds-number-wall-turbulence
#3
Subrahmanyam Duvvuri, Beverley McKeon
Phase relations between specific scales in a turbulent boundary layer are studied here by highlighting the associated nonlinear scale interactions in the flow. This is achieved through an experimental technique that allows for targeted forcing of the flow through the use of a dynamic wall perturbation. Two distinct large-scale modes with well-defined spatial and temporal wavenumbers were simultaneously forced in the boundary layer, and the resulting nonlinear response from their direct interactions was isolated from the turbulence signal for the study...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28165866/direct-quantification-of-autophagic-flux-by-a-single-molecule-based-probe
#4
Jiefei Geng, Daniel J Klionsky
Macroautophagy/autophagy remains a rapidly advancing research topic, and there continues to be a need for constantly evolving methodology to investigate this pathway at each individual step. Accordingly, new assays to measure autophagic flux in a robust and reliable manner are essential to understand the mechanism and physiological roles of autophagy. Kaizuka et al. recently reported a new fluorescence probe, GFP-LC3-RFP-LC3δG to directly demonstrate autophagic flux without being combined with lysosomal inhibitors (see the punctum in this issue of the journal)...
February 6, 2017: Autophagy
https://www.readbyqxmd.com/read/28165829/an-overview-of-nanofiber-based-antibacterial-drug-design
#5
Semih Calamak, Reza Shahbazi, Ipek Eroglu, Merve Gultekinoglu, Kezban Ulubayram
Introduction Conventional administration of antibacterial drugs to the human body can cause vital problems such as dose dependent systemic toxicity and bacterial resistance which prevent the healing process. In this regard, recent studies have been devoted to producing nanofiber based antibacterial drug delivery approaches which surpass bacterial resistance and toxicological issues. Areas covered This review summarizes latest developments in the production of antibacterial nanofibers, nanofiber based antibacterial action mechanisms and release profiles of nanofibers...
February 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28163129/biotransformation-of-lignocellulosic-materials-into-value-added-products-a-review
#6
REVIEW
Muhammad Bilal, Muhammad Asgher, Hafiz M N Iqbal, Hongbo Hu, Xuehong Zhang
In the past decade, with the key biotechnological advancements, lignocellulosic materials have gained a particular importance. In serious consideration of global economic, environmental and energy issues, research scientists have been re-directing their interests in (re)-valorizing naturally occurring lignocellulosic-based materials. In this context, lignin-modifying enzymes (LMEs) have gained considerable attention in numerous industrial and biotechnological processes. However, their lower catalytic efficiencies and operational stabilities limit their practical and multipurpose applications in various sectors...
February 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28156497/the-integration-of-palliative-care-into-treatment-of-oncology-patients-at-the-istituto-oncologico-veneto-iov-the-interdisciplinary-clinic-of-simultaneous-care
#7
Stefania Schiavon, Antonella Brunello, Michela Michielotto, Irene Guglieri, Maria Teresa Nardi, Evelina Lamberti, Annalisa Stablum, Eleonora Capovilla, Leonardo Trentin, Vittorina Zagonel
: 150 Background: WHO defines palliative care as an approach that improves the quality of life of patients (pts) and their families facing problems associated with life threatening illnesses. This occurs by means of early identification, assessment and treatment of pain and other problems physical, psychosocial, and spiritual. Recently, palliative care has been incorporated into the treatment of oncology pts earlier in the course of their disease. We aimed to explore this approach at our institution...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152760/patients-as-partners-in-managing-cancer-treatment-related-toxicity
#8
Kathy Vu, Meaghan Wright, Colleen Fox, Noor Ahmad, Vicky Simanovski, Leonard Kaizer, Monika K Krzyzanowska
: 215 Background: Cancer Care Ontario is the government agency responsible for improving cancer services across Ontario's 14 regions. To promote advances in best practices related to systemic treatment, Cancer Care Ontario hosts annual Systemic Treatment Safety Symposia, which serve as a platform to discuss quality and safety issues and results of quality improvement (QI) initiatives in alignment with the Systemic Treatment Provincial Plan. For the first time, the 2015 Symposium brought together patients and providers to discuss gaps and opportunities for improvement in relation to toxicity management (TM) during chemotherapy...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151827/ethics-of-research-for-patients-in-pain
#9
David B Waisel
PURPOSE OF REVIEW: This review describes advances in rising and continuing ethical issues in research in patients in pain. Although some of the issues focus directly on pain research, such as research in neonatal pain management, others focus on widespread ethical issues that are relevant to pain research, such as scientific misconduct, deception, placebo use and genomics. RECENT FINDINGS: Scientific misconduct is more widespread than realized and requires greater awareness of the markers of misconduct like irreproducibility...
February 1, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28147212/advance-care-directive-documentation-issues-for-clinicians-in-new-south-wales
#10
Mark I Friedewald, Peter A Cleasby
Objective The aim of the present study was to assess the characteristics of documents presented as advance care directives (ACDs) at a public health organisation in New South Wales (NSW). It was envisaged that the findings would inform the refinement of locally developed educational strategies.Methods All ACD documents provided during hospital admissions and entered into the electronic medical record system over a 12-month period were reviewed. An audit tool was developed and used to identify whether key requirements for ACDs in NSW had been addressed...
February 2, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28140351/predicting-path-from-undulations-for-i-c-elegans-i-using-linear-and-nonlinear-resistive-force-theory
#11
Eric Keaveny, Andre Brown
A basic issue in the physics of behaviour is the mechanical relationship between an animal and its surroundings. The model nematode <i>C. elegans</i> provides an excellent platform to explore this relationship due to its anatomical simplicity. Nonetheless, the physics of nematode crawling, in which the worm undulates its body to move on a wet surface, is not completely understood and the mathematical models often used to describe this phenomenon are empirical. We confirm that linear resistive force theory, one such empirical model, is effective at predicting a worm's path from its sequence of body postures for forward crawling, reversing, and turning and for a broad range of different behavioural phenotypes observed in mutant worms...
January 31, 2017: Physical Biology
https://www.readbyqxmd.com/read/28138072/eukaryotic-aspects-of-translation-initiation-brought-into-focus
#12
REVIEW
Christopher H S Aylett, Nenad Ban
In all organisms, mRNA-directed protein synthesis is catalysed by ribosomes. Although the basic aspects of translation are preserved in all kingdoms of life, important differences are found in the process of translation initiation, which is rate-limiting and the most important step for translation regulation. While great strides had been taken towards a complete structural understanding of the initiation of translation in eubacteria, our understanding of the eukaryotic process, which includes numerous eukaryotic-specific initiation factors, was until recently limited owing to a lack of structural information...
March 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28135824/primer-in-genetics-and-genomics-article-2-advancing-nursing-research-with-genomic-approaches
#13
Hyunhwa Lee, Jessica Gill, Taura Barr, Sijung Yun, Hyungsuk Kim
PURPOSE: Nurses investigate reasons for variable patient symptoms and responses to treatments to inform how best to improve outcomes. Genomics has the potential to guide nursing research exploring contributions to individual variability. This article is meant to serve as an introduction to the novel methods available through genomics for addressing this critical issue and includes a review of methodological considerations for selected genomic approaches. APPROACH: This review presents essential concepts in genetics and genomics that will allow readers to identify upcoming trends in genomics nursing research and improve research practice...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28135379/comparison-of-nurses-self-reported-and-objectively-measured-evidence-based-practice-knowledge
#14
Amy Hagedorn Wonder, Angela M McNelis, Darrell Spurlock, Pamela M Ironside, Shelley Lancaster, Carmen R Davis, Marlena Gainey, Nancy Verwers
BACKGROUND: This study provides a first-time, objective assessment of the evidence-based practice (EBP) knowledge of RNs working in Magnet(®)-designated hospitals. METHOD: This multisite, cross-sectional, descriptive, correlational study uses the Evidence-Based Practice Knowledge Assessment in Nursing (EKAN) and Evidence-Based Practice Questionnaire (EBPQ). RESULTS: EBPQ subscale scores revealed overall positive self-ratings of EBP knowledge/skills, attitudes, and practice/use...
1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28132673/recent-advances-in-the-study-and-design-of-parahydrophobic-surfaces-from-natural-examples-to-synthetic-approaches
#15
REVIEW
Caroline R Szczepanski, Frédéric Guittard, Thierry Darmanin
Parahydrophobic surfaces are an interesting class of materials that combines both high contact angles and very strong adhesion with wetting fluids, most commonly water. This unique set of properties makes parahydrophobic surfaces attractive for a variety of applications, including water harvesting and collection, guided fluid transport, and membrane development, amongst many others. Taking inspiration from natural surfaces that display this same behavior such as rose petals and gecko feet, synthetic approaches aim to incorporate the nano- and micro-scale topography as well as the low surface energy chemistry found on these interfaces...
January 19, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28125354/engineered-probiotics-applications-and-biological-containment
#16
Babasola Sola-Oladokun, Eamonn P Culligan, Roy D Sleator
Bioengineered probiotics represent the next generation of whole cell-mediated biotherapeutics. Advances in synthetic biology, genome engineering, and DNA sequencing and synthesis have enabled scientists to design and develop probiotics with increased stress tolerance and the ability to target specific pathogens and their associated toxins, as well as to mediate targeted delivery of vaccines, drugs, and immunomodulators directly to host cells. Herein, we review the most significant advances in the development of this field...
January 11, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28125261/solving-the-supreme-problem-100-years-of-selection-and-recruitment-at-the-journal-of-applied-psychology
#17
Robert E Ployhart, Neal Schmitt, Nancy T Tippins
This article reviews 100 years of research on recruitment and selection published in the Journal of Applied Psychology. Recruitment and selection research has been present in the Journal from the very first issue, where Hall (1917) suggested that the challenge of recruitment and selection was the Supreme Problem facing the field of applied psychology. As this article shows, the various topics related to recruitment and selection have ebbed and flowed over the years in response to business, legal, and societal changes, but this Supreme Problem has captivated the attention of scientist-practitioners for a century...
January 26, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28117169/can-intersectional-innovations-reduce-hospital-infection
#18
S Saint
Preventing healthcare-associated infection remains an international priority given the clinical and economic consequences of this largely preventable patient safety harm. Whereas important strides have been made in preventing hospital infections over the past several decades, thorny issues remain, including how to consistently improve hand hygiene rates and further reduce device-related complications such as catheter-associated urinary tract infection. Rather than relying solely on directional innovations - incremental changes that continue to serve as the bedrock of scientific advancement - perhaps we should also search for 'intersectional innovations', which represent breakthrough discoveries that emanate from the intersection of often widely divergent disciplines...
February 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28116225/hyperbaric-oxygen-therapy-for-the-compromised-graft-or-flap
#19
REVIEW
Ashish Francis, Richard C Baynosa
Significance: Tissue grafts and flaps are used to reconstruct wounds from trauma, chronic disease, tumor extirpation, burns, and infection. Despite careful surgical planning and execution, reconstructive failure can occur due to poor wound beds, radiation, random flap necrosis, vascular insufficiency, or ischemia-reperfusion (IR). Traumatic avulsions and amputated composite tissues-compromised tissue-may fail from crush injury and excessively large sizes. While never intended, these complications result in tissue loss, additional surgery, accrued costs, and negative psychosocial patient effects...
January 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28111335/assessment-of-abilities-of-gastroenterology-fellows-to-provide-information-to-patients-with-liver-disease
#20
Noami Chaudhary, Catherine Lucero, Gerald Villanueva, Michael Poles, Colleen Gillespie, Sondra Zabar, Elizabeth Weinshel
PURPOSE: Patient education is critical in ensuring patient compliance and good health outcomes. Fellows must be able to effectively communicate with their patients, delivering enough information for the patient to understand their medical problem and maximize patient compliance. We created an objective structured clinical examination (OSCE) with four liver disease cases to assess fellows' knowledge and ability to inform standardized patients about their clinical condition. METHODS: We developed four cases highlighting different aspects of liver disease and created a four station OSCE: hepatitis B, acute hepatitis C, new diagnosis of cirrhosis, and an end-stage cirrhotic non transplant candidate...
January 19, 2017: Clinical Gastroenterology and Hepatology
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