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Velvet antler

Enhui Zha, Li Dandan, Xue Bai, Tiezhong Zhou, Yongong Li, Gao Shenyang, Xiqing Yue
CONTEXT: Velvet antler (VA) is recognized as one of the most important Chinese traditional medical herbs. To date, the immunoactivity of the single component of VA is rarely studied though its compound extracts have been well analyzed. OBJECTIVE: The current study was designed to evaluate the immunomodulatory effects of a recombinant polypeptide (rVAP32) based on the VA of the sika deer by comparison with its natural counterpart (nVAP32). MATERIALS AND METHODS: Splenocytes proliferation and NK-cell cytotoxicity assay was evaluated by the WST-8 colorimetric method...
September 7, 2016: Immunopharmacology and Immunotoxicology
Hye Kyung Kim, Myung-Gyou Kim, Kang-Hyun Leem
The aim of this study was to compare the effectiveness of velvet antler (VA) from different sections for promoting longitudinal bone growth in growing rats. VA was divided into upper (VAU), middle (VAM), and basal sections (VAB). An in vivo study was performed to examine the effect on longitudinal bone growth in adolescent rats. In addition, in vitro osteogenic activities were examined using osteoblastic MG-63 cells. VA promoted longitudinal bone growth and height of the growth plate in adolescent rats. Bone morphogenetic protein-2 (BMP-2) in growth plate of VA group was highly expressed compared with control...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Seung-Hong Lee, Hye-Won Yang, Yuling Ding, Yanmei Wang, You-Jin Jeon, Sang-Ho Moon, Byong-Tae Jeon, Si-Heung Sung
Enzymatic hydrolysis has been successfully used for the extraction of numerous biologically active components from a wide variety of natural sources. In the present study, velvet antler was subjected to the extraction process using Alcalase protease. We analyzed bioactive components, such as uronic acid, sulfated-glycosaminoglycans (sulfated-GAGs), and sialic acid, present in the velvet antler Alcalase hydrolysate (VAAH) and assessed their anti-inflammatory effects in zebrafish as well as in vitro using cell lines...
2015: EXCLI journal
Lihong Zhao, Yang Mi, Hongya Guan, Yan Xu, Yingwu Mei
Velvet antlers (VAs) are commonly used in traditional Chinese medicine and invigorant and contain many functional components for health promotion. The velvet antler peptide sVAP32 is one of active components in VAs; based on structural study, the sVAP32 interacts with TGF-β1 receptors and disrupts the TGF-β1 pathway. We hypothesized that sVAP32 prevents cardiac fibrosis from pressure overload by blocking TGF-β1 signaling. Sprague-Dawley rats underwent transverse aortic constriction (TAC) or a sham operation...
July 15, 2016: European Journal of Pharmacology
YuJiao Tang, Byong-Tae Jeon, Yanmei Wang, Eun-Ju Choi, Yon-Suk Kim, Jin-Woo Hwang, Pyo-Jam Park, Sang Ho Moon, Eun-Kyung Kim
Deer velvet antler (DVA) is one of the most popular medicines in China. Numerous studies have demonstrated that velvet antler possess biological effects. However, data regarding its anti-migration activity on prostate cancer is scarce. In this study, we investigated the inhibitory effect of top DVA (T-DVA) on the expression of prostate-specific antigen (PSA) and migration-related genes in the human prostate cancer cell, LNCaP. The T-DVA down-regulated the expression of PSA. In addition, the Radius(TM) assay revealed that T-DVA inhibited the migration behavior of prostate cancer cells...
2015: Korean Journal for Food Science of Animal Resources
Zhi-Jun Zang, Hong-Feng Tang, Ying Tuo, Wei-Jie Xing, Su-Yun Ji, Yong Gao, Chun-Hua Deng
Twenty-four-month-old male C57BL/6 mice with low serum testosterone levels were used as a late-onset hypogonadism (LOH) animal model for examining the effects of velvet antler polypeptide (VAP) on sexual function and testosterone synthesis. These mice received VAP for 5 consecutive weeks by daily gavage at doses of 100, 200, or 300 mg kg-1 body weight per day (n = 10 mice per dose). Control animals (n = 10) received the same weight-based volume of vehicle. Sexual behavior and testosterone levels in serum and interstitial tissue of testis were measured after the last administration of VAP...
July 2016: Asian Journal of Andrology
Sung-Hui Tseng, Lih-Geeng Chen, Ying-Jang Lai, Kun-Teng Wang, Ching-Chiung Wang
For this study, we aimed to assess the dose-response antiosteoporotic effects of the middle section of velvet antlers (VAs) from sika deers (Cervus nippon) fed with different types of fodders. VAs prepared from farmed sika deers fed with feed mixtures containing sorghum distillery residue (VA-SDR) or without SDR (SDR replaced with hay, VA-Hay) were divided into upper (VAU), middle (VAM) and basal (VAB) sections. The chemical constituents of the middle sections obtained from each VA type were compared, and their antiosteoporotic activities were evaluated using rats with ovaries removed surgically (ovariectomy, OVX)...
August 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
Jiongran Chen, Yanfei Yang, Sepideh Abbasi, Daryoush Hajinezhad, Saija Kontulainen, Ali Honaramooz
Elk velvet antler (EVA) has been used in traditional Oriental medicine for centuries to promote general health; however, little evidence for its effect on bone development is available. We investigated the effects of lifelong exposure of Wistar rats to a diet containing 10% EVA on physical growth and bone development. Measurements included weekly body weights, blood chemistry and kidney and testis/ovary indices (sacrificed at 5, 9, or 16 weeks of age), and bone traits of the femur bones by peripheral quantitative computed tomography (pQCT)...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Dayong Tao, Jinxiang Zhao, Ganzhen Deng, Jifeng Jiao
Ossification degree is one of the primary variables affecting the medicinal value of velvet antler. Multiple factors regulate the calcification of velvet antler. We studied the relationship between the ossification of velvet antlers and the serum levels of parathyroid hormone (PTH) and androgen (ADG) in Tarim red deer. Enzyme-linked immunosorbent assays (ELISA) and atomic absorption spectrometry demonstrated that the changes in serum PTH and ADG levels nearly paralleled antler ossification during Tarim red deer antler mineralization...
September 9, 2015: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
Jaehyun Park, Byongtae Jeon, Sungki Kang, Mirae Oh, Myonghwa Kim, Seyoung Jang, Pyojam Park, Sangwoo Kim, Sangho Moon
This study was conducted to investigate changes in blood enzyme parameters and to evaluate the relationship between insulin-like growth factor-1 (IGF-1), antler growth and body weight during the antler growth of sika deer (Cervus nippon). Serum enzyme activity and IGF-1 concentrations were measured in blood samples collected from the jugular and femoral veins at regular intervals during the antler growth period. Blood samples were taken in the morning from fasted stags (n = 12) which were healthy and showed no clinical signs of disease...
September 2015: Asian-Australasian Journal of Animal Sciences
Jeong Jin Ahn, Youngjoo Kim, Ji Young Hong, Gi Won Kim, Seung Yong Hwang
Velvet antlers are used medicinally in Asia and possess various therapeutic effects. Prices are set according to the country of origin, which is unidentifiable to the naked eye, and therefore counterfeiting is prevalent. Additionally, antlers of the Canadian elk, which can generate chronic wasting disease, are prevalently smuggled and distributed in the market. Thus, a method for identifying the country of origin of velvet antlers was developed, using polymorphisms in mitochondrial DNA, fluorescence melting curve analysis and analysis of locked nucleic acids (LNA)...
July 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Amy P Myers, Troy A Watson, Steven B Strock
The likelihood of a drug reaction with lamotrigine is increased by dose escalation that is too rapid or drug interactions that increase the concentration of lamotrigine. There is a well-documented interaction between valproic acid and lamotrigine in which lamotrigine levels are increased, subsequently increasing the risk of a drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. This syndrome is characterized by fever, lymphadenopathy, diffuse maculopapular rash, multivisceral involvement, eosinophilia, and atypical lymphocytes and has a mortality rate of 10-40%...
March 2015: Pharmacotherapy
Karen A Fox, Brandon Diamond, Feng Sun, Alfonso Clavijo, Loyd Sneed, Donald N Kitchen, Lisa L Wolfe
Antler abnormalities of deer and other cervids often result from testicular lesions and decreased levels of testosterone, inhibiting normal cycles of antler growth. Affected males have antlers with retained velvet, numerous short, misshapen points ("cactus bucks"), and failure to shed these abnormal antlers annually. In Colorado, US, we observed a high occurrence of "cactus bucks" in mule deer (Odocoileus hemionus) populations after management efforts to increase the number of mature male deer in the state...
January 2015: Journal of Wildlife Diseases
Yu-Shu Huo, Hong Huo, Jie Zhang
Deer velvet antler is the only mammal organ which can continuous regenerate. Currently, international scholars are interested in antler that is defined as a perfect regeneration model of neuro, blood vessel, connective tissue, cartilage, and bones. In 1986, we started to study the separation of active protein and peptide of fresh velvet antler using classic biochemical methods. After entering the 21st century, we further investigated the differentiation of antler proteome from different growth periods using advance differential proteomics approach, and unveiled the correlation between the proteome difference and life cycle...
October 2014: Chinese Journal of Integrative Medicine
Guangxin Yuan, Jiyan Sun, Hongyu Li, Guilian Fu, Guangyu Xu, Mingcheng Li, Lihua Zhang, Xintian Fan
Mitochondrial DNA of velvet antler was amplified with random amplified polymorphic DNA (RAPD) technique and the PCR products were detected with non-gel sieving capillary electrophoresis to establish a RAPD-HPCE method used for identifying the authenticity of velvet antler or it counterfeits. Factors that could affect the PCR amplification and capillary electrophoresis were optimized. Under the optimized conditions, namely, 20 mmol L(-1) NaH2PO4-Na2HPO4-2 mmol L(-1) EDTA buffer solution [0.8% (W/V) HPMC, 15 mmol L(-1) TBAP and pH 7...
2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
L Bartoš
A five-year observation of social interactions and the antler cycle of the stag was performed in the "white" red deer population in the Žehušice game reserve, Czechoslovakia. The results indicate that the antler casting time of individual stags was dependent primarily on social status and that the influence of age was of secondary importance. The more dominant the stag, the earlier antler casting occurred. The stags of higher social status also tended to shed velvet earlier, although this relationship was not significant...
December 1980: Behavioural Processes
Hiroaki Nishimatsu, Tadaichi Kitamura, Daisuke Yamada, Akira Nomiya, Aya Niimi, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Tohru Nakagawa, Yutaka Enomoto, Haruki Kume, Yasuhiko Igawa, Yukio Homma
"LEOPIN ROYAL®" (LER), a non-prescription health-promoting medication in Japan, is a preparation containing six natural medicines, namely, aged garlic extract, ginseng, oriental bezoar, velvet antler, cuscuta seed and epimedium herb. To determine the effect of LER on symptoms of aging in males, we conducted an open-labeled, randomized clinical trial using Kampo (mainly kamishoyosan) as a control. Forty-nine male patients (age, 62.7 (SD 11.8) years) with mild or more pronounced symptoms of aging were enrolled and randomly assigned to the LER (n = 24) or Kampo group (n = 25) for 6 months...
June 2014: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
B A Munk, E Garrison, B Clemons, M Kevin Keel
A 2-year-old male free-ranging white-tailed deer (Odocoileus virginianus) was diagnosed with bilateral expansile tumors of antler origin. The deer was found dead by a landowner in High Springs, Florida. Two roughly spherical, multilobular, broad-based, bony, velvet-covered masses originated from each antler pedicle. These masses replaced or displaced many of the bones and soft tissues of the skull and extended through the left cribriform plate and the right petrous temporal bone, compressing portions of the brain...
January 2015: Veterinary Pathology
I I Antipova, I N Smirnova, L V Barabash, A O Naumov, O V Dostovalova, N I Kuleshova
We have developed the method for the treatment of the patients presenting with arterial hypertension and concomitant chronic psychoemothional overtension. The method consists of the application of the baths containing the Siberian Stag velvet antler extracts in combination with exercise therapy and massage. A total of 35 patients with arterial hypertension and concomitant chronic psychoemothional overtension were enrolled in the study. It was shown that inclusion of the baths containing the Siberian Stag velvet antler extracts in the combined treatment of arterial hypertension and concomitant chronic psychoemothional overtension has positive effect on the parameters of the main homeostatic systems, enhances the working capacity of the patients, promotes their psychological stability, and increases the adaptive potential of the organism...
January 2014: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Fei-Fei Yang, Li-Jun Huo, Li-Guo Yang, Hasan Riaz, Li-Rong Xiong, Jian-Guo Chen, Shu-Jun Zhang, Jia-Jun Xiong
Melatonin, a secretion from pineal gland is ambiguously considered as the key hormone involved in regulation of the antler cycle in Sika deer. To find out more about the roles of melatonin and its receptor gene, we carried out current study to investigate the association between polymorphisms in melatonin receptor 1A (MTNR1A) gene and the antler yield from Sika deer. A total of 251 Sika deer were analyzed in this study, of which consisted of Wusan Sika deer (n = 163) and Dongfeng Sika deer (n = 88). MTNRA gene was amplified by PCR and genotyped by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
2014: Molecular Biology Reports
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