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https://www.readbyqxmd.com/read/29774141/exosome-mediated-peritoneal-dissemination-in-gastric-cancer-and-its-clinical-applications
#1
REVIEW
Kai-Bo Chen, Jian Chen, Xiao-Li Jin, Yi Huang, Qiu-Ming Su, Li Chen
The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29739756/alternatively-activated-macrophages-upregulate-mesothelial-expression-of-p-selectin-to-enhance-adhesion-of-ovarian-cancer-cells
#2
Molly J Carroll, Kaitlin C Fogg, Harin A Patel, Harris B Krause, Anne-Sophie Mancha, Manish S Patankar, Paul S Weisman, Lisa Barroilhet, Pamela K Kreeger
Peritoneal metastasis of high-grade serous ovarian cancer (HGSOC) occurs when tumor cells suspended in ascites adhere to mesothelial cells. Despite the strong relationship between metastatic burden and prognosis in HGSOC, there are currently no therapies specifically targeting the metastatic process. We utilized a co-culture model and multivariate analysis to examine how interactions between tumor cells, mesothelial cells, and alternatively-activated macrophages (AAMs) influence the adhesion of tumor cells to mesothelial cells...
May 8, 2018: Cancer Research
https://www.readbyqxmd.com/read/29731861/analysis-of-yap1-and-taz-expression-by-immunohistochemical-staining-in-malignant-mesothelioma-and-reactive-mesothelial-cells
#3
Yusuke Takehara, Toshiko Yamochi, Tasuku Nagumo, Tomonari Cho, Fumihiko Urushibara, Kohei Ono, Tomonori Fujii, Naoko Okamoto, Yosuke Sasaki, Sakiko Tazawa, Mayumi Honma, Tomoko Norose, Eisuke Shiozawa, Genshu Tate, Masafumi Takimoto
Gene mutations are involved in the development of malignant mesothelioma. Important mutations have been identified in the genes for cyclin-dependent kinase inhibitor 2A (p16) alternative reading frame, breast cancer-associated protein 1 ( BAP1 ) and neurofibromatosis type 2 ( NF2 ). Previously, the utility of detecting the loss of BAP1 by immunohistochemistry (IHC) and p16-deletion by fluorescence in situ hybridization has been identified in several studies. However, NF2 -associated examinations have not been performed...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29714452/increased-micronucleus-count-predicts-malignant-behavior-in-pleural-effusion-fluid
#4
Tuba Dilay Kökenek Ünal, İpek Çoban
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk. The aim of this study was to evaluate the diagnostic usefulness of MN frequency to differentiate between malignant and benign pleural effusion samples. Materials and methods: Retrospectively, 78 pleural fluid cytology samples (including 20 cases of benign reactive mesothelial cells, 22 cases of suspicious cytology, and 36 cases of malignant cytology) were examined. The number of micronucleated cells in 1000 well- preserved cells was counted...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29707109/mir-21-over-expression-and-programmed-cell-death-4-down-regulation-features-malignant-pleural-mesothelioma
#5
Lorenzo Nicolè, Rocco Cappellesso, Tiziana Sanavia, Vincenza Guzzardo, Ambrogio Fassina
Background: Differential diagnosis between malignant pleural mesothelioma (MPM) and benign mesothelial conditions is still challenging and there is a lack of useful markers. Programmed cell death 4 (PDCD4) is a well-known tumor suppressor gene in several cancers, its post-transcriptional activity is directly controlled by miR-21, whose over-expression has been recently reported in MPM compared to normal mesothelium. Aim of this study was to test this suppressor gene as a possible new marker of malignant transformation in mesothelial cells, as well as a new prognostic marker...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29692588/value-of-cytokeratin-19-hector-battifora-mesothelial-1-and-galectin-3-immunostaining-in-the-diagnosis-of-thyroid-neoplasms
#6
Rajasekhar Sanuvada, Rukmangadha Nandyala, Amit Kumar Chowhan, Phaneendra Bobbidi, Mutheeswariah Yootla, Narendra Hulikal, Alok Sachan
BACKGROUND: Diagnosis of types and aggressiveness of thyroid cancers is difficult. The "gold standard" in diagnosis is using routine hematoxylin and eosin staining. Several markers have been investigated for differentiating them among which cytokeratin-19 (CK-19), Hector Battifora mesothelial cell (HBME-1), and galectin-3 are found to be most commonly used. Most studies have evaluated the single expression of markers in various thyroid lesions. AIMS AND OBJECTIVES: To know the value of immunohistochemical expression of CK-19, HBME-1, and galectin-3 in diagnosing thyroid neoplasms...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29662326/cd133-promotes-adhesion-to-the-ovarian-cancer-metastatic-niche
#7
Lynn Roy, Alexander Bobbs, Rachel Sattler, Jeffrey L Kurkewich, Paige B Dausinas, Prakash Nallathamby, Karen D Cowden Dahl
Cancer stem cells (CSCs) are an attractive therapeutic target due to their predicted role in both metastasis and chemoresistance. One of the most commonly agreed on markers for ovarian CSCs is the cell surface protein CD133. CD133+ ovarian CSCs have increased tumorigenicity, resistance to chemotherapy, and increased metastasis. Therefore, we were interested in defining how CD133 is regulated and whether it has a role in tumor metastasis. Previously we found that overexpression of the transcription factor, ARID3B , increased the expression of PROM1 (CD133 gene) in ovarian cancer cells in vitro and in xenograft tumors...
2018: Cancer Growth and Metastasis
https://www.readbyqxmd.com/read/29572256/preclinical-evaluation-of-novel-mesothelin-specific-ligands-for-spect-imaging-of-triple-negative-breast-cancer
#8
Christopher Montemagno, Sandrine Bacot, Mitra Ahmadi, Brigitte Kerfelec, Daniel Baty, Marlene Debiossat, Audrey Soubies, Pascale Perret, Laurent Riou, Daniel Fagret, Alexis Broisat, Catherine Ghezzi
Background: Mesothelin is a cell-surface glycoprotein restricted to mesothelial cells overexpressed in several cancers, including triple negative breast cancers (TNBC) not responding to trastuzumab and hormonal-based therapies. Mesothelin-targeting therapies are currently being developed. However, the identification of patients potentially eligible to such therapeutic strategy remains challenging. The objective of this study was to perform the radiolabeling and pre-clinical evaluation of99m Tc-A1 and99m Tc-C6, two anti-mesothelin single domain antibodies (sdAb)-derived imaging agents...
March 23, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29553831/exosomes-from-asbestos-exposed-cells-modulate-gene-expression-in-mesothelial-cells
#9
Phillip Munson, Ying-Wai Lam, Julie Dragon, Maximilian MacPherson, Arti Shukla
Asbestos exposure is a determinate cause of many diseases, such as mesothelioma, fibrosis, and lung cancer, and poses a major human health hazard. At this time, there are no identified biomarkers to demarcate asbestos exposure before the presentation of disease and symptoms, and there is only limited understanding of the underlying biology that governs asbestos-induced disease. In our study, we used exosomes, 30-140 nm extracellular vesicles, to gain insight into these knowledge gaps. As inhaled asbestos is first encountered by lung epithelial cells and macrophages, we hypothesize that asbestos-exposed cells secrete exosomes with signature proteomic cargo that can alter the gene expression of mesothelial cells, contributing to disease outcomes like mesothelioma...
March 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29550585/mitochondria-related-oxidative-stress-contributes-to-ovarian-cancer-promoting-activity-of-mesothelial-cells-subjected-to-malignant-ascites
#10
Martyna Pakuła, Justyna Mikuła-Pietrasik, Łukasz Stryczyński, Paweł Uruski, Sebastian Szubert, Rafał Moszyński, Dariusz Szpurek, Stefan Sajdak, Andrzej Tykarski, Krzysztof Książek
Very little is known about the mechanisms by which malignant ascites modulates the cancer-promoting activity of human peritoneal mesothelial cells (HPMCs). Because malignant ascites induces pro-tumoral senescence in HPMCs, here we examined if this effect could be driven by oxidative stress. The study showed that malignant ascites generated by serous ovarian tumors induced oxidative damage to the DNA (γH2A.X, 53BP1, 8-hydroxy-2'-deoxyguanosine) and lipids (8-isoprostane) in HPMCs as well as increased the production of mitochondrial superoxides and cellular peroxides in these cells...
May 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29534357/-value-of-immunocytochemistry-in-differential-diagnosis-of-gastric-adenocarcinoma-reactive-mesothelial-cells-and-malignant-epithelial-mesothelioma-in-metastatic-effusion-fluid
#11
M Lyu, N Cha, Y F Zou, J H Leng, L Xu, Y Sun, Y Y Hao
Objective: To investigate the diagnostic value of some antibodies in peritoneal fluid of patients with gastric cancer and malignant epithelioid mesothelioma in serous effusion. Methods: One hundred and eighty-two cases of serous effusion were collected at Jilin Cancer Hospital, from July 2012 to July 2016. The expression of GLUT1, CDX2, Villin, calretinin and WT1 was evaluated using SP immunocytochemical technique in peritoneal fluid samples collected from 98 patients with gastric cancer and 74 patients with reactive mesothelial cells...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29529095/distinguishing-cell-shoving-mechanisms
#12
Pingyu Nan, Darragh M Walsh, Kerry A Landman, Barry D Hughes
Motivated by in vitro time-lapse images of ovarian cancer spheroids inducing mesothelial cell clearance, the traditional agent-based model of cell migration, based on simple volume exclusion, was extended to include the possibility that a cell seeking to move into an occupied location may push the resident cell, and any cells neighbouring it, out of the way to occupy that location. In traditional discrete models of motile cells with volume exclusion such a move would be aborted. We introduce a new shoving mechanism which allows cells to choose the direction to shove cells that expends the least amount of shoving effort (to account for the likely resistance of cells to being pushed)...
2018: PloS One
https://www.readbyqxmd.com/read/29523930/dna-methylation-profiling-of-asbestos-treated-met5a-cell-line-reveals-novel-pathways-implicated-in-asbestos-response
#13
E Casalone, A Allione, C Viberti, B Pardini, S Guarrera, M Betti, I Dianzani, E Aldieri, G Matullo
Occupational and environmental asbestos exposure is the main determinant of malignant pleural mesothelioma (MPM), however, the mechanisms by which its fibres contribute to cell toxicity and transformation are not completely clear. Aberrant DNA methylation is a common event in cancer but epigenetic modifications involved specifically in MPM carcinogenesis need to be better clarified. To investigate asbestos-induced DNA methylation and gene expression changes, we treated Met5A mesothelial cells with different concentrations of crocidolite and chrysotile asbestos (0...
March 9, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29435293/a-case-of-peritoneal-malignant-mesothelioma-following-radiation-therapy-for-cervical-cancer
#14
Mitsutake Yano, Yuji Ikeda, Tomomi Kato, Mika Sakaki, Sho Sato, Akira Yabuno, Eito Kozawa, Masanori Yasuda
The present study presents a case of peritoneal malignant mesothelioma (PMM) following radiation therapy for cervical cancer. A 34-year-old Japanese woman, without asbestos exposure, was referred to the Department of Gynecologic Oncology, Saitama Medical University International Medical Center due to a cervical mass, and was diagnosed with cervical squamous cell carcinoma (SCC). The serum levels of tumor markers, including SCC antigen and cancer antigen 125 (CA125) were 229.0 ng/ml and 54.4 U/ml, respectively...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29423664/current-management-and-future-opportunities-for-peritoneal-metastases-peritoneal-mesothelioma
#15
H Richard Alexander, Claire Yue Li, Timothy J Kennedy
PURPOSE: Diffuse malignant peritoneal mesothelioma (MPM) is a rare and ultimately fatal cancer that was first described just over a century ago. It is a diffuse malignancy arising from the mesothelial lining of the peritoneum; morbidity and mortality from MPM is due to its propensity to progress locoregionally within the abdominal cavity. METHODS: The purpose of this article is to review the current state-of-the-science related to the diagnosis, staging, and treatment of MPM...
February 8, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29419731/inflammatory-alteration-of-human-t-cells-exposed-continuously-to-asbestos
#16
REVIEW
Naoko Kumagai-Takei, Shoko Yamamoto, Suni Lee, Megumi Maeda, Hidenori Masuzzaki, Nagisa Sada, Min Yu, Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Asbestos is a known carcinogen and exposure can lead to lung cancer and malignant mesothelioma. To examine the effects of asbestos fibers on human immune cells, the human T cell leukemia/lymphoma virus (HTLV)-1 immortalized human T cell line MT-2 was employed. Following continuous exposure to asbestos fibers for more than eight months, MT-2 sublines showed acquisition of resistance to asbestos-induced apoptosis with decreased death signals and increased surviving signals. These sublines showed various characteristics that suggested a reduction in anti-tumor immunity...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29416206/introduction-to-total-mesorectal-excision
#17
Samir Delibegovic
Colorectal cancer is the second leading cause of mortality in the West, and rectal cancer accounts for about 25% of the colon cancers. The concept of total mesothelial excision (TME) was the most important event in surgery for rectal cancer of the last two decades, because even without a curative approach, it reduced local recurrence and extended 5-year survival.
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29362358/therapeutic-potential-of-targeting-s100a11-in-malignant-pleural-mesothelioma
#18
Hiroki Sato, Masakiyo Sakaguchi, Hiromasa Yamamoto, Shuta Tomida, Keisuke Aoe, Kazuhiko Shien, Takahiro Yoshioka, Kei Namba, Hidejiro Torigoe, Junichi Soh, Kazunori Tsukuda, Hiroyuki Tao, Kazunori Okabe, Shinichiro Miyoshi, Harvey I Pass, Shinichi Toyooka
Malignant pleural mesothelioma (MPM) is an aggressive tumor with an unfavorable prognosis. The standard therapeutic approaches are limited to surgery, chemotherapy, and radiotherapy. Because the consequent clinical outcome is often unsatisfactory, a different approach in MPM treatment is required. S100A11, a Ca2+ -binding small protein with two EF-hands, is frequently upregulated in various human cancers. Interestingly, it has been found that intracellular and extracellular S100A11 have different functions in cell viability...
January 24, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29355719/procancerogenic-activity-of-senescent-cells-a-case-of-the-peritoneal-mesothelium
#19
REVIEW
Justyna Mikuła-Pietrasik, Łukasz Stryczyński, Paweł Uruski, Andrzej Tykarski, Krzysztof Książek
Human peritoneal mesothelial cells belong to a narrow group of somatic cells in which both the triggers and the mechanisms of senescence have already been well defined. Importantly, senescent mesothelial cells have been found in the peritoneal cavity in vivo. From a clinical point of view, peritoneal mesothelial cells have been recognized as playing a critical role in the intraperitoneal development of tumor metastases. The pro-cancerogenic behavior of mesothelial cells is even more pronounced when the cells exhaust their proliferative capacity and become senescent...
May 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29348860/silencing-ror1-and-ror2-inhibits-invasion-and-adhesion-in-an-organotypic-model-of-ovarian-cancer-metastasis
#20
Claire Henry, Neville Hacker, Caroline Ford
OBJECTIVE: Elevated expression of the ROR1 and ROR2 Wnt receptors has been noted in both the tumour and stromal compartments of ovarian cancer patient tissue samples. In vitro studies have suggested these receptors play a role in ovarian cancer metastasis. However, these previous studies have utilised simple 2D in vitro models to investigate cancer cell growth and migration, which does not allow investigation of stromal involvement in Wnt driven metastasis. AIM: To investigate targeting ROR1 and ROR2 using a primary co-culture 3D model of epithelial ovarian cancer dissemination to the omentum...
December 22, 2017: Oncotarget
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