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https://www.readbyqxmd.com/read/29278633/tumor-marker-ca-125-in-the-diagnosis-of-active-pulmonary-tuberculosis-a-study-of-adults-in-mostar-b-h
#1
Marijana Mikačić, Ivan Vasilj, Marina Vasilj, Danijel Bevanda, Mario Šimović, Kristina Galić
BACKGROUND: Tumor marker CA 125 is found in normal mesothelial lung cells and normal bronchial epithelial cells. If destruction of these cells occurs due to inflammation or tumour, CA 125 will be released, and increased in the serum. SUBJECTS AND METHODS: From November 2008 to May 2009 a study analysing CA 125 levels in serum samples from patients who are hospitalized at the Pulmology Department of University Hospital Mostar. Standard laboratory tests, X-ray, sputum examination to BK, and tumour marker CA 125 were performed in all patients...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29241971/blocking-stemness-and-metastatic-properties-of-ovarian-cancer-cells-by-targeting-p70s6k-with-dendrimer-nanovector-based-sirna-delivery
#2
Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, Yifan Jiang, Xiaoxuan Liu, Suzanne Giorgio, Ling Peng, Alice S T Wong
Metastasis is the cause of most (>90%) cancer deaths and currently lacks effective treatments. Approaches to understanding the biological process, unraveling the most effective molecular target(s), and implementing nanotechnology to increase the therapeutic index are expected to facilitate cancer therapy against metastasis. Here, we demonstrate the potential advantages of bringing these three approaches together through the rational design of a small interfering RNA (siRNA) that targets p70S6K in cancer stem cells (CSCs) in combination with dendrimer nanotechnology-based siRNA delivery...
November 16, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29241375/peritoneal-dissemination-of-ovarian-cancer-role-of-muc16-mesothelin-interaction-and-implications-for-treatment
#3
Ricardo Coelho, Lara Marcos-Silva, Sara Ricardo, Filipa Ponte, Antonia Costa, Jose Manuel Lopes, Leonor David
Peritoneal dissemination is a particular form of malignant progression in ovarian cancer, preceding hematogenic or lymphatic dissemination. Thus, prevention of peritoneal implantation of cancer cells is envisioned to inhibit neoplastic dissemination and therefore prolong disease remission and patient's survival. Areas covered: An extended review on the role of MUC16 (CA125) and mesothelin (MSLN), expressed in a high percentage of ovarian carcinomas, indicate that this duet is relevant for the contact between cancer cells and mesothelial cells in homotypic (cancer cell-cancer cell) and heterotypic (cancer cell-mesothelial cell) interactions...
December 14, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29228689/gremlin-1-is-a-key-regulator-of-the-invasive-cell-phenotype-in-mesothelioma
#4
Miao Yin, Mira Tissari, Jenni Tamminen, Irene Ylivinkka, Mikko Rönty, Pernilla von Nandelstadh, Kaisa Lehti, Marko Hyytiäinen, Marjukka Myllärniemi, Katri Koli
Malignant mesothelioma originates from mesothelial cells and is a cancer type that aggressively invades into the surrounding tissue, has poor prognosis and no effective treatment. Gremlin-1 is a cysteine knot protein that functions by inhibiting BMP-pathway activity during development. BMP-independent functions have also been described for gremlin-1. We have previously shown high gremlin-1 expression in mesothelioma tumor tissue. Here, we investigated the functions of gremlin-1 in mesothelioma cell migration and invasive growth...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29193022/experimental-study-of-delivery-of-humidified-warm-carbon-dioxide-during-open-abdominal-surgery
#5
S Carpinteri, S Sampurno, J Malaterre, R Millen, M Dean, J Kong, T Chittleborough, A Heriot, A C Lynch, R G Ramsay
BACKGROUND: The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO2 ) delivered into the open abdomen of mice, simulating laparotomy. METHODS: Mice were anaesthetized, ventilated and subjected to an abdominal incision followed by wound retraction. In the experimental group, a diffuser device was used to deliver HWCO2 ; the control group was exposed to passive air flow. In each group of mice, surgical damage was produced on one side of the peritoneal wall...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29192324/a-novel-mechanism-of-neovascularization-in-peritoneal-dissemination-via-cancer-associated-mesothelial-cells-affected-by-tgf-%C3%AE-derived-from-ovarian-cancer
#6
Kayo Fujikake, Hiroaki Kajiyama, Masato Yoshihara, Kimihiro Nishino, Nobuhisa Yoshikawa, Fumi Utsumi, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Hiroko Mitsui, Kiyosumi Shibata, Takeshi Senga, Fumitaka Kikkawa
Epithelial ovarian cancer (EOC) is believed to cause peritoneum dissemination through microenvironmental cell‑to-cell communication between the tumor and mesothelium, leading to the further acquisition of progressive and metastatic potentials. In the present study, we aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the promotion of tumor neovascularization and vascular permeability via enhanced vascular endothelial growth factor (VEGF) production. We examined whether a characteristic morphological change in human peritoneal mesothelial cells (HPMCs) was observed in the presence of malignant ascites and tumor-derived TGF-β...
January 2018: Oncology Reports
https://www.readbyqxmd.com/read/29174800/ets1-induction-by-the-microenvironment-promotes-ovarian-cancer-metastasis-through-focal-adhesion-kinase
#7
Sunil Tomar, Joshua P Plotnik, James Haley, Joshua Scantland, Subramanyam Dasari, Zahir Sheikh, Robert Emerson, Dean Lenz, Peter C Hollenhorst, Anirban K Mitra
Metastatic colonization involves paracrine/juxtacrine interactions with the microenvironment inducing an adaptive response through transcriptional regulation. However, the identities of transcription factors (TFs) induced by the metastatic microenvironment in ovarian cancer (OC) and their mechanism of action is poorly understood. Using an organotypic 3D culture model recapitulating the early events of metastasis, we identified ETS1 as the most upregulated member of the ETS family of TFs in metastasizing OC cells as they interacted with the microenvironment...
November 21, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29164988/development-of-peritoneal-carcinomatosis-in-epithelial-ovarian-cancer-a-review
#8
Juliette O A M van Baal, Cornelis J F van Noorden, Rienk Nieuwland, Koen K Van de Vijver, Auguste Sturk, Willemien J van Driel, Gemma G Kenter, Christianne A R Lok
Epithelial ovarian cancer (EOC) metastasizes intra-abdominally with often numerous, superficial, small-sized lesions. This so-called peritoneal carcinomatosis is difficult to treat, and peritoneal recurrences are frequently observed, leading to a poor prognosis. Underlying mechanisms of interactions between EOC and peritoneal cells are incompletely understood. This review summarizes and discusses the development of peritoneal carcinomatosis from a cell-biological perspective, focusing on characteristics of EOC and peritoneal cells...
November 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29118473/validating-micronucleus-score-in-effusion-fluids
#9
Nidhya Ganesan, Manjiri D Phansalkar, Marie M Ambroise, Renu G Varghese
Background: Identifying malignant cells in effusion fluid is vital in staging and management of cancers. Differentiating reactive mesothelial cells from malignant cells in effusion fluid is a challenging task and there is an ongoing need for simpler and cost effective tool to aid the diagnosis. Micronucleus is an additional smaller nucleus in the cytoplasm, formed by chromosomes or chromosomal fragments formed during cell division. Aims: The aim of this study was to assess the significance of micronucleated cell in effusion fluids to distinguish adenocarcinomatous from reactive mesothelial effusions...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29116477/4egi-1-represses-cap-dependent-translation-and-regulates-genome-wide-translation-in-malignant-pleural-mesothelioma
#10
Arpita De, Blake A Jacobson, Mark S Peterson, Joe Jay-Dixon, Marian G Kratzke, Ahad A Sadiq, Manish R Patel, Robert A Kratzke
Deregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F (eIF4F) complex. The effects of 4EGI-1-mediated inhibition of translation initiation in malignant pleural mesothelioma (MPM) were examined. 4EGI-1 preferentially inhibited cell viability and induced apoptosis in MPM cells compared to normal mesothelial (LP9) cells...
November 8, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29100460/targeting-microrna-to-improve-diagnostic-and-therapeutic-approaches-for-malignant-mesothelioma
#11
REVIEW
Kimberly A Birnie, Cecilia M Prêle, Philip J Thompson, Bahareh Badrian, Steven E Mutsaers
Malignant mesothelioma is an aggressive and often fatal cancer associated with asbestos exposure. The disease originates in the mesothelial lining of the serosal cavities, most commonly affecting the pleura. Survival rates are low as diagnosis often occurs at an advanced stage and current treatments are limited. Identifying new diagnostic and therapeutic targets for mesothelioma remains a priority, particularly for the new wave of victims exposed to asbestos through do-it-yourself renovations and in countries where asbestos is still mined and used...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29080447/epidemiology-of-malignant-peritoneal-mesothelioma-a-population-based-study
#12
Silja A S Salo, Ilkka Ilonen, Sanna Laaksonen, Marjukka Myllärniemi, Jarmo A Salo, Tuomo Rantanen
BACKGROUND: Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the mesothelial cells in the peritoneum with poor prognosis. Earlier reports from other countries indicate an incidence of 0.2-3 new cases per million per year. No previous studies have examined the national epidemiology of MPeM in Nordic countries. This study aimed to clarify the epidemiology of MPeM in Finland over a 12-year period. METHODS: The data consisted of cancer notifications, laboratory notifications, and death certificate information in the Finnish Cancer Registry (FCR) and Statistics Finland (SF) of all MPeM patients from 2000 to 2012 in Finland...
October 25, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29076043/locally-advanced-colorectal-cancer-true-peritoneal-tumor-penetration-is-associated-with-peritoneal-metastases
#13
Charlotte E L Klaver, Nadine C M van Huijgevoort, Anthony de Buck van Overstraeten, Albert M Wolthuis, Pieter J Tanis, Jarmila D W van der Bilt, Xavier Sagaert, André D'Hoore
BACKGROUND: Findings show T4 colorectal cancer (CRC) to be a risk factor for the development of peritoneal metastases (PM). Heterogeneity regarding peritoneal involvement of T4 tumors might explain the wide range of reported PM incidences (8-50%). Hyperplastic and mesothelial inflammatory reactions complicate evaluation of the exact primary tumor involvement of the peritoneal layer. This retrospective cohort study aimed to assess the association between either inflammatory peritoneal reaction or peritoneal involvement of the primary tumor and the risk of PM...
October 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29059207/targeting-mesothelin-receptors-with-drug-loaded-bacterial-nanocells-suppresses-human-mesothelioma-tumour-growth-in-mouse-xenograft-models
#14
Mohamed A Alfaleh, Christopher B Howard, Ilya Sedliarou, Martina L Jones, Reema Gudhka, Natasha Vanegas, Jocelyn Weiss, Julia H Suurbach, Christopher J de Bakker, Michael R Milne, Bree A Rumballe, Jennifer A MacDiarmid, Himanshu Brahmbhatt, Stephen M Mahler
Human malignant mesothelioma is a chemoresistant tumour that develops from mesothelial cells, commonly associated with asbestos exposure. Malignant mesothelioma incidence rates in European countries are still rising and Australia has one of the highest burdens of malignant mesothelioma on a population basis in the world. Therapy using systemic delivery of free cytotoxic agents is associated with many undesirable side effects due to non-selectivity, and is thus dose-limited which limits its therapeutic potential...
2017: PloS One
https://www.readbyqxmd.com/read/29058958/annals-express-biomarkers-in-mesothelioma
#15
David T Arnold, Nick Maskell
Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently there has been interest in the ability of serum/plasma biomarkers to monitor mesothelioma, given development of newer treatments, and limitations of radiological assessment. The majority of research has focused on soluble mesothelin (SM), a soluble glycoprotein expressed by mesothelial cells...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29053210/a-combination-of-mtap-and-bap1-immunohistochemistry-in-pleural-effusion-cytology-for-the-diagnosis-of-mesothelioma
#16
Yoshiaki Kinoshita, Tomoyuki Hida, Makoto Hamasaki, Shinji Matsumoto, Ayuko Sato, Tohru Tsujimura, Kunimitsu Kawahara, Kenzo Hiroshima, Yoshinao Oda, Kazuki Nabeshima
BACKGROUND: Homozygous deletion of 9p21 detected by fluorescence in situ hybridization (FISH) and loss of BRCA1-associated protein 1 (BAP1) expression detected by immunohistochemistry (IHC) are useful for the differentiation between malignant pleural mesothelioma (MPM) and reactive mesothelial hyperplasia. The authors previously described that IHC expression of the protein product of the methylthioadenosine phosphorylase (MTAP) gene, which is localized in the 9p21 chromosomal region, was correlated with the deletion status of 9p21 FISH in MPM tissues...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29032203/construction-of-artificial-human-peritoneal-tissue-by-cell-accumulation-technique-and-its-application-for-visualizing-morphological-dynamics-of-cancer-peritoneal-metastasis
#17
Yoshiya Asano, Tadashi Odagiri, Hiroe Oikiri, Michiya Matsusaki, Mitsuru Akashi, Hiroshi Shimoda
Human peritoneum is composed of mesothelial monolayer and stromal tissue containing microvasculature. Dissemination and infiltration of cancer cells to the peritoneum result in cancer peritoneal metastasis which is an important prognostic factor of intraperitoneal or intrapelvic carcinoma. To elucidate an initial metastatic mechanism of cancer cells, in vitro human peritoneal models are demanded. In this study, we created a three-dimensional artificial human peritoneal tissue (AHPT) harboring the blood or lymphatic vascular network by cell-accumulation technique...
October 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28956065/the-peritoneal-soil-for-a-cancerous-seed-a-comprehensive-review-of-the-pathogenesis-of-intraperitoneal-cancer-metastases
#18
REVIEW
Justyna Mikuła-Pietrasik, Paweł Uruski, Andrzej Tykarski, Krzysztof Książek
Various types of tumors, particularly those originating from the ovary and gastrointestinal tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The intraperitoneal spread of a malignancy is orchestrated by a reciprocal interplay between invading cancer cells and resident normal peritoneal cells. In this review, we address the current state-of-art regarding colonization of the peritoneal cavity by ovarian, colorectal, pancreatic, and gastric tumors. Particular attention is paid to the pro-tumoral role of various kinds of peritoneal cells, including mesothelial cells, fibroblasts, adipocytes, macrophages, the vascular endothelium, and hospicells...
February 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28943926/combination-of-galectin-3-ck19-and-hbme-1-immunostaining-improves-the-diagnosis-of-thyroid-cancer
#19
Vanessa Arcolia, Fabrice Journe, Florence Renaud, Emmanuelle Leteurtre, Hans-Joachim Gabius, Myriam Remmelink, Sven Saussez
Currently, fine-needle aspiration is the most frequently used pre-operative technique for diagnosis of malignant thyroid tumors, however, pathologists are unable to reach efficient and accurate differential diagnoses between benign and malignant thyroid nodules. To aid in resolving this issue, immunohistochemistry for galectins (gal)-1, -3, -7, -8, cytokeratin 19 (CK19), Hector Battifora Mesothelial Epitope-1 (HBME-1) and thyroid peroxidase (TPO) was performed on two tissue microarrays composed of 66 follicular adenomas (FA) and 66 papillary carcinomas (PC)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28929108/different-cellular-response-of-human-mesothelial-cell-met-5a-to-short-term-and-long-term-multiwalled-carbon-nanotubes-exposure
#20
Li Ju, Wei Wu, Min Yu, Jianlin Lou, Hao Wu, Xianhong Yin, Zhenyu Jia, Yun Xiao, Lijin Zhu, Jun Yang
Despite being a commercially important product, multiwalled carbon nanotubes (MWCNTs) continue to raise concerns over human health due to their structural similarity to asbestos. Indeed, exposure to MWCNT has been shown to induce lung cancer and even mesothelioma, but contradictory results also exist. To clarify the potentially carcinogenic effects of rigid and rod-like MWCNT and to elucidate the underlying mechanisms, the effects of MWCNT on human mesothelial cell MeT-5A were examined throughout 3 months of continuous exposure, including cytotoxicity, genotoxicity, and cell motility...
2017: BioMed Research International
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