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Phage Cocktail

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https://www.readbyqxmd.com/read/28757045/efficacy-of-potential-phage-cocktails-against-vibrio-harveyi-and-closely-related-vibrio-species-isolated-from-shrimp-aquaculture-environment-in-the-south-east-coast-of-india
#1
Nattan Stalin, Pappu Srinivasan
A diverse set of novel phages infecting the marine pathogenic Vibrio harveyi was isolated from shrimp aquaculture environments in the south east coast of India. Based on initial screening, three phages with a broad host range revealed that the growth inhibition of phage is relatively specific to V. harveyi. They were also able to infect V. alginolyticus and V. parahemolyticus that belonged to the Harveyi clade species from shrimp pond and sea coast environment samples. However, the impact of these phages on their host bacterium are well understood; a one-step growth curve experiment and transmission electron microscope (TEM) revealed three phages grouped under the Myoviridae (VHM1 and VHM2); Siphoviridae (VHS1) family...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28742812/broad-range-lytic-bacteriophages-that-kill-staphylococcus-aureus-local-field-strains
#2
Virginia Abatángelo, Natalia Peressutti Bacci, Carina A Boncompain, Ariel A Amadio, Soledad Carrasco, Cristian A Suárez, Héctor R Morbidoni
Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic bacteriophages that kill bacteria in a genus -or even species- specific way, has become an attractive field of study...
2017: PloS One
https://www.readbyqxmd.com/read/28739792/transfersomal-phage-cocktail-an-effective-treatment-against-methicillin-resistant-s-aureus-mrsa-mediated-skin-and-soft-tissue-infections-sstis
#3
Sanjay Chhibber, Ashu Shukla, Sandeep Kaur
Emergence of drug resistance has rekindled the interest in phage therapy as an alternative treatment option. Its potency, safety and proven efficacy is worth noting. However, phage therapy still suffers from issues of poor stability, narrow spectrum and poor pharmacokinetic profile. It therefore becomes essential to look into the use of Drug Delivery Systems (DDS) for efficient delivery of lytic phages in vivo For the first time, the present study has evaluated the use of nano-structured lipid based carriers i...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28719657/isolation-and-in-vitro-evaluation-of-bacteriophages-against-mdr-bacterial-isolates-from-septic-wound-infections
#4
Roja Rani Pallavali, Vijaya Lakshmi Degati, Dakshayani Lomada, Madhava C Reddy, Vijaya Raghava Prasad Durbaka
Multi-drug resistance has become a major problem for the treatment of pathogenic bacterial infections. The use of bacteriophages is an attractive approach to overcome the problem of drug resistance in several pathogens that cause fatal diseases. Our study aimed to isolate multi drug resistant bacteria from patients with septic wounds and then isolate and apply bacteriophages in vitro as alternative therapeutic agents. Pus samples were aseptically collected from Rajiv Gandhi Institute of Medical Science (RIMS), Kadapa, A...
2017: PloS One
https://www.readbyqxmd.com/read/28700707/environmental-bacteriophages-active-on-biofilms-and-planktonic-forms-of-toxigenic-vibrio-cholerae-potential-relevance-in-cholera-epidemiology
#5
Iftekhar Bin Naser, M Mozammel Hoque, Ahmed Abdullah, S M Nayeemul Bari, Amar N Ghosh, Shah M Faruque
METHODS: Phages isolated from environmental waters in Bangladesh were tested for their host specificity towards V. cholerae O1 and O139, and the ability to disperse V. cholerae biofilms formed in the laboratory. Representative phages were further characterized by electron microscopy and whole genome sequencing. Selected phages were then introduced in various combinations to biofilms of toxigenic V. cholerae added to samples of river water, and the dispersion of biofilms as well as the growth kinetics of V...
2017: PloS One
https://www.readbyqxmd.com/read/28688779/formulation-stabilisation-and-encapsulation-of-bacteriophage-for-phage-therapy
#6
REVIEW
Danish J Malik, Ilya J Sokolov, Gurinder K Vinner, Francesco Mancuso, Salvatore Cinquerrui, Goran T Vladisavljevic, Martha R J Clokie, Natalie J Garton, Andrew G F Stapley, Anna Kirpichnikova
Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurgent interest in the potential use of bacteriophages for therapeutic purposes, known as phage therapy. A number of phage therapy phase I and II clinical trials have concluded, and shown phages don't present significant adverse safety concerns. These clinical trials used simple phage suspensions without any formulation and phage stability was of secondary concern. Phages have a limited stability in solution, and undergo a significant drop in phage titre during processing and storage which is unacceptable if phages are to become regulated pharmaceuticals, where stable dosage and well defined pharmacokinetics and pharmacodynamics are de rigueur...
May 14, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28664828/phage-therapy-approaches-to-reducing-pathogen-persistence-and-transmission-in-animal-production-environments-opportunities-and-challenges
#7
Anna Colavecchio, Lawrence D Goodridge
The era of genomics has allowed for characterization of phages for use as antimicrobials to treat animal infections with a level of precision never before realized. As more research in phage therapy has been conducted, several advantages of phage therapy have been realized, including the ubiquitous nature, specificity, prevalence in the biosphere, and low inherent toxicity of phages, which makes them a safe and sustainable technology for control of animal diseases. These unique qualities of phages have led to several opportunities with respect to emerging trends in infectious disease treatment...
June 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28576360/characterization-of-antimicrobial-properties-of-salmonella-phage-felix-o1-and-listeria-phage-a511-embedded-in-xanthan-coatings-on-poly-lactic-acid-films
#8
Devon Radford, Brandon Guild, Philip Strange, Rafath Ahmed, Loong-Tak Lim, S Balamurugan
Beyond simply providing a barrier between food and external contaminants, active packaging technologies aim to inhibit pathogen survival and growth within the packaged environment. Bacteriophages have a proven track record as targeted antimicrobials but have yet to be successfully integrated in active packaging without serious loss of activity. We have developed two bacteriophage based xanthan coatings on poly(lactic acid) (PLA) film which significantly inhibits Salmonella Typhimurium and Listeria monocytogenes growth in culture (P < 0...
September 2017: Food Microbiology
https://www.readbyqxmd.com/read/28515656/isolation-and-characterization-of-listeria-phages-for-control-of-growth-of-listeria-monocytogenes-in-milk
#9
Sunhee Lee, Min Gon Kim, Hee Soo Lee, Sunhak Heo, Mirae Kwon, GeunBae Kim
In this study, two Listeria bacteriophages, LMP1 and LMP7, were isolated from chicken feces as a means of biocontrol of L. monocytogenes. Both bacteriophages had a lytic effect on L. monocytogenes ATCC 7644, 15313, 19114, and 19115. Phages LMP1 and LMP7 were able to inhibit the growth of L. monocytogenes ATCC 7644 and 19114 in tryptic soy broth at 10°C and 30°C. Nevertheless, LMP1 was more effective than LMP7 at inhibiting L. monocytogenes ATCC 19114. On the contrary, LMP7 was more effective than LMP1 at inhibiting L...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28502784/liposome-loaded-phage-cocktail-enhanced-therapeutic-potential-in-resolving-klebsiella-pneumoniae-mediated-burn-wound-infections
#10
Parul Chadha, Om Prakash Katare, Sanjay Chhibber
BACKGROUND: Klebsiella pneumoniae is one of the predominant pathogens in burn wound infections, and prevalence of multidrug resistant strains has further complicated the situation. An increased interest in phage therapy as a means of combating infection has been accruing in recent years. In order to overcome the drawbacks associated with phage therapy, the present study was conducted to evaluate the potential of liposomes as a delivery vehicle for phage in the treatment of burn wound infection...
May 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28460269/investigating-the-biocontrol-and-anti-biofilm-potential-of-a-three-phage-cocktail-against-cronobacter-sakazakii-in-different-brands-of-infant-formula
#11
Lorraine Endersen, Colin Buttimer, Eoghan Nevin, Aidan Coffey, Horst Neve, Hugo Oliveira, Rob Lavigne, Jim O'Mahony
In recent years, the microbiological safety of powdered infant formula has gained increasing attention due to the identification of contaminating C. sakazakii and its epidemiological link with life-threatening neonatal infections. Current intervention strategies have fallen short of ensuring the production of infant formula that is free from C. sakazakii. In this study, we describe the isolation and characterisation of three bacteriophages (phages) and their application as a phage cocktail to inhibit the growth of C...
April 21, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28405193/the-efficacy-of-isolated-bacteriophages-from-pig-farms-against-esbl-ampc-producing-escherichia-coli-from-pig-and-turkey-farms
#12
Aneta Skaradzińska, Paulina Śliwka, Marta Kuźmińska-Bajor, Grzegorz Skaradziński, Anna Rząsa, Anika Friese, Nicole Roschanski, Jayaseelan Murugaiyan, Uwe H Roesler
Extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases are plasmid (but also chromosomally) encoded enzymes found in Enterobacteriaceae, determining resistance to a variety of important antibiotics including penicillins, cephalosporins, and monobactams. In recent decades, the prevalence of ESBL/AmpC-producing bacteria has increased rapidly across the world. Here, we evaluate the potential use of bacteriophages in terms of a reduction of antibiotic-resistant bacteria in healthy animals. The aim of our studies was to isolate bacteriophages capable of destroying ESBL/AmpC-producing Escherichia coli isolated from livestock habitats...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28387353/characterization-and-genomic-analyses-of-two-newly-isolated-morganella-phages-define-distant-members-among-tevenvirinae-and-autographivirinae-subfamilies
#13
Hugo Oliveira, Graça Pinto, Ana Oliveira, Jean-Paul Noben, Hanne Hendrix, Rob Lavigne, Małgorzata Łobocka, Andrew M Kropinski, Joana Azeredo
Morganella morganii is a common but frequent neglected environmental opportunistic pathogen which can cause deadly nosocomial infections. The increased number of multidrug-resistant M. morganii isolates motivates the search for alternative and effective antibacterials. We have isolated two novel obligatorily lytic M. morganii bacteriophages (vB_MmoM_MP1, vB_MmoP_MP2) and characterized them with respect to specificity, morphology, genome organization and phylogenetic relationships. MP1's dsDNA genome consists of 163,095 bp and encodes 271 proteins, exhibiting low DNA (<40%) and protein (<70%) homology to other members of the Tevenvirinae...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362863/bacteriophage-preparation-lytic-for-shigella-significantly-reduces-shigella-sonnei-contamination-in-various-foods
#14
Nitzan Soffer, Joelle Woolston, Manrong Li, Chythanya Das, Alexander Sulakvelidze
ShigaShield™ is a phage preparation composed of five lytic bacteriophages that specifically target pathogenic Shigella species found in contaminated waters and foods. In this study, we examined the efficacy of various doses (9x105-9x107 PFU/g) of ShigaShield™ in removing experimentally added Shigella on deli meat, smoked salmon, pre-cooked chicken, lettuce, melon and yogurt. The highest dose (2x107 or 9x107 PFU/g) of ShigaShield™ applied to each food type resulted in at least 1 log (90%) reduction of Shigella in all the food types...
2017: PloS One
https://www.readbyqxmd.com/read/28286740/long-term-safety-of-topical-bacteriophage-application-to-the-frontal-sinus-region
#15
Amanda J Drilling, Mian L Ooi, Dijana Miljkovic, Craig James, Peter Speck, Sarah Vreugde, Jason Clark, Peter-John Wormald
Background:Staphylococcus aureus biofilms contribute negatively to a number of chronic conditions, including chronic rhinosinusitis (CRS). With the inherent tolerance of biofilm-bound bacteria to antibiotics and the global problem of bacterial antibiotic resistance, the need to develop novel therapeutics is paramount. Phage therapy has previously shown promise in treating sinonasal S. aureus biofilms. Methods: This study investigates the long term (20 days) safety of topical sinonasal flushes with bacteriophage suspensions...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28163700/bacteriophages-and-bacterial-plant-diseases
#16
REVIEW
Colin Buttimer, Olivia McAuliffe, R P Ross, Colin Hill, Jim O'Mahony, Aidan Coffey
Losses in crop yields due to disease need to be reduced in order to meet increasing global food demands associated with growth in the human population. There is a well-recognized need to develop new environmentally friendly control strategies to combat bacterial crop disease. Current control measures involving the use of traditional chemicals or antibiotics are losing their efficacy due to the natural development of bacterial resistance to these agents. In addition, there is an increasing awareness that their use is environmentally unfriendly...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28146150/a-cocktail-of-three-virulent-bacteriophages-prevents-vibrio-cholerae-infection-in-animal-models
#17
Minmin Yen, Lynne S Cairns, Andrew Camilli
Effective prevention strategies will be essential in reducing disease burden due to bacterial infections. Here we harness the specificity and rapid-acting properties of bacteriophages as a potential prophylaxis therapy for cholera, a severely dehydrating disease caused by Vibrio cholerae. To this end, we test a cocktail of three virulent phages in two animal models of cholera pathogenesis (infant mouse and rabbit models). Oral administration of the phages up to 24 h before V. cholerae challenge reduces colonization of the intestinal tract and prevents cholera-like diarrhea...
February 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28120922/microencapsulation-with-alginate-caco3-a-strategy-for-improved-phage-therapy
#18
Joan Colom, Mary Cano-Sarabia, Jennifer Otero, Javier Aríñez-Soriano, Pilar Cortés, Daniel Maspoch, Montserrat Llagostera
Bacteriophages are promising therapeutic agents that can be applied to different stages of the commercial food chain. In this sense, bacteriophages can be orally administered to farm animals to protect them against intestinal pathogens. However, the low pH of the stomach, the activities of bile and intestinal tract enzymes limit the efficacy of the phages. This study demonstrates the utility of an alginate/CaCO3 encapsulation method suitable for bacteriophages with different morphologies and to yield encapsulation efficacies of ~100%...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28007922/synergistic-interaction-between-phage-therapy-and-antibiotics-clears-pseudomonas-aeruginosa-infection-in-endocarditis-and-reduces-virulence
#19
Frank Oechslin, Philippe Piccardi, Stefano Mancini, Jérôme Gabard, Philippe Moreillon, José M Entenza, Gregory Resch, Yok-Ai Que
Background.: Increasing antibiotic resistance warrants therapeutic alternatives. Here we investigated the efficacy of bacteriophage-therapy (phage) alone or combined with antibiotics against experimental endocarditis (EE) due to Pseudomonas aeruginosa, an archetype of difficult-to-treat infection. Methods.: In vitro fibrin clots and rats with aortic EE were treated with an antipseudomonas phage cocktail alone or combined with ciprofloxacin. Phage pharmacology, therapeutic efficacy, and resistance were determined...
March 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27932642/complete-genome-sequence-of-vb_ecom-ufv13-a-new-bacteriophage-able-to-disrupt-trueperella-pyogenes-biofilm
#20
Vinícius S Duarte, Roberto S Dias, Andrew M Kropinski, Pedro M P Vidigal, Flávia O Sousa, André S Xavier, Cynthia C Silva, Sergio O de Paula
vB_EcoM-UFV13, a member of the T4virus genus, shows lytic activity against Escherichia coli and effectiveness in controlling the biofilm formed by Trueperella pyogenes, which qualifies it as a promising component of phage cocktails for mastitis and metritis control.
December 8, 2016: Genome Announcements
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