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https://www.readbyqxmd.com/read/28320158/addressing-post-stroke-care-in-rural-areas-with-peru-as-a-case-study-placing-emphasis-on-evidence-based-pragmatism
#1
REVIEW
J Jaime Miranda, Miguel G Moscoso, Lijing L Yan, Francisco Diez-Canseco, Germán Málaga, Hector H Garcia, Bruce Ovbiagele
Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family caregivers in these regions lack the necessary knowledge to assist them. Intriguingly, a recent rapid growth in cell-phone use and digital technology in rural areas has not yet been appropriately exploited for health care training and delivery purposes. What should be done in rural areas, at the community setting-level, where access to healthcare is limited remains a challenge...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320152/electrographic-patterns-in-patients-with-posterior-reversible-encephalopathy-syndrome-and-seizures
#2
Carlos Kamiya-Matsuoka, Sudhakar Tummala
INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state associated with reversible cerebral vasogenic edema. Seizures are a common clinical presentation in PRES, however its electroencephalographic and radiologic pattern correlation is limited in this subset of patients. The aim of this study is to analyze the origin of electrographic dysfunction according to the radiologic pattern in patients with PRES and seizures. METHODS: We retrospectively identified 46 cancer patients who developed PRES and seizures at The University of Texas MD Anderson Cancer Center between January 2006 and June 2012...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320044/multiple-concomitant-oral-cavity-cancers-incidence-management-and-outcomes
#3
Huang-Kai Kao, Mohamed Abdelrahman, Yenlin Huang, Chia-Hsuan Tsai, Megias J Barrera, Ngan-Ming Tsang, Adam J Couves, Ming-Huei Cheng, Kai-Ping Chang
BACKGROUND: Little is known about the appropriate treatment and long-term survival of patients with multiple concomitant oral cavity cancers (MOC). The aim of this study was to clarify the clinicopathological features of MOC, to compare the prognosis of MOC patients with that of patients with single oral cavity cancers (SOC), and to describe reconstructive options based on the concept of economy in autologous tissue transfer. METHODS: Data from 603 patients diagnosed with at least one squamous cell carcinoma of the oral cavity who underwent surgery for primary oral cavity cancers between 2006 and 2014 were reviewed retrospectively to identify MOC patients...
March 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28320029/morphometric-changes-of-the-lumbar-intervertebral-foramen-after-percutaneous-endoscopic-foraminoplasty-under-local-anesthesia
#4
Tatsuhiko Henmi, Tomoya Terai, Akihiro Nagamachi, Koichi Sairyo
Background Percutaneous endoscopic diskectomy (PED) for the lumbar spine is a relatively new technique that is becoming more common due to its relatively less invasive nature. However, one possible serious complication is an exiting nerve injury when the cannula of the endoscope is inserted into the neural canal through the intervertebral foramen. A technique to enlarge the intervertebral foramen, called foraminoplasty, was recently established to insert the cannula safely into an appropriate position in the neural canal...
March 20, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28320026/-alcohol-withdrawal-and-its-major-complications
#5
Klaus Junghanns, Tilman Wetterling
Delirium tremens is one of the most common complications of alcohol withdrawal. It is potentially lethal and therefore should be detected as early as possible and be monitored and treated intensively. The assessment of risk factors with the Luebeck Alcohol-Withdrawal Risk Scale short form (LARS-11) can help to predict the risk of severe withdrawal adequately. As delirium cannot be differentiated from Wernicke-Encephalopathy with sufficient certainty high parenteral doses of Vitamin B1 and Magnesium orally should be given in case of any severe withdrawal symptoms...
March 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28319866/contrast-enhanced-ultrasound-and-computed-tomography-findings-of-granulomatosis-with-polyangiitis-presenting-with-multiple-intrarenal-microaneurysms-a-case-report
#6
Youe Ree Kim, Young Hwan Lee, Jong-Ho Lee, Kwon-Ha Yoon
Granulomatosis with polyangiitis (GPA) is a systemic disorder that affects small- and medium- sized vessels in many organs. Although the kidneys are the second most commonly involved organ in patients with GPA, its manifestation as multiple intrarenal aneurysms is rare. We report an unusual manifestation of GPA with multiple intrarenal microaneurysms, as demonstrated by contrast-enhanced ultrasound and computed tomography.
March 9, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28319801/first-trimester-prediction-of-gestational-diabetes-mellitus-a-clinical-model-based-on-maternal-demographic-parameters
#7
Arianne N Sweeting, Heidi Appelblom, Glynis P Ross, Jencia Wong, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
AIM: Develop a first trimester risk prediction model for GDM based on maternal clinical characteristics in a large metropolitan multi-ethnic population and compare its performance to that of other recently published GDM prediction models and clinical risk scoring systems. METHODS: A retrospective case control study of 248 women who developed GDM and 732 controls who did not. Maternal clinical parameters were prospectively obtained at 11-13(+6) weeks' gestation. A predictive multivariate regression model for GDM was developed, evaluated using areas under the receiver-operating characteristic (AUC) curve...
March 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28319747/integration-of-in-silico-methods-and-computational-systems-biology-to-explore-endocrine-disrupting-chemical-binding-with-nuclear-hormone-receptors
#8
P Ruiz, A Sack, M Wampole, S Bobst, M Vracko
Thousands of potential endocrine-disrupting chemicals present difficult regulatory challenges. Endocrine-disrupting chemicals can interfere with several nuclear hormone receptors associated with a variety of adverse health effects. The U.S. Environmental Protection Agency (U.S. EPA) has released its reviews of Tier 1 screening assay results for a set of pesticides in the Endocrine Disruptor Screening Program (EDSP), and recently, the Collaborative Estrogen Receptor Activity Prediction Project (CERAPP) data...
March 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319579/vulvar-carcinosarcoma-composed-of-intestinal-type-mucinous-adenocarcinoma-associated-with-anaplastic-pleomorphic-and-spindle-cell-carcinoma-and-heterologous-chondrosarcomatous-and-osteosarcomatous-elements-a-case-report-and-review-of-the-literature
#9
Leonardo Lordello, Patricia Webb, Esther Oliva
Carcinosarcomas (CS) are exceedingly rare in the vulva, with only 3 cases reported in the English literature, associated with squamous cell carcinoma (2) or spiradenocarcinoma (1). We first report a vulvar CS with intestinal-type mucinous adenocarcinoma associated with anaplastic pleomorphic and spindle cell carcinoma and heterologous chondro- and osteosarcomatous elements in a 62-year-old woman, who presented with a painless, slow-growing vulvar cyst for almost 2 years, that rapidly enlarged and hardened in the last 4 months forming a mass...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319574/melf-pattern-for-predicting-lymph-node-involvement-and-survival-in-grade-i-ii-endometrioid-type-endometrium-cancer
#10
Muzaffer Sanci, Kemal Güngördük, Varol Gülseren, Tuğba Karadeniz, Mustafa Kocaer, Ozgu Gungorduk, İsa A Özdemir
The aim of this study was to examine the associations between microcystic, elongated, and fragmented (MELF) pattern and other prognostic factors and lymph node involvement, disease-free survival, and overall survival (OS) using a case-control group consisting of grade I-II endometrioid endometrial carcinoma (EEC) patients with/without lymph node involvement. The files of the patients were searched electronically for all hysterectomy specimens with a diagnosis of grade I-II EEC of the uterine body from January 1, 2008 to July 31, 2014...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319571/hpv-independent-differentiated-vulvar-intraepithelial-neoplasia-dvin-is-associated-with-an-aggressive-clinical-course
#11
Jessica N McAlpine, So Youn Kim, Ardalan Akbari, Sima Eshragh, Miriam Reuschenbach, Magnus von Knebel Doeberitz, Elena S Prigge, Suzanne Jordan, Naveena Singh, Dianne M Miller, C Blake Gilks
Differentiated vulvar intrapeithelial neoplasia (dVIN) is an human papillomavirus (HPV)-independent precursor of squamous cell carcinoma (SCC), and the aim of this study was to better characterize its natural history. Cases of dVIN were identified from the pathology archives. Outcomes of patients with dVIN only, without associated invasive SCC, were compared with a cohort of patients with high-grade squamous intraepithelial lesion [HSIL(VIN3)]. Eighteen patients diagnosed with dVIN with adjacent invasive SCC (SCC/dVIN) and 7 patients with dVIN only, without invasive carcinoma, were identified...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319570/microcystic-elongated-and-fragmented-pattern-invasion-in-ovarian-endometrioid-carcinoma-immunohistochemical-profile-and-prognostic-implications
#12
Allison Goldberg, Lauren Hand, Dan DeCotiis, Norman Rosenblum, Joanna Chan
Microcystic, elongated, and fragmented (MELF) pattern invasion is a poor prognostic indicator in uterine endometrioid carcinoma, but its existence, biology, and prognostic value have not been described in ovarian endometrioid carcinoma. We evaluated cases of ovarian endometrioid carcinoma without synchronous uterine endometrioid carcinoma for MELF and other histologic features. To evaluate tumor biology, we assessed an immunohistochemical profile, including MLH1, PMS2, MSH2, MSH6, β-catenin, e-cadherin, CK19, and cyclin D1...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28319528/postburn-microstomia-prevention-using-an-appliance-providing-simultaneous-horizontal-and-vertical-adjustable-forces
#13
Gregory S Antonarakis, Sandra Fastlicht, Taras Masnyi, Bryan Tompson
Microstomia, an abnormally small oral orifice, is a complication of perioral facial burns. In this case, contraction of the circumoral tissues and hypotonia of the musculature is responsible for this microstomia, which can produce aesthetic and functional impairment with eating, swallowing, communication (speech and facial expressions), compromised dental care and maintenance due to limited oral access, social interactions, and psychological well-being. Conservative management involves providing physical resistance to scar contracture, with opposing horizontal and vertical circumoral forces by means of appliances that aim to stretch the commissures and fibrotic muscles...
March 13, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28319463/solid-cancer-incidence-among-the-life-span-study-of-atomic-bomb-survivors-1958-2009
#14
Eric J Grant, Alina Brenner, Hiromi Sugiyama, Ritsu Sakata, Atsuko Sadakane, Mai Utada, Elizabeth K Cahoon, Caitlin M Milder, Midori Soda, Harry M Cullings, Dale L Preston, Kiyohiko Mabuchi, Kotaro Ozasa
This is the third analysis of solid cancer incidence among the Life Span Study (LSS) cohort of atomic bomb survivors in Hiroshima and Nagasaki, adding eleven years of follow-up data since the previously reported analysis. For this analysis, several changes and improvements were implemented, including updated dose estimates (DS02R1) and adjustment for smoking. Here, we focus on all solid cancers in aggregate. The eligible cohort included 105,444 subjects who were alive and had no known history of cancer at the start of follow-up...
March 20, 2017: Radiation Research
https://www.readbyqxmd.com/read/28319428/two-cases-of-first-onset-intrahepatic-cholestasis-of-pregnancy-associated-with-moderate-ovarian-hyperstimulation-syndrome-after-ivf-treatment-and-review-of-the-literature
#15
Mehmet Firat Mutlu, Koray Aslan, Ismail Guler, Ilknur Mutlu, Mehmet Erdem, Nuray Bozkurt, Ahmet Erdem
Intrahepatic cholestasis of pregnancy (ICP) is an uncommon disorder, which generally occurs in the second and third trimester of pregnancy with symptoms of pruritus. The cause of ICP is unknown but genetic, hormonal and environmental factors contribute to its pathogenesis. The aetiology of ICP is unclear but elevation in oestrogen levels thought to cause ICP is typically seen in the third trimester of pregnancy, and for this reason it is not usually considered in the differential diagnosis of pruritus and liver function disorders in the first trimester of the pregnancy...
March 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28319238/behavioral-and-neural-constraints-on-hierarchical-representations
#16
Odelia Schwartz, Luis Gonzalo Sanchez Giraldo
Central to behavior and cognition is the way that sensory stimuli are represented in neural systems. The distributions over such stimuli enjoy rich structure; however, how the brain captures and exploits these regularities is unclear. Here, we consider different sources of perhaps the most prevalent form of structure, namely hierarchies, in one of its most prevalent cases, namely the representation of images. We review experimental approaches across a range of subfields, spanning inference, memory recall, and visual adaptation, to investigate how these constrain hierarchical representations...
March 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28319153/a-general-model-for-metabolic-scaling-in-self-similar-asymmetric-networks
#17
Alexander Byers Brummer, Van M Savage, Brian J Enquist
How a particular attribute of an organism changes or scales with its body size is known as an allometry. Biological allometries, such as metabolic scaling, have been hypothesized to result from selection to maximize how vascular networks fill space yet minimize internal transport distances and resistances. The West, Brown, Enquist (WBE) model argues that these two principles (space-filling and energy minimization) are (i) general principles underlying the evolution of the diversity of biological networks across plants and animals and (ii) can be used to predict how the resulting geometry of biological networks then governs their allometric scaling...
March 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28318935/vector-model-supported-optimization-in-volumetric-modulated-arc-stereotactic-radiotherapy-planning-for-brain-metastasis
#18
Eva Sau Fan Liu, Vincent Wing Cheung Wu, Benjamin Harris, Matthew Foote, Margot Lehman, Lawrence Wing Chi Chan
Long planning time in volumetric-modulated arc stereotactic radiotherapy (VMA-SRT) cases can limit its clinical efficiency and use. A vector model could retrieve previously successful radiotherapy cases that share various common anatomic features with the current case. The prsent study aimed to develop a vector model that could reduce planning time by applying the optimization parameters from those retrieved reference cases. Thirty-six VMA-SRT cases of brain metastasis (gender, male [n = 23], female [n = 13]; age range, 32 to 81 years old) were collected and used as a reference database...
March 17, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28318833/bibliometric-analysis-of-the-scientific-production-as-regards-statin-use-for-ophthalmological-symptoms-of-myasthenia-gravis
#19
S M Salado-Font, F López-Muñoz, F J Povedano-Montero, F Labella Quesada
INTRODUCTION: The first symptoms of myasthenia gravis (MG) usually involve weakness of the ocular muscles, making it relevant that ophthalmologists have updated information on studies as regards its relationship with the consumption of drugs, such as statins. MATERIALS AND METHODS: A bibliometric analysis was performed using the Scopus database and by a search strategy in the selection of documents containing descriptors related to statins in the «Title» («TI») field and the descriptors «ophthalm *', «myast *', «visual *' in other fields of the document (period 1986-2015)...
March 16, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28318820/sarcoidosis-associated-small-fiber-neuropathy-in-a-large-cohort-clinical-aspects-and-response-to-ivig-and-anti-tnf-alpha-treatment
#20
Jinny O Tavee, Karen Karwa, Zubair Ahmed, Nicolas Thompson, Joseph Parambil, Daniel A Culver
OBJECTIVE: Small fiber neuropathy commonly affects patients with sarcoidosis and is often refractory to standard immunosuppressive therapies used for systemic disease. The clinical features of sarcoidosis-associated small fiber neuropathy (SSFN) and its response to medical therapy have not been described in a large population. METHODS: We performed a retrospective review of patients with SSFN seen at the Cleveland Clinic over a 4-year period. RESULTS: SSFN was identified in 143 individuals although other causes of neuropathy were found in 28 cases...
March 9, 2017: Respiratory Medicine
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