Filip Bouckaert, Louise Emsell, Kristof Vansteelandt, François-Laurent De Winter, Jan Van den Stock, Jasmien Obbels, Annemieke Dols, Max Stek, Katarzyna Adamczuk, Stefan Sunaert, Koen Van Laere, Pascal Sienaert, Mathieu Vandenbulcke
BACKGROUND: Gray matter volume decrease, white matter vascular pathology and amyloid accumulation are age-related brain changes that have been related to the pathogenesis of late life depression (LLD). Furthermore, lower hippocampal volume and more white matter hyperintensities (WMH) may contribute to poor response to electroconvulsive therapy (ECT) in severely depressed older adults. We hypothesized that the accumulation of age-related brain changes negatively affects outcome following ECT in LLD...
May 15, 2019: Journal of Affective Disorders