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refractary hypotension

Andreea Privistirescu, Alexandra Sima, Oana M Duicu, Romulus Timar, Mariana G Roșca, Adrian Sturza, Danina M Muntean
Endothelial dysfunction and the related increase in reactive oxygen species (ROS) production are important events in the pathophysiology of diabetes mellitus (DM). Methylene blue (MB) has been systematically investigated for its protective effects against refractary hypotension and mitochondrial dysfunction. We have previously demonstrated that MB improved mitochondrial respiration and partially decreased oxidative stress in diabetic rat hearts. The present study was aimed to investigate whether MB modulates vascular function and ROS production in thoracic aortic rings isolated from rats with streptozotocin-induced DM (after 4 weeks of hyperglicemia)...
June 12, 2018: Canadian Journal of Physiology and Pharmacology
M A Alama Zaragoza, A Robles Iniesta, I Roca Adelantado, M A Sales Maicas, M C Navarro de León, P Román Sánchez
A case of primary adrenal bilateral non-Hodgking lymphoma, with depressed adrenal reserve is presented. This rare neoplasm causes rapid evolution and fatal outcome in most cases. In our patient, lethal outcome was associated with severe hypercalcemia and refractary hypotension. Many other complications are due to tumoral lysis syndrome associated with high steroid doses in adrenal insufficiency. This rare entity must be included in the differencial diagnosis of adrenal masses, uni or bilateral, because early diagnostic is important for preventing complications, potentially lethals and for improving survival...
October 2002: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
A Valdivielso, J Casado Flores, A Ruiz Beltrán, J García Pérez, M García-Onieva, I Hidalgo
Naloxone clorhidrate was administered intravenously to 15 patients with endotoxic shock and refractary hypotension, following meningococcal sepsis. Doses used were between 0.01-0.2 mg/kg. Three patients (two of them with moderate shock) showed an increase in sistolic arterial pressure, which was maintained and above 20 mm/Hg. Among the rest of them (except one with severe shock) naloxone action was non-existent in nine cases, or with short action and without answer to next doses in other three. Eleven patients died...
February 15, 1984: Anales Españoles de Pediatría
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