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https://www.readbyqxmd.com/read/28228731/increased-hemodynamic-load-in-early-embryonic-stages-alters-endocardial-to-mesenchymal-transition
#1
Madeline Midgett, Claudia S López, Larry David, Alina Maloyan, Sandra Rugonyi
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow to cardiac defects remain unclear. Endothelial-mesenchymal cell transition is one of the many complex developmental events involved in transforming the early embryonic outflow tract into the aorta, pulmonary trunk, interventricular septum, and semilunar valves...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28227775/3d-anatomical-reconstruction-of-human-cardiac-conduction-system-and-simulation-of-bundle-branch-block-after-tavi-procedure
#2
Andrew J Atkinson, Sanjay R Kharche, Michael G Bateman, Paul A Iaizzo, Halina Dobrzynski, Andrew J Atkinson, Sanjay R Kharche, Michael G Bateman, Paul A Iaizzo, Halina Dobrzynski, Andrew J Atkinson, Paul A Iaizzo, Halina Dobrzynski, Sanjay R Kharche, Michael G Bateman
The cardiac conduction system (CCS) is responsible for the initiation and propagation of action potentials through the heart ensuring efficient pumping of blood. Understanding the anatomy of the CCS and its relationship with other major cardiac components is important to help understand arrhythmias and how certain procedures may increase the incidence of arrhythmias developing. We sectioned a whole human heart and performed Masson's trichrome histology in order to identify the components of the CCS. The histology images were used to construct a 3D anatomical model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227773/whole-heart-modeling-spatiotemporal-dynamics-of-electrical-wave-conduction-and-propagation
#3
Hui Yang, Yun Chen, Fabio M Leonelli, Hui Yang, Yun Chen, Fabio M Leonelli, Hui Yang, Fabio M Leonelli, Yun Chen
Cardiac electrical activities are varying in both space and time. Human heart consists of a fractal network of muscle cells, Purkinje fibers, arteries and veins. Whole-heart modeling of electrical wave conduction and propagation involves a greater level of complexity. Our previous work developed a computer model of the anatomically realistic heart and simulated the electrical conduction with the use of cellular automata. However, simplistic assumptions and rules limit its ability to provide an accurate approximation of real-world dynamics on the complex heart surface, due to sensitive dependence of nonlinear dynamical systems on initial conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227427/inexact-coronary-tree-matching-algorithm-with-artificial-nodes
#4
Helene Feuillatre, Jean-Claude Nunes, Christine Toumoulin, Helene Feuillatre, Jean-Claude Nunes, Christine Toumoulin, Jean-Claude Nunes, Helene Feuillatre, Christine Toumoulin
Coronary tree matching is applied to plan percutaneous vascular procedures. This work, which allows following each segment of non-isomorphic coronary trees over time, precedes the determination of the best 2D angiography view from C-arm acquisition system for angioplasty procedure. To match two 3D coronary trees which represent two successive cardiac phases, we adapted a reference inexact tree matching algorithm based on association graph and maximum clique. To improve the pair-wise matching performance of our approach, artificial nodes are introduced to take into account the topology variation between 3D vascular trees...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227423/dynamic-mapping-of-ventricular-function-from-cardiovascular-magnetic-resonance-imaging
#5
Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Alexander Brost, Tom Jackson, Maria Panayiotou, Christopher A Rinaldi, Jonathan M Behar, R James Housden, Kawal S Rhode, Daniel Toth, Peter Mountney
Heart failure is associated with substantial mortality and morbidity and remains the most common diagnosis in older patients. Based on experimental electrophysiologic studies, cardiac resynchronization therapy (CRT) for heart failure results in a maximum resynchronization effect when applied to the most delayed left ventricular (LV) site. Current clinical practice is to identify the optimal site using separate visualisation of scar and activation information. These must be mentally mapped into 3D, which is challenging and time-consuming for the electrophysiologist...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227221/fundamentals-of-left-ventricular-volume-representation
#6
Peter L Kerkhof, Peter L Kerkhof, Peter L Kerkhof
The volume regulation graph is meant to relate the fundamental determinants of left ventricular (LV) function, namely end-systolic volume (ESV) and end-diastolic volume (EDV). This representation permits evaluation of the LV remodeling process, convenient stratification for clinically relevant covariates, as well as inscription of iso-stroke volume (SV) and iso-ejection fraction (EF) trajectories, the latter two as linear relationships. This retrospective study discusses LV volumetric parameters obtained from 155 patients (65 females) covering a wide spectrum of heart diseases...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227204/ultrasound-plane-wave-imaging-with-delay-multiply-and-sum-beamforming-and-coherent-compounding
#7
Giulia Matrone, Alessandro S Savoia, Giosue Caliano, Giovanni Magenes, Giulia Matrone, Alessandro S Savoia, Giosue Caliano, Giovanni Magenes, Giulia Matrone, Giovanni Magenes, Alessandro S Savoia, Giosue Caliano
Improving the frame rate is an important aspect in medical ultrasound imaging, particularly in 3D/4D cardiac applications. However, an accurate trade-off between the higher frame rate and image contrast and resolution should be performed. Plane-Wave Imaging (PWI) can potentially achieve frame rates in the order of 10 kHz, as it uses a single unfocused plane wave (and thus a single transmit event) to acquire the image of the entire region of interest. The lack of transmit focusing however causes a significant drop of image quality, which can be restored by coherently compounding several tilted plane-wave frames, at the expense of the frame rate...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227086/catheter-simulator-software-tool-to-generate-electrograms-of-any-multi-polar-diagnostic-catheter-from-3d-atrial-tissue
#8
Kristina E Shillieto, Prasanth Ganesan, Anthony J Salmin, Elizabeth M Cherry, Arkady M Pertsov, Behnaz Ghoraani, Kristina E Shillieto, Prasanth Ganesan, Anthony J Salmin, Elizabeth M Cherry, Arkady M Pertsov, Behnaz Ghoraani, Arkady M Pertsov, Behnaz Ghoraani, Anthony J Salmin, Kristina E Shillieto, Elizabeth M Cherry, Prasanth Ganesan
Simulations are excellent tools for assessing new therapeutic strategies and are often conducted before implementing new therapy options in a clinical practice. For patients suffering from a heart arrhythmia, the main source of information comes from an intracardiac catheter. One of the common catheters is a Lasso multi-pole diagnostic catheter, which is a catheter that has 20 electrodes in a circular pattern. In this paper, we developed algorithm and simulation software that allows the users to place a multi-pole catheter on the atrial endocardial surface and record electrograms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227084/development-of-data-acquisition-components-for-simultaneous-recording-of-3d-epicardial-and-surface-ecg-signals-in-the-langendorff-perfusion-apparatus
#9
Ryan Wade Selby, Anup Jonchhe, Chen Kaplan, Coeli M Lopes, Behnaz Ghoraani, Ryan Wade Selby, Anup Jonchhe, Chen Kaplan, Coeli M Lopes, Behnaz Ghoraani, Chen Kaplan, Behnaz Ghoraani, Anup Jonchhe, Coeli M Lopes, Ryan Wade Selby
Sudden Cardiac Death (SCD) claims 7 million lives per year. The importance of myocardial electrogram (EGM) repolarization alternans and surface electrocardiogram (ECG) T-wave alternans is gaining traction for understanding the underlying SCD mechanisms. However, the relationship between the 3D spatial distribution of myocardial EGMs and surface ECG with respect to SCD has yet to be investigated. To make this happen, a modified data acquisition system has been developed and fabricated in conjunction with the Langendorff perfusion system to enable simultaneous recording and analysis of the 3D spatial distribution of myocardial EGMs and the surface ECG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226689/patient-movement-compensation-for-3d-echocardiography-fusion
#10
Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Allen He, Pierre Boulanger, Harald Becher, Michelle Noga, Kumaradevan Punithakumar, Michelle Hanbidge, Abhilash R Hareendranathan
Limited field of view (FOV) is a major problem for 3D real-time echocardiography (3DRTE), which results in an incomplete representation of cardiac anatomy. Various image registration techniques have been proposed to improve the field of view in 3DRTE by fusing multiple image volumes. However, these techniques require significant overlap between the individual volumes and rely on high image resolution and high signal-to-noise ratio. Changes in the heart position due to patient movement during image acquisition can also reduce the quality of image fusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226688/mitral-valve-annulus-localization-in-3d-echocardiography
#11
Abhishek Tiwari, Kedar A Patwardhan, Abhishek Tiwari, Kedar A Patwardhan, Kedar A Patwardhan, Abhishek Tiwari
The Mitral Valve is a structure on the left side of the human heart that regulates the flow of oxygenated blood into the Left Ventricle and also helps maintain the pressure within the Left Ventricle when the blood gets pumped to the rest of the body from the Left Ventricle. Pathology of the Mitral Valve often manifests through structural changes in the anatomy. Assessment of Mitral Valve pathology as well as determination of specific interventions require quantification of various structures of the Mitral Valve and one of these structures of interest is the Mitral Valve annulus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226544/kurtosis-as-a-statistical-approach-to-identify-the-pivot-point-of-the-rotor
#12
Shivaram P Arunachalam, Elizabeth M Annoni, Siva K Mulpuru, Paul A Friedman, Elena G Tolkacheva, Shivaram P Arunachalam, Elizabeth M Annoni, Siva K Mulpuru, Paul A Friedman, Elena G Tolkacheva, Elena G Tolkacheva, Paul A Friedman, Elizabeth M Annoni, Siva K Mulpuru, Shivaram P Arunachalam
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia that causes stroke affecting more than 2.3 million people in the US. Catheter ablation to terminate AF is successful for paroxysmal AF but suffers limitations with persistent AF patients as current mapping methods cannot identify AF active substrates outside of pulmonary vein region. In this work, we developed a novel Kurtosis based mapping technique that can accurately identify pivot points of the rotors that were induced in ex-vivo isolated rabbit heart...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220995/development-of-hydrogels-for-regenerative-engineering
#13
REVIEW
Xiaofei Guan, Meltem Avci-Adali, Emine Alarçin, Hao Cheng, Sara Saheb Kashaf, Yuxiao Li, Aditya Chawla, Hae Lin Jang, Ali Khademhosseini
The aim of regenerative engineering is to restore complex tissues and biological systems through convergence in the fields of advanced biomaterials, stem cell science, and developmental biology. Hydrogels are one of the most attractive biomaterials for regenerative engineering, since they can be engineered into tissue mimetic 3D scaffolds to support cell growth due to their similarity to native extracellular matrix. Advanced nano- and micro-technologies have dramatically increased the ability to control properties and functionalities of hydrogel materials by facilitating biomimetic fabrication of more sophisticated compositions and architectures, thus extending our understanding of cell-matrix interactions at the nanoscale...
February 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28214968/piloting-the-use-of-patient-specific-cardiac-models-as-a-novel-tool-to-facilitate-communication-during-cinical-consultations
#14
Giovanni Biglino, Despina Koniordou, Marisa Gasparini, Claudio Capelli, Lindsay-Kay Leaver, Sachin Khambadkone, Silvia Schievano, Andrew M Taylor, Jo Wray
This pilot study aimed to assess the impact of using patient-specific three-dimensional (3D) models of congenital heart disease (CHD) during consultations with adolescent patients. Adolescent CHD patients (n = 20, age 15-18 years, 15 male) were asked to complete two questionnaires during a cardiology transition clinic at a specialist centre. The first questionnaire was completed just before routine consultation with the cardiologist, the second just after the consultation. During the consultation, each patient was presented with a 3D full heart model realised from their medical imaging data...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28213948/hourglass-shaped-right-ventricle-and-localized-constrictive-pericarditis
#15
Alper Karakus, Hasan Ari, Sencer Camci, Selma Ari, Ahmet Tutuncu, Mehmet Melek
Constrictive pericarditis is characterized by thick pericardial fibrosis and frequent calcification that progressively impairs diastolic filling of the heart. The diagnosis of constrictive pericarditis has been challenging even though multiple diagnostic modalities have been developed. The diagnosis of constructive pericarditis is especially difficult in localized constrictive pericarditis which is extremely rare. We report a case of localized constrictive pericarditis with a 3D multislice cardiac computed tomography (CT) finding of the constrictive band causing strangulation and hourglass shaping of the right ventricle...
February 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28208231/fast-left-ventricle-tracking-using-localized-anatomical-affine-optical-flow
#16
Sandro Queirós, João L Vilaça, Pedro Morais, Jaime C Fonseca, Jan D'hooge, Daniel Barbosa
In daily clinical cardiology practice, left ventricle (LV) global and regional function assessment is crucial for disease diagnosis, therapy selection and patient follow-up. Currently, this is still a time-consuming task, spending valuable human resources. In this work, a novel fast methodology for automatic LV tracking is proposed based on localized anatomically constrained affine optical flow. This novel method can be combined to previously proposed segmentation frameworks or manually delineated surfaces at an initial frame to obtain fully delineated datasets and, thus, assess both global and regional myocardial function...
February 16, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28205119/use-of-three-dimensional-computed-tomography-overlay-for-real-time-cryoballoon-ablation-in-atrial-fibrillation-reduces-radiation-dose-and-contrast-dye
#17
B Oude Velthuis, M Molenaar, H G Reinhart Dorman, J Y Stevenhagen, M F Scholten, J van der Palen, J M van Opstal
AIMS: Cryoballoon pulmonary vein (PV) isolation in patients with atrial fibrillation has proven to be effective in short-term and long-term follow-up. To visualise the PV anatomy, pre-ablation contrast pulmonary venography is commonly performed. Three-dimensional (3D) computed tomography (CT) overlay is a new technique creating a live 3D image of the left atrium by integrating a previously obtained CT scan during fluoroscopy. To evaluate the benefits of 3D CT overlay during cryoballoon ablation, we studied the use of 3D CT overlay versus contrast pulmonary venography in a randomised fashion in patients with paroxysmal atrial fibrillation undergoing cryoballoon PV isolation...
February 15, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28202854/three-dimensional-cardiac-mr-imaging-related-techniques-and-clinical-applications
#18
Yasuo Amano, Fumi Yanagisawa, Masaki Tachi, Kuniya Asai, Yasuyuki Suzuki, Hidenobu Hashimoto, Kiyohisa Ishihara, Shinichiro Kumita
Three-dimensional (3D) cardiac magnetic resonance (MR) imaging has several advantages, including the easy coverage of the entire heart without misregistration, reduction of breath-holding times, and availability for postprocessing reconstruction. These advantages are associated with some techniques such as breath-hold or navigator gating and parallel imaging. However, the image quality of 3D cardiac MR images is compromised by the use of a shorter repetition time and parallel imaging. Thus, a steady-state free precession sequence, contrast agent administration, and presaturation pulses are used to maintain the image quality...
February 16, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28198938/left-atrial-deformation-analysis-in-patients-with-corrected-tetralogy-of-fallot-by-3d-speckle-tracking-echocardiography-from-the-magyar-path-study
#19
Kálmán Havasi, Péter Domsik, Anita Kalapos, Jackie S McGhie, Jolien W Roos-Hesselink, Tamás Forster, Attila Nemes
Background: Three-dimensional (3D) echocardiography coupled with speckle-tracking echocardiographic (STE) capability is a novel methodology which has been demontrated to be useful for the assessment of left atrial (LA) volumes and functional properties. There is increased scientific interest on myocardial deformation analysis in adult patients with corrected tetralogy of Fallot (cTOF). Objectives: To compare LA volumes, volume-based functional properties and strain parameters between cTOF patients and age- and gender-matched healthy controls...
February 13, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28195834/surface-acoustic-waves-induced-micropatterning-of-cells-in-gelatin-methacryloyl-gelma-hydrogels
#20
Shahid M Naseer, Amir Manbachi, Mohamadmahdi Samandari, Philipp Walch, Yuan Gao, Yu Shrike Zhang, Farideh Davoudi, Wesley Wang, Karen Abrinia, Jonathan M Cooper, Ali Khademhosseini, Su Ryon Shin
Acoustic force patterning is an emerging technology that provides a platform to control the spatial location of cells in a rapid, accurate, yet contactless manner. However, very few studies have been reported on the usage of acoustic force patterning for the rapid arrangement of biological objects, such as cells, in a three-dimensional (3D) environment. In this study, we report on a bio-acoustic force patterning technique, which uses surface acoustic waves (SAWs) for the rapid arrangement of cells within an extracellular matrix-based hydrogel such as gelatin methacryloyl (GelMA)...
February 14, 2017: Biofabrication
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