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https://www.readbyqxmd.com/read/29058110/computational-prediction-of-the-effects-of-the-intra-aortic-balloon-pump-on-heart-failure-with-valvular-regurgitation-using-a-3d-cardiac-electromechanical-model
#1
Chang-Hyun Kim, Kwang-Soup Song, Natalia A Trayanova, Ki Moo Lim
Intra-aortic balloon pump (IABP) is normally contraindicated in significant aortic regurgitation (AR). It causes and aggravates pre-existing AR while performing well in the event of mitral regurgitation (MR). Indirect parameters, such as the mean systolic pressure, product of heart rate and peak systolic pressure, and pressure-volume are used to quantify the effect of IABP on ventricular workload. However, to date, no studies have directly quantified the reduction in workload with IABP. The goal of this study is to examine the effect of IABP therapy on ventricular mechanics under valvular insufficiency by using a computational model of the heart...
October 23, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29058109/a-3d-hermite-based-multiscale-local-active-contour-method-with-elliptical-shape-constraints-for-segmentation-of-cardiac-mr-and-ct-volumes
#2
Leiner Barba-J, Boris Escalante-Ramírez, Enrique Vallejo Venegas, Fernando Arámbula Cosío
Analysis of cardiac images is a fundamental task to diagnose heart problems. Left ventricle (LV) is one of the most important heart structures used for cardiac evaluation. In this work, we propose a novel 3D hierarchical multiscale segmentation method based on a local active contour (AC) model and the Hermite transform (HT) for LV analysis in cardiac magnetic resonance (MR) and computed tomography (CT) volumes in short axis view. Features such as directional edges, texture, and intensities are analyzed using the multiscale HT space...
October 23, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29057926/engraftment-and-morphological-development-of-vascularized-human-ips-cell-derived-3d-cardiomyocyte-tissue-after-xenotransplantation
#3
Hirokazu Narita, Fumiaki Shima, Junya Yokoyama, Shigeru Miyagawa, Yoshinari Tsukamoto, Yasushi Takamura, Ayami Hiura, Ken Fukumoto, Tomohiro Chiba, Seiji Watanabe, Yoshiki Sawa, Mitsuru Akashi, Hiroshi Shimoda
One of the major challenges in cell-based cardiac regenerative medicine is the in vitro construction of three-dimensional (3D) tissues consisting of induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) and a blood vascular network supplying nutrients and oxygen throughout the tissue after implantation. We have successfully built a vascularized iPSC-CM 3D-tissue using our validated cell manipulation technique. In order to evaluate an availability of the 3D-tissue as a biomaterial, functional morphology of the tissues was examined by light and transmission electron microscopy through their implantation into the rat infarcted heart...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057872/modelling-torsade-de-pointes-arrhythmias-in-vitro-in-3d-human-ips-cell-engineered-heart-tissue
#4
Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K Yamashita
Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug sensitivity of human cardiac tissue. Here, we present an in vitro TdP model using 3D cardiac tissue sheets (CTSs) that contain a mixture of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and non-myocytes. We simultaneously monitor the extracellular field potential (EFP) and the contractile movement of the CTSs. Upon treatment with IKr channel blockers, CTSs exhibit tachyarrhythmias with characteristics of TdP, including both a typical polymorphic EFP and meandering spiral wave re-entry...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29057000/fusion-of-real-time-3d-transesophageal-echocardiography-and-cardiac-fluoroscopy-imaging-in-transapical-catheter-based-mitral-paravalvular-leak-closure
#5
Aleksejus Zorinas, Vilius Janusauskas, Giedrius Davidavicius, Lina Puodziukaite, Diana Zakarkaite, Rita Kramena, Rasa Čypienė, Valdas Bilkis, Kestutis Rucinskas, Audrius Aidietis, Eustaquio M Onorato
No abstract text is available yet for this article.
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29053691/quantitative-whole-mount-immunofluorescence-analysis-of-cardiac-progenitor-populations-in-mouse-embryos
#6
Evan Bardot, Nikos Tzavaras, Deanna L Benson, Nicole C Dubois
The use of ever-advancing imaging techniques has contributed broadly to our increased understanding of embryonic development. Pre-implantation development and organogenesis are two areas of research that have benefitted greatly from these advances, due to the high quality of data that can be obtained directly from imaging pre-implantation embryos or ex vivo organs. While pre-implantation embryos have yielded data with especially high spatial resolution, later stages have been less amenable to three-dimensional reconstruction...
October 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29050957/heart-dosimetric-analysis-of-three-types-of-cardiac-toxicity-in-patients-treated-on-dose-escalation-trials-for-stage-iii-non-small-cell-lung-cancer
#7
Kyle Wang, Kevin A Pearlstein, Nicholas D Patchett, Allison M Deal, Panayiotis Mavroidis, Brian C Jensen, Matthew B Lipner, Timothy M Zagar, Yue Wang, Carrie B Lee, Michael J Eblan, Julian G Rosenman, Mark A Socinski, Thomas E Stinchcombe, Lawrence B Marks
BACKGROUND AND PURPOSE: To assess associations between radiation dose/volume parameters for cardiac subvolumes and different types of cardiac events in patients treated on radiation dose-escalation trials. MATERIAL AND METHODS: Patients with Stage III non-small-cell lung cancer received dose-escalated radiation (median 74 Gy) using 3D-conformal radiotherapy on six prospective trials from 1996 to 2009. Volumes analyzed included whole heart, left ventricle (LV), right atrium (RA), and left atrium (LA)...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29050528/uv-assisted-3d-bioprinting-of-nano-reinforced-hybrid-cardiac-patch-for-myocardial-tissue-engineering
#8
Mohammad Izadifar, Dean Chapman, Paul Babyn, Xiongbiao Chen, Michael E Kelly
Biofabrication of cell supportive cardiac patches that can be directly implanted on myocardial infarct is a potential solution for myocardial infarction repair. Ideally, cardiac patches should be able to mimic myocardium extracellular matrix for rapid integration with the host tissue, raising the need to develop cardiac constructs with complex features. In particular, cardiac patches should be electrically conductive, mechanically robust and elastic, biologically active and pre-vascularized.. In this study, we aim to biofabricate a nano-reinforced hybrid cardiac patch laden with human coronary artery endothelial cells (HCAECs) with improved electrical, mechanical and biological behavior...
October 19, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29048460/cardiovascular-magnetic-resonance-imaging-in-patients-with-cardiac-implantable-electronic-devices-a-device-dependent-imaging-strategy-for-improved-image-quality
#9
Sebastian Hilbert, Cosima Jahnke, Susanne Loebe, Sabrina Oebel, Alexander Weber, Ricardo Spampinato, Sergio Richter, Michael Doering, Andreas Bollmann, Philipp Sommer, Gerhard Hindricks, Ingo Paetsch
Aims: To prospectively determine evaluability of routine cardiovascular magnetic resonance (CMR) diagnostic modules in a referral population of implanted rhythm device all-comers, and to establish a device-dependent CMR imaging strategy to achieve optimal image quality. Methods and results: One hundred and twenty-eight patients with cardiac implantable electronic devices [insertable cardiac monitoring system, n = 14; implantable loop-recorder, n = 21; pacemaker, n = 31; implantable cardioverter-defibrillator (ICD), n = 50; and cardiac resynchronization therapy defibrillator (CRT-D), n = 12] underwent clinically indicated CMR at 1...
October 18, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29046645/computational-cardiac-modeling-reveals-mechanisms-of-ventricular-arrhythmogenesis-in-long-qt-syndrome-type-8-cacna1c-r858h-mutation-linked-to-ventricular-fibrillation
#10
Jieyun Bai, Kuanquan Wang, Yashu Liu, Yacong Li, Cuiping Liang, Gongning Luo, Suyu Dong, Yongfeng Yuan, Henggui Zhang
Functional analysis of the L-type calcium channel has shown that the CACNA1C R858H mutation associated with severe QT interval prolongation may lead to ventricular fibrillation (VF). This study investigated multiple potential mechanisms by which the CACNA1C R858H mutation facilitates and perpetuates VF. The Ten Tusscher-Panfilov (TP06) human ventricular cell models incorporating the experimental data on the kinetic properties of L-type calcium channels were integrated into one-dimensional (1D) fiber, 2D sheet, and 3D ventricular models to investigate the pro-arrhythmic effects of CACNA1C mutations by quantifying changes in intracellular calcium handling, action potential profiles, action potential duration restitution (APDR) curves, dispersion of repolarization (DOR), QT interval and spiral wave dynamics...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29046643/trigger-vs-substrate-multi-dimensional-modulation-of-qt-prolongation-associated-arrhythmic-dynamics-by-a-herg-channel-activator
#11
Michael A Colman, Erick A Perez Alday, Arun V Holden, Alan P Benson
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia. Pharmacological management of arrhythmia associated with QT prolongation is typically achieved through attempting to restore APD to control ranges, reversing the enhanced vulnerability to Ca(2+)-dependent afterdepolarisations (arrhythmia triggers) and increased transmural dispersion of repolarisation (arrhythmia substrate) associated with APD prolongation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29045589/standardization-of-adult-transthoracic-echocardiography-reporting-in-agreement-with-recent-chamber-quantification-diastolic-function-and-heart-valve-disease-recommendations-an-expert-consensus-document-of-the-european-association-of-cardiovascular-imaging
#12
Maurizio Galderisi, Bernard Cosyns, Thor Edvardsen, Nuno Cardim, Victoria Delgado, Giovanni Di Salvo, Erwan Donal, Leyla Elif Sade, Laura Ernande, Madalina Garbi, Julia Grapsa, Andreas Hagendorff, Otto Kamp, Julien Magne, Ciro Santoro, Alexandros Stefanidis, Patrizio Lancellotti, Bogdan Popescu, Gilbert Habib
Aims: This European Association Cardiovascular Imaging (EACVI) Expert Consensus document aims at defining the main quantitative information on cardiac structure and function that needs to be included in standard echocardiographic report following recent ASE/EACVI chamber quantification, diastolic function, and heart valve disease recommendations. The document focuses on general reporting and specific pathological conditions such as heart failure, coronary artery and valvular heart disease, cardiomyopathies, and systemic diseases...
October 17, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29040438/geometric-predictors-of-left-ventricular-outflow-tract-obstruction-in-patients-with-hypertrophic-cardiomyopathy-a-3d-computed-tomography-analysis
#13
Yunsun Song, Dong Hyun Yang, Bríain Ó Hartaigh, Se Jin Cho, Joon-Won Kang, Young-Hak Kim, Joon Bum Kim, Dae-Hee Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Kwan Song, Tae-Hwan Lim
Aims: To establish geometric predictors of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) patients by use of cardiac computed tomography (CT). Methods and results: A total of 141 consecutive patients with HCM who underwent cardiac CT comprised the analytic sample. The degree, pattern, and extent of left ventricular (LV) hypertrophy were evaluated using 3D CT. Abnormality of papillary muscle (PM), mitral valve, and aorto-mitral angle were evaluated quantitatively...
October 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29031479/the-optimum-chest-compression-site-with-regard-to-heart-failure-demonstrated-by-computed-tomography
#14
Keunha Hwang, Sung-Bin Chon, Jung Gi Im
BACKGROUND: To determine the optimum chest compression site during cardiopulmonary resuscitation (CPR) with regard to heart failure (HF) by applying three-dimensional (3D) coordinates on computed tomography (CT). METHODS: This retrospective, cross-sectional study involved adults who underwent echocardiography and CT on the same day from 2007 to 2017. Incomplete CT images or information on HF, cardiac medication between echocardiography and CT, or thoracic abnormalities were excluded...
July 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29029074/multimodality-imaging-evaluation-of-chagas-disease-an-expert-consensus-of-brazilian-cardiovascular-imaging-department-dic-and-the-european-association-of-cardiovascular-imaging-eacvi
#15
Maria Carmo P Nunes, Luigi Paolo Badano, J Antonio Marin-Neto, Thor Edvardsen, Covadonga Fernández-Golfín, Chiara Bucciarelli-Ducci, Bogdan A Popescu, Richard Underwood, Gilbert Habib, Jose Luis Zamorano, Roberto Magalhães Saraiva, Ester Cerdeira Sabino, Fernando A Botoni, Márcia Melo Barbosa, Marcio Vinicius L Barros, Eduardo Falqueto, Marcus Vinicius Simões, André Schmidt, Carlos Eduardo Rochitte, Manoel Otávio Costa Rocha, Antonio Luiz Pinho Ribeiro, Patrizio Lancellotti
Aims: To develop a document by Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI) to review and summarize the most recent evidences about the non-invasive assessment of patients with Chagas disease, with the intent to set up a framework for standardized cardiovascular imaging to assess cardiovascular morphologic and functional disturbances, as well as to guide the subsequent process of clinical decision-making. Methods and results: Chagas disease remains one of the most prevalent infectious diseases in Latin America, and has become a health problem in non-endemic countries...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028783/three-dimensional-transesophageal-echocardiography-in-the-guide-of-cardiac-mass-biopsy-future-prospectives
#16
Daniela Di Lisi, Donatella Raspante, Vincenzo Lavanco, Mirko Curzi, Francesca Macaione, Massimo Cavallaro, Riccardo Tona, Giuseppina Novo, Salvatore Novo, Renato M Bragato
: Cardiac tumors are rare. Cardiovascular imaging is more important in the differential diagnosis of cardiac masses but no current noninvasive diagnostic tool has the ability to absolutely diagnose cardiac tumors. In effect cardiac biopsy remains the gold standard in the differential diagnosis. In our case we show the advantages of three-dimensional (3D) transesophageal echocardiography as a guide for cardiac biopsy. We believe that 3D TEE is ready to be used in the guide of cardiac mass biopsy. Once interventionalists become confident with 3D imaging, this technique should be used routinely during these procedures...
October 11, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29027633/multi-modality-imaging-in-the-evaluation-and-treatment-of-mitral-regurgitation
#17
REVIEW
Marc-André Bouchard, Claudia Côté-Laroche, Jonathan Beaudoin
Mitral regurgitation (MR) is frequent and associated with increased mortality and morbidity when severe. It may be caused by intrinsic valvular disease (primary MR) or ventricular deformation (secondary MR). Imaging has a critical role to document the severity, mechanism, and impact of MR on heart function as selected patients with MR may benefit from surgery whereas other will not. In patients planned for a surgical intervention, imaging is also important to select candidates for mitral valve (MV) repair over replacement and to predict surgical success...
October 13, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29025406/impact-of-empagliflozin-on-subclinical-left-ventricular-dysfunctions-and-on-the-mechanisms-involved-in-myocardial-disease-progression-in-type-2-diabetes-rationale-and-design-of-the-empa-heart-trial
#18
Andrea Natali, Lorenzo Nesti, Iacopo Fabiani, Enrico Calogero, Vitantonio Di Bello
BACKGROUND: Asymptomatic left ventricular (LV) dysfunction is highly prevalent in type 2 diabetes patients. Unlike the other hypoglycemic drugs, SGLT2 inhibitors have shown potential benefits for reducing cardiovascular death and risk factors, aside from lowering plasma glucose levels. With this study we aim at determining whether the treatment with empagliflozin is associated with an improvement in LV functions in diabetic patients with asymptomatic LV dysfunction against Sitagliptin, which is presumably neutral on myocardial function...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29024200/novel-automated-point-collection-software-facilitates-rapid-high-density-electroanatomical-mapping-with-multiple-catheter-types
#19
Leon M Ptaszek, Boyce Moon, Guy Rozen, Srijoy Mahapatra, Moussa Mansour
INTRODUCTION: Manual, point-by-point electroanatomical mapping requires the operator to directly evaluate each point during map construction. Consequently, point collection can be a slow process. An automated 3D mapping system was developed with the goal of improving key mapping metrics, including map completion time and point density. METHODS: Automated 3D mapping software that includes morphology and cycle length discrimination functions for surface and intracardiac electrograms was developed...
October 12, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29019794/vessel-calibre-and-flow-splitting-relationships-at-the-internal-carotid-artery-terminal-bifurcation
#20
Christophe Chnafa, Pierre Bouillot, Olivier Brina, Benedicte M A Delattre, Maria I Vargas, Karl-Olaf Lovblad, Vitor M Pereira, David A Steinman
Vessel lumen calibres and flow rates are thought to be related by mathematical power laws, reflecting the optimization of cardiac vs. metabolic work. While these laws have been confirmed indirectly via measurement of branch calibres, there is little data confirming power law relationships of flow distribution to branch calibres at individual bifurcations. Approach: Flow rates and diameters of parent and daughter vessels of the internal carotid artery terminal bifurcation were determined, via robust and automated methods, from 4D phase-contrast magnetic resonance imaging and 3D rotational angiography of 31 patients...
October 11, 2017: Physiological Measurement
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