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https://www.readbyqxmd.com/read/29473982/longitudinal-changes-in-myocardial-t-1-and-t-2-relaxation-times-related-to-diffuse-myocardial-fibrosis-in-aortic-stenosis-before-and-after-aortic-valve-replacement
#1
Sofia Kvernby, Mattias Rönnerfalk, Marcel Warntjes, Carl-Johan Carlhäll, Eva Nylander, Jan Engvall, Éva Tamás, Tino Ebbers
BACKGROUND: Diffuse myocardial fibrosis is associated with adverse outcomes, although detection and quantification is challenging. Cardiac MR relaxation times mapping represents a promising imaging biomarker for diffuse myocardial fibrosis. PURPOSE: To investigate whether relaxation times can detect longitudinal changes in myocardial tissue composition associated with diffuse fibrosis in patients with severe aortic stenosis (AS) before and after aortic valve replacement (AVR)...
February 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29472302/quantification-of-intracranial-aneurysm-volume-pulsation-with-7t-mri
#2
R Kleinloog, J J M Zwanenburg, B Schermers, E Krikken, Y M Ruigrok, P R Luijten, F Visser, L Regli, G J E Rinkel, B H Verweij
BACKGROUND AND PURPOSE: Aneurysm volume pulsation is a potential predictor of intracranial aneurysm rupture. We evaluated whether 7T MR imaging can quantify aneurysm volume pulsation. MATERIALS AND METHODS: In Stage I of the study, 10 unruptured aneurysms in 9 patients were studied using a high-resolution (0.6-mm, isotropic) 3D gradient-echo sequence with cardiac gating. Semiautomatic segmentation was used to measure aneurysm volume (in cubic millimeters) per cardiac phase...
February 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29472089/investigation-of-the-xcat-phantom-as-a-validation-tool-in-cardiac-mri-tracking-algorithms
#3
Nicholas Lowther, Svenja Ipsen, Steven Marsh, Oliver Blanck, Paul Keall
PURPOSE: To describe our magnetic resonance imaging (MRI) simulated implementation of the 4D digital extended cardio torso (XCAT) phantom to validate our previously developed cardiac tracking techniques. Real-time tracking will play an important role in the non-invasive treatment of atrial fibrillation with MRI-guided radiosurgery. In addition, to show how quantifiable measures of tracking accuracy and patient-specific physiology could influence MRI tracking algorithm design. METHODS: Twenty virtual patients were subjected to simulated MRI scans that closely model the proposed real-world scenario to allow verification of the tracking technique's algorithm...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29466218/-structural-and-functional-properties-of-the-left-atrium-in-healthy-volunteers-and-patients-with-atrial-fibrillation-data-of-magnetic-resonance-imaging
#4
O V Stukalova, N A Mironova, S P Golitsyn, O P Aparina, D V Parkhomenko, E Y Strazdenj, S K Ternovoy
BACKGROUND: in the recent years, there has been an increasing number of publications postulating that data on left atrial (LA) structure obtained by late gadolinium enhancement magnetic resonance imaging (LGE MRI) can improve the management of patients with atrial fibrillation (AF). At the same time, similar data regarding healthy LA myocardium is limited. AIM: to assess structural and functional properties of LA in healthy volunteers (HV) using cardiac magnetic resonance (CMR) (including LGE MRI); to compare these properties in patients with AF and HV...
September 2017: Kardiologiia
https://www.readbyqxmd.com/read/29465201/-pulse-wave-transit-time-one-more-attempt-of-non-invasive-cardiac-output-measurement
#5
B A Akselrod, L A Tolstova, T A Pshenichniy, S V Fedulova
BACKGROUND: Estimated continuous cardiac output (esCCOTM) based on pulse wave transit time is one of alternative non-invasive CO measurement techniques. METHODS: Randomized study included 23 scheduled patients operated upon due to cardiovascular diseases. Cardiac index (CI) was measured Comparative analyses of esCCO and others CO measurement methods used intraoperative was carried out. In the first group (n = 9) esCCO was compared with transpulmonary thermodilution (PiCCO-plus); in the second group (n = 8) - with pulmonary artery thermodilution; in the third group (n = 6) - with transoesophageal echocardiography (velocity-time integral)...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29459794/impaired-cardiac-function-in-patients-with-multiple-sclerosis-by-comparison-with-normal-subjects
#6
Raluca Ileana Mincu, Stefania Lucia Magda, Sorina Mihaila, Maria Florescu, Diana Janina Mihalcea, Andreea Velcea, Adela Chiru, Cristina Tiu, Bogdan Ovidiu Popescu, Mircea Cinteza, Dragos Vinereanu
Multiple sclerosis (MS), neurologic disease affecting young population, may cause cardiovascular dysfunction, due to autonomous nervous dysfunction, physical invalidity, increased oxidative stress, and systemic inflammatory status. However, cardiovascular function is rarely evaluated in these patients. We assessed left and right ventricular (LV and RV) function by 2D, 3D, tissue Doppler, and speckle tracking echocardiography, and vascular function by remodeling, stiffness, and endothelial dysfunction parameters in patients with MS, compared to control subjects...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29459321/bioengineering-an-electro-mechanically-functional-miniature-ventricular-heart-chamber-from-human-pluripotent-stem-cells
#7
Ronald A Li, Wendy Keung, Timothy J Cashman, Peter C Backeris, Bryce V Johnson, Evan S Bardot, Andy O T Wong, Patrick K W Chan, Camie W Y Chan, Kevin D Costa
Tissue engineers and stem cell biologists have made exciting progress toward creating simplified models of human heart muscles or aligned monolayers to help bridge a longstanding gap between experimental animals and clinical trials. However, no existing human in vitro systems provide the direct measures of cardiac performance as a pump. Here, we developed a next-generation in vitro biomimetic model of pumping human heart chamber, and demonstrated its capability for pharmaceutical testing. From human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCM) embedded in collagen-based extracellular matrix hydrogel, we engineered a three-dimensional (3D) electro-mechanically coupled, fluid-ejecting miniature human ventricle-like cardiac organoid chamber (hvCOC)...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29453808/three-dimensional-printing-in-congenital-heart-disease-a-systematic-review
#8
REVIEW
Ivan Lau, Zhonghua Sun
Three-dimensional (3D) printing has shown great promise in medicine with increasing reports in congenital heart disease (CHD). This systematic review aims to analyse the main clinical applications and accuracy of 3D printing in CHD, as well as to provide an overview of the software tools, time and costs associated with the generation of 3D printed heart models. A search of different databases was conducted to identify studies investigating the application of 3D printing in CHD. Studies based on patient's medical imaging datasets were included for analysis, while reports on in vitro phantom or review articles were excluded from the analysis...
February 17, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29453592/patient-specific-registration-of-3d-ct-angiography-cta-with-x-ray-fluoroscopy-for-image-fusion-during-transcatheter-aortic-valve-implantation-tavi-increases-performance-of-the-procedure
#9
I Vernikouskaya, W Rottbauer, J Seeger, B Gonska, V Rasche, Jochen Wöhrle
OBJECTIVES: The aim of this study was to adapt patient-specifically a co-registration procedure for image fusion (IF) of a pre-interventional CT dataset with real-time X-ray (XR) fluoroscopy during transfemoral transcatheter aortic valve implantation (TAVI), enabling improved performance of the procedure. BACKGROUND: The ability to use 3D models of the respective anatomies to complement the anatomic information obtained by XR fluoroscopy and provide a greater degree of real-time anatomical guidance holds great potential for complex cardiac interventions, especially for TAVI procedures with cerebral protection...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#10
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451120/an-in-silico-framework-to-analyze-the-anisotropic-shear-wave-mechanics-in-cardiac-shear-wave-elastography
#11
Annette Caenen, Mathieu Pernot, Mathias Peirlinck, Luc Mertens, Abigail Swillens, Patrick Segers
Shear wave elastography (SWE) is a potential tool to non-invasively assess cardiac muscle stiffness. This study focused on the effect of the orthotropic material properties and mechanical loading on the performance of cardiac SWE, as it is known that these factors contribute to complex 3D anisotropic shear wave propagation. To investigate the specific impact of these complexities, we constructed a finite element model with an orthotropic material law subjected to different uniaxial stretches to simulate SWE in the stressed cardiac wall...
February 16, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29440763/rhythm-an-open-source-imaging-toolkit-for-cardiac-panoramic-optical-mapping
#12
Christopher Gloschat, Kedar Aras, Shubham Gupta, N Rokhaya Faye, Hanyu Zhang, Roman A Syunyaev, Roman A Pryamonosov, Jack Rogers, Matthew W Kay, Igor R Efimov
Fluorescence optical imaging techniques have revolutionized the field of cardiac electrophysiology and advanced our understanding of complex electrical activities such as arrhythmias. However, traditional monocular optical mapping systems, despite having high spatial resolution, are restricted to a two-dimensional (2D) field of view. Consequently, tracking complex three-dimensional (3D) electrical waves such as during ventricular fibrillation is challenging as the waves rapidly move in and out of the field of view...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29427402/retrospective-multi-phase-non-contrast-enhanced-magnetic-resonance-angiography-romance-mra-for-robust-angiogram-separation-in-the-presence-of-cardiac-arrhythmia
#13
Hahnsung Kim, Suhyung Park, Eung Yeop Kim, Jaeseok Park
PURPOSE: To develop a novel, retrospective multi-phase non-contrast-enhanced MRA (ROMANCE MRA) in a single acquisition for robust angiogram separation even in the presence of cardiac arrhythmia. METHODS: In the proposed ROMANCE MRA, data were continuously acquired over all cardiac phases using retrospective, multi-phase flow-sensitive single-slab 3D fast spin echo (FSE) with variable refocusing flip angles, while an external pulse oximeter was in sync with pulse repetitions in FSE to record real-time information on cardiac cycles...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29425858/an-electrochemical-immunosensor-based-on-a-3d-carbon-system-consisting-of-a-suspended-mesh-and-substrate-bound-interdigitated-array-nanoelectrodes-for-sensitive-cardiac-biomarker-detection
#14
Deepti Sharma, Jongmin Lee, Heungjoo Shin
We developed an electrochemical redox cycling-based immunosensor using a 3D carbon system consisting of a suspended mesh and substrate-bound interdigitated array (IDA) nanoelectrodes. The carbon structures were fabricated using a simple, cost-effective, and reproducible microfabrication technology known as carbon microelectromechanical systems (C-MEMS). We demonstrated that the 3D sub-micrometer-sized mesh architecture and selective modification of the suspended mesh facilitated the efficient production of large quantities of electrochemical redox species...
February 3, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29422607/skeletal-myosin-binding-protein-c-isoforms-regulate-thin-filament-activity-in-a-ca2-dependent-manner
#15
Brian Leei Lin, Amy Li, Ji Young Mun, Michael J Previs, Samantha Beck Previs, Stuart G Campbell, Cristobal G Dos Remedios, Pieter de P Tombe, Roger Craig, David M Warshaw, Sakthivel Sadayappan
Muscle contraction, which is initiated by Ca2+, results in precise sliding of myosin-based thick and actin-based thin filament contractile proteins. The interactions between myosin and actin are finely tuned by three isoforms of myosin binding protein-C (MyBP-C): slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C and cMyBP-C, respectively), each with distinct N-terminal regulatory regions. The skeletal MyBP-C isoforms are conditionally coexpressed in cardiac muscle, but little is known about their function...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29416355/quantification-of-heart-pericardium-and-left-ventricular-myocardium-movements-during-the-cardiac-cycle-for-thoracic-tumor-radiotherapy
#16
Ying Tong, Yong Yin, Jie Lu, Tonghai Liu, Jinhu Chen, Pinjing Cheng, Guanzhong Gong
Purpose: The purpose of this study was to quantify variations in the heart, pericardium, and left ventricular myocardium (LVM) caused by cardiac movement using the breath-hold technique. Patients and methods: In this study, the electrocardiography-gated four-dimensional computed tomography (CT) images of 22 patients were analyzed, which were sorted into 20 phases (0-95%) according to the cardiac cycle. The heart, pericardium, and LVM were contoured on each phase of the CT images...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29416073/diagnostic-accuracy-of-three-dimensional-turbo-field-echo-magnetic-resonance-imaging-sequence-in-pediatric-tracheobronchial-anomalies-with-congenital-heart-disease
#17
QiaoRu Hou, Wei Gao, YuMin Zhong, AiMin Sun, Qian Wang, LiWei Hu, JingLei Wang
Tracheobronchial anomalies are common in congenital heart disease (CHD), including tracheobronchial stenosis, tracheal bronchus, cardiac bronchus, and bronchial isomerism, which can cause varying degrees of respiratory illness. It is necessary to assess tracheobronchial anomalies and make a preoperative airway evaluation. Multi-slice computed tomography (MSCT) and cardiac magnetic resonance imaging (MRI) are the most effective noninvasive modalities for the diagnosis of CHD and the associated tracheobronchial anomalies...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29412085/compliant-buckled-foam-actuators-and-application-in-patient-specific-direct-cardiac-compression
#18
Benjamin C Mac Murray, Chaim C Futran, Jeanne Lee, Kevin W O'Brien, Amir A Amiri Moghadam, Bobak Mosadegh, Meredith N Silberstein, James K Min, Robert F Shepherd
We introduce the use of buckled foam for soft pneumatic actuators. A moderate amount of residual compressive strain within elastomer foam increases the applied force ∼1.4 × or stroke ∼2 × compared with actuators without residual strain. The origin of these improved characteristics is explained analytically. These actuators are applied in a direct cardiac compression (DCC) device design, a type of implanted mechanical circulatory support that avoids direct blood contact, mitigating risks of clot formation and stroke...
February 2018: Soft Robotics
https://www.readbyqxmd.com/read/29409435/simulation-for-competency-assessment-in-vascular-and-cardiac-ultrasound
#19
Florence H Sheehan, R Eugene Zierler
Healthcare providers who use peripheral vascular and cardiac ultrasound require specialized training to develop the technical and interpretive skills necessary to perform accurate diagnostic tests. Assessment of competence is a critical component of training that documents a learner's progress and is a requirement for competency-based medical education (CBME) as well as specialty certification or credentialing. The use of simulation for CBME in diagnostic ultrasound is particularly appealing since it incorporates both the psychomotor and cognitive domains while eliminating dependency on the availability of live patients with a range of pathology...
February 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29409167/three-dimensional-printing-enhances-preparation-for-repair-of-double-outlet-right-ventricular-surgery
#20
Liyun Zhao, Sijie Zhou, Taibing Fan, Bin Li, Weijie Liang, Haoju Dong
OBJECTIVE: To assess the clinical value of three-dimensional (3D) printing technology for treatment strategies for complex double outlet right ventricle (DORV). METHODS: Twenty-five patients with complex double outlet right ventricle were enrolled in this study. The patients were divided into two groups: 3D printing group (eight patients) and a non-3-D printing control group (17 patients). The cardiac images of patients in the 3D printing group were transformed to Digital Imaging and Communications and were segmented and reconstructed to create a heart model...
January 2018: Journal of Cardiac Surgery
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