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https://www.readbyqxmd.com/read/28636811/performance-evaluation-of-gpu-parallelization-space-time-adaptive-algorithms-and-their-combination-for-simulating-cardiac-electrophysiology
#1
Rafael S Oliveira, Bernardo M Rocha, Denise Burgarelli, Wagner Meira, Christakis Constantinides, Rodrigo Weber Dos Santos
The use of computer models as a tool for the study and understanding of the complex phenomena of cardiac electrophysiology has attained increased importance nowadays. At the same time, the increased complexity of the biophysical processes translates into complex computational and mathematical models. In order to speed up cardiac simulations and to allow more precise and realistic uses, two different techniques have been traditionally exploited: parallel computing and sophisticated numerical methods. In this work, we combine a modern parallel computing technique based on multicore and graphics processing units (GPUs), and a sophisticated numerical method based on a new space-time adaptive algorithm...
June 21, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28625174/quantification-of-cardiomyocyte-alignment-from-three-dimensional-3d-confocal-microscopy-of-engineered-tissue
#2
William J Kowalski, Fangping Yuan, Takeichiro Nakane, Hidetoshi Masumoto, Marc Dwenger, Fei Ye, Joseph P Tinney, Bradley B Keller
Biological tissues have complex, three-dimensional (3D) organizations of cells and matrix factors that provide the architecture necessary to meet morphogenic and functional demands. Disordered cell alignment is associated with congenital heart disease, cardiomyopathy, and neurodegenerative diseases and repairing or replacing these tissues using engineered constructs may improve regenerative capacity. However, optimizing cell alignment within engineered tissues requires quantitative 3D data on cell orientations and both efficient and validated processing algorithms...
June 19, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28623910/pilot-study-using-3d-longitudinal-strain-computation-in-a-multi-parametric-approach-for-best-selecting-responders-to-cardiac-resynchronization-therapy
#3
Maxime Fournet, Anne Bernard, Sylvestre Marechaux, Elena Galli, Raphael Martins, Philippe Mabo, J Claude Daubert, Christophe Leclercq, Alfredo Hernandez, Erwan Donal
BACKGROUND: Almost all attempts to improve patient selection for cardiac resynchronization therapy (CRT) using echo-derived indices have failed so far. We sought to assess: the performance of homemade software for the automatic quantification of integral 3D regional longitudinal strain curves exploring left ventricular (LV) mechanics and the potential value of this tool to predict CRT response. METHODS: Forty-eight heart failure patients in sinus rhythm, referred for CRT-implantation (mean age: 65 years; LV-ejection fraction: 26%; QRS-duration: 160 milliseconds) were prospectively explored...
June 17, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28618338/markolab-a-simulator-to-study-ionic-channel-s-stochastic-behavior
#4
Robson Rodrigues da Silva, Daniel Gustavo Goroso, Donald M Bers, José Luis Puglisi
Mathematical models of the cardiac cell have started to include markovian representations of the ionic channels instead of the traditional Hodgkin & Huxley formulations. There are many reasons for this: Markov models are not restricted to the idea of independent gates defining the channel, they allow more complex description with specific transitions between open, closed or inactivated states, and more importantly those states can be closely related to the underlying channel structure and conformational changes...
June 12, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28614264/extremely-low-frame-rate-digital-fluoroscopy-in-catheter-ablation-of-atrial-fibrillation-a-comparison-of-2-versus-4-frame-rate
#5
Ji Hyun Lee, Jun Kim, Minsu Kim, Jongmin Hwang, You Mi Hwang, Joon-Won Kang, Gi-Byoung Nam, Kee-Joon Choi, You-Ho Kim
Despite the technological advance in 3-dimensional (3D) mapping, radiation exposure during catheter ablation of atrial fibrillation (AF) continues to be a major concern in both patients and physicians. Previous studies reported substantial radiation exposure (7369-8690 cGy cm) during AF catheter ablation with fluoroscopic settings of 7.5 frames per second (FPS) under 3D mapping system guidance. We evaluated the efficacy and safety of a low-frame-rate fluoroscopy protocol for catheter ablation for AF.Retrospective analysis of data on 133 patients who underwent AF catheter ablation with 3-D electro-anatomic mapping at our institute from January 2014 to May 2015 was performed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28612508/incremental-benefit-of-three-dimensional-transesophageal-echocardiography-in-the-assessment-of-a-primary-pericardial-hemangioma
#6
Mohammed J Arisha, Ming C Hsiung, Navin C Nanda, Ahmed ElKaryoni, Ahmed H Mohamed, Jeng Wei
Hemangiomas are rarely found in the heart and pericardial involvement is even more rare. We report a case of primary pericardial hemangioma, in which three-dimensional transesophageal echocardiography (3DTEE) provided incremental benefit over standard two-dimensional images. Our case also highlights the importance of systematic cropping of the 3D datasets in making a diagnosis of pericardial hemangioma with a greater degree of certainty. In addition, we also provide a literature review of the features of cardiac/pericardial hemangiomas in a tabular form...
June 13, 2017: Echocardiography
https://www.readbyqxmd.com/read/28608434/use-of-3d-models-of-vascular-rings-and-slings-to-improve-resident-education
#7
Trahern W Jones, Michael D Seckeler
OBJECTIVE: Three-dimensional (3D) printing is a manufacturing method by which an object is created in an additive process, and can be used with medical imaging data to generate accurate physical reproductions of organs and tissues for a variety of applications. We hypothesized that using 3D printed models of congenital cardiovascular lesions to supplement an educational lecture would improve learners' scores on a board-style examination. DESIGN AND INTERVENTION: Patients with normal and abnormal aortic arches were selected and anonymized to generate 3D printed models...
June 13, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28603000/validation-of-a-defibrillation-lead-ventricular-volume-measurement-compared-to-3d-echocardiography
#8
David E Haines, Wilson Wong, Robert Canby, Coty Jewell, Mahmoud Houmsse, David Pederson, Lissa Sugeng, John Porterfield, Anil Kottam, John Pearce, Jon Valvano, Joel Michalek, Aron Trevino, Sandeep Sagar, Marc D Feldman
BACKGROUND: There is increasing evidence that using frequent invasive measures of pressure in heart failure patients results in improved outcomes compared to traditional measures. Admittance, a measure of volume derived from pre-existing defibrillation leads is proposed as a new technique to monitor cardiac hemodynamics in patients with implantable defibrillators. OBJECTIVES: The goal of this work was to evaluate the accuracy of a new ventricular volume sensor (VVS, CardioVol), compared with 3D Echocardiography (echo) in patients with implantable defibrillators...
June 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28600860/estimating-the-accuracy-of-a-reduced-order-model-for-the-calculation-of-fractional-flow-reserve-ffr
#9
Etienne Boileau, Sanjay Pant, Carl Roobottom, Igor Sazonov, Jingjing Deng, Xianghua Xie, Perumal Nithiarasu
Image-based non-invasive fractional flow reserve (FFR) is an emergent approach to determine the functional relevance of coronary stenoses. The present work aimed to determine the feasibility of using a method based on coronary computed tomography angiography (CCTA) and reduced-order models (0D-1D) for the evaluation of coronary stenoses. The reduced-order methodology (cFFRro ) was kept as simple as possible and did not include pressure drop or stenosis models. The geometry definition was incorporated into the physical model used to solve coronary flow and pressure...
June 9, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28599827/late-detection-of-left-ventricular-dysfunction-using-two-dimensional-and-three-dimensional-speckle-tracking-echocardiography-in-patients-with-history-of-nonsevere-acute-myocarditis
#10
Thibault Caspar, Marie Fichot, Mickaël Ohana, Soraya El Ghannudi, Olivier Morel, Patrick Ohlmann
BACKGROUND: Acute myocarditis (AM) often involves the left ventricular (LV) subepicardium that might be displayed by cardiac magnetic resonance even late after the acute phase. In the absence of global or regional LV dysfunction, conventional transthoracic echocardiography (TTE) does not accurately identify tissue sequelae of AM. We sought to evaluate the diagnostic value of two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography to identify patients with a history of AM with preserved LV ejection fraction (LVEF)...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28595607/a-composite-visualization-method-for-electrophysiology-morphous-merging-of-human-heart
#11
Fei Yang, Lei Zhang, Weigang Lu, Yue Zhang, Wangmeng Zuo, Kuanquan Wang, Henggui Zhang
BACKGROUND: Electrophysiological behavior is of great importance for analyzing the cardiac functional mechanism under cardiac physiological and pathological condition. Due to the complexity of cardiac structure and biophysiological function, visualization of a cardiac electrophysiological model compositively is still a challenge. The lack of either modality of the whole organ structure or cardiac electrophysiological behaviors makes analysis of the intricate mechanisms of cardiac dynamic function a difficult task...
June 8, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28590127/interwoven-aligned-conductive-nanofiber-yarn-hydrogel-composite-scaffolds-for-engineered-3d-cardiac-anisotropy
#12
Yaobin Wu, Ling Wang, Baolin Guo, Peter X Ma
Mimicking the anisotropic cardiac structure and guiding 3D cellular orientation play a critical role in designing scaffolds for cardiac tissue regeneration. Significant advances have been achieved to control cellular alignment and elongation, but it remains an ongoing challenge for engineering 3D cardiac anisotropy using these approaches. Here, we present a 3D hybrid scaffold based on aligned conductive nanofiber yarns network (NFYs-NET, composition: polycaprolactone, silk fibroin, and carbon nanotubes) within a hydrogel shell for mimicking the native cardiac tissue structure, and further demonstrate their great potential for engineering 3D cardiac anisotropy for cardiac tissue engineering...
June 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28587156/differential-sarcomere-and-electrophysiological-maturation-of-human-ipsc-derived-cardiac-myocytes-in-monolayer-vs-aggregation-based-differentiation-protocols
#13
Dorota Jeziorowska, Vincent Fontaine, Charlène Jouve, Eric Villard, Sébastien Dussaud, David Akbar, Valérie Letang, Pauline Cervello, Jean-Michiel Itier, Marie-Pierre Pruniaux, Jean-Sébastien Hulot
Human induced pluripotent stem cells (iPSCs) represent a powerful human model to study cardiac disease in vitro, notably channelopathies and sarcomeric cardiomyopathies. Different protocols for cardiac differentiation of iPSCs have been proposed either based on embroid body formation (3D) or, more recently, on monolayer culture (2D). We performed a direct comparison of the characteristics of the derived cardiomyocytes (iPSC-CMs) on day 27 ± 2 of differentiation between 3D and 2D differentiation protocols with two different Wnt-inhibitors were compared: IWR1 (inhibitor of Wnt response) or IWP2 (inhibitor of Wnt production)...
June 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28574344/a-framework-for-the-generation-of-realistic-synthetic-cardiac-ultrasound-and-magnetic-resonance-imaging-sequences-from-the-same-virtual-patients
#14
Yitian Zhou, Sophie Giffard-Roisin, Mathieu De Craene, Sorina Camarasu-Pop, Jan D'hooge, Martino Alessandrini, Denis Friboulet, Maxime Sermesant, Olivier Bernard
The use of synthetic sequences is one of the most promising tools for advanced in silico evaluation of the quantification of cardiac deformation and strain through 3D ultrasound (US) and magnetic resonance (MR) imaging. In this paper, we propose the first simulation framework which allows the generation of realistic 3D synthetic cardiac US and MR (both cine and tagging) image sequences from the same virtual patient. A state-of-the-art electromechanical (E/M) model was exploited for simulating groundtruth cardiac motion fields ranging from healthy to various pathological cases including both ventricular dyssynchrony and myocardial ischemia...
May 25, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28568961/improved-respiratory-self-navigation-for-3d-radial-acquisitions-through-the-use-of-a-pencil-beam-2-d-t2-prep-for-free-breathing-whole-heart-coronary-mra
#15
Andrew J Coristine, Jerome Chaptinel, Giulia Ginami, Gabriele Bonanno, Simone Coppo, Ruud B van Heeswijk, Davide Piccini, Matthias Stuber
PURPOSE: In respiratory self-navigation (SN), signal from static structures, such as the chest wall, may complicate motion detection or introduce post-correction artefacts. Suppressing signal from superfluous tissues may therefore improve image quality. We thus test the hypothesis that SN whole-heart coronary magnetic resonance angiography (MRA) will benefit from an outer-volume suppressing 2D-T2 -Prep and present both phantom and in vivo results. METHODS: A 2D-T2 -Prep and a conventional T2 -Prep were used prior to a free-breathing 3D-radial SN sequence...
May 31, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28566818/three-dimensional-printed-cardiac-prototypes-aid-surgical-decision-making-and-preoperative-planning-in-selected-cases-of-complex-congenital-heart-diseases-early-experience-and-proof-of-concept-in-a-resource-limited-environment
#16
Mahesh Kappanayil, Nageshwara Rao Koneti, Rajesh R Kannan, Brijesh P Kottayil, Krishna Kumar
INTRODUCTION: Three-dimensional. (3D) printing is an innovative manufacturing process that allows computer-assisted conversion of 3D imaging data into physical "printouts" Healthcare applications are currently in evolution. OBJECTIVE: The objective of this study was to explore the feasibility and impact of using patient-specific 3D-printed cardiac prototypes derived from high-resolution medical imaging data (cardiac magnetic resonance imaging/computed tomography [MRI/CT]) on surgical decision-making and preoperative planning in selected cases of complex congenital heart diseases (CHDs)...
May 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28566200/performance-of-new-automated-transthoracic-three-dimensional-echocardiographic-software-for-left-ventricular-volumes-and-function-assessment-in-routine-clinical-practice-comparison-with-3%C3%A2-tesla-cardiac-magnetic-resonance
#17
Franck Levy, Elie Dan Schouver, Laura Iacuzio, Filippo Civaia, Stephane Rusek, Carinne Dommerc, Sylvestre Marechaux, Vincent Dor, Christophe Tribouilloy, Gilles Dreyfus
BACKGROUND: Three-dimensional (3D) transthoracic echocardiography (TTE) is superior to two-dimensional Simpson's method for assessment of left ventricular (LV) volumes and LV ejection fraction (LVEF). Nevertheless, 3D TTE is not incorporated into everyday practice, as current LV chamber quantification software products are time-consuming. AIMS: To evaluate the feasibility, accuracy and reproducibility of new fully automated fast 3D TTE software (HeartModel(A.I.); Philips Healthcare, Andover, MA, USA) for quantification of LV volumes and LVEF in routine practice; to compare the 3D LV volumes and LVEF obtained with a cardiac magnetic resonance (CMR) reference; and to optimize automated default border settings with CMR as reference...
May 26, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28562831/three-dimensional-volumetric-assessment-of-diastolic-function-by-cardiac-magnetic-resonance-imaging-the-multi-ethnic-study-of-atherosclerosis-mesa
#18
Marcelo S Nacif, Andre L C Almeida, Alistair A Young, Brett R Cowan, Anderson C Armstrong, Eunice Yang, Christopher T Sibley, W Gregory Hundley, Songtao Liu, Joao Ac Lima, David A Bluemke
Background: Cardiac Magnetic Resonance is in need of a simple and robust method for diastolic function assessment that can be done with routine protocol sequences. Objective: To develop and validate a three-dimensional (3D) model-based volumetric assessment of diastolic function using cardiac magnetic resonance (CMR) imaging and compare the results obtained with the model with those obtained by echocardiography. Methods: The study participants provided written informed consent and were included if having undergone both echocardiography and cine steady-state free precession (SSFP) CMR on the same day...
May 25, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28560509/evaluation-of-coronary-artery-disease-and-coronary-anomalies-with-a-handheld-smartphone
#19
Cheng Ting Lin, Stefan Loy Zimmerman, Linda C Chu, John Eng, Elliot K Fishman
The purpose of this study was to determine the diagnostic accuracy of an iPhone for evaluation of the coronary arteries on coronary CT angiography (CTA) in comparison to a standard clinical workstation. Fifty coronary CTA exams were selected to include a range of normal and abnormal cases including both coronary artery disease (CAD) of varying severity and coronary artery anomalies. Two cardiac radiologists reviewed each exam on a standard clinical workstation initially and then on an iPhone 6 after a washout period...
May 30, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28555593/3d-printed-models-in-patients-with-coronary-artery-fistulae-anatomical-assessment-and-interventional-planning
#20
María de Las Nieves Velasco Forte, Nick Byrne, Israel Valverde Perez, Aaron Bell, Gorka Gómez-Ciriza, Thomas Krasemann, Horst Sievert, John Simpson, Kuberan Pushparajah, Reza Razavi, Shakeel Qureshi, Tarique Hussain
AIMS: Coronary artery fistulae represent one of the most challenging anatomical defects to define accurately. We investigated the additional benefit conferred by volume-rendering of tomographic images and 3D-printing for diagnosis and interventional planning. METHODS AND RESULTS: Four cases of coronary fistulae were considered for transcatheter closure. Multidetector computed tomography (3 cases) or Cardiac Magnetic Resonance (1 case) images were acquired and segmented using Mimics software...
May 30, 2017: EuroIntervention
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