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https://www.readbyqxmd.com/read/28447859/transgene-expression-in-dogs-after-liver-directed-hydrodynamic-delivery-of-i-sleeping-beauty-i-transposons-using-balloon-catheters
#1
Kendra Anne Hyland, Elena L Aronovich, Erik R Olson, Jason B Bell, Myra Urness Rusten, Roland Gunther, David W Hunter, Perry B Hackett, R Scott McIvor
The <i>Sleeping Beauty</i> transposon system has been extensively tested for integration of reporter and therapeutic genes <i>in vitro</i> and <i>in vivo</i> in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solutions. DNA solutions were delivered into the entire liver or the left side of the liver using balloon catheters for temporary occlusion of venous outflow. A peak intravascular pressure between 80 and 140 mmHg supported sufficient DNA delivery in dog liver for detection of secretable reporter proteins...
April 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28435104/drosophila-pink1-and-parkin-loss-of-function-mutants-display-a-range-of-non-motor-parkinson-s-disease-phenotypes
#2
Hannah Julienne, Edgar Buhl, David S Leslie, James J L Hodge
Parkinson's disease (PD) is more commonly associated with its motor symptoms and the related degeneration of dopamine (DA) neurons. However, it is becoming increasingly clear that PD patients also display a wide range of non-motor symptoms, including memory deficits and disruptions of their sleep-wake cycles. These have a large impact on their quality of life, and often precede the onset of motor symptoms, but their etiology is poorly understood. The fruit fly Drosophila has already been successfully used to model PD, and has been used extensively to study relevant non-motor behaviours in other contexts, but little attention has yet been paid to modelling non-motor symptoms of PD in this genetically tractable organism...
April 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28434429/association-between-sleep-disordered-breathing-and-nighttime-driving-performance-in-mild-cognitive-impairment
#3
Nathan Cross, Zoe Terpening, Shantel L Duffy, Simon J G Lewis, Ron Grunstein, Keith Wong, Sharon L Naismith
OBJECTIVES: The effect of sleep disordered breathing (SDB) on driving performance in older adults has not been extensively investigated, especially in those with mild cognitive impairment (MCI). The aim of this study was to examine the relationship between severity measures of SDB and a simulated driving task in older adults with and without MCI. METHODS: Nineteen older adults (age ≥50) meeting criteria for MCI and 23 age-matched cognitively intact controls underwent neuropsychological assessment and a driving simulator task in the evening before a diagnostic sleep study...
April 24, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28434101/predicting-dream-recall-eeg-activation-during-nrem-sleep-or-shared-mechanisms-with-wakefulness
#4
Serena Scarpelli, Aurora D'Atri, Anastasia Mangiaruga, Cristina Marzano, Maurizio Gorgoni, Cinzia Schiappa, Michele Ferrara, Luigi De Gennaro
The common knowledge of a uniqueness of REM sleep as a privileged scenario of dreaming still persists, although consolidated empirical evidence shows that the assumption that dreaming is just an epiphenomenon of REM sleep is no longer tenable. However, the brain mechanisms underlying dream generation and its encoding in memory during NREM sleep are still mostly unknown. In fact, only few studies have investigated on the mechanisms of dream phenomenology related to NREM sleep. For this reason, our study is specifically aimed to elucidate the electrophysiological (EEG) correlates of dream recall (DR) upon NREM sleep awakenings...
April 22, 2017: Brain Topography
https://www.readbyqxmd.com/read/28431424/sleep-disordered-breathing-postoperative-delirium-and-cognitive-impairment
#5
Enoch W K Lam, Frances Chung, Jean Wong
Sleep-disordered breathing (SDB) is highly prevalent in the general population and has been associated with cognitive impairment in older individuals. Delirium is an acute decline in cognitive function and attention that often occurs after surgery, especially in older individuals. Several recent studies suggest an association between SDB and postoperative delirium. The aim of this systematic review is to examine the current literature on SDB, postoperative delirium, and cognitive impairment and to discuss the pathophysiology and perioperative considerations...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28422119/current-lifestyle-factors-that-increase-risk-of-t2dm-in-china
#6
REVIEW
N Zhang, S M Du, G S Ma
The Report on the Status of Nutrition and Chronic Diseases of Chinese residents (2015) indicated that the prevalence of diabetes was 9.7% among adults aged ⩾18 years, which markedly increased from 2.6% in 2002 within 10 years. In addition to the social economic factors, transitions in food consumption, behavioral and lifestyle playing the important roles in the fast increase of type 2 diabetes mellitus (T2DM). In 2010-2012, the cereal food consumption of Chinese residents was 337 g/d, vegetables consumption 269 g/d, fruit consumption 41 g/d, legume and legume products 11 g/d, dairy and dairy products consumption 25 g/d, meat consumption 90 g/d, edible oil consumption 42 g/d and dietary fiber 10...
April 19, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28419383/cell-death-biomarkers-and-obstructive-sleep-apnea-implications-in-the-acute-coronary-syndrome
#7
Josep Miquel Bauça, Aina Yañez, Laura Fueyo, Mónica de la Peña, Javier Pierola, Alicia Sánchez-de-la-Torre, Olga Mediano, Valentín Cabriada-Nuño, María José Masdeu, Joaquin Teran-Santos, Joaquin Duran-Cantolla, Juan Fernando Masa, Jorge Abad, Manuel Sanchez-de-la-Torre, Ferran Barbé, Antònia Barceló
Background: Nucleosomes and cell-free DNA (dsDNA) have been suggested as promising biomarkers in cell death-related diseases, such as acute coronary syndrome (ACS). Currently, the impact of obstructive sleep apnea (OSA) in patients with ACS is unclear. Our aim was to evaluate the relationship between OSA, dsDNA and nucleosomes, and to assess their potential implication in the development of ACS. Methods: Up to 549 patients were included in the study and divided into 4 groups (145 ACS; 290 ACS+OSA; 62 OSA; 52 controls)...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28418947/sleep-induced-apraxia-of-eyelid-opening
#8
Sara N Reggie, John J Chen, Michael S Lee, Sophia M Chung
BACKGROUND: Apraxia of eyelid opening (AEO) primarily has been described as bilateral loss of volitional ability to open the eyes at certain times and often associated with neurodegenerative disease. Rarely, it can occur in isolation and as an idiopathic phenomenon. There are a few reports of unilateral AEO only on awakening from sleep. We report an additional 11 patients with this unusual variation of AEO. METHODS: Retrospective, observational case series of patients collected from 3 separate neuro-ophthalmology practices...
April 14, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28416429/-life-threatening-sleepwalking-elpenor-s-syndrome-in-a-10-year-old-child
#9
M-A Madigand-Tordjman, P-J Egler, F Bertran, M Jokic, F Guénolé
Though benign in the majority of cases, sleepwalking sometimes causes injuries due, among other causes, to falls. Such accidents can be life-threatening - a situation that has been termed Elpenor syndrome (in reference to an accident experienced by a character in Homer's epic The Odyssey) - in particular when entailing defenestration. This syndrome has been described in adults and adolescents; we report here a case in a child. OBSERVATION: This 10-year-old girl was admitted at night to our hospital after a 3-m fall at home...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28413970/optimizing-the-management-of-uncontrolled-resistant-hypertension-the-importance-of-sleep-apnoea-syndrome
#10
Jacek Wolf, Krzysztof Narkiewicz
Obstructive sleep apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal blood pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causative role of OSA in the development of hypertension, the evidence is not fully consistent. Nasal continuous positive airway pressure (nCPAP) applied during sleep is well documented and a highly efficient therapeutic aid to eliminate OSA...
April 14, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28397756/anti-trypanosomatid-elemanolide-sesquiterpene-lactones-from-vernonia-lasiopus-o-hoffm
#11
Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt
Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples' lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid "protozoan" parasite Trypanosoma brucei. The parasites are transmitted to humans through bites of infected tsetse flies of the genus Glossina. The few available drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28392169/nonlinear-dynamical-analysis-of-sleep-electroencephalography-using-fractal-and-entropy-approaches
#12
REVIEW
Yan Ma, Wenbin Shi, Chung-Kang Peng, Albert C Yang
The analysis of electroencephalography (EEG) recordings has attracted increasing interest in recent decades and provides the pivotal scientific tool for researchers to quantitatively study brain activity during sleep, and has extended our knowledge of the fundamental mechanisms of sleep physiology. Conventional EEG analyses are mostly based on Fourier transform technique which assumes linearity and stationarity of the signal being analyzed. However, due to the complex and dynamical characteristics of EEG, nonlinear approaches are more appropriate for assessing the intrinsic dynamics of EEG and exploring the physiological mechanisms of brain activity during sleep...
January 29, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#13
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28385162/neuroligin-3-r451c-mutation-alters-electroencephalography-spectral-activity-in-an-animal-model-of-autism-spectrum-disorders
#14
Jackie J Liu, Kevin P Grace, Richard L Horner, Miguel A Cortez, Yiwen Shao, Zhengping Jia
Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitation/inhibition may contribute to various aspects of ASD, including sleep impairments. Following the identification of Nlgn3(R451C) mutation in patients with ASD, its effects on synaptic transmission and social behaviours have been examined extensively in the mouse model. However, the contributory role of this mutation to sleep impairments in ASD remains unknown...
April 7, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28371220/pain-correlates-with-sleep-disturbances-in-parkinson-s-disease-patients
#15
Yun-Ting Fu, Cheng-Jie Mao, Li-Jing Ma, Hui-Jun Zhang, Yi Wang, Jie Li, Jun-Ying Huang, Jun-Yi Liu, Chun-Feng Liu
OBJECTIVES: Both sleep disorders and pain decrease quality of life in Parkinson's disease (PD) patients. However, little is known about the relationship between objective sleep disturbances and pain in PD patients. This study aimed to (1) examine the clinical characteristics of pain in PD patients and (2) explore the correlation between pain and sleep disturbances in PD patients. METHODS: PD patients (N = 144) underwent extensive clinical evaluations of motor and nonmotor symptoms and characteristics of pain...
March 30, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28370491/extensions-to-bayesian-generalized-linear-mixed-effects-models-for-household-tuberculosis-transmission
#16
Avery I McIntosh, Gheorghe Doros, Edward C Jones-López, Mary Gaeddert, Helen E Jenkins, Patricia Marques-Rodrigues, Jerrold J Ellner, Reynaldo Dietze, Laura F White
Household contact studies, a mainstay of tuberculosis transmission research, often assume that tuberculosis-infected household contacts of an index case were infected within the household. However, strain genotyping has provided evidence against this assumption. Understanding the household versus community infection dynamic is essential for designing interventions. The misattribution of infection sources can also bias household transmission predictor estimates. We present a household-community transmission model that estimates the probability of community infection, that is, the probability that a household contact of an index case was actually infected from a source outside the home and simultaneously estimates transmission predictors...
March 29, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28364506/sleep-consolidates-motor-learning-of-complex-movement-sequences-in-mice
#17
Hirotaka Nagai, Luisa de Vivo, Michele Bellesi, Maria Felice Ghilardi, Giulio Tononi, Chiara Cirelli
Introduction: Sleep-dependent consolidation of motor learning has been extensively studied in humans, but it remains unclear why some, but not all, learned skills benefit from sleep. Aims and Methods: Here, we compared 2 different motor tasks, both requiring the mice to run on an accelerating device. In the rotarod task, mice learn to maintain balance while running on a small rod, while in the complex wheel task, mice run on an accelerating wheel with an irregular rung pattern...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364491/too-long-too-short-or-too-variable-sleep-intraindividual-variability-and-its-associations-with-perceived-sleep-quality-and-mood-in-adolescents-during-naturalistically-unconstrained-sleep
#18
Bei Bei, Rachel Manber, Nicholas B Allen, John Trinder, Joshua F Wiley
Introduction: Research has extensively examined the relationship between adolescents' mental health and average sleep duration/quality. Using rigorous methodology, this study characterized adolescents' objective sleep intraindividual variability (IIV) and examined its role on mood beyond the effects of their respective individual mean (IIM) values. Aims and Methods: One hundred forty-six community-dwelling adolescents (47.3% male) aged 16.2 ± 1.0 (M ± SD) years wore an actigraph that assessed bedtime, risetime, time-in-bed (TIB), and sleep onset latency (SOL) throughout a 15-day vacation with relatively unconstrained sleep opportunity...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28356131/treatment-of-infants-with-syndromic-robin-sequence-with-modified-palatal-plates-a-minimally-invasive-treatment-option
#19
Silvia Müller-Hagedorn, Wolfgang Buchenau, Jörg Arand, Margit Bacher, Christian F Poets
BACKGROUND: Infants with Robin sequence (RS) suffer from upper airway obstruction (UAO) and feeding problems. We developed an oral appliance with a velar extension in combination with functional treatment and appropriate feeding techniques, which was proven effective in isolated RS. As the above problems are particularly challenging in syndromic RS, we set out to evaluate our treatment concept also in these patients. METHODS: We searched our electronic departmental database to identify all children admitted to our department between 01/01/2003 and 31/12/2009 because of syndromic RS...
March 30, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/28328536/neurotransmission-systems-in-parkinson-s-disease
#20
Hossein Sanjari Moghaddam, Ameneh Zare-Shahabadi, Farzaneh Rahmani, Nima Rezaei
Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein particles, known as Lewy bodies. The second most common neurodegenerative disorder, PD is widely known because of the typical motor manifestations of active tremor, rigidity, and postural instability, while several prodromal non-motor symptoms including REM sleep behavior disorders, depression, autonomic disturbances, and cognitive decline are being more extensively recognized. Motor symptoms most commonly arise from synucleinopathy of nigrostriatal pathway...
March 22, 2017: Reviews in the Neurosciences
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