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https://www.readbyqxmd.com/read/29327337/generalized-nonmotor-absence-seizures-what-do-absence-generalized-and-nonmotor-mean
#1
REVIEW
Iris Unterberger, Eugen Trinka, Peter W Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer
OBJECTIVE: Clinical absences are now classified as "generalized nonmotor (absence) seizures" by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge. METHODS: For this narrative review we performed an extensive literature search on the term "absence," and analyzed the plethora of symptoms observed in clinical absences...
January 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29325791/the-therapeutic-effects-of-cannabis-and-cannabinoids-an-update-from-the-national-academies-of-sciences-engineering-and-medicine-report
#2
REVIEW
Donald I Abrams
The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committee's 11 prioritized health endpoints- therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances...
January 8, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29322350/monogenic-disorders-that-mimic-the-phenotype-of-rett-syndrome
#3
Siddharth Srivastava, Sonal Desai, Julie Cohen, Constance Smith-Hicks, Kristin Barañano, Ali Fatemi, SakkuBai Naidu
Rett syndrome (RTT) is caused by mutations in methyl-CpG-binding protein 2 (MECP2), but defects in a handful of other genes (e.g., CDKL5, FOXG1, MEF2C) can lead to presentations that resemble, but do not completely mirror, classical RTT. In this study, we attempted to identify other monogenic disorders that share features with RTT. We performed a retrospective chart review on n = 319 patients who had undergone clinical whole exome sequencing (WES) for further etiological evaluation of neurodevelopmental diagnoses that remained unexplained despite extensive prior workup...
January 10, 2018: Neurogenetics
https://www.readbyqxmd.com/read/29321122/technology-assisted-behavioral-intervention-to-extend-sleep-duration-development-and-design-of-the-sleep-bunny-mobile-app
#4
Kelly Glazer Baron, Jennifer Duffecy, Kathryn Reid, Mark Begale, Lauren Caccamo
BACKGROUND: Despite the high prevalence of short sleep duration (29.2% of adults sleep <6 hours on weekdays), there are no existing theory-based behavioral interventions to extend sleep duration. The popularity of wearable sleep trackers provides an opportunity to engage users in interventions. OBJECTIVE: The objective of this study was to outline the theoretical foundation and iterative process of designing the "Sleep Bunny," a technology-assisted sleep extension intervention including a mobile phone app, wearable sleep tracker, and brief telephone coaching...
January 10, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29316905/app-technology-to-increase-physical-activity-among-patients-with-diabetes-type-2-the-diacert-study-a-randomized-controlled-trial
#5
Stephanie E Bonn, Christina Alexandrou, Kristin Hjörleifsdottir Steiner, Klara Wiklander, Claes-Göran Östenson, Marie Löf, Ylva Trolle Lagerros
BACKGROUND: Physical activity can decrease the risk of complications related to diabetes type 2. Feasible and scalable strategies to implement support for a healthy lifestyle for patients in primary care are needed. The aim of the DiaCert-study is to evaluate a digital healthcare platform and the effect of a 12-week long smartphone-app physical activity intervention aiming at increasing physical activity (primary outcome) and improve levels of HbA1c (glycated hemoglobin), blood lipids, blood pressure, body composition, as well as other lifestyle factors and overall health in patients with diabetes type 2...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29307593/transcranial-near-infrared-photobiomodulation-attenuates-memory-impairment-and-hippocampal-oxidative-stress-in-sleep-deprived-mice
#6
Farzad Salehpour, Fereshteh Farajdokht, Marjan Erfani, Saeed Sadigh-Eteghad, Siamak Sandoghchian Shotorbani, Michael R Hamblin, Pouran Karimi, Seyed Hossein Rasta, Javad Mahmoudi
Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 hr. Simultaneously, NIR PBM using a laser at 810 nm was delivered (once a day for 3 days) transcranially to the head to affect the entire brain of mice. The Barnes maze and the What-Where-Which task were used to assess spatial and episodic-like memories...
January 4, 2018: Brain Research
https://www.readbyqxmd.com/read/29306892/association-of-body-flexibility-and-carotid-atherosclerosis-in-japanese-middle-aged-men-a-cross-sectional-study
#7
Masataka Suwa, Takayuki Imoto, Akira Kida, Takashi Yokochi, Mitsunori Iwase, Kenji Kozawa
OBJECTIVE: This study examined the associations of body flexibility with carotid arterial remodelling, including intima-media thickness (IMT) and plaque formation in middle-aged men. METHODS: The subjects of this cross-sectional study included 1354 Japanese men aged 35-59 years without histories of stroke or cardiac diseases. The arm extensibility test, which can estimate flexibility of the upper extremity (composed of shoulder external rotation and forearm supination), and the sit-and-reach test were performed...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29300329/reliability-aware-cooperative-node-sleeping-and-clustering-in-duty-cycled-sensors-networks
#8
Jeungeun Song, Yiming Miao, Enmin Song, M Shamim Hossain, Mohammed F Alhamid
Duty-cycled sensor networks provide a new perspective for improvement of energy efficiency and reliability assurance of multi-hop cooperative sensor networks. In this paper, we consider the energy-efficient cooperative node sleeping and clustering problems in cooperative sensor networks where clusters of relay nodes jointly transmit sensory data to the next hop. Our key idea for guaranteeing reliability is to exploit the on-demand number of cooperative nodes, facilitating the prediction of personalized end-to-end (ETE) reliability...
January 4, 2018: Sensors
https://www.readbyqxmd.com/read/29288546/the-impact-of-dental-caries-and-its-treatment-by-conventional-or-biological-approaches-on-the-oral-health-related-quality-of-life-of-children-and-carers
#9
Alaa BaniHani, Chris Deery, Jack Toumba, Theresa Munyombwe, Monty Duggal
BACKGROUND: The effect of untreated dental caries and the approaches taken to its treatment have not been extensively elucidated in children. AIM: To investigate the impact of untreated dental caries on children aged 4-9 years and whether its treatment with either a conventional or a biological approach influenced the oral health-related quality of life (OHRQoL) of the children and their carers. DESIGN: Children (n = 110) and their carers attending two specialist centres for treatment of carious primary teeth completed the Early Childhood Oral Health Impact Scale and the Self-reported Scale of Oral Health Outcomes for 5-year-old Children at baseline prior to dental treatment and at 3-6 months following completion of dental care...
December 30, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/29283409/omentin-a-novel-adipokine-in-respiratory-diseases
#10
REVIEW
Yan Zhou, Bo Zhang, Caixia Hao, Xiaoting Huang, Xiaohong Li, Yanhong Huang, Ziqiang Luo
Adipokines, secreted by the adipose tissue, are extensively involved in the regulation and maintenance of various physiological and pathological processes, including insulin sensitivity, energy expenditure, glucose and lipid metabolism, inflammatory activity, neuroendocrine activity, immunity, cancer, homeostasis, angiogenesis, cardiovascular function, breeding and bone metabolism, and all functions of the endocrine-reproductive system axis. Omentin is a recently identified adipokine, which has become a research hotspot due to its pleiotropic effects on various diseases...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282444/obstructive-sleep-apnea-presenting-as-non-epileptic-spells-a-unique-combination
#11
Prashant Natteru, Chintan Rupareliya, Xiangping Zhou, Pradeep C Bollu
Obstructive sleep apnea (OSA), an increasingly prevalent sleep disorder, has been extensively studied in both clinical and scientific settings. In most cases, the diagnosis of sleep apnea is straightforward with patients having symptoms of snoring, choking or gasping for air while asleep and witnessed apneas. However, sleep apnea is known to present in some unusual ways. We present a case of a 61-year-old male, with recently diagnosed obstructive sleep apnea (currently not on continuous positive airway pressure (CPAP)) and a history of seizure-like events since the age of 18 years, who came to the epilepsy monitoring unit (EMU) for spell characterization of his frequent seizure-like episodes...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29260906/gender-differences-in-sleep-habits-and-quality-and-daytime-sleepiness-in-elementary-and-high-school-teachers
#12
Jane Carla de Souza, Maria Luiza Cruz de Oliveira, Ivanise Cortez de Sousa, Carolina V M de Azevedo
The extensive workload of teachers inside and outside the classroom may contribute to sleep problems. Such problems may occur more frequently in women due to the combination of professional demands, domestic tasks, and their relatively greater sleep needs compared to men. The objective of this cross-sectional study was to evaluate the influence of gender on sleep habits and quality, and daytime sleepiness in a sample of 243 teachers (77 men and 166 women) using questionnaires. Linear regression models were used to examine the effect of gender on sleep measures; the unadjusted model considered only gender and the adjusted model considered chronotype and work characteristics as potential confounders...
December 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29238748/non-motor-symptoms-in-progressive-supranuclear-palsy-prevalence-and-severity
#13
Fabiana Giada Radicati, Pablo Martinez Martin, Chiara Fossati, Kallol Ray Chaudhuri, Margherita Torti, Carmen Rodriguez Blazquez, Laura Vacca, Fabrizio Stocchi
NMSs have been extensively studied in PD patients but not in other forms of parkinsonism such as Progressive Supranuclear Palsy (PSP). The primary objective of this study was to analyze the frequency, severity and the type of non-motor symptoms (NMS) in PSP patients using the non-motor symptoms scale (NMSS). The secondary objective was to differentiate NMS between PSP and Parkinson's disease (PD). We enrolled in this cross-sectional study 50 consecutive PSP and 100 matched Parkinson's disease (PD) patients, in the proportion PSP/PD = 1/2, matched in age, sex, and disease duration...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/29238576/a-case-of-legionella-pneumonia-caused-by-home-use-of-continuous-positive-airway-pressure
#14
Ruby Schnirman, Nasifa Nur, Alice Bonitati, Gerardo Carino
A 67-year-old woman with morbid obesity and severe obstructive sleep apnea presented to the emergency department with 2 days of productive cough, fever, shortness of breath and loose stools. A chest x-ray showed extensive bilateral infiltrates, and she was quickly intubated for acute hypoxic respiratory failure. A urine legionella antigen test was positive, and she was admitted to the intensive care unit with a diagnosis of severe legionella pneumonia. She improved over the next week with a course of levofloxacin...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29233612/association-between-long-sleep-duration-and-increased-risk-of-obesity-and-type-2-diabetes-a-review-of-possible-mechanisms
#15
REVIEW
Xiao Tan, Colin D Chapman, Jonathan Cedernaes, Christian Benedict
For the last two decades research has revealed an alarming association between short sleep duration and metabolic disorders. In tandem, the hormonal, behavioral, and genetic mechanisms underlying this relationship have been extensively investigated and reviewed. However, emerging evidence is revealing that excessive sleep duration has remarkably similar deleterious effects. Unfortunately, to date there has been little attention to what drives this connection. This narrative review therefore aims to summarize existing epidemiological findings, experimental work, and most importantly putative molecular and behavioral mechanisms connecting excessive sleep duration with both obesity and type 2 diabetes mellitus...
November 20, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29217495/efficacy-of-violet-oil-a-traditional-iranian-formula-in-patients-with-chronic-insomnia-a-randomized-double-blind-placebo-controlled-study
#16
Zohre Feyzabadi, Fariborz Rezaeitalab, Shapour Badiee, Ali Taghipour, Fatemeh Moharari, Atefeh Soltanifar, Mohammad Reza Ahmadpour
ETHNOPHARMACOLOGICAL RELEVANCE: Violet oil is an ancient herbal drug which has been extensively used to treat insomnia in traditional Iranian Medicine clinics. Violet oil is an almond or sesame oil-based extract of Viola odorata, which is administered as nasal drops. This study aimed to evaluate the efficacy of Violet oil in the treatment of insomnia. METHODS AND MATERIALS: This study was conducted as a 3-arm double-blind randomized trial. A total of 75 patients with chronic insomnia were enrolled and randomly assigned to three groups in Traditional Iranian Medicine Clinic of Mashhad University of Medical Sciences, Mashhad, Iran...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29204585/application-of-drug-induced-sleep-endoscopy-in-patients-treated-with-upper-airway-stimulation-therapy
#17
Adrian A Ong, Christopher M Ayers, Eric J Kezirian, B Tucker Woodson, Nico de Vries, Shaun A Nguyen, M Boyd Gillespie
Objective: To determine the level of agreement among experienced operators of candidacy for upper airway stimulation (UAS) based on evaluation of drug-induced sleep endoscopy (DISE). Methods: The trial was designed as a single-blinded cross-sectional study. Four otolaryngologists with extensive DISE experience were given 63 video clips from the STAR trial video library. These videos were graded using the VOTE classification. Percentage agreement and Cohen's κ (for inter-rater reliability) were calculated between pairs of reviewers, assessing palatal complete concentric collapse (CCC) and determining UAS eligibility...
June 2017: World journal of otorhinolaryngology—head and neck surgery
https://www.readbyqxmd.com/read/29197365/prevalence-of-severe-early-childhood-caries-and-associated-socioeconomic-and-behavioral-factors-in-xinjiang-china-a-cross-sectional-study
#18
Yan Li, Jibieke Wulaerhan, Yuan Liu, Ayinuer Abudureyimu, Jin Zhao
BACKGROUND: This study assessed the prevalence and severity of early childhood caries (ECC) and identified socioeconomic and behavioral correlates of the disease in preschool children living in Xinjiang. METHODS: For this cross-sectional survey, 1727 children aged 3-5 years in Xinjiang were randomly recruited using a three-stage cluster sampling procedure. The "dmft" index according to the WHO 1997 criteria was used to assess ECC and severe ECC (S-ECC). A questionnaire was completed by caregivers...
December 2, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29197172/sleep-patterns-predictive-of-daytime-challenging-behavior-in-individuals-with-low-functioning-autism
#19
Simonne Cohen, Ben D Fulcher, Shantha M W Rajaratnam, Russell Conduit, Jason P Sullivan, Melissa A St Hilaire, Andrew J K Phillips, Tobias Loddenkemper, Sanjeev V Kothare, Kelly McConnell, Paula Braga-Kenyon, William Ahearn, Andrew Shlesinger, Jacqueline Potter, Frank Bird, Kim M Cornish, Steven W Lockley
Increased severity of problematic daytime behavior has been associated with poorer sleep quality in individuals with autism spectrum disorder. In this work, we investigate whether this relationship holds in a real-time setting, such that an individual's prior sleep can be used to predict their subsequent daytime behavior. We analyzed an extensive real-world dataset containing over 20,000 nightly sleep observations matched to subsequent challenging daytime behaviors (aggression, self-injury, tantrums, property destruction and a challenging behavior index) across 67 individuals with low-functioning autism living in two U...
December 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29189154/brain-targeted-intranasal-zaleplon-nano-emulsion-in-vitro-characterization-and-assessment-of-gamma-aminobutyric-acid-levels-in-rabbits-brain-and-plasma-at-low-and-high-doses
#20
Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah
BACKGROUND: Zaleplon is a pyrazolopyrimidin derivative hypnotic drug indicated for the short-term management of insomnia. Zaleplon belongs to Class II drugs, according to the biopharmaceutical classification system (BCS), showing poor solubility and high permeability. It undergoes extensive first-pass hepatic metabolism after oral absorption, with only 30% of Zaleplon being systemically available. It is available in tablet form which is unable to overcome the previous problems. OBJECTIVE: The aim of this study is to enhance solubility and bioavailability via utilizing nanotechnology in the formulation of intranasal Zaleplon nano-emulsion (ZP-NE) to bypass the barriers and deliver an effective therapy to the brain...
November 30, 2017: Current Drug Delivery
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