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https://www.readbyqxmd.com/read/27913167/gamma-band-directional-interactions-between-basal-forebrain-and-visual-cortex-during-wake-and-sleep-states
#1
Jayakrishnan Nair, Arndt-Lukas Klaassen, Jordan Poirot, Alexei Vyssotski, Björn Rasch, Gregor Rainer
The basal forebrain (BF) is an important regulator of cortical excitability and responsivity to sensory stimuli, and plays a major role in wake-sleep regulation. While the impact of BF on cortical EEG or LFP signals has been extensively documented, surprisingly little is known about LFP activity within BF. Based on bilateral recordings from rats in their home cage, we describe endogenous LFP oscillations in the BF during quiet wakefulness, rapid eye movement (REM) and slow wave sleep (SWS) states. Using coherence and Granger causality methods, we characterize directional influences between BF and visual cortex (VC) during each of these states...
November 29, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27912882/tenuifolin-a-saponin-derived-from-radix-polygalae-exhibits-sleep-enhancing-effects-in-mice
#2
Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported that tenuifolin was a major constituent of polygalasaponins. PURPOSE: The currently study aims to investigate the hypnotic effect and possible mechanism of tenuifolin in freely moving mice...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27896626/cheyne-stokes-respiration-during-wakefulness-in-patients-with-chronic-heart-failure
#3
Wolfram Grimm, Karl Kesper, Werner Cassel, Nina Timmesfeld, Olaf Hildebrandt, Ulrich Koehler
PURPOSE: Cheyne-Stokes respiration (CSR) during sleep has been studied extensively in patients with chronic heart failure (CHF). Prevalence and prognostic significance of CSR during wakefulness in CHF, however, are largely unknown. METHODS: CSR during wakefulness with an apnea-hypopnea cut-off ≥5/h and moderate to severe CSR with an apnea-hypopnea cutoff ≥15/h were analyzed using polysomnographic recordings in 267 patients with stable CHF with reduced left ventricular (LV) ejection fraction at our institution...
November 28, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27855759/sleep-consolidates-motor-learning-of-complex-movement-sequences-in-mice
#4
Hirotaka Nagai, Luisa de Vivo, Michele Bellesi, Maria Felice Ghilardi, Giulio Tononi, Chiara Cirelli
STUDY OBJECTIVES: Sleep-dependent consolidation of motor learning has been extensively studied in humans, but it remains unclear why some, but not all learned skills benefit from sleep. METHODS: Here we compared 2 different motor tasks, both requiring the mice to run on an accelerating device. In the rotarod task mice learn to maintain balance while running on a small rod, while in the complex wheel task mice run on an accelerating wheel with an irregular rung pattern...
November 14, 2016: Sleep
https://www.readbyqxmd.com/read/27855757/too-long-too-short-or-too-variable-sleep-intraindividual-variability-and-its-associations-with-perceived-sleep-quality-and-mood-in-adolescents-during-naturalistically-unconstrained-sleep
#5
Bei Bei, Rachel Manber, Nicholas B Allen, John Trinder, Joshua F Wiley
STUDY OBJECTIVES: Research has extensively examined the relationship between adolescents' mental health and average sleep duration/quality. Using rigorous methodology, this study characterized adolescents' objective sleep intraindividual variability (IIV), and examined its role on mood beyond the effects of mean sleep parameters. METHODS: 146 community-dwelling adolescents (47.3% male) aged 16.2±1.0 (M±SD) years wore an actigraph that assessed bedtime, risetime, time-in-bed (TIB), and sleep onset latency (SOL) throughout a 15-day vacation with relatively unconstrained sleep opportunity...
November 14, 2016: Sleep
https://www.readbyqxmd.com/read/27846049/agomelatine-for-the-treatment-of-major-depressive-episodes-in-schizophrenia-spectrum-disorders-an-open-prospective-proof-of-concept-study
#6
Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Sarah Eisenacher, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Depressive episodes in schizophrenia constitute a major clinical problem, and treatment success is often limited by treatment-emergent side effects. Agomelatine, an agonist at melatonergic MT1/MT2 receptors and 5-HT2C receptor antagonist, is a new antidepressant with a novel mode of action which constitutes a potential therapeutic option for depression in schizophrenia. METHODS: Twenty-seven patients with lifetime diagnoses within the schizophrenia spectrum and comorbid depression were treated with agomelatine in addition to stable doses of antipsychotic agents...
October 29, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27829262/-upper-airway-stimulation-in-osa
#7
B Bender
Anatomical basis of obstructive sleep apnea (OSA) is the collapse of the pharynx during sleep. It is considered as a result of complex interactions of structural and neuromuscular factors. Depth of sleep and body position have modulating effects. Although different areas of obstruction were identified, studies show that the sleep-mediated obstruction frequently occurs in the base of tongue area.Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea syndrome (OSAS) since more than 30 years...
November 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/27823749/gender-differences-in-actual-and-preferred-nocturnal-sleep-duration-among-finnish-employed-population
#8
Päivi Polo-Kantola, Antti Laine, Erkki Kronholm, Maiju M Saarinen, Päivi Rautava, Minna Aromaa, Matti Sillanpää
OBJECTIVE: Sufficient sleep is essential for health and working capacity. Shorter sleep duration on workdays is often compensated by sleeping longer during leisure days. Gender dissimilarities in sleep quality are acknowledged. Our aim was to study the less known gender differences in sleep duration. METHODS: A population based study with a total of 1049 middle-aged regularly working women (n=524) and men (n=525). A questionnaire of sleep durations on workdays and leisure days, preferred sleep duration, with health-related quality of life and health behavior...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27821151/-i-ve-changed-my-mind-mindfulness-based-childbirth-and-parenting-mbcp-for-pregnant-women-with-a-high-level-of-fear-of-childbirth-and-their-partners-study-protocol-of-the-quasi-experimental-controlled-trial
#9
Irena K Veringa, Esther I de Bruin, Nancy Bardacke, Larissa G Duncan, Francisca J A van Steensel, Carmen D Dirksen, Susan M Bögels
BACKGROUND: Approximately 25 % of pregnant women suffer from a high level of Fear of Childbirth (FoC), as assessed by the Wijma Delivery Expectancy Questionnaire (W-DEQ-A, score ≥66). FoC negatively affects pregnant women's mental health and adaptation to the perinatal period. Mindfulness-Based Childbirth and Parenting (MBCP) seems to be potentially effective in decreasing pregnancy-related anxiety and stress. We propose a theoretical model of Avoidance and Participation in Pregnancy, Birth and the Postpartum Period in order to explore FoC and to evaluate the underlying mechanisms of change of MBCP...
November 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27810186/cortical-afferent-inhibition-reflects-cognitive-impairment-in-obstructive-sleep-apnea-syndrome-a-tms-study
#10
Raffaele Nardone, Jürgen Bergmann, Francesco Brigo, Yvonne Höller, Kerstin Schwenker, Cristina Florea, Alexander B Kunz, Stefan Golaszewski, Eugen Trinka
OBJECTIVES: Patients with obstructive sleep apnea syndrome (OSAS) show neurocognitive impairment, but the exact mechanisms that cause cognitive dysfunctions remain unknown. The cholinergic system is known to play a key role in all attentional processes and cognitive functions. A transcranial magnetic stimulation (TMS) protocol may give direct information about the function of some cholinergic circuits in the human brain; this technique relies on short latency afferent inhibition (SAI) of the motor cortex...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27810185/continuous-positive-airway-pressure-treatment-impact-on-memory-processes-in-obstructive-sleep-apnea-patients-a-randomized-sham-controlled-trial
#11
Marie Joyeux-Faure, Bernadette Naegelé, Jean-Louis Pépin, Renaud Tamisier, Patrick Lévy, Sandrine H Launois
OBJECTIVE: The aim of this study was to investigate the changes in a large panel of memory processes after six weeks of continuous positive airway pressure (CPAP) in obstructive sleep apnea (OSA) patients. This randomized controlled trial compared the influence of effective CPAP to sham CPAP over six weeks on different memory processes in OSA patients. METHODS: The study took place in a sleep laboratory and outpatient sleep clinic in a French tertiary-care university hospital...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27809820/effect-of-root-extracts-of-ficus-benghalensis-banyan-in-memory-anxiety-muscle-co-ordination-and-seizure-in-animal-models
#12
Dipesh Raj Panday, G P Rauniar
BACKGROUND: Ficus benghalensis L. (Banyan) is a commonly found tree in Eastern Nepal. Its different plant parts are used for various neurological ailments. This study was performed in mice to see its effects in various neuropharmacological parameters. METHODS: Passive-avoidance (memory), Open-field (anxiety), Pentobarbital-induced Sleep potentiation (sleep), Rota-rod (muscle-co-ordination), Pentylenetetrazol-Induced and Maximal Electroshock Seizure Tests were performed...
November 3, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27807620/genetic-background-of-enhanced-radioresistance-in-an-anhydrobiotic-insect-transcriptional-response-to-ionizing-radiations-and-desiccation
#13
Alina Ryabova, Kyosuke Mukae, Alexander Cherkasov, Richard Cornette, Elena Shagimardanova, Tetsuya Sakashita, Takashi Okuda, Takahiro Kikawada, Oleg Gusev
It is assumed that resistance to ionizing radiation, as well as cross-resistance to other abiotic stresses, is a side effect of the evolutionary-based adaptation of anhydrobiotic animals to dehydration stress. Larvae of Polypedilum vanderplanki can withstand prolonged desiccation as well as high doses of ionizing radiation exposure. For a further understanding of the mechanisms of cross-tolerance to both types of stress exposure, we profiled genome-wide mRNA expression patterns using microarray techniques on the chironomid larvae collected at different stages of desiccation and after exposure to two types of ionizing radiation-70 Gy of high-linear energy transfer (LET) ions ((4)He) and the same dose of low-LET radiation (gamma rays)...
November 2, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27805978/agomelatine-for-the-treatment-of-major-depressive-episodes-in-schizophrenia-spectrum-disorders-an-open-prospective-proof-of-concept-study
#14
Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Sarah Eisenacher, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Depressive episodes in schizophrenia constitute a major clinical problem, and treatment success is often limited by treatment-emergent side effects. Agomelatine, an agonist at melatonergic MT1/MT2 receptors and 5-HT2C receptor antagonist, is a new antidepressant with a novel mode of action which constitutes a potential therapeutic option for depression in schizophrenia. METHODS: Twenty-seven patients with lifetime diagnoses within the schizophrenia spectrum and comorbid depression were treated with agomelatine in addition to stable doses of antipsychotic agents...
December 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27797551/narcissism-and-response-validity-do-individuals-with-narcissistic-features-underreport-psychopathology
#15
Chelsea E Sleep, Martin Sellbom, W Keith Campbell, Joshua D Miller
Narcissism is broadly described as a grandiose sense of self, feelings of entitlement, and a need for attention and admiration. Theorists have long suggested that to maintain an overly positive self-image, individuals with narcissistic features often self-enhance (Leary, 2007) and exhibit distorted (John & Robins, 1994) self-perceptions. Despite this theoretical link, little is known about its relationship to response style, particularly in regard to underreporting or defensiveness. Nevertheless, response style has been extensively studied in psychopathy, narcissism's closest neighbor, due to concerns that psychopathic individuals may lack insight into their traits and/or may be unwilling to admit to perceived faults or difficulties...
October 31, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27792990/impact-of-benzodiazepines-on-brain-fdg-pet-quantification-after-single-dose-and-chronic-administration-in-rats
#16
Jesús Silva-Rodríguez, Lara García-Varela, Esteban López-Arias, Inés Domínguez-Prado, Julia Cortés, Juan Pardo-Montero, Anxo Fernández-Ferreiro, Álvaro Ruibal, Tomás Sobrino, Pablo Aguiar
INTRODUCTION: Current guidelines for brain PET imaging advice against the injection of diazepam prior to brain FDG-PET examination in order to avoid possible interactions of benzodiazepines with the radiotracer uptake. Nevertheless, many patients undergoing PET studies are likely to be under chronic treatment with benzodiazepines, for example due to the use of different medications such as sleeping pills. Animal studies may provide an extensive and accurate estimation of the effect of benzodiazepines on brain metabolism in a well-defined and controlled framework...
December 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27780990/association-of-interictal-epileptiform-discharges-with-sleep-and-anti-epileptic-drugs
#17
Latika Mohan, Jayvardhan Singh, Yogesh Singh, Rajesh Kathrotia, Arun Goel
BACKGROUND: The presence of interictal epileptiform discharges (IEDs) in electroencephalogram (EEG) is diagnostic of epilepsy. Latent IEDs are activated during sleep. Anti-epileptic drugs (AEDs) improve sleep. AEDs, sleep, and IEDs may interact and affect epilepsy management. PURPOSE: To explore the occurrence of IEDs and its association with sleep and AED status in suspected patients of epilepsy. METHODS: EEG records were collected of suspected patients of epilepsy who reported to the electrophysiology laboratory of a tertiary care hospital during 1 year...
October 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27775525/bayesian-nonnegative-cp-decomposition-based-feature-extraction-algorithm-for-drowsiness-detection
#18
Dong Qian, Bei Wang, Yun Qing, Tao Zhang, Yu Zhang, Xing Wang, Masatoshi Nakamura
Daytime short nap involves physiological processes, such as alertness, drowsiness and sleep. The study of the relationship between drowsiness and nap based on physiological signals is a great way to have a better understanding of the periodical rhymes of physiological states. A model of Bayesian nonnegative CP decomposition (BNCPD) was proposed to extract common multiway features from the group-level electroencephalogram (EEG) signals. As an extension of the nonnegative CP decomposition, the BNCPD model involves prior distributions of factor matrices, while the underlying CP rank could be determined automatically based on a Bayesian nonparametric approach...
October 19, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27755987/interictal-epileptiform-discharges-were-associated-with-poorer-cognitive-performance-in-adult-epileptic-patients
#19
Xiao-Ying Liu, Tao Shi, Wei-Na Yin, Zhen-Yu Ren, Yu-Lei Deng, Sheng-Di Chen
OBJECTIVE: Cognitive impairment is one of the major consequences of epilepsy and has been shown to reduce quality of life. Interictal epileptiform discharges (IEDs) were associated with poorer cognitive performance in children, and the aim of this study was to determine whether there was a similar association in adults. METHODS: A prospective cohort of 167 seizure-free adult patients underwent EEG recording and extensive cognitive evaluations. Global cognition was evaluated using Addenbrooke's Cognitive Examination-Revised (ACE-R), while sub-dimensions of cognition were evaluated using the Auditory Verbal Learning Test (AVLT), Trial Making Test (TMT)-A and -B, and the 5 constitutive subscales of ACE-R...
December 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27755472/physical-activity-to-overcome-the-adversity-of-widowhood-benefits-beyond-physical-health
#20
Chu-Shiu Li, June Han Lee, Chwen-Chi Liu, Yan-Lan Chan, Christopher Wen, Mu-Lin Chiu, Min Kuang Tsai, Shan Pou Tsai, Jackson Pui Man Wai, Chwen Keng Tsao, Xifeng Wu, Chi Pang Wen
Widowhood has been increasingly encountered because of increasing longevity of women, often characterized by social stigmatization and poor physical and mental health. However, applied research to overcome its adversity has been quite limited. The goal of this study is to explore the role of physical activity in improving the health of widows.A cohort of 446,582 adults in Taiwan who successively participated in a comprehensive medical screening program starting in 1994, including 232,788 women, was followed up for mortality until 2008...
August 2016: Medicine (Baltimore)
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