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https://www.readbyqxmd.com/read/29678161/an-unusually-high-frequency-of-scad-deficiency-caused-by-two-pathogenic-variants-in-the-acads-gene-and-its-relationship-to-the-ethnic-structure-in-slovakia
#1
Jana Lisyová, Ján Chandoga, Petra Jungová, Marcel Repiský, Mária Knapková, Martina Machková, Svetozár Dluholucký, Darina Behúlová, Jana Šaligová, Ľudmila Potočňáková, Miroslava Lysinová, Daniel Böhmer
BACKGROUND: Short-chain acyl-CoA dehydrogenase deficiency (SCADD) represents a rare autosomal recessive inborn metabolic disorder of mitochondrial β-oxidation of monocarboxylic acids. Clinical symptoms can vary from a severe life-threatening condition to an asymptomatic state, reported in the majority of cases. Since the expansion of newborn screenings, more than three hundred probands were admitted for molecular-genetic analysis, most selected because of elevated values of C4-acylcarnitine detected in newborn screenings in Slovakia...
April 20, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29650765/prospective-cardiovascular-genetics-evaluation-in-spontaneous-coronary-artery-dissection
#2
M Ihsan Kaadan, Carolyn MacDonald, Francesca Ponzini, Jessica Duran, Kelsey Newell, Linda Pitler, Angela Lin, Ido Weinberg, Malissa J Wood, Mark E Lindsay
BACKGROUND: Previous studies describing genetics evaluation in spontaneous coronary artery dissection (SCAD) have been retrospective in nature or presented as single case reports. As part of a dedicated clinical program, we evaluated patients in cardiovascular genetics clinic to determine the role of genetically triggered vascular disease and genetic testing in SCAD. METHODS AND RESULTS: Patient data were entered prospectively into the Massachusetts General Hospital SCAD registry database from July 2013 to September 2017...
April 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29643721/scalable-bayesian-variable-selection-using-nonlocal-prior-densities-in-ultrahigh-dimensional-settings
#3
Minsuk Shin, Anirban Bhattacharya, Valen E Johnson
Bayesian model selection procedures based on nonlocal alternative prior densities are extended to ultrahigh dimensional settings and compared to other variable selection procedures using precision-recall curves. Variable selection procedures included in these comparisons include methods based on g -priors, reciprocal lasso, adaptive lasso, scad, and minimax concave penalty criteria. The use of precision-recall curves eliminates the sensitivity of our conclusions to the choice of tuning parameters. We find that Bayesian variable selection procedures based on nonlocal priors are competitive to all other procedures in a range of simulation scenarios, and we subsequently explain this favorable performance through a theoretical examination of their consistency properties...
April 2018: Statistica Sinica
https://www.readbyqxmd.com/read/29618370/myeloperoxidase-level-and-inflammatory-markers-and-lipid-and-lipoprotein-parameters-in-stable-coronary-artery-disease
#4
Elżbieta Kimak, Bartosz Zięba, Dariusz Duma, Janusz Solski
BACKGROUND: Myeloperoxidase (MPO) impairing endothelial functions. We investigated whether increasing concentration of myeloperoxidase (MPO) and inflammatory markers induce progression and incident acute coronary syndrome (ACS) in stable coronary artery disease (SCAD) patients. Therefore, the concentration of MPO, lipids, lipoproteins (apo(apolipoprotein) AI, apoB, lipoprotein associated phospholipase A2 (LpPLA2) level), inflammatory markers (high sensitivity C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α), interleukine-6 (IL-6) concentration) were examined...
April 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29563379/rapid-healing-of-a-spontaneous-coronary-artery-dissection-detected-by-computed-tomography-angiography
#5
Koyu Sakai, Yohei Kobayashi, Shinichi Shirai, Kenji Ando
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and little is known about characteristics, treatment, and follow-up of patients with SCAD. Computed tomography angiography (CTA) plays an important role in the diagnosis and management of SCAD. Herein, we describe a case of a patient with SCAD who underwent successful conservative management, and in whom CTA was able to detect rapid healing of the dissection, 4.5 hours post-dissection.
March 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29549452/spontaneous-coronary-artery-dissection-diagnosis-and-management
#6
REVIEW
Ilhwan Yeo, Dmitriy N Feldman, Luke K Kim
PURPOSE OF REVIEW: Spontaneous coronary artery dissection (SCAD) is a non-iatrogenic and non-traumatic separation of the coronary arterial wall. While SCAD represents an important cause of myocardial infarction, optimal diagnostic and therapeutic options remain challenging. We sought to review recent studies and provide an update on diagnosis and management of SCAD. RECENT FINDINGS: Coronary angiography is the first-line diagnostic modality for SCAD, with three angiographic features commonly observed in SCAD: type 1 (pathognomonic angiographic appearance with contrast staining of the arterial wall), type 2 (long coronary stenosis), and type 3 (focal tubular stenosis)...
March 17, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29537415/sir-winston-churchill-treatment-for-pneumonia-in-1943-and-1944
#7
J A Vale, J W Scadding
This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29519241/clinical-and-genetic-characteristics-of-patients-with-fatty-acid-oxidation-disorders-identified-by-newborn-screening
#8
Eungu Kang, Yoon-Myung Kim, Minji Kang, Sun-Hee Heo, Gu-Hwan Kim, In-Hee Choi, Jin-Ho Choi, Han-Wook Yoo, Beom Hee Lee
BACKGROUND: Fatty acid oxidation disorders (FAODs) include more than 15 distinct disorders with variable clinical manifestations. After the introduction of newborn screening using tandem mass spectrometry, early identification of FAODs became feasible. This study describes the clinical, biochemical and molecular characteristics of FAODs patients detected by newborn screening (NBS) compared with those of 9 patients with symptomatic presentations. METHODS: Clinical and genetic features of FAODs patients diagnosed by NBS and by symptomatic presentations were reviewed...
March 8, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29502960/spontaneous-coronary-artery-dissection-and-takotsubo-syndrome-an-often-overlooked-association-review
#9
REVIEW
Shams Y-Hassan
Spontaneous coronary artery dissection (SCAD) and takotsubo syndrome (TS) are two cardiovascular syndromes with predilection for women. Both conditions may be preceded by an emotional stress or, for the affected individual, an unusual severe physical exercise. "Restitution ad integrum" occurs in most cases suffering from SCAD or TS with complete angiographic resolution of the dissected vessel and left ventricular dysfunction respectively. Recently, many cases, which were initially diagnosed as TS because of typical left ventricular ballooning pattern showed to have SCAD, have been reported; these cases were deemed to be "SCAD misdiagnosed as TS"...
February 8, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29489465/renin-angiotensin-system-blockade-reduces-cardiovascular-events-in-nonheart-failure-stable-patients-with-prior-coronary-intervention
#10
Young Choi, Sungmin Lim, Kwan Yong Lee, Ha-Wook Park, Jaeho Byeon, Byung-Hee Hwang, Jin Jin Kim, Yong-Seog Oh, Ho-Joong Youn, Wook Sung Jung, Ki-Bae Seung, Kiyuk Chang
BACKGROUND: The effects of renin-angiotensin system (RAS) blockade on the clinical outcome in patients with stable coronary artery disease (SCAD) are conflicting. We evaluated the long-term effects of RAS blockers (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker) on the clinical outcomes in patients with SCAD without heart failure (HF) who underwent percutaneous coronary intervention (PCI) with drug-eluting stent using a large-scale, multicenter, prospective cohort registry...
February 27, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29481627/european-society-of-cardiology-acute-cardiovascular-care-association-scad-study-group-a-position-paper-on-spontaneous-coronary-artery-dissection
#11
David Adlam, Fernando Alfonso, Angela Maas, Christiaan Vrints
No abstract text is available yet for this article.
February 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29478722/spontaneous-dissection-in-the-left-main-coronary-artery
#12
Peiren Shan, Weijian Huang, Rukhsaar Hoosen, Changzuan Zhou, Gary S Mintz, Guosheng Fu
We present two cases of spontaneous left main stem coronary artery dissection. One was underdiagnosed with suboptimal percutaneous coronary artery intervention followed by acute vessel occlusion again during the hospitalization. The other one was identified and confirmed by intravascular ultrasound, followed by conservative medical treatment, with completed healing of SCAD during two-month follow up.
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29474376/using-single-index-odes-to-study-dynamic-gene-regulatory-network
#13
Qi Zhang, Yao Yu, Jun Zhang, Hua Liang
With the development of biotechnology, high-throughput studies on protein-protein, protein-gene, and gene-gene interactions become possible and attract remarkable attention. To explore the interactions in dynamic gene regulatory networks, we propose a single-index ordinary differential equation (ODE) model and develop a variable selection procedure. We employ the smoothly clipped absolute deviation penalty (SCAD) penalized function for variable selection. We analyze a yeast cell cycle gene expression data set to illustrate the usefulness of the single-index ODE model...
2018: PloS One
https://www.readbyqxmd.com/read/29472380/spontaneous-coronary-artery-dissection-current-state-of-the-science-a-scientific-statement-from-the-american-heart-association
#14
REVIEW
Sharonne N Hayes, Esther S H Kim, Jacqueline Saw, David Adlam, Cynthia Arslanian-Engoren, Katherine E Economy, Santhi K Ganesh, Rajiv Gulati, Mark E Lindsay, Jennifer H Mieres, Sahar Naderi, Svati Shah, David E Thaler, Marysia S Tweet, Malissa J Wood
Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than previously believed but also must be evaluated and treated differently from atherosclerotic myocardial infarction...
February 22, 2018: Circulation
https://www.readbyqxmd.com/read/29467048/pregnancy-associated-spontaneous-coronary-artery-dissection-pascad-an-etiology-for-chest-pain-in-the-young-peripartum-patient
#15
Richard Lee, David Carr
Cardiac emergencies in pregnancy and the postpartum period are rare but often life-threatening. An emergency physician's differential diagnosis for chest pain in the peripartum patient often includes serious etiologies such as pulmonary embolism or myocardial infarction (MI). A lesser-known but important consideration on the differential for MI is that of a spontaneous coronary artery dissection (SCAD). SCAD is defined as an intramural hematoma within the coronary artery that compresses the true lumen. Expansion by increased pressures may lead to subsequent myocardial ischemia and infarction...
February 22, 2018: CJEM
https://www.readbyqxmd.com/read/29465109/in-carthage-ruins-the-illness-of-sir-winston-churchill-at-carthage-december-1943
#16
J A Vale, J W Scadding
This paper reviews Churchill's illness in Carthage in December 1943. It was characterised by fever that lasted 6 days, left lower lobe pneumonia and two episodes of atrial fibrillation. He was managed in a private villa by Lord Moran, his personal physician, with the assistance of two nurses and the expert advice of colleagues. Sulphadiazine and digitalis leaf were prescribed and Churchill recovered. It is remarkable that, despite the severity of his illness, he continued to direct the affairs of State from his bed...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29458232/fibrinogen-and-neopterin-is-associated-with-future-myocardial-infarction-and-total-mortality-in-patients-with-stable-coronary-artery-disease
#17
Øistein Rønneberg Mjelva, Gard F T Svingen, Eva K R Pedersen, Reinhard Seifert, Jan Terje Kvaløy, Øivind Midttun, Per M Ueland, Jan E Nordrehaug, Ottar Nygård, Dennis W T Nilsen
Systemic fibrinogen and neopterin are related to inflammation. We investigated the prognostic utility and possible interactions of these biomarkers in stable coronary artery disease (SCAD) patients undergoing coronary angiography. We included 3,545 patients with suspected stable angina with a median follow-up of 7.3 and 10.2 years for incident acute myocardial infarction (AMI) and all-cause mortality, respectively. Prospective associations were explored by Cox regression. Potential effect modifications were investigated according to strata of fibrinogen, neopterin or high-sensitivity troponin T (hsTnT) below and above the median, as well as gender and smoking habits...
February 19, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29446055/which-costs-matter-costs-included-in-economic-evaluation-and-their-impact-on-decision-uncertainty-for-stable-coronary-artery-disease
#18
James Lomas, Miqdad Asaria, Laura Bojke, Chris P Gale, Gerry Richardson, Simon Walker
BACKGROUND: Variation exists in the resource categories included in economic evaluations, and National Institute for Health and Care Excellence (NICE) guidance suggests the inclusion only of costs related to the index condition or intervention. However, there is a growing consensus that all healthcare costs should be included in economic evaluations for Health Technology Assessments (HTAs), particularly those related to extended years of life. OBJECTIVE AND METHODS: We aimed to quantify the impact of a range of cost categories on the adoption decision about a hypothetical intervention, and uncertainty around that decision, for stable coronary artery disease (SCAD) based on a dataset comprising 94,966 patients...
February 14, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29436932/john-guyett-scadding-s-scepticism-and-pragmatism-in-addressing-treatment-uncertainties-in-clinical-practice
#19
John W Scadding
No abstract text is available yet for this article.
February 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29434090/determinants-and-long-term-outcomes-of-percutaneous-coronary-interventions-vs-surgery-for-multivessel-disease-according-to-clinical-presentation
#20
Sung-Jin Hong, Byeong-Keuk Kim, Sanghoon Shin, Yongsung Suh, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND: The long-term outcome of percutaneous coronary intervention (PCI) vs. coronary artery bypass graft (CABG), particularly for patients with non-ST-elevation acute coronary syndrome (NSTE-ACS), remains controversial.Methods and Results:We retrospectively analyzed 2,827 patients (stable coronary artery disease [SCAD], n=1,601; NSTE-ACS, n=1,226) who underwent either PCI (n=1,732) or CABG (n=1,095). The 8-year composite of cardiac death and myocardial infarction (MI) was compared between PCI and CABG before and after propensity matching...
February 9, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
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