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https://www.readbyqxmd.com/read/29242257/atopobium-and-fusobacterium-as-novel-candidates-for-sarcoidosis-associated-microbiota
#1
Alexandra Zimmermann, Henrik Knecht, Robert Häsler, Gernot Zissel, Karoline I Gaede, Sylvia Hofmann, Almut Nebel, Joachim Müller-Quernheim, Stefan Schreiber, Annegret Fischer
Sarcoidosis is a granulomatous disease that mainly affects the lung. A role of microbial factors in disease pathogenesis is assumed, but has not been investigated systematically in a large cohort.This cross-sectional study compared the lung microbiota of 71 patients with sarcoidosis, 15 patients with idiopathic pulmonary fibrosis (non-infectious controls) and 10 healthy controls (HCs). Next-generation sequencing of 16S DNA was used on bronchoalveolar lavage samples to characterise the microbial composition, which was analysed for diversity and indicator species...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29234348/diurnal-transcriptome-and-gene-network-represented-through-sparse-modeling-in-brachypodium-distachyon
#2
Satoru Koda, Yoshihiko Onda, Hidetoshi Matsui, Kotaro Takahagi, Yukiko Yamaguchi-Uehara, Minami Shimizu, Komaki Inoue, Takuhiro Yoshida, Tetsuya Sakurai, Hiroshi Honda, Shinto Eguchi, Ryuei Nishii, Keiichi Mochida
We report the comprehensive identification of periodic genes and their network inference, based on a gene co-expression analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon. To reveal the diurnal changes in the transcriptome in B. distachyon, we performed RNA-seq analysis of its leaves sampled through a diurnal cycle of over 48 h at 4 h intervals using three biological replications, and identified 3,621 periodic genes through our wavelet analysis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29224120/spontaneous-cervical-artery-dissection-is-accompanied-by-a-hypercoagulable-state-and-simultaneous-inflammatory-condition
#3
Johann Otto Pelz, Kristian Harms, Michael Metze, Dominik Michalski
BACKGROUND: Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in sCAD patients. Thus, this study explores the association between the inflammatory and coagulation system in patients with sCAD. METHODS: The parameters leukocyte and thrombocyte count, C-reactive protein, fibrinogen, D-dimer, activated partial thromboplastin time (aPTT) and prothrombin time were extracted from hospital-based medical records of patients (n = 60) with sCAD and compared with those of a control group (n = 97) from a prospective observational stroke study...
December 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29209584/sudden-death-from-spontaneous-coronary-artery-dissection-due-to-polyarteritis-nodosa
#4
Cyrus M Munguti, Paul M Ndunda, Tabitha M Muutu
Spontaneous coronary artery dissection (SCAD) is an emerging and rare cause of acute coronary syndrome and sudden cardiac death. While it was previously reported among young females with fibromuscular dysplasia, new literature indicates that this condition could occur in older populations. Polyarteritis nodosa (PAN) causes systemic necrotizing vasculitis which typically affects small to medium-sized muscular arteries and could affect the coronary arteries. A few case reports of PAN causing acute coronary artery disease have been reported in the literature...
October 2, 2017: Curēus
https://www.readbyqxmd.com/read/29173612/a-case-of-spontaneous-coronary-artery-dissection-complicated-by-free-wall-rupture
#5
Hussain Alzayer, Matthias Bossard, Shoeb Ahsan, Michael Tsang, Richard Whitlock, Tej Sheth
Spontaneous coronary artery dissection (SCAD) is an unusual and underdiagnosed cause of nonatherosclerotic acute coronary syndrome (ACS). Patients might present in various ways including chest pain, ST-elevation ACS, ventricular arrhythmia, and sudden cardiac death. In a few reports, it manifested initially as cardiac tamponade. The association of SCAD with free wall rupture is extremely rare. We present a unique case of a 70-year-old woman who initially presented with non-ST elevation ACS and was found to have SCAD on angiography, which was subsequently complicated by cardiac tamponade with free wall rupture...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29171780/did-winston-churchill-suffer-a-myocardial-infarction-in-the-white-house-at-christmas-1941
#6
J Allister Vale, John W Scadding
While staying in the White House over Christmas 1941, Churchill developed chest pain on trying to open a window in his bedroom. Sir Charles Wilson, his personal physician, diagnosed a 'heart attack' (myocardial infarction). Wilson, for political and personal reasons, decided not to inform his patient of the diagnosis or obtain assistance from US medical colleagues. On Churchill's return to London, Wilson sought a second opinion from Dr John Parkinson who did not support the diagnosis of coronary thrombosis (myocardial infarction) and reassured Churchill accordingly...
January 1, 2017: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29146368/corrigendum-to-development-of-the-method-for-identification-of-selected-populations-of-torpedo-scad-megalaspis-cordyla-linnaeus-1758-using-microsatellite-dna-analyses-celfish-project-part-4-food-chem-221-2017-944-949
#7
Jolanta Kempter, Maciej Kielpiński, Remigiusz Panicz, Kaja Prüffer, Sławomir Keszka
No abstract text is available yet for this article.
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29128670/synchronous-immune-alterations-mirror-clinical-response-during-allergen-immunotherapy
#8
Amedee Renand, Mohamed H Shamji, Kristina M Harris, Tielin Qin, Erik Wambre, Guy W Scadding, Peter A Wurtzen, Stephen J Till, Alkis Togias, Gerald T Nepom, William W Kwok, Stephen R Durham
BACKGROUND: Three years treatment with either sublingual or subcutaneous allergen immunotherapy has been shown to be effective and to induce long-term tolerance. The GRASS(∗) trial demonstrated that two years treatment via either route was effective in suppressing the response to nasal allergen challenge, although was insufficient for inhibition one year after discontinuation. OBJECTIVE: To examine in the GRASS trial the time-course of immunologic changes during two years sublingual and subcutaneous immunotherapy and for one year after treatment discontinuation...
November 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29119361/associated-factors-of-self-rated-mental-health-status-in-southwestern-iran-using-scad-regression-model-in-a-population-based-study
#9
Najmeh Maharlouei, Fereshteh Kazemeini, Hadi Raeisi Shahraki, Kamran B Lankarani
This study aimed to investigate the association between self-rated mental health (SRMH) and current health status of an Iranian population. A cross-sectional study was conducted on 3400 individuals selected through random sampling in Shiraz, Iran between January 2014 and March 2015. Data were gathered through face-to-face interviews. Statistical analyses were performed using the SPSS 19.0, and R.3.1.2 software was used for SCAD penalized logistic regression. The mean age of the participants was 38.5 (± 14...
November 8, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29115576/genome-wide-dna-methylome-alterations-in-acute-coronary-syndrome
#10
Dandan Li, Jing Yan, Yunlong Yuan, Cheng Wang, Jia Wu, Qingwen Chen, Jiaxi Song, Junjun Wang
Acute coronary syndrome (ACS) is a common disease with high mortality and morbidity rates. The methylation status of blood DNA may serve as a potential early diagnosis and prevention biomarker for numerous diseases. The present study was designed to explore novel genome-wide aberrant DNA methylation patterns associated with ACS. The Infinium HumanMethylation450 assay was used to examine genome-wide DNA methylation profiles in 3 pairs of ACS and control group samples. Epigenome-wide DNA methylation, genomic distribution, Gene Ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29112183/leukotrienes-biosynthesis-in-coronary-artery-disease-results-of-leukotrienes-and-thromboxane-in-myocardial-infarction-ltimi-study
#11
Edyta Stodółkiewicz, Barbara Rewerska, Marcin Rzeszutko, Marek Tomala, Anton Chrustowicz, Krzysztof Żmudka, Marek Sanak, Wojciech Szczeklik
INTRODUCTION    Leukotrienes (LTs) play a potential role in atherosclerosis and may contribute to cardiovascular outcomes in coronary artery disease.  OBJECTIVES    1) to compare the baseline production of LTs in stable coronary artery disease (sCAD) and myocardial infarction (MI), and 2) assess whether increased production of LTs is associated with major adverse cardiovascular events (MACE) in one-year follow up from MI.  PATIENTS AND METHODS    LTIMI (Leukotrienes and Thromboxane In Myocardial Infarction) was single-center, prospective, observational study of patients with stable sCAD and MI...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29081176/-impact-of-platelet-distribution-width-on-the-extent-and-long-term-outcome-of-patients-with-stable-coronary-artery-disease-post-percutaneous-coronary-intervention
#12
P Jiang, Y Song, J J Xu, Y L Ma, X F Tang, Y Yao, L Jiang, H H Wang, X Zhang, X L Diao, Y J Yang, R L Gao, S B Qiao, B Xu, J Q Yuan
Objective: To evaluate the relationship between platelet distribution width(PDW) and the extent of coronary artery disease and 2-year outcome in patients received percutaneous coronary artery intervention(PCI) because of stable coronary artery disease(SCAD). Methods: We consecutively enrolled 4 293 patients who received PCI because of SCAD in Fuwai Hospital from Jan 2013 to Dec 2013, patients were followed up for 2 years. Patients were divided into three groups according to tertiles values of PDW as follows: PDW≤11...
October 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29078214/-non-st-segment-elevation-myocardial-infarction-caused-by-spontaneous-coronary-thrombosis-by-intimal-rupture
#13
Florian Kahles, Alexander Schuh, Michael Lehrke, Mathias Burgmaier, Nikolaus Marx, Sebastian Reith
Medical history We report on a 51-year-old male patient with thoracic pain of acute onset with radiation in the left arm. His cardiovascular risk factors include obesity, smoking and arterial hypertension. Investigations ECG showed no signs of ischemia. The blood test revealed increasing troponin (37 pg/ml; Norm < 14 pg/ml). Therefore we performed cardiac catheterization. The RIVA demonstrated a medial filling defect. Use of OCT imaging showed intimal rupture associated with thrombus. Treatment and course The lesion was stented with a drug eluting stent...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29064286/spontaneous-coronary-artery-dissection-challenges-of-diagnosis-and-management
#14
Mohamed A Ahmed, Mardi Hamra, Mohamed Ali, Abdullah S Abdullah, Samer Arnous, Thomas J Kiernan
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome in young patients. No clear factors exist to predict the natural history of the disease and the prognosis of the condition. Furthermore, current management practice of SCAD is based mainly on retrospective data and case series and clear management guidelines are lacking. In this article, we present a series of cases of patients with SCAD and we will discuss the different clinical presentations, the diagnostic approaches and the options of management of this cohort of patients...
November 2017: Future Cardiology
https://www.readbyqxmd.com/read/29046004/-coronary-computed-tomography-angiography-in-patients-with-stable-coronary-artery-disease
#15
Helen Ullrich, Tommaso Gori
The guidelines on the management of stable coronary artery disease (SCAD) recommend the use of coronary computed tomography angiography (CTA) in the process of diagnosing coronary artery disease in patients with low intermediate pre-test probability for SCAD. Particularly in cases where stress electrocardiogram or stress imaging provides unclear results, a computed tomographic examination can be considered as a reliable alternative to invasive coronary angiography. Due to its high negative predictive value, coronary CTA can provide accurate information on the presence of coronary artery stenosis and thus coronary artery disease can be reliably excluded without the risks associated with invasive procedures...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29031288/case-report-old-world-mucosal-leishmaniasis-report-of-five-imported-cases-to-the-hospital-for-tropical-diseases-london-united-kingdom
#16
Trupti A Patel, Glenis K Scadding, David E Phillips, Diana N Lockwood
Old World species of Leishmania typically cause visceral and cutaneous leishmaniasis. Mucosal involvement is typically seen with infection by Leishmania species found in South America, usually after the healing of cutaneous leishmaniasis. We present five imported cases of mucosal leishmaniasis caused by Old World Mediterranean Leishmania infantum exclusively affecting the nasal mucosa or vocal cord. In only one case was there a recollection of a preceding cutaneous lesion compatible with cutaneous Leishmaniasis...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29023996/effect-of-sex-difference-in-clinical-presentation-stable-coronary-artery-disease-vs-unstable-angina-pectoris-or-non-st-elevation-myocardial-infarction-vs-st-elevation-myocardial-infarction-on-2-year-outcomes-in-patients-undergoing-percutaneous-coronary-intervention
#17
Xiao-Fang Tang, Ying Song, Jing-Jing Xu, Yuan-Liang Ma, Jia-Hui Zhang, Yi Yao, Chen He, Huan-Huan Wang, Ping Jiang, Lin Jiang, Ru Liu, Zhan Gao, Xue-Yan Zhao, Shu-Bin Qiao, Bo Xu, Yue-Jin Yang, Run-Lin Gao, Jin-Qing Yuan
OBJECTIVE: To determine whether there is a difference in 2-year prognosis among patients across the spectrum of coronary artery disease undergoing percutaneous coronary intervention (PCI). METHODS: We analyzed all consecutive patients undergoing PCI at a single center from 1/1-12/31/2013. Clinical presentations were compared between sexes according to baseline clinical, angiographic, and procedural characteristics and 2-year (mean 730 ± 30-day) outcomes. RESULTS: We grouped 10 724 consecutive patients based on sex and clinical presentation...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28976224/a-sparse-qsrr-model-for-predicting-retention-indices-of-essential-oils-based-on-robust-screening-approach
#18
A M Al-Fakih, Z Y Algamal, M H Lee, M Aziz
A robust screening approach and a sparse quantitative structure-retention relationship (QSRR) model for predicting retention indices (RIs) of 169 constituents of essential oils is proposed. The proposed approach is represented in two steps. First, dimension reduction was performed using the proposed modified robust sure independence screening (MR-SIS) method. Second, prediction of RIs was made using the proposed robust sparse QSRR with smoothly clipped absolute deviation (SCAD) penalty (RSQSRR). The RSQSRR model was internally and externally validated based on [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], Y-randomization test, [Formula: see text], [Formula: see text], and the applicability domain...
August 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28940292/different-patients-different-outcomes-a-case-control-study-of-spontaneous-coronary-artery-dissection-versus-acute-coronary-syndrome
#19
Heath Adams, Elizabeth Paratz, Jithendra Somaratne, Jamie Layland, Andrew Burns, Sonny Palmer, Andrew MacIsaac, Robert Whitbourn
INTRODUCTION: There is progressive interest worldwide in spontaneous coronary artery dissection (SCAD). To identify a SCAD cohort and compare risk factors, presentation, and management outcomes compared to acute coronary syndrome (ACS) matched controls. METHODS: Retrospective analysis was performed from 2000 to 2015. Clinical data included a neuropsychiatric history, with management and clinical outcomes assessed at 12 months. Patients were matched on a 1:3 case-control basis according to type of ACS...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28927828/fatty-acid-oxidation-defects-presenting-as-primary-myopathy-and-prominent-dropped-head-syndrome
#20
Seena Vengalil, Veeramani Preethish-Kumar, Kiran Polavarapu, Rita Christopher, Narayanappa Gayathri, Archana Natarajan, Mahadevappa Manjunath, Saraswati Nashi, Chandrajit Prasad, Atchayaram Nalini
Fatty acid oxidation disorders presenting as primary myopathy is relatively rare and also diagnostically challenging. Its association with "dropped head syndrome" is reported till date in single cases of carnitine deficiency and multiple acyl CoA dehydrogenase deficiency (MADD).We studied nineteen cases of primary progressive myopathy confirmed to have fatty acid oxidation defects by Tandem Mass Spectrometry. The detailed clinical, muscle histopathology, tandem mass spectrometry and muscle magnetic resonance imaging (MRI) findings are presented here...
November 2017: Neuromuscular Disorders: NMD
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