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https://www.readbyqxmd.com/read/28199352/nearest-shrunken-centroids-via-alternative-genewise-shrinkages
#1
Byeong Yeob Choi, Eric Bair, Jae Won Lee
Nearest shrunken centroids (NSC) is a popular classification method for microarray data. NSC calculates centroids for each class and "shrinks" the centroids toward 0 using soft thresholding. Future observations are then assigned to the class with the minimum distance between the observation and the (shrunken) centroid. Under certain conditions the soft shrinkage used by NSC is equivalent to a LASSO penalty. However, this penalty can produce biased estimates when the true coefficients are large. In addition, NSC ignores the fact that multiple measures of the same gene are likely to be related to one another...
2017: PloS One
https://www.readbyqxmd.com/read/28197295/spontaneous-coronary-artery-dissection-the-phantom-menace
#2
Nikolaos Spinthakis, Nada Abdulkareem, Mohamed Farag, Diana A Gorog
We present a case of a 66-year-old lady with chest pain, without dynamic 12-lead electrocardiographic (ECG) changes and normal serial troponin. Coronary angiography revealed a linear filing defect in the first obtuse marginal branch of the circumflex artery indicating coronary artery dissection, with superadded thrombus. She was managed medically with dual antiplatelet therapy and has responded well. Spontaneous coronary artery dissection (SCAD) is a rare cause of cardiac chest pain, which can be missed without coronary angiography...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28196756/amberstripe-scad-decapterus-muroadsi-carangidae-fish-ingest-blue-microplastics-resembling-their-copepod-prey-along-the-coast-of-rapa-nui-easter-island-in-the-south-pacific-subtropical-gyre
#3
Nicolas Christian Ory, Paula Sobral, Joana Lia Ferreira, Martin Thiel
An increasing number of studies have described the presence of microplastics (≤5mm) in many different fish species, raising ecological concerns. The factors influencing the ingestion of microplastics by fish remain unclear despite their importance to a better understanding of the routes of microplastics through marine food webs. Here, we compare microplastics and planktonic organisms in surface waters and as food items of 20 Amberstripe scads (Decapterus muroadsi) captured along the coast of Rapa Nui (Easter Island) to assess the hypothesis that fish ingest microplastics resembling their natural prey...
February 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28196255/effect-of-2-years-of-treatment-with-sublingual-grass-pollen-immunotherapy-on-nasal-response-to-allergen-challenge-at-3-years-among-patients-with-moderate-to-severe-seasonal-allergic-rhinitis-the-grass-randomized-clinical-trial
#4
Guy W Scadding, Moises A Calderon, Mohamed H Shamji, Aarif O Eifan, Martin Penagos, Florentina Dumitru, Michelle L Sever, Henry T Bahnson, Kaitie Lawson, Kristina M Harris, Audrey G Plough, Joy Laurienzo Panza, Tielin Qin, Noha Lim, Nadia K Tchao, Alkis Togias, Stephen R Durham
Importance: Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. Objective: To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28185383/spontaneous-coronary-artery-dissection-and-takotsubo-syndrome-the-chicken-or-the-egg-causality-dilemma
#5
Shams Y-Hassan, Raquel Themudo, Eva Maret
Acute coronary syndrome (ACS) including spontaneous coronary artery dissection (SCAD) has been reported to trigger its own clinical twin takotsubo syndrome (TS). The pathogenetic association between SCAD and TS remains to be elucidated. The two diseases afflict predominantly women and both conditions may be triggered by an emotional stress factor and an unusual extreme physical exercise. Herein, we describe a case of 54-year-old woman presenting with ACS caused by an obtuso-marginal SCAD. Concurrently, the patient had typical clinical features and course of mid-apical pattern of TS...
February 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28168688/repeat-coronary-artery-dissection-in-pregnancy-a-case-report-and-review-of-the-literature
#6
Casey P Bitting, Ross E Zumwalt
Non-atherosclerotic spontaneous coronary artery dissection (NA-SCAD) is a rare cause of morbidity and mortality with a propensity for young, healthy, and often peripartum women. NA-SCAD etiology is poorly understood, with possible hormonal and hereditary mechanisms. Current treatment strategies range from conservative management (often showing resolution on angiographic follow-up) to invasive angiographic procedures. Rarely, NA-SCAD has recurred in another coronary artery, ranging hours to years later. We report NA-SCAD of the right coronary artery (RCA) in a 30-year old, 3-month postpartum female with an additional autopsy finding of remote myocardial infarction (MI) in the left anterior descending (LAD) coronary artery territory...
February 7, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28150519/ticagrelor-pharmacokinetics-and-pharmacodynamics-in-patients-with-nstemi-after-a-180-mg-loading-dose
#7
Manne Holm, Per Tornvall, Julia Westerberg, Shaym Rihan Hye, Jan van der Linden
The pharmacokinetics after a 180-mg loading dose (LD) of ticagrelor has not been thoroughly investigated in NSTEMI patients. We aimed to compare the ticagrelor uptake and on-treatment platelet reactivity between non-ST-segment elevation myocardial infarction (NSTEMI) patients and a control group of patients with stable coronary artery disease (SCAD) undergoing elective percutaneous coronary intervention. We performed an observational, prospective, single-center study including 40 NSTEMI patients and 20 SCAD controls...
February 2, 2017: Platelets
https://www.readbyqxmd.com/read/28141824/iterative-sure-independence-screening-em-bayesian-lasso-algorithm-for-multi-locus-genome-wide-association-studies
#8
Cox Lwaka Tamba, Yuan-Li Ni, Yuan-Ming Zhang
Genome-wide association study (GWAS) entails examining a large number of single nucleotide polymorphisms (SNPs) in a limited sample with hundreds of individuals, implying a variable selection problem in the high dimensional dataset. Although many single-locus GWAS approaches under polygenic background and population structure controls have been widely used, some significant loci fail to be detected. In this study, we used an iterative modified-sure independence screening (ISIS) approach in reducing the number of SNPs to a moderate size...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28139136/spontaneous-coronary-artery-dissection-challenges-of-coronary-computed-tomography-angiography
#9
Mackram F Eleid, Marysia S Tweet, Phillip M Young, Eric Williamson, Sharonne N Hayes, Rajiv Gulati
BACKGROUND: There is limited understanding of the role of cardiac computed tomography angiography (CCTA) for assessment of patients with spontaneous coronary artery dissection (SCAD). METHODS: In this report we describe the diagnostic utility of CCTA in three young women presenting with signs and symptoms of myocardial ischemia who were eventually diagnosed with SCAD. RESULTS: None of the women had traditional atherosclerotic risk factors...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28116866/angiographic-and-interventional-management-of-spontaneous-coronary-artery-dissections-when-less-is-more-or-when-better-flow-is-the-enemy-of-good-flow
#10
EDITORIAL
Malissa J Wood, Douglas E Drachman
Conservative management of SCAD in clinically stable patients with non-flow limiting lesions in major arteries is associated with favorable outcomes A careful, methodical approach to pursuing PCI in patients with SCAD is warranted Peripartum patients with SCAD appear to be at higher risk for technical complications; interventions in these patients should be performed by highly experienced operators.
January 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28101294/erratum-to-risk-and-safety-requirements-for-diagnostic-and-therapeutic-procedures-in-allergology-world-allergy-organization-statement
#11
Marek L Kowalski, Ignacio Ansotegui, Werner Aberer, Mona Al-Ahmad, Mubeccel Akdis, Barbara K Ballmer-Weber, Kirsten Beyer, Miguel Blanca, Simon Brown, Chaweewan Bunnag, Arnaldo Capriles Hulett, Mariana Castells, Hiok Hee Chng, Frederic De Blay, Motohiro Ebisawa, Stanley Fineman, David B K Golden, Tari Haahtela, Michael Kaliner, Connie Katelaris, Bee Wah Lee, Joanna Makowska, Ulrich Muller, Joaquim Mullol, John Oppenheimer, Hae-Sim Park, James Parkerson, Giovanni Passalacqua, Ruby Pawankar, Harald Renz, Franziska Rueff, Mario Sanchez-Borges, Joaquin Sastre, Glenis Scadding, Scott Sicherer, Pongsakorn Tantilipikorn, James Tracy, Vera van Kampen, Barbara Bohle, G Walter Canonica, Luis Caraballo, Maximiliano Gomez, Komei Ito, Erika Jensen-Jarolim, Mark Larche, Giovanni Melioli, Lars K Poulsen, Rudolf Valenta, Torsten Zuberbier
[This corrects the article DOI: 10.1186/s40413-016-0122-3.].
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28073362/elevated-levels-of-pre%C3%AE-1-high-density-lipoprotein-are-associated-with-cholesterol-ester-transfer-protein-the-presence-and-severity-of-coronary-artery-disease
#12
Xiao-Min Bu, Dong-Mei Niu, Jia Wu, Yun-Long Yuan, Jia-Xi Song, Jun-Jun Wang
BACKGROUND: Preβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable. METHODS: Preβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects...
January 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28038722/management-standards-for-stable-coronary-artery-disease-in-india
#13
Sundeep Mishra, Saumitra Ray, Jamshed J Dalal, J P S Sawhney, S Ramakrishnan, Tiny Nair, S S Iyengar, V K Bahl
Coronary artery disease (CAD) is one of the important causes of cardiovascular morbidity and mortality globally, giving rise to more than 7 million deaths annually. An increasing burden of CAD in India is a major cause of concern with angina being the leading manifestation. Stable coronary artery disease (SCAD) is characterised by episodes of transient central chest pain (angina pectoris), often triggered by exercise, emotion or other forms of stress, generally triggered by a reversible mismatch between myocardial oxygen demand and supply resulting in myocardial ischemia or hypoxia...
December 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/28017575/the-correlation-between-serum-total-bilirubin-and-outcomes-in-patients-with-different-subtypes-of-coronary-artery-disease
#14
Fang-Yang Huang, Yong Peng, Bao-Tao Huang, Yong Yang, Xiao-Bo Pu, Shi-Jian Chen, Yi-Yue Gui, Tian-Li Xia, Fei Chen, Rui-Shuang Liu, Ye Zhu, Mao Chen
BACKGROUNDS: The relation between serum total bilirubin (TBi) and mortality in patients with established coronary artery disease (CAD) remains undefined. We try to investigate the role of the subtypes of CAD in the association. METHODS: A total of 3013 patients with angiographically obstructive CAD were enrolled. A retrospective analysis was conducted. Patients were divided into 3 groups as follows: stable CAD (SCAD), unstable angina pectoris (UAP) and acute myocardial infarction (AMI)...
February 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28004756/alteration-of-platelet-gpvi-signaling-in-st-elevation-myocardial-infarction-patients-demonstrated-by-a-combination-of-proteomic-biochemical-and-functional-approaches
#15
Paula Vélez, Raymundo Ocaranza-Sánchez, Diego López-Otero, Lilian Grigorian-Shamagian, Isaac Rosa, Esteban Guitián, José María García-Acuña, José Ramón González-Juanatey, Ángel García
The platelet-specific collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis in vivo. We analyzed GPVI-activated platelets from ST-elevation myocardial infarction (STEMI) patients and matched stable coronary artery disease (SCAD) controls in order to provide novel clues on the degree of involvement of GPVI signaling in the acute event. Firstly, platelets were isolated from systemic venous blood and activated with the GPVI specific agonist CRP (collagen-related peptide)...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27988230/spontaneous-coronary-artery-dissection-still-a-lot-to-learn
#16
David Neves, Ângela Bento, Renato Fernandes, Lino Patrício, José Aguiar
Non-atherosclerotic spontaneous coronary artery dissection (SCAD) is an uncommon but probably underdetected pathological substrate for acute coronary syndrome. Clinical associations have been noted, like female gender and young age, but its pathophysiology is not yet fully understood. In this report we describe the case of a 50-year-old woman, without cardiovascular risk factors presenting with non-ST segment elevation myocardial infarction, in whom SCAD was diagnosed. Treatment was initially conservative but due to aggravation of the dissection she eventually underwent a complex percutaneous coronary intervention, requiring implantation of multiple stents, but with a good clinical outcome...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27986426/repeated-loss-of-consciousness-in-a-young-woman-a-suspicious-smad3-mutation-underlying-spontaneous-coronary-artery-dissection
#17
Míriam Garcia-Bermúdez, Abdel-Hakim Moustafa, Antonio Barrós-Membrilla, Helena Tizón-Marcos
Spontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndrome and is often underdiagnosed. Intramural hematoma is the most frequent angiographic presentation and is a challenging diagnosis that may require intravascular imaging techniques to confirm it and guide treatment. It affects mostly young women without coronary risk factors and is usually associated with fibromuscular dysplasia. SCAD has an underlying disease in 80% of patients. A SMAD3 mutation has been linked to aneurysm-osteoarthritis syndrome and has been identified as a cause of familial thoracic aortic aneurysm and dissection...
September 24, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27979298/development-of-the-method-for-identification-of-selected-populations-of-torpedo-scad-megalaspis-cordyla-linnaeus-1758-using-microsatellite-dna-analyses-celfish-project-part-4
#18
Kempter Jolanta, Kielpinski Maciej, Panicz Remigiusz, Kaja Prüffer, Keszka Sławomir
Catch and consumption of torpedo scad (Megalaspis cordyla) over the western Indian Ocean, but also the western Pacific from Japan to Australia is constantly increasing. Taking into account the degree of exploitation and missing information on the population structure of torpedo scad stocks it is crucial to provide population data. The analysis included individuals obtained in 2012 and 2013 from local markets in Madagascar, Tanzania, Vietnam and Cambodia and after successful DNA extraction fragment of the nuclear rhodopsin gene (RH1) and 9 microsatellite regions (SSRs) were amplified and analysed...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973331/how-and-when-to-suspect-spontaneous-coronary-artery-dissection-novel-insights-from-a-single-center-series-on-prevalence-and-angiographic-appearance
#19
Pascal Motreff, Guilhem Malcles, Nicolas Combaret, Nicolas Barber-Chamoux, Sara Bouajila, Bruno Pereira, Aime Amonchot, Bernard Citron, Jean-René Lusson, Romain Eschalier, Geraud Souteyrand
AIMS: Spontaneous coronary artery dissection (SCAD) is an under-diagnosed entity of acute coronary syndrome (ACS); its prevalence remains unclear due to a challenging diagnosis, particularly in instances of intramural hematoma without intimal rupture. METHODS AND RESULTS: From 1999 to 2014, 55 SCAD (all women, mean age 50.1 years) were diagnosed. Regardless of age, 51 (92.7%) had ≤2 cardiovascular risk factors. Thirty-six were diagnosed prospectively during the latter period (2012-2014)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27931279/mp-azeflu-provides-rapid-and-effective-allergic-rhinitis-control-in-real-life-a-pan-european-study
#20
Ludger Klimek, Claus Bachert, Par Stjrne, Ralph Dollner, Petter Larsen, Peter Haahr, Ioana Agache, Glenis Scadding, David Price
BACKGROUND: The European Union has prioritized allergic rhinitis (AR) control. Contre les Maladies Chronique pour un Vieillissement Actif Allergic Rhinitis and its Impact on Asthma has endorsed the visual analog scale (VAS) as the AR control language and incorporated it into a new AR treatment algorithm. Concurrently, the Respiratory Effectiveness Group and the European Academy of Allergy and Clinical Immunology are striving to improve the quality of published real-life AR research. Our aim was to assess the effectiveness of MP-AzeFlu by using a VAS in a well-designed, real-life, pan-European study...
September 2016: Allergy and Asthma Proceedings:
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