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swedish reflux trial

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https://www.readbyqxmd.com/read/27889221/the-swedish-infant-high-grade-reflux-trial-study-presentation-and-vesicoureteral-reflux-outcome
#1
Josefin Nordenström, Gundela Holmdahl, Per Brandström, Rune Sixt, Eira Stokland, Ulla Sillén, Sofia Sjöström
INTRODUCTION: High-grade vesicoureteral reflux (VUR) in infants is associated with congenital renal abnormalities, recurrent UTI, and bladder dysfunction. Endoscopic treatment (ET) is a well-established method in children with low to moderate reflux grades, but there is a lack of randomised controlled trials regarding the use of ET versus continuous antibiotic prophylaxis in infants with high-grade VUR. OBJECTIVE: This study aimed to determine whether high-grade VUR in infants can be treated with endoscopic injection and whether ET is superior to antibiotic prophylaxis in the treatment of VUR...
October 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/22784770/re-the-swedish-reflux-trial-review-of-a-randomized-controlled-trial-in-children-with-dilating-vesicoureteral-reflux
#2
EDITORIAL
Douglas A Canning
No abstract text is available yet for this article.
August 2012: Journal of Urology
https://www.readbyqxmd.com/read/22647800/impact-of-an-active-patient-education-program-on-gastrointestinal-symptoms-in-women-with-celiac-disease-following-a-gluten-free-diet-a-randomized-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Lisa Ring Jacobsson, Maria Friedrichsen, Anne Göransson, Claes Hallert
Despite living with a gluten-free diet, Swedish women with celiac disease report a higher rate of gastrointestinal symptoms than women without the disease. This study was designed to assess the impact of active patient education on gastrointestinal symptoms in women with a gluten-free diet. A total of 106 Swedish women, aged 20 years or older, with celiac disease on a gluten-free diet for a minimum of 5 years took part in a randomized controlled trial. The intervention group (n = 54) underwent a 10-session educational program, "Celiac School," based on problem-based learning...
May 2012: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/22619135/vesicoureteric-reflux-vur-in-children-where-are-we-now
#4
REVIEW
K Slabbaert, G Bogaert
In 1960 Hodson and Edwards published their landmark paper about the association between chronic pyelonefritis and vesicoureteric reflux (VUR). Since then, the approach for VUR became more important (1). In the last 30 years there have been multiple publications on vesicoureteric reflux (VUR) and discussions at Pediatric Urology meetings with the purpose to give answers to the questions what the best treatment is for VUR, at what age the treatment is advocated, does it prevent for febrile urinary tract infections (UTI's) and does it stop of decreases the risk for reflux nefropathy and renal scars Well known are the International Reflux Study (1981) with a European and an American arm in which the researchers compared medical approaches with surgical approaches to reflux, and the Birmingham Reflux study (1987) which was a prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children with five years observation (2)...
May 2012: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/22008041/parental-experiences-and-preferences-regarding-the-treatment-of-vesicoureteral-reflux
#5
RANDOMIZED CONTROLLED TRIAL
Tryggve Nevéus, Per Brandström, Tina Linnér, Ulf Jodal, Sverker Hansson
OBJECTIVE: Dilating vesicoureteral reflux (VUR) has been linked to febrile urinary tract infection (UTI) and renal scarring. It is unclear, however, whether children with reflux should be treated surgically or medically, or just kept under close surveillance with prompt treatment of UTIs. This lack of evidence makes parental preferences a crucial factor in the choice of therapy. The Swedish Reflux Trial was set up to compare the three treatment alternatives prospectively. This paper focuses on parental experience and satisfaction after completing the trial...
February 2012: Scandinavian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/21807562/the-swedish-reflux-trial-review-of-a-randomized-controlled-trial-in-children-with-dilating-vesicoureteral-reflux
#6
RANDOMIZED CONTROLLED TRIAL
Per Brandström, Ulf Jodal, Ulla Sillén, Sverker Hansson
OBJECTIVES: To evaluate prophylaxis and endoscopic injection for children with dilating vesicoureteral reflux (VUR) compared to surveillance, regarding urinary tract infection (UTI) recurrence, new renal damage, VUR outcome, and impact of lower urinary tract (LUT) dysfunction on these outcomes. PATIENTS AND METHODS: 203 children (128 girls and 75 boys), aged 1 to <2 years, with VUR grade III or IV were randomized to antibiotic prophylaxis (n = 69), endoscopic injection (n = 66) or surveillance (n = 68)...
December 2011: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/21618497/meta-analysis-of-two-randomized-controlled-trials-to-identify-long-term-symptoms-after-division-of-the-short-gastric-vessels-during-nissen-fundoplication
#7
C Engström, G G Jamieson, P G Devitt, D I Watson
BACKGROUND: Randomized trials suggest that division of the short gastric vessels during Nissen fundoplication is unnecessary. Some trials report an increased risk of gas bloat symptoms following division of the short gastric vessels. In this study long-term follow-up data from the two largest randomized clinical trials of division versus no division of the short gastric vessels during laparoscopic Nissen fundoplication were combined to determine whether there were differences in late outcome...
August 2011: British Journal of Surgery
https://www.readbyqxmd.com/read/20494369/the-swedish-reflux-trial-in-children-iv-renal-damage
#8
RANDOMIZED CONTROLLED TRIAL
Per Brandström, Tryggve Nevéus, Rune Sixt, Eira Stokland, Ulf Jodal, Sverker Hansson
PURPOSE: We compared the development of new renal damage in small children with dilating vesicoureteral reflux randomly allocated to antibiotic prophylaxis, endoscopic treatment or surveillance as the control group. MATERIALS AND METHODS: Included in the study were 128 girls and 75 boys 1 to younger than 2 years with grade III-IV reflux. Voiding cystourethrography and dimercapto-succinic acid scintigraphy were done before randomization and after 2 years. Febrile urinary tract infections were recorded during followup...
July 2010: Journal of Urology
https://www.readbyqxmd.com/read/20488494/the-swedish-reflux-trial-in-children-iii-urinary-tract-infection-pattern
#9
RANDOMIZED CONTROLLED TRIAL
Per Brandström, Elisabeth Esbjörner, Maria Herthelius, Svante Swerkersson, Ulf Jodal, Sverker Hansson
PURPOSE: We evaluated the difference in the febrile urinary tract infection rate in small children with dilating vesicoureteral reflux randomly allocated to 3 management alternatives, including antibiotic prophylaxis, endoscopic treatment or surveillance only as the control. MATERIALS AND METHODS: At 23 centers a total of 203 children were included in the study, including 128 girls and 75 boys 1 to younger than 2 years. Vesicoureteral reflux grade III in 126 cases and IV in 77 was detected after a febrile urinary tract infection (194) after prenatal screening (9)...
July 2010: Journal of Urology
https://www.readbyqxmd.com/read/20488486/the-swedish-reflux-trial-in-children-v-bladder-dysfunction
#10
RANDOMIZED CONTROLLED TRIAL
Ulla Sillén, Per Brandström, Ulf Jodal, Gundela Holmdahl, Anders Sandin, Ingrid Sjöberg, Sverker Hansson
PURPOSE: We investigated the prevalence and types of lower urinary tract dysfunction in children with vesicoureteral reflux grades III and IV, and related improved dilating reflux, renal damage and recurrent urinary tract infection to dysfunction. MATERIALS AND METHODS: A total of 203 children between ages 1 to less than 2 years with reflux grades III and IV were recruited into this open, randomized, controlled, multicenter study. Voiding cystourethrography and dimercapto-succinic acid scintigraphy were done at study entry and 2-year followup...
July 2010: Journal of Urology
https://www.readbyqxmd.com/read/20488469/the-swedish-reflux-trial-in-children-ii-vesicoureteral-reflux-outcome
#11
RANDOMIZED CONTROLLED TRIAL
Gundela Holmdahl, Per Brandström, Göran Läckgren, Ulla Sillén, Eira Stokland, Ulf Jodal, Sverker Hansson
PURPOSE: We compared reflux status in children with dilating vesicoureteral reflux treated in 3 groups, including low dose antibiotic prophylaxis, endoscopic therapy and a surveillance group on antibiotic treatment only for febrile urinary tract infection. MATERIALS AND METHODS: A total of 203 children 1 to younger than 2 years with grade III-IV reflux were recruited into this open, randomized, controlled trial. Endoscopic treatment was done with dextranomer/hyaluronic acid copolymer...
July 2010: Journal of Urology
https://www.readbyqxmd.com/read/20478580/the-swedish-reflux-trial-in-children-i-study-design-and-study-population-characteristics
#12
RANDOMIZED CONTROLLED TRIAL
Per Brandström, Elisabeth Esbjörner, Maria Herthelius, Gundela Holmdahl, Göran Läckgren, Tryggve Nevéus, Ulla Sillén, Rune Sixt, Ingrid Sjöberg, Eira Stokland, Ulf Jodal, Sverker Hansson
PURPOSE: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection. MATERIALS AND METHODS: Children 1 to younger than 2 years with grade III-IV reflux were recruited into this prospective, open, randomized, controlled, multicenter study and followed for 2 years after randomization...
July 2010: Journal of Urology
https://www.readbyqxmd.com/read/18447946/the-reflux-disease-questionnaire-a-measure-for-assessment-of-treatment-response-in-clinical-trials
#13
RANDOMIZED CONTROLLED TRIAL
Michael Shaw, John Dent, Timothy Beebe, Ola Junghard, Ingela Wiklund, Tore Lind, Folke Johnsson
BACKGROUND: Critical needs for treatment trials in gastroesophageal reflux disease (GERD) include assessing response to treatment, evaluating symptom severity, and translation of symptom questionnaires into multiple languages. We evaluated the previously validated Reflux Disease Questionnaire (RDQ) for internal consistency, reliability, responsiveness to change during treatment and the concordance between RDQ and specialty physician assessment of symptom severity, after translation into Swedish and Norwegian...
2008: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/16960663/an-antireflux-stent-versus-conventional-stents-for-palliation-of-distal-esophageal-or-cardia-cancer-a-randomized-clinical-study
#14
RANDOMIZED CONTROLLED TRIAL
U Wenger, E Johnsson, U Arnelo, L Lundell, J Lagergren
BACKGROUND: Self-expandable metal stents placed across the esophagogastric junction for palliative treatment of malignant strictures may lead to gastroesophageal reflux and pulmonary aspiration. This study compared the effects of a Dua antireflux stent with those of a conventional stent. METHODS: Patients with incurable cancer of the distal esophagus or gastric cardia were randomly assigned to receive an antireflux stent (n = 19) or a standard stent (n = 22) at nine Swedish hospitals during the period September 1, 2003 to July 31, 2005...
November 2006: Surgical Endoscopy
https://www.readbyqxmd.com/read/16405529/gastroesophageal-reflux-symptoms-and-well-being-in-a-random-sample-of-the-general-population-of-a-swedish-community
#15
COMPARATIVE STUDY
Ingela Wiklund, Jonas Carlsson, Nimish Vakil
OBJECTIVES: There is limited information on the relationship between gastroesophageal reflux symptoms and well-being in the general population. This study aimed to investigate this relationship and determine the severity threshold at which reflux symptoms meaningfully affect patients' well-being. METHODS: A random sample of the population of Malmö, Sweden (n = 4,624), was sent the Gastrointestinal Symptom Rating Scale, the Subjective Symptom Assessment Profile, and the Psychological General Well-Being Index...
January 2006: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/14516179/factor-structure-of-the-quality-of-life-in-reflux-and-dyspepsia-qolrad-questionnaire-evaluated-in-patients-with-heartburn-predominant-reflux-disease
#16
COMPARATIVE STUDY
Károly R Kulich, Ingela Wiklund, Ola Junghard
AIM: To test whether the original factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) can be replicated in Nordic patients and English speaking patients. PATIENTS AND METHODS: Clinical trial patients with heartburn without esophagitis completed the Swedish, Norwegian, Finnish and Danish versions (n = 634) and the English version (n = 1185). The factor structure was examined using models generated by exploratory and confirmatory factor analysis...
September 2003: Quality of Life Research
https://www.readbyqxmd.com/read/12194554/adjustable-gastric-and-esophagogastric-banding-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Helmut G Weiss, Hermann Nehoda, Burkard Labeck, Regina Peer-Kuehberger, Michael Oberwalder, Franz Aigner, Gerold J Wetscher
BACKGROUND: Adjustable gastric banding and esophagogastric banding may affect the function of the lower esophageal sphincter (LES) and esophageal motility in the long-term. Both methods were evaluated in a prospective randomized trial. MATERIALS AND METHODS: Group 1 comprised 28 patients who underwent laparoscopic adjustable gastric banding and Group 2 consisted of 24 patients in whom adjustable esophagogastric banding was performed. Swedish Adjustable Gastric Bands were used in all patients...
August 2002: Obesity Surgery
https://www.readbyqxmd.com/read/10588272/medical-or-surgical-management-for-children-with-vesico-ureteric-reflux
#18
REVIEW
U Jodal, S Hansson, K Hjälmås
A critical survey of the literature on treatment of children with vesico-ureteric reflux was carried out in order to create a basis for the new Swedish management policy. There are few studies that meet modern standards of scientific methodology and provide adequate patient numbers. The only large investigations that randomized patients to operative or non-operative treatment were the Birmingham Reflux Study and the International Reflux Study in Children. In these studies, long-term outcome of renal status and renal function, as well as the number of recurrent infections, were independent of treatment modality...
November 1999: Acta Paediatrica. Supplement
https://www.readbyqxmd.com/read/10146883/omeprazole-a-pharmacoeconomic-evaluation-of-its-use-in-duodenal-ulcer-and-reflux-oesophagitis
#19
REVIEW
L B Barradell, D McTavish
Omeprazole regulates gastric acid secretion and is an effective treatment of acute duodenal ulcer and reflux oesophagitis, achieving more rapid healing and symptomatic relief than histamine H 2-receptor antagonists. When administered as maintenance therapy, omeprazole reduces the incidence of relapse. The drug is also highly effective in patients poorly responsive to histamine H 2-receptor antagonists. The daily acquisition cost of omeprazole is higher than that of histamine H 2-receptor antagonists in many countries, and thus it is important to evaluate the pharmacoeconomic impact of omeprazole in the short and long term treatment of duodenal ulcer and reflux oesophagitis...
June 1993: PharmacoEconomics
https://www.readbyqxmd.com/read/9110389/relevance-of-norm-values-as-part-of-the-documentation-of-quality-of-life-instruments-for-use-in-upper-gastrointestinal-disease
#20
RANDOMIZED CONTROLLED TRIAL
E Dimenäs, G Carlsson, H Glise, B Israelsson, I Wiklund
This article presents the relevance of norm values to a battery of Quality of Life questionnaires for use in upper gastrointestinal disorders. The derivation of reference values offers an important contribution by confirming the ability of the questionnaires to differentiate patients from healthy controls. Two self-administered questionnaires, the Psychological General Well-being (PGWB) index and the Gastrointestinal Symptom Rating Scale (GSRS) were used. The norm values were derived in a randomly selected sample from a Swedish population consisting of 4624 individuals (reference group)...
1996: Scandinavian Journal of Gastroenterology. Supplement
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