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https://www.readbyqxmd.com/read/28716610/current-status-and-future-direction-of-biodegradable-metallic-and-polymeric-vascular-scaffolds-for-next-generation-stents
#1
REVIEW
Seung Hyuk Im, Youngmee Jung, Soo Hyun Kim
Because of the increasing incidence of coronary artery disease, the importance of cardiovascular stents has continuously increased as a treatment of this disease. Biodegradable scaffolds fabricated from polymers and metals have emerged as promising materials for vascular stents because of their biodegradability. Although such stent framework materials have shown good clinical efficacy, it is difficult to decide whether polymers or metals are better vascular scaffolds because their properties are different. Therefore, there are still obstacles in the development of biodegradable vascular scaffolds in terms of improving clinical efficacy...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28714525/dedicated-bifurcation-stents-or-regular-drug-eluting-stents-in-distal-left-main-stenosis-a-retrospective-study
#2
Adam Kern, Robert J Gil, Krystian Bojko, Bartłomiej Rzeszowski, Krzysztof Bednarski, Jerzy Górny, Jacek Bil
BACKGROUND: Mainly atherosclerosis develops in distal left main (LM) within bifurcation or trifurcation. The aim of this study was to analyze the strategy of distal LM stenosis treatment and associated clinical outcomes in a large hospital in Northern Poland. METHODS: The study population consisted of consecutive patients with stable coronary artery disease or acute coronary syndrome (ACS) and distal LM stenosis who were hospitalized between June 2012 and June 2013...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28707440/everolimus-eluting-bioresorbable-vascular-scaffolds-can-we-absorb-the-risk-in-complex-pci
#3
EDITORIAL
Firas Zahr, Joaquin E Cigarroa
BVS, as compared with DES, have higher stent thrombosis (ST) rates. BVS may prove reasonable in patients with complex anatomy. Future trials will be necessary to guide clinicians regarding whether BVS are equivalent to DES in patients with noncomplex or complex coronary anatomy.
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28705512/multi-objective-optimization-of-nitinol-stent-design
#4
G Alaimo, F Auricchio, M Conti, M Zingales
Nitinol stents continuously experience loadings due to pulsatile pressure, thus a given stent design should possess an adequate fatigue strength and, at the same time, it should guarantee a sufficient vessel scaffolding. The present study proposes an optimization framework aiming at increasing the fatigue life reducing the maximum strut strain along the structure through a local modification of the strut profile.The adopted computational framework relies on nonlinear structural finite element analysis combined with a Multi Objective Genetic Algorithm, based on Kriging response surfaces...
July 10, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28705057/applicability-and-procedural-success-rate-of-bioresorbable-vascular-scaffolds-for-percutaneous-coronary-intervention-in-an-all-comer-cohort-of-383-consecutive-patients
#5
Christian Schlundt, Stephan Achenbach, Fabiola Felten, Jens Roether, Mohamed Marwan, Holger Nef, Josef Ludwig, Monique Tröbs
Objectives The purpose of this study was to determine applicability and procedural success of bioresorbable vascular scaffolds (BVS) for percutaneous coronary intervention (PCI) in an all-comer cohort. Background BVS use in bifurcations and severely calcified lesions is not recommended, and a relatively large crossing profile may cause limitations. It is has never been studied how widely BVS can be applied in all-comer cohorts. Methods In 383 consecutive patients (acute coronary syndrome: 124, stable coronary disease 259), a BVS (Absorb) was used as first-line device unless any of the following contraindications were present: bifurcation with side branch >2...
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28685314/conformability-in-everolimus-eluting-bioresorbable-scaffolds-compared-with-metal-platform-coronary-stents-in-long-lesions
#6
Jiang Ming Fam, Yuki Ishibashi, Cordula Felix, Bu Chun Zhang, Roberto Diletti, Nicolas van Mieghem, Evelyn Regar, Ron van Domburg, Yoshinobu Onuma, Robert-Jan van Geuns
The aim of this study was to determine if there are significant differences in curvature of the treated vessel after the deployment of a polymeric BRS or MPS in long lesions. The impact of long polymeric bioresorbable scaffolds (BRS) compared with metallic platform stents (MPS) on vessel curvature is unknown. This retrospective study compares 32 patients who received a single everolimus-eluting BRS with 32 patients treated with a single MPS of 28 mm. Quantitative coronary angiography (QCA) was used to evaluate curvature of the treatment and peri-treatment region before and after percutaneous coronary intervention (PCI)...
July 6, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28680011/bioresorbable-vascular-scaffolds%C3%A3-are-we-facing-a-time-of-crisis-or-one-of-breakthrough
#7
Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim
Current 2nd-generation drug-eluting stents (DES) have dramatically improved clinical outcomes after percutaneous coronary intervention for coronary artery disease. However, DES implantation has major long-term limitations related to the permanent presence of foreign material in the coronary artery. Bioresorbable vascular scaffolds (BVS) were designed to overcome this limitation of permanent metal-based DES. However, because of immature manufacturing technology, BVS have several drawbacks, such as the thicker strut, poor deliverability, poor radio-opacity, poor radial strength, and cumbersome procedure to meet the principle of PSP (Preparation, Sizing, and Post-dilatation)...
July 6, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28671552/mid-term-clinical-outcomes-with-everolimus-eluting-bioresorbable-scaffolds-versus-everolimus-eluting-metallic-stents-for-percutaneous-coronary-interventions-a-meta-analysis-of-randomized-trials
#8
Salvatore Cassese, Byrne A Robert, Peter Jüni, Joanna J Wykrzykowska, Serban Puricel, Gjin Ndrepepa, Heribert Schunkert, Massimiliano Fusaro, Stephane Cook, Takeshi Kimura, Jose P S Henriques, Patrick W Serruys, Stephan Windecker, Adnan Kastrati
AIMS: To compare the mid-term clinical outcomes of patients treated with everolimus-eluting bioresorbable scaffold (BVS) versus everolimus-eluting metallic stent (EES) for percutaneous coronary intervention. METHODS AND RESULTS: We performed a meta-analysis of aggregate data by searching Medline, EMBASE, Cochrane databases and proceedings of international meetings for randomized trials reporting the clinical outcomes beyond 1 year of patients treated with BVS versus EES...
July 4, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28667809/coronary-artery-aneurysm-after-bioresorbable-scaffold-implantation
#9
Rodrigo V Wainstein, Gustavo N Araujo, Felipe H Valle, Marco V Wainstein
The clinical course of coronary artery aneurysms after drug-eluting stent implantation is variable. Some aneurysms naturally resolve, but some can lead to complications such as stent thrombosis. In order to avoid such complications, it is important to reduce as much as possible the chance of exposing causal factors, and intravascular imaging may be needed in order to accurately assess the results of stent deployment and apposition. In the presented case, intravascular imaging was shown to be useful in accurately assessing the results of bioresorbable stent deployment and apposition...
July 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28667808/coronary-artery-aneurysm-after-bioresorbable-scaffold-implantation-in-a-woman-with-an-acute-coronary-syndrome
#10
Alberto F Cereda, Paolo A Canova, Jacopo A Oreglia, Francesco S Soriano
We herein report the case of an ST-elevation myocardial infarction due to bioresorbable vascular scaffold (BRS) failure. Optical coherence tomography (OCT) revealed the exact mechanism of late BRS stent thrombosis due to an acquired coronary aneurysm related to BRS. A drug eluting OCT-guided stenting over a failed BRS in the context of an acute coronary syndrome, with the simultaneous presence of a BRS thrombosis and coronary artery aneurysm, proved to be effective.
July 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28662808/arterial-remodeling-after-bioresorbable-scaffolds-and-metallic-stents
#11
Patrick W Serruys, Yuki Katagiri, Yohei Sotomi, Yaping Zeng, Bernard Chevalier, René J van der Schaaf, Andreas Baumbach, Pieter Smits, Nicolas M van Mieghem, Antonio Bartorelli, Paul Barragan, Anthony Gershlick, Ran Kornowski, Carlos Macaya, John Ormiston, Jonathan Hill, Irene M Lang, Mohaned Egred, Jean Fajadet, Maciej Lesiak, Stephan Windecker, Robert A Byrne, Lorenz Räber, Robert-Jan van Geuns, Gary S Mintz, Yoshinobu Onuma
BACKGROUND: Although previous observational studies have documented late luminal enlargement and expansive remodeling following implantation of a bioresorbable vascular scaffold (BVS), no comparison with metallic stents has been conducted in a randomized fashion. OBJECTIVES: This study sought to compare vessel remodeling patterns after either Absorb BVS or Xience metallic drug-eluting stent (DES) implantation (Abbott Vascular, Santa Clara, California) and determine the independent predictors of remodeling...
July 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28651349/an-autopsy-case-of-sudden-cardiac-death-due-to-in-scaffold-restenosis-and-late-scaffold-thrombosis-after-bioresorbable-vascular-scaffold-implantation-back-to-past-stent-era
#12
Kumiko Asakura, Hiroyuki Hao
No abstract text is available yet for this article.
June 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28646446/innovations-in-the-endovascular-management-of-critical-limb-ischemia-retrograde-tibiopedal-access-and-advanced-percutaneous-techniques
#13
REVIEW
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
PURPOSE OF REVIEW: Retrograde tibiopedal access and interventions have contributed to advance of endovascular techniques to treat critical limb ischemia (CLI) patients. This review encompasses the spectrum from advanced diagnostic imaging and technical therapeutic approaches for infrapopliteal occlusions, to a discussion of current standards and future directions. RECENT FINDINGS: Contemporary studies of infrapopliteal angioplasty show suboptimal short-term and 1-year clinical outcomes...
August 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28644215/treatment-of-coronary-stent-restenosis-with-drug-eluting-bioabsorbable-magnesium-scaffolds
#14
Fernando Alfonso, Javier Cuesta, Marcos García-Guimaraes, Teresa Bastante, Ramón Maruri, Fernando Rivero
No abstract text is available yet for this article.
June 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28643297/recommendations-for-the-use-of-bioresorbable-vascular-scaffolds-in-percutaneous-coronary-interventions-2017-revision
#15
B Everaert, J J Wykrzykowska, J Koolen, P van der Harst, P den Heijer, J P Henriques, R van der Schaaf, B de Smet, S H Hofma, R Diletti, A Weevers, J Hoorntje, P Smits, R J van Geuns
BACKGROUND: To eliminate some of the potential late limitations of permanent metallic stents, the bioresorbable coronary stents or 'bioresorbable vascular scaffolds' (BVS) have been developed. METHODS: We reviewed all currently available clinical data on BVS implantation. RESULTS: Since the 2015 position statement on the appropriateness of BVS in percutaneous coronary interventions, several large randomised trials have been presented. These have demonstrated that achieving adequate 1 and 2 year outcomes with these first-generation BVS is not straightforward...
July 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28639098/a-head-to-head-comparison-of-xinsorb-bioresorbable-sirolimus-eluting-scaffold-versus-metallic-sirolimus-eluting-stent-180-days-follow-up-in-a-porcine-model
#16
Li Shen, Yizhe Wu, Lei Ge, Yaojun Zhang, Qibing Wang, Juying Qian, Zhifen Qiu, Junbo Ge
We aimed to investigate the safety and efficacy of XINSORB bioresorbable sirolimus-eluting scaffold in porcine model. XINSORB scaffolds and metallic Firebird2™ stents were randomly implanted into minipigs' coronary arteries. Angiography, optical coherent tomography (OCT) and histopathological analyses were performed at post-procedure and 14-, 28-, 90-, 180-day follow-up. Thirty-two minipigs were enrolled. Eight XINSORB scaffolds and 8 Firebird2 stents were examined at each time point. Quantitative coronary angiography showed that in-scaffold late luminal loss (LLL) of XINSORB scaffold was 0...
June 21, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28626262/a-case-of-anterior-communicating-artery-aneurysm-successfully-treated-after-a-stent-migration-during-stent-assisted-endovascular-coil-embolization
#17
Tomotaka Ohshima, Andrey Belayev, Shunsaku Goto, Taiki Yamamoto, Kojiro Ishikawa, Yoko Kato
Stent migration is a complication associated with endovascular coil embolization of intracranial aneurysms. We report a case of anterior communicating artery (ACoA) aneurysm that was successfully treated after stent migration during endovascular coil embolization without retrieval of the stent. A 47-year-old man presented with sudden onset severe headache. Patient was noted to have subarachnoid hemorrhage from a ruptured ACoA aneurysm. Emergency endovascular coil embolization was performed. The second coil embolization was scheduled for the neck-remnant portion with a stent after 16 days from the initial operation...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28618851/crush-deformation-of-a-balloon-expandable-stent-implanted-in-an-infrainguinal-bypass-graft
#18
Nida Ahmed, Rym El-Khoury, Moustafa N Sabri, John V White, Chad E Jacobs, Lewis B Schwartz
A 59-year-old man with critical claudication underwent left femoro-anterior bypass grafting, which was uneventful. The graft was tunneled medially across the knee, then anterior to the tibia. His symptoms recurred 1 year later and he was found to have critical stenosis of the vein graft just proximal to the anterior tibial arterial anastomosis. This was treated with scaffolded balloon angioplasty and implantation of a coronary, zotarolimus-eluting balloon-expandable stent, which was also uneventful. However, his claudication again recurred 1 year later...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28617560/influence-of-vegf-bmp-2-on-the-proliferation-and-osteogenetic-differentiation-of-rat-bone-mesenchymal-stem-cells-on-plga-gelatin-composite-scaffold
#19
G An, W-B Zhang, D-K Ma, B Lu, G-J Wei, Y Guang, C-H Ru, Y-S Wang
OBJECTIVE: To investigate the influence of VEGF/BMP-2 on the proliferation and osteogenic differentiation of rat bone mesenchymal stem cells BMSCs) on PLGA/gelatin composite scaffold. MATERIALS AND METHODS: Randomly-oriented nanofibers with different ratios of Poly Lactic-co-Glycolic Acid (PLGA)/gelatin were produced through electrospinning. The mixture of nanofibers and BMSCs was pipetted onto the surface of the scaffolds, and BMSCs/PLGA/gelatin composite was obtained...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28612414/the-invisible-scaffold%C3%A2-with-invisible-benefits
#20
EDITORIAL
Sandeep K Krishnan, Larry S Dean
Authors suggest the use of an investigator-owned and directed, prospective, non-randomized, single-arm multicenter registry at 23 Italian hospitals to follow 500 STEMI patients who receive BVS. Follow-up of patients is out to 5 years to determine how a BVS which has been deployed according to the IFU performs in these ACS patients. There is no comparator arm. Mandate that patients included in this registry follow a strict BVS implantation protocol which is felt to mitigate the not insignificant stent thrombosis rates noted with BVS to date...
June 1, 2017: Catheterization and Cardiovascular Interventions
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