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Biodegradable stents

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https://www.readbyqxmd.com/read/28919738/surface-modification-of-endovascular-stents-with-rosuvastatin-and-heparin-loaded-biodegradable-nanofibers-by-electrospinning
#1
Milka Janjic, Foteini Pappa, Varvara Karagkiozaki, Christakis Gitas, Kiriakos Ktenidis, Stergios Logothetidis
This study describes the development of drug-loaded nanofibrous scaffolds as a nanocoating for endovascular stents for the local and sustained delivery of rosuvastatin (Ros) and heparin (Hep) to injured artery walls after endovascular procedures via the electrospinning process. PURPOSE: The proposed hybrid covered stents can promote re-endothelialization; improve endothelial function; reduce inflammatory reaction; inhibit neointimal hyperplasia of the injured artery wall, due to well-known pleiotropic actions of Ros; and prevent adverse events such as in-stent restenosis (ISR) and stent thrombosis (ST), through the antithrombotic action of Hep...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28918561/marine-polysaccharides-therapeutic-efficacy-and-biomedical-applications
#2
REVIEW
Young-Eun Lee, Hyeongmin Kim, Changwon Seo, Taejun Park, Kyung Bin Lee, Seung-Yup Yoo, Seong-Chul Hong, Jeong Tae Kim, Jaehwi Lee
The ocean contains numerous marine organisms, including algae, animals, and plants, from which diverse marine polysaccharides with useful physicochemical and biological properties can be extracted. In particular, fucoidan, carrageenan, alginate, and chitosan have been extensively investigated in pharmaceutical and biomedical fields owing to their desirable characteristics, such as biocompatibility, biodegradability, and bioactivity. Various therapeutic efficacies of marine polysaccharides have been elucidated, including the inhibition of cancer, inflammation, and viral infection...
September 16, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28917130/bending-behaviors-of-fully-covered-biodegradable-polydioxanone-biliary-stent-for-human-body-by-finite-element-method
#3
Yanhui Liu, Guoqing Zhu, Huazhe Yang, Conger Wang, Peihua Zhang, Guangting Han
This paper presents a study of the bending flexibility of fully covered biodegradable polydioxanone biliary stents (FCBPBs) developed for human body. To investigate the relationship between the bending load and structure parameter (monofilament diameter and braid-pin number), biodegradable polydioxanone biliary stents derived from braiding method were covered with membrane prepared via electrospinning method, and nine FCBPBSs were then obtained for bending test to evaluate the bending flexibility. In addition, by the finite element method, nine numerical models based on actual biliary stent were established and the bending load was calculated through the finite element method...
August 24, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28889769/orsiro-cobalt-chromium-sirolimus-eluting-stent-present-and-future-perspectives
#4
Juan F Iglesias, Marco Roffi, Sophie Degrauwe, Gioel Gabrio Secco, Adel Aminian, Stephan Windecker, Thomas Pilgrim
New-generation drug-eluting stents (DES) represent the current standard of care in patients undergoing percutaneous coronary intervention (PCI). Biodegr adable polymer DES (BP-DES) were recently developed to overcome current limitations of newer-generation durable polymer DES (DP-DES) attributed to sustained inflammatory responses induced by permanent polymers. The Orsiro DES (Biotronik AG, Bülach, Switzerland) is a novel thin-strut cobalt-chromium sirolimus-eluting stent with biodegradable polymer that features some of the latest developments in DES technology...
September 11, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28888019/in-vivo-characterization-of-a-3d-hybrid-scaffold-based-on-pcl-decellularized-aorta-for-tracheal-tissue-engineering
#5
Fariba Ghorbani, Lida Moradi, Mohammad Behgam Shadmehr, Shahin Bonakdar, Atosa Droodinia, Farzaneh Safshekan
INTRODUCTION: As common treatments for long tracheal stenosis are associated with several limitations, tracheal tissue engineering is considered as an alternative treatment. AIM OF STUDY: This study aimed at preparing a hybrid scaffold, based on biologic and synthetic materials for tracheal tissue engineering. MATERIALS AND METHODS: Three electrospun polycaprolactone (PCL) scaffolds, namely E1 (pure PCL), E2 (collagen-coated PCL) and E3 (PCL blended with collagen) were prepared...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28877531/towards-individualized-tracheobronchial-stents-technical-practical-and-legal-considerations
#6
Lutz Freitag, Martin Gördes, Paul Zarogoulidis, Kaid Darwiche, Daniel Franzen, Faustina Funke, Wolfgang Hohenforst-Schmidt, Hervé Dutau
Stent placement has been established as a standard procedure for treating airway obstructions. Other indications are localized malacias and fistulas. Though many different stents with various diameters and lengths are available, the shapes are hardly ever ideal because of the distorted anatomy in patients with diseased airways. There are technical and legal limitations for customizing purchased airway stents. Individually tailored stents would be preferable. New techniques of additive manufacturing such as 3D printing make it possible to produce optimized stents for a particular patient...
September 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28874301/polymer-free-amphilimus-eluting-stent-versus-biodegradable-polymer-biolimus-eluting-stent-in-patients-with-and-without-diabetes-mellitus
#7
Cosmo Godino, Carlo Andrea Pivato, Mauro Chiarito, Michael Donahue, Luca Testa, Riccardo Colantonio, Alberto Cappelletti, Diego Milazzo, Rosario Parisi, Annamaria Nicolino, Shahram Moshiri, Gianfranco Aprigliano, Altin Palloshi, Dennis Zavalloni Parenti, David Rutigliano, Nicola Locuratolo, Francesco Melillo, Andrea Scotti, Luca Arrigoni, Matteo Montorfano, Rossella Fattori, Patrizia Presbitero, Gennaro Sardella, Francesco Bedogni, Alberto Margonato, Carlo Briguori, Antonio Colombo
OBJECTIVES: This study sought to compare clinical outcome of polymer-free amphilimus-eluting stent (PF-AES) versus biodegradable-polymer biolimus-eluting stent (BD-BES) in "all-comer" diabetes mellitus (DM) and non-DM patients who underwent percutaneous coronary intervention. BACKGROUND: The PF-AES has shown promising preliminary results in patients with DM. METHODS: Data from 2 multicentre-national registries (the ASTUTE and the INSPIRE-1) were used to analyse 1776 patients stratified in non-DM and DM...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28870882/2-year-outcome-after-biodegradable-polymer-sirolimus-and-biolimus-eluting-coronary-stents-from-the-randomized-sort-out-vii-trial
#8
Lisette Okkels Jensen, Michael Maeng, Bent Raungaard, Knud Nørregaard Hansen, Johnny Kahlert, Svend Eggert Jensen, Henrik Steen Hansen, Jens Flensted Lassen, Hans Erik Bøtker, Evald Høj Christiansen
AIMS: The SORT OUT VII trial compared the thin-strut cobalt-chromium sirolimus-eluting Orsiro stent with a slow polymer degradation and the thicker-strut stainless steel biolimus-eluting Nobori stent with a moderate-term polymer degradation in an all-comer patient population. METHODS AND RESULTS: The 2-year pre-specified endpoint target lesion failure did not differ significantly between the sirolimus-eluting stent: 6.7% and the biolimus-eluting stent: 7.0% (rate ratio (RR) 0...
September 5, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28866142/in-vitro-and-in-vivo-degradation-of-rapamycin-eluting-mg-nd-zn-zr-alloy-stents-in-porcine-coronary-arteries
#9
Yongjuan Shi, Lei Zhang, Jiahui Chen, Jian Zhang, Feng Yuan, Li Shen, Chenxin Chen, Jia Pei, Zhonghua Li, Jinyun Tan, Guangyin Yuan
In this work, rapamycin-eluting poly (d, l-lactic acid) coating (PDLLA/RAPA) was prepared on biodegradable Mg-Nd-Zn-Zr alloy (JDBM) for both in vitro and in vivo investigation of the degradation behaviors of the magnesium alloy stent platform. Electrochemical tests and hydrogen evolution test demonstrated significant in vitro protection of the polymeric coating against magnesium degradation both in short and long term. The 3-month in vivo study on the RAPA-eluting JDBM stent implanted into porcine coronary arteries confirmed its favorable safety, and in the meanwhile revealed similar neointima proliferation compared to the second generation DES Firebird 2 with no occurrence of adverse complications...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28846543/final-five-year-outcomes-after-implantation-of-biodegradable-polymer-coated-biolimus-eluting-stents-versus-durable-polymer-coated-sirolimus-eluting-stents
#10
Lars Jakobsen, Evald H Christiansen, Michael Maeng, Knud N Hansen, Steen D Kristensen, Hans E Bøtker, Christian J Terkelsen, Svend E Jensen, Bent Raungaard, Morten Madsen, Jens F Lassen, Lisette O Jensen
AIMS: To report long-term safety and efficacy of the biodegradable polymer-coated biolimus-eluting Nobori stent compared to the durable polymer-coated sirolimus-eluting Cypher stent. METHODS AND RESULTS: SORT OUT V randomized 2,468 patients 1:1 to the Nobori (n=1,229) versus the Cypher stent (n=1,239). Clinically driven event detection based on Danish registries was used. The primary endpoint was a composite of safety (cardiac death, myocardial infarction, definite stent thrombosis) and efficacy (target vessel revascularization)...
August 29, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28843580/a-biodegradable-noncovered-self-expandable-stent-to-treat-pancreatic-duct-strictures-in-chronic-pancreatitis-a-proof-of-principle
#11
Djuna L Cahen, Schalk W van der Merwe, Wim Laleman, Jan-Werner Poley, Marco J Bruno
BACKGROUND AND AIMS: In chronic pancreatitis (CP), fibrotic pancreatic duct (PD) strictures pose a therapeutic challenge, as endoscopic dilatation requires multiple procedures, with suboptimal results. Biodegradable self-expandable stents (BD-SESs) may serve as an alternative in this setting. METHODS: CP patients were eligible for this proof-of-principle study, if at least 6 months of endoscopic dilatation with plastic stents had failed to resolve their PD stricture...
August 23, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28838256/comparative-study-of-different-polymeric-coatings-for-the-next-generation-magnesium-based-biodegradable-stents
#12
Gholamreza Ahmadi Lakalayeh, Mostafa Rahvar, Esmaeil Haririan, Roya Karimi, Hossein Ghanbari
Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility...
August 24, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28835063/-process-of-the-degradation-in-vivo-and-biosafety-of-biodegradable-magnesium-alloy-stent
#13
D Yang, Y G Li, L Wang, J Y Lü, D Yu, S J Xin
Objective: To observe the degradation process of biodegradable magnesium alloy stent (BMAS) in vivo in order to evaluate its degradation time and biological safety. Methods: Twenty-four male New Zealand white rabbits were divided into two groups: group A (n=12) and group B (n=12). The BMAS (a total of 12) was implanted in the infrarenal aorta of each rabbit in group A, while group B was the control group, without treatment. Color Doppler ultrasound was used at the 1, 2, 3, 4 months postoperatively to observe the degradation process of stents in group A...
August 22, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28826352/pcl-pdms-pcl-copolymer-based-microspheres-mediate-cardiovascular-differentiation-from-embryonic-stem-cells
#14
Liqing Song, Mohammad Faisal Ahmed, Yan Li, Julie Bejoy, Changchun Zeng, Yan Li
Poly-ϵ-caprolactone (PCL) based microspheres have received much attention as drug or growth factor delivery carriers and tissue engineering scaffolds due to their biocompatibility, biodegradability, and tunable biophysical properties. In addition, PCL and polydimethylsiloxane (PDMS) can be fabricated into thermo-responsive shape memory polymers for various biomedical applications (e.g., smart sutures and vascular stents). However, the influence of biophysical properties of PCL-PDMS based microspheres on stem cell lineage commitment has not been well understood...
August 21, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28819961/-bioresorbable-scaffolds-in-the-treatment-of-coronary-artery-disease-expert-consensus-statement-of-the-association-of-cardiovascular-interventions-of-the-polish-cardiac-society-acvi-pcs
#15
Krzysztof Reczuch, Krzysztof Milewski, Wojciech Wąsek, Łukasz Rzeszutko, Wojciech Wojakowski, Michał Hawranek, Adrian Włodarczak, Tomasz Pawłowski, Janusz Kochman, Sławomir Dobrzycki, Marek Grygier, Andrzej Ochała, Jarosław Wójcik, Maciej Lesiak, Dariusz Dudek, Jacek Legutko
Bioresorbable scaffold coated with antimitotic drug is the latest development in the coronary stents technology. The concept of temporary scaffolding and natural vessel healing after angioplasty is a very attractive alternative to conventional metal stents. The results of the first observational studies have confirmed their ultimate biodegradation. Newest results of randomised trials and registries in broader clinical and anatomical indications also revealed the limitations of the first generation of scaffolds...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28800599/extracting-information-from-free-text-electronic-patient-records-to-identify-practice-based-evidence-of-the-performance-of-coronary-stents
#16
Yoon Seob Kim, Dukyong Yoon, JungHyun Byun, Hojun Park, Ahram Lee, Il Hyun Kim, Sukhoon Lee, Hong-Seok Lim, Rae Woong Park
BACKGROUND AND OBJECTIVE: Percutaneous coronary intervention (PCI) using drug-eluting stents (DES) is an indispensable treatment for coronary artery disease. However, to evaluate the performance of various types of stents for PCI, numerous resources are required. We extracted clinical information from free-text records and, using practice-based evidence, compared the efficacy of various DES. MATERIALS AND METHODS: We developed a text mining tool based on regular expression and applied it to PCI reports stored in the electronic health records (EHRs) of Ajou University Hospital from 2010-2014...
2017: PloS One
https://www.readbyqxmd.com/read/28797113/clinical-outcomes-of-biodegradable-polymer-biolimus-eluting-biomatrix-stents-versus-durable-polymer-everolimus-eluting-xience-stents
#17
Da Hyon Lee, Taek Kyu Park, Young Bin Song, Woo Jung Chun, Rak Kyeong Choi, Jin-Ok Jeong, Eul Soon Im, Sang Wook Kim, Joo Myung Lee, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon
There are limited data about clinical outcomes of biodegradable polymer biolimus-eluting BioMatrix stents (BP-BES) and durable polymer everolimus-eluting Xience stents (DP-EES) in real world practice. We sought to compare the clinical outcomes of BP-BES and DP-EES in real world cohorts of patients undergoing percutaneous coronary intervention. A prospective multicenter registry enrolled 999 patients treated with BP-BES and 1,000 patients treated with DP-EES. The primary outcome was target lesion failure, defined as a composite of cardiac death, target vessel-related myocardial infarction, or target lesion revascularization...
2017: PloS One
https://www.readbyqxmd.com/read/28797069/biodegradability-and-platelets-adhesion-assessment-of-magnesium-based-alloys-using-a-microfluidic-system
#18
Lumei Liu, Youngmi Koo, Boyce Collins, Zhigang Xu, Jagannathan Sankar, Yeoheung Yun
Magnesium (Mg)-based stents are extensively explored to alleviate atherosclerosis due to their biodegradability and relative hemocompatibility. To ensure the quality, safety and cost-efficacy of bioresorbable scaffolds and full utilization of the material tunability afforded by alloying, it is critical to access degradability and thrombosis potential of Mg-based alloys using improved in vitro models that mimic as closely as possible the in vivo microenvironment. In this study, we investigated biodegradation and initial thrombogenic behavior of Mg-based alloys at the interface between Mg alloys' surface and simulated physiological environment using a microfluidic system...
2017: PloS One
https://www.readbyqxmd.com/read/28796171/research-on-a-nonwoven-fabric-made-from-multi-block-biodegradable-copolymer-based-on-l-lactide-glycolide-and-trimethylene-carbonate-with-shape-memory
#19
Joanna Walczak, Michał Chrzanowski, Izabella Krucińska
The presented paper concerns scientific research on processing a poly(lactide-co-glycolide-co-trimethylene carbonate) copolymer (PLLAGLTMC) with thermally induced shape memory and a transition temperature around human body temperature. The material in the literature called terpolymer was used to produce smart, nonwoven fabric with the melt blowing technique. Bioresorbable and biocompatible terpolymers with shape memory have been investigated for its medical applications, such as cardiovascular stents. There are several research studies on shape memory in polymers, but this phenomenon has not been widely studied in textile products made from shape memory polymers (SMPs)...
August 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28780463/arginine-leucine-based-poly-ester-urea-urethane-coating-for-mg-zn-y-nd-alloy-in-cardiovascular-stent-applications
#20
Jing Liu, Pei Wang, Chih-Chang Chu, Tingfei Xi
Selected from the family of self-designed biodegradable amino acid-based poly (ester urea urethane) (AA-PEUU) pseudo-protein biomaterials, arginine-leucine based poly (ester urea urethane)s (Arg-Leu-PEUUs) were used as protective and bio-functional coatings for bio-absorbable magnesium alloy MgZnYNd in cardiovascular stent applications. Comparing with poly (glycolide-co-lactide) (PLGA) coating, the Arg-Leu-PEUU coating had stronger bonding strength with the substrate; in vitro electrochemical and long-term immersion results verified a significantly better corrosion resistance...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
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