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Biodegradable stents

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https://www.readbyqxmd.com/read/29770422/biodegradable-toughened-nanohybrid-shape-memory-polymer-for-smart-biomedical-applications
#1
Arpan Biswas, Akhand Pratap Singh, Dipak Rana, Vinod K Aswal, Pralay Maiti
A polyurethane nanohybrid has been prepared through the in situ polymerization of an aliphatic diisocyanate, ester polyol and a chain extender in the presence of two-dimensional platelets. Polymerization within the platelet galleries helps to intercalate, generate diverse nanostructure and improve the nano to macro scale self-assembly, which leads to a significant enhancement in the toughness and thermal stability of the nanohybrid in comparison to pure polyurethane. The extensive interactions, the reason for property enhancement, between nanoplatelets and polymer chains are revealed through spectroscopic measurements and thermal studies...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29760284/unprotected-left-main-coronary-artery-disease-outcomes-of-treatment-with-second-generation-drug-eluting-stents-insight-from-the-fails-2-study
#2
Umberto Barbero, Rahim Kanji, Enrico Cerrato, Roberto Di Summa, Federico Conrotto, Hiroyoshi Kawamoto, Giuseppe Biondi-Zoccai, Sebastiano Gili, Fabrizio Ugo, Mario Iannaccone, Marco Gagliardi, Michele De Benedictis, Baldassarre Doronzo, Ferdinando Varbella, Maurizio D'Amico, Claudio Moretti, Antonio Colombo, Javier Escaned, Fabrizio D'Ascenzo
OBJECTIVE: To evaluate the outcome of patients undergoing PCI for unprotected left main coronary artery (ULMCA) disease with different drug-eluting stent (DES) types. BACKGROUND: Published literature suggests that second-generation DES options have differing vascular responses and outcomes, but there is a paucity of data in real-life patients in the LM setting. METHODS: This is a retrospective, multicenter study, including patients treated with a second-generation DES for ULMCA disease between 2007 and 2015...
May 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29745539/-endothelial-injury-and-its-repair-strategies-after-intravascular-stents-implantation
#3
REVIEW
Yadong Xi, Yuhua Huang, Ruolin Du, Yazhou Wang, Guixue Wang, Tieying Yin
Coronary atherosclerotic heart disease is a serious threat to human life and health. In recent years, the main treatment for it is to implant the intravascular stent into the lesion to support blood vessels and reconstruct blood supply. However, a large number of experimental results showed that mechanical injury and anti-proliferative drugs caused great damage after stent implantation, and increased in-stent restenosis and late thrombosis risk. Thus, maintaining the integrity and normal function of the endothelium can significantly reduce the rate of thrombosis and restenosis...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29735265/a-quantitative-study-on-magnesium-alloy-stent-biodegradation
#4
Yuanming Gao, Lizhen Wang, Xuenan Gu, Zhaowei Chu, Meng Guo, Yubo Fan
Insufficient scaffolding time in the process of rapid corrosion is the main problem of magnesium alloy stent (MAS). Finite element method had been used to investigate corrosion of MAS. However, related researches mostly described all elements suffered corrosion in view of one-dimensional corrosion. Multi-dimensional corrosions significantly influence mechanical integrity of MAS structures such as edges and corners. In this study, the effects of multi-dimensional corrosion were studied using experiment quantitatively, then a phenomenological corrosion model was developed to consider these effects...
April 25, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29724350/efficacy-over-time-with-drug-eluting-stents-in-saphenous-vein-graft-lesions
#5
Roisin Colleran, Sebastian Kufner, Julinda Mehilli, Christian Rosenbeiger, Stefanie Schüpke, Petra Hoppmann, Michael Joner, Nader Mankerious, Massimiliano Fusaro, Salvatore Cassese, Mohamed Abdel-Wahab, Franz-Josef Neumann, Gert Richardt, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert A Byrne
BACKGROUND: In the ISAR-CABG (Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts?) trial, clinical outcomes at 1 year in patients undergoing treatment of saphenous vein graft lesions were superior with drug-eluting stents (DES) versus bare-metal stents. OBJECTIVES: The authors compared outcomes between treatment groups at 5 years. METHODS: Patients were randomized (1:1:1:3) to receive DES (either permanent-polymer paclitaxel-eluting stents, permanent-polymer sirolimus-eluting stents, or biodegradable-polymer sirolimus-eluting stents) or bare-metal stents...
May 8, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29704312/self-expandable-tubular-collagen-implants
#6
Luuk R M Versteegden, Marja Ter Meer, Roger M L M Lomme, J Adam van der Vliet, Leo J Schultze Kool, Toin H van Kuppevelt, Willeke F Daamen
Collagen has been extensively used as a biomaterial, yet for tubular organ repair synthetic polymers or metals (e.g. stents) are typically used. In this study we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time and possibilities to add bioactive components to the scaffold, such as anti-coagulants...
April 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29687605/shape-memory-properties-and-enzymatic-degradability-of-poly-%C3%AE%C2%B5-caprolactone-based-polyurethane-urea-containing-phenylalanine-derived-chain-extender
#7
Rong Wang, Fanjun Zhang, Weiwei Lin, Wenkai Liu, Jiehua Li, Feng Luo, Yaning Wang, Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29658669/-segmented-biodegradable-esophageal-stents-in-a-porcine-model-preclinical-evaluation-of-degradation-complications-and-tissue-reactions
#8
Yang Cao, Yadong Feng, Chunhua Jiao, Ruihua Shi
<b>Objective:</b> To evaluate the feasibility of two types of segmented biodegradable esophageal stents in treatment of refractory benign esophagus strictures. <b>Methods:</b> Uncovered biodegradable segmented stent and fully-covered biodegradable segmented stent were implanted into the porcine esophagus (6 for each). Data on biodegradation, complications, and tissue reactions were compared between two groups. <b>Results:</b> All animals kept good general conditions; no death, decreased food intake, weight loss and malnutrition were observed...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29651802/three-months-optical-coherence-tomography-analysis-of-a-biodegradable-polymer-sirolimus-eluting-stent
#9
Еvgeny Kretov, Ivan Naryshkin, Vitaly Baystrukov, Igor Grazhdankin, Aleksei Prokhorikhin, Dmitry Zubarev, Alexey Biryukov, Vladimir Verin, Andrey Boykov, Dastan Malaev, Evgeny Pokushalov, Alexander Romanov, Martin W Bergmann
OBJECTIVE: We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus-eluting stent with biodegradable polymer. BACKGROUND: New generations of drug-eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers. METHODS: In this prospective, open-label study, 34 patients received an Orsiro® sirolimus-eluting stent with biodegradable polymer...
April 12, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29629708/dipyridamole-loaded-biodegradable-pla-nanoplatforms-as-coatings-for-cardiovascular-stents
#10
Veroniki Bakola, Varvara Karagkiozaki, Aikatherini-Rafailia Tsiapla, Foteini Pappa, Ioannis Moutsios, Eleni Pavlidou, Stergious Logothetidis
Cardiovascular Stents are commonly used for the treatment of Cardiovascular Diseases (CVDs) that in developed societies, are the most frequent causes of mortality and morbidity. Recent years, thorough research and development of Drug Eluting Stents (DES) has been done, with emphasis on coronary stenting to avoid the most common complication, the in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug Delivery Nanoplatforms consisting of biodegradable polymers can be fabricated via Electrospinning Deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds able of sustainable and controllable drug release...
April 9, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29622449/one-year-clinical-outcome-of-biodegradable-polymer-sirolimus-eluting-stent-in-all-comers-population-insight-from-the-ulisse-registry-ultimaster-italian-multicenter-all-comers-stent-registry
#11
Cosmo Godino, Alessandro Beneduce, Giuseppe Ferrante, Alfonso Ielasi, Andrea Carlo Pivato, Mauro Chiarito, Alberto Cappelletti, Giulia Perfetti, Valeria Magni, Eugenio Prati, Stefania Falcone, Adele Pierri, Stefano De Martini, Matteo Montorfano, Rosario Parisi, David Rutigliano, Nicola Locuratolo, Angelo Anzuini, Maurizio Tespilli, Alberto Margonato, Alberto Benassi, Carlo Briguori, Franco Fabbiocchi, Bernhard Reimers, Antonio Bartorelli, Antonio Colombo
BACKGROUND: This study was designed to confirm in a large population of unselected patients the promising results of Ultimaster® biodegradable polymer sirolimus-eluting stent (BP-SES) already shown in previous trial. METHODS: ULISSE is an observational, multicenter, national registry evaluating all patients undergoing PCI with the Ultimaster® BP-SES. Incidence of 1-year TLF (cardiac death or target vessel MI or clinically indicated TLR) was the primary endpoint...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619983/acute-thrombogenicity-of-fluoropolymer-coated-versus-biodegradable-and-polymer-free-stents
#12
Sho Torii, Qi Cheng, Hiroyoshi Mori, Michael J Lipinski, Eduardo Acampado, Laura E L Perkins, Syed F Hossainy, Stephen D Pacetti, Frank D Kolodgie, Renu Virmani, Aloke V Finn
AIMS: Durable-fluoropolymer coated everolimus-eluting stents (FP-EES) have shown lower rates of stent thrombosis (ST) versus bare-metal stents (BMS) and 1st-generation bioabsorbable-polymer (BP) DES. However, the specific role of the FP in thromboresistance has not been explored. METHODS AND RESULTS: A total of 57 stents were assessed in 3 separate ex-vivo swine arterio-venous shunt-model experiments [1st-shunt-experiment, custom-made fluoropolymer-coated BMS (FP-only) vs...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29607135/ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-being-wary-or-going-with-the-flow
#13
EDITORIAL
Salvatore Cassese, Anna Lena Lahmann, Michael Joner
No abstract text is available yet for this article.
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29606869/propylthiouracil-coated-biodegradable-polymer-inhibited-neointimal-formation-and-enhanced-re-endothelialization-after-vascular-injury
#14
Shang-Hung Chang, Cheng-Hung Lee, Yung-Hsin Yeh, Shih-Jung Liu, Chao-Jan Wang, Ming-Yi Hsu, Wei-Jan Chen
Background: The drug-eluting stent is a standard approach for the treatment of coronary artery disease. Propylthiouracil (PTU), an antithyroid drug, has been proven to suppress neointimal formation after balloon injury. Materials and methods: This study used a biodegradable polymer coating with PTU to test its effects on platelet function, re-endothelialization, and neointimal formation after vascular injury. Electrospinning was used to fabricate hybrid stents and generate PTU-loaded nanofibers...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29589672/the-synergy-stent-in-high-bleeding-risk-patients-why-design-matters
#15
Mauro Chiarito, Davide Cao, Francesco Cannata, Cristina Panico, Bernhard Reimers, Giulio G Stefanini
Antithrombotic management after percutaneous coronary intervention is based on dual antiplatelet therapy (DAPT), that has unequivocally shown to reduce the risk of recurrent ischemic events at cost of an important risk of bleeding. In order to balance ischemic and bleeding risks, DAPT duration should be based on patients and lesions features as well as stent type. Based on these considerations, patients at high bleeding risk (HBR) undergoing PCI represent a challenging subgroup. The Synergy stent (Boston Scientific, Marlborough, MA, USA) is a new-generation everolimus-eluting stent with a biodegradable polymer coating, presenting several features that have the potential to reduce acute and long-term thrombogenicity and the subsequent need for DAPT...
March 28, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#16
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29573134/magnetoelastic-galfenol-as-a-stent-material-for-wirelessly-controlled-degradation-rates
#17
Andrew DeRouin, Roger Guillory, Weilue He, Megan Frost, Jeremy Goldman, Keat Ghee Ong
The gold standard of care for coronary artery disease, a leading cause of death for in the world, is balloon angioplasty in conjunction with stent deployment. However, implantation injuries and long-term presence of foreign material often promotes significant luminal tissue growth, leading to a narrowing of the artery and severely restricted blood flow. A promising method to mitigate this process is the use of biodegradable metallic stents, but thus far they have either degraded too slowly (iron) or disappeared prematurely (magnesium)...
March 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29568667/effect-of-nonionic-surfactants-in-release-media-on-accelerated-in-vitro-release-profile-of-sirolimus-eluting-stents-with-biodegradable-polymeric-coating
#18
Ami Raval, Pratap Bahadur, Ankur Raval
It is a well-known fact that sirolimus (SRL) undergoes degradation process via hydrolysis in aqueous media, leading to incorrect assessment of drug amount and thus release characteristics of formulations. The main objective of the present study was to evaluate the effect of nonionic surfactants in media on in-vitro release profiles for sirolimus eluting stents (SES) coated with biodegradable polymeric matrix. Phosphate buffer and acetate buffer incorporating nonionic surfactants with varying concentrations were examined for adequate solubility and stability (by RP-HPLC)...
February 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29544956/randomised-comparison-of-vascular-response-to-biodegradable-polymer-sirolimus-eluting-and-permanent-polymer-everolimus-eluting-stents-an-optical-coherence-tomography-study
#19
Tobias Koppara, Tomohisa Tada, Erion Xhepa, Sebastian Kufner, Robert A Byrne, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati, Michael Joner
BACKGROUND: Drug-eluting stents with biodegradable polymer coatings have shown promising outcomes in randomised studies. METHODS: We compared neointimal healing patterns including strut coverage and assessed neointimal maturity using a novel algorithm in coronary lesions treated with sirolimus-eluting stents with biodegradable polymer coating (BP-SES) or everolimus eluting stents with permanent polymer coating (PP-EES) using optical coherence tomography after 6months...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29538391/in-vitro-study-of-the-inflammatory-cells-response-to-biodegradable-mg-based-alloy-extract
#20
Liang Jin, Jing Wu, Guangyin Yuan, Tongxin Chen
Biodegradable Mg-based alloys have shown great potential as bone fixation devices or vascular stents. As implant biomaterials, the foreign body reaction (FBR) is an important issue to be studied, where the inflammatory cells play a key role. Here, we used two inflammatory cell lines i.e. THP-1 cells and THP-1 macrophages, to evaluate the effect of Mg-Nd-Zn-Zr alloy (denoted as JDBM) extracts on cell viability, death modes, cell cycle, phagocytosis, differentiation, migration and inflammatory response. The results showed that high-concentration extract induced necrosis and complete damage of cell function...
2018: PloS One
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