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Biodegradable stents

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https://www.readbyqxmd.com/read/28068065/sustained-nitric-oxide-release-from-a-tertiary-s-nitrosothiol-based-polyphosphazene-coating
#1
Alec Lutzke, Jesus B Tapia, Megan J Neufeld, Melissa M Reynolds
Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing properties. NO-forming biodegradable polymers have been utilized in the development of antithrombotic or antibacterial materials for biointerfacial applications, including tissue engineering and the fabrication of erodible coatings for medical devices such as stents. Use of such NO-forming polymers has frequently been constrained by short-term release or limited NO storage capacity and has led to the pursuit of new materials with improved NO release function...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28058211/organ-transplantation-and-drug-eluting-stents-perioperative-challenges
#2
REVIEW
Aparna Dalal
Patients listed for organ transplant frequently have severe coronary artery disease (CAD), which may be treated with drug eluting stents (DES). Everolimus and zotarolimus eluting stents are commonly used. Newer generation biolimus and novolimus eluting biodegradable stents are becoming increasingly popular. Patients undergoing transplant surgery soon after the placement of DES are at increased risk of stent thrombosis (ST) in the perioperative period. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor such as clopidogrel, prasugrel and ticagrelor is instated post stenting to decrease the incident of ST...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28017123/current-state-of-bioabsorbable-polymer-coated-drug-eluting-stents
#3
Akinapelli Absdhilash, Jack P Chen, Kristine Roy, Joseph Donnelly, Keith Dawkins, Barbara Huibregtse, Dongming Hou
Drug-eluting stents (DES) have been shown to significantly reduce clinical and angiographic restenosis compared to bare metal stents (BMS). The polymer coatings on DES elute antiproliferative drugs to inhibit intimal proliferation and prevent restenosis after stent implantation. Permanent polymers which do not degrade in vivo may increase the likelihood of stent-related delayed arterial healing or polymer hypersensitivity. In turn, these limitations may contribute to an increased risk of late clinical events...
December 22, 2016: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28013101/ex-vivo-blood-vessel-bioreactor-for-analysis-of-the-biodegradation-of-magnesium-stent-models-with-and-without-vessel-wall-integration
#4
Juan Wang, Lumei Liu, Yifan Wu, Manfred F Maitz, Zhihong Wang, Youngmi Koo, Ansha Zhao, Jagannathan Sankar, Deling Kong, Nan Huang, Yeoheung Yun
: Current in vitro models fail in predicting the degradation rate and mode of magnesium (Mg) stents in vivo. To overcome this, the microenvironment of the stent is simulated here in an ex vivo bioreactor with porcine aorta and circulating medium, and compared with standard static in vitro immersion and with in vivo rat aorta models. In ex vivo and in vivo conditions, pure Mg wires were exposed to the aortic lumen and inserted into the aortic wall to mimic early- and long-term implantation, respectively...
December 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27999810/development-of-a-new-hybrid-biodegradable-drug-eluting-stent-for-the-treatment-of-peripheral-artery-disease
#5
Jung-Hee Lee, Soon-Joong Kim, Se-Il Park, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50 : 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30 : 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27992118/tolerance-and-pharmacokinetics-of-a-ciprofloxacin-coated-sinus-stent-in-a-preclinical-model
#6
Do-Yeon Cho, Daniel Skinner, Calvin Mackey, Kyle Hoffman, Dong Jin Lim, Ho-Wook Jun, Dong Keun Han, Bradford A Woodworth
BACKGROUND: Chronic rhinosinusitis (CRS) is often associated with persistent bacterial infection despite the use of systemic antibiotics. Topically administered antibiotics are an alternative strategy, but require effective local concentrations, prolonged mucosal contact time, minor systemic absorption, and minimal depletion. The objectives of the current study were to analyze the in vitro release rate and in vivo drug delivery tolerance and pharmacokinetics of a ciprofloxacin-coated sinus stent (CSS)...
December 19, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27989051/pga-polyglycolic-acid-p4hb-poly-4-hydroxybutyrate-based-bioengineered-valves-in-the-rat-aortic-circulation
#7
Agnieszka A Książek, Katharyn J Mitchell, Nikola Cesarovic, Colin C Schwarzwald, Simon P Hoerstrup, Benedikt Weber
BACKGROUND: Bioengineered living autologous valves with remodeling and growth capacity represent a promising concept for future cardiac and venous valve repair. A meticulous understanding of the mechanisms involved in recellularization and remodeling is essential for the safe and efficient clinical translation of this technology. In this context, the first investigations of bioengineered vascular grafts in immune-incompetent or transgenic rodents represented an important step. However, the in-vivo assessment of bioengineered synthetic scaffold-based (biodegradable) valve replacements in rodent models has not been achieved to date...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27976797/comparable-vascular-response-of-a-new-generation-sirolimus-eluting-stents-when-compared-to-fluoropolymer-everolimus-eluting-stents-in-the-porcine-coronary-restenosis-model
#8
Piotr P Buszman, Magdalena J Michalak, Maciej Pruski, Carlos Fernandez, Michał Jelonek, Adam Janas, Claudine Savard, Beata Gwiazdowska-Nowotka, Aleksander Żurakowski, Wojciech Wojakowski, Paweł E Buszman, Krzysztof Milewski
BACKGROUND: Novel sirolimus eluting stents (SES) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (EES), however only limited preclinical data have been published. Therefore, we evaluate vascular response of a new generation biodegradable polymer SES (BP-SES: Alex Plus, Balton) and fluoropolymer EES (EES: Xience Pro, Abbott) in the porcine coronary restenosis model. METHODS: A total of 40 stents were implanted with 120% overstretch in coronaries of 17 domestic swine: 16 BP-SES, 16 EES and 8 bare metal controls (BMS)...
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27970269/tct-106-outcomes-after-revascularization-with-sirolimus-eluting-and-birolimus-eluting-stents-with-biodegradable-polymer-in-patients-with-acute-coronary-syndromes-from-the-sort-out-vii-trial
#9
Christian Oliver Fallesen, Evald Christiansen, Hans Erik Bøtker, Bent Raungaard, Michael Maeng, Anders Junker, Lars Jakobsen, Svend Eggert Jensen, Johnny Kahlert, Lisette Okkels Jensen
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970227/tct-836-endothelial-cell-coverage-and-inflammation-comparing-cobra-polyzene-f-pzf-coated-stent-to-durable-fluoropolymer-and-biodegradable-polymer-drug-eluting-stents-in-a-rabbit-model
#10
Kazuyuki Yahagi, Frank Kolodgie, Daivid Cheng, Eduardo Acampado, Hiroyoshi Mori, Khaja Chinnakondepali, Maria Romero, Aloke Finn, Renu Virmani
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970224/tct-835-endothelial-function-assessed-by-expression-of-adherens-junctions-and-inflammation-between-durable-and-biodegradable-polymer-drug-eluting-stents-in-the-rabbit-iliofemoral-model
#11
Kazuyuki Yahagi, Frank Kolodgie, Daivid Cheng, Eduardo Acampado, Liang Guo, Hiroyoshi Mori, Khaja Chinnakondepali, Maria Romero, Laura Perkins, Aloke Finn, Renu Virmani
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970070/tct-69-a-randomized-comparison-of-the-second-generation-biodegradable-polymer-sirolimus-eluting-stent-excel-ii-and-the-first-generation-excel-i-stent-in-patients-with-de-novo-coronary-lesions-clinical-and-angiographic-outcomes-of-the-credit-ii-trial
#12
Yaling Han, Yuejin Yang, Bo Xu, Yong Sun, Zuyi Yuan, Haichang Wang, Jinghua Liu, Huiliang Liu, Genshan Ma, Geng Wang, Quanmin Jing, Xiaozeng Wang
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970069/tct-70-final-5-year-results-from-the-compare-ii-trial-comparison-between-the-durable-polymer-coated-everolimus-eluting-xience-promus-stent-and-the-biodegradable-polymer-coated-biolimus-eluting-nobori-stent-in-all-comer-population
#13
Pieter Smits, Sjoerd H Hofma, Mario Togni, Peter den Heijer, Antonio Serra, Ton Slagboom, Ramiro Trillo, Mariano Valdes, Jose Vazquez, Vassilis Voudris
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969930/tct-561-long-term-vascular-response-to-permanent-polymer-everolimus-eluting-stent-vs-biodegradable-polymer-biolimus-eluting-stent-five-year-follow-up-optical-coherence-tomography-study
#14
Shoichi Kuramitsu, Shinjo Sonoda, Hiroyuki Jinnouchi, Yoshitaka Muraoka, Takenori Domei, Shinichi Shirai, Kenji Ando
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969853/tct-495-a-prospective-9-month-comparison-of-the-coronary-vasomotor-response-associated-with-a-biodegradable-polymer-sirolimus-eluting-stent-and-a-bare-metal-stent
#15
Rodrigo Souza, Adriano Barbosa, Marco Tulio Souza, Marcelo Parente, Bárbara Freitas Fiorin, Jose Marconi Almeida Sousa, Claudia Alves, Adriano Caixeta, Antonio Carlos Carvalho
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969852/tct-494-very-long-term-8-year-angiographic-and-clinical-outcomes-after-biodegradable-polymer-based-biolimus-eluting-stent-implantation
#16
Masanobu Ohya, Akimune Kuwayama, Katsuya Miura, Takenobu Shimada, Hidewo Amano, Shunsuke Kubo, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969841/tct-485-a-study-of-safety-and-efficacy-of-biodegradable-polymer-coated-everolimus-eluting-coronary-stent-system-everoflex-at-intermediate-follow-up-in-real-world-scenario
#17
Rajasekhar Durgaprasad, Velam Vanajakshamma, A Vamsidhar, Latheef Kasala, Sreedhar Naik Kanavat, Pathakota Sudhakar Reddy
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969833/tct-476-a-randomized-comparison-of-novel-biodegradable-polymer-and-durable-polymer-coated-cobalt-chromium-sirolimus-eluting-stents-three-year-outcomes-of-the-i-love-it-2-trial
#18
Bo Xu, Changdong Guan, Quanmin Jing, Kai Xu, Yuejin Yang, Yaling Han
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969832/tct-473-a-randomized-comparison-of-biodegradable-polymer-and-permanent-polymer-coated-platinum-chromium-everolimus-eluting-coronary-stents-in-china-evolve-china-study
#19
Yaling Han, Yuejin Yang, Guosheng Fu, X I Su, Tiemin Jiang, Wenyue Pang, Jiyan Chen, Zuyi Yuan, Haichang Wang, Huiliang Liu, Mingdong Zhang, Rider Brito Filho
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969825/tct-468-acute-thrombogenicity-and-inflammation-in-response-to-a-durable%C3%A2-fluoropolymer-everolimus-eluting-stent-relative-to-a%C3%A2-contemporary-sirolimus-eluting-stent-with-an-abluminal-biodegradable-polymer-coating
#20
Sho Torii, Frank Kolodgie, Daivid Cheng, Eduardo Acampado, Kazuyuki Yahagi, Hiroyoshi Mori, Maria Romero, Laura Perkins, Syed Hossainy, Stephen Pacetti, Aloke Finn, Renu Virmani
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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