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Biodegradable stents

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https://www.readbyqxmd.com/read/29160048/from-biodegradable-polymers-to-bioresorbable-vascular-scaffolds-available-evidence-in-the-current-era-of-new-generation-des
#1
Fabio Magliulo, Raffaele Piccolo, Anna Franzone, Giovanni Esposito, Gian B Danzi
New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts, biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicate a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES...
November 20, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29159531/very-early-neointimal-coverage-of-new-biodegradable-polymer-drug-eluting-stent-compared-with-durable-polymer-everolimus-eluting-stent-evaluated-by-optical-frequency-domain-imaging
#2
Norihiro Kobayashi, Yoshiaki Ito, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Masahiro Nauchi, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Keisuke Hirano
Polymeric component is associated with the increased risk of delayed vessel healing and stent endothelialization. We aimed to clarify neointimal coverage within 1 month after implantation of the new-generation abluminal biodegradable polymer (BP) drug-eluting stent (DES) compared with the second-generation durable polymer (DP) everolimus-eluting stent (EES). Between November 2015 and October 2016, 32 BP-DES and 25 DP-EES were evaluated by optical frequency domain imaging (OFDI) within 1 month after the procedure...
November 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29128964/in-vivo-assessment-of-a-novel-biodegradable-ureteral-stent
#3
Alexandre A Barros, Carlos Oliveira, Ana J Ribeiro, Riccardo Autorino, Rui L Reis, Ana Rita C Duarte, Estevão Lima
PURPOSE: To perform an in vivo assessment of a newly developed biodegradable ureteral stent (BUS) produced with natural-based polymers. METHODS: The BUS is based on a patented technology combining the injection process with the use of supercritical fluid technology. Study was conducted at ICVS-University of Minho (Braga, Portugal) and a total of ten domestic pigs were used. In seven animals, the experimental BUS stent was inserted, whereas in the remaining a commercially available stent was used (6-Fr Biosoft(®) duo stents, Porges Coloplast, Denmark)...
November 11, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29128386/a-pilot-study-of-endoscopically-inserted-biodegradable-biliary-stents-in-the-treatment-of-benign-biliary-strictures-and-cystic-duct-leaks
#4
Antti Siiki, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
BACKGROUND AND AIMS: Self-expanding biodegradable biliary stents (BDBSs) have recently become available for use in endoscopic retrograde cholangiography (ERC). The aim was to evaluate the effectiveness and safety of novel BDBS in iatrogenic cystic duct leaks and benign biliary strictures (BBSs). MATERIALS AND METHODS: Patients providing informed consent were recruited for the prospective study. Braided self-expanding poly-dioxanone BDBSs were inserted in ERC during the period 2012 to 2016...
November 8, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29102583/endothelial-barrier-protein-expression-in-biodegradable-polymer-sirolimus-eluting-versus-durable-polymer-everolimus-eluting-metallic-stents
#5
Hiroyoshi Mori, Qi Cheng, Christoph Lutter, Samantha Smith, Liang Guo, Matthew Kutyna, Sho Torii, Emanuel Harari, Eduardo Acampado, Michael Joner, Frank D Kolodgie, Renu Virmani, Aloke V Finn
OBJECTIVES: This study sought to investigate endothelial coverage and barrier protein expression following stent implantation. BACKGROUND: Biodegradable polymer drug-eluting stents (BP-DES) have been purported to have biological advantages in vessel healing versus durable polymer DES (DP-DES), although clinical trial data suggest equipoise. METHODS: Biodegradable polymer-sirolimus-eluting stents (BP-SES), durable polymer-everolimus-eluting stents (DP-EES), and bare-metal stents (BMS) were compared...
October 25, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29101374/a-comparison-of-the-main-outcomes-from-bp-bes-and-dp-des-at-five-years-of-follow-up-a-systematic-review-and-meta-analysis
#6
Pan Lu, Shuai Lu, Yuanyuan Li, Mengmeng Deng, Zhaohui Wang, Xiaobo Mao
Biodegradable polymer biolimus-eluting stents (BP-BES) are third-generation drug-eluting stents (DES) composed of biodegradable polymers that may improve prognosis after percutaneous coronary intervention (PCI). After five years of follow-up, BP-BES showed conflicting results compared to durable polymer drug-eluting stents (DP-DES). We performed a meta-analysis of the outcomes of studies on BP-BES and DP-DES after percutaneous coronary intervention (PCI) at five years of follow-up. Eligible studies were retrieved from PubMed, Embase and the Cochrane Library and reported the results of all-cause mortality, myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR) and stent thrombosis (ST) at five years of follow-up...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29082870/biodegradable-polymer-drug-eluting-stents-caveat-emptor
#7
Robert A Byrne, Tibor Schuster
No abstract text is available yet for this article.
October 21, 2017: Lancet
https://www.readbyqxmd.com/read/29066243/sustained-local-delivery-of-high-concentration-vancomycin-from-a-hybrid-biodegradable-antibiotic-eluting-nanofiber-loaded-endovascular-prosthesis-for-treatment-of-mycotic-aortic-aneurysms
#8
Kuo-Sheng Liu, Cheng-Hung Lee, Demei Lee, Michelle Liu, Feng-Chun Tsai, Yuan-Yun Tseng
BACKGROUND: Endovascular repair for mycotic aortic aneurysm (MAA) is a less invasive alternative to open surgery, although the placement of a stent graft in an infected environment remains controversial. In this study, we developed hybrid biodegradable, vancomycin-eluting, nanofiber-loaded endovascular prostheses and evaluated antibiotic release from the endovascular prostheses both in vitro and in vivo. METHODS: Poly(D,L)-lactide-co-glycolide and vancomycin were dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol...
October 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29050135/-research-progress-of-biodegradable-trachea-stent
#9
J M Niu, J Zhang
No abstract text is available yet for this article.
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29033836/delivery-of-antioxidant-and-anti-inflammatory-agents-for-tissue-engineered-vascular-grafts
#10
REVIEW
Kenyatta S Washington, Chris A Bashur
The treatment of patients with severe coronary and peripheral artery disease represents a significant clinical need, especially for those patients that require a bypass graft and do not have viable veins for autologous grafting. Tissue engineering is being investigated to generate an alternative graft. While tissue engineering requires surgical intervention, the release of pharmacological agents is also an important part of many tissue engineering strategies. Delivery of these agents offers the potential to overcome the major concerns for graft patency and viability...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29027737/an-optical-coherence-tomography-study-of-neointimal-morphology-and-strut-coverage-at-different-time-intervals-from-implantation-of-biodegradable-polymer-coated-sirolimus-eluting-stents
#11
Jacek Legutko, Robert J Gil, Pawel E Buszman, Grzegorz L Kaluza, Gary S Mintz, Tomasz Roleder, Marek Krol, Roman Wojdyla, Tomasz Pawlowski, Michal Brzezinski, Marek Kondys, Bartosz Skwarna, Jacek Jakala, Wojciech Zasada, Lukasz Partyka, Dariusz Dudek
OBJECTIVES: The aim of the study was to capture the evolution of neointima after implantation of a biodegradable polymer-coated, sirolimus-eluting, cobalt-chromium coronary stent system (BP-DES). BACKGROUND: Optical coherence tomography (OCT) suggests that in-stent neointimal morphology influences clinical outcomes after DES implantation. METHODS: Sixty patients treated with single BP-DES implantation were examined by quantitative coronary angiography (QCA) and OCT at 3, 6, and 12-month follow-up...
October 13, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29025834/study-protocol-for-a-randomised-controlled-trial-harmonising-optimal-strategy-for-treatment-of-coronary-artery-stenosis-coronary-intervention-with-next-generation-drug-eluting-stent-platforms-and-abbreviated-dual-antiplatelet-therapy-host-idea-trial
#12
Chi-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Namho Lee, Tae-Joon Cha, Tae-Hyun Yang, Myung-Ho Jeong, Myeong-Ho Yoon, Seung Uk Lee, Seung Jin Lee, Jin Won Kim, Jin-Man Cho, Kyu-Rock Han, Wook Bum Pyun, Hyo-Soo Kim
INTRODUCTION: We have recently seen the introduction of newer generation drug-eluting stents with ultrathin struts that use advanced polymer technologies. However, the efficacy and safety of these newest stents have not yet been fully explored. In addition, there are still controversies over the optimal duration of dual antiplatelet therapy (DAPT) after stent implantation, particularly for ultrathin stents with the newest polymer technologies. METHODS AND ANALYSIS: The HOST-IDEA trial is a randomised, open-label, multicentre, non-inferiority trial and the first study to directly compare two of these ultrathin sirolimus-eluting stents: Orsiro stent with biodegradable polymer, and polymer-free Coroflex ISAR (CX-ISAR) stent...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29020300/impact-of-design-of-coronary-stents-and-length-of-dual-antiplatelet-therapies-on-ischaemic-and-bleeding-events-a-network-meta-analysis-of-64-randomized-controlled-trials-and-102%C3%A2-735-patients
#13
Fabrizio D'Ascenzo, Mario Iannaccone, Gaelle Saint-Hilary, Maurizio Bertaina, Stefanie Schulz-Schüpke, Cheol Wahn Lee, Alaide Chieffo, Gerard Helft, Sebastiano Gili, Umberto Barbero, Giuseppe Biondi Zoccai, Claudio Moretti, Fabrizio Ugo, Maurizio D'Amico, Roberto Garbo, Gregg Stone, Sara Rettegno, Pierluigi Omedè, Federico Conrotto, Christian Templin, Antonio Colombo, Seung-Jung Park, Adnan Kastrati, David Hildick-Smith, Mauro Gasparini, Fiorenzo Gaita
Aims: The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results: Randomized controlled trials comparing different types of DES and/or DAPT durations were selected. The primary endpoint was Major Adverse Cardiovascular Events (MACE) [a composite of death, myocardial infarction (MI), and target vessel revascularization]...
November 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28994804/biodegradable-magnesium-stent-treatment-of-saccular-aneurysms-in-a-rat-model-introduction-of-the-surgical-technique
#14
Edin Nevzati, Jeannine Rey, Daniel Coluccia, Donato D'Alonzo, Basil Grüter, Luca Remonda, Javier Fandino, Serge Marbacher
The steady progess in the armamentarium of techniques available for endovascular treatment of intracranial aneurysms requires affordable and reproducable experimental animal models to test novel embolization materials such as stents and flow diverters. The aim of the present project was to design a safe, fast, and standardized surgical technique for stent assisted embolization of saccular aneurysms in a rat animal model. Saccular aneurysms were created from an arterial graft from the descending aorta.The aneurysms were microsurgically transplanted through end-to-side anastomosis to the infrarenal abdominal aorta of a syngenic male Wistar rat weighing >500 g...
October 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28994655/functional-comparison-between-buma-supreme-biodegradable-polymer-sirolimus-eluting-and-durable-polymer-zotarolimus-eluting-coronary-stents-using-quantitative-flow-ratio-pioneer-qfr-substudy
#15
Taku Asano, Yuki Katagiri, Carlos Collet, Erhan Tenekecioglu, Yosuke Miyazaki, Yohei Sotomi, Giovanni Amoroso, Adel Aminian, Salvatore Brugaletta, Mathias Vrolix, Rosana Hernandez-Antolín, Pim van de Harst, Andres Iñiguez, Luc Janssens, Pieter Smits, Joanna J Wykrzykowska, Vasco Gama Ribeiro, Helder Periera, Pedro Canas da Silva, Jan J Piek, Johan H C Reiber, Clemens von Birgelen, Manel Sabaté, Yoshinobu Onuma, Patrick W Serruys
AIMS: Quantitative Flow Ratio (QFR) based on 3-dimensional quantitative coronary angiography (3D-QCA) is a novel method to assess the physiological functionality after treatment with stents. The current study aimed to evaluate the difference in physiological functionality 9 months after implantation of a bioresorbable polymer-based sirolimus-eluting stent with an electrografting base layer (BuMA Supreme: B-SES) versus a durable polymer-based zotarolimus-eluting stent (Resolute: R-ZES)...
October 10, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28990450/revisiting-the-role-of-durable-polymers-in-cardiovascular-devices
#16
Hiroyoshi Mori, Fumiyuki Otsuka, Anuj Gupta, Hiroyuki Jinnouchi, Sho Torii, Emanuel Harari, Renu Virmani, Aloke V Finn
Polymers are an essential component of drug-eluting stents (DES) used to control drug release but remain the most controversial component of DES technology. There are two types of polymers employed in DES: durable polymer based DES (DP-DES) and biodegradable polymer DES (BP-DES). First-generation DES were exclusively composed of DP and demonstrated increased rates of late stent failure due in part to poor polymer biocompatibility. Newer generations DES use more biocompatible durable polymers or biodegradable polymers...
November 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28990343/efficacy-and-safety-of-a-biodegradable-polymer-cobalt-chromium-sirolimus-eluting-stent-excel2-in-treating-de-novo-coronary-artery-disease-a-pooled-analysis-of-the-credit-ii-and-credit-iii-trials-doi-10-1002-ccd-26887
#17
Geng Wang, Heyang Wang, Bo Xu, Yuejin Yang, Zhiming Yang, Hui Li, Zheng Zhang, Haichang Wang, Lixia Yang, Yaling Han
No abstract text is available yet for this article.
October 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28972745/monoether-tagged-biodegradable-polycarbonate-preventing-platelet-adhesion-and-demonstrating-vascular-cell-adhesion-a-promising-material-for-resorbable-vascular-grafts-and-stents
#18
Kazuki Fukushima, Yuto Inoue, Yuta Haga, Takayuki Ota, Kota Honda, Chikako Sato, Masaru Tanaka
We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower than those of poly(ethylene terephthalate) and polyTMC, respectively. In contrast, vascular cell adhesion properties of the polycarbonate are comparable to those controls, indicating a potential for selective cell adhesion properties...
October 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28965166/comparative-assessment-of-three-drug-eluting-stents-with-different-platforms-but-with-the-same-biodegradable-polymer-and-the-drug-based-on-quantitative-coronary-angiography-and-optical-coherence-tomography-at-12-month-follow-up
#19
Robert J Gil, Jacek Bil, Jacek Legutko, Tomasz Pawłowski, Katarzyna E Gil, Dariusz Dudek, Ricardo A Costa
The aim of this study was to compare neointima proliferation in three drug-eluting stents (DES) produced by the same company (Balton, Poland) which are covered with a biodegradable polymer and elute sirolimus (concentration: 1.0 and 1.2 µg/mm(2)), but have different stent platforms and strut thickness: stainless steel Prolim(®) (115 µm) and BiOSS LIM(®) (120 µm) and cobalt-chromium Alex(®) (70 µm). We analyzed data of patients with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 12 months from BiOSS LIM Registry, Prolim Registry and Alex OCT clinical trial...
September 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28948892/clinical-protocol-levels-are-required-in-laboratory-animal-surgery-when-using-medical-devices-experiences-with-ureteral-replacement-surgery-in-goats
#20
Paul K J D de Jonge, Marije Sloff, Heinz P Janke, Barbara B M Kortmann, Robert P E de Gier, Paul J Geutjes, Egbert Oosterwijk, Wout F J Feitz
It is common to test medical devices in large animal studies that are or could also be used in humans. In this short report we describe the use of a ureteral J-stent for the evaluation of biodegradable tubular constructs for tissue reconstruction, and the regeneration of ureters in Saanen goats. Similarly to a previous study in pigs, the ureteral J-stent was blindly inserted until some resistance was met. During evaluation of the goats after three months, perforation of the renal cortex by the stent was observed in four out of seven animals...
October 2017: Laboratory Animals
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