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Biodegradable stents

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https://www.readbyqxmd.com/read/28424763/airway-problems-in-neonates-a-review-of-the-current-investigation-and-management-strategies
#1
REVIEW
Quen Mok
Airway problems in the neonatal population are often life threatening and raise challenging issues in diagnosis and management. The airway problems can result from congenital or acquired lesions and can be broadly classified into those causing obstruction or those due to an abnormal "communication" in the airway. Many different investigations are now available to identify the diagnosis and quantify the severity of the problem, and these tests can be simple or invasive. Bronchography and bronchoscopy are essential to determine the extent and severity of the airway problem and to plan treatment strategy...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28408454/bioresorbable-scaffold-the-emerging-reality-and-future-directions
#2
REVIEW
Yohei Sotomi, Yoshinobu Onuma, Carlos Collet, Erhan Tenekecioglu, Renu Virmani, Neal S Kleiman, Patrick W Serruys
In the era of drug-eluting stents, large-scale randomized trials and all-comer registries have shown excellent clinical results. However, even the latest-generation drug-eluting stent has not managed to address all the limitations of permanent metallic coronary stents, such as the risks of target lesion revascularization, neoatherosclerosis, preclusion of late lumen enlargement, and the lack of reactive vasomotion. Furthermore, the risk of very late stent, although substantially reduced with newer-generation drug-eluting stent, still remains...
April 14, 2017: Circulation Research
https://www.readbyqxmd.com/read/28402204/evaluation-of-the-mistent-sustained-sirolimus-eluting-biodegradable-polymer-coated-stent-for-the-treatment-of-coronary-artery-disease-does-uniform-sustained-abluminal-drug-release-result-in-earlier-strut-coverage-and-better-safety-profile
#3
Ruben Y G Tijssen, Robin P Kraak, Huangling Lu, Jeffrey G Mifek, Wenda C Carlyle, Dennis J Donohoe, Robbert J de Winter, Karel T Koch, Joanna J Wykrzykowska
Treatment of coronary artery disease has made strides over the last decades. Development of drug eluting stents (DES), coated with a polymer layer and an anti-proliferative drug to reduce neointimal hyperplasia, has reduced the incidence of in-stent-restenosis relative to treatment with bare metal stents. Patients treated with first generation DES more likely suffer from (very) late events which can be cause by the permanent presence of a polymer. Therefore second generation DES with more biocompatible coatings, and third generation DES, with very thin struts coated with biodegradable polymers, were developed...
April 12, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28397881/a-promising-biodegradable-magnesium-alloy-suitable-for-clinical-vascular-stent-application
#4
Lin Mao, Li Shen, Jiahui Chen, Xiaobo Zhang, Minsuk Kwak, Yu Wu, Rong Fan, Lei Zhang, Jia Pei, Guangyin Yuan, Chengli Song, Junbo Ge, Wenjiang Ding
We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% respectively. The JDBM-2 with a stable degradation surface results in a highly homogeneous degradation mechanism and long-term structural and mechanical durability. In vitro cytotoxicity test of the Mg extract via human vascular endothelial cells (HUVECs) indicates that the corrosion products are well tolerated by the tested cells and potentially negligible toxic effect on arterial vessel walls...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394644/bioss-lim-c-thin-strut-cobalt-chromium-version-of-the-dedicated-bifurcation-stent
#5
Robert J Gil, Jacek Bil, Mateusz Kaczynski, Krzysztof P Milewski
Coronary bifurcation lesions pose therapeutic challenges during percutaneous coronary interventions. Dedicated bifurcation stents are one of the treatment options available. Areas covered: This paper will analyze the results of the BiOSS (Bifurcation Optimization Stent System) Clinical Program with a special focus on the cobalt-chromium BiOSS LIM C stent which has recently been introduced into the market (CE 2016). The stent is characterized by a strut thickness of 70 µm and sirolimus concentration of 1.4 µg/mm(2)...
April 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28394518/-the-study-of-effectiveness-of-polyhydroxyalkanoates-based-biodegradable-stents-in-ureteropelvic-segment-pyeloplasty
#6
M P Myltygashev, A N Boyandin, A A Shumilova, F P Kapsargin, E I Shishatskaya, A K Kirichenko, T G Volova
INTRODUCTION: Among urologic diseases, ureteropelvic segment stenosis with hydronephrosis is a common indication for instrumental or surgical correction. The restriction of urine flow with dilatation proximal to obstruction develops in 6.5-37% of cases at different times after the ureteral reconstruction. All this urges to develop and improve stents and search for effective ways to place stents and control their function. AIM: To investigate the effectiveness of polyhydroxyalkanoates based biodegradable stent compared with a commercial analogue in upper urinary tract drainage after ureteropelvic segment pyeloplasty...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28379855/mid-term-outcome-of-biolimus-eluting-stents-with-biodegradable-polymer-results-from-a-multinational-prospective-all-comers-registry
#7
Evgeniy I Kretov, Vitaly I Baystrukov, Marouane Boukhris, Alexey A Prokhorikhin, Igor O Grazhdankin, Farouk Abcha, Alexey V Biryukov, Vladimir V Verin, Dmitriy D Zubarev, Roman A Naydenov, Ivan A Naryshkin, Dmitriy N Ponomarev, Sharaf E Mahmoud, Alfredo R Galassi, Anton A Obedinskiy
BACKGROUND: The Nobori biolimus-eluting stent (BES) is a biodegradable polymer drug-eluting stent (DES). Several studies have shown its noninferiority in comparison with durable polymer DES. AIM: We sought to investigate the efficacy and the safety of Nobori BES in an all-comer population undergoing a percutaneous coronary intervention. PATIENTS AND METHODS: A total of 12 912 patients with 19 947 coronary lesions, undergoing percutaneous coronary intervention with Nobori BES implantation at 200 centres around the world between August 2010 and December 2015, were included in this prospective registry...
April 4, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28322012/3d-printed-multidrug-eluting-stent-from-graphene-nanoplatelet-doped-biodegradable-polymer-composite
#8
Santosh K Misra, Fatemeh Ostadhossein, Ramya Babu, Joseph Kus, Divya Tankasala, Andre Sutrisno, Kathleen A Walsh, Corinne R Bromfield, Dipanjan Pan
Patients with percutaneous coronary intervention generally receive either bare metal stents or drug-eluting stents to restore the normal blood flow. However, due to the lack of stent production with an individual patient in mind, the same level of effectiveness may not be possible in treating two different clinical scenarios. This study introduces for the first time the feasibility of a patient-specific stenting process constructed from direct 3D segmentation of medical images using direct 3D printing of biodegradable polymer-graphene composite with dual drug incorporation...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28318138/safety-and-efficacy-of-6-month-versus-12-month-dual-antiplatelet-therapy-in-patients-after-implantation-of-multiple-biodegradable-polymer-coated-sirolimus-eluting-coronary-stents-insight-from-the-i-love-it-2-trial
#9
RANDOMIZED CONTROLLED TRIAL
Jing Qi, Yi Li, Jing Li, Quanmin Jing, Kai Xu, Chuanyu Gao, Likun Ma, Zhi Zhang, Bo Xu, Yaling Han
OBJECTIVE: This study sought to compare the clinical outcomes of 6-month versus 12-month dual antiplatelet therapy (DAPT) in patients receiving multiple biodegradable polymer-coated sirolimus-eluting stents (BP-SES) implants. BACKGROUND: The clinical outcomes for patients who undergo multiple BP-SES implantation with different DAPT durations are uncertain. METHODS: In the I-LOVE-IT 2 trial, 907 patients treated with multiple BP-SES (total stent number ≥2) were assigned to receive 6-month (n = 440) or 12-month (n = 467) DAPT...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28302466/bioflow-iii-satellite-one-year-clinical-outcomes-of-diabetic-patients-treated-with-a-biodegradable-polymer-sirolimus-eluting-stent-and-comprehensive-medical-surveillance
#10
Ran Kornowski, Ariel Roguin, Haim Danenberg, Hana Vaknin Assa, Eitan Abergel, Eliezer Rozenbaum, Victor Guetta, Uri Landes, Refat Jabara, Amnon Merdler, Amit Segev, Morris Mosseri, Abid Assali
BACKGROUND: Drug-eluting stents with biodegradable polymer might be particularly useful in diabetic patients who are at increased risk for target lesion/target vessel revascularization. We therefore aimed at assessing the safety and performance of a biodegradable polymer sirolimus-eluting stent (BP-SES) in combination with comprehensive optimal medical therapy following coronary interventions. METHODS: This prospective, multicenter registry was conducted at six centers in Israel...
February 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28286555/silicone-covered-biodegradable-magnesium-stent-insertion-in-the-esophagus-a-comparison-with-plastic-stents
#11
Yue-Qi Zhu, Kai Yang, Laura Edmonds, Li-Ming Wei, Reila Zheng, Ruo-Yu Cheng, Wen-Guo Cui, Ying-Sheng Cheng
BACKGROUND: We determined the feasibility of, and tissue response to silicone-covered biodegradable magnesium- and plastic-stent insertion into the esophagus in rabbits. METHODS: The mechanical compression-recovery characteristics and degradation behaviors of the magnesium stent were investigated in vitro. A total of 45 rabbits were randomly divided into a magnesium- (n = 15) and a plastic- (n = 15) stent group, and underwent stent insertion into the lower third of the esophagus under fluoroscopic guidance; a control group (n = 15) did not undergo the intervention...
January 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28284499/the-optimal-discontinuation-of-dual-antiplatelet-therapy-in-patients-undergoing-percutaneous-coronary-intervention-with-drug-eluting-stents-a-meta-analysis-of-randomized-trials
#12
Wei Wang, Jing Liu, Jingxue Fang, Yang Liu, Tong An, Meijuan Zou, Gang Cheng
BACKGROUND: Current guidelines recommend prolonged dual antiplatelet therapy (DAPT) for patients with drug-eluting stents (DES) implantation. Nevertheless, optimal discontinuation of DAPT remains a controversy. We performed a meta-analysis of all randomized controlled trials (RCTs) that evaluate optimal discontinuation of DAPT in patients undergoing percutaneous coronary intervention (PCI) with DES. METHODS: We searched electronic databases including PubMed, Cochrane Library, EMBASE and ClinicalTrials...
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28281415/use-of-a-biodegradable-oversized-stent-in-a-child-with-tracheomalacia-secondary-to-vascular-external-compression
#13
Giovanni Di Dedda, Cristian Mirabile
We describe the implantation of an absorbable, custom-made stent of polydioxanone to treat tracheomalacia in a 5-month-old patient with extrinsic compression by a double aortic arch. The use of an absorbable, oversized stent treated the tracheal collapse caused by vascular compression, avoided removal procedures, and allowed the infant's growth. The use of an oversized stent prevented stent migration and gave minimal problems of granulation.
January 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28279315/biodegradable-polymer-drug-eluting-stents-can-a-class-effect-be-assumed
#14
EDITORIAL
Jeffrey W Moses, Vivian G Ng
No abstract text is available yet for this article.
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28279314/meta-analysis-of-randomized-clinical-trials-comparing-biodegradable-polymer-drug-eluting-stent-to-second-generation-durable-polymer-drug-eluting-stents
#15
Georges El-Hayek, Sripal Bangalore, Abel Casso Dominguez, Chandan Devireddy, Wissam Jaber, Gautam Kumar, Kreton Mavromatis, Jacqueline Tamis-Holland, Habib Samady
OBJECTIVES: The authors sought to perform a meta-analysis of randomized clinical trials (RCTs) comparing the safety and efficacy of biodegradable polymer drug-eluting stents (BP-DES) to second-generation durable polymer drug-eluting stents (DP-DES). BACKGROUND: Prior meta-analyses have established the superiority of BP-DES over bare-metal stents and first-generation DP-DES; however, their advantage compared with second-generation DP-DES remains controversial. METHODS: The authors searched PubMed and Scopus databases for RCTs comparing BP-DES to the second-generation DP-DES...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28274192/immersed-multilayer-biodegradable-ureteral-stent-with-reformed-biodegradation-an-in-vitro-experiment
#16
Ganggang Yang, Hua Xie, Yichen Huang, Yiqing Lv, Mingqing Zhang, Yafeng Shang, Junmei Zhou, Liping Wang, Jin-Ye Wang, Fang Chen
Objective The aim of this study was to develop a novel immersed multilayer biodegradable ureteral stent with reformed biodegradation and evaluate it in vitro. Methods Poly(glycolic-co-lactic acid) (PGLA), microsphere zein and BaSO4 were employed to produce a multilayer biodegradable stent using immersion technology. Tests of the biodegradable stents and conventional control stents were conducted in human urine in vitro to evaluate the biodegradable properties. The biocompatibility was assessed by the morphology and proliferation of urine-derived cells cultured with extracted media from the biodegradable stent and a latex material positive control...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28273914/biodegradable-cable-tie-rapamycin-eluting-stents
#17
Cheng-Hung Lee, Ming-Jer Hsieh, Shang-Hung Chang, Chang-Lin Chiang, Ching-Lung Fan, Shih-Jung Liu, Wei-Jan Chen, Chao-Jan Wang, Ming-Yi Hsu, Kuo-Chun Hung, Chung-Chuan Chou, Po-Cheng Chang
"Cable-tie" type biodegradable stents with drug-eluting nanofiber were developed to treat rabbit denuded arteries in this study. Biodegradable stents were fabricated using poly-L-lactide film following being cut and rolled into a cable-tie type stent. Additionally, drug-eluting biodegradable nanofiber tubes were electrospun from a solution containing poly (lactic-co-glycolic acid), rapamycin, and hexafluoroisopropanol, and then mounted onto the stents. The fabricated rapamycin-eluting cable-tie stents exhibited excellent mechanical properties on evaluation of compression test and collapse pressure, and less than 8% weight loss following being immersed in phosphate-buffered saline for 16 weeks...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28264515/fabrication-and-optimal-design-of-biodegradable-polymeric-stents-for-aneurysms-treatments
#18
Xue Han, Xia Wu, Michael Kelly, Xiongbiao Chen
An aneurysm is a balloon-like bulge in the wall of blood vessels, occurring in major arteries of the heart and brain. Biodegradable polymeric stent-assisted coiling is expected to be the ideal treatment of wide-neck complex aneurysms. This paper presents the development of methods to fabricate and optimally design biodegradable polymeric stents for aneurysms treatment. Firstly, a dispensing-based rapid prototyping (DBRP) system was developed to fabricate coil and zigzag structures of biodegradable polymeric stents...
February 28, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28262439/in-reply-biodegradable-stent-for-vanishing-bronchus-syndrome-after-lung-transplantation
#19
EDITORIAL
Sebastian Fernandez-Bussy, Gonzalo Labarca, Adnan Majid
No abstract text is available yet for this article.
February 3, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28257819/in-vitro-and-ex-vivo-permeability-studies-of-paclitaxel-and-doxorubicin-from-drug-eluting-biodegradable-ureteral-stents
#20
Alexandre A Barros, Carlos Oliveira, Rui L Reis, Estevão Lima, Ana Rita C Duarte
A drug-eluting biodegradable ureteral stent (BUS) has been developed as a new approach for the treatment of urothelial tumors of upper urinary tract cancer. In a previous work, this system has proven to be a good carrier for anticancer drugs as a potential effective and sustainable intravesical drug delivery (IDD) system. BUS has revealed to reduce in 75% the viability of human urothelial cancer cells (T24) after 72 h of contact and demonstrated minimal cytotoxic effect on human umbilical vein endothelial cells (HUVECs) which were used as a control...
February 28, 2017: Journal of Pharmaceutical Sciences
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