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Biodegradable stents

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https://www.readbyqxmd.com/read/27923461/impact-of-patient-and-lesion-complexity-on-long-term-outcomes-following-coronary-revascularization-with-new-generation-drug-eluting-stents
#1
Konstantinos C Koskinas, Masanori Taniwaki, Fabio Rigamonti, Dik Heg, Marco Roffi, David Tüller, Olivier Muller, Andre Vuillomenet, Stephane Cook, Daniel Weilenmann, Christopher Kaiser, Peiman Jamshidi, Peter Jüni, Stephan Windecker, Thomas Pilgrim
Long-term clinical outcomes of new-generation drug-eluting stents in complex anatomic and clinical settings are not well defined. This study assessed the impact of patient and lesion complexity on 2-year outcomes after coronary revascularization with ultrathin strut biodegradable-polymer (BP) sirolimus-eluting stents (SES) versus durable-polymer (DP) everolimus-eluting stents (EES). In a prespecified analysis of the BIOSCIENCE randomized trial (NCT01443104), complex patients (911 of 2,119; 43%) were defined by the presence of acute ST-elevation myocardial infarction (MI); left ventricular ejection fraction ≤30%; renal dysfunction; insulin-treated diabetes; treatment of ostial lesion, bypass graft, unprotected left main lesion; or 3-vessel intervention...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27875036/drug-loaded-nanoparticle-coating-on-totally-bioresorbable-plla-stents-to-prevent-in-stent-restenosis
#2
Jian Zhao, Zhichao Mo, Fangfang Guo, Donglu Shi, Qian Qian Han, Qing Liu
Biodegradable polymer poly (dl-lactide) (PDLLA) has been used as drug coating material for drug-eluting stents due to its excellent biocompatibility and sustained drug release ability. However, the uniform thin layer drug eluting coating on a stent not only inhibits the blood vessel's smooth muscle cell overgrowth but also delay the endotheliation process which is often associated with the occurrence of acute thrombosis. Therefore, in this study, we developed a novel coating method using PDLLA nanoparticles (NPs) as a coating to overcome this issue...
November 22, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27872316/outcomes-of-acute-myocardial-infarction-patients-implanted-with-biodegradable-polymer-biolimus-eluting-stents-versus-new-generation-durable-polymer-drug-eluting-stents-a-retrospective-analysis
#3
Jeong Cheon Choe, Kwang Soo Cha, Hye Yoon Jang, Jong Hyun Choi, Bo Won Kim, Jinhee Ahn, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Taek Jong Hong, Youngkeun Ahn, Myung Ho Jeong
We compared outcomes between biodegradable polymer biolimus-eluting stent (BP-BES) and new-generation durable polymer drug-eluting stent (DP-DES) implantations in patients with acute myocardial infarction (MI). Among 13472 patients with acute MI in a nationwide registry, 557 (64.8%) were in the BP-BES and 303 (35.2%) in the new-generation DP-DES group following coronary reperfusion. The occurrence of major adverse cardiac events (MACE; death, MI, revascularization) and stent thrombosis was compared. Major adverse cardiac events occurred in 53 (6...
November 20, 2016: Angiology
https://www.readbyqxmd.com/read/27866136/biodegradable-polymer-based-argatroban-eluting-cobalt-chromium-stent-jf-04-for-treatment-of-native-coronary-lesions-final-results-of-the-first-in-man-study-and-lessons-learned
#4
Yoshihiro Morino, Tetsuya Tobaru, Satoshi Yasuda, Kazuaki Kataoka, Kengo Tanabe, Atsushi Hirohata, Ken Kozuma, Takeshi Kimura
AIMS: The aim of the study was to investigate the six-month angiographic and nine-month clinical follow-up outcomes in a first-in-man study using the biodegradable polymer-based cobalt-chromium argatroban-eluting stent (JF-04) for treatment of native coronary atherosclerotic lesions. METHODS AND RESULTS: A total of 31 patients with either stable or unstable angina, or silent myocardial ischaemia, exhibiting de novo coronary lesions were enrolled at seven Japanese sites...
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27863648/biodegradable-airway-stents-in-infants-potential-life-threatening-pitfalls
#5
B Sztanó, G Kiss, K Márai, G Rácz, I Szegesdi, K Rácz, G Katona, L Rovó
OBJECTIVE: The solution of severe tracheobronchial obstructions in early childhood means a great challenge. Biodegradable stents were intended to be a minimally invasive temporary solution which may decrease the number of interventions and limit the possible complications of stenting procedures. However, our first experiences have brought out a new, - especially in childhood - potentially life-threatening complication of this concept. METHODS: Five SX-ELLA biodegradable polydioxanone stents was applied in three patients because of severe tracheobronchial obstruction: congenital tracheomalacia (7 day-old), acquired tracheomalacia (10 month-old), and congenital trachea-bronchomalacia (10 month-old)...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27849855/213-neointimal-coverage-patterns-in-biodegradable-vascular-scaffold-and-drug-eluting-stents
#6
Pradyumna Agasthi, Sivakanth Aloor, Aneese Chaudhry, Kwan Lee, Gautam Kumar, Rajesh Sachdeva
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27814621/drug-release-kinetics-from-a-drug-eluting-stent-with-asymmetrical-coat
#7
Haijun Zhang, Xiaodong Li, Wei Deng, Xiangfei Wang, Shenguo Wang, Junbo Ge, Egon Toft
The aim of this study was to investigate the drug release profiles of biodegradable polymer sirolimus- or paclitaxel-eluting stents with asymmetrical coating (BPSES-A or BPPES-A) both in vitro and in vivo. In vitro, the drug release profile was characterized by measuring the drug concentration by HPLC over a time-course. In vivo, a porcine aorta stenting model was employed. The results showed that the drug release rates of BPSES-A and BPPES-A were slower, more stable and less burst releasing than those of conventionally coated stents (BPSES-C and BPPES-C respectively), both in vitro and in vivo...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27806902/very-thin-strut-biodegradable-polymer-everolimus-eluting-and-sirolimus-eluting-stents-versus-durable-polymer-zotarolimus-eluting-stents-in-allcomers-with-coronary-artery-disease-bio-resort-a-three-arm-randomised-non-inferiority-trial
#8
Clemens von Birgelen, Marlies M Kok, Liefke C van der Heijden, Peter W Danse, Carl E Schotborgh, Martijn Scholte, R Melvyn Tjon Joe Gin, Samer Somi, K G van Houwelingen, M G Stoel, Frits H A F de Man, J Hans W Louwerenburg, Marc Hartmann, Paolo Zocca, Gerard C M Linssen, Job van der Palen, Carine J M Doggen, Marije M Löwik
BACKGROUND: In patients with coronary artery disease, treated with durable polymer-coated drug-eluting stents, the life-long presence of the polymer might delay arterial healing. Novel very thin strut biodegradable polymer stents, which leave only a bare metal stent after polymer resorption, might improve long-term outcome. We investigated in allcomers the safety and efficacy of three stents eluting either everolimus, sirolimus, or zotarolimus, often clinically used but never compared, of which the biodegradable polymer everolimus-eluting stent was never before assessed in allcomers...
November 26, 2016: Lancet
https://www.readbyqxmd.com/read/27806901/biodegradable-polymer-drug-eluting-stents-non-inferiority-waiting-for-superiority
#9
Aloke V Finn, Renu Virmani
No abstract text is available yet for this article.
October 28, 2016: Lancet
https://www.readbyqxmd.com/read/27802927/biolimus-eluting-versus-everolimus-eluting-stents-in-coronary-artery-disease-a-pooled-analysis-from-the-next-and-compare-ii-randomized-trials
#10
Georgios J Vlachojanni, Serban Puricel, Masahiro Natsuaki, Takeshi Morimoto, Pieter C Smits, Taskeshi Kimura
AIMS: This study sought to investigate the safety and efficacy of the biolimus-eluting stent with biodegradable polymer (BP-BES; Nobori, Terumo) compared to the everolimus-eluting stent with durable polymer (DP-EES; Xience V or Prime, Abbott Vascular, or Promus, Boston Scientific). METHODS AND RESULTS: The all-comers NEXT and COMPARE II clinical trials randomly assigned 5942 patients to BP-BES (N=3412) or DP-EES (N=2530). We conducted a patient level pooled analysis at 3 year follow-up with specified study endpoints definite stent thrombosis (ST), the combined safety endpoint cardiac death or target vessel myocardial infarction (TV-MI), and the efficacy endpoint target lesion revascularization (TLR)...
November 2, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27792651/comparison-of-vascular-responses-following-new-generation-biodegradable-and-durable-polymer-based-drug-eluting-stent-implantation-in-an-atherosclerotic-rabbit-iliac-artery-model
#11
Gaku Nakazawa, Sho Torii, Takeshi Ijichi, Hirofumi Nagamatsu, Yohei Ohno, Fumi Kurata, Ayako Yoshikawa, Masataka Nakano, Norihiko Shinozaki, Fuminobu Yoshimachi, Yuji Ikari
BACKGROUND: Incomplete endothelialization is the primary substrate of late stent thrombosis; however, recent reports have revealed that abnormal vascular responses are also responsible for the occurrence of late stent failure. The aim of the current study was to assess vascular response following deployment of biodegradable polymer-based Synergy (Boston Scientific) and Nobori (Terumo) drug-eluting stents and the durable polymer-based Resolute Integrity stent (Medtronic) in an atherosclerotic rabbit iliac artery model...
October 19, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27773862/possible-mechanical-causes-of-scaffold-thrombosis-insights-from-case-reports-with-intracoronary-imaging
#12
Yohei Sotomi, Pannipa Suwannasom, Patrick W Serruys, Yoshinobu Onuma
The advent of intracoronary stents greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug eluting stents (DES) is the increased risk of late and very late stent thrombosis (ST). The risk of ST after the DES implantation were anticipated to be solved with the advent of fully biodegradable scaffolds which offers the possibility of transient scaffolding of the vessel to prevent acute vessel closure and recoil while also transiently eluting an antiproliferative drug to counteract the constrictive remodeling and excessive neointimal hyperplasia...
October 25, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27773396/one-year-outcomes-of-a-biomime%C3%A2-sirolimus-eluting-coronary-stent-system-with-a-biodegradable-polymer-in-all-comers-coronary-artery-disease-patients-the-merit-3-study
#13
Rajendra Kumar Jain, Padmanabha Chakravarthi, Rajan Shetty, Padmakumar Ramchandra, Raghava Sarma Polavarapu, Gurupreet Singh Wander, Bishav Mohan, Darshan Navinchandra Banker, Aniruddha Dharmadhikari, Shyam Sundar Bansal, Neeraj Jain, Dharmesh Solanki, Jagdish Dhakaan, Ved Prakash Sharma, Padhinhare P Mohanan, Parayaru Kottayal Ashokan, Bagur Venkat Manjunath, Narendra Hiregoudar, Chandrashekar Patil, Narasimha Balakrishnan
OBJECTIVES: The aim of the merit-3 study was to determine the safety and performance of the BioMime Sirolimus-Eluting Coronary Stent System (SES) in all-comer patients with coronary artery disease (CAD) in one-year clinical follow-up period. METHODS: The meriT-3 was a multi-centre, observational, post-marketing study conducted in 1161 patients with CAD who were implanted with BioMime SES at 15 sites in India. The primary endpoint was major adverse cardiac event (MACE) at one year defined as the composite of cardiac death, myocardial infarction (MI) and target lesion revascularization (TLR)...
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27749637/biodegradable-stents-an-evolution-in-management-of-benign-intestinal-strictures
#14
Deepanshu Jain, Ejaz Mahmood, Shashideep Singhal
Benign intestine strictures secondary to postoperative narrowing or inflammatory bowel disease can be managed surgically or conservatively. Some patients may not be suitable surgical candidates and some patients may choose not to have repeat surgery. Biodegradable (BD) stents offer a prolonged dilatory effect before gradual degradation and obviates the need of a second procedure for stent removal. BD stents have high technical success rates (mean, 94.4%; median, 100%; range, 86% to 100%) but widely variable clinical success rates (range, 45% to 100%)...
October 4, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27725334/-metallic-ureteral-stents-present-and-future
#15
E Morcillo, I Fernández, M Pamplona, F M Sánchez-Margallo, F Soria
The management of ureteral obstruction of malignant origin or complicated benign obstruction continues to be a challenge for the urological community. In this sense, the use of metallic stents could be considered a useful alternative to the conventional drainage techniques, because it accomplishes the resolution of obstruction in a single procedure, without external diversions and without the adverse effects of current diversions. Another important advantage they offer is that they do not need replacement as frequently as double J catheters or nephrostomy tubes require...
October 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27725331/-biodegradable-catheters-and-urinary-stents-when
#16
F Soria, E Morcillo, A López de Alda, T Pastor, F M Sánchez-Margallo
One of the main wishes in the field of urinary catheters and stents is to arm them with biodegradable characteristics because we consider a failure of these devices the need for retrieval, the forgotten catheter syndrome as well as the adverse effects permanent devices cause after fulfilling their aim. The efforts focused in new designs, coatings and biomaterials aim to increase the biocompatibility of theses internal devices. Lately, there have been correct advances to answer the main challenges regarding biodegradable ureteral devices...
October 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27722631/nanoscale-patterning-of-biopolymers-for-functional-biosurfaces-and-controlled-drug-release
#17
Akshit Peer, Rabin Dhakal, Rana Biswas, Jaeyoun Kim
We compare the rates of drug release from nanopatterned and flat biodegradable polymer surfaces, and observe significantly lower release rates from the nanopatterned surfaces. Specifically, we nanopattern poly(l-lactic acid) (PLLA), a biodegradable polymer frequently used for fabricating drug-eluting coronary stents, through microtransfer molding and solvent casting and investigate the nanopattern's impact on the release of sirolimus, an immunosuppressant agent, coated on the PLLA surface using high performance liquid chromatography/mass spectrometry...
October 5, 2016: Nanoscale
https://www.readbyqxmd.com/read/27714601/intravascular-imaging-comparison-of-two-metallic-limus-eluting-stents-abluminally-coated-with-biodegradable-polymers-ivus-and-oct-results-of-the-destiny-trial
#18
J Ribamar Costa, Daniel Chamié, Alexandre A C Abizaid, Expedito Ribeiro, George C Meireles, Maurício Prudente, Carlos A Campos, Juliana P Castro, Ricardo Costa, Pedro A Lemos
We sought to compare, by means of IVUS and OCT imaging, the performance of a novel sirolimus-eluting drug-eluting stent (DES) with biodegradable polymer (Inspiron™) to the Biomatrix™ DES. From the DESTINY trial, a total of 70 randomized patients (2:1) were enrolled in the IVUS substudy (Inspiron™, n = 46; Biomatrix™: n = 20) while 25 patients were evaluated with OCT (Inspiron™, n = 19; Biomatrix™: n = 06) at 9-month follow-up. The main endpoints were % of neointimal tissue obstruction (IVUS) and neointimal stut coverage (OCT) at 9 months...
October 6, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27704201/technical-feasibility-and-tissue-reaction-after-silicone-covered-biodegradable-magnesium-stent-insertion-in-the-oesophagus-a-primary-study-in-vitro-and-in-vivo
#19
Yue-Qi Zhu, Laura Edmonds, Li-Ming Wei, Rei-La Zheng, Ruo-Yu Cheng, Wen-Guo Cui, Ying-Sheng Cheng
OBJECTIVES: Determine the feasibility of and tissue response to biodegradable magnesium-silicone stent insertion into the oesophagus of rabbits. METHODS: Mechanical compression-recovery and degradation behaviours of the stents were investigated in vitro. Thirty rabbits were randomly divided into a magnesium-silicone stent group (n = 15) that received stent insertion into the lower 1/3 of the oesophagus under fluoroscopic guidance and a control group (n = 15)...
October 4, 2016: European Radiology
https://www.readbyqxmd.com/read/27698548/bio-adaption-between-magnesium-alloy-stent-and-the-blood-vessel-a-review
#20
Jun Ma, Nan Zhao, Lexxus Betts, Donghui Zhu
Biodegradable magnesium (Mg) alloy stents are the most promising next generation of bio-absorbable stents. In this article, we summarized the progresses on the in vitro studies, animal testing and clinical trials of biodegradable Mg alloy stents in the past decades. These exciting findings led us to propose the importance of the concept "bio-adaption" between the Mg alloy stent and the local tissue microenvironment after implantation. The healing responses of stented blood vessel can be generally described in three overlapping phases: inflammation, granulation and remodeling...
September 2016: Journal of Materials Science & Technology
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