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https://www.readbyqxmd.com/read/29099705/coronary-disease-risk-assessment-in-asymptomatic-patients
#1
S Zeikidze
- to assess the risk of coronary disease in patients with asymptomatic ischemia. The work was based on the results of 185 patients' investigation, aged 35-55, among them 159 men and 26 women. All of them underwent selective coronarography. The patients were distributed according to the coronarography data - the first group consisted of individuals who had any coronary stenosis. The second group consisted of patients with intact coronaries. Statistical analysis was performed using the program packet SPSS v. 22...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29097449/genetic-and-functional-profiling-of-cd16-dependent-natural-killer-activation-identifies-patients-at-higher-risk-of-cardiac-allograft-vasculopathy
#2
Pascale Paul, Christophe Picard, Emmanuelle Sampol, Luc Lyonnet, Julie Di Cristofaro, Louise Paul-Delvaux, Guillaume Lano, Corinne Nicolino Brunet, Eleonore Ravis, Frederic Collart, Francoise Dignat George, Bertrand Dussol, Florence Sabatier, Annick Mouly Bandini
Background -Cardiac transplantation is an effective therapy for end-stage heart failure. As cardiac allograft vasculopathy (CAV) is the major cause of late mortality after heart transplant (HT), there is a need to identify markers that reflect inflammatory or cytotoxic immune mechanisms contributing to its onset. Non-invasive and early stratification of patients at risk remains a challenge for adapting individualized therapy. The CD16 (Fc-gamma receptor 3A, FCGR3A) receptor was recently identified as a major determinant of antibody-mediated natural killer (NK) cell activation in HT biopsies; however, little is known about the role of CD16 in promoting allograft vasculopathy...
November 2, 2017: Circulation
https://www.readbyqxmd.com/read/29059651/-the-features-of-a-functional-state-of-the-coronary-circulation-in-women-smokers-with-non-st-elevation-acute-coronary-syndrome
#3
Тетяна М Соломенчук, Артем О Бедзай, Василь В Процько
INTRODUCTION: Acute coronary syndrome is one of the most adverse prognostic clinical forms of ischemic heart disease. In recent years, attention of researchers and cardiologists practical attract female patients due to a substantial increase in the prevalence including acute coronary syndrome, differences in the causes and features of its course. Women often diagnosed myocardial infarction without ST elevation and nonobstructive coronary heart disease associated with coronary spasm or stratification of coronary artery...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29029775/-management-of-nstemi-in-a-hospital-without-interventional-cardiology-and-without-use-of-grace-score-does-the-clinician-appreciation-match-the-grace-score-calculated-retrospectively-for-the-coronarography-delay
#4
F Bouriche, S Yvorra, A Hassan, F Paganelli, L Bonello, S Luigi, F Attia
PURPOSE: The management of non-ST segment elevation acute coronary syndromes (NSTEACS) remains an issue for mobidity, mortality, and an economic stake. The first aim of the study was to evaluate the additional value of the GRACE score for the compliance with the recommended times to coronary angiography in an hospital without interventional cardiology. We also analysed the in-hospital and 6-month mortality and the predictive factors of compliance for the coronarography delays. METHODS: Retrospective monocenter cross-sectional study including consecutive patients with chest pain suggestive of a NSTEACS during 1 year...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29022676/vitamin-d-deficiency-in-acute-coronary-syndrome-clinically-relevant-or-incidental-finding
#5
Marijana Knežević Praveček, Željka Vuković-Arar, Blaženka Miškić, Irzal Hadžibegović
OBJECTIVE: Vitamin D deficiency has been associated with cardiovascular disease. The aim of this study was to determine serum concentration of 25 hydroxyvitamin D (25(OH)D) in patients with acute coronary syndrome (ACS) and to assess the prognostic role of serum vitamin D level in ACS patients during 3-year follow up. METHODS: The study included 60 ACS patients hospitalized at cardiology department for ACS between March 2012 and October 2012, and 60 age- and sex-matched control patients without ACS...
September 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28914344/influence-of-genetic-co-factors-on-the-population-pharmacokinetic-model-for-clopidogrel-and-its-active-thiol-metabolite
#6
Dorota Danielak, Marta Karaźniewicz-Łada, Anna Komosa, Paweł Burchardt, Maciej Lesiak, Łukasz Kruszyna, Agnieszka Graczyk-Szuster, Franciszek Główka
PURPOSE: A high interindividual variability is observed in the pharmacokinetics of clopidogrel, a widely used antiplatelet drug. In the present study, a joint parent-metabolite population pharmacokinetic model was developed to adequately describe observed concentrations of clopidogrel and its active thiol metabolite (H4). METHODS: The study included 63 patients undergoing elective coronarography or percutaneous coronary intervention. The population pharmacokinetic model was developed in the NONMEM 7...
September 15, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28670989/-sudden-cardiac-death-due-to-sarcoidosis-case-report
#7
István Sejben, Zoltán Som, Gábor Cserni
Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. The authors present the case of a 44-year-old man with bradycardia. On admission, second degree Mobitz II, then third degree atrioventricular block was diagnosed...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28594802/-remote-results-of-carotid-endarterectomy-in-patients-with-type-2-diabetes-mellitus
#8
Iu I Kazakov, A P Kas'ianenko, N Iu Sokolova, A V Bakulina, A O Iakovlev
The authors comparatively analysed the remote results of carotid endarterectomy and risk factors for unfavourable outcomes in patients with and without type 2 diabetes mellitus (DM). The outcomes of carotid endarterectomy were studied in a total of 168 patients, with the follow-up terms up to 8 years. Depending on the presence or absence of DM, the patients were divided into two groups. Group One comprised 79 patients with an atherosclerotic lesion of the internal carotid artery and accompanying DM, with Group Two consisting of 89 non-diabetic patients...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28518009/aeromedical-evacuation-using-extra-corporeal-life-support-after-resuscitated-cardiac-arrest
#9
David Gerard, Hervé Raffin, Guillaume Lebreton
BACKGROUND: Extra corporeal life support (ECLS) is presently first line therapy for refractory cardiogenic shock. Mobile circulatory support teams implant ECLS or extra corporeal membrane oxygenation (ECMO) in patients in the hospital without circulatory support. These patients are then transported to specialized centers. Here we report a case of sending a mobile circulatory support team abroad, followed by air ambulance evacuation, which, to our knowledge, has never been used as part of medical assistance abroad...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28515755/common-origin-of-all-three-coronary-arteries-from-the-right-sinus-of-valsalva-first-case-study-accompanied-by-mitral-valve-prolapse-and-vein-anomaly-second-case-study-followed-by-successful-percutaneous-coronary-intervention-of-right-coronary-artery-stenosis
#10
Brygida Przywara-Chowaniec, Agata Puzio, Łukasz Czarnecki, Damian Kawecki, Jan Głowacki, Ewa Nowalany-Kozielska, Aleksandra Czarnecka
Congenital anomalies of the coronary arteries can be divided into two broad categories: those that alter myocardial perfusion and those that do not. In coronary anomalies not altering myocardial perfusion, the coronary arteries originate from the aorta, but their origins are in unusual positions. Although myocardial perfusion is normal, the angiographer may have trouble locating them. Patients with an anomalous left main coronary artery arising from the right sinus of Valsalva are presented. The diagnosis was made by coronary angiography, transesophageal echocardiography and multislice computed tomography (MSCT)...
March 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28484288/association-between-vegf-gene-polymorphisms-and-in-stent-restenosis-after-coronary-intervention-treated-with-bare-metal-stent
#11
Zsolt Bagyura, Loretta Kiss, Kristóf Hirschberg, Balázs Berta, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
Background. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. Methods. 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled...
2017: Disease Markers
https://www.readbyqxmd.com/read/28483589/takotsubo-cardiomyopathy-after-microwave-ablation-for-metastatic-liver-lesions
#12
Mostafa Afennas, Hans Bonnier, Danny Schoors
Takotsubo cardiomyopathy (TCMP) is characterized by transient and reversible left ventricular regional wall motion abnormalities triggered by acute and intense emotional or physical stress. We present a case of a 79 year old woman with a hypertensive crisis after microwave ablation (MWA) for metastatic liver lesions. Initial evaluation suggested an acute coronary syndrome with an ST segment elevation and with elevated serum troponin T. No associated chest pain or dyspnea was present. Further evaluation with ECG, echocardiography, coronarography with left ventricle angiogram and MRI was consistent with an apical ballooning syndrome...
April 29, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28355983/mesenteric-inflammatory-veno-occlusive-disease-of-the-spleen-metasynchronous-with-two-arterial-thrombotic-events-in-systemic-lupus-erythematosus
#13
D Allali, G Puppa, C Chizzolini
Vasculitides, particularly those affecting small vessels, are known to complicate systemic lupus erythematosus (SLE); however, isolated venulitis of the mesenteric bed has rarely been reported. Here we relate the case of a 46-year-old woman with SLE who presented with acute abdominal pain due to artery thrombosis and extended splenic ischemia requiring splenectomy. The histological examination revealed diffuse venulitis in the absence of arterial vasculitis consistent with the definition of mesenteric inflammatory veno-occlusive disease (MIVOD)...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28287295/-differential-diagnostic-dilemmas-after-use-of-an-out-of-date-antihypertensive-medication-case-report
#14
Péter Arányi, János Tomcsányi
Hydrochlorothiazide became one of the most commonly prescribed first-line antihypertensive medication, though its use is often complicated with serious side-effects. A 66-year-old female patient with a history of hypertension had suffered a transient loss of consciousness, and referred to our cardiology unit with an ST-segment elevation and giant negative T-waves in V1-2 ECG leads, long QT-segment and elevated serum creatine-kinase (5392 U/L) and troponin I (4,357 ng/ml) levels. Acute myocardial infarction was not proven (later coronarography revealed preserved coronary circulation), but severe hyponatraemia and hypokalaemia was detected, explaining a possible symptomatic seizure, and which could be accounted for a 25 mg daily hydrochlorothiazide antihypertensive treatment and - as a precipitating insult - a one-week history of gastroenteritis...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28056798/high-rate-of-in-stent-restenosis-after-coronary-intervention-in-carriers-of-the-mutant-mannose-binding-lectin-allele
#15
Zsolt Bagyura, Loretta Kiss, Balázs Berta, Ágnes Szilágyi, Kristóf Hirschberg, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
BACKGROUND: In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57) are known to modulate the bioavailability of the MBL protein. Our aim was to identify the association of these polymorphisms of the MBL gene in the occurrence of in-stent restenosis after coronary artery bare metal stent implantation...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27939226/effectiveness-of-a-prehospital-wireless-12-lead-electrocardiogram-and-cardiac-catheterization-laboratory-activation-for-st-elevation-myocardial-infarction
#16
Alain Tanguay, Eric Brassard, Johann Lebon, François Bégin, Denise Hébert, Jean-Michel Paradis
The aim of the study was to determine the prevalence of false-positive and inappropriate cardiac catheterization laboratory (CCL) activation in patients suspected with ST-elevation myocardial infarction (STEMI) diverted to a percutaneous coronary intervention (PCI) facility after paramedics wireless 12-lead electrocardiogram transmission to an emergency physician at an online medical control center. This retrospective study collected data from medical records of patients with suspected STEMI from 2006 to 2014...
February 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27881283/cost-effectiveness-of-introducing-point-of-care-test-for-detection-of-level-of-glycogen-phosphorylase-in-early-diagnostic-algorithm-of-acute-coronary-syndrome
#17
Slobodan M Janković, Marina Kostić
BACKGROUND: The detection of specific biomarkers in the early phase of acute coronary syndrome (ACS) is important for the early diagnosis and appropriate management of patients with ACS. OBJECTIVES: To estimate the cost-effectiveness of introducing a diagnostic point-of-care (POC) test for determining the levels of glycogen phosphorylase BB isoform (GPBB) in a standard diagnostic algorithm for the early diagnosis of ACS within the health system of the Republic of Serbia...
September 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27788594/the-prognostic-value-of-mr-proadrenomedullin-in-patients-with-acute-coronary-syndrome-complicated-by-cardiogenic-shock
#18
Karolina Supeł, Michał Kacprzak, Marzenna Zielińska
CONTEXT: Cardiogenic shock (CS) still remains one of the main causes of death in acute myocardial infarction (AMI). OBJECTIVE: The aim of this study was to evaluate the prognostic value of midregional (MR)-proadrenomedullin in AMI complicated by CS. METHODS: Forty-seven consecutive patients were included in our prospective observational study. All patients underwent coronarography and successful percutaneous coronary intervention (PCI). Plasma levels of MR-proADM were measured by a immunofluorescence method...
May 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27753819/ssa-06-4-risk-factors-and-compliance-at-hypertensives-west-siberia-residents
#19
Davyd Yakhontov
OBJECTIVE: To study the risk factors (RF) prevalence and compliance in hypertension (Ht) associated with coronary artery diseases (CAD) pts - West Siberia residents. MATERIAL AND METHOD: 151 pts with Ht grade 1-3 and stable angina 54,8 ± 0,7 years old divided in 3 groups. The 1 group included 43 Ht pts with uncomplicated angina and intact coronary arteries, the 2 group - 47 Ht pts with angina and percutaneous coronary intervention last 1-3 years, the 3 group - 61 Ht pts with myocardial infarction (MI) or stroke last 1-3 years...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642872/ssa-06-4-risk-factors-and-compliance-at-hypertensives-west-siberia-residents
#20
Davyd Yakhontov
OBJECTIVE: To study the risk factors (RF) prevalence and compliance in hypertension (Ht) associated with coronary artery diseases (CAD) pts - West Siberia residents. MATERIAL AND METHOD: 151 pts with Ht grade 1-3 and stable angina 54,8 ± 0,7 years old divided in 3 groups. The 1 group included 43 Ht pts with uncomplicated angina and intact coronary arteries, the 2 group - 47 Ht pts with angina and percutaneous coronary intervention last 1-3 years, the 3 group - 61 Ht pts with myocardial infarction (MI) or stroke last 1-3 years...
September 2016: Journal of Hypertension
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