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https://www.readbyqxmd.com/read/28428104/tumor-budding-in-intestinal-type-gastric-adenocarcinoma-is-associated-with-nodal-metastasis-and-recurrence
#1
Stephen Olsen, Jin Linda, Ryan C Fields, Yan Yan, ILKe Nalbantoglu
Gastric adenocarcinoma (GAC) is a common cause of cancer-related death worldwide. GAC can be classified as intestinal or diffuse. Intestinal type cancers are common and reported to have a better prognosis compared to diffuse cancers. Studies have shown the presence and amount of tumor budding in intestinal carcinomas of the colon and esophagus to predict nodal metastasis and recurrence. Our aim is to determine if tumor budding in intestinal type GAC correlates with prognostic features. One hundred four patients treated with primary surgical excision between 1999-2013 were identified...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28421082/insights-into-the-structure-function-and-ion-mediated-signaling-pathways-transduced-by-plant-integrin-linked-kinases
#2
Sorina C Popescu, Elizabeth K Brauer, Gizem Dimlioglu, George V Popescu
Kinases facilitate detection of extracellular signals and set in motion cellular responses for plant adaptation and survival. Some of the energy utilized for kinase signal processing is produced through the activity of ion transporters. Additionally, the synergy between cellular ions and signal transduction influences plant response to pathogens, and their growth and development. In plants, the signaling elements that connect cell wall and membrane sensors with ion homeostasis and transport-mediated processes are largely unknown...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28414468/1-3-dipolar-cycloaddition-reactions-of-low-valent-rhodium-and-iridium-complexes-with-arylnitrile-n-oxides
#3
Ilke Ugur Marion, Sesil Agopcan Cinar, Burcu Dedeoglu, Viktorya Aviyente, M Frederick Hawthorne, Peng Liu, Fang Liu, Kendall N Houk, Gonzalo Jiménez-Osés
The reactions between low-valent Rh(I) and Ir(I) metal-carbonyl complexes and arylnitrile oxides possess the electronic and structural features of 1,3-dipolar cycloadditions. Density functional theory (DFT) calculations on these reactions, involving both cyclopentadienyl and carboranyl ligands on the metal carbonyl, explain the ease of the chemical processes and the stabilities of the resulting metallaisoxazolin-5-ones. The metal-carbonyl bond has partial double bond character according to the Wiberg index calculated through NBO analysis, and so the reaction can be considered a normal 1,3-dipolar cycloadditions involving M=C bonds...
April 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28413908/molecular-mechanisms-involved-in-podocyte-emt-and-concomitant-diabetic-kidney-diseases-an-update
#4
Qidi Ying, Guanzhong Wu
Epithelial-mesenchymal transition (EMT) is a tightly regulated process by which epithelial cells lose their hallmark epithelial characteristics and gain the features of mesenchymal cells. For podocytes, expression of nephrin, podocin, P-cadherin, and ZO-1 is downregulated, the slit diaphragm (SD) will be altered, and the actin cytoskeleton will be rearranged. Diabetes, especially hyperglycemia, has been demonstrated to incite podocyte EMT through several molecular mechanisms such as TGF-β/Smad classic pathway, Wnt/β-catenin signaling pathway, Integrins/integrin-linked kinase (ILK) signaling pathway, MAPKs signaling pathway, Jagged/Notch signaling pathway, and NF-κB signaling pathway...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28396982/frequency-of-sternal-variations-in-living-individuals
#5
Rustu Turkay, Ercan Inci, Suna Ors, Mustafa Orhan Nalbant, Ilke Ali Gurses
PURPOSE: To evaluate the variations of the sternum and provide the prevalence of sternal foramen and its anatomical relationships. METHODS: In this retrospective study, 544 subjects ranging in age from 18 to 95 years were evaluated. Sternal variations, prevalence of sternal foramen and its anatomical relationships to mediastinal structures were examined with the axial, sagittal and coronal reformat images of the patients who underwent thoracic computerized tomography...
April 10, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28379666/scube1-a-promising-biomarker-in-renal-cell-cancer
#6
Ersagun Karagüzel, Ahmet Menteşe, İlke O Kazaz, Selim Demir, Asım Örem, Ali Ertan Okatan, Diler Us Altay, Serap Özer Yaman
PURPOSE: To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker of renal tumors. MATERIALS AND METHODS: 48 individuals were included in the study. The patient group (Group-1) consisted of 23 subjects diagnosed with renal tumor, and the control group (Group-2) of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected following overnight fasting...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28367125/integrin-%C3%AE-1-increases-stem-cell-survival-and-cardiac-function-after-myocardial-infarction
#7
Lili Li, Qifan Guan, Shuling Dai, Wen Wei, Yao Zhang
Bone mesenchymal stem cells (BMSCs) transplantation is a promising therapeutic approach for myocardial infarction (MI), but its application is limited by poor viability of BMSCs. In this study, we aimed to improve the survival of BMSCs by lentivirus vector mediated overexpression of integrin β1. In vitro study showed that integrin β1 overexpression could facilitate the proliferation of BMSCs under oxygen glucose deprivation condition and regulated the expression of Caspase-3, Bax, Bcl-2, FAK, and ILK in BMSCs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28339614/integrin-linked-kinase-regulates-syncytialization-of-bewo-trophoblast-cells%C3%A2
#8
Trina M Butler, Justin A Pater, Daniel J MacPhee
During placental development, mononuclear villous cytotrophoblast cells differentiate and fuse with the overlying syncytiotrophoblast. This process requires the dissolution of E-cadherin (CDH1)-containing adherens junctions in cytotrophoblast. Integrin linked kinase (ILK) can downregulate CDH1 through poly (ADP-ribose) polymerase 1 (PARP1) and Snail-1 (SNAI1) during epithelial-mesenchymal transition. ILK is known to be expressed in cytotrophoblast; thus, the role of a potential ILK-PARP1-SNAI1 pathway in aiding trophoblast syncytialization via the downregulation of CDH1 was examined...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28335372/graphene-oxide-bionanocomposite-coatings-with-high-oxygen-barrier-properties
#9
Ilke Uysal Unalan, Derya Boyacı, Masoud Ghaani, Silvia Trabattoni, Stefano Farris
In this work, we present the development of bionanocomposite coatings on poly(ethylene terephthalate) (PET) with outstanding oxygen barrier properties. Pullulan and graphene oxide (GO) were used as main polymer phase and nanobuilding block (NBB), respectively. The oxygen barrier performance was investigated at different filler volume fractions (ϕ) and as a function of different relative humidity (RH) values. Noticeably, the impermeable nature of GO was reflected under dry conditions, in which an oxygen transmission rate (OTR, mL·m(-2)·24 h(-1)) value below the detection limit of the instrument (0...
December 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28316170/-advances-in-effects-of-integrin-linked-kinase-on-cutaneous-wound-healing-and-the-relative-mechanism
#10
R X Zhou, Y Y Li, W H Lin, G Li, J E Sun, W B Zhou
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28284625/putative-vaccine-breakthrough-event-associated-with-heterotypic-rotavirus-infection-in-newborn-calves-turkey-2015
#11
Ilke Karayel, Enikő Fehér, Szilvia Marton, Nüvit Coskun, Krisztián Bányai, Feray Alkan
Group A rotaviruses (RVA) are regarded as major enteric pathogens of large ruminants, including cattle. Rotavirus vaccines administered to pregnant cows are commonly used to provide passive immunity that protects newborn calves from the clinical disease. In this study we report the detection of RVA from calves with severe diarrhea in a herd regularly vaccinated to prevent enteric infections including RVA. Diarrheic disease was observed in newborn calves aged 4-15days, with high morbidity and mortality rates, but no diarrhea was seen in adult animals...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28273460/agrin-as-a-mechanotransduction-signal-regulating-yap-through-the-hippo-pathway
#12
Sayan Chakraborty, Kizito Njah, Ajaybabu V Pobbati, Ying Bena Lim, Anandhkumar Raju, Manikandan Lakshmanan, Vinay Tergaonkar, Chwee Teck Lim, Wanjin Hong
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functional link between the ECM proteoglycan Agrin and the transcriptional co-activator YAP. Importantly, Agrin transduces matrix and cellular rigidity signals that enhance stability and mechanoactivity of YAP through the integrin-focal adhesion- and Lrp4/MuSK receptor-mediated signaling pathways...
March 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28262032/-book-reviews
#13
Ilke Crone
No abstract text is available yet for this article.
February 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28253391/association-of-upper-eyelid-ptosis-repair-and-blepharoplasty-with-headache-related-quality-of-life
#14
Ilke Bahceci Simsek
Importance: Headache can be a functional indication for ptosis repair and blepharoplasty. Objective: To evaluate the changes in headache-related quality of life in patients who underwent upper eyelid ptosis repair or blepharoplasty. Design, Setting, and Participants: A prospective cohort study was conducted among 108 patients who underwent standard upper eyelid blepharoplasty and 44 patients who underwent ptosis repair (levator resection, Müller muscle resection, or frontalis suspension) for obscuration of the superior visual field at an ophthalmology clinic's oculoplastic department from September 1, 2014, to September 1, 2015...
March 2, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28251026/publication-rates-and-inconsistencies-of-the-abstracts-presented-at-the-national-anatomy-congresses-in-2007-and-2008
#15
İlke Ali Gürses, Özcan Gayretli, Başak Gürtekin, Adnan Öztürk
BACKGROUND: Despite significant efforts made for, most abstracts presented during a meeting do not proceed and publish as a manuscript in scientific journals. AIMS: To investigate publication rates of national anatomy congresses. STUDY DESIGN: Descriptive study. METHODS: All abstracts presented at two annual meetings in 2007 and 2008 were extracted. PubMed and Google Scholar database search used for publication history...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28237777/integrin-linked-kinase-improves-functional-recovery-of-diabetic-cystopathy-and-mesenchymal-stem-cell-survival-and-engraftment-in-rats
#16
Yi Huang, Liucheng Ding, Yunpeng Shao, Zhengsen Chen, Baixin Shen, Yinchao Ma, Lijie Zhu, Zhongqing Wei
OBJECTIVES: Diabetic cystopathy (DCP), characterized by peripheral neuropathy-associated bladder dysfunction, is a common urinary complication in patients with diabetes (~80%). Bone marrow mesenchymal stem cell (BMMSC) transplantation, a new and emerging regenerative therapy, provides a curative option for DCP. However, the application of this therapy is limited by the low survival rate and engraftment of transplanted stem cells. This study was undertaken to determine whether integrin-linked kinase (ILK) overexpression would improve stem cell survival and engraftment after BMMSC transplantation...
February 22, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28236846/the-prevention-of-benign-prostatic-hyperplasia-bph
#17
W G Roper
Barry Marshall and Robin Warren were the first to show that the chronic diseases (gastric ulcer and chronic gastritis) were caused by an infection (Helicobacter pylori). The chronic disease benign prostatic hyperplasia belongs to the same ilk, except that the infection process is much more subtle and complex. The enzyme Phospholipase D (PLD) which is attached to the outer membrane of Escherichia coli (E. coli) has now been almost completely proven to be the basic cause of BPH. The evidence for this process is now extremely strong and compelling...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28228831/retinal-nerve-fibre-layer-thickness-of-migraine-patients-with-or-without-white-matter-lesions
#18
Ilke Bahceci Simsek
The aim of this study was to determine whether retinal nerve fibre layer (RNFL) thickness is correlated with cerebral white matter lesions (WML) in migraine patients. Forty migraine and 40 healthy subjects were included in this study. The difference in RNFL thickness between the control and a migraine group with WML and a migraine group without WML were investigated using analysis of variance (ANOVA). A Tukey post hoc test was conducted to determine from which group the difference originated. Lower RNFL thicknesses were observed in the migraine patient group where WML was detected using magnetic resonance imaging (MRI), compared with the control group and with the migraine group with no WML...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28207579/expansion-of-prosodic-abilities-at-the-transition-from-babble-to-words-a-comparison-between-children-with-cochlear-implants-and-normally-hearing-children
#19
Michèle Pettinato, Ilke De Clerck, Jo Verhoeven, Steven Gillis
OBJECTIVES: This longitudinal study examined the effect of emerging vocabulary production on the ability to produce the phonetic cues to prosodic prominence in babbled and lexical disyllables of infants with cochlear implants (CI) and normally hearing (NH) infants. Current research on typical language acquisition emphasizes the importance of vocabulary development for phonological and phonetic acquisition. Children with CI experience significant difficulties with the perception and production of prosody, and the role of possible top-down effects is, therefore, particularly relevant for this population...
February 15, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28197087/the-association-between-work-related-rumination-and-heart-rate-variability-a-field-study
#20
Mark Cropley, David Plans, Davide Morelli, Stefan Sütterlin, Ilke Inceoglu, Geoff Thomas, Chris Chu
The objective of this study was to examine the association between perseverative cognition in the form of work-related rumination, and heart rate variability (HRV). We tested the hypothesis that high ruminators would show lower vagally mediated HRV relative to low ruminators during their leisure time. Individuals were classified as being low (n = 17) or high ruminators (n = 19), using the affective scale on the work-related rumination measure. HRV was assessed using a wrist sensor band (Microsoft Band 2). HRV was sampled between 8 pm and 10 pm over three workday evenings (Monday to Wednesday) while individuals carried out their normal evening routines...
2017: Frontiers in Human Neuroscience
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