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https://www.readbyqxmd.com/read/27926483/the-metastasis-suppressor-cd82-kai1-inhibits-fibronectin-adhesion-induced-epithelial-to-mesenchymal-transition-in-prostate-cancer-cells-by-repressing-the-associated-integrin-signaling
#1
Jaeseob Lee, Hee-Jung Byun, Moon-Sung Lee, Young-June Jin, Dooil Jeoung, Young-Myeong Kim, Hansoo Lee
The transmembrane protein CD82/KAI1 suppresses the metastatic potential of various cancer cell types. Moreover, decrease or loss of CD82 expression is closely associated with malignancy and poor prognosis in many human cancers including prostate cancer. Despite intense scrutiny, the mechanisms underlying the metastasis-suppressing role of CD82 are still not fully understood. Here, we found that a fibronectin matrix induced mesenchymal phenotypes in human prostate cancer cells with no or low CD82 expression levels...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27917951/catalytic-conversion-of-lipophilic-substrates-by-phase-constrained-enzymes-in-the-aqueous-or-in-the-membrane-phase
#2
Marcus Cebula, Ilke Simsek Turan, Birgitta Sjödin, Madhuranayaki Thulasingam, Joseph Brock, Volodymyr Chmyrov, Jerker Widengren, Hiroshi Abe, Bengt Mannervik, Jesper Z Haeggström, Agnes Rinaldo-Matthis, Engin U Akkaya, Ralf Morgenstern
Both soluble and membrane-bound enzymes can catalyze the conversion of lipophilic substrates. The precise substrate access path, with regard to phase, has however, until now relied on conjecture from enzyme structural data only (certainly giving credible and valuable hypotheses). Alternative methods have been missing. To obtain the first experimental evidence directly determining the access paths (of lipophilic substrates) to phase constrained enzymes we here describe the application of a BODIPY-derived substrate (PS1)...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913589/integrin-linked-kinase-ilk-deletion-disrupts-oligodendrocyte-development-by-altering-cell-cycle
#3
Rashad Hussain, Wendy B Macklin
: During development, oligodendrocytes are initially specified, after which oligodendrocyte precursor cells (OPCs) migrate and proliferate before differentiating into myelinating cells. Lineage specific programming of oligodendrocytes results from sensing environmental cues through membrane-bound receptors and related intracellular signaling molecules. Integrin linked kinase (ILK) is an important protein expressed at the inner margins of the plasma membrane, which can mediate some of these signals...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27899483/integrin-linked-kinase-is-necessary-for-the-development-of-diet-induced-hepatic-insulin-resistance
#4
Ashley S Williams, Elijah Trefts, Louise Lantier, Carrie Grueter, Deanna P Bracy, Freyja D James, Ambra Pozzi, Roy Zent, David H Wasserman
The liver extracellular matrix (ECM) expands with high fat (HF) feeding. This finding led us to address whether receptors for the ECM, integrins, are key to the development of diet-induced hepatic insulin resistance. Integrin-linked kinase (ILK) is a downstream integrin signaling molecule involved in multiple hepatic processes including those related to differentiation, wound healing and metabolism. We tested the hypothesis that deletion of ILK in mice on a HF diet would disrupt the ECM-Integrin signaling axis thereby preventing the transformation into the insulin resistant liver...
November 29, 2016: Diabetes
https://www.readbyqxmd.com/read/27897443/evaluation-of-biochemical-composition-of-vitreous-of-eyes-of-diabetic-patients-using-proton-magnetic-resonance-spectroscopy
#5
Ilke Bahceci Simsek, Ozgur Artunay
PURPOSE: To investigate possible metabolic changes in vitreous of patients with diabetes mellitus with or without diabetic retinopathy using proton magnetic resonance spectroscopy. MATERIAL AND METHODS: Twenty-eight healthy control subjects (group 1), 18 patients with diabetes mellitus without diabetic retinopathy (group 2) and 18 patients with diabetic retinopathy (group 3) were included. Proton magnetic resonance spectroscopy was performed in left vitreous of all subjects; amounts of Glutamate, Choline, Lactate and Creatine values were measured...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27888145/critical-role-of-hnrnp-a1-in-activating-kras-transcription-in-pancreatic-cancer-cells-a-molecular-mechanism-involving-g4-dna
#6
REVIEW
Susanna Cogoi, Valentina Rapozzi, Sabina Cauci, Luigi E Xodo
KRAS is one of the most mutated genes in human cancer. Its crucial role in the tumourigenesis of pancreatic ductal adenocarcinoma (PDAC) has been widely demonstrated. As this deadly cancer does not sufficiently respond to conventional chemotherapies, it is important to increase our knowledge of pancreatic cancer biology, in particular how oncogenic KRAS is regulated. The promoter of KRAS contains a GA-element composed of runs of guanines that fold into a G4 structure. This unusual DNA conformation is recognized by several nuclear proteins, including MAZ and hnRNP A1...
November 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27885829/autoclave-sterilization-of-pedot-pss-electrophysiology-devices
#7
Ilke Uguz, Mehran Ganji, Adel Hama, Atsunori Tanaka, Sahika Inal, Ahmed Youssef, Roisin M Owens, Pascale P Quilichini, Antoine Ghestem, Christophe Bernard, Shadi A Dayeh, George G Malliaras
Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.
November 25, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27846920/is-prosodic-production-driven-by-lexical-development-longitudinal-evidence-from-babble-and-words
#8
Ilke DE Clerck, Michèle Pettinato, J O Verhoeven, Steven Gillis
This study investigated the relation between lexical development and the production of prosodic prominence in disyllabic babble and words. Monthly recordings from nine typically developing Belgian-Dutch-speaking infants were analyzed from the onset of babbling until a cumulative vocabulary of 200 words was reached. The differentiation between the two syllables of isolated disyllabic utterances was computed for f0, intensity, and duration measurements. Results showed that the ambient trochaic pattern emerged in babble, but became enhanced in words...
November 16, 2016: Journal of Child Language
https://www.readbyqxmd.com/read/27845255/loss-of-lateral-prefrontal-cortex-control-in-food-directed-attention-and-goal-directed-food-choice-in-obesity
#9
Lieneke K Janssen, Iris Duif, Ilke van Loon, Joost Wegman, Jeanne H M de Vries, Roshan Cools, Esther Aarts
Loss of lateral prefrontal cortex (lPFC)-mediated attentional control may explain the automatic tendency to eat in the face of food. Here, we investigate the neurocognitive mechanism underlying attentional bias to food words and its association with obesity using a food Stroop task. We tested 76 healthy human subjects with a wide body mass index (BMI) range (19-35kg/m(2)) using fMRI. As a measure of obesity we calculated individual obesity scores based on BMI, waist circumference and waist-to-hip ratio using principal component analyses...
November 11, 2016: NeuroImage
https://www.readbyqxmd.com/read/27824126/preservation-of-epithelial-progenitor-cells-from-collagenase-digested-oral-mucosa-during-ex-vivo-cultivation
#10
Yi-Jen Hsueh, Shiang-Fu Huang, Jui-Yang Lai, Shih-Chieh Ma, Hung-Chi Chen, Sung-En Wu, Tze-Kai Wang, Chi-Chin Sun, Kevin Sheng-Kai Ma, Jan-Kan Chen, Chyong-Huey Lai, David Hui-Kang Ma
To avoid xenogeneic infection, we report a novel protocol for producing animal-derived component-free oral mucosal epithelial cells (OMECs) sheet for transplantation, in which collagenase was used to replace dispase II/trypsin-EDTA for digesting oral mucosal tissue, and human platelet-derived PLTMax to replace fetal bovine serum. The resulting epithelial aggregates were expanded on de-epithelialized amniotic membranes without 3T3 feeder cells, and serum-free EpiLife was used to reduce contamination by submucosal mesenchymal cells...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27799570/prognostic-impact-of-pleural-effusion-in-acute-pulmonary-embolism
#11
Tuncay Kiris, Selçuk Yazıcı, Ali Koc, Cinar Köprülü, Zehra Ilke Akyildiz, Mustafa Karaca, Cem Nazli, Abdullah Dogan
BACKGROUND: Pulmonary embolism (PE) is a common and life-threatening condition associated with considerable morbidity and mortality. Pleural effusion occurs in about one in three cases; however, data on its prognostic value are scarce. PURPOSE: To investigate the association between pleural effusion and both 30-day and long-term mortality in patients with acute PE. MATERIAL AND METHODS: We retrospectively evaluated 463 patients diagnosed with acute PE using computed tomography pulmonary angiography (CTPA)...
October 31, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27782347/natural-product-inspired-aminoepoxybenzoquinones-kill-members-of-the-gram-negative-pathogen-salmonella-by-attenuating-cellular-stress-response
#12
Franziska A Mandl, Volker C Kirsch, Ilke Ugur, Elena Kunold, Jan Vomacka, Christian Fetzer, Sabine Schneider, Klaus Richter, Thilo M Fuchs, Iris Antes, Stephan A Sieber
Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones and explore their antibiotic activity against several pathogenic bacteria. A compound with activity against Salmonella Typhimurium was identified, and the target enzymes were unraveled by quantitative chemical proteomics. Importantly, two protein hits were linked to bacterial stress response, and corresponding assays revealed an elevated susceptibility to reactive oxygen species upon compound treatment...
November 14, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27777079/chitosan-nanoparticles-enhances-the-anti-quorum-sensing-activity-of-kaempferol
#13
Sedef Ilk, Necdet Sağlam, Mustafa Özgen, Feza Korkusuz
Quorum sensing (QS) is a cell density dependent expression of species in bacteria mediated by compounds called autoinducers (AI). Several processes responsible for successful establishment of bacterial infection are mediated by QS. Inhibition of QS is therefore being considered as a new target for antimicrobial chemotherapy. Flavonoid compounds are strong antioxidant and antimicrobial agents but their applications are limited due to their poor dissolution and bioavailability. Our objective was to investigate the effect of kaempferol loaded chitosan nanoparticles on modulating QS mediated by AI in model bioassay test systems...
October 21, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27760768/ilk-and-cytoskeletal-architecture-an-important-determinant-of-aqp2-recycling-and-subsequent-entry-into-the-exocytotic-pathway
#14
Fahmy A Mamuya, Jose Luis Cano-Peñalver, Wei U Li, Diego Rodriguez-Puyol, Manuel Rodríguez-Puyol, Dennis Brown, Sergio de Frutos, Hua Jenny Lu
Within the past decade tremendous efforts have been made to understand the mechanism behind aquaporin-2 (AQP2) water channel trafficking and recycling, in order to open a path towards effective diabetes insipidus therapeutics. A recent study has shown that Integrin-Linked Kinase (ILK) conditional-knockdown mice developed polyuria along with decreased expression of AQP2. To understand whether ILK also regulates AQP2 trafficking in kidney tubular cells, we performed in vitro analysis using LLCPK1 cells stably expressing rat AQP2 (LLC-AQP2 cells)...
October 19, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27746181/lymphoid-aggregates-remodel-lymphatic-collecting-vessels-that-serve-mesenteric-lymph-nodes-in-crohn-disease
#15
Gwendalyn J Randolph, Shashi Bala, Jean-François Rahier, Michael W Johnson, Peter L Wang, ILKe Nalbantoglu, Laurent Dubuquoy, Amélie Chau, Benjamin Pariente, Alex Kartheuser, Bernd H Zinselmeyer, Jean-Frederic Colombel
Early pathological descriptions of Crohn disease (CD) argued for a potential defect in lymph transport; however, this concept has not been thoroughly investigated. In mice, poor healing in response to infection-induced tissue damage can cause hyperpermeable lymphatic collecting vessels in mesenteric adipose tissue that impair antigen and immune cell access to mesenteric lymph nodes (LNs), which normally sustain appropriate immunity. To investigate whether analogous changes might occur in human intestinal disease, we established a three-dimensional imaging approach to characterize the lymphatic vasculature in mesenteric tissue from controls or patients with CD...
October 13, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27723133/aunp-collagen-matrix-with-localized-stiffness-for-cardiac-tissue-engineering-enhancing-the-assembly-of-intercalated-discs-by-%C3%AE-1-integrin-mediated-signaling
#16
Yi Li, Xiaoli Shi, Lei Tian, Hongyu Sun, Yujing Wu, Xia Li, Jianjun Li, Yujie Wei, Xinxiao Han, Jiao Zhang, Xiaowei Jia, Rui Bai, Limin Jing, Peng Ding, Huiliang Liu, Dong Han
A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.
October 10, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27718563/nuciferine-alleviates-renal-injury-by-inhibiting-inflammatory-responses-in-fructose-fed-rats
#17
Ming-Xing Wang, Xiao-Juan Zhao, Tian-Yu Chen, Yang-Liu Liu, Rui-Qing Jiao, Jian-Hua Zhang, Chunhua Ma, Jia-Hui Liu, Ying Pan, Ling-Dong Kong
Nuciferine is a major active component from lotus leaf. This study examined the effects of nuciferine on fructose-induced renal injury and explored its possible mechanism. Rats consumed drinking water or 10% fructose for 12 wk. Fructose-fed rats were orally treated with water, or 7, 14 or 28 mg/kg nuciferine for the last 6 wk. HK-2 cells were exposed to 5 mM fructose alone or in combination with nuciferine (2.5-40 μM) for 24 h. Nuciferine significantly attenuated fructose-induced hyperuricemia, dyslipidemia and systemic inflammation in rats...
October 10, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27708212/paxillin-and-its-role-in-the-aging-process-of-skin-cells
#18
Anna Skoczyńska, Elżbieta Budzisz, Kasjana Podgórna, Helena Rotsztejn
Morphology of senescent cells is constantly changing at the molecular level, which in turn leads to disruption of their function. It is connected with reduced ability to synthesize extracellular matrix (ECM) and leads to the dysfunction of integrin adhesion molecules and adhesion clusters. In skin, these factors cause a loss of communication between the extracellular matrix and fibroblasts. This contributes to the appearance of signs of aging. The aim of this study is to draw attention to the very important molecule such as paxillin, which is an adaptor protein with mass of 68 kDa...
October 6, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27683053/integrin-linked-kinase-regulates-cadherin-switch-in-bladder-cancer
#19
Dorota Gil, Dorota Ciołczyk-Wierzbicka, Joanna Dulińska-Litewka, Piotr Laidler
Cadherin switch is specific of epithelial-mesenchymal transition (EMT) and is closely related to tumor cell invasion. However, the molecular mechanism that promotes the phenotypic changes remains unclear and elusive. We found that integrin-linked kinase (ILK) is a key factor involved in cadherin switch. The expression and activity of ILK are elevated in a variety of cancers but its mechanisms are not exactly understood. In this report, we studied the role and mechanism of ILK in EMT of human bladder cancer...
September 28, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27668649/expression-and-activity-of-snail-transcription-factor-during-epithelial-to-mesenchymal-transition-emt-in-cancer-progression
#20
Izabela Papiewska-Pająk, Maria A Kowalska, Joanna Boncela
Inhibition of E-cadherin gene expression by transcription factor SNAIL is known to be a crucial element of Epithelial to Mesenchymal Transition; EMT. Epigenetic regulation of E-cadherin expression is regulated by SNAIL binding to E-box sequences in the CDH1 gene promoter and recruiting enzymes belonging to repressor complexes that are directly engaged in histone modifications and DNA methylation leading to the modification of chromatin structure. SNAIL involvement in cell acquisition of invasive phenotype is based on direct suppression of tight-junction and gap junction proteins...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
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