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https://www.readbyqxmd.com/read/28522687/integrin-linked-kinase-signaling-promotes-cyst-growth-and-fibrosis-in-polycystic-kidney-disease
#1
Archana Raman, Gail A Reif, Yuqiao Dai, Aditi Khanna, Xiaogang Li, Lindsay Astleford, Stephen C Parnell, James P Calvet, Darren P Wallace
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is markedly overexpressed by cyst epithelial cells. Periostin promotes cell proliferation, cyst growth, interstitial fibrosis, and the decline in renal function in PKD mice. Here, we investigated the regulation of these processes by the integrin-linked kinase (ILK), a scaffold protein that links the extracellular matrix to the actin cytoskeleton and is stimulated by periostin...
May 18, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28512715/management-of-rainwater-harvesting-and-its-impact-on-the-health-of-people-in-the-middle-east-case-study-from-yatta-town-palestine
#2
Ilke Celik, Lina M A Tamimi, Issam A Al-Khatib, Defne S Apul
Water-related diseases are a primary problem in Palestine where many residents revert to harvested rainwater as their primary water source due to water shortages within the area. From an environmental engineering perspective, it is already well known that certain situations (e.g., cross contamination) reduce drinking water quality and ultimately cause diseases in a population. In this study, we investigated the social practices and situations that may lead to lower disease occurrence. Towards this goal, we surveyed 382 residents in Yatta to collect data on the water-related diseases that they experienced and the specific situations that might affect the disease occurrences such as the residents' practices (i) for maintaining a high quality of cistern water, (ii) for maintaining the environment around the cistern, and (iii) for managing the wastewater...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28503731/a-microfluidic-ion-pump-for-in-vivo-drug-delivery
#3
Ilke Uguz, Christopher M Proctor, Vincenzo F Curto, Anna-Maria Pappa, Mary J Donahue, Magali Ferro, Róisín M Owens, Dion Khodagholy, Sahika Inal, George G Malliaras
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior...
May 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28495591/the-hla-dr-mediated-signalling-increases-the-migration-and-invasion-of-melanoma-cells-the-expression-and-lipid-raft-recruitment-of-adhesion-receptors-pd-l1-and-signal-transduction-proteins
#4
Francesca Costantini, Giovanna Barbieri
The constitutive expression of Major Histocompatibility Complex (MHC) class II molecules is restricted to professional Antigen-Presenting Cells (APCs), nevertheless almost 50% of melanomas express constitutively the MHC class II molecules. Therefore, in two MHC class II constitutive expressing melanoma cell lines we studied the signalling mediated by the HLA-DR molecules in the aim to understand the consequence of class II mediated signalling on metastatic dissemination of melanoma. In particular, we reported that the HLA-DR mediated signalling play a new role in melanoma progression, increasing the migration and invasion of melanoma cells...
May 8, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28490443/peripheral-insulin-resistance-in-ilk-depleted-mice-by-reduction-of-glut4-expression
#5
Marco Hatem-Vaquero, Mercedes Griera, Andrea Garcia-Jerez, Alicia Luengo, Julia Alvarez-Hernandez, Jose Antonio Rubio-Garcia, Laura Calleros, Diego Rodriguez-Puyol, Manuel Rodriguez-Puyol, Sergio de Frutos
The development of insulin resistance is characterized by the impairment of glucose uptake mediated by glucose transporter 4 (GLUT4). Extracellular matrix changes are induced when the metabolic dysregulation is sustained. The present work was devoted to analyze the possible link between the extracellular-to-intracellular mediator integrin linked kinase (ILK) and the peripheral tissue modification that leads to glucose homeostasis impairment. Mice with general depletion of ILK in adulthood (cKD-ILK) maintained in a chow diet exhibited increased glycaemia and insulinemia concurrently with a reduction of the expression and membranes presence of GLUT4 in the insulin-sensitive peripheral tissues compared with their wildtype littermates (WT)...
May 10, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28488569/gene-expression-in-the-liver-remnant-is-significantly-affected-by-the-size-of-partial-hepatectomy-an-experimental-rat-study
#6
Michelle Meier, Anders Riegels Knudsen, Kasper Jarlhelt Andersen, Niels Christian Bjerregaard, Uffe Birk Jensen, Frank Viborg Mortensen
<p>Background Extended hepatectomies may result in post-hepatectomy liver failure, a conditionwith a high mortality. The main purpose of the present study was to investigate and compare the gene expression profiles in rats subjected to increasing size of partial hepatectomy.</p><p>Methods 30 Wistar rats were subjected to 30%, 70%, or 90% partial hepatectomy, sham operation or no operation. 24 hours following resection liver tissue was harvested and genome wide expression analysis was performed...
May 9, 2017: Gene Expression
https://www.readbyqxmd.com/read/28485142/low-temperature-cross-linking-of-pedot-pss-films-using-divinylsulfone
#7
Daniele Mantione, Isabel Del Agua, Wandert Schaafsma, Mohammed ElMahmoudy, Ilke Uguz, Ana Sanchez-Sanchez, Haritz Sardon, Begoña Castro, George G Malliaras, David Mecerreyes
Recent interest in bioelectronics has prompted the exploration of properties of conducting polymer films at the interface with biological milieus. Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) from a commercially available source has been used as a model system for these studies. Different cross-linking schemes have been used to stabilize films of this material against delamination and redispersion, but the cost is a decrease in the electrical conductivity and/or additional heat treatment...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28457660/ilk-regulates-mscs-survival-and-angiogenesis-partially-through-akt-and-mtor-signaling-pathways
#8
Bin Zeng, Lei Liu, Shaofeng Wang, Zhiguo Dai
Mesenchymal stem cells (MSCs) exert therapeutic effects on treating acute myocardial infarction (AMI). Angiogenesis in ischemic heart can promote the supply of oxygen and nutrients to both ischemic myocardium and transplanted stem cells. Focus is then given to the evolving strategies amied at angiogenesis. ILK has been reported to be an important factor regulating apoptosis and angiogenesis. This study examined the role and mechanism of ILK in MSCs survival and angiogenesis. In hypoxic condition, upregulation of ILK expression increased the phosphorylation of Akt and mTOR, resulting in markedly enchanced MSCs survival and VEGF expression; while significantly inhibited MSCs survival and VEGF expression was detected in MSCs with ILK kinase inactivation, which was associated with a reduction of phosphorylation of Akt and mTOR...
April 28, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28428104/tumor-budding-in-intestinal-type-gastric-adenocarcinoma-is-associated-with-nodal-metastasis-and-recurrence
#9
Stephen Olsen, Jin Linda, Ryan C Fields, Yan Yan, ILKe Nalbantoglu
Gastric adenocarcinoma (GAC) is a common cause of cancer-related death worldwide. GAC can be classified as intestinal or diffuse. Intestinal type cancers are common and reported to have a better prognosis compared to diffuse cancers. Studies have shown the presence and amount of tumor budding in intestinal carcinomas of the colon and esophagus to predict nodal metastasis and recurrence. Our aim is to determine if tumor budding in intestinal type GAC correlates with prognostic features. One hundred four patients treated with primary surgical excision between 1999-2013 were identified...
April 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28421082/insights-into-the-structure-function-and-ion-mediated-signaling-pathways-transduced-by-plant-integrin-linked-kinases
#10
Sorina C Popescu, Elizabeth K Brauer, Gizem Dimlioglu, George V Popescu
Kinases facilitate detection of extracellular signals and set in motion cellular responses for plant adaptation and survival. Some of the energy utilized for kinase signal processing is produced through the activity of ion transporters. Additionally, the synergy between cellular ions and signal transduction influences plant response to pathogens, and their growth and development. In plants, the signaling elements that connect cell wall and membrane sensors with ion homeostasis and transport-mediated processes are largely unknown...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28414468/1-3-dipolar-cycloaddition-reactions-of-low-valent-rhodium-and-iridium-complexes-with-arylnitrile-n-oxides
#11
Ilke Ugur, Sesil Agopcan Cinar, Burcu Dedeoglu, Viktorya Aviyente, M Frederick Hawthorne, Peng Liu, Fang Liu, K N Houk, Gonzalo Jiménez-Osés
The reactions between low-valent Rh(I) and Ir(I) metal-carbonyl complexes and arylnitrile oxides possess the electronic and structural features of 1,3-dipolar cycloadditions. Density functional theory (DFT) calculations on these reactions, involving both cyclopentadienyl and carboranyl ligands on the metal carbonyl, explain the ease of the chemical processes and the stabilities of the resulting metallaisoxazolin-5-ones. The metal-carbonyl bond has partial double bond character according to the Wiberg index calculated through NBO analysis, and so the reaction can be considered a normal 1,3-dipolar cycloaddition involving M═C bonds...
April 27, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28413908/molecular-mechanisms-involved-in-podocyte-emt-and-concomitant-diabetic-kidney-diseases-an-update
#12
Qidi Ying, Guanzhong Wu
Epithelial-mesenchymal transition (EMT) is a tightly regulated process by which epithelial cells lose their hallmark epithelial characteristics and gain the features of mesenchymal cells. For podocytes, expression of nephrin, podocin, P-cadherin, and ZO-1 is downregulated, the slit diaphragm (SD) will be altered, and the actin cytoskeleton will be rearranged. Diabetes, especially hyperglycemia, has been demonstrated to incite podocyte EMT through several molecular mechanisms such as TGF-β/Smad classic pathway, Wnt/β-catenin signaling pathway, Integrins/integrin-linked kinase (ILK) signaling pathway, MAPKs signaling pathway, Jagged/Notch signaling pathway, and NF-κB signaling pathway...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28396982/frequency-of-sternal-variations-in-living-individuals
#13
Rustu Turkay, Ercan Inci, Suna Ors, Mustafa Orhan Nalbant, Ilke Ali Gurses
PURPOSE: To evaluate the variations of the sternum and provide the prevalence of sternal foramen and its anatomical relationships. METHODS: In this retrospective study, 544 subjects ranging in age from 18 to 95 years were evaluated. Sternal variations, prevalence of sternal foramen and its anatomical relationships to mediastinal structures were examined with the axial, sagittal and coronal reformat images of the patients who underwent thoracic computerized tomography...
April 10, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28379666/scube1-a-promising-biomarker-in-renal-cell-cancer
#14
Ersagun Karagüzel, Ahmet Menteşe, İlke O Kazaz, Selim Demir, Asım Örem, Ali Ertan Okatan, Diler Us Altay, Serap Özer Yaman
PURPOSE: To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker of renal tumors. MATERIALS AND METHODS: 48 individuals were included in the study. The patient group (Group-1) consisted of 23 subjects diagnosed with renal tumor, and the control group (Group-2) of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected following overnight fasting...
April 6, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28367125/integrin-%C3%AE-1-increases-stem-cell-survival-and-cardiac-function-after-myocardial-infarction
#15
Lili Li, Qifan Guan, Shuling Dai, Wen Wei, Yao Zhang
Bone mesenchymal stem cells (BMSCs) transplantation is a promising therapeutic approach for myocardial infarction (MI), but its application is limited by poor viability of BMSCs. In this study, we aimed to improve the survival of BMSCs by lentivirus vector mediated overexpression of integrin β1. In vitro study showed that integrin β1 overexpression could facilitate the proliferation of BMSCs under oxygen glucose deprivation condition and regulated the expression of Caspase-3, Bax, Bcl-2, FAK, and ILK in BMSCs...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28339614/integrin-linked-kinase-regulates-syncytialization-of-bewo-trophoblast-cells%C3%A2
#16
Trina M Butler, Justin A Pater, Daniel J MacPhee
During placental development, mononuclear villous cytotrophoblast cells differentiate and fuse with the overlying syncytiotrophoblast. This process requires the dissolution of E-cadherin (CDH1)-containing adherens junctions in cytotrophoblast. Integrin linked kinase (ILK) can downregulate CDH1 through poly (ADP-ribose) polymerase 1 (PARP1) and Snail-1 (SNAI1) during epithelial-mesenchymal transition. ILK is known to be expressed in cytotrophoblast; thus, the role of a potential ILK-PARP1-SNAI1 pathway in aiding trophoblast syncytialization via the downregulation of CDH1 was examined...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28335372/graphene-oxide-bionanocomposite-coatings-with-high-oxygen-barrier-properties
#17
Ilke Uysal Unalan, Derya Boyacı, Masoud Ghaani, Silvia Trabattoni, Stefano Farris
In this work, we present the development of bionanocomposite coatings on poly(ethylene terephthalate) (PET) with outstanding oxygen barrier properties. Pullulan and graphene oxide (GO) were used as main polymer phase and nanobuilding block (NBB), respectively. The oxygen barrier performance was investigated at different filler volume fractions (ϕ) and as a function of different relative humidity (RH) values. Noticeably, the impermeable nature of GO was reflected under dry conditions, in which an oxygen transmission rate (OTR, mL·m(-2)·24 h(-1)) value below the detection limit of the instrument (0...
December 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28316170/-advances-in-effects-of-integrin-linked-kinase-on-cutaneous-wound-healing-and-the-relative-mechanism
#18
R X Zhou, Y Y Li, W H Lin, G Li, J E Sun, W B Zhou
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28284625/putative-vaccine-breakthrough-event-associated-with-heterotypic-rotavirus-infection-in-newborn-calves-turkey-2015
#19
Ilke Karayel, Enikő Fehér, Szilvia Marton, Nüvit Coskun, Krisztián Bányai, Feray Alkan
Group A rotaviruses (RVA) are regarded as major enteric pathogens of large ruminants, including cattle. Rotavirus vaccines administered to pregnant cows are commonly used to provide passive immunity that protects newborn calves from the clinical disease. In this study we report the detection of RVA from calves with severe diarrhea in a herd regularly vaccinated to prevent enteric infections including RVA. Diarrheic disease was observed in newborn calves aged 4-15days, with high morbidity and mortality rates, but no diarrhea was seen in adult animals...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28273460/agrin-as-a-mechanotransduction-signal-regulating-yap-through-the-hippo-pathway
#20
Sayan Chakraborty, Kizito Njah, Ajaybabu V Pobbati, Ying Bena Lim, Anandhkumar Raju, Manikandan Lakshmanan, Vinay Tergaonkar, Chwee Teck Lim, Wanjin Hong
The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functional link between the ECM proteoglycan Agrin and the transcriptional co-activator YAP. Importantly, Agrin transduces matrix and cellular rigidity signals that enhance stability and mechanoactivity of YAP through the integrin-focal adhesion- and Lrp4/MuSK receptor-mediated signaling pathways...
March 7, 2017: Cell Reports
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