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https://www.readbyqxmd.com/read/29442299/forecasting-pharmaceutical-prices-for-economic-evaluations-when-there-is-no-market-a-review
#1
Ilke Akpinar, Philip Jacobs, Tien Dat Tran
BACKGROUND: Economic evaluation helps policy makers and healthcare payers make decisions on drug listing, coverage, and reimbursement. When economic evaluations are conducted before a product launch, the prices of the pharmaceuticals have to be forecast. OBJECTIVE: The aim of this study was to examine the methods of establishing proxy prices and their accuracies compared with actual market prices after the product launch. METHODS: We searched the literature for evaluations for drugs that were licensed in the US between 2010 and 2015...
March 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29438844/top-down-expectation-effects-of-food-labels-on-motivation
#2
Joost Wegman, Ilke van Loon, Paul A M Smeets, Roshan Cools, Esther Aarts
Labels on food packages inform our beliefs, shaping our expectations of food properties, such as its expected taste and healthiness. These beliefs can influence the processing of caloric rewards beyond objective sensory properties and have the potential to impact decision making. However, no studies, within or beyond the food domain, have assessed how written information, such as food labels, affect implicit motivation to obtain rewards, even though choices in daily life might be strongly driven by implicit motivational biases...
February 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29436600/adenovirus-mediated-p311-ameliorates-renal-fibrosis-through-inhibition-of-epithelial-mesenchymal-transition-via-tgf-%C3%AE-1-smad-ilk-pathway-in-unilateral-ureteral-obstruction-rats
#3
Fang-Hua Qi, Ping-Ping Cai, Xiang Liu, Guo-Min Si
Epithelial-mesenchymal transition (EMT) is a critical step and key factor during renal fibrosis. Preventing renal tubular EMT is important for delaying the progression of chronic kidney disease (CKD). P311, a highly conserved 8-kDa intracellular protein, has been indicated as an important factor in myofibroblast transformation and in the progression of fibrosis. However, the related studies on P311 on renal fibrosis are limited and the mechanisms of P311 in the progression of renal tubulointerstitial fibrosis remain largely unknown...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29412654/activity-of-topotecan-towards-the-dna-topoi-complex-a-theoretical-rationalization
#4
Semiha Kevser Bali, Antoine Marion, Ilke Ugur, Ayse Kumru Dikmenli, Saron Catak, Viktorya Aviyente
Topotecan (TPT) is a non-toxic anti-cancer drug characterized by a pH dependent lactone/carboxyl equilibrium. TPT acts on the covalently bonded DNA/Topoisomerase I (DNA/TopoI) complex by intercalating between two DNA bases at the active site. This turns TopoI into a DNA-damaging agent and inhibits supercoil relaxation. Although only the lactone form of the drug is active and effectively inhibits TopoI, both forms have been co-crystalized at the same location within the DNA/TopoI complex. To gain further insights into the pH dependent activity of TPT, the differences between two TPT:DNA/TopoI complexes presenting either the lactone (acidic pH) or the carboxyl (basic pH) form of TPT were studied by means of molecular dynamic simulations, QM/MM calculations, and topological analysis...
February 7, 2018: Biochemistry
https://www.readbyqxmd.com/read/29409901/ilk-induced-epithelial-mesenchymal-transition-promotes-the-invasive-phenotype-in-adenomyosis
#5
Wenjun Zhou, Zheng Peng, Chun Zhang, Shuangshen Liu, Yi Zhang
OBJECTIVE: Adenomyosis is a benign gynecological disease, characterized by the malignant biological behaviors of invasion and metastasis. ILK plays an important role in intercellular adhesion and triggers the process of EMT. In this study, we investigated the role of ILK-induced EMT in the pathogenesis of adenomyosis. METHODS: ILK and EMT markers including E-cadherin, N-cadherin and Vimentin have been detected with Immunohistochemistry(IHC), RT-PCR and Western Blot, in normal endometrium, matched eutopic and ectopic endometrium respectively...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29379038/cardiac-shock-wave-therapy-promotes-arteriogenesis-of-coronary-micrangium-and-ilk-is-involved-in-the-biomechanical-effects-by-proteomic-analysis
#6
Wenhui Yang, Yan He, Lulu Gan, Fan Zhang, Baotong Hua, Ping Yang, Juan Liu, Li Yang, Tao Guo
Cardiac Shock Wave Therapy (CSWT) improves myocardial perfusion and ameliorates cardiac remodeling after acute myocardial infarction (AMI), but the precise mechanisms remain obscure. Herein, we have applied CSWT to a rat model of AMI to demonstrate the arteriogenesis of coronary micrangium and protein expression changes in ischemic myocardium after CSWT. Four weeks after CSWT, the fraction shortening of rats was improved greatly and the cardiomyocyte apoptosis index was significantly lower than the AMI group (P < 0...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367538/breast-cancer-clinical-trial-of-chemotherapy-and-trastuzumab-potential-tool-to-identify-cardiac-modifying-variants-of-dilated-cardiomyopathy
#7
Daniel J Serie, Julia E Crook, Brian M Necela, Bianca C Axenfeld, Travis J Dockter, Gerardo Colon-Otero, Edith A Perez, E Aubrey Thompson, Nadine Norton
Doxorubicin and the ERBB2 targeted therapy, trastuzumab, are routinely used in the treatment of HER2+ breast cancer. In mouse models, doxorubicin is known to cause cardiomyopathy and conditional cardiac knock out of Erbb2 results in dilated cardiomyopathy and increased sensitivity to doxorubicin-induced cell death. In humans, these drugs also result in cardiac phenotypes, but severity and reversibility is highly variable. We examined the association of decline in left ventricular ejection fraction (LVEF) at 15,204 single nucleotide polymorphisms (SNPs) spanning 72 cardiomyopathy genes, in 800 breast cancer patients who received doxorubicin and trastuzumab...
May 4, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29329806/effect-of-different-animal-fat-and-plant-oil-additives-on-physicochemical-mechanical-antimicrobial-and-antioxidant-properties-of-chitosan-films
#8
Lalehan Akyuz, Murat Kaya, Sedef Ilk, Yavuz Selim Cakmak, Asier M Salaberria, Jalel Labidi, Bahar Akyuz Yılmaz, Idris Sargin
Practical application of chitosan-essential oil blend films is limited due to the uneconomical extraction procedure of essential oils from plants. This study aimed to produce chitosan films blended with low cost and commercially available oils and fats consumed in daily human diet (olive, corn and sunflower oils, butter and animal fats). The study also focused on how physicochemical, biological and mechanical properties of chitosan blend films were influenced by the incorporation of oils and fats with varying unsaturation degrees...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29297744/tgfb1-is-secreted-through-an-unconventional-pathway-dependent-on-the-autophagic-machinery-and-cytoskeletal-regulators
#9
Julian Nüchel, Sushmita Ghatak, Alexandra V Zuk, Anja Illerhaus, Matthias Mörgelin, Katrin Schönborn, Katrin Blumbach, Sara A Wickström, Thomas Krieg, Gerhard Sengle, Markus Plomann, Beate Eckes
TGFB1 (transforming growth factor beta 1) is a potent cytokine playing a driving role in development, fibrosis and cancer. It is synthesized as prodomain-growth factor complex that requires tethering to LTBP (latent transforming growth factor beta binding protein) for efficient secretion into the extracellular space. Upon release, this large latent complex is sequestered by anchorage to extracellular matrix (ECM) networks, from which the mature growth factor needs to be activated in order to reach its receptors and initiate signaling...
January 3, 2018: Autophagy
https://www.readbyqxmd.com/read/29279061/characteristics-of-beef-allergy-in-schoolchildren-in-turkey
#10
Zekiye İlke Kılıç Topçu, Neşe Kaklıkkaya, Ali Baki, Fazıl Orhan
BACKGROUND: The prevalence of immunoglobulin E (IgE) mediated beef allergy in childhood is unknown. We investigated the prevalence and characteristics of IgE-mediated beef allergy in urban schoolchildren. METHODS: This cross-sectional study recruited 6000 randomly selected urban schoolchildren ages 6-17 years from the city center of Giresun in the eastern Black Sea region of Turkey during 2013. Children with suspected IgE-mediated beef allergy, determined by a self-administered questionnaire, after providing written consent, were skin-prick tested with commercial beef and cow's milk solutions and prick-prick tested with raw, boiled, and fried beef...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29274868/galectin-3-mediates-tumor-cell-stroma-interactions-by-activating-pancreatic-stellate-cells-to-produce-cytokines-via-integrin-signaling
#11
Wei Zhao, Jaffer A Ajani, Guha Sushovan, N Ochi, Rosa Hwang, Margarete Hafley, Randy L Johnson, Robert S Bresalier, Craig D Logsdon, Zhiqian Zhang, Shumei Song
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by activated pancreatic stellate cells (PSCs), abundance of extracellular matrix (ECM), and production of cytokines and chemokines. Galectin 3 (GAL3), a β galactoside-specific lectin, contributes to PDAC development but its effects on the stroma and cytokine production are unclear. METHODS: The effect of recombinant human GAL3 (rGAL3) on activation of PSC, production of cytokines, and ECM proteins were determined by proliferation, invasion, cytokine array, and quantitative PCR...
December 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29250172/association-between-integrin-linked-kinase-and-hyperthermia-in-oral-squamous-cell-carcinoma
#12
Jun Zhao, Na Liu, Xinhe Hao, Lin Que, Jiyuan Liu, Xiufa Tang
The present study aimed to observe the effect of the biological functions of integrin-linked kinase (ILK) silencing combined with hyperthermia on Tca8113 cells. Lentivirus-mediated short hairpin RNA (shRNA)-targeting ILK was transfected into oral squamous cell carcinoma (OSCC) Tca8113 cells and, combined with hyperthermia, several experimental methods were used to detect their biological behavior in vitro. On the basis of in vitro experiments, Tca8113 cells were transplanted into nude mice models, and ILK-shRNA-lentivirus was injected into the nude mice transplanted tumor and combined with hyperthermia...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29241441/antibody-separation-using-lectin-modified-poly-hema-edma-hydrogel-membranes
#13
Esra Feyzioğlu Demir, Cansu Ilke Kuru, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the as-synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10...
December 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29240030/a-case-of-familial-mediterranean-fever-having-intermittent-leukopenia
#14
Ilke Beyitler, Salih Kavukcu
Familial Mediterranean fever (FMF) is a genetically inherited autoinflammatory disorder characterized by inflammatory attacks and may result in amyloidosis as a severe complication. Elevation of acute phase reactants, including leukocytosis, is seen during attack periods. Here we describe a 13-year-old female patient with a very rare clinical presentation of FMF, who would experience FMF attacks when she did not regularly take her colchicine. During these attacks she had leukopenia and neutropenia instead of leukocytosis...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29238339/comparing-the-healthy-nose-and-nasopharynx-microbiota-reveals-continuity-as-well-as-niche-specificity
#15
Ilke De Boeck, Stijn Wittouck, Sander Wuyts, Eline F M Oerlemans, Marianne F L van den Broek, Dieter Vandenheuvel, Olivier Vanderveken, Sarah Lebeer
To improve our understanding of upper respiratory tract (URT) diseases and the underlying microbial pathogenesis, a better characterization of the healthy URT microbiome is crucial. In this first large-scale study, we obtained more insight in the URT microbiome of healthy adults. Hereto, we collected paired nasal and nasopharyngeal swabs from 100 healthy participants in a citizen-science project. High-throughput 16S rRNA gene V4 amplicon sequencing was performed and samples were processed using the Divisive Amplicon Denoising Algorithm 2 (DADA2) algorithm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29225110/assessment-of-the-cerebellar-neurotoxic-effects-of-nicotine-in-prenatal-alcohol-exposure-in-rats
#16
Dwipayan Bhattacharya, Mohammed Majrashi, Sindhu Ramesh, Manoj Govindarajulu, Jenna Bloemer, Ayaka Fujihashi, Bailee-Ryan Crump, Harrison Hightower, Subhrajit Bhattacharya, Timothy Moore, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran
The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individuals quit after learning of their pregnancy. However, there are very few scientific reports on the effect of nicotine in prenatal alcohol exposure on the cerebellum of the offspring. Therefore, this study was conducted to investigate the cerebellar neurotoxic effects of nicotine in a rodent model of Fetal Alcohol Spectrum Disorder (FASD)...
December 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29225012/comparison-of-3-techniques-in-percutaneous-tracheostomy-traditional-landmark-technique-ultrasonography-guided-long-axis-approach-and-short-axis-approach-randomised-controlled-study
#17
Kupeli Ilke, Nalbant Aysenur
INTRODUCTION: The aim of this study is to compare the reliabilities of traditional landmark method, ultrasonography-guided long-axis in-plane application, and ultrasonography-guided short-axis out-of-plane application in percutaneous dilatational tracheostomy. PATIENTS AND METHODS: A total of 60 patients were divided in 3 random groups undergoing percutaneous tracheostomy by using landmark method, ultrasonography-guided out-of-plane method, and ultrasonography-guided in-plane method...
December 7, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29221183/radial-gradient-and-radial-deviation-radiomic-features-from-pre-surgical-ct-scans-are-associated-with-survival-among-lung-adenocarcinoma-patients
#18
Ilke Tunali, Olya Stringfield, Albert Guvenis, Hua Wang, Ying Liu, Yoganand Balagurunathan, Philippe Lambin, Robert J Gillies, Matthew B Schabath
The goal of this study was to extract features from radial deviation and radial gradient maps which were derived from thoracic CT scans of patients diagnosed with lung adenocarcinoma and assess whether these features are associated with overall survival. We used two independent cohorts from different institutions for training (n= 61) and test (n= 47) and focused our analyses on features that were non-redundant and highly reproducible. To reduce the number of features and covariates into a single parsimonious model, a backward elimination approach was applied...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29200486/a-minimally-invasive-technique-using-a-modified-stoppa-approach-for-periacetabular-osteotomy-a-preliminary-cadaveric-study
#19
Turgut Akgul, Osman Coskun, Murat Korkmaz, Ilke Ali Gurses, Cengiz Sen, Ozcan Gayretli
Background: Developmental hip dysplasia is diagnosed when the femoral head is not sufficiently covered by the acetabulum. Anterior and lateral cover deficiency is seen, as a result a dysplastic hip joint. Various incision modifications have been developed because of the muscle dissection and wide wound scar in Smith-Peterson incision, which was originally used in Bernese osteotomy. This study evaluates applicability of the modified Stoppa approach in the performance of Bernese periacetabular osteotomy (PAO)...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29197429/the-economic-contribution-of-industry-sponsored-pharmaceutical-clinical-trials
#20
Dat T Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs
In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry's economic contribution of these trials to the Alberta healthcare system.  Methods: We used data from two trial centers for cancer and non-cancer trials at the University of Alberta. For each trial (cancer, non-cancer), we calculated the cost of drugs provided by the sponsors using the market price, the cost of clinical services, and the cost of administrative services that they paid...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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