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https://www.readbyqxmd.com/read/28598741/toward-a-research-agenda-for-competency-based-medical-education
#1
Larry Gruppen, Jason R Frank, Jocelyn Lockyer, Shelley Ross, M Dylan Bould, Peter Harris, Farhan Bhanji, Brian D Hodges, Linda Snell, Olle Ten Cate
Competency-based medical education (CBME) is both an educational philosophy and an approach to educational design. CBME has already had a broad impact on medical schools, residency programs, and continuing professional development in health professions around the world. As the CBME movement evolves and CBME programs are implemented, a wide range of emerging research questions will warrant scholarly examination. In this paper, we describe a proposed CBME research agenda developed by the International CBME Collaborators...
June 2017: Medical Teacher
https://www.readbyqxmd.com/read/28587768/small-things-matter-implications-of-app-intracellular-domain-aicd-nuclear-signaling-in-the-progression-and-pathogenesis-of-alzheimer-s-disease
#2
REVIEW
Hassan Bukhari, Annika Glotzbach, Katharina Kolbe, Gregor Leonhardt, Christina Loosse, Thorsten Müller
Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of millions of people affected worldwide. The pathogenesis is still poorly understood and various therapeutical approaches targeting the amyloid β (Aβ) peptide, a product of the amyloidogenic cleavage of the amyloid precursor protein (APP), failed. Moreover, a couple of studies critically questioned the relevance of Aβ in the pathogenesis of AD. Thus, new ideas need to be studied and one highly interesting hypothesis is the APP mediated signal transduction to the nucleus...
June 3, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28420743/cancer-cell-metabolism-the-essential-role-of-the-nonessential-amino-acid-glutamine
#3
REVIEW
Ji Zhang, Natalya N Pavlova, Craig B Thompson
Biochemistry textbooks and cell culture experiments seem to be telling us two different things about the significance of external glutamine supply for mammalian cell growth and proliferation. Despite the fact that glutamine is a nonessential amino acid that can be synthesized by cells from glucose-derived carbons and amino acid-derived ammonia, most mammalian cells in tissue culture cannot proliferate or even survive in an environment that does not contain millimolar levels of glutamine. Not only are the levels of glutamine in standard tissue culture media at least ten-fold higher than other amino acids, but glutamine is also the most abundant amino acid in the human bloodstream, where it is assiduously maintained at approximately 0...
May 15, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28346243/modeling-flowsheet-data-to-support-secondary-use
#4
Bonnie L Westra, Beverly Christie, Steven G Johnson, Lisiane Pruinelli, Anne LaFlamme, Suzan G Sherman, Jung In Park, Connie W Delaney, Grace Gao, Stuart Speedie
The purpose of this study was to create information models from flowsheet data using a data-driven consensus-based method. Electronic health records contain a large volume of data about patient assessments and interventions captured in flowsheets that measure the same "thing," but the names of these observations often differ, according to who performs documentation or the location of the service (eg, pulse rate in an intensive care, the emergency department, or a surgical unit documented by a nurse or therapist or captured by automated monitoring)...
March 24, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28338407/optimizing-a-retention-strategy-with-young-people-for-brightlight-a-longitudinal-cohort-study-examining-the-value-of-specialist-cancer-care-for-young-people
#5
Rachel M Taylor, Natasha Aslam, Sarah Lea, Jeremy S Whelan, Lorna A Fern
PURPOSE: To maximize retention of participants in a longitudinal cohort study, we sought to understand young peoples' views about barriers and facilitators to continuing study participation. METHODS: Ten young people with a previous cancer diagnosis aged 15-24 participated in a 1 day workshop. The workshop used participatory methodology consisting of three exercises as follows: role play/scene setting; force field analysis of research participation in small groups; and focus group discussion...
March 24, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28335868/ten-things-transgender-and-gender-nonconforming-youth-want-their-doctors-to-know
#6
EDITORIAL
Jack Turban, Tony Ferraiolo, Andrés Martin, Christy Olezeski
No abstract text is available yet for this article.
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28166745/unpredictability-dictates-quality-of-maternal-and-newborn-care-provision-in-rural-tanzania-a-qualitative-study-of-health-workers-perspectives
#7
Ulrika Baker, Farida Hassan, Claudia Hanson, Fatuma Manzi, Tanya Marchant, Stefan Swartling Peterson, Ingrid Hylander
BACKGROUND: Health workers are the key to realising the potential of improved quality of care for mothers and newborns in the weak health systems of Sub Saharan Africa. Their perspectives are fundamental to understand the effectiveness of existing improvement programs and to identify ways to strengthen future initiatives. The objective of this study was therefore to examine health worker perspectives of the conditions for maternal and newborn care provision and their perceptions of what constitutes good quality of care in rural Tanzanian health facilities...
February 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28095013/the-tipping-point-of-perceived-change-asymmetric-thresholds-in-diagnosing-improvement-versus-decline
#8
Ed O'Brien, Nadav Klein
Change often emerges from a series of small doses. For example, a person may conclude that a happy relationship has eroded not from 1 obvious fight but from smaller unhappy signs that at some point "add up." Everyday fluctuations therefore create ambiguity about when they reflect substantive shifts versus mere noise. Ten studies reveal an asymmetry in this first point when people conclude "official" change: people demand less evidence to diagnose lasting decline than lasting improvement, despite similar evidential quality...
February 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28093750/what-is-a-jungian-analyst-dreaming-when-myth-comes-to-mind-thirdness-as-an-aspect-of-the-anima-media-natura
#9
August J Cwik
Listening analytically is not listening just to what is said but listening to what is just below the surface waiting to be said. This paper looks at Jung's insight into a 'third thing' being created intra-psychically and within the analytic encounter. Ogden's concept of an 'analytic third' is used to describe the clinical aspects of this thirdness. This paper explores: how the state of thirdness is created and accessed through use of reverie and associative dreaming; how the material emerging from it is used in a from or about manner; and the eventual fate of the third in a successful analysis by a reexamination of plates four and ten of the Rosarium...
February 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/27899568/assembly-of-supramolecular-dna-complexes-containing-both-g-quadruplexes-and-i-motifs-by-enhancing-the-g-repeat-bearing-capacity-of-i-motifs
#10
Yanwei Cao, Shang Gao, Yuting Yan, Michael F Bruist, Bing Wang, Xinhua Guo
The single-step assembly of supramolecular complexes containing both i-motifs and G-quadruplexes (G4s) is demonstrated. This can be achieved because the formation of four-stranded i-motifs appears to be little affected by certain terminal residues: a five-cytosine tetrameric i-motif can bear ten-base flanking residues. However, things become complex when different lengths of guanine-repeats are added at the 3' or 5' ends of the cytosine-repeats. Here, a series of oligomers d(XGiXC5X) and d(XC5XGiX) (X = A, T or none; i < 5) are designed to study the impact of G-repeats on the formation of tetrameric i-motifs...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27867805/isolation-of-lactic-acid-bacteria-bound-to-the-porcine-intestinal-mucosa-and-an-analysis-of-their-moonlighting-adhesins
#11
Hideki Kinoshita, Satoko Ohuchi, Kensuke Arakawa, Masamichi Watanabe, Haruki Kitazawa, Tadao Saito
The adhesion of lactic acid bacteria (LAB) to the intestinal mucosa is one of the criteria in selecting for probiotics. Eighteen LAB were isolated from porcine intestinal mucin (PIM): ten strains of Lactobacillus, six strains of Weissella, and two strains of Streptococcus. Using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) for phosphate-buffered saline (PBS) extracts from the LAB, many bands were detected in half of the samples, while a few and/or no clear bands were detected in the other half...
2016: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/27786565/the-electromagnetic-basis-of-social-interactions
#12
A R Liboff
It has been established that living things are sensitive to extremely low-frequency magnetic fields at vanishingly small intensities, on the order of tens of nT. We hypothesize, as a consequence of this sensitivity, that some fraction of an individual's central nervous system activity can be magnetically detected by nearby individuals. Even if we restrict the information content of such processes to merely simple magnetic cues that are unconsciously received by individuals undergoing close-knit continuing exposure to these cues, it is likely that they will tend to associate these cues with the transmitting individual, no less than would occur if such signals were visual or auditory...
2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27561277/the-global-anticoagulant-registry-in-the-field-atrial-fibrillation%C3%A2-garfield-af-exploring-the-changes-in-anticoagulant-practice-in-patients-with-non-valvular-atrial-fibrillation-in-the-netherlands
#13
V Ten Cate, H Ten Cate, F W A Verheugt
There are over 385,000 cases of atrial fibrillation (AF) in the Netherlands, with over 45,000 new cases each year. Among other things, AF patients are at high risk of stroke. Patients are often prescribed oral anticoagulation, such as vitamin K antagonists (VKA), to mitigate these risks. A recently introduced class of oral anticoagulants, non-vitamin K antagonists (NOAC), is quickly gaining currency in global clinical practice. This study provides insight into the changes these new drugs will bring about in Dutch clinical practice...
October 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27492269/ten-things-to-know-about-critically-ill-elderly-patients
#14
Guillaume Leblanc, Ariane Boumendil, Bertrand Guidet
No abstract text is available yet for this article.
February 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/27482159/assessment-of-risk-factors-for-diabetes-mellitus-type-2
#15
Edin Begic, Amira Arnautovic, Izet Masic
INTRODUCTION: Diabetes is a group of metabolic diseases characterized by hyperglycemia, and represents a disease of the modern age, disease of the 21st century. Prevention of this disease is listed as imperative. Aim of this article was to evaluate questionnaires on the assessment of risk factors for Diabetes Mellitus type 2. MATERIAL AND METHODS: A total of 540 questionnaires handed out randomly to citizens of Canton Sarajevo of all ages, sexes and educational levels (in January 2016) were analyzed...
June 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27249880/loneliness-at-the-top-ten-ways-medical-practice-administrators-can-manage-the-isolation-of-leadership
#16
Laura Hills
Medical practice.managers spend their days surrounded by people, so the last thing they may expect to feel is lonely. Yet for many, being the manager of a medical practice can lead to feelings of isolation from the rest of the staff, and loneliness. This article explores the many reasons that managing a medical practice can be a lonely business. It considers the risks when a practice manager's loneliness goes unchecked, both to the individual and to the practice. It suggests 10 effective and healthy strategies for preventing and managing the leadership loneliness that medical practice managers sometimes experience...
March 2016: Journal of Medical Practice Management: MPM
https://www.readbyqxmd.com/read/27233730/behind-the-headlines
#17
(no author information available yet)
Bad news is the best news as far as media coverage of forensic psychiatry is concerned. A dramatic escape, allegations of ill treatment; these are the things which make the headlines, and, it should be said, which can contribute to bringing about change behind doors that may otherwise remain firmly shut. But as forensic psychiatry lurches from one public scandal to the next, it is easy to forget that behind the gruesome stories, some nurses are striving to offer a quality service, and to get the balance right between therapy and security...
September 2, 1992: Nursing Standard
https://www.readbyqxmd.com/read/27196660/ten-things-i-wish-someone-had-told-me-when-i-became-a-health-officer
#18
Thomas R Frieden
Public health, like politics, is the art of the possible. To maximize effectiveness, public health officers in any jurisdiction should (1) get good data and ensure timely and effective dissemination; (2) prioritize and tackle more difficult initiatives first; (3) find, fight, and win winnable battles in areas where progress is possible but not ensured without focused, strategic effort; (4) support and hire great people and protect them so they can do their jobs; (5) address communicable diseases and environmental health effectively; (6) do not cede the clinical realm-public health programs depend on clinical care and on effective coordination between health care and public health; (7) learn and manage the budget cycle; (8) manage the context; (9) never surprise their boss; and (10) follow core principles...
July 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27193222/genotyping-nudt15-can-predict-the-dose-reduction-of-6-mp-for-children-with-acute-lymphoblastic-leukemia-especially-at-a-preschool-age
#19
Hisato Suzuki, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Yuni Yamaki, Chie Kobayashi, Aiko Sakai, Kazuo Imagawa, Atsushi Iwabuchi, Ai Yoshimi, Tomohei Nakao, Keisuke Kato, Masahiro Tsuchida, Nobutaka Kiyokawa, Kazutoshi Koike, Emiko Noguchi, Takashi Fukushima, Ryo Sumazaki
The pharmacokinetics among children has been altered dynamically. The difference between children and adults is caused by immaturity in things such as metabolic enzymes and transport proteins. The periods when these alterations happen vary from a few days to some years after birth. We hypothesized that the effect of gene polymorphisms associated with the dose of medicine could be influenced by age. In this study, we analyzed 51 patients with childhood acute lymphoblastic leukemia (ALL) retrospectively. We examined the associations between the polymorphism in NUDT15 and clinical data, especially the dose of 6-mercaptopurine (6-MP)...
September 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27190951/marquardt-s-facial-golden-decagon-mask-and-its-fitness-with-south-indian-facial-traits
#20
Gopi Veerala, Chandra Sekhar Gandikota, Poornima K Yadagiri, Ranjit Manne, Shubhaker Rao Juvvadi, Tamkeen Farah, Shilpa Vattipelli, Sangeetha Gumbelli
INTRODUCTION: The mathematical ratio of 1:1.618 which is famously known as golden ratio seems to appear recurrently in beautiful things in nature as well as in other things that are seen as beautiful. Dr. Marquardt developed a facial golden mask that contains and includes all of the one-dimensional and two-dimensional geometric golden elements formed from the golden ratio and he claimed that beauty is universal, beautiful faces conforms to the facial golden mask regardless of sex and race...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
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