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https://www.readbyqxmd.com/read/27899568/assembly-of-supramolecular-dna-complexes-containing-both-g-quadruplexes-and-i-motifs-by-enhancing-the-g-repeat-bearing-capacity-of-i-motifs
#1
Yanwei Cao, Shang Gao, Yuting Yan, Michael F Bruist, Bing Wang, Xinhua Guo
The single-step assembly of supramolecular complexes containing both i-motifs and G-quadruplexes (G4s) is demonstrated. This can be achieved because the formation of four-stranded i-motifs appears to be little affected by certain terminal residues: a five-cytosine tetrameric i-motif can bear ten-base flanking residues. However, things become complex when different lengths of guanine-repeats are added at the 3' or 5' ends of the cytosine-repeats. Here, a series of oligomers d(XGiXC5X) and d(XC5XGiX) (X = A, T or none; i < 5) are designed to study the impact of G-repeats on the formation of tetrameric i-motifs...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27867805/isolation-of-lactic-acid-bacteria-bound-to-the-porcine-intestinal-mucosa-and-an-analysis-of-their-moonlighting-adhesins
#2
Hideki Kinoshita, Satoko Ohuchi, Kensuke Arakawa, Masamichi Watanabe, Haruki Kitazawa, Tadao Saito
The adhesion of lactic acid bacteria (LAB) to the intestinal mucosa is one of the criteria in selecting for probiotics. Eighteen LAB were isolated from porcine intestinal mucin (PIM): ten strains of Lactobacillus, six strains of Weissella, and two strains of Streptococcus. Using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) for phosphate-buffered saline (PBS) extracts from the LAB, many bands were detected in half of the samples, while a few and/or no clear bands were detected in the other half...
2016: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/27786565/the-electromagnetic-basis-of-social-interactions
#3
A R Liboff
It has been established that living things are sensitive to extremely low-frequency magnetic fields at vanishingly small intensities, on the order of tens of nT. We hypothesize, as a consequence of this sensitivity, that some fraction of an individual's central nervous system activity can be magnetically detected by nearby individuals. Even if we restrict the information content of such processes to merely simple magnetic cues that are unconsciously received by individuals undergoing close-knit continuing exposure to these cues, it is likely that they will tend to associate these cues with the transmitting individual, no less than would occur if such signals were visual or auditory...
October 27, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27561277/the-global-anticoagulant-registry-in-the-field-atrial-fibrillation%C3%A2-garfield-af-exploring-the-changes-in-anticoagulant-practice-in-patients-with-non-valvular-atrial-fibrillation-in-the-netherlands
#4
V Ten Cate, H Ten Cate, F W A Verheugt
There are over 385,000 cases of atrial fibrillation (AF) in the Netherlands, with over 45,000 new cases each year. Among other things, AF patients are at high risk of stroke. Patients are often prescribed oral anticoagulation, such as vitamin K antagonists (VKA), to mitigate these risks. A recently introduced class of oral anticoagulants, non-vitamin K antagonists (NOAC), is quickly gaining currency in global clinical practice. This study provides insight into the changes these new drugs will bring about in Dutch clinical practice...
October 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27492269/ten-things-to-know-about-critically-ill-elderly-patients
#5
Guillaume Leblanc, Ariane Boumendil, Bertrand Guidet
No abstract text is available yet for this article.
August 4, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27482159/assessment-of-risk-factors-for-diabetes-mellitus-type-2
#6
Edin Begic, Amira Arnautovic, Izet Masic
INTRODUCTION: Diabetes is a group of metabolic diseases characterized by hyperglycemia, and represents a disease of the modern age, disease of the 21st century. Prevention of this disease is listed as imperative. Aim of this article was to evaluate questionnaires on the assessment of risk factors for Diabetes Mellitus type 2. MATERIAL AND METHODS: A total of 540 questionnaires handed out randomly to citizens of Canton Sarajevo of all ages, sexes and educational levels (in January 2016) were analyzed...
June 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/27249880/loneliness-at-the-top-ten-ways-medical-practice-administrators-can-manage-the-isolation-of-leadership
#7
Laura Hills
Medical practice.managers spend their days surrounded by people, so the last thing they may expect to feel is lonely. Yet for many, being the manager of a medical practice can lead to feelings of isolation from the rest of the staff, and loneliness. This article explores the many reasons that managing a medical practice can be a lonely business. It considers the risks when a practice manager's loneliness goes unchecked, both to the individual and to the practice. It suggests 10 effective and healthy strategies for preventing and managing the leadership loneliness that medical practice managers sometimes experience...
March 2016: Journal of Medical Practice Management: MPM
https://www.readbyqxmd.com/read/27233730/behind-the-headlines
#8
(no author information available yet)
Bad news is the best news as far as media coverage of forensic psychiatry is concerned. A dramatic escape, allegations of ill treatment; these are the things which make the headlines, and, it should be said, which can contribute to bringing about change behind doors that may otherwise remain firmly shut. But as forensic psychiatry lurches from one public scandal to the next, it is easy to forget that behind the gruesome stories, some nurses are striving to offer a quality service, and to get the balance right between therapy and security...
September 2, 1992: Nursing Standard
https://www.readbyqxmd.com/read/27196660/ten-things-i-wish-someone-had-told-me-when-i-became-a-health-officer
#9
Thomas R Frieden
Public health, like politics, is the art of the possible. To maximize effectiveness, public health officers in any jurisdiction should (1) get good data and ensure timely and effective dissemination; (2) prioritize and tackle more difficult initiatives first; (3) find, fight, and win winnable battles in areas where progress is possible but not ensured without focused, strategic effort; (4) support and hire great people and protect them so they can do their jobs; (5) address communicable diseases and environmental health effectively; (6) do not cede the clinical realm-public health programs depend on clinical care and on effective coordination between health care and public health; (7) learn and manage the budget cycle; (8) manage the context; (9) never surprise their boss; and (10) follow core principles...
July 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27193222/genotyping-nudt15-can-predict-the-dose-reduction-of-6-mp-for-children-with-acute-lymphoblastic-leukemia-especially-at-a-preschool-age
#10
Hisato Suzuki, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Yuni Yamaki, Chie Kobayashi, Aiko Sakai, Kazuo Imagawa, Atsushi Iwabuchi, Ai Yoshimi, Tomohei Nakao, Keisuke Kato, Masahiro Tsuchida, Nobutaka Kiyokawa, Kazutoshi Koike, Emiko Noguchi, Takashi Fukushima, Ryo Sumazaki
The pharmacokinetics among children has been altered dynamically. The difference between children and adults is caused by immaturity in things such as metabolic enzymes and transport proteins. The periods when these alterations happen vary from a few days to some years after birth. We hypothesized that the effect of gene polymorphisms associated with the dose of medicine could be influenced by age. In this study, we analyzed 51 patients with childhood acute lymphoblastic leukemia (ALL) retrospectively. We examined the associations between the polymorphism in NUDT15 and clinical data, especially the dose of 6-mercaptopurine (6-MP)...
September 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27190951/marquardt-s-facial-golden-decagon-mask-and-its-fitness-with-south-indian-facial-traits
#11
Gopi Veerala, Chandra Sekhar Gandikota, Poornima K Yadagiri, Ranjit Manne, Shubhaker Rao Juvvadi, Tamkeen Farah, Shilpa Vattipelli, Sangeetha Gumbelli
INTRODUCTION: The mathematical ratio of 1:1.618 which is famously known as golden ratio seems to appear recurrently in beautiful things in nature as well as in other things that are seen as beautiful. Dr. Marquardt developed a facial golden mask that contains and includes all of the one-dimensional and two-dimensional geometric golden elements formed from the golden ratio and he claimed that beauty is universal, beautiful faces conforms to the facial golden mask regardless of sex and race...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27094928/perceptions-of-clinicians-and-staff-about-the-use-of-digital-technology-in-primary-care-qualitative-interviews-prior-to-implementation-of-a-computer-facilitated-5as-intervention
#12
Anna María Nápoles, Nicole Appelle, Sara Kalkhoran, Maya Vijayaraghavan, Nicholas Alvarado, Jason Satterfield
BACKGROUND: Digital health interventions using hybrid delivery models may offer efficient alternatives to traditional behavioral counseling by addressing obstacles of time, resources, and knowledge. Using a computer-facilitated 5As (ask, advise, assess, assist, arrange) model as an example (CF5As), we aimed to identify factors from the perspectives of primary care providers and clinical staff that were likely to influence introduction of digital technology and a CF5As smoking cessation counseling intervention...
2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/26957080/ten-things-that-nurses-should-know-about-ecmo
#13
Cécile Van Kiersbilck, Elizabeth Gordon, Denise Morris
No abstract text is available yet for this article.
May 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26936461/is-sadness-blue-the-problem-of-using-figurative-language-for-emotions-on-psychological-tests
#14
Kimberly A Barchard, Kelly E Grob, Matthew J Roe
Psychological tests sometimes include figurative language like I feel blue. However, figurative language may not mean the same thing cross-culturally. Previous research found cross-cultural evidence for 14 conceptual metaphors and metonymies for emotions (e.g., sadness is blue). Our two studies asked participants (total n = 795) in the USA and India whether happiness, sadness, anger, and fear are associated with certain descriptors (blue, down, bright, etc.). Most participants in both countries endorsed ten of the 14 hypothesized associations; however, the percentage of participants endorsing an association was often far from 100 %...
March 2, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/26809581/energy-challenges-in-optical-access-and-aggregation-networks
#15
REVIEW
Daniel C Kilper, Houman Rastegarfar
Scalability is a critical issue for access and aggregation networks as they must support the growth in both the size of data capacity demands and the multiplicity of access points. The number of connected devices, the Internet of Things, is growing to the tens of billions. Prevailing communication paradigms are reaching physical limitations that make continued growth problematic. Challenges are emerging in electronic and optical systems and energy increasingly plays a central role. With the spectral efficiency of optical systems approaching the Shannon limit, increasing parallelism is required to support higher capacities...
March 6, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/26781203/entrustable-professional-activities-ten-things-radiologists-do
#16
Lori A Deitte, Leonie L Gordon, Robert D Zimmerman, Eric J Stern, Theresa C McLoud, Pedro J Diaz-Marchan, Mark E Mullins
RATIONALE AND OBJECTIVES: Learner assessment in medical education has undergone tremendous change over the past two decades. During this time frame, the concept of Entrustable Professional Activities (EPAs) was introduced to guide the faculty when making competency-based decisions on the level of supervision required by trainees. EPAs are gaining momentum in medical education as a basis for decisions related to transitioning from residency training to clinical practice. The purpose of this article is twofold: (1) define EPAs for radiology (EPA-R) and (2) illustrate radiology-specific examples of these EPAs...
March 2016: Academic Radiology
https://www.readbyqxmd.com/read/26714210/top-10-things-primary-care-physicians-should-know-about-maintenance-immunosuppression-for-transplant-recipients
#17
REVIEW
Yeong-Hau H Lien
The success of organ transplantation allows many transplant recipients to return to life similar to nontransplant patients. Their need for regular health care, including preventive medicine, has switched the majority of responsibilities for their health care from transplant specialists to primary care physicians. To take care of transplant recipients, it is critical for primary care physicians to be familiar with immunosuppressive medications, their side effects, and common complications in transplant recipients...
June 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/26710801/-ten-things-to-consider-in-critical-hemodynamic-therapy
#18
Dawei Liu
No abstract text is available yet for this article.
July 7, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26694546/when-fetal-hydronephrosis-is-suspected-antenatally-a-qualitative-study
#19
Marie Oscarsson, Tomas Gottvall, Katarina Swahnberg
BACKGROUND: The information about fetal malformation findings during the ultrasound examination often comes unexpectedly, and the women and their partners may not necessarily receive any conclusive statement on the prognosis. A finding such as fetal hydronephrosis range from being a soft markers or mild anomaly, to a serious condition associated with neonatal morbidity and mortality. The aim of this study was to explore women's reactions to the discovery of fetal hydronephrosis in the context of uncertainty regarding the prognosis...
December 22, 2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26483895/narcolepsy-and-the-sickness-impact-profile-a-general-health-status-measure
#20
Thanh G N Ton, Nathaniel F Watson, Thomas D Koepsell, William T Longstreth
OBJECTIVE: We characterized functional impact of narcolepsy on patients using a general health status measure, the Sickness Impact Profile (SIP). It has 136 items grouped into 12 categories and 2 dimensions. METHODS: We ascertained patients with physician-diagnosed narcolepsy in King County, Washington using multiple overlapping methods over four years starting July 2001. We recruited 226 patients (mean age 48 years, 65% female) who underwent in-person interviews and completed: Epworth Sleepiness Scale (ESS), Ullanlinna Narcolepsy Scale (UNS), and SIP...
March 2014: Sleep Science
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