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RA nanoparticle

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https://www.readbyqxmd.com/read/29214662/airborne-particulate-concentration-during-laser-hair-removal-a-comparison-between-cold-sapphire-with-aqueous-gel-and-cryogen-skin-cooling
#1
Edward V Ross, Gary S Chuang, Arisa E Ortiz, Scott A Davenport
BACKGROUND: High concentrations of sub-micron nanoparticles have been shown to be released during laser hair removal (LHR) procedures. These emissions pose a potential biohazard to healthcare workers that have prolonged exposure to LHR plume. OBJECTIVE: We sought to demonstrate that cold sapphire skin cooling done in contact mode might suppress plume dispersion during LHR. METHODS: A total of 11 patients were recruited for laser hair removal...
December 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29199587/liposome-based-nanomedicine-therapeutics-for-rheumatoid-arthritis
#2
Mahfoozur Rahman, Sarwar Beg, Firoz Anwar, Vikas Kumar, Ruhi Ubale, Richard T Addo, Raisuddin Ali, Sohail Akhter
Rheumatoid arthritis (RA) is a very painful severe autoimmune disease with complex pathology characterized by progressive chronic inflammation, and devastation of the synovium, cartilage, and other joint-associated structures. Significant advances in research in the area of pathophysiology, diagnosis, drug development, and targeted delivery have led to improved RA therapy and better patient compliance. Targeted drug delivery using liposomal nanomedicines significantly alleviate the challenges with conventional anti-RA medications such as off-target effects, short biological half-life, poor bioavailability, high dose-related toxicity, etc...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29138531/anti-inflammatory-strategy-for-m2-microglial-polarization-using-retinoic-acid-loaded-nanoparticles
#3
Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira
Inflammatory mechanisms triggered by microglial cells are involved in the pathophysiology of several brain disorders, hindering repair. Herein, we propose the use of retinoic acid-loaded polymeric nanoparticles (RA-NP) as a means to modulate microglia response towards an anti-inflammatory and neuroprotective phenotype (M2). RA-NP were first confirmed to be internalized by N9 microglial cells; nanoparticles did not affect cell survival at concentrations below 100 μg/mL. Then, immunocytochemical studies were performed to assess the expression of pro- and anti-inflammatory mediators...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29109776/sequential-delivery-of-cyclopeptide-ra-v-and-doxorubicin-for-combination-therapy-on-resistant-tumor-and-in-situ-monitoring-of-cytochrome-c-release
#4
Huachao Chen, Yurong Wang, Yongrong Yao, Shenglin Qiao, Hao Wang, Ninghua Tan
A programmed drug delivery system that can achieve sequential release of multiple therapeutics under different stimulus holds great promise to enhance the treatment efficacy and overcome multi-drug resistance (MDR) in tumor. Herein, multi-organelle-targeted and pH/ cytochrome c (Cyt c) dual-responsive nanoparticles were designed for combination therapy on resistant tumor. In this system (designated DGLipo NPs), doxorubicin (Dox) was intercalated into the DNA duplex containing a Cyt c aptamer, which subsequently loaded in the dendrigraftpoly-L-lysines (DGL) cores of DGLipo NPs, while cyclopeptide RA-V was doped into the pH-sensitive liposomal shells...
2017: Theranostics
https://www.readbyqxmd.com/read/29106434/nanoprodrug-of-retinoic-acid-modified-paclitaxel
#5
Zijun Zhou, Jingzhe Yan, Tingting Sun, Xin Wang, Zhigang Xie
All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29104464/selective-killing-of-melanoma-cells-with-non-thermal-atmospheric-pressure-plasma-and-p-fak-antibody-conjugated-gold-nanoparticles
#6
Byul Bo Ra Choi, Jeong Hae Choi, Jin Woo Hong, Ki Won Song, Hae June Lee, Uk Kyu Kim, Gyoo Cheon Kim
Melanomas are fast growing high-mortality tumors, and specific treatments for melanomas are needed. Melanoma cells overexpress focal adhesion kinase (FAK) compared to normal keratinocytes, and we sought to exploit this difference to create a selectively lethal therapy. We combined gold nanoparticles (GNP) with antibodies targeting phosphorylated FAK (p-FAK). These conjugates (p-FAK-GNP) entered G361 melanoma cells and bound p-FAK. Treatment with p-FAK-GNP decreased the viability of G361 cells in a time dependent manner by inducing apoptosis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29049870/dendrimers-breaking-the-paradigm-of-current-musculoskeletal-autoimmune-therapies
#7
REVIEW
Daniel B Rodrigues, Joaquim M Oliveira, Tírcia C Santos, Rui L Reis
The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents which, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom-made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory and anti-inflammatory properties...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29034758/feasibility-study-on-the-use-of-gold-nanoparticles-in-fractionated-kilovoltage-x-ray-treatment-of-melanoma
#8
So-Ra Kim, Eun-Hee Kim
PURPOSE: Despite the high radioresistance of melanoma, unresectable lesions can be subjected to radiation treatment with the use of gold nanoparticles (AuNPs) as a dose-enhancing agent preferentially loaded on these lesions. The modality of single high-dose treatment has been investigated to confirm its therapeutic efficiency for AuNP-treated melanoma cells. This study explores the feasibility of utilizing AuNPs in fractionated radiation therapy of melanoma for further therapeutic gain...
October 16, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28932117/multifunctional-folate-receptor-targeting-and-ph-responsive-nanocarriers-loaded-with-methotrexate-for-treatment-of-rheumatoid-arthritis
#9
Jinlong Zhao, Menghui Zhao, Changhui Yu, Xueyan Zhang, Jiaxin Liu, Xinwei Cheng, Robert J Lee, Fengying Sun, Lesheng Teng, Youxin Li
Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive cartilage and bone destruction. Activated macrophages that overexpress folic acid (FA) receptors play an important role in RA, due to their abundance in inflamed synovial membrane and joints. In an effort to deliver drugs to the inflamed tissues, multifunctional FA receptor-targeting and pH-responsive nanocarriers were developed. They were composed of lipids, polyethylene glycol (PEG)-poly(lactic-co-glycolic acid) (PLGA) forming a hydrophilic shell, FA around the hydrophilic shell as a targeting ligand, and poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK) and PLGA as a hydrophobic core...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28921950/highly-efficient-and-rapid-neural-differentiation-of-mouse-embryonic-stem-cells-based-on-retinoic-acid-encapsulated-porous-nanoparticle
#10
Se-Jin Park, Seongchan Kim, Sung-Yon Kim, Noo Li Jeon, Joon Myong Song, Cheolhee Won, Dal-Hee Min
An improved cell conversion strategy for neural differentiation of mouse embryonic stem (mES) cells is developed by incorporating functionalized mesoporous silica nanoparticle (MSN) as an efficient delivery carrier of retinoic acid (RA), which is a pleiotropic factor required for initiation of neural differentiation. Traditional RA-mediated neural differentiation methods required either preactivation of the cells to the differentiating state by embryoid body (EB) formation or repetitive treatment of the differentiation factor...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28853583/cisplatin-mediated-formation-of-polyampholytic-chitosan-nanoparticles-with-attenuated-viscosity-and-ph-sensitive-drug-release
#11
Ra-Hye Kang, Ji-Yeong Kwon, Yeojin Kim, Sang-Min Lee
Chitosan is a biocompatible natural polysaccharide, which has been employed as a polymeric scaffold for versatile, systemic delivery platforms and for locally injectable gels with temperature-sensitive viscosity modulation. Despite the extensive investigation on the chemical modification strategies, however, most of the chitosan-based delivery platforms have been focused on the encapsulation of hydrophobic drugs, which can be simply adsorbed on the chitosan scaffolds by hydrophobic interaction via the postparticle-formation drug-loading process...
August 30, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28836756/colloidal-mesoporous-silica-nanoparticles-as-strong-adhesives-for-hydrogels-and-biological-tissues
#12
Joo-Hyung Kim, Hodae Kim, Youngjin Choi, Doo Sung Lee, Jaeyun Kim, Gi-Ra Yi
Sub-100 nm colloidal mesoporous silica (CMS) nanoparticles are evaluated as an adhesive for hydrogels or biological tissues. Because the adhesion energy is proportional to the surface area of the nanoparticles, the CMS nanoparticles could provide a stronger adhesion between two hydrogels than the nonporous silica nanoparticles. In the case of 50 nm CMS nanoparticles with a pore diameter of 6.45 nm, the maximum adhesion energy was approximately 35.0 J/m(2) at 3.0 wt %, whereas the 10 wt % nonporous silica nanoparticle solution showed only 7...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28772960/solid-state-method-synthesis-of-sno%C3%A2-decorated-g-c%C3%A2-n%C3%A2-nanocomposites-with-enhanced-gas-sensing-property-to-ethanol
#13
Jianliang Cao, Cong Qin, Yan Wang, Huoli Zhang, Guang Sun, Zhanying Zhang
SnO₂/graphitic carbon nitride (g-C₃N₄) composites were synthesized via a facile solid-state method by using SnCl₄·5H₂O and urea as the precursor. The structure and morphology of the as-synthesized composites were characterized by the techniques of X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive spectrometer (EDS), thermogravimetry-differential thermal analysis (TG-DTA), X-ray photoelectron spectroscopy (XPS), and N₂ sorption...
May 31, 2017: Materials
https://www.readbyqxmd.com/read/28749678/photofluidic-near-field-mapping-of-electric-field-resonance-in-plasmonic-metasurface-assembled-with-gold-nanoparticles
#14
Minwoo Kim, Ji-Hyeok Huh, Joohyun Lee, Hwi Je Woo, Kwangjin Kim, Dae-Woong Jung, Gi-Ra Yi, Mun Seok Jeong, Seungwoo Lee, Young Jae Song
We present a near-field mapping of electric fields from the individual superspherical and ultrasmooth gold nanoparticles (AuNPs) and artificially assembled AuNP nanostructures by measuring the reconfiguration of an azobenzene-containing polymer(azo-polymer) film. Various configurations of AuNPs and the azo-polymer were studied with atomic force microscopy measurements and calculations. The interference was systematically studied with AuNP dimers of various gap distances and different embedding depth in the polymer film...
July 31, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28726952/porphyra-polysaccharide-derived-carbon-dots-for-non-viral-co-delivery-of-different-gene-combinations-and-neuronal-differentiation-of-ectodermal-mesenchymal-stem-cells
#15
Jiaxin Chen, Qiang Wang, Jie Zhou, Wenwen Deng, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, Ximing Xu
In this study, multifunctional fluorescent carbon dots (CDs) were synthesized using a one-pot hydrothermal carbonization reaction, with the naturally-occurring porphyra polysaccharide (PPS) serving as a single carbon source for the first time and ethylenediamine (Ed) acting as the surface passivation agent. The resulting CDs enjoyed a high quantum yield (56.3%), excitation-dependent fluorescence, small size (<10 nm), spherical shape, uniform distribution, positive surface charge, low cytotoxicity and excellent ability to condense macromolecular plasmid DNA...
August 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28702988/mesoporous-sno2-nanotubes-via-electrospinning-etching-route-highly-sensitive-and-selective-detection-of-h2s-molecule
#16
Peresi Majura Bulemo, Hee-Jin Cho, Nam-Hoon Kim, Il-Doo Kim
We report the facile synthesis of thin-walled SnO2 nanotubes (NTs) with numerous clustered pores (pore radius 6.56 nm) and high surface area (125.63 m(2)/g) via selective etching of core (SiO2) region in SiO2-SnO2 composite nanofibers (NFs), in which SnO2 phase preferentially occupies the shell while SiO2 is concentrated in the center of the composite NFs. The SiO2-etched SnO2 NTs are composed of ultrasmall crystallites (∼6 nm in size) originating from crystal growth inhibition by small SiO2 domains, which are partially segregated in the polycrystalline SnO2 shell during calcination...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28673742/blue-light-potentiates-neurogenesis-induced-by-retinoic-acid-loaded-responsive-nanoparticles
#17
Tiago Santos, Raquel Ferreira, Emanuel Quartin, Carlos Boto, Cláudia Saraiva, José Bragança, João Peça, Cecília Rodrigues, Lino Ferreira, Liliana Bernardino
Neurogenic niches constitute a powerful endogenous source of new neurons that can be used for brain repair strategies. Neuronal differentiation of these cells can be regulated by molecules such as retinoic acid (RA) or by mild levels of reactive oxygen species (ROS) that are also known to upregulate RA receptor alpha (RARα) levels. Data showed that neural stem cells from the subventricular zone (SVZ) exposed to blue light (405nm laser) transiently induced NADPH oxidase-dependent ROS, resulting in β-catenin activation and neuronal differentiation, and increased RARα levels...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28671761/uptake-of-retinoic-acid-modified-pmma-nanoparticles-in-lx-2-and-liver-tissue-by-raman-imaging-and-intravital-microscopy
#18
Turgay Yildirim, Christian Matthäus, Adrian T Press, Stephanie Schubert, Michael Bauer, Jürgen Popp, Ulrich S Schubert
A primary amino-functionalized methyl methacrylate-based statistical copolymer is covalently coupled with retinoic acid (RA) and a fluorescent dye (DY590) in order to investigate the feasibility of the RA containing polymeric nanoparticles for Raman imaging studies and to study the possible selectivity of RA for hepatic stellate cells via intravital microscopy. Cationic nanoparticles are prepared by utilizing the nanoprecipitation method using modified polymers. Raman studies show that RA functional nanoparticles can be detectable in all tested cells without any need of additional label...
October 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28571554/methotrexate-in-the-treatment-of-psoriasis-and-rheumatoid-arthritis-mechanistic-insights-current-issues-and-novel-delivery-approaches
#19
P Rajitha, Raja Biswas, M Sabitha, R Jayakumar
Our review is focused on the use of methotrexate in drug therapy of two autoimmune diseases, psoriasis and rheumatoid arthritis (RA). The article describes the pathogenesis of psoriasis and RA, the role of methotrexate in the treatment of these diseases with more focused review on the mechanism behind the clinical benefits of methotrexate therapy. Methotrexate due to its cytotoxic, anti-inflammatory and immune modulatory activities provides clinical benefits in the therapy of the selected diseases. This review also gives a panorama of the problems associated with the use of methotrexate in the selected diseases and the guidelines provided by FDA for its safe use...
May 31, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28549973/targeted-delivery-of-rosmarinic-acid-across-the-blood-brain-barrier-for-neuronal-rescue-using-polyacrylamide-chitosan-poly-lactide-co-glycolide-nanoparticles-with-surface-cross-reacting-material-197-and-apolipoprotein-e
#20
Yung-Chih Kuo, Rajendiran Rajesh
Rosmarinic acid-loaded polyacrylamide-chitosan-poly(lactide-co-glycolide) nanoparticles (RA-PAAM-CH-PLGA NPs) were grafted with cross-reacting material 197 (CRM197) and apolipoprotein E (ApoE) for targeting of the blood-brain barrier (BBB) and rescuing degenerated neurons. The polymeric nanocarriers were prepared by microemulsion, solvent diffusion, grafting, and surface modification, and CRM197-ApoE-RA-PAAM-CH-PLGA NPs were used to treat human brain-microvascular endothelial cells, RWA264.7 cells, and Aβ-insulted SK-N-MC cells...
August 7, 2017: International Journal of Pharmaceutics
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