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https://www.readbyqxmd.com/read/27895468/increased-localized-delivery-of-piroxicam-by-cationic-nanoparticles-after-intra-articular-injection
#1
Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi, Myung Joo Kang
Piroxicam (PRX), a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP) was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA) injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA) in the synovial cavity...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27755995/the-photobleaching-of-the-free-and-encapsulated-metallic-phthalocyanine-and-its-effect-on-the-photooxidation-of-simple-molecules
#2
Brenda Gomes Fanchiotti, Marcella Piffer Zamprogno Machado, Letícia Camilato de Paula, Mahmut Durmuş, Tebello Nyokong, Arlan da Silva Gonçalves, André Romero da Silva
The photobleaching of an unsubstituted phthalocyanine (gallium(III) phthalocyanine chloride (GaPc)) and a substituted phthalocyanine (1,4-(tetrakis[4-(benzyloxy)phenoxy]phthalocyaninato) indium(III) chloride (InTBPPc)) was monitored for the free photosensitizers and for the phthalocyanines encapsulated into nanoparticles of PEGylated poly(D,L-lactide-co-glycolide) (PLGA-PEG). Phosphate-buffered solutions (PBS) and organic solutions of the free GaPc or the free InTBPPc, and suspensions of each encapsulated photosensitizer (2-15μmol/L) were irradiated using a laser diode of 665nm with a power of 1-104mW and a light dose of 7...
October 11, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27736727/novel-self-assembled-tacrolimus-nanoparticles-cross-linking-thermosensitive-hydrogels-for-local-rheumatoid-arthritis-therapy
#3
Huimin Wu, Kaiyuan Wang, Hanning Wang, Fang Chen, Wencong Huang, Yuqi Chen, Jiali Chen, Jin Tao, Xiaoguang Wen, Subin Xiong
The aim was to explore the potential application of novel self-assembled nanoparticles cross-linking thermosensitive hydrogels composed of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) and tacrolimus (FK-506) for local therapy of rheumatoid arthritis (RA). The sol-gel transition temperature (Tsol-gel), gelation time, rheological behaviors, in vitro release, in vivo gelation and retention, and therapeutic efficacy against adjuvant-induced arthritis (AIA) rats were compared between the Soluplus hydrogels and widely studied poloxamer 407 (P407) delivery systems...
October 6, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27703610/silver-nanoparticles-in-resin-luting-cements-antibacterial-and-physiochemical-properties
#4
Ana-Paula-Rodrigues Magalhães, Francine-Couto-Lima Moreira, Denise-Ramos-Silveira Alves, Cyntia-Rodrigues-Araújo Estrela, Carlos Estrela, Marcus-Santos Carrião, Andris-Figueiroa Bakuzis, Lawrence-Gonzaga Lopes
BACKGROUND: Silver has a long history of use in medicine as an antimicrobial and anti-inflammatory agent. Silver nanoparticles (NAg) offer the possibility to control the formation oral biofilms through the use of nanoparticles with biocidal, anti-adhesive, and delivery abilities. This study aims to evaluate the antibacterial effect of resin luting cements with and without NAg, and their influence on color, sorption and solubility. MATERIAL AND METHODS: NAg were incorporated to two dual-cured resin cements (RelyX ARC (RA) color A1 and RelyX U200 (RU) color A2) in two concentrations (0...
October 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27689720/a-versatile-route-to-polymer-reinforced-broadband-antireflective-and-superhydrophobic-thin-films-without-high-temperature-treatment
#5
Tingting Ren, Zhi Geng, Junhui He, Xiaojie Zhang, Jin He
Broadband high transmittance, good mechanical robustness as well as simple and low temperature fabrication are three important aspects that dictate the practical applications of superhydrophobic thin films, especially on organic substrates. However, it has proved difficult to meet these challenges. In the present work, superhydrophobic thin films were prepared by first dip-coating solid silica nanoparticles, then spray-coating hollow silica nanoparticles, followed by spray-coating mesoporous silica nanosheets & poly(vinyl alcohol) (PVA), and eventually chemical vapor deposition of 1H,1H,2H,2H-perflurooctyltriethoxysilane (POTS) at 90°C...
September 24, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27663233/macrophages-mediated-diagnosis-of-rheumatoid-arthritis-using-fibrin-based-magnetic-nanoparticles-as-mri-contrast-agents
#6
Prabu Periyathambi, Thotapalli Parvathaleswara Sastry, Suresh Kumar Anandasadagopan, Kanagavel Manickavasagam
BACKGROUND: A variety of bioimaging tools assists in the diagnosis and evaluation of rheumatoid arthritis (RA) and other osteoarthritis. However, detection of RA in the early stages by targeting its macrophages with suitable contrast agents will help in arresting the progression of the disease. METHODS: In the present study, we investigated the effectiveness of using magnetic fibrin nanoparticles (MFNPs) conjugated with folic acid (FA-MFNPs) as a specific contrast agent to target the activated macrophages, which overexpress the folate receptors (FR) in the knee joints of rats with antigen-induced arthritis (AIA)...
September 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27643533/long-circulating-au-tio2-nanocomposite-as-a-sonosensitizer-for-ros-mediated-eradication-of-cancer
#7
V G Deepagan, Dong Gil You, Wooram Um, Hyewon Ko, Seunglee Kwon, Ki Young Choi, Gi-Ra Yi, Jun Young Lee, Doo Sung Lee, Kwangmeyung Kim, Ick Chan Kwon, Jae Hyung Park
Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nanocomposites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo...
October 3, 2016: Nano Letters
https://www.readbyqxmd.com/read/27617481/facile-synthesis-of-platelike-hierarchical-li1-2mn0-54ni0-13co0-13o2-with-exposed-010-planes-for-high-rate-and-long-cycling-stable-lithium-ion-batteries
#8
Jiong Zeng, Yanhui Cui, Deyang Qu, Qian Zhang, Junwei Wu, Xiaomeng Zhu, Zuohua Li, Xinhe Zhang
Lithium-rich layered oxides are promising cathode candidates for the production of high-energy and high-power electronic devices with high specific capacity and high discharge voltage. However, unstable cycling performance, especially at high charge-recharge rate, is the most challenge issue which needs to be solved to foster the diffusion of these materials. In this paper, hierarchical platelike Li1.2Mn0.54Ni0.13Co0.13O2 cathode materials were synthesized by a facile solvothermal method followed by calcination...
October 5, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27548677/virus-like-nanoparticle-vaccine-confers-protection-against-toxoplasma-gondii
#9
Dong Hun Lee, Su Hwa Lee, Ah Ra Kim, Fu Shi Quan
The inner membrane complex (IMC) of Toxoplasma gondii as a peripheral membrane system has unique and critical roles in parasite replication, motility and invasion. Disruption of IMC sub-compartment protein produces a severe defect in T. gondii endodyogeny, the form of internal cell budding. In this study, we generated T. gondii virus-like particle particles (VLPs) containing proteins derived from IMC, and investigated their efficacy as a vaccine in mice. VLP vaccination induced Toxoplasma gondii-specific total IgG, IgG1 and IgG2a antibody responses in the sera and IgA antibody responses in the feces...
2016: PloS One
https://www.readbyqxmd.com/read/27536103/safety-profile-of-solid-lipid-nanoparticles-loaded-with-rosmarinic-acid-for-oral-use-in-vitro-and-animal-approaches
#10
Ana Raquel Madureira, Sara Nunes, Débora A Campos, João C Fernandes, Cláudia Marques, Monica Zuzarte, Beatriz Gullón, Luís M Rodríguez-Alcalá, Conceição Calhau, Bruno Sarmento, Ana Maria Gomes, Maria Manuela Pintado, Flávio Reis
Rosmarinic acid (RA) possesses several protective bioactivities that have attracted increasing interest by nutraceutical/pharmaceutical industries. Considering the reduced bioavailability after oral use, effective (and safe) delivery systems are crucial to protect RA from gastrointestinal degradation. This study aims to characterize the safety profile of solid lipid nanoparticles produced with Witepsol and Carnauba waxes and loaded with RA, using in vitro and in vivo approaches, focused on genotoxicity and cytotoxicity assays, redox status markers, hematological and biochemical profile, liver and kidney function, gut bacterial microbiota, and fecal fatty acids composition...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27522484/3d-origami-electrochemical-device-for-sensitive-pb-2-testing-based-on-dna-functionalized-iron-porphyrinic-metal-organic-framework
#11
Xiu Wang, Chunlei Yang, Shaojun Zhu, Mei Yan, Shenguang Ge, Jinghua Yu
A highly sensitive electrochemical (EC) biosensor combined with a 3D origami device for detection of Pb(2+)was developed based on novel Au nanoparticles modified paper working electrode (Au-PWE) as sensor platform and DNA functionalized iron-porphyrinic metal-organic framework ((Fe-P)n-MOF-Au-GR) hybrids as signal probes. In the presence of Pb(2+), GR could be specifically cleaved at the ribonucleotide (rA) site, which produced the short (Fe-P)n-MOF-linked oligonucleotide fragment to hybridize with hairpin DNA immobilized on the surface of Au-PWE...
August 5, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27499622/proretinal-nanoparticles-stability-release-efficacy-and-irritation
#12
Pimolphan Pisetpackdeekul, Piyapan Supmuang, Porntip Pan-In, Wijit Banlunara, Benchaphorn Limcharoen, Chayada Kokpol, Supason Wanichwecharungruang
Despite many potent biological activities, retinoids such as retinoic acid (RA) and retinal possess dose-related broad side effects. In this study, we show that this problem, which has been unsolvable for a long time, can be tackled through a controlled release strategy in which retinal is continuously delivered to the skin via sustained release from proretinal nanoparticles. The water dispersible proretinal nanoparticles are stable when kept in water at neutral pH and at room temperature for 8 months under light-proof conditions, and show sustained release of retinal into human synthetic sebum at a pH of 5...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27280251/size-dependent-cellular-uptake-of-trans-activator-of-transcription-functionalized-nanoparticles
#13
Heesuk Kim, Jin-Ha Choi, So-Ra Kang, Byung-Keun Oh, Wonkoo Lee, Oh-Sun Kwon, Kwanwoo Shin
We investigated the cellular uptake efficiencies of differently-sized silica nanoparticles in the presence and the absence of trans-activator of transcription (TAT) peptide. Silica nanoparticles incorporating fluorescent dye molecules with diameters of 30 to 800 nm were synthesized, and the surfaces of the silica nanoparticles were functionalized with TAT peptides or 3-aminopropyltriethoxysilane (APTES). Confocal microscopy and flow cytometry were used to determine the cellular locations and the uptake efficiencies of positively-charged silica nanoparticles (APTES- and TAT-) of various sizes from 30 to 800 nm...
March 2016: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/27219463/complex-thermodynamic-behavior-of-single-stranded-nucleic-acid-adsorption-to-graphene-surfaces
#14
Srivathsan V Ranganathan, Ken Halvorsen, Chris A Myers, Neil M Robertson, Mehmet V Yigit, Alan A Chen
In just over a decade since its discovery, research on graphene has exploded due to a number of potential applications in electronics, materials, and medicine. In its water-soluble form of graphene oxide, the material has shown promise as a biosensor due to its preferential absorption of single-stranded polynucleotides and fluorescence quenching properties. The rational design of these biosensors, however, requires an improved understanding of the binding thermodynamics and ultimately a predictive model of sequence-specific binding...
June 21, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27191896/binding-strength-of-nucleobases-and-nucleosides-on-silver-nanoparticles-probed-by-a-colorimetric-method
#15
Lu Yu, Na Li
Because of their unique and tunable properties, oligonucleotide-functionalized noble metal nanoparticles have provided a versatile platform for various engineering and biomedical applications. The vast majority of such applications were demonstrated with gold nanoparticles (AuNPs) while only a few were demonstrated with sliver nanoparticles (AgNPs). This is largely due to the lack of robust protocols to functionalize AgNPs with thiol-modified oligonucleotides. Previous studies have revealed strong interactions between nucleobases and AgNPs...
June 7, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27189528/methylprednisolone-acetate-loaded-hydroxyapatite-nanoparticles-as-a-potential-drug-delivery-system-for-treatment-of-rheumatoid-arthritis-in-vitro-and-in-vivo-evaluations
#16
Samira Jafari, Nasrin Maleki-Dizaji, Jaleh Barar, Mohammad Barzegar-Jalali, Maryam Rameshrad, Khosro Adibkia
The objective of this study was to improve the therapeutic efficacy of methylprednisolone acetate (MPA) in the treatment of rheumatoid arthritis (RA) by incorporating the drug into the hydroxyapatite (HAp) nanoparticles. The nanoparticles were synthesized using a chemical precipitation technique and their size and morphology were evaluated by dynamic light scattering and scanning electron microscopy (SEM). The solid-state behavior of the nanoparticles was also characterized by operating X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR)...
August 25, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27133037/utilization-of-nanoparticle-technology-in-rheumatoid-arthritis-treatment
#17
REVIEW
Sanam Dolati, Sanam Sadreddini, Davoud Rostamzadeh, Majid Ahmadi, Farhad Jadidi-Niaragh, Mehdi Yousefi
Rheumatoid arthritis (RA) is one of the common and severe autoimmune diseases related to joints. This chronic autoimmune inflammatory disease, leads to functional limitation and reduced quality of life, since as there is bone and cartilage destruction, joint swelling and pain. Current advances and new treatment approaches have considerably postponed disease progression and improved the quality of life for many patients. In spite of major advances in therapeutic options, restrictions on the routes of administration and the necessity for frequent and long-term dosing often result in systemic adverse effects and patient non-compliance...
May 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27082936/-retracted-retinoic-acid%C3%A2-incorporated-glycol-chitosan-nanoparticles-inhibit-the-expression-of-ezh2-in-u118-and-u138-human-glioma-cells
#18
Hu-Chen Lu, Jun Ma, Zong Zhuang, Yao Zhang, Hui-Lin Cheng, Ji-Xin Shi
We wish to retract our research article entitled "Retinoic acid-incorporated glycol chitosan nanoparticles inhibit Ezh2 expression in U118 and U138 human glioma cells" published in Molecular Medicine Reports 12: 6642-6648, 2015. An interested reader noted some anomalies in the presentation of Fig. 4 in our paper, calling into question the validity of the reported data. In examining our original article, we acknowledge that the data for RA (25 µm) did not show a higher density of cells compared with RA (10 µm), as shown in Fig...
June 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27063494/zwitterionic-mesoporous-nanoparticles-with-a-bioresponsive-gatekeeper-for-cancer-therapy
#19
Shakera Khatoon, Hwa Seung Han, Minchang Lee, Hansang Lee, Dae-Woong Jung, Thavasyappan Thambi, M Ikram, Young Mo Kang, Gi-Ra Yi, Jae Hyung Park
UNLABELLED: To enhance cellular uptake and site-specific drug release in the tumor microenvironment, zwitterionic mesoporous silica nanoparticles (Z-MSN) were prepared by introducing a bioresponsive gatekeeper composed of negatively charged carboxylic groups and positively charged quaternary amine groups. When these Z-MSN encountered a mildly acidic environment, their surface charge readily switched from negative to positive by cleavage of an acid-labile maleic amide linkage, thus allowing for effective cellular uptake into tumor tissue...
August 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27025400/retinoic-acid-loaded-polymeric-nanoparticles-enhance-vascular-regulation-of-neural-stem-cell-survival-and-differentiation-after-ischaemia
#20
R Ferreira, M C Fonseca, T Santos, J Sargento-Freitas, R Tjeng, F Paiva, M Castelo-Branco, L S Ferreira, L Bernardino
Stroke is one of the leading causes of death and disability worldwide. However, current therapies only reach a small percentage of patients and may cause serious side effects. We propose the therapeutic use of retinoic acid-loaded nanoparticles (RA-NP) to safely and efficiently repair the ischaemic brain by creating a favourable pro-angiogenic environment that enhances neurogenesis and neuronal restitution. Our data showed that RA-NP enhanced endothelial cell proliferation and tubule network formation and protected against ischaemia-induced death...
April 21, 2016: Nanoscale
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