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https://www.readbyqxmd.com/read/27914723/evaluation-of-knee-cartilage-thickness-a-comparison-between-ultrasound-and-magnetic-resonance-imaging-methods
#1
Randy J Schmitz, Hsin-Min Wang, Daniel R Polprasert, Robert A Kraft, Brian G Pietrosimone
BACKGROUND: Establishing clinically accessible measures of cartilage health is critical for assessing effectiveness of protocols to reduce risk of osteoarthritis (OA) development and progression. Cartilage thickness is one important measure in describing both OA development and progression. The objective was to determine the relationship between ultrasound and MRI measures of cartilage thickness in the medial femoral condyle. METHODS: Mean cartilage thicknesses of the left medial femoral cartilage were measured via T1 weighted MRI and ultrasound imaging from transverse, anterior, middle, and posterior medial femoral regions in 10 healthy females (Mean±Std Dev) (1...
November 30, 2016: Knee
https://www.readbyqxmd.com/read/27914355/characterisation-of-fine-grained-tailings-from-a-marble-processing-plant-and-their-acute-effects-on-the-copepod-calanus-finmarchicus
#2
Julia Farkas, Dag Altin, Karen M Hammer, Kaja C Hellstrøm, Andy M Booth, Bjørn Henrik Hansen
Submarine tailing disposal (STD) of mining waste is practiced as an alternative to land fill disposal in several countries. Knowledge regarding the environmental implications of STD on fjord and other marine ecosystems, including the pelagic environment, is scarce. In this study, we characterised the particle shape, size and metal content of the fine-grained fraction of tailings (FGT) from a Norwegian marble processing plant and investigated their acute toxicity and impact on feeding rate in adult Calanus finmarchicus...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914283/binding-pattern-of-intermediate-udp-4-keto-xylose-to-human-udp-xylose-synthase-synthesis-and-std-nmr-of-model-keto-saccharides
#3
Claudia Puchner, Thomas Eixelsberger, Bernd Nidetzky, Lothar Brecker
Human UDP-xylose synthase (hUXS1) exclusively converts UDP-glucuronic acid to UDP-xylose via intermediate UDP-4-keto-xylose (UDP-Xyl-4O). Synthesis of model compounds like methyl-4-keto-xylose (Me-Xyl-4O) is reported to investigate the binding pattern thereof to hUXS1. Hence, selective oxidation of the desired hydroxyl function required employment of protecting group chemistry. Solution behavior of synthesized keto-saccharides was studied without enzyme via (1)H and (13)C NMR spectroscopy with respect to existent forms in deuterated potassium phosphate buffer...
November 5, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27911361/spin-saturation-transfer-difference-nmr-sstd-nmr-a-new-tool-to-obtain-kinetic-parameters-of-chemical-exchange-processes
#4
María Teresa Quirós, Colin Macdonald, Jesús Angulo, María Paz Muñoz
This detailed protocol describes the new Spin Saturation Transfer Difference Nuclear Magnetic Resonance protocol (SSTD NMR), recently developed in our group to study processes of mutual-site chemical exchange that are difficult to analyze by traditional methods. As the name suggests, this method combines the Spin Saturation Transfer method used for small molecules, with the Saturation Transfer Difference (STD) NMR method employed for the study of protein-ligand interactions, by measuring transient spin saturation transfer along increasing saturation times (build-up curves) in small organic and organometallic molecules undergoing chemical exchange...
November 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27902936/how-restful-is-it-with-all-that-noise-comparison-of-interleaved-silent-steady-state-isss-and-conventional-imaging-in-resting-state-fmri
#5
J Andoh, M Ferreira, I R Leppert, R Matsushita, B Pike, R J Zatorre
Resting-state fMRI studies have become very important in cognitive neuroscience because they are able to identify BOLD fluctuations in brain circuits involved in motor, cognitive, or perceptual processes without the use of an explicit task. Such approaches have been fruitful when applied to various disordered populations, or to children or the elderly. However, insufficient attention has been paid to the consequences of the loud acoustic scanner noise associated with conventional fMRI acquisition, which could be an important confounding factor affecting auditory and/or cognitive networks in resting-state fMRI...
November 27, 2016: NeuroImage
https://www.readbyqxmd.com/read/27896490/cerebrospinal-fluid-levels-of-neurofilament-light-chain-in-multiple-system-atrophy-relative-to-parkinson-s-disease-a-meta-analysis
#6
Xiaohui Hu, Yan Yang, Daokai Gong
As a biomarker of axonal injury, neurofilament light chain (NFL) in multiple system atrophy (MSA) patients and Parkinson's disease (PD) patients has been investigated by numerous studies. However, cerebrospinal fluid (CSF) NFL changes are conflicting in MSA patients relative to PD patients to date. Therefore, the current study was carried out to find out possible heterogeneity sources. Furthermore, "Neurofilament", "Neurofilament light chain" and "Multiple system atrophy" were employed to search "PubMed", "Springer" and "Medline" databases until August 2016 with standard mean difference (Std...
November 28, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27893745/public-stigma-against-people-with-mental-illness-in-jimma-town-southwest-ethiopia
#7
Yared Reta, Markos Tesfaye, Eshetu Girma, Sandra Dehning, Kristina Adorjan
BACKGROUND: Stigma towards people with mental illness (PWMI) can result in low self-esteem and isolation and threaten employment. Therefore, this study aimed to assess the magnitude of public stigma against PWMI and factors associated with it among Jimma town residents. METHODS: A community-based, cross-sectional, descriptive study was conducted in adult residents of Jimma town. Data were collected among 820 randomly selected residents with the interviewer-administered Community Attitudes toward the Mentally Ill (CAMI) scale...
2016: PloS One
https://www.readbyqxmd.com/read/27893604/implementation-of-preexposure-prophylaxis-for-human-immunodeficiency-virus-prevention-among-men-who-have-sex-with-men-at-a-new-england-sexually-transmitted-diseases-clinic
#8
Philip A Chan, Tiffany R Glynn, Catherine E Oldenburg, Madeline C Montgomery, Ashley E Robinette, Alexi Almonte, Julia Raifman, Leandro Mena, Rupa Patel, Kenneth H Mayer, Laura S Beauchamps, Amy S Nunn
BACKGROUND: Preexposure prophylaxis (PrEP) is efficacious in preventing human immunodeficiency virus (HIV) among men who have sex with men (MSM). We assessed PrEP uptake among MSM presenting for services at a sexually transmitted diseases (STD) clinic. METHODS: Men who have sex with men presenting to the Rhode Island STD Clinic between October 2013 and November 2014 were educated about, and offered, PrEP. We categorized PrEP engagement using an implementation cascade to describe gaps in uptake which described MSM who: (1) were educated about PrEP, (2) indicated interest, (3) successfully received follow-up contact, (4) scheduled an appointment, (5) attended an appointment, and (6) initiated PrEP (ie, received a prescription)...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27893594/sexually-transmitted-disease-program-evolution-in-response-to-changes-in-the-public-health-environment-a-massachusetts-example
#9
Marion W Carter, Katherine K Hsu, Penny S Loosier, Brandy L Peterson Maddox, Sonal R Doshi, Karen Kroeger, Kevin Cranston
BACKGROUND: In 2008, the line item supporting sexually transmitted disease (STD) services in the Massachusetts state budget was cut as a result of budget shortfalls. Shortly thereafter, direct provision of STD clinical services supported by the Massachusetts Department of Public Health (MDPH) was suspended. Massachusetts Department of Public Health requested an initial assessment of its internal response and impact in 2010. A follow-up assessment occurred in September 2013. METHODS: In 2010 and 2013, 39 and 46 staff, respectively, from MDPH and from clinical partner agencies, were interviewed about changes in the role of the MDPH, partnerships, STD services, challenges, and recommendations...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27890946/prevalence-of-asymptomatic-infections-in-sexually-transmitted-diseases-attendees-diagnosed-with-bacterial-vaginosis-vaginal-candidiasis-and-trichomoniasis
#10
R Rajalakshmi, S Kalaivani
BACKGROUND: Sexually transmitted diseases (STD) are a major health problem affecting mostly young people in both developing and developed countries. STD in women causes both acute morbidity and complications such as infertility, ectopic pregnancy, low-birth weight, and prematurity. AIMS: The aim of the study is to assess the prevalence of bacterial vaginosis, vaginal candidiasis, and trichomoniasis among asymptomatic females attending STD outpatient department in a tertiary care hospital in South India...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27885598/identification-of-ligand-receptor-interactions-ligand-molecular-arrays-spr-and-nmr-methodologies
#11
Christopher J Day, Lauren E Hartley-Tassell, Victoria Korolik
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and Tsr. In 30 years since, no other direct receptor-ligand interaction had been described for bacteria, until the characterization of the C. jejuni aspartate and multiligand receptors (Hartley-Tassell et al. Mol Microbiol 75:710-730, 2010). While signal transduction components of many sensory pathways have now been characterized, ligand-receptor interactions remain elusive due to paucity of high-throughput screening methods...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27885546/target-specific-nmr-detection-of-protein-ligand-interactions-with-antibody-relayed-15-n-group-selective-std
#12
Anasztázia Hetényi, Zsófia Hegedűs, Roberta Fajka-Boja, Éva Monostori, Katalin E Kövér, Tamás A Martinek
Fragment-based drug design has been successfully applied to challenging targets where the detection of the weak protein-ligand interactions is a key element. (1)H saturation transfer difference (STD) NMR spectroscopy is a powerful technique for this work but it requires pure homogeneous proteins as targets. Monoclonal antibody (mAb)-relayed (15)N-GS STD spectroscopy has been developed to resolve the problem of protein mixtures and impure proteins. A (15)N-labelled target-specific mAb is selectively irradiated and the saturation is relayed through the target to the ligand...
November 24, 2016: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/27884934/chronic-neuropathic-pain-severity-is-determined-by-lesion-level-in-aquaporin-4-antibody-positive-myelitis
#13
George Tackley, Domizia Vecchio, Shahd Hamid, Maciej Jurynczyk, Yazhuo Kong, Rosie Gore, Kerry Mutch, Mark Woodhall, Patrick Waters, Angela Vincent, Maria Isabel Leite, Irene Tracey, Anu Jacob, Jacqueline Palace
IMPORTANCE: Chronic, intractable neuropathic pain is a common and debilitating consequence of neuromyelitis optica spectrum disorder (NMOSD) myelitis, with no satisfactory treatment; few studies have yet to explore its aetiology. OBJECTIVE: To establish if myelitis-associated chronic pain in NMOSD is related to the craniocaudal location of spinal cord lesions. METHOD: (1) Retrospective cohort of 76 aquaporin 4-antibody (AQP4-Ab)-positive patients from Oxford and Liverpool's national NMOSD clinics, assessing current pain and craniocaudal location of cord lesion contemporary to pain onset...
November 24, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27882589/attenuation-of-the-cyproterone-acetate-induced-testicular-hypofunction-by-a-novel-nutraceutical-lycopene-a-genomic-approach
#14
A Tripathy, A Ghosh, A Dey, B P Pakhira, D Ghosh
This study was designed to explore the cyproterone acetate (CPA)-induced andrological hypofunction and its correction by oral administration of lycopene. In this concern, spermatogenic, biochemical, histological and genomic profiles were studied. Cyproterone acetate administration for 1 month helped to develop infertile model rats. A significant recovery was noted in sperm motility, sperm count, sperm viability, hypo-osmotic swelling tail-coiled spermatozoa; activities of testicular ∆(5) , 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, catalase (CAT) and superoxide dismutase (SOD); and levels of conjugated diene (CD), malondialdehyde (MDA), testicular cholesterol and serum testosterone after the administration of lycopene at 1...
November 24, 2016: Andrologia
https://www.readbyqxmd.com/read/27882073/standard-versus-abdominal-lifting-and-compression-cpr
#15
Sisen Zhang, Qing Liu, Shupeng Han, Ziran Zhang, Yan Zhang, Yahua Liu, Jing Li, Lixiang Wang
Background. This study compared outcomes of abdominal lifting and compression cardiopulmonary resuscitation (ALP-CPR) with standard CPR (STD-CPR). Materials and Methods. Patients with cardiac arrest seen from April to December 2014 were randomized to receive standard CPR or ALP-CPR performed with a novel abdominal lifting/compression device. The primary outcome was return of spontaneous circulation (ROSC). Results. Patients were randomized to receive ALP-CPR (n = 40) and STD-CPR (n = 43), and the groups had similar baseline characteristics...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27876480/noise-dosimetry-for-tactical-environments
#16
Christopher J Smalt, Joe Lacirignola, Shakti K Davis, Paul T Calamia, Paula P Collins
Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with hearing loss that is growing at an increasing rate. In an effort to minimize hearing loss, the U.S. Department of Defense (DoD) updated its Hearing Conservation Program in 2010, and also has recently revised the DoD Design Criteria Standard Noise Limits (MIL-STD-1474E) which defines allowable noise levels in the design of all military acquisitions including weapons and vehicles...
November 20, 2016: Hearing Research
https://www.readbyqxmd.com/read/27866390/school-based-hiv-std-testing-behaviors-and-motivations-among-black-and-hispanic-teen-msm-results-from-a-formative-evaluation
#17
Elana Morris, Pablo Topete, Catherine N Rasberry, Catherine A Lesesne, Elizabeth Kroupa, Lisa Carver
BACKGROUND: This evaluation explores experiences with, and motivations for, human immunodeficiency virus (HIV) and sexually transmitted disease (STD) testing among black and Hispanic school-aged young men who have sex with men (YMSM). METHODS: Participants were recruited at community-based organizations that serve YMSM in New York City, Philadelphia, and San Francisco. Eligible participants were 13- to 19-year-old black or Hispanic males who reported attraction to or sexual behavior with other males and/or identified as gay or bisexual, and attended at least 90 days of school in the previous 18 months...
December 2016: Journal of School Health
https://www.readbyqxmd.com/read/27856739/fluorine-19-nmr-and-computational-quantification-of-isoflurane-binding-to-the-voltage-gated-sodium-channel-nachbac
#18
Monica N Kinde, Vasyl Bondarenko, Daniele Granata, Weiming Bu, Kimberly C Grasty, Patrick J Loll, Vincenzo Carnevale, Michael L Klein, Roderic G Eckenhoff, Pei Tang, Yan Xu
Voltage-gated sodium channels (NaV) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit NaV by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the existence of multiple isoflurane binding sites in NaV, but experimental binding data are lacking. Here we use site-directed placement of (19)F probes in NMR experiments to quantify isoflurane binding to the bacterial voltage-gated sodium channel NaChBac...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27843436/lifetime-multiple-mild-traumatic-brain-injuries-are-associated-with-cognitive-and-mood-symptoms-in-young-healthy-college-students
#19
Kyle C Vynorius, Alyssa M Paquin, Daniel R Seichepine
BACKGROUND/OBJECTIVES: Repetitive mild traumatic brain injury (mTBI, also known as concussion) has been associated with a range of long-term mood and cognitive deficits, including executive dysfunction. Previous research in athletes suggests that cognitive and mood problems are associated with a history of repetitive mTBI. However, to date, no studies have examined the impact of a lifetime accumulation of repetitive mTBIs on cognition, particularly executive functioning, and mood in a sample of young adults who were not athletes...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27842964/hygroscopic-behavior-of-water-soluble-matter-in-marine-aerosols-over-the-east-china-sea
#20
Yu Yan, Pingqing Fu, Bo Jing, Chao Peng, S K R Boreddy, Fan Yang, Lianfang Wei, Yele Sun, Zifa Wang, Maofa Ge
In this study, we investigated hygroscopic properties of water-soluble matter (WSM) in marine aerosols over the East China Sea, which were collected during a Natural Science Foundation of China (NSFC) sharing cruise in 2014. Hygroscopic growth factors (g) of WSM were measured by a hygroscopicity tandem differential mobility analyzer (H-TDMA) with an initial dry particle mobility diameter of 100nm. The observed g at 90% relative humidity (RH), g(90%)WSM, defined as the ratio of the particle diameter at 90% RH to that at RH<5% (initial dry diameter), ranged from 1...
November 11, 2016: Science of the Total Environment
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