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https://www.readbyqxmd.com/read/28644820/investigation-of-real-tissue-water-equivalent-path-lengths-using-an-efficient-dose-extinction-method
#1
Rongxiao Zhang, Esther Baer, Kyung-Wook Jee, Gregory C Sharp, Jay Flanz, Hsiao-Ming Lu
For proton therapy, an accurate conversion of CT HU to relative stopping power (RSP) is essential. Validation of the conversion based on real tissue samples is more direct than the current practice solely based on tissue substitutes and can potentially address variations over the population. Based on a novel dose extinction method, we measured water equivalent path lengths (WEPL) on animal tissue samples to evaluate the accuracy of CT HU to RSP conversion and potential variations over a population. A broad proton beam delivered a spread out Bragg peak to the samples sandwiched between a water tank and a 2D ion-chamber detector...
June 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28644609/galnac-tyrosine-is-a-ligand-of-plant-lectins-antibodies-and-human-and-murine-macrophage-galactose-type-lectins
#2
Ruslan Gibadullin, David Wayne Farnsworth, Joseph J Barchi, Jeffrey C Gildersleeve
In 2011, a new type of protein O-glycosylation was discovered in which N-acetylgalactosamine is attached to the side chain of tyrosine (GalNAc-Tyr). While present on dozens of proteins, the biological roles of GalNAc-Tyr are unknown. To gain insight into this new type of modification, we synthesized a group of GalNAc-Tyr glycopeptides, constructed microarrays, and evaluated potential recognition of GalNAc-Tyr by a series of glycan-binding proteins. Through a series of >150 microarray experiments, we assessed binding properties of a variety of plant lectins, monoclonal antibodies, and endogenous lectins...
June 23, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28642088/effect-of-pre-emptive-pregabalin-on-pain-management-in-patients-undergoing-laparoscopic-cholecystectomy-a-systematic-review-and-meta-analysis
#3
REVIEW
Yi Zhang, Yu Wang, Xi Zhang
BACKGROUND: Pre-emptive pregabalin might be beneficial to the patients undergoing laparoscopic cholecystectomy. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of pregabalin on pain management of patients undergoing laparoscopic cholecystectomy. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of pregabalin versus placebo on laparoscopic cholecystectomy were included...
June 19, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28629559/prospective-intra-individual-comparison-of-standard-dose-versus-reduced-dose-thoracic-ct-using-hybrid-and-pure-iterative-reconstruction-in-a-follow-up-cohort-of-pulmonary-nodules-effect-of-detectability-of-pulmonary-nodules-with-lowering-dose-based-on-nodule
#4
Varut Vardhanabhuti, Chun-Lap Pang, Sean Tenant, James Taylor, Christopher Hyde, Carl Roobottom
OBJECTIVES: To determine the diagnostic accuracy of lung nodule detection in thoracic CT using 2 reduced dose protocols comparing 3 available CT reconstruction algorithms (filtered back projection-FBP, adaptive statistical reconstruction-ASIR and model-based iterative reconstruction-MBIR) in a western population. MATERIALS AND METHODS: A prospective single-center study recruited 98 patients with written consent. Standard dose (STD) thoracic CT followed by 2 reduced-dose protocols using automatic tube current modulation (RD1) and fixed tube current (RD2) were performed and reconstructed with FBP, ASIR and MBIR with subsequent diagnostic accuracy analysis for nodule detection...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28629128/interactions-between-a-heparin-trisaccharide-library-and-fgf-1-analyzed-by-nmr-methods
#5
María José García-Jiménez, Sergio Gil-Caballero, Ángeles Canales, Jesús Jiménez-Barbero, José L de Paz, Pedro M Nieto
FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane receptor (FGFR), generates an intracellular signal that finally leads to cell division. The overall structure of the ternary complex Heparin:FGF-1:FGFR has been finally elucidated after some controversy and the interactions within the ternary complex have been deeply described. However, since the structure of the ternary complex was described, not much attention has been given to the molecular basis of the interaction between FGF-1 and the HSGAG...
June 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28627834/characteristics-and-distribution-of-penile-lesions-in-croatian-men-with-laboratory-confirmed-low-risk-and-high-risk-human-papillomavirus-hpv-infection
#6
Tomislav Mestrovic, Zora Profozic, Marijana Neuberg, Goran Kozina, Ivan Savic, Velimir Profozic
BACKGROUND: Studies that compare penoscopic evaluation with the results of molecular human papillomavirus (HPV) testing are scarce. This study assessed and compared both type and distribution of various penile lesions using penoscopy (peniscopy) technique in Croatian men with different, laboratory-confirmed HPV status. METHODS: From a large cohort of men attending an outpatient STD clinic for HPV testing, a total of 120 patients were randomly selected and grouped into those positive for low-risk HPV, high-risk HPV, both low-risk and highrisk HPV, and those with negative results...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627058/survey-nutrition-body-condition-and-activities-of-dogs-in-switzerland
#7
K Gerstner, A Liesegang
Interest in species-appropriate activities and nutrition of dogs increases. A huge variety of feedstuff available, myths and different feeding theories confuse dog owners and lead to inadequate nutrition of their pets. As one result, obesity in pets can be observed with a high incidence in veterinary practice. Although comorbidities of obesity are well known, only few pet owners realize consequently the necessity of weight reduction to support their pet's health. We hypothesized that pet owners in Switzerland underestimate body condition of their dogs and are unsure about how to manage nutritional challenges...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28624925/liver-fibrosis-in-vivo-evaluation-using-intravoxel-incoherent-motion-derived-histogram-metrics-with-histopathologic-findings-at-3-0-t
#8
Fubi Hu, Ru Yang, Zixing Huang, Min Wang, Hanmei Zhang, Xu Yan, Bin Song
PURPOSE: To retrospectively determine the feasibility of intravoxel incoherent motion (IVIM) imaging based on histogram analysis for the staging of liver fibrosis (LF) using histopathologic findings as the reference standard. METHODS: 56 consecutive patients (14 men, 42 women; age range, 15-76, years) with chronic liver diseases (CLDs) were studied using IVIM-DWI with 9 b-values (0, 25, 50, 75, 100, 150, 200, 500, 800 s/mm(2)) at 3.0 T. Fibrosis stage was evaluated using the METAVIR scoring system...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28613394/regular-exercise-behavior-is-related-to-lower-extremity-muscle-strength-in-patients-with-type-2-diabetes-data-from-the-muscle-std-study
#9
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda
Owing to several contributing factors, continuation of exercise therapy is difficult in patients with type 2 diabetes. One potential factor that has not been well examined is the influence of muscle strength on regular exercise behavior. We examined the relationship between regular exercise behavior and knee extension force (KEF) in 1,442 patients with type 2 diabetes. In sex-specific univariate analysis, KEF was significantly higher in patients with regular exercise than in patients without regular exercise...
June 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28612588/analysis-of-knowledge-level-in-brasilian-students-about-human-papillomavirus-infection-and-development-of-penile-cancer
#10
George Kemil Abdalla, Emanuella Francisco Fajardo, Bruno Belmonte Martinelli Gomes, Thiago Mantello Bianco, Ana Karina Marques Salge, Eduardo Elias Vieira de Carvalho, Marlize Moura Dos Reis, Dayana Pousa Siqueira Abrahão, Douglas Reis Abdalla
Introduction: Human papillomavirus (HPV), belonging to the Papovavirida family, is the most prevalent sexually transmitted disease (STD) agent worldwide. In Brazil, it is estimated that there are 3-6 million people infected with HPV. Aim: The aim of this study was to evaluate the knowledge of young male students about penis cancer related to HPV infection. Methods: This exploratory and quantitative study was conducted to analyze answers of 242 male students attending a private college located in Uberaba city, Minas Gerais state, Brazil, during 2015...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28608795/human-papillomavirus-vaccination-among-young-men-who-have-sex-with-men-and-transgender-women-in-2-us-cities-2012-2014
#11
Pamina M Gorbach, Ryan Cook, Beau Gratzer, Thomas Collins, Adam Parrish, Janell Moore, Peter R Kerndt, Richard A Crosby, Lauri E Markowitz, Elissa Meites
BACKGROUND: Since 2011, in the United States, quadrivalent human papillomavirus (HPV) vaccine has been recommended for boys aged 11 to 12 years, men through age 21, and men who have sex with men (MSM) through age 26. We assessed HPV vaccination coverage and factors associated with vaccination among young MSM (YMSM) and transgender women (TGW) in 2 cities. METHODS: During 2012-2014, 808 YMSM and TGW aged 18 to 26 years reported vaccination status in a self-administered computerized questionnaire at 3 sexually transmitted disease (STD) clinics in Los Angeles and Chicago...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28608788/increases-in-the-rate-of-neisseria-gonorrhoeae-among-gay-bisexual-and-other-men-who-have-sex-with-men-findings-from-the-sexually-transmitted-disease-surveillance-network-2010-2015
#12
Mark R Stenger, Preeti Pathela, Greta Anschuetz, Heidi Bauer, Julieann Simon, Robert Kohn, Christina Schumacher, Elizabeth Torrone
BACKGROUND: Inequalities in Neisseria gonorrhoeae (gonorrhea) burden by sexual minority status in the United States are difficult to quantify. Sex of sex partner is not routinely collected for reported cases. Population estimates of men who have sex with men (MSM) necessary to calculate case rates have not been available until recently. For these reasons, trends in reported gonorrhea rates among MSM have not been described across multiple jurisdictions. METHODS: We estimated of the number of MSM cases reported in 6 jurisdictions continuously participating in the STD Surveillance Network 2010-2015 based on interviews with a random sample of cases...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28608786/new-human-immunodeficiency-virus-diagnosis-independently-associated-with-rectal-gonorrhea-and-chlamydia-in-men-who-have-sex-with-men
#13
Lindley A Barbee, Christine M Khosropour, Julia C Dombrowksi, Matthew R Golden
BACKGROUND: Rectal sexually transmitted infections (STI) have been associated with human immunodeficiency virus (HIV) diagnosis, but inferring a causal association requires disentangling them from receptive anal intercourse (RAI). METHODS: We conducted a stratified case-control study by frequency matching 4 controls to each case within year using clinical data from men who have sex with men (MSM) attending the Seattle STD Clinic 2001 to 2014. Cases were MSM with a new HIV diagnosis and negative HIV test at 12 months or less...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28608751/molecular-modelling-studies-of-kdr-mutations-in-voltage-gated-sodium-channel-revealed-significant-conformational-variations-contributing-to-insecticide-resistance
#14
Nanda Kumar Yellapu, Jeyakodi Gopal, Gunasekaran Kasinahtan, Jambulingam Purushothaman
Voltage gated sodium channels (VGSC) of mosquito vectors are the primary targets of DDT and other synthetic pyrethroids used in public health programs. The knockdown resistant (kdr) mutations in VGSC are associated with the insecticide resistance especially in Anophelines. The present study is aimed to emphasize and demarcate the impact of three kdr-mutations such as L1014S, L1014F and L1014H on insecticide resistance. The membrane model of sodium transport domain of VGSC (STD-VGSC) was constructed using de novo approach based on domain and trans-membrane predictions...
June 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28600234/rescsrf-algorithm-to-automatically-extract-cheyne-stokes-respiration-features-from-respiratory-signals
#15
Faizan Javed, Henrik Fox
OBJECTIVE: Cheyne-Stokes respiration (CSR) related features are significantly associated with cardiac dysfunction. Scoring of these features is labor-intensive and time-consuming. To automate the scoring process, an algorithm (ResCSRF) has been developed to extract these features from nocturnal measurement of respiratory signals. METHODS: ResCSRF takes 4 signals (nasal flow, thorax, abdomen and finger oxygen saturation) as input. It first detects CSR cycles and then calculates the respiratory features [cyclelength (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF)]...
June 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28590477/evaluation-of-ligand-based-nmr-screening-methods-to-characterize-small-molecule-binding-to-hiv-1-glycoprotein-41
#16
Shidong Chu, Guangyan Zhou, Miriam Gochin
Small molecule inhibitors of glycoprotein-41 (gp41) are able to prevent HIV infection by binding to a hydrophobic pocket (HP) contained within the gp41 ectodomain, and preventing progression of fusion. There is little structural information on gp41-ligand complexes, owing to hydrophobicity of the ligands, occlusion of the HP in folded gp41 ectodomain, and failure to form crystals of complexes. Here we used an engineered gp41 ectodomain protein containing an exposed HP and a small molecule designed to bind with weak affinity to the HP...
June 28, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28590392/pilot-studies-examining-feasibility-of-substance-use-disorder-screening-and-treatment-linkage-at-urban-sexually-transmitted-disease-clinics
#17
Jan Gryczynski, Courtney D Nordeck, Shannon Gwin Mitchell, Kathleen R Page, Luke L Johnsen, Kevin E O'Grady, Robert P Schwartz
BACKGROUND: Sexually transmitted disease (STD) clinics provide critical public health services for screening and treatment of sexually transmitted infections throughout the United States. These settings serve high-risk populations, often on a walk-in basis, and may be promising venues for integrating substance use disorder (SUD) services. METHODS: We report findings from 2 pilot studies conducted at Baltimore City Health Department's STD clinics. The screening study characterized rates of SUDs among STD clinic patients...
June 5, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28589723/molecular-interaction-between-salivary-proteins-and-food-tannins
#18
Mafalda Silva, Ignacio García-Estévez, Elsa Brandão, Nuno Mateus, Victor De Freitas, Susana Soares
Polyphenols interaction with salivary proteins (SP) has been related with organoleptic features such as astringency. The aim of this work was to study the interaction between some human SP and tannins through two spectroscopic techniques, fluorescence quenching and Saturation Transfer Difference-Nuclear Magnetic Resonance (STD-NMR). Generally, the results showed a significant interaction between SP and both condensed tannins and ellagitannins. Herein, STD-NMR proved to be a useful tool to map tannins' epitopes of binding, while fluorescence quenching allowed to discriminate binding affinities...
June 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28589269/improving-std-screening-rates-on-a-university-campus
#19
Amanda Myers, Sherrie P McCaskill, Kathryn VanRavenstein
Gonorrhea and chlamydia infections have a high incidence among young adults. To increase screening rates among individuals aged 25 years of age and younger on a university campus, this quality improvement project was implemented to improve providers' knowledge of CDC guidelines through education. Education was provided to providers and staff members at a health clinic on a private residential university campus through informational sessions to increase knowledge of guideline-directed screening for gonorrhea and chlamydia...
June 6, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28587455/insights-on-the-interaction-between-transthyretin-and-a%C3%AE-in-solution-a-saturation-transfer-difference-std-nmr-analysis-of-the-role-of-iododiflunisal
#20
Ana Gimeno, Luis M Santos, Mobina Alemi, Josep Rivas, Daniel Blasi, Ellen Y Cotrina, Jordi Llop, Gregorio Valencia, Isabel Cardoso, Jordi Quintana, Gemma Arsequell, Jesús Jiménez-Barbero
Several strategies against Alzheimer disease (AD) are directed to target Aβ-peptides. The ability of transthyretin (TTR) to bind Aβ-peptides and the positive effect exerted by some TTR stabilizers for modulating the TTR-Aβ interaction have been previously studied. Herein, key structural features of the interaction between TTR and the Aβ(12-28) peptide (3), the essential recognition element of Aβ, have been unravelled by STD-NMR spectroscopy methods in solution. Molecular aspects related to the role of the TTR stabilizer iododiflunisal (IDIF, 5) on the TTR-Aβ complex have been also examined...
June 16, 2017: Journal of Medicinal Chemistry
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