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https://www.readbyqxmd.com/read/28227506/a-pdms-based-optical-waveguide-for-transcutaneous-powering-of-microelectrode-arrays
#1
Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin, Ali Ersen, Mesut Sahin
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226543/development-of-a-novel-probabilistic-algorithm-for-localization-of-rotors-during-atrial-fibrillation
#2
Prasanth Ganesan, Anthony Salmin, Elizabeth M Cherry, Behnaz Ghoraani, Prasanth Ganesan, Anthony Salmin, Elizabeth M Cherry, Behnaz Ghoraani, Elizabeth M Cherry, Prasanth Ganesan, Behnaz Ghoraani, Anthony Salmin
Atrial fibrillation (AF) is an irregular heart rhythm that can lead to stroke and other heart-related complications. Catheter ablation has been commonly used to destroy triggering sources of AF in the atria and consequently terminate the arrhythmia. However, efficient and accurate localization of the AF sustaining sources known as rotors is a major challenge in catheter ablation. In this paper, we developed a novel probabilistic algorithm that can adaptively guide a Lasso diagnostic catheter to locate the center of a rotor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222243/studies-on-the-binding-of-modest-modulators-of-the-human-enzyme-sirtuin-6-using-std-nmr
#3
Beatriz E Bolívar, John T Welch
Pyrazinamide (PZA), an essential constituent of short course tuberculosis chemotherapy, binds weakly but selectively to Sirtuin 6 (SIRT6). Despite structural similarities between nicotinamide (NAM), PZA, and pyrazinoic acid (POA), these inhibitors modulate SIRT6 via different mechanisms and binding sites, as suggested by Saturation Transfer Difference (STD) Nuclear Magnetic Resonance (NMR). Available experimental evidence, such as that derived from crystal structures and kinetic experiments, is of only limited utility in the elucidation of the mechanistic details of sirtuin inhibition by NAM or other inhibitors...
February 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28217614/somatic-symptoms-after-sexual-behavior-with-fear-of-four-sexually-transmitted-diseases-a-proposal-of-novel-disorder
#4
Kentaro Iwata, Yoshiaki Katsuda
Somatic symptom disorder (SSD) often leads to frequent doctor visit not only to psychiatrists but also to various kinds of physicians. We encountered four cases of SSD, particularly associated with sexual intercourse and fear of sexually transmitted diseases (STDs). To best of our knowledge, there is no independent clinical entity assigned to this phenomenon. Here, we propose a variation of SSD called four STD as an independent clinical entity since the presentation of this disorder is very distinctive, and lack of awareness of it may lead to unnecessary laboratory workup and antimicrobial prescription as well as augmented anxiety of the patients with potential "doctor shopping...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28208724/assessing-the-knowledge-level-attitudes-risky-behaviors-and-preventive-practices-on-sexually-transmitted-diseases-among-university-students-as-future-healthcare-providers-in-the-central-zone-of-malaysia-a-cross-sectional-study
#5
Adigun Temiloluwa Folasayo, Afolayan John Oluwasegun, Suhailah Samsudin, Siti Nor Sakinah Saudi, Malina Osman, Rukman Awang Hamat
This study was done to assess the knowledge, attitudes, risky behaviors and preventive practices related to sexually-transmitted diseases (STDs) among health and non-health sciences university students as future healthcare providers in Malaysia. A total of 700 health and non-health sciences university students (255 male; 445 female) aged between 17 and 30 years were surveyed by using a self-administered questionnaire. The majority (86.6%) had heard of STDs, and 50.4% knew STDs could present without symptoms...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207701/std-results-in-minutes
#6
Erin Biba
No abstract text is available yet for this article.
February 14, 2017: Scientific American
https://www.readbyqxmd.com/read/28199868/sexual-dysfunction-and-central-obesity-in-patients-with-first-episode-psychosis
#7
C Theleritis, S Bonaccorso, N Habib, D Stahl, F Gaughran, S Vitoratou, Z Atakan, A Kolliakou, P Gardner Sood, P Dazzan, T R Marques, P McGuire, K Greenwood, J Eberhard, J Breedvelt, S Ferracuti, M Di Forti, R M Murray, S Smith
BACKGROUND: In recent years the association between sexual dysfunction (SD) and obesity in the general population has drawn major attention. Although sexual dysfunction is common in psychosis, its relationship with weight gain and obesity remains unclear. AIMS: To investigate the association between sexual dysfunction and obesity in a cohort of patients with first episode psychosis. METHOD: Sexual function was assessed in a cohort of patients with first episode psychosis using the Sexual Function Questionnaire (SFQ)...
February 12, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28199417/physical-activity-prevents-alterations-in-mitochondrial-ultrastructure-and-glucometabolic-parameters-in-a-high-sugar-diet-model
#8
Karina Barbosa de Queiroz, Kinulpe Honorato-Sampaio, Joamyr Victor Rossoni Júnior, Diego Andrade Leal, Angélica Barbosa G Pinto, Lenice Kappes-Becker, Elisio Alberto Evangelista, Renata Guerra-Sá
Endurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD). Weaned male Wistar rats fed with a standard diet or a HSD (68% carbohydrate) were subjected to 60 minutes of regular physical activity by swimming (without workload) for four- (20 sessions) or eight-week (40 sessions) periods...
2017: PloS One
https://www.readbyqxmd.com/read/28188882/intelligibility-in-speech-maskers-with-a-binaural-cochlear-implant-sound-coding-strategy-inspired-by-the-contralateral-medial-olivocochlear-reflex
#9
Enrique A Lopez-Poveda, Almudena Eustaquio-Martín, Joshua S Stohl, Robert D Wolford, Reinhold Schatzer, José M Gorospe, Santiago Santa Cruz Ruiz, Fernando Benito, Blake S Wilson
We have recently proposed a binaural cochlear implant (CI) sound processing strategy inspired by the contralateral medial olivocochlear reflex (the MOC strategy) and shown that it improves intelligibility in steady-state noise (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). The aim here was to evaluate possible speech-reception benefits of the MOC strategy for speech maskers, a more natural type of interferer. Speech reception thresholds (SRTs) were measured in six bilateral and two single-sided deaf CI users with the MOC strategy and with a standard (STD) strategy...
February 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28181233/sebaceous-carcinoma-in-solid-organ-transplant-recipients
#10
Elika Hoss, Steven A Nelson, Amit Sharma
BACKGROUND: Though a rare tumor, sebaceous carcinoma is relatively well-described in immunocompetent patients, in whom it often occurs in a periorbital distribution where it has an overall poor prognosis with a high metastasis rate. The effect of transplant-related immunosuppression on the development of sebaceous carcinoma and its outcomes has not been characterized. METHODS: We collected 9 cases from a single institution of patients developing sebaceous carcinoma after solid organ transplantation...
February 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#11
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28168593/a-community-needs-index-for-adolescent-pregnancy-prevention-program-planning-application-of-spatial-generalized-linear-mixed-models
#12
Glen D Johnson, Kristine Mesler, Marilyn A Kacica
Objective The objective is to estimate community needs with respect to risky adolescent sexual behavior in a way that is risk-adjusted for multiple community factors. Methods Generalized linear mixed modeling was applied for estimating teen pregnancy and sexually transmitted disease (STD) incidence by postal ZIP code in New York State, in a way that adjusts for other community covariables and residual spatial autocorrelation. A community needs index was then obtained by summing the risk-adjusted estimates of pregnancy and STD cases...
February 6, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28168158/insights-into-the-binding-of-cyclic-rgd-peptidomimetics-to-%C3%AE-5%C3%AE-1-integrin-by-using-live-cell-nmr-and-computational-studies
#13
Ileana Guzzetti, Monica Civera, Francesca Vasile, Daniela Arosio, Cristina Tringali, Umberto Piarulli, Cesare Gennari, Luca Pignataro, Laura Belvisi, Donatella Potenza
The interaction of a small library of cyclic DKP-RGD peptidomimetics with α5β1 integrin has been investigated by means of an integrated experimental and computational approach. Bioaffinity NMR techniques, including saturation transfer difference (STD) and transferred NOESY, were applied to the ligands in a suspension of intact MDA-MB-231 breast cancer cells, in which integrin α5β1 is highly expressed. The NMR data were compared with the docking calculations of the RGD ligands in the crystal structure of the α5β1 binding site, and were integrated with competitive binding assays to the purified α5β1 integrin...
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28162170/-effects-of-different-sulfonylureas-on-the-warm-up-phenomenon-in-diabetes-patients-with-coronary-artery-disease
#14
M Zheng, L Z Li, Z A Jiang, L H Li, Y G Feng, X H Fu
Objective: To explore the different effects of chronic treatment with glibenclamide and gliclazide on the warm-up phenomenon in diabetes patients with coronary artery disease. Methods: A total of seventy-one patients with chronic stable angina and diabetes who were positive for exercise test and was proven that the stenosis degree was 70%-90% in at least one major branch through coronary angiogram were included into the study.They were divided into three groups, diet control group (DMD), glibenclamide group (DMG1) and gliclazide group (DMG2), according to the treatment of diabetes...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28162106/chronic-administration-of-grape-seed-polyphenols-attenuates-the-development-of-hypertension-and-improves-other-cardiometabolic-risk-factors-associated-with-the-metabolic-syndrome-in-cafeteria-diet-fed-rats
#15
Zara Pons, Maria Margalef, Francisca I Bravo, Anna Arola-Arnal, Begoña Muguerza
The effects of grape-seed polyphenols against the development of hypertension and other cardiometabolic conditions associated with the metabolic syndrome (MetS) were studied in rats fed a high-fat, high-carbohydrate diet, known as the cafeteria (CAF) diet. Two groups of Wistar rats were fed standard (STD) or CAF diets for 12 weeks. The CAF diet-fed rats were administered different doses of a low-molecular-weight grape-seed polyphenol extract (LM-GSPE) (25, 100 and 200 mg/kg per d) or vehicle daily, and the STD diet-fed rats were administered LM-GSPE (100 mg/kg per d) or vehicle using ten animals per group...
February 6, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28159907/acid-sensing-ion-channels-activated-by-evoked-released-protons-modulate-synaptic-transmission-at-the-mouse-calyx-of-held-synapse
#16
Carlota González-Inchauspe, Francisco J Urbano, Mariano N Di Guilmi, Osvaldo D Uchitel
: Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in the CNS. A drop in extracellular pH induces transient inward currents (IASIC) in postsynaptic MNTB neurons from wild type (WT) mice. The inhibition of IASIC by psalmotoxin-1 (PcTx1) and the absence of these currents in knock out mice for ASIC-1a subunit (ASIC1a(-/-)) suggest that homomeric ASIC-1a channels are mediating these currents in MNTB neurons...
February 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28152012/what-is-the-economic-evidence-for-mhealth-a-systematic-review-of-economic-evaluations-of-mhealth-solutions
#17
Sarah J Iribarren, Kenrick Cato, Louise Falzon, Patricia W Stone
BACKGROUND: Mobile health (mHealth) is often reputed to be cost-effective or cost-saving. Despite optimism, the strength of the evidence supporting this assertion has been limited. In this systematic review the body of evidence related to economic evaluations of mHealth interventions is assessed and summarized. METHODS: Seven electronic bibliographic databases, grey literature, and relevant references were searched. Eligibility criteria included original articles, comparison of costs and consequences of interventions (one categorized as a primary mHealth intervention or mHealth intervention as a component of other interventions), health and economic outcomes and published in English...
2017: PloS One
https://www.readbyqxmd.com/read/28146186/-the-current-prevalence-of-chlamydia-trachomatis-infection-among-teenagers-and-young-asymptomatic-chilean-women-justifies-the-periodic-surveillance
#18
Milena Zamboni, Constanza Ralph, Patricia García, Mauricio Cuello
INTRODUCTION: Chlamydia trachomatis infection constitutes the most common sexual transmitted disease (STD) among young women. International studies demonstrate that prevalence changes over time and also according to places. AIMS: To estimate the prevalence of this infection among asymptomatic Chilean women (15 to 24 years old) and correlating with risk factor occurrence. METHODS: Transversal cohort study to identify C. trachomatis infection through a diagnostic kit designed to detect and amplify cryptic plasmid DNA by quantitative PCR from endocervical sample...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28145800/hiv-and-sexually-transmitted-disease-testing-behavior-among-adolescent-sexual-minority-males-analysis-of-pooled-youth-risk-behavior-survey-data-2005-2013
#19
Akshay Sharma, Li Yan Wang, Richard Dunville, Rachel K Valencia, Eli S Rosenberg, Patrick S Sullivan
PURPOSE: Adolescent sexual minority males (ASMM) comprise a high-risk group that may benefit from expanded human immunodeficiency virus (HIV) and sexually transmitted disease (STD) prevention services. The purpose of this study was to estimate the prevalence of HIV and STD testing among ASMM from pooled high school Youth Risk Behavior Surveys (YRBSs). METHODS: Data came from 26 YRBSs from 2005 to 2013, which included questions on sexual identity and/or sex of sexual contacts and questions on ever being tested for HIV and/or STDs...
February 1, 2017: LGBT Health
https://www.readbyqxmd.com/read/28132954/dietary-magnesium-intake-alters-age-related-changes-in-rat-adipose-tissue-cellularity
#20
Sylvie Devaux, Markus Adrian, Pascal Laurant, Alain Berthelot, Annie Quignard-Boulangé
Obesity and related metabolic diseases are associated with increased risk of cardiovascular disease. We have previously shown the beneficial effects of dietary magnesium (Mg) supplementation on cardiovascular disease in rats. Therefore, we aimed to examine the effect of an Mg-deficient or supplemented diet on adipose tissue cellularity changes during aging, and on blood pressure (BP), in rats. Male rats received for one (young adult) or 22 months (old), an Mg-deficient (Def) (150 mg/kg), standard (Std) (800 mg/kg) or Mg-supplemented (Sup) (3200 mg/kg) diet...
April 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
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