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https://www.readbyqxmd.com/read/29135370/pharmacokinetics-based-adjusted-versus-standard-dose-of-ribavirin-does-not-improve-virologic-response-rates-in-chronic-hepatitis-c-genotype-4-patients-a-randomized-controlled-trial
#1
Ibrahim H Altraif, Faisal Sanai, Mohammed A Babatin, Abduljaleel A Alalwan, Ayman A Abdo, Waleed Alhamoudi, Musthafa Peedikayil, Hamdan Alghamdi, Fahad Alsohaibani, Khalid A Alswat, Shazia Murtaza, Abdullah Alghamdi, Sara Altraif, Abdulrahman Aljumah, Fayaz A Handoo, Abdulkareem M AlBekairy, Hamad I Al-Ashgar, Mohammed Alquaiz, Mohammed A Alblawi, Waleed AlTamimi, Véronique Loustaud-Ratti, Pierre Marquett
Optimal doses of Ribavirin (RBV) for hepatitis C virus (HCV) treatment are not known. To assess the safety and efficacy of PegIFNalfa-2a in combination with an adjusted (ADJ) RBV dose based on early pharmacokinetics versus a fixed standard (STD) dose of RBV in chronic HCV genotype (GT) 4-naive patients in a randomized trial. One hundred eighty-one patients were randomized. The baseline variables were similar in both arms and females were 50.3% of the patients, 76.5% had minimal-moderate fibrosis (F0-2). Sustained virologic response (SVR) was achieved in 99 (54...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29130805/rehabilitative-success-after-brain-trauma-by-augmenting-a-subtherapeutic-dose-of-environmental-enrichment-with-galantamine
#2
Patricia B de la Tremblaye, Jody L Wellcome, Benjamin Wells de Witt, Jeffrey P Cheng, Elizabeth R Skidmore, Corina O Bondi, Anthony E Kline
BACKGROUND: Environmental enrichment (EE) confers benefits after traumatic brain injury (TBI) when provided daily for > 6 hours, but not 2 or 4 hours, which more accurately reflects the daily amount of clinical rehabilitation. The lack of benefit with sub-therapeutic EE suggests that augmentation with galantamine (GAL), which enhances cognition after TBI, may be indicated to confer benefits. OBJECTIVE: To test the hypothesis that 2 and 4 hours of EE paired with GAL will provide benefits comparable to 24 hours of EE alone...
November 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29128296/sexual-and-reproductive-health-care-receipt-among-young-males-aged-15-24
#3
Arik V Marcell, Susannah E Gibbs, Nanlesta A Pilgrim, Kathleen R Page, Renata Arrington-Sanders, Jacky M Jennings, Penny S Loosier, Patricia J Dittus
PURPOSE: This study aimed to describe young men's sexual and reproductive health care (SRHC) receipt by sexual behavior and factors associated with greater SRHC receipt. METHODS: There were 427 male patients aged 15-24 who were recruited from 3 primary care and 2 sexually transmitted disease (STD) clinics in 1 urban city. Immediately after the visit, the survey assessed receipt of 18 recommended SRHC services across four domains: screening history (sexual health, STD/HIV test, family planning); laboratories (STDs/HIV); condom products (condoms/lubrication); and counseling (STD/HIV risk reduction, family planning, condoms); in addition, demographic, sexual behavior, and visit characteristics were examined...
November 8, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29128293/test-retest-reliability-of-sit-to-stand-and-stand-to-sit-analysis-in-people-with-and-without-chronic-non-specific-low-back-pain
#4
Mohammad Reza Pourahmadi, Ismail Ebrahimi Takamjani, Shapour Jaberzadeh, Javad Sarrafzadeh, Mohammad Ali Sanjari, Rasool Bagheri, Elham Jannati
BACKGROUND: Sit-to-stand (STD) and stand-to-sit (SIT) analysis can provide information on functional independence in daily activities in patients with low back pain (LBP). However, in order for measurements to be clinically useful, data on psychometric properties should be available. OBJECTIVES: The main purpose was to investigate intra-rater reliability of STD and SIT tasks in participants with and without chronic non-specific LBP (CNLBP). The second purpose was to detect any differences in lumbar spine and hips sagittal plane kinematics and coordination between asymptomatic individuals and CNLBP patients during STD and SIT...
November 6, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29114189/computer-vision-syndrome-prevalence-knowledge-and-associated-factors-among-saudi-arabia-university-students-is-it-a-serious-problem
#5
Sultan H Al Rashidi, H Alhumaidan
Objectives: Computers and other visual display devices are now an essential part of our daily life. With the increased use, a very large population is experiencing sundry ocular symptoms globally such as dry eyes, eye strain, irritation, and redness of the eyes to name a few. Collectively, all such computer related symptoms are usually referred to as computer vision syndrome (CVS). The current study aims to define the prevalence, knowledge in community, pathophysiology, factors associated, and prevention of CVS...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29113739/structural-insights-into-the-interaction-of-a-monoclonal-antibody-and-nodal-peptides-by-std-nmr-spectroscopy
#6
Luisa Calvanese, Annalia Focà, Annamaria Sandomenico, Giuseppina Focà, Andrea Caporale, Nunzianna Doti, Emanuela Iaccarino, Antonio Leonardi, Gabriella D'Auria, Menotti Ruvo, Lucia Falcigno
Nodal is a growth factor expressed during early embryonic development, but reactivated in several advanced-stage cancers. Targeting of Nodal signaling, which occurs via the binding to Cripto-1 co-receptor, results in inhibition of cell aggressiveness and reduced tumor growth. The Nodal binding region to Cripto-1 was identified and targeted with a high affinity monoclonal antibody (3D1). By STD-NMR technique, we investigated the interaction of Nodal fragments with 3D1 with the aim to elucidate at atomic level the interaction surface...
October 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29113135/nonalcoholic-fatty-liver-disease-is-exacerbated-in-high-fat-diet-fed-gnotobiotic-mice-by-colonization-with-the-gut-microbiota-from-patients-with-nonalcoholic-steatohepatitis
#7
Chien-Chao Chiu, Yung-Hao Ching, Yen-Peng Li, Ju-Yun Liu, Yen-Te Huang, Yi-Wen Huang, Sien-Sing Yang, Wen-Ching Huang, Hsiao-Li Chuang
Nonalcoholic fatty liver disease (NAFLD) is a serious liver disorder associated with the accumulation of fat and inflammation. The objective of this study was to determine the gut microbiota composition that might influence the progression of NAFLD. Germ-free mice were inoculated with feces from patients with nonalcoholic steatohepatitis (NASH) or from healthy persons (HL) and then fed a standard diet (STD) or high-fat diet (HFD). We found that the epididymal fat weight, hepatic steatosis, multifocal necrosis, and inflammatory cell infiltration significantly increased in the NASH-HFD group...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29101421/long-term-follow-up-of-intensive-glycaemic-control-on-renal-outcomes-in-the-veterans-affairs-diabetes-trial-vadt
#8
Lily Agrawal, Nasrin Azad, Gideon D Bahn, Ling Ge, Peter D Reaven, Rodney A Hayward, Domenic J Reda, Nicholas V Emanuele
AIMS/HYPOTHESIS: We conducted an analysis of data collected during the Veterans Affairs Diabetes Trial (VADT) and the follow-up study (VADT-F) to determine whether intensive (INT) compared with standard (STD) glycaemic control during the VADT resulted in better long-term kidney outcomes. METHODS: VADT randomly assigned 1791 veterans from 20 Veterans Affairs (VA) medical centres who had type 2 diabetes mellitus and a mean HbA1c of 9.4 ± 2% (79.2 mmol/mol) at baseline to receive either INT or STD glucose control for a median of 5...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29100765/effect-of-transosseous-tunnels-on-patella-fracture-risk-after-medial-patellofemoral-ligament-reconstruction-a-cadaveric-study
#9
Nicholas A Bonazza, Gregory S Lewis, Eric Z Lukosius, Evan P Roush, Kevin P Black, Aman Dhawan
PURPOSE: To determine whether (1) tunnels that breach the anterior cortex of the patella result in increased fracture risk and (2) transosseous tunnels drilled across the patella significantly reduce the tensile force needed to fracture the patella. METHODS: Twenty-six fresh-frozen cadaveric human patellas were randomized to 1 of 3 groups: a control group with unmodified patellas, a group with 2 transverse tunnels (TT) that did not breach the anterior cortex, and a group with 2 TT that breached the anterior cortex of the patella (PA)...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29084044/evolving-models-and-ongoing-challenges-for-hiv-pre-exposure-prophylaxis-implementation-in-the-united-states
#10
Kenneth H Mayer, Philip A Chan, Rupa Patel, Charlene A Flash, Douglas S Krakower
BACKGROUND: The use of pre-exposure prophylaxis (PrEP) for HIV prevention was approved by the FDA in 2012, but delivery to at risk persons has lagged. This critical review analyzes the current state of PrEP implementation in the US, by reviewing barriers, and innovative solutions, to enhanced PrEP access and uptake. SETTING: Clinical care settings, public health progrlams and community-based organizations (CBOs). METHODS: Critical review of recent peer-reviewed literature...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29073790/efficacy-of-dehydroepiandrosterone-dhea-supplementation-for-in-vitro-fertilization-and-embryo-transfer-cycles-a-systematic-review-and-meta-analysis
#11
Yaofang Liu, Lina Hu, Lingye Fan, Fang Wang
Dehydroepiandrosterone (DHEA) supplementation might hold some promise in vitro fertilization and embryo transfer cycles. However, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy of DHEA in patients for in vitro fertilization. PubMed, EMbase, Web of science, EBSCO and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of DHEA versus placebo on in vitro fertilization were included. Two investigators independently searched articles, extracted data and assessed the quality of included studies...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29073129/receipt-of-selected-preventive-health-services-for-women-and-men-of-reproductive-age-united-states-2011-2013
#12
Karen Pazol, Cheryl L Robbins, Lindsey I Black, Katherine A Ahrens, Kimberly Daniels, Anjani Chandra, Anjel Vahratian, Lorrie E Gavin
PROBLEM/CONDITION: Receipt of key preventive health services among women and men of reproductive age (i.e., 15-44 years) can help them achieve their desired number and spacing of healthy children and improve their overall health. The 2014 publication Providing Quality Family Planning Services: Recommendations of CDC and the U.S. Office of Population Affairs (QFP) establishes standards for providing a core set of preventive services to promote these goals. These services include contraceptive care for persons seeking to prevent or delay pregnancy, pregnancy testing and counseling, basic infertility services for those seeking to achieve pregnancy, sexually transmitted disease (STD) services, and other preconception care and related preventive health services...
October 27, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29068980/efficacy-of-dexmedetomidine-for-pain-management-in-knee-arthroscopy-a-systematic-review-and-meta-analysis
#13
REVIEW
Chen Li, Ji Qu
BACKGROUND: Dexmedetomidine showed some potential in pain control in patients undergoing knee arthroscopy. We conducted a systematic review and meta-analysis to explore the efficacy of dexmedetomidine in patients undergoing knee arthroscopy. METHODS: We searched the randomized controlled trials (RCTs) assessing the effect of dexmedetomidine on knee arthroscopy in PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases. The primary outcome was pain scores...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29061385/modified-single-prolonged-stress-reduces-cocaine-self-administration-during-acquisition-regardless-of-rearing-environment
#14
Rebecca S Hofford, Mark A Prendergast, Michael T Bardo
Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration...
October 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29059881/statistical-analysis-of-the-age-dependence-of-the-normal-capnogram
#15
Rebecca J Mieloszyk, Baruch S Krauss, Diana Montagu, Gary Andolfatto, Egidio Barbi, George C Verghese, Thomas Heldt
The age dependence of the time-based capnogram from normal, healthy subjects has not been quantitatively characterized. The existence of age dependence would impact the development and operation of automated quantitative capnographic tools. Here, we quantitatively assess the relationship between normal capnogram shape and age. Capnograms were collected from healthy subjects, and physiologically-based features (exhalation duration, end-tidal CO2 and time spent at this value, normalized time spent at end-tidal CO2, end-exhalation slope, and instantaneous respiratory rate) were computationally extracted...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29056486/angiographic-assessment-of-atherosclerotic-load-at-the-lower-extremity-in-patients-with-diabetic-foot-and-charcot-neuro-arthropathy
#16
Mehmet B Çildağ, Bülent M Ertuğrul, Ömer Fk Köseoğlu, Songül Çildağ, David G Armstrong
BACKGROUND: The aim of this study was to investigate atherosclerotic load at the lower extremity in patients with diabetic foot and charcot neuro-arthropathy and compare them with patients with diabetic foot without charcot neuro-arthropathy. METHODS: This retrospective study consists of 78 patients with diabetic foot who had lower extremity angiography with antegrade approach. All patients were classified into two groups; neuro ischemic wounds with charcot neuro-arthropathy (30/78) and without charcot neuro-arthropathy (48/78)...
October 19, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29054252/methodology-on-quantification-of-sonication-duration-for-safe-application-of-mr-guided-focused-ultrasound-for-liver-tumour-ablation
#17
Senay Mihcin, Ioannis Karakitsios, Nhan Le, Jan Strehlow, Daniel Demedts, Michael Schwenke, Sabrina Haase, Tobias Preusser, Andreas Melzer
BACKGROUND AND OBJECTIVE: Magnetic Resonance Guided Focused Ultrasound (MRgFUS) for liver tumour ablation is a challenging task due to motion caused by breathing and occlusion due the ribcage between the transducer and the tumour. To overcome these challenges, a novel system for liver tumour ablation during free breathing has been designed. METHODS: The novel TRANS-FUSIMO Treatment System (TTS, EUFP7) interacts with a Magnetic Resonance (MR) scanner and a focused ultrasound transducer to sonicate to a moving target in liver...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29049164/electrocardiogram-in-patients-with-acute-inferior-myocardial-infarction-due-to-occlusion-of-circumflex-artery
#18
Qun Li, De-Zhao Wang, Bu-Xing Chen
To investigate the diagnostic value of electrocardiographic (ECG) ST-segment in acute inferior myocardial infarction (AIMI) caused by the left circumflex branch (LCX).A total of 240 clinical cases with AIMI in our hospital were retrospectively analyzed. All of them had received percutaneous coronary intervention (PCI) within 12 hours after symptom onset. The clinical features, ECG manifestations, and coronary artery lesion characteristics of the patients were collected.The right coronary artery (RCA) was shown to be the infarct-related artery (IRA) in 177 patients, while LCX was responsible for AIMI in 63 cases...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047622/shock-related-effects-on-aero-optical-environment-for-hemisphere-on-cylinder-turrets-at-transonic-speeds
#19
Jacob Morrida, Stanislav Gordeyev, Nicholas De Lucca, Eric J Jumper
The aero-optical environment around a hemisphere-on-cylinder turret with both flat and conformal windows was studied experimentally in flight using the Airborne Aero-Optical Laboratory-Transonic for a range of subsonic and transonic Mach numbers between 0.5 and 0.8. Above M=0.6, the local shock appeared near the top of the turret, causing additional aero-optical distortions at side-looking angles. Using time-resolved wavefronts, instantaneous shock locations were extracted and analyzed. The mean shock location was found to be near a viewing angle, α=80  deg for both window types at M=0...
June 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047608/noise-level-estimation-of-botda-for-optimal-non-local-means-denoising
#20
Xianyang Qian, Xinhong Jia, Zinan Wang, Bin Zhang, Naitian Xue, Wei Sun, Qiheng He, Han Wu
Due to the similarity of Brillouin optical time domain analyzer (BOTDA) signals, image denoising could be utilized to remove the noise. However, the performance can be much degraded due to inaccurate noise level estimation. By numerical and experimental study, we compare the noise level estimation of three different methods for BOTDA: calculating the standard deviation (STD) of the measurements, a filter-based estimation algorithm, and a patch-based estimation algorithm proposed in this paper, which selects weak textured patches of BOTDA signal and then estimates noise level using principal component analysis (W-PCA)...
June 1, 2017: Applied Optics
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