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https://www.readbyqxmd.com/read/28932971/the-correlation-of-supraspinatus-outlet-view-with-computed-tomography-for-visualization-of-the-anterior-acromial-undersurface
#1
Viktor Feldman, Niv Marom, Meir Nyska, Eugene Kotz, Jonathan E J Koh, Vidal Barchilon
INTRODUCTION: Understanding the real shape of the undersurface of the acromion prior to acromioplasty is indispensable. Today, Supraspinatus outlet view (SSOV) is a standard view used to determine the shape of the anterior acromion. Three types of acromial undersurface were described by Bigliani and Morrison. The purpose of this study was to find out whether the real acromial type can be visualized on X-ray SSOV and compare the shape of the anterior undersurface of the acromion visualized on SSOV, with the shape revealed on 2D CT reconstructions...
September 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28927677/std-nmr-experiments-identify-a-structural-motif-with-novel-second-site-activity-against-west-nile-virus-ns2b-ns3-protease
#2
Tobias Schöne, Lena Lisbeth Grimm, Naoki Sakai, Linlin Zhang, Rolf Hilgenfeld, Thomas Peters
West Nile virus (WNV) belongs to the genus Flavivirus of the family Flaviviridae. This mosquito-borne virus that is highly pathogenic to humans has been evolving into a global threat during the past two decades. Despite many efforts, neither antiviral drugs nor vaccines are available. The viral protease NS2B-NS3(pro) is essential for viral replication, and therefore it is considered a prime drug target. However, success in the development of specific NS2B-NS3(pro) inhibitors had been moderate so far. In the search for new structural motifs with binding affinity for NS2B-NS3(pro), we have screened a fragment library, the Maybridge Ro5 library, employing saturation transfer difference (STD) NMR experiments as readout...
September 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28927313/efficacy-of-probiotic-supplement-for-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#3
Jiajia Pan, Qiangwei Pan, Yumei Chen, Hongping Zhang, Xiaodong Zheng
BACKGROUND: Probiotic supplement might be beneficial for gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the efficacy of probiotic supplement in gestational diabetes mellitus. METHODS: PubMed, Embase, Web of science, EBSCO, and Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of probiotic supplement in gestational diabetes mellitus were included...
September 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-genitalium-prevalence-and-antimicrobial-resistance-in-m-genitalium-in-denmark-norway-and-sweden-in-2016
#4
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Steczkó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new CE/IVD Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 15, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28921686/the-effects-of-dynamical-synapses-on-firing-rate-activity-a-spiking-neural-network-model
#5
Radwa Khalil, Marie Z Moftah, Ahmed A Moustafa
Accumulating evidence relates the fine-tuning of synaptic maturation and regulation of neural network activity to several key factors, including GABAA signaling and a lateral spread length between neighboring neurons (i.e. local connectivity). Furthermore, a number of studies consider Short-Term synaptic Plasticity (STP) as an essential element in the instant modification of synaptic efficacy in the neuronal network and in modulating responses to sustained ranges of external Poisson Input Frequency (IF). Nevertheless, evaluating the firing activity in response to the dynamical interaction between STP (triggered by ranges of IF), and these key parameters in vitro remains elusive...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28919833/conventional-culture-versus-nucleic-acid-amplification-tests-for-screening-of-urethral-neisseria-gonorrhea-infection-among-asymptomatic-men-who-have-sex-with-men
#6
Jiratha Budkaew, Bandit Chumworathayi, Chamsai Pientong, Tipaya Ekalaksananan
BACKGROUND: Many methods are used to detect urethral Neisseria gonorrhea (NG) infection among asymptomatic men who have sex with men (MSM). The objective of this study was to define the performance of conventional culture compared to real-time polymerase chain reaction (PCR) for diagnosis of asymptomatic urethral gonorrhea among MSM. METHODS: In this cross-sectional study, 147 clinical specimens for NG testing from asymptomatic participants were evaluated. MSM >18 years old who consented to undergo urethral swab and collection of urine samples from two clinics (one was the sexually transmitted diseases (STDs) mobile clinic and the second was the antiretroviral clinic) located in Khon Kaen, Thailand, were recruited...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28916995/effects-of-environmental-enrichment-on-self-administration-of-the-short-acting-opioid-remifentanil-in-male-rats
#7
Rebecca S Hofford, Jonathan J Chow, Joshua S Beckmann, Michael T Bardo
BACKGROUND: Opioid abuse is a major problem around the world. Identifying environmental factors that contribute to opioid abuse and addiction is necessary for decreasing this epidemic. In rodents, environmental enrichment protects against the development of low dose stimulant self-administration, but studies examining the effect of enrichment and isolation (compared to standard housing) on the development of intravenous opioid self-administration have not been conducted. The present study investigated the role of environmental enrichment on self-administration of the short-acting μ-opioid remifentanil...
September 15, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28904544/changing-beliefs-and-behaviors-related-to-sexually-transmitted-diseases-in-vulnerable-women-a-qualitative-study
#8
Zahra Boroumandfar, Masoud Kianpour, Ali Zargham, Samereh Abdoli, Katayoun Tayeri, Mehrdad Salehi, Godratollah Momeni, Farzin Khorvash
BACKGROUND: The first step in health education is awareness of the people and their acceptance to change their behavior. Therefore, the aim of this study was to investigate the effects of empowerment program towards the concept of self-care and prevention of sexually transmitted diseases (STDs) in women at risk of STDs. MATERIALS AND METHODS: The present study was conducted as a qualitative approach (step of action and observation of an action) by using conventional content analysis method...
July 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28903180/diamine-derivative-anti-trichomonas-vaginalis-and-anti-tritrichomonas-foetus-activities-by-effect-on-polyamine-metabolism
#9
Graziela Vargas Rigo, Márcia Rodrigues Trein, Danielle da Silva Trentin, Alexandre José Macedo, Bruno Assis de Oliveira, Angelina Maria de Almeida, Raquel Brandt Giordani, Mauro Vieira de Almeida, Tiana Tasca
Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28902965/mechanistic-insight-into-the-binding-of-multivalent-pyrrolidines-to-%C3%AE-mannosidases
#10
Stefania Mirabella, Giampiero D'Adamio, Camilla Matassini, Andrea Goti, Sandra Delgado, Ana Gimeno, Inmaculada Robina, Antonio J Moreno-Vargas, Sergej Šesták, Jesús Jiménez-Barbero, Francesca Cardona
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects towards jack bean α-mannosidase and a Golgi α-mannosidase from Drosophila melanogaster, as well as a good selectivity with respect to a lysosomal α-mannosidase, which is important for anticancer applications. STD NMR and molecular modeling studies supported a multivalent mechanism with specific interactions of the bioactive iminosugars with Jack bean α-mannosidase. TEM studies suggested a binding mode that involves the formation of aggregates, which result from the intermolecular cross-linked network of interactions between the multivalent inhibitors and two or more dimers of JBMan heterodimeric subunits...
August 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28899995/hiv-seroconversion-among-baltimore-city-residents-tested-at-a-mobile-van-programme
#11
Sarah Puryear, Phyllis Burnett, Kathleen R Page, Ravikiran Muvva, Patrick Chaulk, Khalil G Ghanem, Anne Monroe
BACKGROUND: Many individuals with HIV in the USA are unaware of their diagnosis, and therefore cannot be engaged in treatment services, have worse clinical outcomes and are more likely to transmit HIV to others. Mobile van testing may increase HIV testing and diagnosis. Our objective was to characterise risk factors for HIV seroconversion among individuals using mobile van testing. METHODS: A case cohort study (n=543) was conducted within an HIV surveillance dataset of mobile van testing users with at least two HIV tests between September 2004 and August 2009 in Baltimore, Maryland...
September 12, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28899911/correlation-of-end-tidal-carbon-dioxide-amplitude-spectrum-area-and-coronary-perfusion-pressure-in-a-porcine-model-of-cardiac-arrest
#12
Nicolas Segal, Anja K Metzger, Johanna C Moore, Laura India, Michael C Lick, Paul S Berger, Wanchun Tang, David G Benditt, Keith G Lurie
Amplitude Spectrum Area (AMSA) values during ventricular fibrillation (VF) correlate with myocardial energy stores and predict defibrillation success. By contrast, end tidal CO2 (ETCO2) values provide a noninvasive assessment of coronary perfusion pressure and myocardial perfusion during cardiopulmonary resuscitation (CPR). Given the importance of the timing of defibrillation shock delivery on clinical outcome, we tested the hypothesis that AMSA and ETCO2 correlate with each other and can be used interchangably to correlate with myocardial perfusion in an animal laboratory preclinical, randomized, prospective investigation...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28894220/binding-modes-of-environmental-endocrine-disruptors-to-human-serum-albumin-insights-from-std-nmr-itc-spectroscopic-and-molecular-docking-studies
#13
Hongqin Yang, Yanmei Huang, Jiuyang Liu, Peixiao Tang, Qiaomei Sun, Xinnuo Xiong, Bin Tang, Jiawei He, Hui Li
Given that bisphenols have an endocrine-disrupting effect on human bodies, thoroughly exposing their potential effects at the molecular level is important. Saturation transfer difference (STD) NMR-based binding studies were performed to investigate the binding potential of two bisphenol representatives, namely, bisphenol B (BPB) and bisphenol E (BPE), toward human serum albumin (HSA). The relative STD (%) suggested that BPB and BPE show similar binding modes and orientations, in which the phenolic rings were spatially close to HSA binding site...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893492/rural-counties-chlamydia-and-gonorrhea-rates-in-pennsylvania-among-adolescents-and-young-adults
#14
Casey N Pinto, Lorah D Dorn, Vernon M Chinchilli, Ping Du, Guangqing Chi
BACKGROUND: American adolescents and young adults between the ages of 15 and 24 account for 50% of all sexually transmitted diseases (STDs) annually. Rural populations in this age group are often understudied, despite having factors that place them at higher risk for STDs. PURPOSE: The purpose of this study was to evaluate the utility of time series analysis in the assessment of rural Pennsylvania county-level chlamydia and gonorrhea rates overtime (2004-2014) for 15- to 19- and 20- to 24-year-old age groups by gender...
August 24, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28886262/effectiveness-of-antibiotic-treatment-in-infertile-patients-with-sterile-leukocytospermia-induced-by-tobacco-use
#15
Bogdan Pajovic, Ljiljana Pajovic, Marko Vukovic
Our study investigated whether antibiotic therapy in infertile tobacco users with sterile leukocytospermia and a history of former sexual transmitted disease (STD) has an advantage over cessation of smoking alone. For this study, 80 male infertile smokers were divided into two subgroups. The first group numbered 40 patients treated with a two week course of doxycycline, 100 mg, twice daily, while the second group simply ceased smoking. A control group of 20 patients with chronic abacterial prostatitis (CPPS III a) were treated with the same antibiotic for two weeks...
September 8, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28882681/provider-communication-with-adolescent-and-young-females-during-sexual-and-reproductive-health-visits-findings-from-the-2011-2015-national-survey-of-family-growth
#16
Nicole Liddon, Riley J Steiner, Gladys M Martinez
OBJECTIVE: National guidelines advise providers to counsel patients about contraception and condom use during sexual and reproductive health care visits. This study assesses provider communication with adolescent and young women about birth control, emergency contraception, and condoms during such visits. STUDY DESIGN: Using data from sexually active 15-24year old women participating in the 2011-2015 National Survey of Family Growth, we examined prevalence of provider communication about birth control, emergency contraception and condoms when receiving other sexual and reproductive health services in the past year...
September 4, 2017: Contraception
https://www.readbyqxmd.com/read/28880917/analysis-of-hiv-prevalence-among-pregnant-women-in-liangshan-prefecture-china-from-2009-to-2015
#17
Shujuan Yang, Chao Yang, Qiang Liao, Wenwen Zhai, Gang Yu, Lin Xiao, Qixing Wang, Yuhan Gong, Suhua Zhang, Yongna Yao, Ke Wang, Ju Wang, Shaochao Bian, Qian Liu
BACKGROUND: Yi people make up about 50% of the population in Liangshan Prefecture, Sichuan Province, China, but accounted for 88.07% of new HIV cases in the prefecture from 2011 to 2013. This study evaluated HIV prevalence in pregnant women of Liangshan Prefecture using HIV sentinel surveillance (HSS) data over the period of 2009 to 2015. METHODS: Xichang, Zhaojue County, and Butuo County were selected as HSS sites. We investigated the temporal trends in HIV prevalence in these areas, and the association between demographic and behavioral characteristics and risk of HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28876320/understanding-the-effects-of-forced-sex-on-sexually-transmitted-disease-acquisition-and-sexually-transmitted-disease-care-findings-from-the-national-survey-of-family-growth-2011-2013
#18
Kathryn A Brookmeyer, Oscar Beltran, Neetu Abad
BACKGROUND: Although there is evidence for heightened sexually transmitted disease (STD) acquisition among women who experienced sexual violence, little is known about their patterns of STD testing, STD diagnosis, and STD treatment. METHODS: Data was drawn from cycle eight of the National Survey of Family Growth (2011-2013). Logistic regression analyses used SUDAAN to examine the link between forced sex and risky sexual behavior as well as forced sex and STD testing, diagnoses, treatment, and connection to care...
June 17, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876317/cervical-cancer-screening-and-prevention-in-78-sexually-transmitted-disease-clinics-united-states-2014-2015
#19
Emily McGinnis, Beth E Meyerson, Elissa Meites, Mona Saraiya, Rebecca Griesse, Emily Snoek, Laura Haderxhanaj, Lauri E Markowitz, William Smith
BACKGROUND: Human papillomavirus (HPV) infections cause approximately 30,700 cancers annually among US men and women, cervical cancer being the most common. Human papillomavirus vaccination is recommended routinely for US girls and boys at age 11 to 12 years, and for those not previously vaccinated, through age 26 and 21 years for women and men, respectively. Our objective was to assess current cervical cancer screening and HPV vaccination practices among sexually transmitted disease (STD) clinics in the United States...
June 19, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876297/what-s-in-a-name-perceptions-of-the-terms-sexually-transmitted-disease-and-sexually-transmitted-infection-among-late-adolescents
#20
Alyssa M Lederer, Elizabeth E Laing
BACKGROUND: There has been a shift from using the term sexually transmitted disease (STD) to sexually transmitted infection (STI), primarily based on conjecture that STI is less stigmatizing. However, there is a dearth of evidence regarding how the public actually perceives these terms. METHODS: Students at a Midwestern university participated in an online survey and were randomized to the open-ended question "What comes to mind when you think of the term sexually transmitted disease (STD)?" (n = 205) or "What comes to mind when you think of the term sexually transmitted infection (STI)?" (n = 208)...
July 31, 2017: Sexually Transmitted Diseases
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