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https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#1
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166707/-establishment-of-myocardial-targeted-nanoparticles-and-preliminary-evaluation-of-its-effects-on-prevention-and-treatment-of-myocardial-injury
#2
Y Y Liu, C Wang, P F Luo, Z F Xia
Objective: To establish 3-{4-[2-hydroxyl-(1-methylethylamino) propoxy] phenyl} propionic acid cetylesters (PAC) modified nanoparticles, and preliminarily explore its cardiomyocyte-targeting function and protection effects on myocardium. Methods: (1) HL-1 myocardial cells were divided into cyanidin-3 (Cy3) marked non-targeted small interference RNA (Cy3-siNC) group and Cy3 marked small interference RNA designed for the nuclear factor kappa B (NF-κB)-p65 gene (Cy3-si435) group according to the random number table, with 3 wells in each group...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29165577/quantitative-mri-brain-in-congenital-adrenal-hyperplasia-in-vivo-assessment-of-the-cognitive-and-structural-impact-of-steroid-hormones
#3
Emma A Webb, Lucy Elliott, Dominic Carlin, Martin Wilson, Kirsty Hall, Jennifer Netherton, Julie Reed, Tim G Barrett, Vijay Salwani, Jon D Clayden, Wiebke Arlt, Nils Krone, Andrew C Peet, Amanda G Wood
Context: Brain white matter hyper-intensities are seen on routine clinical imaging in 46% of adults with congenital adrenal hyperplasia (CAH). The extent and functional relevance of these abnormalities have not been studied using quantitative MRI analysis. Objective: To examine white matter microstructure, neural volumes and CNS metabolites in CAH due to 21-hydroxylase deficiency (21OHD) and to determine whether identified abnormalities are associated with cognition, glucocorticoid and androgen exposure...
November 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165397/low-computational-cost-footprint-deformities-diagnosis-sensor-through-angles-dimensions-analysis-and-image-processing-techniques
#4
J Rodolfo Maestre-Rendon, Tomas A Rivera-Roman, Juan M Sierra-Hernandez, Ivan Cruz-Aceves, Luis M Contreras-Medina, Carlos Duarte-Galvan, Arturo A Fernandez-Jaramillo
Manual measurements of foot anthropometry can lead to errors since this task involves the experience of the specialist who performs them, resulting in different subjective measures from the same footprint. Moreover, some of the diagnoses that are given to classify a footprint deformity are based on a qualitative interpretation by the physician; there is no quantitative interpretation of the footprint. The importance of providing a correct and accurate diagnosis lies in the need to ensure that an appropriate treatment is provided for the improvement of the patient without risking his or her health...
November 22, 2017: Sensors
https://www.readbyqxmd.com/read/29163955/extra-osseous-99m-tc-methylene-diphosphonate-uptake-detected-enlargement-of-the-knee-joint-in-patient-with-polyarthritis
#5
Maria Grazia Caprio, Mariarosaria Manganelli, Simona Limone, Massimiliano Sorbillo, Mario Quarantelli, Alberto Cuocolo, Ciro Gabriele Mainolfi
Bone scintigraphy is a nuclear scanning test used to find abnormalities in the skeleton. Certain abnormal processes involving soft tissues can also cause skeletal accumulation of radiotracer during bone scintigraphy. We present a case of periarticular knee soft tissue (99m)Tc methylene diphosphonate uptake in a patient with asymmetric polyarthritis. A 33-year-old patient with asymmetric polyarthritis, skin lesions and joint pain underwent bone scintigraphy. Total body examination showed an extra-osseous uptake in periarticular soft tissue of knees joints...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29163946/vertebral-body-segmentation-with-growcut-initial-experience-workflow-and-practical-application
#6
Jan Egger, Christopher Nimsky, Xiaojun Chen
Objectives: Spinal diseases are very common; for example, the risk of osteoporotic fracture is 40% for White women and 13% for White men in the United States during their lifetime. Hence, the total number of surgical spinal treatments is on the rise with the aging population, and accurate diagnosis is of great importance to avoid complications and a reappearance of the symptoms. Imaging and analysis of a vertebral column is an exhausting task that can lead to wrong interpretations. The overall goal of this contribution is to study a cellular automata-based approach for the segmentation of vertebral bodies between the compacta and surrounding structures yielding to time savings and reducing interpretation errors...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163410/modeling-reveals-the-role-of-aging-and-glucose-uptake-impairment-in-l1a1-listeria-monocytogenes-biofilm-life-cycle
#7
Eva Balsa-Canto, Carlos Vilas, Alejandro López-Núñez, Maruxa Mosquera-Fernández, Romain Briandet, Marta L Cabo, Carlos Vázquez
Listeria monocytogenes is a food-borne pathogen that can persist in food processing plants by forming biofilms on abiotic surfaces. The benefits that bacteria can gain from living in a biofilm, i.e., protection from environmental factors and tolerance to biocides, have been linked to the biofilm structure. Different L. monocytogenes strains build biofilms with diverse structures, and the underlying mechanisms for that diversity are not yet fully known. This work combines quantitative image analysis, cell counts, nutrient uptake data and mathematical modeling to provide a mechanistic insight into the dynamics of the structure of biofilms formed by L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163384/bacillus-subtilis-biofilm-development-a-computerized-study-of-morphology-and-kinetics
#8
Sarah Gingichashvili, Danielle Duanis-Assaf, Moshe Shemesh, John D B Featherstone, Osnat Feuerstein, Doron Steinberg
Biofilm is commonly defined as accumulation of microbes, embedded in a self-secreted extra-cellular matrix, on solid surfaces or liquid interfaces. In this study, we analyze several aspects of Bacillus subtilis biofilm formation using tools from the field of image processing. Specifically, we characterize the growth kinetics and morphological features of B. subtilis colony type biofilm formation and compare these in colonies grown on two different types of solid media. Additionally, we propose a model for assessing B...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163140/simultaneous-imaging-of-cerebrovascular-structure-and-function-in-hypertensive-rats-using-synchrotron-radiation-angiography
#9
Liping Wang, Zhihao Mu, Xiaojie Lin, Jieli Geng, Ti Qiao Xiao, Zhijun Zhang, Yongting Wang, Yongjing Guan, Guo-Yuan Yang
Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dynamic changes of vascular structure in hypertensive rats using novel synchrotron radiation angiography. Twenty-four spontaneously hypertensive rats (SHR) and 24 Sprague-Dawley (SD) rats underwent synchrotron radiation (SR) angiography...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29163092/how-well-can-saliency-models-predict-fixation-selection-in-scenes-beyond-central-bias-a-new-approach-to-model-evaluation-using-generalized-linear-mixed-models
#10
Antje Nuthmann, Wolfgang Einhäuser, Immo Schütz
Since the turn of the millennium, a large number of computational models of visual salience have been put forward. How best to evaluate a given model's ability to predict where human observers fixate in images of real-world scenes remains an open research question. Assessing the role of spatial biases is a challenging issue; this is particularly true when we consider the tendency for high-salience items to appear in the image center, combined with a tendency to look straight ahead ("central bias"). This problem is further exacerbated in the context of model comparisons, because some-but not all-models implicitly or explicitly incorporate a center preference to improve performance...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29163087/localized-fluctuant-oscillatory-activity-by-working-memory-load-a-simultaneous-eeg-fmri-study
#11
Xiaojie Zhao, Xiaoyun Li, Li Yao
Working memory (WM) is a resource-limited memory system for temporary storage and processing of brain information during the execution of cognitive tasks. Increased WM load will increase the amount and difficulty of memory information. Several studies have used electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) to explore load-dependent cognition processing according to the time courses of electrophysiological activity or the spatial pattern of blood oxygen metabolic activity. However, the relationships between these two activities and the underlying neural mechanism are still unclear...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29163021/schizophrenia-shows-disrupted-links-between-brain-volume-and-dynamic-functional-connectivity
#12
Anees Abrol, Barnaly Rashid, Srinivas Rachakonda, Eswar Damaraju, Vince D Calhoun
Studies featuring multimodal neuroimaging data fusion for understanding brain function and structure, or disease characterization, leverage the partial information available in each of the modalities to reveal data variations not exhibited through the independent analyses. Similar to other complex syndromes, the characteristic brain abnormalities in schizophrenia may be better understood with the help of the additional information conveyed by leveraging an advanced modeling method involving multiple modalities...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29163017/electrical-neuroimaging-of-music-processing-reveals-mid-latency-changes-with-level-of-musical-expertise
#13
Clara E James, Mathias S Oechslin, Christoph M Michel, Michael De Pretto
This original research focused on the effect of musical training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in gray and white matter, and higher order brain functioning using (f)MRI [(functional) Magnetic Resonance Imaging], as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29162881/discrimination-of-crispr-cas9-induced-mutants-of-rice-seeds-using-near-infrared-hyperspectral-imaging
#14
Xuping Feng, Cheng Peng, Yue Chen, Xiaodan Liu, Xujun Feng, Yong He
Identifying individuals with target mutant phenotypes is a significant procedure in mutant exploitation for implementing genome editing technology in a crop breeding programme. In the present study, a rapid and non-invasive method was proposed to identify CRISPR/Cas9-induced rice mutants from their acceptor lines (huaidao-1 and nanjing46) using hyperspectral imaging in the near-infrared (NIR) range (874.41-1733.91 nm) combined with chemometric analysis. The hyperspectral imaging data were analysed using principal component analysis (PCA) for exploratory purposes, and a support vector machine (SVM) and an extreme learning machine (ELM) were applied to build discrimination models for classification...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162445/the-neuromorphological-caudate-putaminal-clustering-of-neostriate-interneurons-kohonen-self-organizing-maps-and-supervised-artificial-neural-networks-with-multivariate-analysis
#15
Ivan Grbatinić, Nebojša Milošević, Bojana Krstonošić
AIMS: The objective of this study is to investigate the possibility of the neuromorphotopological clustering of neostriate interneurons (NSIN) and their consequent classification into caudate (CIN) and putaminal neuron type (PIN), according to the nuclear localization of the neurons. It tends to discover whether these two topological neuron types are morphologically different. MATERIAL AND METHODS: The binary images of adult human NSIN are used for the purposes of the analysis...
November 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29161645/the-impact-of-domestic-violence-exposure-on-south-asian-children-in-the-united-states-perspectives-of-domestic-violence-agency-staff
#16
Maya I Ragavan, Tsion Fikre, Uma Millner, Megan Bair-Merritt
The South Asian community is the fastest growing ethnic group in the United States, and past research suggests that South Asian domestic violence (DV) survivors may require culturally-specific resources. Similarly, South Asian children in the US exposed to DV may have unique responses and needs, but this has not been explored to date. The objective of this study was to examine the specific needs of South Asian children exposed to DV from the vantage point of staff from South Asian DV agencies across the United States...
November 18, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29160812/micro-droplet-detection-method-for-measuring-the-concentration-of-alkaline-phosphatase-labeled-nanoparticles-in-fluorescence-microscopy
#17
Rufeng Li, Yibei Wang, Hong Xu, Baowei Fei, Binjie Qin
This paper developed and evaluated a quantitative image analysis method to measure the concentration of the nanoparticles on which alkaline phosphatase (AP) was immobilized. These AP-labeled nanoparticles are widely used as signal markers for tagging biomolecules at nanometer and sub-nanometer scales. The AP-labeled nanoparticle concentration measurement can then be directly used to quantitatively analyze the biomolecular concentration. Micro-droplets are mono-dispersed micro-reactors that can be used to encapsulate and detect AP-labeled nanoparticles...
November 21, 2017: Sensors
https://www.readbyqxmd.com/read/29160744/modulation-of-neural-oscillatory-activity-during-dynamic-face-processing
#18
Elaine Foley, Gina Rippon, Carl Senior
Various neuroimaging and neurophysiological methods have been used to examine neural activation patterns in response to faces. However, much of previous research has relied on static images of faces, which do not allow a complete description of the temporal structure of face-specific neural activities to be made. More recently, insights are emerging from fMRI studies about the neural substrates that underpin our perception of naturalistic dynamic face stimuli, but the temporal and spectral oscillatory activity associated with processing dynamic faces has yet to be fully characterized...
November 21, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29159048/resting-state-connectivity-and-executive-functions-after-pediatric-arterial-ischemic-stroke
#19
Salome Kornfeld, Rui Yuan, Bharat B Biswal, Sebastian Grunt, Sandeep Kamal, Juan Antonio Delgado Rodríguez, Mária Regényi, Roland Wiest, Christian Weisstanner, Claus Kiefer, Maja Steinlin, Regula Everts
Background: The aim of this study was to compare the relationship between core executive functions and frontoparietal network connections at rest between children who had suffered an arterial ischemic stroke and typically developing peers. Methods: Children diagnosed with arterial ischemic stroke more than two years previously and typically developing controls were included. Executive function (EF) measures comprised inhibition (Go-NoGo task), fluency (category fluency task), processing speed (processing speed tasks), divided attention, working memory (letter-number sequencing), conceptual reasoning (matrices) and EF in everyday life (questionnaire)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29158448/executive-function-declines-in-the-first-6-months-after-a-transient-ischemic-attack-or-transient-neurological-attack
#20
Frank G van Rooij, Nicole O Plaizier, Sarah E Vermeer, Bozena M Góraj, Peter J Koudstaal, Edo Richard, Frank-Erik de Leeuw, Roy P C Kessels, Ewoud J van Dijk
BACKGROUND AND PURPOSE: Although by definition transient, both transient ischemic attack (TIA) and transient neurological attack (TNA) are associated with cognitive impairment. Determinants and course of cognitive function afterward are, however, unclear. We prospectively determined cognitive performance after TIA and TNA in relation to clinical diagnosis and diffusion-weighted imaging (DWI) results. METHODS: TIA and TNA patients aged ≥45 years without prior stroke or dementia underwent comprehensive cognitive assessment and magnetic resonance imaging within 7 days after the qualifying event...
November 20, 2017: Stroke; a Journal of Cerebral Circulation
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