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https://www.readbyqxmd.com/read/28918257/pathways-of-the-inferior-frontal-occipital-fasciculus-in-overt-speech-and-reading
#1
Claire Rollans, Kulpreet Cheema, George K Georgiou, Jacqueline Cummine
In this study, we examined the relationship between tractography-based measures of white matter integrity (ex. fractional anisotropy [FA]) from diffusion tensor imaging (DTI) and five reading-related tasks, including rapid automatized naming (RAN) of letters, digits, and objects, and reading of real words and nonwords. Twenty university students with no reported history of reading difficulties were tested on all five tasks and their performance was correlated with diffusion measures extracted through DTI tractography...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28918110/emergent-behaviors-in-rbcs-flows-in-micro-channels-using-digital-particle-image-velocimetry
#2
F Cairone, D Ortiz, P J Cabrales, M Intaglietta, M Bucolo
The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, however their introduction, also, for pathological conditions diagnosis would be important in different biomedical contexts. To overcome this lack is necessary to establish the relation between the RBCs flow and blood viscosity changes in micro-vessels...
September 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28917880/intercalated-chitosan-hydroxyapatite-nanocomposites-promising-materials-for-bone-tissue-engineering-applications
#3
Muhammad Anwaar Nazeer, Emel Yilgör, Iskender Yilgör
Preparation and characterization of chitosan/hydroxyapatite (CS/HA) nanocomposites displaying an intercalated structure is reported. Hydroxyapatite was synthesized through sol-gel process. Formic acid was introduced as a new solvent to obtain stable dispersions of nano-sized HA particles in polymer solution. CS/HA dispersions with HA contents of 5, 10 and 20% by weight were prepared. Self-assembling of HA nanoparticles during the drying of the solvent cast films led to the formation of homogeneous CS/HA nanocomposites...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917753/nuclear-forensics-investigation-of-morphological-signatures-in-the-thermal-decomposition-of-uranyl-peroxide
#4
Ian J Schwerdt, Adam Olsen, Robert Lusk, Sean Heffernan, Michael Klosterman, Bryce Collins, Sean Martinson, Trenton Kirkham, Luther W McDonald
The analytical techniques typically utilized in a nuclear forensic investigation often provide limited information regarding the process history and production conditions of interdicted nuclear material. In this study, scanning electron microscopy (SEM) analysis of the surface morphology of amorphous-UO3 samples calcined at 250, 300, 350, 400, and 450°C from uranyl peroxide was performed to determine if the morphology was indicative of the synthesis route and thermal history for the samples. Thermogravimetic analysis-mass spectrometry (TGA-MS) and differential scanning calorimetry (DSC) were used to correlate transitions in the calcined material to morphological transformations...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917696/brain-mapping-in-multiple-sclerosis-lessons-learned-about-the-human-brain
#5
REVIEW
Massimo Filippi, Paolo Preziosa, Maria A Rocca
The application of structural and functional magnetic resonance imaging (MRI) techniques in patients with multiple sclerosis (MS) has certainly helped to improve our understanding of the mechanisms responsible for clinical disability and cognitive impairment in this condition. The numerous studies performed in MS patients have also provided many lessons on the structure-function relationships in the human brain, which could be applied to healthy subjects and to patients affected by other neurological conditions...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917669/knowledge-driven-computational-modeling-in-alzheimer-s-research-current-state-and-future-trends
#6
Hugo Geerts, Martin Hofmann-Apitius, Thomas J Anastasio
Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels have been identified. The sheer number of putative hypotheses makes it almost impossible to estimate their contribution to the clinical outcome and to develop a comprehensive view on the pathological processes driving the clinical phenotype...
September 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28917264/expression-of-kisspeptin-protein-in-hypothalamus-and-lh-profile-of-growing-female-lambs
#7
Jolanta Polkowska, Anna Wójcik-Gładysz, Natalia Chmielewska, Marta Wańkowska
Kisspeptin (kp) is considered to be one of the major regulators of the induction of pubertal events via the activation of the gonadotrophin-releasing hormone-LH system. The aim of the present study was to analyse expression of immunoreactive (ir) kp in the hypothalamic neurons of female lambs from the neonatal to the peripubertal period (5 days to 32 weeks) in relation to the plasma LH pattern using immunohistochemistry and image analysis. Hypothalami were collected from female lambs (n=33) from the infantile, juvenile, prepubertal and peripubertal periods...
September 18, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28916806/rewiring-of-neuronal-networks-during-synaptic-silencing
#8
Jana Katharina Wrosch, Vicky von Einem, Katharina Breininger, Marc Dahlmanns, Andreas Maier, Johannes Kornhuber, Teja Wolfgang Groemer
Analyzing the connectivity of neuronal networks, based on functional brain imaging data, has yielded new insight into brain circuitry, bringing functional and effective networks into the focus of interest for understanding complex neurological and psychiatric disorders. However, the analysis of network changes, based on the activity of individual neurons, is hindered by the lack of suitable meaningful and reproducible methodologies. Here, we used calcium imaging, statistical spike time analysis and a powerful classification model to reconstruct effective networks of primary rat hippocampal neurons in vitro...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916622/quantification-and-determination-of-normal-123-i-meta-iodobenzylguanidine-heart-to-mediastinum-ratio-hmr-from-cardiac-spect-ct-and-correlation-with-planar-hmr
#9
Raza Alvi, Edward J Miller, Taraneh Hashemi Zonouz, Veronica Sandoval, Noor Tariq, Rachel Lampert, Albert J Sinusas, Yi-Hwa Liu
Assessment of cardiac (123)I-mIBG uptake relies on the heart-to-mediastinal ratio (HMR) derived from planar images. We have developed novel semi-automated quantitative methodologies for assessing HMR from single photon emission computed tomography (SPECT) images using a dedicated cardiac multi-pinhole SPECT/computerized tomography (CT) system and determined the lower limit of normal (LLN) SPECT-derived HMR and the correlation to planar-derived HMR. Methods: Twenty-one healthy volunteers were injected with (123)I-meta Iodobenzylguanidine ((123)I-mIBG) and imaged using two different cameras...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28916243/feasibility-and-accuracy-of-automated-software-for-transthoracic-three-dimensional-left-ventricular-volume-and-function-analysis-comparisons-with-two-dimensional-echocardiography-three-dimensional-transthoracic-manual-method-and-cardiac-magnetic-resonance-imaging
#10
Gloria Tamborini, Concetta Piazzese, Roberto M Lang, Manuela Muratori, Elisa Chiorino, Massimo Mapelli, Laura Fusini, Sarah Ghulam Ali, Paola Gripari, Gianluca Pontone, Daniele Andreini, Mauro Pepi
BACKGROUND: Recently, a new automated software package (HeartModel) was developed to obtain three-dimensional (3D) left ventricular (LV) volumes using a model-based algorithm (MBA) with a "one-button" simple system and user-adjustable slider. The aims of this study were to verify the feasibility and accuracy of the MBA in comparison with other commonly used imaging techniques in a large unselected population, to evaluate possible accuracy improvements of free operator border adjustments or changes of the slider's default position, and to identify differences in method accuracy related to specific pathologies...
September 12, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28915935/secondary-ion-mass-spectrometry-the-application-in-the-analysis-of-atmospheric-particulate-matter
#11
REVIEW
Di Huang, Xin Hua, Guang-Li Xiu, Yong-Jie Zheng, Xiao-Ying Yu, Yi-Tao Long
Currently, considerable attention has been paid to atmospheric particulate matter (PM) investigation due to its importance in human health and global climate change. Surface characterization, single particle analysis and depth profiling of PM is important for a better understanding of its formation processes and predicting its impact on the environment and human being. Secondary ion mass spectrometry (SIMS) is a surface technique with high surface sensitivity, high spatial resolution chemical imaging and unique depth profiling capabilities...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915791/segmentation-and-classification-of-two-channel-c-elegans-nucleus-labeled-fluorescence-images
#12
Mengdi Zhao, Jie An, Haiwen Li, Jiazhi Zhang, Shang-Tong Li, Xue-Mei Li, Meng-Qiu Dong, Heng Mao, Louis Tao
BACKGROUND: Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research, and this calls for an automatic image processing method that is suitable for both normal and abnormal structures. RESULTS: Our image processing method consists of nuclear segmentation, feature extraction and classification...
September 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28915543/effects-of-diisononyl-phthalate-on-danio-rerio-reproduction
#13
Stefania Santangeli, Francesca Maradonna, Maya Zanardini, Valentina Notarstefano, Giorgia Gioacchini, Isabel Forner-Piquer, Hamid Habibi, Oliana Carnevali
Di-isononyl phthalate (DiNP) is a high molecular weight phthalate commonly used as a plasticizer. It was introduced as a replacement for bis (2-ethylhexyl) phthalate (DEHP) which is used in the production of plasticized polyvinyl chloride (PVC). The purpose of this study was to investigate for the first time the effect of DiNP on female reproductive physiology in Danio rerio. Fish were exposed to five different doses of DiNP plus control (0 μg/L; 0.42 μg/L; 4.2 μg/L; 42 μg/L; 420 μg/L; 4200 μg/L) for a period of 21 days...
September 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28915318/applications-of-high-resolution-magic-angle-spinning-mrs-in-biomedical-studies-ii-human-diseases
#14
REVIEW
Christopher Dietz, Felix Ehret, Francesco Palmas, Lindsey A Vandergrift, Yanni Jiang, Vanessa Schmitt, Vera Dufner, Piet Habbel, Johannes Nowak, Leo L Cheng
High-resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high-resolution spectra of non-liquid biological samples, while preserving tissue architecture for subsequent histopathological analysis, the technique has become invaluable for biochemical and biomedical studies. Using HRMAS MRS, alterations in measured metabolites, metabolic ratios, and metabolomic profiles present the possibility to improve identification and prognostication of various diseases and decipher the metabolomic impact of drug therapies...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28915276/relationship-between-rectus-abdominis-muscle-thickness-and-metabolic-syndrome-in-middle-aged-men
#15
Eun Sil Choi, Soo Hyun Cho, Jung-Ha Kim
BACKGROUND AND OBJECTIVE: Skeletal muscle has been suggested as an important factor in the pathophysiology of metabolic syndrome. During the aging process, muscle mass is lost in specific body parts. However, few studies have investigated the relationship between site-specific muscle loss assessed using computed tomography (CT) and metabolic syndrome. This study was conducted to investigate the association between metabolic syndrome and rectus abdominis muscle thickness at the umbilicus level (RAM), which reflects site-specific muscle loss of the abdomen using CT image...
2017: PloS One
https://www.readbyqxmd.com/read/28914994/hessian-based-quantitative-image-analysis-of-host-pathogen-confrontation-assays
#16
Zoltan Cseresnyes, Kaswara Kraibooj, Marc Thilo Figge
Host-fungus interactions have gained a lot of interest in the past few decades, mainly due to an increasing number of fungal infections that are often associated with a high mortality rate in the absence of effective therapies. These interactions can be studied at the genetic level or at the functional level via imaging. Here, we introduce a new image processing method that quantifies the interaction between host cells and fungal invaders, for example, alveolar macrophages and the conidia of Aspergillus fumigatus...
September 15, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28914613/a-novel-system-for-commissioning-brachytherapy-applicators-example-of-a-ring-applicator
#17
Gabriel Paiva Fonseca, Michiel R van den Bosch, Robert Voncken, Mark Podesta, Frank Verhaegen
A novel system was developed to improve commissioning and quality assurance of brachytherapy applicators used in High Dose Rate (HDR). It employs an imaging panel to create reference images and to measure dwell times and dwell positions. As an example: two ring applicators of the same model were evaluated. An applicator was placed on the surface of an imaging panel and a HDR 192Ir source was positioned in an imaging channel above the panel to generate an image of the applicator, using the gamma photons of the brachytherapy source...
September 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28913893/gonial-angle-measured-by-orthopantomography-as-a-predictor-of-maximum-occlusal-force
#18
Shunta Miwa, Masahiro Wada, Shumei Murakami, Tohru Suganami, Kazunori Ikebe, Yoshinobu Maeda
PURPOSE: To establish the accuracy of measuring the gonial angle on an orthopantomogram (GAO), as defined by the anatomic relationship between the inferior and posterior borders of the mandible. Furthermore, to examine the relationship between GAO and maximum occlusal force (MOF) in the premolar and molar regions of healthy young adults. MATERIALS AND METHODS: Orthopantomograms of dry mandibles were obtained in three orientations in the sagittal plane, to represent variation in image acquisition in clinical settings...
September 15, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28913742/automated-morphological-and-morphometric-analysis-of-mass-spectrometry-imaging-data-application-to-biomarker-discovery
#19
Gaël Picard de Muller, Rima Ait-Belkacem, David Bonnel, Rémi Longuespée, Jonathan Stauber
Mass spectrometry imaging datasets are mostly analyzed in terms of average intensity in regions of interest. However, biological tissues have different morphologies with several sizes, shapes, and structures. The important biological information, contained in this highly heterogeneous cellular organization, could be hidden by analyzing the average intensities. Finding an analytical process of morphology would help to find such information, describe tissue model, and support identification of biomarkers. This study describes an informatics approach for the extraction and identification of mass spectrometry image features and its application to sample analysis and modeling...
September 14, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28913699/morphological-analysis-of-the-filamentous-fungus-penicillium-chrysogenum-using-flow-cytometry-the-fast-alternative-to-microscopic-image-analysis
#20
Daniela Ehgartner, Christoph Herwig, Jens Fricke
An important parameter in filamentous bioreactor cultivations is the morphology of the fungi, due to its interlink to productivity and its dependency on process conditions. Filamentous fungi show a large variety of morphological forms in submerged cultures. These range from dispersed hyphae, to interwoven mycelial aggregates, to denser hyphal aggregates, the so-called pellets. Depending on the objective function of the bioprocess, different characteristics of the morphology are favorable and need to be quantified accurately...
September 14, 2017: Applied Microbiology and Biotechnology
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