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https://www.readbyqxmd.com/read/28738651/recent-advances-in-sample-pre-treatment-for-emerging-methods-in-proteomic-analysis
#1
María Ramos-Payán, Juan A Ocaña-González, Rut M Fernández-Torres, Santiago Maspoch, Miguel Ángel Bello-López
The objective of proteomics is the study of proteins (including their structure elucidation, the characterization of their role in biochemical process, the detection and identification of anomalous modifications in their structures and behavior, etc.) from both a qualitative and quantitative point of view. These studies have to face several difficulties as (a) the intrinsic complexity of protein molecules, (b) the low concentrations of the studied proteins, (c) the complexity of the biological samples (which could lead to interferences from the components of these matrixes), etc...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737699/efficient-retrieval-of-massive-ocean-remote-sensing-images-via-a-cloud-based-mean-shift-algorithm
#2
Mengzhao Yang, Wei Song, Haibin Mei
The rapid development of remote sensing (RS) technology has resulted in the proliferation of high-resolution images. There are challenges involved in not only storing large volumes of RS images but also in rapidly retrieving the images for ocean disaster analysis such as for storm surges and typhoon warnings. In this paper, we present an efficient retrieval of massive ocean RS images via a Cloud-based mean-shift algorithm. Distributed construction method via the pyramid model is proposed based on the maximum hierarchical layer algorithm and used to realize efficient storage structure of RS images on the Cloud platform...
July 23, 2017: Sensors
https://www.readbyqxmd.com/read/28737295/towards-a-unified-analysis-of-brain-maturation-and-aging-across-the-entire-lifespan-a-mri-analysis
#3
Pierrick Coupé, Gwenaelle Catheline, Enrique Lanuza, José Vicente Manjón
There is no consensus in literature about lifespan brain maturation and senescence, mainly because previous lifespan studies have been performed on restricted age periods and/or with a limited number of scans, making results instable and their comparison very difficult. Moreover, the use of nonharmonized tools and different volumetric measurements lead to a great discrepancy in reported results. Thanks to the new paradigm of BigData sharing in neuroimaging and the last advances in image processing enabling to process baby as well as elderly scans with the same tool, new insights on brain maturation and aging can be obtained...
July 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28736474/phenotype-analysis-of-early-risk-factors-from-electronic-medical-records-improves-image-derived-diagnostic-classifiers-for-optic-nerve-pathology
#4
Shikha Chaganti, Kunal P Nabar, Katrina M Nelson, Louise A Mawn, Bennett A Landman
We examine imaging and electronic medical records (EMR) of 588 subjects over five major disease groups that affect optic nerve function. An objective evaluation of the role of imaging and EMR data in diagnosis of these conditions would improve understanding of these diseases and help in early intervention. We developed an automated image-processing pipeline that identifies the orbital structures within the human eyes from computed tomography (CT) scans, calculates structural size, and performs volume measurements...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28736473/theoretical-and-empirical-comparison-of-big-data-image-processing-with-apache-hadoop-and-sun-grid-engine
#5
Shunxing Bao, Frederick D Weitendorf, Andrew J Plassard, Yuankai Huo, Aniruddha Gokhale, Bennett A Landman
The field of big data is generally concerned with the scale of processing at which traditional computational paradigms break down. In medical imaging, traditional large scale processing uses a cluster computer that combines a group of workstation nodes into a functional unit that is controlled by a job scheduler. Typically, a shared-storage network file system (NFS) is used to host imaging data. However, data transfer from storage to processing nodes can saturate network bandwidth when data is frequently uploaded/retrieved from the NFS, e...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28736430/a-case-of-type-1-autoimmune-pancreatitis-aip-a-form-of-igg4-related-disease-igg4-rd
#6
Mounira El Euch, Souha Hddad, Madiha Mahfoudhi, Hela Maktouf, Fethi Ben Hamida, Fatima Jaziri, Khaoula Ben Abdelghani, Sami Turki, Taïeb Ben Abdallah
BACKGROUND Type 1 autoimmune pancreatitis (AIP), also known as lymphoplasmacytic sclerosing pancreatitis (LPSP), is a rare cause of chronic pancreatitis, characterized by a fibro-inflammatory process. However, patients with AIP may have a good response to corticosteroid therapy. We describe a Tunisian patient with AIP that was confirmed to be an IgG4-related disease (IgG4-RD). CASE REPORT We describe a case of a 70-year-old man who was admitted to hospital for obstructive jaundice and abdominal pain. Serum liver function tests were abnormal and upper abdominal computed tomography (CT) imaging showed diffuse pancreatic swelling and strictures of the main pancreatic duct without any focal lesion...
July 24, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28735094/dedicated-tool-to-assess-the-impact-of-a-rhetorical-task-on-human-body-temperature
#7
Robert Koprowski, Sławomir Wilczyński, Katarzyna Martowska, Dominik Gołuch, Emilia Wrocławska-Warchala
Functional infrared thermal imaging is a method widely used in medicine, including analysis of the mechanisms related to the effect of emotions on physiological processes. The article shows how the body temperature may change during stress associated with performing a rhetorical task and proposes new parameters useful for dynamic thermal imaging measurements MATERIALS AND METHODS: 29 healthy male subjects were examined. They were given a rhetorical task that induced stress. Analysis and processing of collected body temperature data in a spatial resolution of 256×512pixels and a temperature resolution of 0...
July 19, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28734525/classification-of-cardiovascular-tissues-using-lbp-based-descriptors-and-a-cascade-svm
#8
Claudia Mazo, Enrique Alegre, Maria Trujillo
BACKGROUND AND OBJECTIVE: Histological images have characteristics, such as texture, shape, colour and spatial structure, that permit the differentiation of each fundamental tissue and organ. Texture is one of the most discriminative features. The automatic classification of tissues and organs based on histology images is an open problem, due to the lack of automatic solutions when treating tissues without pathologies. METHOD: In this paper, we demonstrate that it is possible to automatically classify cardiovascular tissues using texture information and Support Vector Machines (SVM)...
August 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28733863/population-level-coordination-of-pigment-response-in-individual-cyanobacterial-cells-under-altered-nitrogen-levels
#9
Jaclyn Murton, Aparna Nagarajan, Amelia Y Nguyen, Michelle Liberton, Harmony A Hancock, Himadri B Pakrasi, Jerilyn A Timlin
Cyanobacterial phycobilisome (PBS) pigment-protein complexes harvest light and transfer the energy to reaction centers. Previous ensemble studies have shown that cyanobacteria respond to changes in nutrient availability by modifying the structure of PBS complexes, but this process has not been visualized for individual pigments at the single-cell level due to spectral overlap. We characterized the response of four key photosynthetic pigments to nitrogen depletion and repletion at the subcellular level in individual, live Synechocystis sp...
July 21, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28733358/pattern-analyses-reveal-separate-experience-based-fear-memories-in-the-human-right-amygdala
#10
Senne Braem, Jan De Houwer, Jelle Demanet, Kenneth S L Yuen, Raffael Kalisch, Marcel Brass
Learning fear via the experience of contingencies between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) is often assumed to be fundamentally different from learning fear via instructions. An open question is whether fear-related brain areas respond differently to experienced CS-US contingencies than to merely instructed CS-US contingencies. Here, we contrasted two experimental conditions where subjects were instructed to expect the same CS-US contingencies while only one condition was characterized by prior experience with the CS-US contingency...
July 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28732991/in-situ-observation-of-ultrasonic-cavitation-induced-fragmentation-of-the-primary-crystals-formed-in-al-alloys
#11
Feng Wang, Iakovos Tzanakis, Dmitry Eskin, Jiawei Mi, Thomas Connolley
The cavitation-induced fragmentation of primary crystals formed in Al alloys were investigated for the first time by high-speed imaging using a novel experimental approach. Three representative primary crystal types, Al3Ti, Si and Al3V with different morphologies and mechanical properties were first extracted by deep etching of the corresponding Al alloys and then subjected to ultrasonic cavitation processing in distilled water. The dynamic interaction between the cavitation bubbles and primary crystals was imaged in situ and in real time...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732976/preparation-of-waterborne-dispersions-of-epoxy-resin-by-ultrasonic-assisted-supercritical-co2-nanoemulsification-technique
#12
Hanyang Gao, Guoxin Hu, Kun Liu, Liqun Wu
Waterborne nanoemulsion of diglycidyl ether of bisphenol A type epoxy resin (DGEBA) with droplet size of around 124nm was prepared by using an ultrasonic-assisted supercritical carbon dioxide (scCO2) technique in an autoclave reactor at a low temperature (32°C). A view cell positioned in-line with the ultrasonic probe allowed observation of the emulsification process. From the image analysis and droplet size measurement, the influence mechanisms of the ultrasonic power, the degree of mixing of scCO2 with DGEBA, the adding amount of emulsifier, and the system pressure on emulsification process and emulsion droplet size were investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28730955/itraq-based-proteomic-analysis-of-appsw-ind-mice-provides-insights-into-the-early-changes-in-alzheimer-s-disease
#13
Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-Hong Luo, Junyu Xu
BACKGROUND: Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse models. However, biomarkers for presymptom diagnosis of AD are still under investigation, as are the presymptom molecular changes in AD pathogenesis. OBJECTIVE: In this study, we aim to analyzed the early proteomic changes in APPSw,Ind mice and to conduct further functional studies on interesting proteins...
July 19, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28730740/statistical-process-control-and-verifying-positional-accuracy-of-a-cobra-motion-couch-using-step-wedge-quality-assurance-tool
#14
Diana Binny, Craig M Lancaster, Jamie V Trapp, Scott B Crowe
This study utilizes process control techniques to identify action limits for TomoTherapy couch positioning quality assurance tests. A test was introduced to monitor accuracy of the applied couch offset detection in the TomoTherapy Hi-Art treatment system using the TQA "Step-Wedge Helical" module and MVCT detector. Individual X-charts, process capability (cp), probability (P), and acceptability (cpk) indices were used to monitor a 4-year couch IEC offset data to detect systematic and random errors in the couch positional accuracy for different action levels...
July 21, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28730182/tracking-deceased-related-thinking-with-neural-pattern-decoding-of-a-cortical-basal-ganglia-circuit
#15
Noam Schneck, Stefan Haufe, Tao Tu, George A Bonanno, Kevin Ochsner, Paul Sajda, J John Mann
BACKGROUND: Deceased-related thinking is central to grieving and potentially critical to processing of the loss. Self-report measurements might fail to capture important elements of deceased-related thinking and processing. Here, we used a machine learning approach applied to fMRI - known as neural decoding - to develop a measure of ongoing deceased-related processing. METHODS: 23 subjects grieving the loss of a first-degree relative, spouse or partner within 14 months underwent two fMRI tasks...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28729834/white-matter-hyperintensity-in-elderly-patients-with-diabetes-mellitus-is-associated-with-cognitive-impairment-functional-disability-and-a-high-glycoalbumin-glycohemoglobin-ratio
#16
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki
Aims: Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment of activities of daily living (ADL), the clinical relevance of WMH in elderly patients with diabetes mellitus (DM) is not still clear. The aim of this study was to examine whether WMH volume is associated with ADL and cognitive function and whether glucose control and glucose variability can affect WMH volume in these patients. Methods: This cross-sectional study investigated the associations of WMH with cognitive function and instrumental ADL (IADL), as well as metabolic and vascular risk factors in a total of 178 elderly patients with diabetes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28728097/nonlinear-modulation-of-interacting-between-comt-and-depression-on-brain-function
#17
L Gong, C He, Y Yin, Q Ye, F Bai, Y Yuan, H Zhang, L Lv, H Zhang, Z Zhang, C Xie
BACKGROUND: The catechol-O-methyltransferase (COMT) gene is related to dopamine degradation and has been suggested to be involved in the pathogenesis of major depressive disorder (MDD). However, how this gene affects brain function properties in MDD is still unclear. METHODS: Fifty patients with MDD and 35 cognitively normal participants underwent a resting-state functional magnetic resonance imaging scan. A voxelwise and data-drive global functional connectivity density (gFCD) analysis was used to investigate the main effects and the interactions of disease states and COMT rs4680 gene polymorphism on brain function...
June 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28727443/plasmonic-thermal-decomposition-digestion-of-proteins-a-rapid-on-surface-protein-digestion-technique-for-mass-spectrometry-imaging
#18
Rong Zhou, Franco Basile
A method based on plasmon surface resonance absorption and heating was developed to perform a rapid on-surface protein thermal decomposition and digestion suitable for imaging MS and/or profiling. This photo-thermal process or plasmonic thermal decomposition/digestion (plasmonic-TDD) method incorporates a continuous wave (CW) laser excitation and gold nanoparticles (Au-NPs) to induce known thermal decomposition reactions that cleave peptides and proteins specifically at the C-terminus of aspartic acid and at the N-terminus of cysteine...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28724752/the-fluid-mechanics-of-transcatheter-heart-valve-leaflet-thrombosis-in-the-neo-sinus
#19
Prem A Midha, Vrishank Raghav, Rahul Sharma, Jose F Condado, Ikechukwu U Okafor, Tanya Rami, Gautam Kumar, Vinod H Thourani, Hasan Jilaihawi, Vasilis Babaliaros, Raj R Makkar, Ajit P Yoganathan
Background -Transcatheter heart valve (THV) thrombosis has been increasingly reported. In these studies, thrombus quantification has been based on 2D assessment of a 3D phenomenon. Methods -Post-procedural four-dimensional, volume-rendered CT (4DCT) data of CoreValve, Evolut R, and SAPIEN 3 transcatheter aortic valve replacement (TAVR) patients enrolled in the RESOLVE trial were included in this analysis. Patients on anticoagulation were excluded. SAPIEN 3 and CoreValve/Evolut R patients with and without hypo-attenuated leaflet thickening (HALT) were included in order to study differences between groups...
July 19, 2017: Circulation
https://www.readbyqxmd.com/read/28724223/chromium-vi-adsorption-from-wastewater-using-porous-magnetite-nanoparticles-prepared-from-titanium-residue-by-a-novel-solid-phase-reduction-method
#20
Genkuan Ren, Xinlong Wang, Penghui Huang, Benhe Zhong, Zhiye Zhang, Lin Yang, Xiushan Yang
Porous magnetite nanoparticles were successfully synthesized by reduction of titanium residue with pyrite under nitrogen protection, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, vibrating sample magnetometer, X-ray photoelectron spectroscope, zeta potential and Brunauer-Emmett-Teller method. The XRD analysis confirmed the formation of porous magnetite nanoparticles with single spinel structure. The SEM image demonstrated that porous magnetite nanoparticles displayed spherical shape with the average diameter of ~51nm...
July 13, 2017: Science of the Total Environment
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