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pneumonia statin

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https://www.readbyqxmd.com/read/28974587/statin-therapy-in-patients-with-community-acquired-pneumonia
#1
Frances S Grudzinska, Davinder Ps Dosanjh, Dhruv Parekh, Rachel Ca Dancer, Jaimin Patel, Peter Nightingale, Georgia M Walton, Elizabeth Sapey, David R Thickett
Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. There is evidence of an association between improved survival from infection and statin use. The possible beneficial effects of statins are complicated by the common use of macrolide antibiotics for pneumonia, with current guidance suggesting that concurrent macrolide and statin use is contraindicated.We conducted an observational study of statin use in patients with CAP. Of 2,067 patients with CAP, 30.4% were on statin therapy at admission...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28657793/pulmonary-infections-in-the-elderly-lead-to-impaired-neutrophil-targeting-improved-by-simvastatin
#2
Elizabeth Sapey, Jaimin M Patel, Hannah L Greenwood, Georgia M Walton, Jon Hazeldine, Charendeep Sadhra, Dhruv Parekh, Rachel Ca Dancer, Peter Nightingale, Janet M Lord, David R Thickett
RATIONALE: Dysregulated neutrophil functions are described with age and sepsis. Statins are associated with improved infection survival in some observational studies but trials in critically ill patients have not shown benefit. Statins also alter neutrophil responses in vitro. OBJECTIVE: To assess neutrophil migratory accuracy with age during respiratory infections and determine if and how a statin intervention could alter these blunted responses. METHODS: Migratory accuracy of blood neutrophils from young (aged<35) and old (aged>60) patients in health, during a lower respiratory tract infection (LRTI), pneumonia (CAP) and pneumonia associated sepsis (S-CAP) was assessed with and without simvastatin...
June 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28639080/the-use-of-statins-and-risk-of-community-acquired-pneumonia
#3
REVIEW
Mohammed A Batais, Abdur Rahman Khan, Aref A Bin Abdulhak
PURPOSE OF THE REVIEW: Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from this review is to discuss the epidemiology of CAP, and role of statins as adjunctive therapy in the development of CAP. RECENT FINDINGS: Statins are lipid-lowering medications characterized by their ability to control hypercholesterolemia in addition to other pleiotropic effects that could explain their role in the pathogenesis of CAP...
August 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28469499/a-case-of-statin-associated-autoimmune-myopathy
#4
Alexander J Sweidan, Anthony Leung, Cassandra J Kaiser, Sarah J Strube, Andrei N Dokukin, Stephen Romansky, Sassan Farjami
A 70-year-old previously independent man developed progressive proximal leg weakness resulting in a fall at home suffering traumatic brain injury. He was prescribed a statin medication two years prior, but this was discontinued on admission to the hospital due to concern for statin myopathy. His weakness continued to progress while in acute rehabilitation, along with the development of dysphagia requiring placement of gastrostomy tube and respiratory failure requiring tracheostomy. Corticosteroids and intravenous immunoglobulin were administered without response...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28450174/atorvastatin-as-a-promising-anticryptococcal-agent
#5
Noelly de Queiroz Ribeiro, Marliete Carvalho Costa, Thaís Furtado Ferreira Magalhães, Hellem Cristina Silva Carneiro, Lorena Vívien Oliveira, Alide Caroline Lima Fontes, Julliana Ribeiro Alves Santos, Gabriela Freitas Ferreira, Glauber Ribeiro de Sousa Araujo, Vinícius Alves, Susana Frases, Tatiane Alves Paixão, Maria Aparecida de Resende Stoianoff, Daniel Assis Santos
Cryptococcosis caused by Cryptococcus gattii leads to pneumonia and meningoencephalitis, and has a high mortality rate worldwide due to the inadequacy of available therapy and increasing drug resistance. There is a need to develop effective treatments, and drug repositioning is an interesting alternative to achieve new strategies to treat cryptococcosis. Atorvastatin (ATO), a statin currently used to treat hypercholesterolaemia, was tested in this study as an adjuvant to control infections caused by C. gattii...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28357403/effect-of-prior-atorvastatin-treatment-on-the-frequency-of-hospital-acquired-pneumonia-and-evolution-of-biomarkers-in-patients-with-acute-ischemic-stroke-a-multicenter-prospective-study
#6
Yuetian Yu, Cheng Zhu, Chunyan Liu, Yuan Gao
Objective. To investigate whether prior treatment of atorvastatin reduces the frequency of hospital acquired pneumonia (HAP). Methods. Totally, 492 patients with acute ischemic stroke and Glasgow Coma Scale ≤ 8 were enrolled in this study. Subjects were assigned to prior atorvastatin treatment group (n = 268, PG) and no prior treatment group (n = 224, NG). All the patients were given 20 mg atorvastatin every night during their hospital stay. HAP frequency and 28-day mortality were measured. Levels of inflammatory biomarkers [white blood cell (WBC), procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6)] were tested...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28238924/postoperative-infections-are-associated-with-increased-risk-of-cardiac-events-in-vascular-patients
#7
Tristen T Chun, Manuel Garcia-Toca, James F Eng, Jeffrey Slaiby, Edward J Marcaccio, William G Cioffi, Daithi S Heffernan
BACKGROUND: Despite advances in perioperative care, the rate of cardiac events in vascular patients remains high. We have previously shown that infections in trauma patients are associated with higher rates of subsequent cardiac complications, likely due to the additive effect of a second hit of an infection following the trauma. The aim of this study was to investigate whether there is an association between postoperative infections and subsequent cardiac events in vascular patients...
May 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28207437/lack-of-association-between-preoperative-statin-use-and-respiratory-and-neurologic-complications-after-cardiac-surgery
#8
Ryu Komatsu, Huseyin Oguz Yilmaz, Jing You, C Allen Bashour, Shobana Rajan, Edward G Soltesz, Daniel I Sessler, Alparslan Turan
BACKGROUND: Statins may reduce the risk of pulmonary and neurologic complications after cardiac surgery. METHODS: The authors acquired data for adults who had coronary artery bypass graft, valve surgery, or combined procedures. The authors matched patients who took statins preoperatively to patients who did not. First, the authors assessed the association between preoperative statin use and the primary outcomes of prolonged ventilation (more than 24 h), pneumonia (positive cultures of sputum, transtracheal fluid, bronchial washings, and/or clinical findings consistent with the diagnosis of pneumonia), and in-hospital all-cause mortality, using logistic regressions...
May 2017: Anesthesiology
https://www.readbyqxmd.com/read/28148539/dtb-select-2-february-2017
#9
(no author information available yet)
MHRA clarifies spironolactone advice ● Statin dosing: morning or evening? ● PPI use and risk of community-acquired pneumonia ● Non-inferiority trials: caution needed ● CV safety of celecoxib? ● ADRs and emergency department visits ● Study questions use of duloxetine in stress incontinence ● New oral anticoagulants: more on GI bleeding risk.
February 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28051279/carotid-intima-media-thickness-and-blood-biomarkers-of-atherosclerosis-in-patients-after-stroke-or-myocardial-infarction
#10
Iwona Kurkowska-Jastrzebska, Michał A Karlinski, Beata Błazejewska-Hyzorek, Iwona Sarzynska-Dlugosz, Krzysztof J Filipiak, Anna Czlonkowska
AIM: To test if circulating levels of markers of inflammation, endothelial function, and chronic infections, as well as association between these markers and carotid intima media thickness (CIMT), depend on the stage of atherosclerosis expressed as a history of a major vascular event. METHODS: The associations were analyzed separately in 75 healthy controls, 79 patients 3-6 months after the first-ever non-cardioembolic ischemic stroke (IS), and 37 patients 3-6 months after the first-ever myocardial infarction (MI)...
December 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27960215/nonantibiotic-adjunctive-therapies-for-community-acquired-pneumonia-corticosteroids-and-beyond-where-are-we-with-them
#11
Oriol Sibila, Ana Rodrigo-Troyano, Antoni Torres
Community-acquired pneumonia (CAP) is a leading cause of hospitalization, morbidity, and mortality. Despite advances in antibiotic treatments, mortality among patients with CAP is still high. For this reason, interest has been focused on nonantibiotic therapeutic measures directed to the host response rather than the microorganism. The development of an efficacious adjunctive treatment has important implications for reducing mortality in CAP. Some clinical studies performed in the last decade have shown a clinically beneficial effect of corticosteroids, possibly by diminishing local and systemic inflammatory host response...
December 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27943383/statin-potency-and-the-risk-of-hospitalization-for-community-acquired-pneumonia
#12
Ju-Young Shin, Maria Eberg, Pierre Ernst, Kristian B Filion
AIM: Previous studies suggest that statins may have beneficial respiratory effects. However, it is unclear if these purported benefits vary with statin potency. Our objective was to determine if higher potency statins, compared with lower potency statins, were associated with a reduced risk of hospitalization for community-acquired pneumonia (HCAP). METHODS: We conducted a nested case-control analysis of a retrospective, population-based cohort of new users of statins using data extracted from the UK's Clinical Practice Research Datalink and Hospital Episode Statistics...
June 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27942512/treating-the-host-response-to-emerging-virus-diseases-lessons-learned-from-sepsis-pneumonia-influenza-and-ebola
#13
REVIEW
David S Fedson
There is an ongoing threat of epidemic or pandemic diseases that could be caused by influenza, Ebola or other emerging viruses. It will be difficult and costly to develop new drugs that target each of these viruses. Statins and angiotensin receptor blockers (ARBs) have been effective in treating patients with sepsis, pneumonia and influenza, and a statin/ARB combination appeared to dramatically reduce mortality during the recent Ebola outbreak. These drugs target (among other things) the endothelial dysfunction found in all of these diseases...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27922256/statins-in-critical-care-to-give-or-not-to-give
#14
Amr S Omar, Samy Hanoura, Haifa M Aljanubi, Ahmed Mahfouz
Owing to statin's immune modulatory, anti-inflammatory, antioxidant, antithrombotic and endothelial function actions, they are widely used in the critical care settings in diverse disease scenarios. We aim to explore the evidence to globalize the utilization of statins in the intensive care practice for different indications. We carried out a search of the PubMed, Cochrane and EMBASE databases up to January 2016. We included review articles, meta-analyses, and original trials on the effects of statin therapy in the intensive care unit (ICU) combining the following MESH terms: 'satins', 'intensive care, 'cardiac surgery', 'sepsis', 'acute respiratory distress syndrome' 'pneumonia', subarachnoid hemorrhage', traumatic brain injury and 'critical illness'...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27788932/causes-and-predictors-of-death-in-patients-with-coronary-heart-disease-from-the-heart-and-soul-study
#15
Elizabeth Y Wang, Jeffrey Dixson, Nelson B Schiller, Mary A Whooley
Although the prevalence of coronary heart disease (CHD) in the United States has increased during the past 25 years, cardiovascular mortality has decreased due to advances in CHD therapy and prevention. We sought to determine the proportion of patients with CHD who die from cardiovascular versus noncardiovascular causes and the causes and predictors of death, in a cohort of patients with CHD. The Heart and Soul Study enrolled 1,024 participants with stable CHD from 2000 to 2002 and followed them for 10 years...
January 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27720881/bronchiectasis-severity-is-an-independent-risk-factor-for-vascular-disease-in-a-bronchiectasis-cohort
#16
Ieuan Edward Shepherd Evans, Pallavi Bedi, Tom M Quinn, Adam T Hill
BACKGROUND: Interest in the association of vascular disease with COPD and pneumonia has increased, but there is a lack of research in this area with patients with bronchiectasis. METHODS: A retrospective study of 400 patients attending a specialist bronchiectasis clinic in NHS Lothian (Edinburgh, UK) between May 2013 and September 2014 was conducted. The study assessed the prevalence of vascular disease (ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and atrial fibrillation)...
February 2017: Chest
https://www.readbyqxmd.com/read/27686457/the-effect-of-statins-on-influenza-like-illness-morbidity-and-mortality
#17
Paul Brassard, Jennifer W Wu, Pierre Ernst, Sophie Dell'Aniello, Brielan Smiechowski, Samy Suissa
PURPOSE: The effect of statins on cytokine-mediated inflammatory responses may impact on the prognosis of influenza. We assessed whether statin use decreases the incidence of adverse influenza-related outcomes. Additionally, we used a new-user study design to minimize healthy user bias. We further examined the possibility of non-causal associations by using unrelated outcomes. METHODS: We used the UK Clinical Practice Research Datalink to identify all patients aged 30 or older diagnosed with influenza-like illness during 1997-2010...
January 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27583588/community-acquired-pneumonia-still-a-major-burden-of-disease
#18
Charles Feldman, Ronald Anderson
PURPOSE OF REVIEW: Describe recent studies that may impact on the management of community-acquired pneumonia (CAP). RECENT FINDINGS: CAP continues to be associated with a considerable burden of disease. Diagnosis remains problematic, and various biomarkers are neither accurate in the diagnosis of the presence of CAP nor superior to standard severity of illness scores in predicting outcome. Current evidence indicates that patients with nonsevere CAP can be effectively treated with antibiotic monotherapy, whereas those with severe infection, particularly ICU cases, do best with early initiation of combination antibiotic therapy...
October 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27403321/statins-and-morbidity-and-mortality-in-copd-in-the-comic-study-a-prospective-copd-cohort-study
#19
Emanuel Citgez, Job van der Palen, Kirsten Koehorst-Ter Huurne, Kris Movig, Paul van der Valk, Marjolein Brusse-Keizer
BACKGROUND: Both chronic inflammation and cardiovascular comorbidity play an important role in the morbidity and mortality of patients with chronic obstructive pulmonary disease (COPD). Statins could be a potential adjunct therapy. The additional effects of statins in COPD are, however, still under discussion. The aim of this study is to further investigate the association of statin use with clinical outcomes in a well-described COPD cohort. METHODS: 795 patients of the Cohort of Mortality and Inflammation in COPD (COMIC) study were divided into statin users or not...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27220368/impact-of-hospitalization-for-acute-myocardial-infarction-on-adherence-to-statins-among-older-adults
#20
Ian M Kronish, Joseph S Ross, Hong Zhao, Paul Muntner
BACKGROUND: Little is known about the impact of hospitalization for an acute myocardial infarction (AMI) on subsequent adherence to statins. METHODS AND RESULTS: Using administrative claims from a 5% random sample of Medicare beneficiaries, we identified a cohort of Medicare patients aged ≥65 years, hospitalized from 2007 to 2011, taking statins in the year before AMI hospitalization (n=6618). We then determined the proportion of patients nonadherent to statins (proportion of days covered <80%) in the year before AMI hospitalization who became statin adherent (proportion of days covered ≥80%) in the year after AMI hospitalization...
July 2016: Circulation. Cardiovascular Quality and Outcomes
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