keyword
MENU ▼
Read by QxMD icon Read
search

radioactive iodine avidity

keyword
https://www.readbyqxmd.com/read/29688947/impact-of-patient-age-and-histological-type-on-radioactive-iodine-avidity-of-recurrent-lesions-of-differentiated-thyroid-carcinoma
#1
Kenichi Nakanishi, Toyone Kikumori, Noriyuki Miyajima, Yuko Takano, Sumiyo Noda, Dai Takeuchi, Shingo Iwano, Yasuhiro Kodera
BACKGROUND: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC...
July 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29511992/major-reduction-in-axillary-lymph-node-dissections-after-neoadjuvant-systemic-therapy-for-node-positive-breast-cancer-by-combining-pet-ct-and-the-mari-procedure
#2
M E M van der Noordaa, F H van Duijnhoven, M E Straver, E J Groen, M Stokkel, C E Loo, P H M Elkhuizen, N S Russell, M T F D Vrancken Peeters
BACKGROUND: Axillary lymph node dissection (ALND) is frequently performed for node-positive (cN+) breast cancer patients. Combining positron emission tomography/computed tomography (PET/CT) before-NST and the MARI (marking axillary lymph nodes with radioactive iodine seeds) procedure after neoadjuvant systemic therapy (NST) has the potential for avoiding unnecessary ALNDs. This report presents the results from implementation of this strategy. METHODS: All breast cancer patients treated with NST at the Netherlands Cancer Institute who underwent a PET/CT and the MARI procedure from July 2014 to July 2017 were included in the study...
June 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29467951/reverting-iodine-avidity-of-radioactive-iodine-refractory-thyroid-cancer-with-a-new-tyrosine-kinase-inhibitor-k905-0266-excavated-by-high-throughput-nis-sodium-iodide-symporter-enhancer-screening-platform-using-dual-reporter-gene-system
#3
Ji Min Oh, Senthilkumar Kalimuthu, Prakash Gangadaran, Se Hwan Baek, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Chae Moon Hong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Radioactive-iodine (RAI) therapy is typically unprevailing as anaplastic thyroid cancer (ATC) management, owing to the decrease in the endogenous sodium iodide symporter (NIS) expression. Therefore, new strategies for NIS re-induction are required to improve the efficacy of RAI therapy in ATC. In this study, we developed a novel high-throughput NIS enhancer screening platform using a dual reporter gene system to identify a potent tyrosine kinase inhibitor (TKI) and selected a new hit compound, K905-0266 TKI...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413688/predictive-factors-of-outcome-in-poorly-differentiated-thyroid-carcinomas
#4
Christelle de la Fouchardière, Myriam Decaussin-Petrucci, Julien Berthiller, Françoise Descotes, Jonathan Lopez, Jean-Christophe Lifante, Jean-Louis Peix, Anne-Laure Giraudet, Armelle Delahaye, Sandrine Masson, Claire Bournaud-Salinas, Françoise Borson Chazot
BACKGROUND: The prognosis of poorly differentiated thyroid carcinomas (PDTC) is heterogeneous though generally poor. The objectives of this study were to identify clinical and molecular factors of poor prognosis. METHODS: One hundred four consecutive patients treated for a PDTC between 01/01/2000 and 31/12/2010 were included in this study. A pathological review was done for all cases (blinded to clinical data and outcome). RESULTS: All patients underwent thyroidectomy...
March 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29144798/pancreas-metastases-from-papillary-thyroid-carcinoma-a-review-of-the-literature
#5
REVIEW
Maja Davidson, Randall J Olsen, April A Ewton, Richard J Robbins
OBJECTIVE: Although locoregional metastases occur in 5 to 10% of patients with papillary thyroid cancer (PTC), distant metastases are rare, especially to the pancreas. Here we review the literature regarding metastases to the pancreas from PTC and present an illustrative patient. METHODS: The literature search was performed through using the PubMed database. The information regarding our illustrative case was obtained from the medical records of our institution...
December 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28972676/prognostic-indicators-of-outcomes-in-patients-with-lung-metastases-from-differentiated-thyroid-carcinoma-during-long-term-follow-up
#6
Seo Young Sohn, Hye In Kim, Young Nam Kim, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
BACKGROUND: Distant metastases, although uncommon, represent maximum disease-related mortality in differentiated thyroid carcinoma (DTC). Lungs are the most frequent sites of metastases. We aimed to evaluate long-term outcomes and identify prognostic factors in metastatic DTC limited to the lungs. METHODS: This retrospective study included 89 patients with DTC and metastases limited to the lungs, who were treated between 1996 and 2012 at Samsung Medical Center. Progression-free survival (PFS) and cancer-specific survival (CSS) rates were evaluated according to clinicopathologic factors...
February 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#7
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel H Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
BACKGROUND: The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve (131)I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. METHODS: A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post injection of (123)I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
November 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28801060/prognostic-markers-in-well-differentiated-papillary-and-follicular-thyroid-cancer-wdtc
#8
REVIEW
S L Gillanders, J P O'Neill
OBJECTIVES: WDTC (papillary and follicular thyroid cancer) make up around 90% of all thyroid tumours. Overall, the prognosis in patients with WDTC is excellent. However, there are small cohorts of patients who experience a more aggressive form of disease which is often associated with certain poor prognostic factors. Identifying these patients at an early stage is imperative for guiding treatment decisions. With recent developments in this area we plan to discuss the current evidence surrounding prognostic markers...
March 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28693291/diagnostic-clue-of-nodular-fasciitis-mimicking-metastasis-in-papillary-thyroid-cancer-mismatching-findings-on-18-f-fdg-pet-ct-and-123-i-whole-body-scan-a-case-report
#9
Minjung Seo, Misung Kim, Eun Sook Kim, Hongbo Sim, Sungmin Jun, Seol Hoon Park
This study reports a case of nodular fasciitis incidentally detected in a patient with papillary thyroid cancer. A 47-year-old woman underwent a total thyroidectomy and radioactive iodine therapy for papillary thyroid cancer. On a follow-up fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) scan after 12 months, a focal (18)F-FDG-avid lesion was incidentally detected in the paraspinal muscle. It was well-enhanced on CT and magnetic resonance imaging, indicating metastasis. However, the lesion was not iodine avid on the (123)I whole body scan, which favored benign etiology over metastasis from thyroid cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28524246/combined-pet-ct-and-axillary-lymph-node-marking-with-radioactive-iodine-seeds-mari-procedure-for-tailored-axillary-treatment-in-node-positive-breast-cancer-after-neoadjuvant-therapy
#10
B B Koolen, M Donker, M E Straver, M E M van der Noordaa, E J T Rutgers, R A Valdés Olmos, M J T F D Vrancken Peeters
BACKGROUND: The treatment of axillary lymph node metastases after neoadjuvant systemic therapy (NST) remains debatable and axillary lymph node dissection (ALND) is still the standard of care. Marking axillary lymph nodes with radioactive iodine seeds (MARI procedure) is accurate in restaging the axilla after NST (false-negative rate 7 per cent). Here, the potential of tailored axillary treatment, determined by combining the results of PET-CT before NST with those of the MARI procedure after NST, was analysed...
August 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28510122/anti-thyroglobulin-antibodies-do-not-significantly-increase-the-risk-of-finding-iodine-avid-metastases-on-post-radioactive-iodine-ablation-scan-in-low-risk-thyroid-cancer-patients
#11
F Nabhan, K Porter, L Senter, M D Ringel
OBJECTIVE: Post-operative thyroglobulin (Tg) levels can predict the likelihood of residual cancer, including distant metastases, thereby influencing postsurgical treatment strategies even in patients with low-risk disease. Circulating anti-thyroglobulin antibodies (anti-Tg Abs) interfere with Tg measurement preventing this clinical use. It is not known if the presence of anti-Tg Abs predicts metastatic disease on post-therapy scan in patients with low-risk disease or if they should influence the use or dose of I-131 therapy...
September 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28489758/analysis-of-radioiodine-therapy-and-prognostic-factors-of-differentiated-thyroid-cancer-patients-with-pulmonary-metastasis-an-8-year-retrospective-study
#12
Renfei Wang, Yueqian Zhang, Jian Tan, Guizhi Zhang, Ruiguo Zhang, Wei Zheng, Yajing He
To assess the efficacy of radioiodine therapy (RIT) and investigate the prognostic factors for patients with pulmonary metastasis secondary to differentiated thyroid carcinoma (DTC) through a retrospective study. A total of 80 patients with radioactive iodine-131 (I)-avid pulmonary metastasis from DTC treated with I from 2007 to 2014 at our institution entered the study. Treatment response was mainly measured by two parameters: serum thyroglobulin (Tg) levels and post-therapeutic I whole-body scan (WBS). Treatment variables were assessed for statistical significance using the univariate and multivariate analyses...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27853381/h%C3%A3-rthle-cell-carcinoma-current-perspectives
#13
REVIEW
Sara Ahmadi, Michael Stang, Xiaoyin Sara Jiang, Julie Ann Sosa
Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27750021/initial-size-of-metastatic-lesions-is-best-prognostic-factor-in-patients-with-metastatic-differentiated-thyroid-carcinoma-confined-to-the-lung
#14
Mijin Kim, Won Gu Kim, Suyeon Park, Hyemi Kwon, Min Ji Jeon, Jong Jin Lee, Jin-Sook Ryu, Tae Yong Kim, Young Kee Shong, Won Bae Kim
BACKGROUND: For patients with lung metastases of differentiated thyroid carcinoma (DTC), there is no consensus on the maximal size of metastatic lesions to use when determining the intensity of follow-up and additional therapeutic options. This study evaluated the clinical outcomes and survival of patients with metastatic DTC confined to the lung, using the maximal diameter of lung lesions in the initial computed tomography. METHODS: This retrospective cohort study included 112 DTC patients with metastases confined to the lung...
January 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27738010/comparison-of-empiric-versus-whole-body-blood-clearance-dosimetry-based-approach-to-radioactive-iodine-treatment-in-patients-with-metastases-from-differentiated-thyroid-cancer
#15
MULTICENTER STUDY
Désirée Deandreis, Carole Rubino, Hernan Tala, Sophie Leboulleux, Marie Terroir, Eric Baudin, Steve Larson, James A Fagin, Martin Schlumberger, R Michael Tuttle
The optimal management of radioactive iodine (RAI) treatment in patients with metastatic thyroid cancer (TC) is still a matter of debate. Methods: We retrospectively analyzed 352 patients with RAI-avid metastatic well-differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR, n = 231) or by personalized activity (2.7-18.6 GBq) based on whole-body/-blood clearance (WB/BC) dosimetry at Memorial Sloan Kettering Cancer Center (MSKCC, n = 121). The primary endpoint was to compare overall survival (OS) in the 2 groups of patients by log-rank test...
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27493271/tert-promoter-mutation-predicts-radioiodine-refractory-character-in-distant-metastatic-differentiated-thyroid-cancer
#16
Xue Yang, Jiao Li, Xiaoyi Li, Zhiyong Liang, Wen Gao, Jun Liang, Shujun Cheng, Yansong Lin
Telomerase reverse transcriptase (TERT) promoter mutation has been reported to be associated with aggressive characteristics in differentiated thyroid cancer (DTC). This study examined the status of TERT mutation in distant metastatic DTC and evaluated the correlation between TERT mutation and radioiodine uptake, as well as that between TERT mutation and therapy response. METHODS: TERT promoter and B-Raf proto-oncogene (BRAF) V600E mutation were retrospectively examined in primary tumors of 66 patients with distant metastatic DTC...
February 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27172937/effects-of-glycosylation-on-biodistribution-and-imaging-quality-of-necrotic-myocardium-of-iodine-131-labeled-sennidins
#17
Ling Li, Dongjian Zhang, Shengwei Yang, Shaoli Song, Jindian Li, Qin Wang, Cong Wang, Yuanbo Feng, Yicheng Ni, Jian Zhang, Wei Liu, Zhiqi Yin
PURPOSE: Sennidins are necrosis-avid agents for noninvasive assessment of myocardial viability which is important for patients with myocardial infarction (MI). However, high accumulation of radioactivity in the liver interferes with the assessment of myocardial viability. In this study, we compared sennidins with sennosides to investigate the effects of glycosylation on biodistribution and imaging quality of sennidins. PROCEDURES: Sennidin A (SA), sennidin B (SB), sennoside A (SSA), and sennoside B (SSB) were labeled with I-131...
December 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27150319/radioactive-iodine-treatment-is-associated-with-improved-survival-for-patients-with-h%C3%A3-rthle-cell-carcinoma
#18
Christa L Jillard, Linda Youngwirth, Randall P Scheri, Sanziana Roman, Julie A Sosa
BACKGROUND: Hürthle cell carcinoma (HCC) is not typically iodine avid, raising questions regarding postoperative use of radioactive iodine (RAI). The aims of this study were to describe current practice patterns regarding the use of RAI for HCC and to assess its association with survival. METHODS: The National Cancer Data Base 1998-2006 was queried for all patients with HCC who underwent total thyroidectomy. Inclusion was limited to T1 tumors with N1/M1 disease, and T2-4 tumors with any N/M disease...
July 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26872102/time-course-and-predictors-of-structural-disease-progression-in-pulmonary-metastases-arising-from-follicular-cell-derived-thyroid-cancer
#19
Mona M Sabra, Ronald Ghossein, R Michael Tuttle
BACKGROUND: With the advent of molecular targeted therapy for the management of radioactive iodine (RAI) refractory, progressive metastatic thyroid cancer, it becomes important to define the time course and risk factors for structural disease progression in follicular cell-derived thyroid cancer (FCDTC) patients. This will help in defining the optimal time to start these therapies and better define their impact on structural disease progression. OBJECTIVES: This retrospective review of 199 consecutive patients with FCDTC presenting with lung metastasis examined the progression-free survival (PFS) in thyroid cancer patients with lung metastasis treated with surgery and RAI, and who had not received molecular targeted therapy or chemotherapy...
April 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26857905/-124-i-pet-ct-in-patients-with-differentiated-thyroid-cancer-clinical-and-quantitative-image-analysis
#20
Seza A Gulec, Russ A Kuker, Mohammed Goryawala, Carlos Fernandez, Rudolfo Perez, Alina Khan-Ghany, Ana Apaza, Evis Harja, Mack Harrell
BACKGROUND: Although radioactive iodine (RAI) imaging/therapy is one of the earliest applications of theranostics, there remain a number of unresolved clinical questions as to the optimization of diagnostic techniques/protocols and improvements in patient-specific treatment planning strategies. The objectives of this study were to determine the imaging characteristics and clinical feasibility of (124)I positron emission tomography/computed tomography (PET/CT) for the determination of extent of disease and evaluation of RAI kinetics in its physiologic and neoplastic distribution in patients with differentiated thyroid cancer (DTC)...
March 2016: Thyroid: Official Journal of the American Thyroid Association
keyword
keyword
117481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"