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lymphadenopathy and BCG

Jiangan Xie, Christopher Codd, Kevin Mo, Yongqun He
M. bovis strain Bacillus Calmette-Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990. During its long time usage, different adverse events (AEs) have been reported. However, the AEs associated with the BCG preventive TB vaccine and therapeutic cancer vaccine have not been systematically compared. In this study, we systematically collected various BCG AE data mined from the US VAERS database and PubMed literature reports, identified statistically significant BCG-associated AEs, and ontologically classified and compared these AEs related to these two types of BCG vaccine...
2016: PloS One
E Bukhari, F Alaklobi, H Bakheet, A Alrabiaah, F Alotibi, F Aljobair, M Alshamrani, E Alaki, F Alnahdi, A Alodyani, F Alzamil
OBJECTIVE: The bacille Calmette Guérin (BCG) vaccine is administered worldwide to prevent tuberculosis. Although, Post BCG vaccination complications like disseminated BCG infections are rare and immunocompromised children are at high risk of developing BCG-related complications including BCG-lymphadenitis and other disseminated diseases. PATIENTS AND METHODS: This was a prospective study of children who developed disseminated BCG after vaccination who were admitted in three tertiary care hospital in Riyadh, Saudi Arabia, in the year 2015...
September 2016: European Review for Medical and Pharmacological Sciences
Ankur Kumar, Surjit Singh
No abstract text is available yet for this article.
August 2016: Arthritis & Rheumatology
Kenan Barut, Sezgin Şahin, Amra Adroviç, Özgür Kasapçopur
All inflammatory changes in the vessel wall are defined as vasculitis. Pediatric vasculitis may present with different clinical findings. Although Henoch-Schönlein purpura which is the most common pediatric vasculitis generally recovers spontaneously, it should be monitorized closely because of the risk of renal failure. Although Kawasaki disease is easy to diagnose with its classical findings, the diagnosis may be delayed in case of incomplete Kawasaki disease. Kawasaki disease should be considered especially in infants in case of prolonged fever even if the criteria are not fully met and intravenous immunoglobulin treatment should be administered without delay in order to prevent development of coronary artery aneurism...
December 2015: Türk Pediatri Arşivi
Mohammad Hasan Aelami, Abdolvahab Alborzi, Gholamreza Pouladfar, Bita Geramizadeh, Bahman Pourabbas, Jalal Mardaneh
BACKGROUND: Disseminated bacillus calmette guerin (BCG) infection is a rare but life threatening complication of BCG vaccination. It has been mainly seen in severe immune deficiency. A precise and rapid diagnosis is crucial for prompt initiation of an aggressive anti-mycobacterial treatment. Polymerase chain reaction (PCR) is directly applicable to smear-positive clinical specimens, proven to be a rapid and specific diagnostic test. OBJECTIVES: The aim of this study was to investigate disseminated BCG infection among 34 children in southern Iran, mainly confirmed by PCR...
November 2015: Jundishapur Journal of Microbiology
Ji Hae Kang, Seung Ji Hong, In Ae Seo, Min Ha Kwak, Seung Man Cho, Doo Kwon Kim, Sung Min Choi, Dong Seok Lee
BACKGROUND AND OBJECTIVES: This study aimed to investigate the clinical characteristics of infantile Kawasaki disease (KD), and to evaluate early diagnostic features of KD in febrile infants. SUBJECTS AND METHODS: We retrospectively reviewed the medical records of 64 KD patients from January 2010 to October 2014. There was an analysis of the clinical, laboratory data of the infants versus children groups. Furthermore, the clinical and laboratory data of infantile KD patients were compared with 16 infants who were admitted for other acute febrile diseases...
November 2015: Korean Circulation Journal
Ali Güneş, Ünal Uluca, Fesih Aktar, Çapan Konca, Velat Şen, Aydın Ece, Salih Hoşoğlu, Mehmet Ali Taş, Fuat Gürkan
BACKGROUND: A delay in the diagnosis and treatment of tuberculosis meningitis (TBM) may lead to increased mortality and morbidity. The aim of this study was to describe the clinical, radiological and laboratory findings of TBM on a cohort of 185 pediatric patients at a single centre over a 10 year period and to investigate relationship between the stage of the disease. METHODS: The hospital records of 185 TBM children that presented to the Pediatric Clinics of Dicle University Hospital were retrospectively evaluated...
2015: Italian Journal of Pediatrics
Shai Shrot, Galia Barkai, Aviva Ben-Shlush, Michalle Soudack
BACKGROUND: When administered to an immune-compromised patient, BCG (Bacille Calmette-Guérin) can cause disseminated and life-threatening infections. OBJECTIVE: To describe the imaging findings in children with primary immunodeficiency and BCG-related infections. MATERIALS AND METHODS: We reviewed the imaging findings of children with primary immunodeficiency treated at a children's hospital during 2012-2014 with localized or disseminated BCG infection...
February 2016: Pediatric Radiology
Megha Saroha, M M A Faridi, Prerna Batra, Iqbal Kaur, D K Dewan
Minimum gestation at which infant can be given BCG (Bacillus Calmette-Guerin) vaccine safely at birth is not clearly defined. Our objectives were the following: to compare Mantoux test after 6 months of BCG immunization in moderately preterm babies (31-33 weeks) vaccinated at birth and 34 weeks post conception age and to compare in above groups:(a) Interferon - gamma (IFN-γ) levels in BCG vaccinated infants who did not react to Mantoux test (b) Local BCG reaction at 6, 10, 14 weeks and 6 months (c) Complications of BCG vaccination...
2015: Human Vaccines & Immunotherapeutics
Güler Delibalta, Murat Seringeç, Oral Öncül
BCG (Bacillus Calmette-Guérin) vaccine is a widely used vaccine with the recommendation of World Health Organization to protect children against miliary tuberculosis (TB) and TB meningitis. Severe side effects related to this vaccine mostly manifest in the presence of underlying immunosuppressive disease. In this report, an infant case with unknown chronic granulomatous disease (CGD) who developed disseminated BCG infection after administration of BCG vaccine, was presented. High fever, left axillary lymphadenopathy and hepatosplenomegaly have developed in a 3-month 28-day female infant, without a known health problem, following BCG vaccination...
July 2015: Mikrobiyoloji Bülteni
Shima Mahmoudi, Saeid Khaheshi, Babak Pourakbari, Asghar Aghamohammadi, Sepideh Keshavarz Valian, Abbas Bahador, Farah Sabouni, Amitis Ramezani, Setareh Mamishi
PURPOSE: There are considerable variations in the number of adverse reaction reports related to vaccine from different countries. The aim of this study was to review the development of adverse reactions to bacille Calmette-Guérin (BCG) vaccination among hospitalized patients in an Iranian referral hospital. MATERIALS AND METHODS: We identified hospitalized patients with BCG complications in Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran during January 2007-April 2009...
July 2015: Clinical and Experimental Vaccine Research
Edgar Borges de Oliveira-Junior, Nuria Bengala Zurro, Carolina Prando, Otavio Cabral-Marques, Paulo Vitor Soeiro Pereira, Lena-Friederick Schimke, Stefanie Klaver, Marcia Buzolin, Lizbeth Blancas-Galicia, Leopoldo Santos-Argumedo, Dino Roberto Pietropaolo-Cienfuegos, Francisco Espinosa-Rosales, Alejandra King, Ricardo Sorensen, Oscar Porras, Persio Roxo-Junior, Wilma Carvalho Neves Forte, Julio Cesar Orellana, Alejandro Lozano, Miguel Galicchio, Lorena Regairaz, Anete Sevciovic Grumach, Beatriz Tavares Costa-Carvalho, Jacinta Bustamante, Liliana Bezrodnik, Matias Oleastro, Silvia Danielian, Antonio Condino-Neto
AIM: We analyzed data from 71 patients with chronic granulomatous disease (CGD) with a confirmed genetic diagnosis, registered in the online Latin American Society of Primary Immunodeficiencies (LASID) database. RESULTS: Latin American CGD patients presented with recurrent and severe infections caused by several organisms. The mean age at disease onset was 23.9 months, and the mean age at CGD diagnosis was 52.7 months. Recurrent pneumonia was the most frequent clinical condition (76...
December 2015: Pediatric Blood & Cancer
Cengiz Çavuşoğlu, Neslihan Edeer Karaca, Elif Azarsız, Ezgi Ulusoy, Necil Kütükçüler
It is well known that disseminated Mycobacterium bovis BCG infection is developed after BCG vaccination in infants with congenital cellular immune deficiencies such as mutations in genes along the interleukin (IL)-12/interferon (IFN)-γ pathway and mutations in nuclear factor-kB essential modulator (NEMO). In this report, a rifampicin-resistant M.bovis BCG strain isolated from an infant with NEMO defect was presented. An 8-month-old male infant with NEMO defect admitted to the pediatric outpatient clinic of our hospital with fever, generalized lymphadenopathy and hepatosplenomegaly...
April 2015: Mikrobiyoloji Bülteni
Subrata Pal, Srabani Chakarabarti, Jyoti Prakash Phukan, Sudhanya Biswas, Anuradha Sinha, Rajani Sinha
CONTEXT: Regional lymphadenitis is the most common complication of bacille Calmette-Guerin (BCG) vaccination. Most of the BCG lymphadenitis cases are nonsuppurative, but some suppurate and follow abscess formation, rupture, ulceration and cicatrization. Needle aspiration is the rapid, safe and cost-effective method for diagnosis as well as management of suppurative BCG adenitis. AIMS: The aims of the present study were to assess the clinical and cytological spectrum of BCG lymphadenitis and to evaluate the role of needle aspiration in the management of suppurative BCG lymphadenitis...
January 2015: Journal of Laboratory Physicians
Hazel J Clothier, Laine Hosking, Nigel W Crawford, Melissa Russell, Mee Lee Easton, Julie-Ann Quinn, Jim P Buttery
BACKGROUND: Bacillus Calmette-Guérin (BCG) vaccine is used worldwide, with high efficacy against childhood Mycobacterium tuberculosis (TB) meningitis and miliary TB. BCG vaccine is considered safe, with serious systematic adverse events following immunization (AEFI) of immunocompetent recipients being rare, although adverse event rates vary between differing BCG strains. In Victoria, Australia, AEFI are reported to SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community), an enhanced passive surveillance system operational since 2007...
January 2015: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Mohammad Sadegh Rezai, Soheila Shahmohammadi
INTRODUCTION: Kawasaki disease is an acute, self-limiting childhood systemic vasculitis with unknown etiology. Because there is no diagnostic test for Kawasaki disease, the diagnosis is based on clinical criteria. An important clinical sign that is not included in the classical clinical criteria for Kawasaki disease is a reaction at the Bacille Calmette-Guérin inoculation site that are present in about 30-50% of Kawasaki disease patients. THE AIM: of this review was to highlight the usefulness of the inflammation at the Bacille Calmette-Guérin inoculation site for early diagnosis of Kawasaki disease, we conducted a literature review on Medline in PubMed area, Google scholar, Magiran and Scientific Information Database using the search terms "Kawasaki disease, Erythema, BCG, inoculation site, children, cardiac complications, coronary artery lesion, aneurysm, incomplete Kawasaki in 2013...
August 2014: Materia Socio-medica
Robert Trimble, Jane Atkins, Troy C Quigg, Cara C Burns, Gregory S Wallace, Mary Thomas, Anil T Mangla, Anthony J Infante
Poliovirus transmission has been eliminated in most of the world through the use of inactivated poliovirus vaccine (IPV) and live, attenuated oral poliovirus vaccine (OPV). In the United States, use of OPV was discontinued by the year 2000 because of the potential for vaccine-associated paralytic polio (VAPP); an average of eight cases were reported each year in the United States during 1980-2000. Polio eradication efforts in other parts of the world continue to rely on OPV to take advantage of transmission of poliovirus vaccine strains to unvaccinated persons in the population, lower cost, and ease of administration...
August 22, 2014: MMWR. Morbidity and Mortality Weekly Report
Manouri P Senanayake, D S Kumararatne, Rainer Doffinger, Gabriela Barcenas-Morales
Although neonatal vaccination with bacille Calmette-Guérin (BCG) is considered to be safe, complications with disseminated disease are associated with underlying immuno-deficiency disorders. A BCG-vaccinated 4-month-old girl of Sri Lankan parentage developed progressive left axillary lymphadenopathy and severe bronchopneumonia. Lymph node biopsy demonstrated epithelioid granulomata and acid-fast bacilli. An older sibling had had a similar clinical presentation and the outcome had been fatal. Investigation for immuno-deficiency detected complete IL12RB1 deficiency...
February 2015: Paediatrics and International Child Health
K Sharma, N Gupta, A Sharma, G Singh, P K Gupta, A Rajwanshi, S C Varma, M Sharma
PURPOSE: Tubercular lymphadenitis (TBLA) is a common manifestations of extrapulmonary tuberculosis (EPTB) accounting for 30-40% of cases. Prompt diagnosis and timely initiation of anti-tubercular therapy (ATT) is the key for successful clinical outcome. This study was carried out to evaluate multiplex polymerase chain reaction (MPCR) using MPB64 and IS6110, and compare with the conventional methods for rapid diagnosis of TBLA. MATERIALS AND METHODS: In our study, lymph node fine-needle aspirates of patients were evaluated for TBLA...
January 2013: Indian Journal of Medical Microbiology
Edwin Miranda-Choque, Jorge Candela-Herrera, Eddy R Segura, Sonia Farfán-Ramos, Aldo Barriga
The objective of this study is to describe the clinical profile of the immune reconstitution syndrome due to Mycobacterium bovis Bacillus Calmette-Guérin (IRS-BCG) in children with HIV infection who receive highly active antiretroviral treatment (HAART) at Instituto Nacional de Salud del Niño de Lima (National Children's Health Institute of Lima), Peru. A case study was conducted, including 8 children with IRS-BCG, defined as the presence of regional lymphadenopathy or inflammation on the BCG vaccination site with at least one less logarithm in the viral load or immune improvement...
October 2012: Revista Peruana de Medicina Experimental y Salud Pública
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