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BCG-osis in childrens

R C de Souza Campos Fernandes, E Medina-Acosta
Although vaccination with Bacille Calmette-Guérin (BCG) is considered safe, adverse regional (BCG-itis) and disseminated (BCG-osis) diseases preferentially occur in the immunocompromised host. The infection with human immunodeficiency virus (HIV) by mother-to-child transmission leads to impaired cellular immune responses, a situation that poses a great challenge regarding the universal use of BCG vaccine. World Health Organization recommends that children who are known to be HIV-infected, even if asymptomatic, should no longer be immunized with BCG...
September 2010: International Journal of STD & AIDS
Djordje Jevtović, Dubravka Salemović, Jovan Ranin, Branko Brmbolić, Olgica Djurković-Djaković
To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72...
May 2009: Current HIV Research
Mahnaz Sadeghi-Shabestari, Nima Rezaei
BACKGROUND: The bacille Calmette-Guérin (BCG) vaccine is a widely practiced vaccine, which is useful for prophylaxis against tuberculosis. Disseminated BCG infection (BCG-osis) is one of the most important complications of this vaccine and can be seen in patients with an underlying immunodeficiency. This study was performed to determine the underlying defects in patients with BCG-osis. METHODS: Immunological evaluation was performed in all children who developed BCG-osis after vaccination in Tabriz, Iran...
November 2009: International Journal of Infectious Diseases: IJID
Jacinta Bustamante, Guzide Aksu, Guillaume Vogt, Ludovic de Beaucoudrey, Ferah Genel, Ariane Chapgier, Orchidée Filipe-Santos, Jacqueline Feinberg, Jean-François Emile, Necil Kutukculer, Jean-Laurent Casanova
A few known primary immunodeficiencies confer predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG vaccines (regional disease, known as BCG-itis, or disseminated disease, known as BCG-osis), or more virulent mycobacteria, such as Mycobacterium tuberculosis (pulmonary and disseminated tuberculosis). We investigated the clinical and genetic features of a 12-year-old boy with both recurrent BCG-osis and disseminated tuberculosis. The patient's phagocytic cells produced no O(2)(-)...
July 2007: Journal of Allergy and Clinical Immunology
Jalel Chemli, Mohamed-Ridha Barbouche, Najet Missaoui, Youssef Lakhoua, Koussey Dellagi, Ahmed-Sahloul Essoussi, Abdelaziz Harbi
UNLABELLED: In order to analyze the current epidemiological pattern of mycobacterial infection in children in Central Tunisia, we studied retrospectively the clinical feature of 31 children with mycobacterial infection enrolled in the pediatrics department of Sousse during eight years period (1994-2001). Twenty three boys and eight girls aged two months to 13 years (mean age: 4 years and 8 months) were investigated. Among them, 24 patients suffered of tuberculosis (TBC) and 7 of disseminated BCG-osis...
December 2006: La Tunisie Médicale
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