keyword
MENU ▼
Read by QxMD icon Read
search

Extended spectrum beta-lactamases

keyword
https://www.readbyqxmd.com/read/28425271/molecular-characteristics-and-antibiotic-resistance-of-acinetobacter-baumanniibeta-lactamase-producing-isolates-a-predominance-of-intrinsic-blaoxa-51-and-detection-of-tem-and-ctx-m-genes
#1
Amir Ibrahimagić, Farah Kamberović, Selma Uzunović, Branka Bedenić, Emina Idrizović
BACKGROUND/AIM: The aim of this study was to determine the molecular characteristics and antibiotic resistance of 13 (10 inpatient and three outpatient) Acinetobacter baumannii beta-lactamase-producing isolates collected in Bosnia and Herzegovina between December 2009 and May 2010. MATERIALS AND METHODS: Susceptibility testing was performed by disk diffusion and broth microdilution methods. The modified Hodge and combined disk test with EDTA/phenylboronic acid was used to screen for carbapenemase production...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28420677/tcup-typing-and-characterization-of-bacteria-using-bottom-up-tandem-mass-spectrometry-proteomics
#2
Fredrik Boulund, Roger Karlsson, Lucia Gonzales-Siles, Anna Johnning, Nahid Karami, Omar Al-Bayati, Christina Ahren, Edward R B Moore, Erik Kristiansson
Methods for rapid and reliable microbial identification are essential in modern healthcare. The ability to detect and correctly identify pathogenic species and their resistance phenotype is necessary for accurate diagnosis and efficient treatment of infectious diseases. Bottom-up tandem mass spectrometry (MS) proteomics enables rapid characterization of large parts of the expressed genes of microorganisms. However, the generated data is highly fragmented, making down-stream analyses complex. Here we present TCUP, a new computational method for typing and characterizing bacteria using proteomics data from bottom-up tandem MS...
April 18, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28415986/detection-of-ctx-m-15-beta-lactamases-in-enterobacteriaceae-causing-hospital-and-community-acquired-urinary-tract-infections-as-early-as-2004-in-dar-es-salaam-tanzania
#3
Joel Manyahi, Sabrina J Moyo, Marit Gjerde Tellevik, Faustine Ndugulile, Willy Urassa, Bjørn Blomberg, Nina Langeland
BACKGROUND: The spread of Extended Spectrum β-lactamases (ESBLs) among Enterobacteriaceae and other Gram-Negative pathogens in the community and hospitals represents a major challenge to combat infections. We conducted a study to assess the prevalence and genetic makeup of ESBL-type resistance in bacterial isolates causing community- and hospital-acquired urinary tract infections. METHODS: A total of 172 isolates of Enterobacteriaceae were collected in Dar es Salaam, Tanzania, from patients who met criteria of community and hospital-acquired urinary tract infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28408938/bacteraemia-in-intensive-care-unit-clinical-bacteriological-and-prognostic-prospective-study
#4
Zineb Lachhab, Mohammed Frikh, Adil Maleb, Jalal Kasouati, Nouafal Doghmi, Yassine Ben Lahlou, Bouchra Belefquih, Abdelhay Lemnouer, Mostafa Elouennass
Objectives. We conducted a one-year observational study from December 2012 to November 2013 to describe the epidemiology of bacteraemia in intensive care units (ICU) of Mohammed V Military Teaching Hospital of Rabat (Morocco). Methods. The study consisted of monitoring all blood cultures coming from intensive care units and studying the bacteriological profile of positive blood cultures as well as their clinical significance. Results. During this period, a total of 46 episodes of bacteraemia occurred, which corresponds to a rate of 15,4/1000 patients...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28397262/extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-and-klebsiella-pneumoniae-critical-tools-for-antibiotic-resistance-pattern
#5
REVIEW
Nagarajan Padmini, Antony Alex Kennedy Ajilda, Natesan Sivakumar, Gopal Selvakumar
Drug resistance is a phenomenon where by an organism becomes fully or partially resistant to drugs or antibiotics being used against it. Antibiotic resistance poses an exacting intimidation for people with underlying medical immune conditions or weakened immune systems. Infections caused by the enzyme extended spectrum β-lactamase (ESBL) producing multi drug resistance (MDR) Enterobacteriaceae especially Escherichia coli and Klebsiella pneumoniae are resistant to a broad range of beta lactams, including third generation cephalosporins...
April 11, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28397101/direct-detection-of-extended-spectrum-beta-lactamases-ctx-m-from-blood-cultures-by-lc-ms-ms-bottom-up-proteomics
#6
F Fleurbaaij, W Goessens, H C van Leeuwen, M E M Kraakman, S T Bernards, P J Hensbergen, E J Kuijper
Rapid bacterial species identification and antibiotic susceptibility testing in positive blood cultures have an important impact on the antibiotic treatment for patients. To identify extended-spectrum beta-lactamases (ESBL) directly in positive blood culture bottles, we developed a workflow of saponin extraction followed by a bottom-up proteomics approach using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The workflow was applied to positive blood cultures with Escherichia coli and Klebsiella pneumoniae collected prospectively in two academic hospitals over a 4-month period...
April 10, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28396549/in-vivo-pharmacokinetics-and-pharmacodynamics-of-zti-01-fosfomycin-for-injection-in-the-neutropenic-murine-thigh-infection-model-against-e-coli-k-pneumoniae-and-p-aeruginosa
#7
Alexander J Lepak, Miao Zhao, Brian VanScoy, Daniel S Taylor, Evelyn Ellis-Grosse, Paul G Ambrose, David R Andes
Fosfomycin is a broad-spectrum agent with activity against gram-positive and gram-negative bacteria, including drug-resistant strains, such as extended spectrum beta-lactamase (ESBL)-producing and carbapenem-resistant (CR) gram-negative rods. In the present study, the pharmacokinetic/pharmacodynamic (PK/PD) activity of ZTI-01 (fosfomycin for injection) was evaluated in the neutropenic murine thigh infection model against 5 E. coli (EC), 3 K. pneumoniae (KPN), and 2 P. aeruginosa (PSA) strains, including a subset with ESBL and CR phenotype...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28390979/urinary-tract-infections-among-kidney-transplant-patients-due-to-extended-spectrum-beta-lactamase-producing-bacteria
#8
Masoomeh Kashef Nejad, Nima Hosseini Jazani, Yaeghob Sharifi
No abstract text is available yet for this article.
April 5, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28390886/epidemiology-and-antibiotic-resistance-of-late-prosthetic-knee-and-hip-infections
#9
Lorenzo Drago, Elena De Vecchi, Monica Bortolin, Luigi Zagra, Carlo L Romanò, Laura Cappelletti
BACKGROUND: Prosthetic joint infections (PJI) are still a major complication of hip and knee arthroplasties. Identification of the causative pathogens and knowledge of their antibiotic susceptibilities are essential for the management of these infections. The main purpose of the study was to identify and compare the causative bacteria of prosthetic knee and hip joint infections in a reference Italian orthopedic center and to characterize antibiotic resistance profiles of bacteria involved...
March 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28383517/antibiotic-resistance-in-an-indian-rural-community-a-one-health-observational-study-on-commensal-coliform-from-humans-animals-and-water
#10
Manju Raj Purohit, Salesh Chandran, Harshada Shah, Vishal Diwan, Ashok J Tamhankar, Cecilia Stålsby Lundborg
Antibiotic-resistant bacteria are an escalating grim menace to global public health. Our aim is to phenotype and genotype antibiotic-resistant commensal Escherichia coli (E. coli) from humans, animals, and water from the same community with a 'one-health' approach. The samples were collected from a village belonging to demographic surveillance site of Ruxmaniben Deepchand (R.D.) Gardi Medical College Ujjain, Central India. Commensal coliforms from stool samples from children aged 1-3 years and their environment (animals, drinking water from children's households, common source- and waste-water) were studied for antibiotic susceptibility and plasmid-encoded resistance genes...
April 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28379311/contact-precautions-for-preventing-nosocomial-transmission-of-esbl-producing-escherichia-coli-a-point-counterpoint-review
#11
Sarah Tschudin-Sutter, Jean-Christophe Lucet, Nico T Mutters, Evelina Tacconelli, Jean Ralph Zahar, Stephan Harbarth
Contact precautions have been recommended for hospitalized patients colonized or infected with extendend-spectrum beta-lactamase (ESBL)-producing Escherichia coli. Despite such recommendations, a steady, worldwide increase of ESBL-E. coli has been reported. We discuss arguments in favor and against contact precautions for ESBL- E.coli-carriers.Healthcare settings with high ESBL-E.coli colonization pressure, extended hospital stay and close contact between vulnerable patients may serve as amplification platform further accelerating transmission...
April 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28378973/tawny-owl-strix-aluco-as-a-potential-transmitter-of-enterobacteriaceae-epidemiologically-relevant-for-forest-service-workers-nature-protection-service-and-ornithologists
#12
Grzegorz Grzywaczewski, Danuta Kowalczyk-Pecka, Szymon Cios, Wiktor Bojar, Andrzej Jankuszew, Hubert Bojar, Marcin Kolejko
Established taxa within the Enterobacteriaceae wereisolated from cloacal swabs of Strix aluco chicks in nest boxes located at five research sites. ChromID ESBL medium (bioMerieux) was used to select a pool of Enterobacteriaceae strains producing extended-spectrum beta-lactamases. Drug sensitivity of the chosen strains was determined from the full pool of Enterobacteriaceae to 6 chemotherapeutics of different mechanisms of action. The study evaluated the sensitivity of ESBL-synthesizing isolates to substances belonging to penicillins, cephalosporins, cephamycins, clavams, carbapenems and monobactams...
March 31, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28377310/risk-factors-for-extended-spectrum-beta-lactamase-producing-escherichia-coli-urinary-tract-infection-in-the-community-in-denmark-a-case-control-study
#13
Mette Søgaard, Uffe Heide-Jørgensen, Jan P Vandenbroucke, Henrik C Schønheyder, Christina Mje Vandenbroucke-Grauls
OBJECTIVE: To verify the role of proton pump inhibitors (PPI) and nitrofurantoin, which have appeared as novel risk factors for carriage of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, as risk factors for ESBL E.coli urinary tract infection (UTI). We included known risk factors to ascertain whether our findings are comparable with previous studies. METHODS: Population-based case-control study including 339 cases with community-onset ESBL E...
April 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28373776/severe-infection-with-multidrug-resistant-salmonella-choleraesuis-in-a-young-patient-with-primary-sclerosing-cholangitis
#14
Philip G Ferstl, Claudia Reinheimer, Katalin Jozsa, Stefan Zeuzem, Volkhard Aj Kempf, Oliver Waidmann, Georgios Grammatikos
Massive global spread of multidrug-resistant (MDR) Salmonella spp. expressing extended-spectrum beta-lactamase (ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28368864/characterization-of-esbl-producing-escherichia-coli-recovered-from-companion-dogs-in-tai-an-china
#15
Song Li, Junhe Liu, Yufa Zhou, Zengmin Miao
INTRODUCTION: Animals are considered to be reservoirs of extended-spectrum beta-lactamase (ESBL)-producing bacteria, but few epidemiological data on ESBL-producing Escherichia coli urinary tract isolates in pet dogs are available in China. METHODOLOGY: This study was conducted to describe the prevalence and characterization of ESBL producers among E. coli urinary tract isolates from pet dogs in Tai'an, China. RESULTS: A total of 118 E. coli were obtained from urinary samples of 80 companion dogs suffering from acute or chronic cystitis, of which three isolates from different dogs were ESBL producers...
March 31, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28367879/phenotypic-and-molecular-characterization-of-enteroaggregative-escherichia-coli-isolated-in-kawasaki-japan
#16
Akiko Kubomura, Takako Misaki, Sachiko Homma, Chiaki Matsuo, Nobuhiko Okabe
Enteroaggregative Escherichia coli (EAEC), an enteric pathogen, causes persistent diarrhea in children, HIV-infected individuals, and travelers in economically developing countries. However, the pathogenesis of EAEC infection is not well understood. The aim of this study is to characterize EAEC in Japan. During 2012-2014, we identified 40 EAEC strains carrying the aggR gene at the Kawasaki City Institute for Public Health, Japan. We characterized these strains using O:H-antigen typing, polymerase chain reaction (for pCVD432, astA, extended-spectrum beta-lactamase, and four aggregative adherence fimbriae genes), HEp-2 cell adherence, clump formation, and antimicrobial susceptibility testing...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28367020/comparison-of-four-phenotypic-methods-for-detection-of-metallo-%C3%AE-lactamase-producing-gram-negative-bacteria-in-rural-teaching-hospital
#17
Chinjal A Panchal, Sweta Sunil Oza, Sanjay J Mehta
CONTEXT: Metallo-β-lactamase (MBL)-producing bacteria lead to resistance to carbapenem an antibiotic that used as the last resort for treatment of multidrug-resistant bacteria, extended spectrum beta-lactamases, and AmpC β-lactamase-producing Gram-negative bacteria (GNB). The emergence of MBL-producing GNB is challenge to microbiology laboratories because there are no standardized guidelines available to detect them. The aim of this study was to compare four phenotypic methods to detect MBL production in GNB and to determine antibiotic sensitivity of MBL-producing isolates...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28364731/clonal-diversity-of-extended-spectrum-beta-lactamase-producing-escherichia-coli-isolates-in-fecal-samples-of-wild-animals
#18
Filipe Cristóvão, Carla Andrea Alonso, Gilberto Igrejas, Margarida Sousa, Vanessa Silva, José Eduardo Pereira, Carmen Lozano, Gerardo Cortés-Cortés, Carmen Torres, Patrícia Poeta
The clonal diversity of extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli isolates from nine different species of wild animals from distinct regions of Portugal and Spain and their content in replicon plasmids were analyzed. Among the initial 53 ESBL-producing E. coli isolates that were studied (from previous studies), 28 were selected, corresponding to different animal origins with distinct ESBL types and pulsed-field gel electrophoresis (PFGE) patterns. These 28 isolates produced different ESBLs ascribed to the following families: CTX-M, SHV and TEM...
March 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28359312/extended-spectrum-beta-lactamase-producing-pseudomonas-aeruginosa-in-camel-in-egypt-potential-human-hazard
#19
Mahmoud Elhariri, Dalia Hamza, Rehab Elhelw, Sohad M Dorgham
BACKGROUND: The rapid increase of extended-spectrum beta-lactamase (ESBL) producing bacteria are a potential health hazard. Development of antimicrobial resistance in animal pathogens has serious implications for human health, especially when such strains could be transmitted to human. In this study, the antimicrobial resistance due to ESBL producing Pseudomonas aeruginosa in the camel meat was investigated. METHODS: In this study meat samples from 200 healthy camels at two major abattoirs in Egypt (Cairo and Giza) were collected...
March 31, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28355599/urinary-infections-in-patients-with-catheters-in-the-upper-urinary-tract-microbiological-study
#20
Alba Lara-Isla, José Medina-Polo, Manuel Alonso-Isa, Raúl Benítez-Sala, Raquel Sopeña-Sutil, Juan Justo-Quintas, Javier Gil-Moradillo, Daniel A González-Padilla, Esther García-Rojo, Juan Bautista Passas-Martínez, Ángel Tejido-Sánchez
BACKGROUND: Infections related to catheters in the upper urinary tract (CUUT) are associated with specific characteristics. METHODS: A prospective observational study was carried out from 2012 to 2015 to evaluate infections in patients with CUUT. RESULTS: A total of 209 infections were included (99 with double-J, 81 with nephrostomy, and 29 with internal/external nephroureteral stents). Among nephrostomy tube carriers, the most frequently isolated microorganisms were Pseudomonas and Enterococcus...
March 30, 2017: Urologia Internationalis
keyword
keyword
117472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"