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https://www.readbyqxmd.com/read/28717298/ameloblastic-carcinoma-a-rare-malignant-tumour-in-maxillofacial-region
#1
Pushkar Devidas Gawande, Kiran Khande, Gaurav Agrawal, Amita Aditya
Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with poor prognosis. It has an aggressive clinical course with extensive local destruction. It occurs primarily in the mandible. It may clinically present as a cystic lesion with benign clinical feature or as a large mass with ulceration, significant bone resorption and mobility of teeth in the affected region. Reliable evidence of it's biological activity along with extensive local destruction, direct extension of tumor, lymph node involvement and metastasis to various sites (frequently lung) have been reported...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28715875/acute-orexigenic-effect-of-agmatine-involves-interaction-between-central-%C3%AE-2-adrenergic-and-gabaergic-receptors
#2
Brijesh Gulabrao Taksande, Omi Sharma, Manish Manohar Aglawe, Mayur Bhimrao Kale, Dinesh Yugraj Gawande, Milind Janraoji Umekar, Nandkishor Ramdas Kotagale
Agmatine and GABA have been abundantly expressed in brain nuclei involved in regulation of energy homeostasis and promoting stimulation of food intake in rodents. However, their mutual interaction, if any, in the elicitation of feeding behavior is largely remains unclear. The current study provides experimental evidence for the possible interaction of agmatine, adrenergic and GABAergic systems in stimulation of feeding in satiated rats. Satiated rats fitted with intracerebroventricular (i.c.v.) cannulae and were administered agmatine, alone or jointly with (a) GABAA receptor agonist, muscimol, diazepam or antagonist bicuculline and flumazenil, GABAA positive modulator, allopregnanolone or negative modulator of GABAA receptor, dehydroepiandrosterone (b) In view of the high affinity of agmatine for α2-adrenoceptors and the close association between α2-adrenoceptors and GABAergic system, the effect of their modulators on feeding elicited by agmatine/GABAergic agonists were also examined...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28697107/relationship-between-labor-and-delivery-unit-management-practices-and-maternal-outcomes
#3
Avery C Plough, Grace Galvin, Zhonghe Li, Stuart R Lipsitz, Shehnaz Alidina, Natalie J Henrich, Lisa R Hirschhorn, William R Berry, Atul A Gawande, Doris Peter, Rory McDonald, Donna L Caldwell, Janet H Muri, Debra Bingham, Aaron B Caughey, Eugene R Declercq, Neel T Shah
OBJECTIVE: To define, measure, and characterize key competencies of managing labor and delivery units in the United States and assess the associations between unit management and maternal outcomes. METHODS: We developed and administered a management measurement instrument using structured telephone interviews with both the primary nurse and physician managers at 53 diverse hospitals across the United States. A trained interviewer scored the managers' interview responses based on management practices that ranged from most reactive (lowest scores) to most proactive (highest scores)...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28684037/neglected-bilateral-radial-head-fracture-with-a-rare-presentation-a-case-report
#4
Jeetesh Gawande, Siddharth Jain, John A Santoshi
Isolated radial head fractures are rare and comprise about 2% of all fractures around the elbow. Bilateral radial head fractures are even rarer and few cases have been reported. We present a case of bilateral elbow effusion in a 28-year-old male patient. An initial diagnosis of inflammatory arthritis was made but on investigation it turned out to be a case of bilateral radial head fracture. The patient was managed conservatively with 10 days of immobilisation in above elbow slab followed by active elbow range of movement exercises...
May 29, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28679813/a-systematic-intervention-to-improve-serious-illness-communication-in-primary-care
#5
Joshua R Lakin, Luca A Koritsanszky, Rebecca Cunningham, Francine L Maloney, Brandon J Neal, Joanna Paladino, Marissa C Palmor, Christine Vogeli, Timothy G Ferris, Susan D Block, Atul A Gawande, Rachelle E Bernacki
Improving communication about goals and values for patients with advancing serious illness nearing the end of life is a key opportunity to improve the value of care. The Serious Illness Care Program, implemented at primary care clinics affiliated with Brigham and Women's Hospital in Boston, Massachusetts, is a multicomponent intervention designed to support best practices in communication by clinicians to increase conversations with patients with serious illness about their goals and values. We conducted a study of the program in fourteen primary care clinics participating in a high-risk care management program based in an accountable care organization...
July 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28672080/ki67-cd105-and-%C3%AE-sma-expression-better-relates-the-binary-oral-epithelial-dysplasia-grading-system-of-world-health-organization
#6
Amol Ramchandra Gadbail, Minal S Chaudhary, Sachin C Sarode, Madhuri Gawande, Sheetal Korde, Satyajit Ashok Tekade, Shailesh Gondivkar, Alka Hande, Rupesh Maladhari
BACKGROUND: The binary system of oral epithelial dysplasia (OED) has never been investigated with reference to the carcinogenesis related biomarkers. Hence, Ki67, CD105, and α-SMA immune-expression were studied in oral potentially malignant disorders (OPMDs) to assess their relationship with the binary OED grading system of World Health Organization. METHODS: The study was carried out on paraffin-embedded tissues of 30 normal oral mucosa (NOM) and 140 OPMD cases...
July 3, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28658917/early-stage-oral-submucous-fibrosis-is-characterized-by-increased-vascularity-as-opposed-to-advanced-stages
#7
Satyajit Ashok Tekade, Minal S Chaudhary, Suruchi Satyajit Tekade, Sachin C Sarode, Sangeeta Panjab Wanjari, Amol Ramchandra Gadbail, Panjab V Wanjari, Madhuri Nitin Gawande, Sheetal Korde-Choudhari, Prajakta Zade
INTRODUCTION: The degree of vascularity of the diseased mucosa in Oral Submucous Fibrosis (OSMF) has always been a matter of debate with conflicting results. Knowledge of this aspect is important to understand pathogenesis of OSMF, which in future could be translated into therapeutic strategies. AIM: In the present study, attempt has been made to investigate parameters like Mean Vascular Density (MVD), Total Vascular Area (TVA) and Mean Vascular Area (MVA) using CD34 antibody...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28657942/perception-of-safety-of-surgical-practice-among-operating-room-personnel-from-survey-data-is-associated-with-all-cause-30-day-postoperative-death-rate-in-south-carolina
#8
George Molina, William R Berry, Stuart R Lipsitz, Lizabeth Edmondson, Zhonghe Li, Bridget A Neville, Aunyika T Moonan, Lorri R Gibbons, Atul A Gawande, Sara J Singer, Alex B Haynes
OBJECTIVE: To evaluate whether the perception of safety of surgical practice among operating room (OR) personnel is associated with hospital-level 30-day postoperative death. BACKGROUND: The relationship between improvements in the safety of surgical practice and benefits to postoperative outcomes has not been demonstrated empirically. METHODS: As part of the Safe Surgery 2015: South Carolina initiative, a baseline survey measuring the perception of safety of surgical practice among OR personnel was completed...
June 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28655801/the-betterbirth-program-pursuing-effective-adoption-and-sustained-use-of-the-who-safe-childbirth-checklist-through-coaching-based-implementation-in-uttar-pradesh-india
#9
Nabihah Kara, Rebecca Firestone, Tapan Kalita, Atul A Gawande, Vishwajeet Kumar, Bhala Kodkany, Rajiv Saurastri, Vinay Pratap Singh, Pinki Maji, Ami Karlage, Lisa R Hirschhorn, Katherine Ea Semrau
Shifting childbirth into facilities has not improved health outcomes for mothers and newborns as significantly as hoped. Improving the quality and safety of care provided during facility-based childbirth requires helping providers to adhere to essential birth practices-evidence-based behaviors that reduce harm to and save lives of mothers and newborns. To achieve this goal, we developed the BetterBirth Program, which we tested in a matched-pair, cluster-randomized controlled trial in Uttar Pradesh, India. The goal of this intervention was to improve adoption and sustained use of the World Health Organization Safe Childbirth Checklist (SCC), an organized collection of 28 essential birth practices that are known to improve the quality of facility-based childbirth care...
June 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28655800/improving-adherence-to-essential-birth-practices-using-the-who-safe-childbirth-checklist-with-peer-coaching-experience-from-60-public-health-facilities-in-uttar-pradesh-india
#10
Megan Marx Delaney, Pinki Maji, Tapan Kalita, Nabihah Kara, Darpan Rana, Krishan Kumar, Jenny Masoinneuve, Simon Cousens, Atul A Gawande, Vishwajeet Kumar, Bhala Kodkany, Narender Sharma, Rajiv Saurastri, Vinay Pratap Singh, Lisa R Hirschhorn, Katherine Ea Semrau, Rebecca Firestone
BACKGROUND: Adherence to evidence-based essential birth practices is critical for improving health outcomes for mothers and newborns. The WHO Safe Childbirth Checklist (SCC) incorporates these practices, which occur during 4 critical pause points: on admission, before pushing (or cesarean delivery), soon after birth, and before discharge. A peer-coaching strategy to support consistent use of the SCC may be an effective approach to increase birth attendants' adherence to these practices...
June 27, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28636831/health-insurance-coverage-and-health-what-the-recent-evidence-tells-us
#11
Benjamin D Sommers, Atul A Gawande, Katherine Baicker
The national debate over the Affordable Care Act (ACA) has involved substantial discussion about what effects — if any — insurance coverage has on health and mortality. The prospect that the law’s replacement might lead to millions of Americans losing coverage has brought this empirical question..
June 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28586743/agmatine-for-combined-treatment-of-epilepsy-depression-and-cognitive-impairment-in-chronic-epileptic-animals
#12
Tanveer Singh, Neetu Bagga, Anureet Kaur, Navjot Kaur, Dinesh Yugraj Gawande, Rajesh Kumar Goel
Epilepsy is fourth most common neurological disorders associated with depression and cognitive deficits. As per present scenario, none of the antiseizure drugs have been reported successful to have ameliorative effect on epilepsy associated depression and cognitive deficits. Thus, the study was envisioned to assess an ameliorative potential of agmatine on epilepsy and its efficacy and safety for management of associated depression and cognitive deficits. The animals were made epileptic employing pentylenetetrazole (35mg/kg i...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28584534/impact-of-virtual-microscopy-with-conventional-microscopy-on-student-learning-in-dental-histology
#13
Alka Harish Hande, Vidya K Lohe, Minal S Chaudhary, Madhuri N Gawande, Swati K Patil, Prajakta R Zade
BACKGROUND: In dental histology, the assimilation of histological features of different dental hard and soft tissues is done by conventional microscopy. This traditional method of learning prevents the students from screening the entire slide and change of magnification. To address these drawbacks, modification in conventional microscopy has evolved and become motivation for changing the learning tool. Virtual microscopy is the technique in which there is complete digitization of the microscopic glass slide, which can be analyzed on a computer...
March 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28561577/developments-in-the-reactivity-of-2-methylimidazolium-salts
#14
Daniela Peixoto, Margarida Figueiredo, Manoj B Gawande, Marta C Corvo, Gerd Vanhoenacker, Carlos A M Afonso, Luisa M Ferreira, Paula S Branco
Unexpected and unusual reactivity of 2-methylimidazolium salts toward aryl-N-sulfonylimines and aryl aldehydes is here reported. Upon reaction with aryl-N-sulfonylimines, the addition product, arylethyl-2-imidazolium-1-tosylamide (3), is formed with moderate to good yields, while upon reaction with aldehydes, the initial addition product (6) observed in NMR and HPLC-MS experimental analysis is postulated by us as an intermediate to the final conversion to carboxylic acids. Studies in the presence and absence of molecular oxygen allow us to conclude that the imidazolium salts is crucial for the oxidation...
June 8, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28553908/from-silence-into-language-questioning-the-power-of-physician-illness-narratives
#15
Amy E Caruso Brown, Rebecca Garden
Physicians' narratives of their own experiences of illness can be a kind of empathic bridge across the divide between a professional healer and a sick patient. This essay considers ways in which physicians' narratives of their own and family members' experiences of cancer shape encounters with patients and patients' experiences of illness. It analyzes ethical dimensions of physicians' narratives (such as those by Atul Gawande, Siddhartha Mukherjee, and Paul Kalanithi) and of reflective writing in medical education...
May 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28492996/patient-perspectives-on-barriers-to-surgical-care-and-the-impact-of-mobile-surgery-in-ecuador
#16
Matthew D Price, Haadi T Shalabi, Blasco Guzhñay, Saggah T Shalabi, Raymond R Price, Edgar B Rodas
BACKGROUND: An estimated 5 billion people worldwide lack access to timely safe surgical care (Gawande in Lancet 386(9993):523-525, 2015). A mere 6% of all surgical procedures occur in the poorest countries where over a third of the world's population lives (Meara et al. in Surgery 158(1):3-6, 2015). Mobile surgical units like the Cinterandes Foundation endeavor to bring surgical care directly to these communities who otherwise would lack access to safe surgery. This study examines the barriers patients encounter in seeking surgical care in rural communities of Ecuador and their impressions on how mobile surgery addresses such barriers...
May 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28315457/anticonvulsant-activity-and-acute-neurotoxic-profile-of-achyranthes-aspera-linn
#17
Dinesh Y Gawande, Dmitry Druzhilovsky, Raghbir Chand Gupta, Vladimir Poroikov, Rajesh Kumar Goel
ETHNOPHARMACOLOGICAL RELEVANCE: Root powder of Achyranthes aspera Linn. (A. aspera) belongs to family Amaranthaceae is used in Indian traditional medicine for the management of epilepsy and its efficacy is widely acclaimed among the different rural communities. AIM OF THE STUDY: The present study was aimed to establish the possible anticonvulsant effect of A. aspera methanolic root extract using acute anticonvulsant models and to evaluate the acute toxicity and neurotoxic potential A...
March 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28283722/fanconi-anemia-correlating-central-nervous-system-malformations-and-genetic-complementation-groups
#18
Benjamin A Johnson-Tesch, Rakhee S Gawande, Lei Zhang, Margaret L MacMillan, David R Nascene
BACKGROUND: Congenital central nervous system abnormalities in children with Fanconi anemia are poorly characterized, especially with regard to specific genetic complementation groups. OBJECTIVE: To characterize the impact of genetic complementation groups on central nervous system anatomy. MATERIALS AND METHODS: Through chart review we identified 36 patients with Fanconi anemia with available brain MRIs at the University of Minnesota (average age, 11...
March 10, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28265889/the-need-for-new-ars-moriendi-being-mortal-medicine-and-what-matters-in-the-end-by-atul-gawande-metropolitan-books-henry-holt-and-company-new-york-2014-isbn-978-0-8050-9515-9-pp-282-26-00-hardcover
#19
https://www.readbyqxmd.com/read/28265062/selection-of-dna-aptamers-with-two-modified-bases
#20
Bharat N Gawande, John C Rohloff, Jeffrey D Carter, Ira von Carlowitz, Chi Zhang, Daniel J Schneider, Nebojsa Janjic
The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity than protein-based ligands, limiting their versatility. The introduction of novel functional groups at just one of the four bases in modified aptamers has recently led to dramatic improvement in the success rate of identifying nucleic acid ligands to protein targets. Here we explore the benefits of additional enhancement in physicochemical diversity by selecting modified DNA aptamers that contain amino-acid-like modifications on both pyrimidine bases...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
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