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https://www.readbyqxmd.com/read/29753069/engineering-a-short-aldolase-based-pathway-for-r-1-3-butanediol-production-in-escherichia-coli
#1
Kayla Nemr, Jonas E N Müller, Jeong Chan Joo, Pratish Gawand, Ruhi Choudhary, Burton Mendonca, Shuyi Lu, Xiuyan Yu, Alexander F Yakunin, Radhakrishnan Mahadevan
Microbial processes can produce a wide range of compounds; however, producing complex and long chain hydrocarbons remains a challenge. Aldol condensation offers a direct route to synthesize these challenging chemistries and can be catalyzed by microbes using aldolases. Deoxyribose-5-phosphate aldolase (DERA) condenses aldehydes and/or ketones to β-hydroxyaldehydes, which can be further converted to value-added chemicals such as a precursor to cholesterol-lowering drugs. Here, we implement a short, aldolase-based pathway in Escherichia coli to produce (R)-1,3-BDO from glucose, an essential component of pharmaceutical products and cosmetics...
May 9, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29731565/t-cell-lymphoma-of-oral-cavity-a-rare-entity
#2
Preethi Sharma, Madhuri Gawande, Minal Chaudhary, Rajul Ranka
Lymphomas are heterogeneous malignancies of the lymphatic system characterized by lymphoid cell proliferation. They can broadly be divided into Hodgkin's lymphoma (HL) and non-HL (NHL). NHL can originate from B, T or natural killer lymphocytes. Extranodal presentation of T-cell NHL is extremely rare and is often seen in immunocompromised individuals. Here, we report a rare case of T-cell lymphoma of the oral cavity in a 13-year-old patient. The patient was diagnosed to have T-cell lymphoma on the basis of biopsy and immunohistochemistry and was referred to the oral surgery department for definite treatment...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29728543/oral-manifestations-in-diabetic-and-nondiabetic-chronic-renal-failure-patients-receiving-hemodialysis
#3
Ravi Dande, Amol R Gadbail, Sheetal Sarode, Mugdha P Mankar Gadbail, Shailesh M Gondivkar, Madhuri Gawande, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
Aim: To assess the prevalence of oral findings in diabetic and nondiabetic chronic renal failure (CRF) patients receiving hemodialysis (HD). Materials and methods: This study was conducted on 144 CRF patients undergoing HD therapy. They were further classified into diabetic and nondiabetic groups and also according to the duration of CRF. An oral examination was performed, searching for CRF-associated oral findings, along with due considerations to duration of CRF. Results: The oral manifestations were found to be higher in diabetic CRF patients (97...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29673159/iron-oxide-cobalt-nanocatalyst-for-o-tert-boc-protection-and-o-arylation-of-phenols
#4
Vilas B Gade, Anandarup Goswami, Rajender S Varma, Sharad N Shelke, Manoj B Gawande
Efficient and general protocols for the O - tert -boc protection and O -arylation of phenols were developed in this paper using a recyclable magnetic Fe₃O₄-Co₃O₄ nanocatalyst (Nano-Fe-Co), which is easily accessible via simple wet impregnation techniques in aqueous mediums from inexpensive precursors. The results showed the catalysts were well characterized by XRD (X-ray Diffraction), ICP-AES (Inductive Coupled Plasma Atomic Emission Spectroscopy), TEM (Transmission Electron Microscopy), TOF-SIMS (Time-Of-Flight Secondary Ion Mass Spectrometry) and XPS (X-ray Photoelectron Spectroscopy)...
April 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29658817/racial-and-ethnic-differences-in-advance-care-planning-results-of-a-statewide-population-based-survey
#5
Melissa A Clark, Sharina D Person, Anna Gosline, Atul A Gawande, Susan D Block
BACKGROUND: Few studies have focused on racial and ethnic differences in advance care planning other than advance directives among population-based samples of adults across the lifespan. METHODS: Using data from a statewide random-digit dial telephone survey of adults 18 years or older (n = 1851), we investigated racial and ethnic differences in (1) designation of a healthcare agent (HCA); and (2) communication of goals, values, and preferences for end-of-life care with healthcare providers, a HCA, or other family members and friends...
April 16, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29655883/evaluating-surgical-coaching-a-mixed-methods-approach-reveals-more-than-surveys-alone
#6
Laura M Mazer, Yue-Yung Hu, Alexander F Arriaga, Caprice C Greenberg, Stuart R Lipsitz, Atul A Gawande, Douglas S Smink, Steven J Yule
OBJECTIVE: Traditionally, surgical educators have relied upon participant survey data for the evaluation of educational interventions. However, the ability of such subjective data to completely evaluate an intervention is limited. Our objective was to compare resident and attending surgeons' self-assessments of coaching sessions from surveys with independent observations from analysis of intraoperative and postoperative coaching transcripts. DESIGN: Senior residents were video-recorded operating...
April 11, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29625431/the-risks-to-patient-safety-from-health-system-expansions
#7
Susan Haas, Atul Gawande, Mark E Reynolds
No abstract text is available yet for this article.
April 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29608439/quantitative-analysis-of-the-benefits-and-risk-of-thyroid-nodule-evaluation-in-patients-%C3%A2-70-years-old
#8
Zhihong Wang, Chirag M Vyas, Olivia Van Benschoten, Matt A Nehs, Francis D Moore, Ellen Marqusee, Jeffrey F Krane, Matthew I Kim, Howard T Heller, Atul A Gawande, Mary C Frates, Peter M Doubilet, Gerard M Doherty, Nancy L Cho, Edmund S Cibas, Carol B Benson, Justine A Barletta, Ann Marie Zavacki, P Reed Larsen, Erik K Alexander, Trevor E Angell
BACKGROUND: In older patients, thyroid nodules are frequently detected and referred for evaluation, though usually prove to be benign disease or low-risk cancer. Therefore, management should be guided not solely by malignancy risk, but also by the relative risks of any intervention. Unfortunately, few such data are available for patients ≥70 years old. METHODS: All consecutive patients ≥70 years old assessed by ultrasound (US) and fine-needle aspiration (FNA) between 1995 and 2015 were analyzed...
April 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29602875/update-of-marx-delaney-et-al-improving-adherence-to-essential-birth-practices-using-the-who-safe-childbirth-checklist-with-peer-coaching-experience-from-60-public-health-facilities-in-uttar-pradesh-india
#9
Megan Marx Delaney, Pinki Maji, Tapan Kalita, Nabihah Kara, Darpan Rana, Krishan Kumar, Jenny Masoinneuve, Simon Cousens, Atul A Gawande, Vishwajeet Kumar, Bhala Kodkany, Narender Sharma, Rajiv Saurastri, Vinay Pratap Singh, Lisa R Hirschhorn, Katherine Ea Semrau, Rebecca Firestone
No abstract text is available yet for this article.
March 21, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29602874/update-of-kara-et-al-the-betterbirth-program-pursuing-effective-adoption-and-sustained-use-of-the-who-safe-childbirth-checklist-through-coaching-based-implementation-in-uttar-pradesh-india
#10
Nabihah Kara, Rebecca Firestone, Tapan Kalita, Atul A Gawande, Vishwajeet Kumar, Bhala Kodkany, Rajiv Saurastri, Vinay Pratap Singh, Pinki Maji, Ami Karlage, Lisa R Hirschhorn, Katherine Ea Semrau
No abstract text is available yet for this article.
March 21, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29578910/multisource-evaluation-of-surgeon-behavior-is-associated-with-malpractice-claims
#11
Janaka Lagoo, William R Berry, Kate Miller, Brandon J Neal, Luke Sato, Keith D Lillemoe, Gerard M Doherty, James R Kasser, Elliot L Chaikof, Atul A Gawande, Alex B Haynes
OBJECTIVE: We merged direct, multisource, and systematic assessments of surgeon behavior with malpractice claims, to analyze the relationship between surgeon 360-degree reviews and malpractice history. BACKGROUND: Previous work suggests that malpractice claims are associated with a poor physician-patient relationship, which is likely related to behaviors captured by 360-degree review. We hypothesize that 360-degree review results are associated with malpractice claims...
March 23, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29520656/reasons-associated-with-total-thyroidectomy-as-initial-surgical-management-of-an-indeterminate-thyroid-nodule
#12
Trevor E Angell, Chirag M Vyas, Justine A Barletta, Edmund S Cibas, Nancy L Cho, Gerard M Doherty, Atul A Gawande, Brooke E Howitt, Jeffrey F Krane, Ellen Marqusee, Kyle C Strickland, Erik K Alexander, Francis D Moore, Matthew A Nehs
BACKGROUND: Diagnostic hemithyroidectomy (HT) is the most widely recommended surgical procedure for a nodule with indeterminate cytology; however, additional details may make initial total thyroidectomy (TT) preferable. We sought to identify patient-specific factors (PSFs) associated with initial TT in patients with indeterminate thyroid nodules. METHODS: Retrospective analysis of all patients with a thyroid nodule ≥ 1 cm and initial cytology of atypia of undetermined significance or suspicious for follicular neoplasm between 2012 and 2015 who underwent thyroidectomy...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29484563/4d-ct-is-superior-to-ultrasound-and-sestamibi-for-localizing-recurrent-parathyroid-disease
#13
Moska Hamidi, Michael Sullivan, George Hunter, Leena Hamberg, Nancy L Cho, Atul A Gawande, Gerard M Doherty, Francis D Moore, Matthew A Nehs
BACKGROUND: Recurrent primary hyperparathyroidism (PHPT) presents a diagnostic challenge in localizing a hyperfunctioning gland. Although several imaging modalities are available for preoperative localization, 4D-CT is increasingly utilized for its ability to locate both smaller and previously unlocalized lesions. Currently, there is a paucity of data evaluating the utility of 4D-CT in the reoperative setting compared with ultrasound (US) and sestamibi. We aimed to determine the sensitivity of 4D-CT in localizing parathyroid adenomas in recurrent or persistent PHPT...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29391728/influence-of-risk-factors-on-patients-suffering-from-potentially-malignant-disorders-and-oral-cancer-a-case-control-study
#14
Vidya Kadashetti, K M Shivakumar, Minal Chaudhary, Swati Patil, Madhuri Gawande, Alka Hande
Background: Tobacco use can alone lead to death worldwide, especially in developing and underdeveloped countries. China and Brazil are the world's largest producer of tobacco. India holds the third place in producing, and it is the fourth largest consumer of tobacco and its products in the world. Objectives: A case-control study was carried out to assess the influence of risk factors on patients with potentially malignant disorders (PMD) and oral cancer. Materials and Methods: Fifty cases diagnosed with PMD and oral cancer patients were selected for the study...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29382886/an-efficient-copper-based-magnetic-nanocatalyst-for-the-fixation-of-carbon-dioxide-at-atmospheric-pressure
#15
Rakesh Kumar Sharma, Rashmi Gaur, Manavi Yadav, Anandarup Goswami, Radek Zbořil, Manoj B Gawande
In the last few decades, the emission of carbon dioxide (CO2 ) in the environment has caused havoc across the globe. One of the most promising strategies for fixation of CO2 is the cycloaddition reaction between epoxides and CO2 to produce cyclic carbonates. For the first time, we have fabricated copper-based magnetic nanocatalyst and have applied for the CO2 fixation. The prepared catalyst was thoroughly characterized using various techniques including XRD, FT-IR, TEM, FE-SEM, XPS, VSM, ICP-OES and elemental mapping...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29362928/is-amalgamated-ligno-bupivacaine-an-answer-to-complicated-minor-oral-surgical-anesthesia-a-randomized-split-mouth-double-blind-clinical-trial
#16
Akshay Mishra, Monica Mahajan, Chandrashekhar Bande, Ajit Joshi, Mayur Gawande, M K Gupta
PURPOSE: The purpose of this study was to find a suitable anesthetic combination for complicated and protracted minor oral surgical procedures. METHODS: Fifty patients with bilaterally impacted deep-seated mandibular third molars were included in this study and randomly divided on the basis of anesthetic used into two groups. Group A received 2% lignocaine with 1:200,000 adrenaline while in group B, amalgamated mixture of 2% lignocaine and 0.5% bupivacaine was used...
March 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29327891/health-insurance-coverage-and-health
#17
Benjamin D Sommers, Atul A Gawande, Katherine Baicker
No abstract text is available yet for this article.
November 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29237963/analysis-of-factors-affecting-initial-cyclosporine-level-and-its-impact-on-post-transplant-outcomes-in-acute-leukemia
#18
Alok Gupta, Sachin Punatar, Jayant Gawande, Libin Mathew, Sadhana Kannan, Navin Khattry
BACKGROUND: Trough cyclosporine (CsA) blood level can influence incidence of graft-versus-host disease (GVHD) and relapse in patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplant (HSCT). We sought to determine factors affecting initial trough CsA level (CsA-1) and its impact on transplant outcome in acute leukemia. MATERIALS AND METHODS: Seventy-seven patients underwent HSCT for acute leukemia between January 2008 and March 2013 and were included...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29236628/outcomes-of-a-coaching-based-who-safe-childbirth-checklist-program-in-india
#19
RANDOMIZED CONTROLLED TRIAL
Katherine E A Semrau, Lisa R Hirschhorn, Megan Marx Delaney, Vinay P Singh, Rajiv Saurastri, Narender Sharma, Danielle E Tuller, Rebecca Firestone, Stuart Lipsitz, Neelam Dhingra-Kumar, Bhalachandra S Kodkany, Vishwajeet Kumar, Atul A Gawande
BACKGROUND: The prevalence of facility-based childbirth in low-resource settings has increased dramatically during the past two decades, yet gaps in the quality of care persist and mortality remains high. The World Health Organization (WHO) Safe Childbirth Checklist, a quality-improvement tool, promotes systematic adherence to practices that have been associated with improved childbirth outcomes. METHODS: We conducted a matched-pair, cluster-randomized, controlled trial in 60 pairs of facilities across 24 districts of Uttar Pradesh, India, testing the effect of the BetterBirth program, an 8-month coaching-based implementation of the Safe Childbirth Checklist, on a composite outcome of perinatal death, maternal death, or maternal severe complications within 7 days after delivery...
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29179954/universal-health-coverage-and-intersectoral-action-for-health-key-messages-from-disease-control-priorities-3rd-edition
#20
REVIEW
Dean T Jamison, Ala Alwan, Charles N Mock, Rachel Nugent, David Watkins, Olusoji Adeyi, Shuchi Anand, Rifat Atun, Stefano Bertozzi, Zulfiqar Bhutta, Agnes Binagwaho, Robert Black, Mark Blecher, Barry R Bloom, Elizabeth Brouwer, Donald A P Bundy, Dan Chisholm, Alarcos Cieza, Mark Cullen, Kristen Danforth, Nilanthi de Silva, Haile T Debas, Peter Donkor, Tarun Dua, Kenneth A Fleming, Mark Gallivan, Patricia J Garcia, Atul Gawande, Thomas Gaziano, Hellen Gelband, Roger Glass, Amanda Glassman, Glenda Gray, Demissie Habte, King K Holmes, Susan Horton, Guy Hutton, Prabhat Jha, Felicia M Knaul, Olive Kobusingye, Eric L Krakauer, Margaret E Kruk, Peter Lachmann, Ramanan Laxminarayan, Carol Levin, Lai Meng Looi, Nita Madhav, Adel Mahmoud, Jean Claude Mbanya, Anthony Measham, María Elena Medina-Mora, Carol Medlin, Anne Mills, Jody-Anne Mills, Jaime Montoya, Ole Norheim, Zachary Olson, Folashade Omokhodion, Ben Oppenheim, Toby Ord, Vikram Patel, George C Patton, John Peabody, Dorairaj Prabhakaran, Jinyuan Qi, Teri Reynolds, Sevket Ruacan, Rengaswamy Sankaranarayanan, Jaime Sepúlveda, Richard Skolnik, Kirk R Smith, Marleen Temmerman, Stephen Tollman, Stéphane Verguet, Damian G Walker, Neff Walker, Yangfeng Wu, Kun Zhao
The World Bank is publishing nine volumes of Disease Control Priorities, 3rd edition (DCP3) between 2015 and 2018. Volume 9, Improving Health and Reducing Poverty, summarises the main messages from all the volumes and contains cross-cutting analyses. This Review draws on all nine volumes to convey conclusions. The analysis in DCP3 is built around 21 essential packages that were developed in the nine volumes. Each essential package addresses the concerns of a major professional community (eg, child health or surgery) and contains a mix of intersectoral policies and health-sector interventions...
November 24, 2017: Lancet
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