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Gawande

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https://www.readbyqxmd.com/read/28202370/to-evaluate-the-role-of-platelet-rich-plasma-in-healing-of-acute-diaphyseal-fractures-of-the-femur
#1
Roop Singh, Rajesh Rohilla, Jeetesh Gawande, Paramjit Kumar Sehgal
PURPOSE: New research is focusing on the use of autologous growth factors to increase the effect of bone fracture healing while decreasing the amount of healing time for the patient. Platelets have been demonstrated to be the natural storage vessel for several growth factors and cytokines that promote blood coagulation, tissue repair, and the process of bone mineralization. The present study aims to evaluate the role of platelet-rich plasma (PRP) in healing of acute femoral shaft fractures radiologically...
January 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28137324/heteroplasmy-due-to-coexistence-of-mtcoi-haplotypes-from-different-lineages-of-the-thrips-tabaci-cryptic-species-group
#2
S J Gawande, S Anandhan, A A Ingle, Alana Jacobson, R Asokan
Heteroplasmy is the existence of multiple mitochondrial DNA haplotypes within the cell. Although the number of reports of heteroplasmy is increasing for arthropods, the occurrence, number of variants, and origins are not well studied. In this research, the occurrence of heteroplasmy was investigated in Thrips tabaci, a putative species complex whose lineages can be distinguished by their mitochondrial DNA haplotypes. The results from this study showed that heteroplasmy was due to the occurrence of mitochondrial cytochrome oxydase I (mtCOI) haplotypes from two different T...
January 31, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28129456/oral-squamous-cell-carcinoma-in-the-background-of-oral-submucous-fibrosis-is-a-distinct-clinico-pathological-entity-with-better-prognosis
#3
Amol Ramchandra Gadbail, Minal Chaudhary, Madhuri Gawande, Alka Hande, Sachin Sarode, Satyjit Ashok Tekade, Sheetal Korde, Prajakta Zade, Rahul Bhowate, Rajiv Borle, Swati Patil
BACKGROUND: The aim of this study was to compare the clinicopathological features of oral squamous cell carcinoma in the background of oral submucous fibrosis (OSCC-OSMF) and oral squamous cell carcinoma (OSCC). METHODS: 217 cases of OSCC were retrieved from achieves for the analysis.OSCC-OSMF cases were segregated on the basis of history and clinico-pathological parameters. RESULTS: The study included 217 patients of which 112 had OSCC and 105 OSCC-OSMF...
January 27, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28096608/effect-of-aegle-marmelos-and-murraya-koenigii-in-treatment-of-delayed-pubertal-buffaloes-heifers
#4
Mohan M Baitule, A P Gawande, Umesh Kumar, S K Sahatpure, Manoj S Patil, Mansi M Baitule
AIM: This study aims to study the estrus induction, ovulation, and conception rate of delayed puberty in buffaloes heifers by feeding a herbal plants Aegle marmelos (bael/bili/bhel leaf) and Murraya koenigii (Curry leaf). MATERIALS AND METHODS: Totally, 24 buffalo heifers with delayed puberty were selected for the present study and divided randomly in four equal groups (n=6). Before experiment, all animals were dewormed with albendazole at 10 mg/kg body weight to prevent them from the stress of parasitism...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28067675/it-s-time-to-adopt-electronic-prescriptions-for-opioids
#5
Atul A Gawande
No abstract text is available yet for this article.
January 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28035800/in-situ-generation-of-pd-pt-core-shell-nanoparticles-on-reduced-graphene-oxide-pd-pt-rgo-using-microwaves-applications-in-dehalogenation-reactions-and-reduction-of-olefins
#6
Anandarup Goswami, Anuj K Rathi, Claudia Aparicio, Ondrej Tomanec, Martin Petr, Radka Pocklanova, Manoj B Gawande, Rajender S Varma, Radek Zboril
Core-shell nanocatalysts are a distinctive class of nanomaterials with varied potential applications in view of their unique structure, composition-dependent physicochemical properties, and promising synergism among the individual components. A one-pot microwave (MW)-assisted approach is described to prepare the reduced graphene oxide (rGO)-supported Pd-Pt core-shell nanoparticles, (Pd@Pt/rGO); spherical core-shell nanomaterials (∼95 nm) with Pd core (∼80 nm) and 15 nm Pt shell were nicely distributed on the rGO matrix in view of the choice of reductant and reaction conditions...
January 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28017809/prevalence-of-contralateral-tumors-in-patients-with-follicular-variant-of-papillary-thyroid-cancer
#7
Michael C Sullivan, Paul H Graham, Erik K Alexander, Daniel T Ruan, Matthew A Nehs, Atul A Gawande, Francis D Moore, Brooke E Howitt, Kyle C Strickland, Jeffrey F Krane, Justine A Barletta, Nancy L Cho
BACKGROUND: Thyroid lobectomy alone is being performed increasingly for patients with encapsulated follicular variant of papillary thyroid carcinoma (fvPTC). However, the prevalence of contralateral disease in these patients is unknown. We investigated the presence of synchronous disease in fvPTC to improve decision making about the extent of surgical resection and need for surveillance. STUDY DESIGN: We performed a retrospective review of patients who underwent thyroid surgery from October 2009 to February 2013 with a diagnosis of fvPTC as their primary lesion...
December 23, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28006753/agmatine-ameliorates-adjuvant-induced-arthritis-and-inflammatory-cachexia-in-rats
#8
Brijesh G Taksande, Dinesh Y Gawande, Chandrabhan T Chopde, Milind J Umekar, Nandkishor R Kotagale
The present study investigated the pharmacological effect of agmatine in Complete Freud Adjuvant (CFA) induced arthritis and cachexia in rats. The rats were injected with CFA (0.1ml/rat) to induced symptoms of arthritis. Day 8 onwards of CFA administration, rats were injected daily with agmatine for next 7days, and arthritis score, body weights and food intake were monitored daily (g). Since cachexia is known to produce severe inflammation, malnutrition and inhibition of albumin gene expression, we have also monitored the total proteins, albumin, TNF-α and IL-6 levels in arthritic rats and its modulation by agmatine...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27973648/complementing-operating-room-teaching-with-video-based-coaching
#9
Yue-Yung Hu, Laura M Mazer, Steven J Yule, Alexander F Arriaga, Caprice C Greenberg, Stuart R Lipsitz, Atul A Gawande, Douglas S Smink
Importance: Surgical expertise demands technical and nontechnical skills. Traditionally, surgical trainees acquired these skills in the operating room; however, operative time for residents has decreased with duty hour restrictions. As in other professions, video analysis may help maximize the learning experience. Objective: To develop and evaluate a postoperative video-based coaching intervention for residents. Design, Setting, and Participants: In this mixed methods analysis, 10 senior (postgraduate year 4 and 5) residents were videorecorded operating with an attending surgeon at an academic tertiary care hospital...
December 14, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27973617/quantifying-geographic-variation-in-health-care-outcomes-in-the-united-states-before-and-after-risk-adjustment
#10
Barry L Rosenberg, Joshua A Kellar, Anna Labno, David H M Matheson, Michael Ringel, Paige VonAchen, Richard I Lesser, Yue Li, Justin B Dimick, Atul A Gawande, Stefan H Larsson, Hamilton Moses
BACKGROUND: Despite numerous studies of geographic variation in healthcare cost and utilization at the local, regional, and state levels across the U.S., a comprehensive characterization of geographic variation in outcomes has not been published. Our objective was to quantify variation in US health outcomes in an all-payer population before and after risk-adjustment. METHODS AND FINDINGS: We used information from 16 independent data sources, including 22 million all-payer inpatient admissions from the Healthcare Cost and Utilization Project (which covers regions where 50% of the U...
2016: PloS One
https://www.readbyqxmd.com/read/27972901/is-there-a-difference-in-perception-and-practice-in-pharmacological-management-of-schizophrenia-a-cross-sectional-survey-in-india
#11
P R Gundugurti, R Nagpal, A S Sheth, P Narang, S J Gawande, S Sharma, J Klug
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27923401/effectiveness-of-the-who-safe-childbirth-checklist-program-in-reducing-severe-maternal-fetal-and-newborn-harm-in-uttar-pradesh-india-study-protocol-for-a-matched-pair-cluster-randomized-controlled-trial
#12
Katherine E A Semrau, Lisa R Hirschhorn, Bhala Kodkany, Jonathan M Spector, Danielle E Tuller, Gary King, Stuart Lipsitz, Narender Sharma, Vinay Pratap Singh, Bharath Kumar, Neelam Dhingra-Kumar, Rebecca Firestone, Vishwajeet Kumar, Atul A Gawande
BACKGROUND: Effective, scalable strategies to improve maternal, fetal, and newborn health and reduce preventable morbidity and mortality are urgently needed in low- and middle-income countries. Building on the successes of previous checklist-based programs, the World Health Organization (WHO) and partners led the development of the Safe Childbirth Checklist (SCC), a 28-item list of evidence-based practices linked with improved maternal and newborn outcomes. Pilot-testing of the Checklist in Southern India demonstrated dramatic improvements in adherence by health workers to essential childbirth-related practices (EBPs)...
December 7, 2016: Trials
https://www.readbyqxmd.com/read/27775348/synthesis-of-d-galactosamine-and-d-allosamine-derivatives-via-a-microwave-assisted-preparation-of-1-6-anhydroglucosamine
#13
Vijay M Dhurandhare, Yuh-Sheng Wen, Sachin D Gawande, Pin-Hsuan Liao, Cheng-Chung Wang
We report a microwave-assisted intramolecular anomeric protection (iMAP) of glucosamine, which facilitates concise transformation of 1,6-anhydroglucosamine into 1,6-anhydrogalactosamine and 1,6-anhydroallosamine. The iMAP simultaneously obviates both the O1 and O6 protection, and the differentiation between O3 and O4 can be well-controlled by the N2 functionality because of the hydrogen bonding between N2 and O4. Epimerization of O4 afforded the galactosamine derivative and that of O3 yielded allosamine.
November 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27741416/utility-of-superiorly-based-masseter-muscle-flap-for-postablative-retromaxillary-reconstruction
#14
Chandrashekhar R Bande, Akshay Mishra, M K Gupta, Manu Goel, Mayur J Gawande
PURPOSE: Resections in the posterior component of the oral cavity usually lead to severe functional compromise and lower quality of life for patients. Notable advances in reconstruction of the posterior part of the mouth and of the oropharynx have occurred in recent decades. The anatomic and physiologic rehabilitation of the defect to a reasonable outcome with low morbidity and mortality remains the founding basis of any surgical reconstruction, which also holds true for oral oropharyngeal and retromaxillary reconstructions...
January 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27689252/clinical-sonographic-and-pathological-characteristics-of-ras-positive-versus-braf-positive-thyroid-carcinoma
#15
Sujay Kakarmath, Howard T Heller, Caroline A Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta, Neal I Lindeman, Mary C Frates, Carol B Benson, Atul A Gawande, Nancy L Cho, Matthew Nehs, Francis D Moore, Ellen Marqusee, Mathew I Kim, P Reed Larsen, Norra Kwong, Trevor E Angell, Erik K Alexander
CONTEXT: Mutations in the BRAF and RAS oncogenes are responsible for most well-differentiated thyroid cancer. Yet, our clinical understanding of how BRAF-positive and RAS-positive thyroid cancers differ is incomplete. OBJECTIVE: We correlated clinical, radiographic, and pathological findings from patients with thyroid cancer harboring a BRAF or RAS mutation. DESIGN: Prospective cohort study. SETTING: Academic, tertiary care hospital...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27683297/immediate-versus-delayed-aggressive-physical-therapy-following-buccal-fat-pad-interposition-in-oral-submucous-fibrosis-a-prospective-study-in-central-india
#16
Chandrashekhar Bande, Pawan Dawane, M K Gupta, Mayur Gawande, Vijay Rode
PURPOSE: Oral submucous fibrosis is a disease of an Indian subcontinent with obscure aetiology and poorly treated with varying signs and symptoms. OSMF occurs at any age but is most commonly seen in teenagers and adults in the age ranging between 16 and 35 years. A number of surgical treatments have been used for the treatment of oral submucous fibrosis with unpredictable results. PATIENTS AND METHOD: In this study, 220 patients were randomly divided into two groups with mouth opening less than 16 mm and evaluated with immediate and delayed aggressive physiotherapy with buccal fat pad interposition after fibrotomy...
December 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27664881/postoperative-acute-care-use-after-freestanding-ambulatory-surgery
#17
George Molina, Bridget A Neville, Stuart R Lipsitz, Lorri Gibbons, Ashley Kay Childers, Atul A Gawande, William R Berry, Alex B Haynes
BACKGROUND: Surgical procedures in the United States are increasingly performed in the ambulatory setting, including freestanding ambulatory surgery centers (ASCs). However, there is a lack of research and tracking of surgical outcomes in this setting. MATERIALS AND METHODS: We analyzed data from a state all-payer claims database to produce a retrospective cohort study on the rate of acute care use (emergency department [ED] visits and inpatient admissions) within 7 d after operations performed in freestanding ASCs in South Carolina...
October 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27642053/cluster-randomized-trial-to-evaluate-the-impact-of-team-training-on-surgical-outcomes
#18
A Duclos, J L Peix, V Piriou, P Occelli, A Denis, S Bourdy, M J Carty, A A Gawande, F Debouck, C Vacca, J C Lifante, C Colin
BACKGROUND: The application of safety principles from the aviation industry to the operating room has offered hope in reducing surgical complications. This study aimed to assess the impact on major surgical complications of adding an aviation-based team training programme after checklist implementation. METHODS: A prospective parallel-group cluster trial was undertaken between September 2011 and March 2013. Operating room teams from 31 hospitals were assigned randomly to participate in a team training programme focused on major concepts of crew resource management and checklist utilization...
December 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27580484/economic-impact-of-surgical-complications-on-hospitals
#19
Barry Rosenberg, Bennett Lane, Atul Gawande
No abstract text is available yet for this article.
November 1, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27579301/a-sustainable-and-efficient-synthesis-of-benzyl-phosphonates-using-peg-ki-catalytic-system
#20
Shamrao Disale, Sandip Kale, George Abraham, Sandeep Kahandal, Ashish N Sawarkar, Manoj B Gawande
An efficient and expedient protocol for the synthesis of benzyl phosphonates using KI/K2CO3 as a catalytic system and PEG-400 as benign solvent has been developed. The reaction proceeds smoothly at room temperature achieving excellent selectivity and yield of the corresponding products. The combination of PEG-400, KI, and K2CO3 in this reaction avoids the need of volatile/toxic organic solvents and reactive alkali metals or metal nanoparticles/hydrides. We believe that this benign combination (PEG-400 and KI) could be used for other related organic transformations...
2016: Frontiers in Chemistry
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