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serum ferritin level

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https://www.readbyqxmd.com/read/28649081/soluble-transferrin-receptor-ferritin-index-in-pakistani-population
#1
Faiza Alam, Nabeel Ashraf, Ramsha Kashif, Hashaam Arshad, Syeda Sadia Fatima
Inflammation affects the reliability of ferritin. The serum level of transferrin receptor protein (sTfR) represents true demand of iron in the body. This study attempts to identify levels of sTfR and correlate the trends of sTfR/ferritin index with BMI in the population of Karachi. 132 gender matched volunteers between the ages of 20-60 years were recruited for this cross-sectional study. BMI was calculated using the formula: (weight in kg / height in m2). Following groups were made according to South Asian criteria of BMI; Group A: normal weight (18...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28648203/high-levels-of-both-serum-gamma-glutamyl-transferase-and-alkaline-phosphatase-are-independent-preictors-of-mortality-in-patients-with-stage-4-5-chronic-kidney-disease
#2
Fernando Caravaca-Fontán, Lilia Azevedo, Miguel Ángel Bayo, Boris Gonzales-Candia, Enrique Luna, Francisco Caravaca
INTRODUCTION: High serum gamma-glutamyl transferase (GGT) levels are associated with increased mortality in the general population. However, this association has scarcely been investigated in patients with chronic kidney disease (CKD). This study aims to investigate the clinical characteristics of CKD patients with abnormally elevated serum GGT, and its value for predicting mortality. MATERIAL AND METHODS: Retrospective observational study in a population cohort of adults with stage 4-5 CKD not yet on dialysis...
May 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28645014/the-association-between-serum-ferritin-levels-and-the-risk-of-new-onset-type-2-diabetes-mellitus-a-10-year-follow-up-of-the-chinese-multi-provincial-cohort-study
#3
Shen Gao, Dong Zhao, Yue Qi, Miao Wang, Fan Zhao, Jiayi Sun, Jing Liu
AIMS: To investigate the association of serum ferritin levels and ferritin level changes with the 10-year risk of new-onset type 2 diabetes mellitus (T2DM). METHODS: Among 2359 subjects without T2DM at baseline in 2002, 1956 subjects were re-examined in 2007, and 1660 subjects were invited to be re-examined in 2012. Serum ferritin (ng/ml) levels were measured by latex-enhanced turbidimetric immunoassay. Five-year serum ferritin changes were categorized into four groups using the median as the cut-off point...
June 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28641663/-expression-changes-of-hepcidin-and-ferroportin-1-in-murine-model-of-iron-overload
#4
Jing-Wen Wang, Lu-Hong Xu, Xi Yao, Jian-Pei Fang
OBJECTIVE: To investigate the changes of hepcidin and ferropotin 1 expression in murine model of iron overload. METHODS: The murine model of iron overload was established, C57BL/6 mice were injected with iron dextran intraperitoneally (10 mg) every 3 days for 4 weeks. Blood routine, serum ferritin and pathological sections were tested at the appointed time-point respectively (before iron injection, 2 weeks and 4 weeks after treatment of iron injection). The serum hepcidin was assayed by enzyme-linked immunosorbent method...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28636169/a-novel-double-nucleotide-variant-in-the-ferritin-l-iron-responsive-element-in-a-finnish-patient-with-hereditary-hyperferritinaemia-cataract-syndrome
#5
Roosa-Maria Mattila, Annele Sainio, Marketta Järveläinen, Juha Pursiheimo, Hannu Järveläinen
PURPOSE: To present a novel Finnish double nucleotide variant in the iron-responsive element (IRE) of the ferritin L-chain gene (FTL) leading to hyperferritinaemia-cataract syndrome (HHCS). METHODS: Genomic DNA extracted from peripheral blood leucocytes and synthetized with three different primers flanking the IRE in the FTL 5'-untranslated region of the FTL was used in polymerase chain reaction (PCR). Thereafter, Sanger sequencing was performed on the 487-bp and 602-bp PCR amplification products with specific primers to reveal FTL IRE mutations...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28632695/serum-ceruloplasmin-and-striatal-dopamine-transporter-density-in-parkinson-disease-comparison-with-123i-fp-cit-spect
#6
Yoo Sung Song, Jong-Min Kim, Kyeong Joon Kim, Ji Young Yun, Sang Eun Kim
PURPOSE: In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin-along with its related serum markers- and striatal presynaptic dopaminergic denervation measured with I-FP-CIT SPECT. METHODS: We analyzed a total of 141 de novo patients divided into 2 groups: the PD group (107 patients with PD) and the disease control group (34 patients with vascular pseudoparkinsonism, essential tremor, or drug-induced parkinsonism)...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28622367/role-of-serum-ferritin-level-on-overall-survival-in-patients-with-myelodysplastic-syndromes-results-of-a-meta-analysis-of-observational-studies
#7
Claudia Pileggi, Maddalena Di Sanzo, Valentina Mascaro, Maria Grazia Marafioti, Francesco Saverio Costanzo, Maria Pavia
BACKGROUND: The role of serum ferritin (SF) as a prognostic factor has been analyzed in patients with myelodysplastic syndromes (MDS) who have undergone hematopoietic stem cell transplantation (HSCT), but the prognostic role of elevated SF levels is still controversial in lower risk MDS patients. Therefore, we performed a meta-analysis of all available published literature to evaluate whether elevated SF levels are associated with a worse overall survival (OS) among patients with low risk MDS...
2017: PloS One
https://www.readbyqxmd.com/read/28620614/postmenopausal-iron-overload-exacerbated-bone-loss-by-promoting-the-degradation-of-type-i-collagen
#8
Qian Cheng, Xiaofei Zhang, Jun Jiang, Guoyang Zhao, Yin Wang, Youjia Xu, Ximing Xu, Haile Ma
117 postmenopausal women were divided into Normal, Bone loss (BL), and Osteoporosis group. Compared with Normal group (120.96 ± 43.18 μg/L), the serum ferritin (Fer) in BL (223.37 ± 130.27 μg/L) and Osteoporosis group (307.50 ± 161.48 μg/L) was significantly increased (p < 0.05). Fer level was negatively correlated with BMD (p < 0.01). TRACP levels in Osteoporosis group (4.37 ± 1.69 U/L) were significantly higher than Normal group (4.10 ± 1.60 U/L, p < 0.05). ALP levels in Osteoporosis group (112...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28619236/the-effect-of-isolated-soy-protein-adjunctive-with-flaxseed-oil-on-markers-of-inflammation-oxidative-stress-acute-phase-proteins-and-wound-healing-of-burn-patients-a-randomized-clinical-trial
#9
Siavash Babajafari, Masoumeh Akhlaghi, Seyed Mohammad Mazloomi, Mehdi Ayaz, Ali Noorafshan, Peyman Jafari, Abdollah Hojhabrimanesh
INTRODUCTION: The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients. METHODS: One hundred eighty-eight patients were assessed for eligibility in this randomized controlled trial. Of these, seventy-three eligible patients (total burn surface area 20-50%) were randomly assigned to 3 isocaloric groups, labeled as control (wheat flour+corn oil (CO)), ISP+FO, and ISP+CO, to receive these nutrients for 3 weeks...
June 12, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28618058/detection-of-iron-restriction-in-anaemic-and-non-anaemic-patients-new-diagnostic-approaches
#10
Lothar Thomas, Christian Thomas
OBJECTIVE: The aim of this study was to detect iron restriction in non-anaemic patients and iron-restricted erythropoiesis (IRE) in patients with anaemia. METHOD: Haematologic indices and biochemical markers of iron deficiency (ID) were determined using the clinically accepted cut-off level for serum ferritin of ≤30 μg/l as reference of ID. To evaluate the prevalence of iron restriction and IRE in patients with higher ferritin levels we used the thresholds of the markers of ID as reference...
June 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28617785/haemochromatosis-evaluating-the-effectiveness-of-a-novel-patient-self-management-approach-to-venesection-as-blood-donation
#11
Sonam Mishra, Dalice Sim, Peter Flanagan
AIM: We set out to evaluate the effectiveness of a new model of self management of haemochromatosis, whereby patients with stable ferritin control were discharged from the New Zealand Blood Service (NZBS) therapeutic venesection clinic and educated to manage their own venesection by regular blood donation and annual serum ferritin check by their general practitioner. METHOD: Data regarding the frequency of blood donation and serum ferritin level were collected from the NZBS and Concerto records of haemochromatosis patients in the Wellington region who had been discharged back to the care of their general practitioner between January 2014 and June 2015...
June 16, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28609534/effect-of-low-dose-ferrous-sulfate-vs-iron-polysaccharide-complex-on-hemoglobin-concentration-in-young-children-with-nutritional-iron-deficiency-anemia-a-randomized-clinical-trial
#12
Jacquelyn M Powers, George R Buchanan, Leah Adix, Song Zhang, Ang Gao, Timothy L McCavit
Importance: Iron-deficiency anemia (IDA) affects millions of persons worldwide, and is associated with impaired neurodevelopment in infants and children. Ferrous sulfate is the most commonly prescribed oral iron despite iron polysaccharide complex possibly being better tolerated. Objective: To compare the effect of ferrous sulfate with iron polysaccharide complex on hemoglobin concentration in infants and children with nutritional IDA. Design, Setting, and Participants: Double-blind, superiority randomized clinical trial of infants and children aged 9 to 48 months with nutritional IDA (assessed by history and laboratory criteria) that was conducted in an outpatient hematology clinic at a US tertiary care hospital from September 2013 through November 2015; 12-week follow-up ended in January 2016...
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28601871/perinatal-factors-affecting-serum-hepcidin-levels-in-low-birth-weight-infants
#13
Kenji Ichinomiya, Kenichi Maruyama, Takahiro Inoue, Aya Koizumi, Fumitaka Inoue, Kazuyo Fukuda, Yu Yamazaki, Hirokazu Arakawa
BACKGROUND: Hepcidin, an iron-regulatory hormone, plays a key role in preventing iron overload. Few studies have investigated the regulation of hepcidin in low-birth-weight (LBW) infants who are vulnerable to iron imbalance. OBJECTIVES: To identify perinatal factors associated with serum hepcidin levels in LBW infants. METHODS: Ninety-two LBW infants with a median gestational age (GA) of 32.6 weeks and birth weight of 1,587 g were prospectively enrolled...
June 10, 2017: Neonatology
https://www.readbyqxmd.com/read/28596960/acinetobacter-baumannii-infection-in-transfusion-dependent-thalassemia-patients-with-sepsis
#14
Muzaheed Abdul Rasheed, Faisal Mousa Alzahrani, Saeed Sattar Shaikh
PURPOSE: To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS: A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth on MacConkey and blood agar culture media. A. baumannii strains were identified by microbiological methods and Gram's staining. API 20 E kit (Biomerieux, USA) was used for final identification...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28594937/hyperferritinemia-and-hypergammaglobulinemia-predict-the-treatment-response-to-standard-therapy-in-autoimmune-hepatitis
#15
Richard Taubert, Matthias Hardtke-Wolenski, Fatih Noyan, Claudine Lalanne, Danny Jonigk, Jerome Schlue, Till Krech, Ralf Lichtinghagen, Christine S Falk, Verena Schlaphoff, Heike Bantel, Luigi Muratori, Michael P Manns, Elmar Jaeckel
Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome in other chronic liver diseases and after liver transplantation. We assessed the capacity of baseline parameters including the iron status to predict the treatment response upon standard therapy in 109 patients with untreated AIH type 1 (AIH-1) in a retrospective single center study...
2017: PloS One
https://www.readbyqxmd.com/read/28592008/-analysis-of-the-influence-of-iron-overload-in-glucose-metabolism-in-thalassemia-major-patients
#16
L Y Liang, W Q Lao, Z Meng, L N Zhang, L L Hou, H Ou, Z L Liu, Z W He, X Y Luo, J P Fang
Objective: This study aimed at determining the characteristics of the glucose homeostasis and its relationship with iron overload of the patients with β-thalassemia major (β-TM). Method: From Sun Yat-sen Memorial Hospital between January 2014 and December 2015, a total of 57 transfusion-dependent β-TM patients with 5-18 years old were enrolled in this study and fasting blood glucose(FBG) and insulin level, serum ferritin (SF), serum iron, transferrin, total iron binding capacity, unsaturated iron binding capacity were determined...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28587122/anti-inflammatory-properties-of-brazilian-green-propolis-encapsulated-in-a-%C3%AE-cyclodextrin-complex-in-mice-fed-a-western-type-diet
#17
Gerald Rimbach, Alexandra Fischer, Anke Schloesser, Gerold Jerz, Naoko Ikuta, Yoshiyuki Ishida, Ryota Matsuzawa, Seiichi Matsugo, Patricia Huebbe, Keiji Terao
Ageing is often accompanied by chronic inflammation. A fat- and sugar-rich Western-type diet (WTD) may accelerate the ageing phenotype. Cell culture studies have indicated that artepillin C-containing Brazilian green propolis exhibits anti-inflammatory properties. However, little is known regarding its anti-inflammatory potential in mouse liver in vivo. In this study, female C57BL/6NRj wild-type mice were fed a WTD, a WTD supplemented with Brazilian green propolis supercritical extract (GPSE) encapsulated in γ-cyclodextrin (γCD) or a WTD plus γCD for 10 weeks...
May 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28585580/stages-of-chronic-kidney-disease-and-soluble-transferrin-receptor-stfr-ferritin-ratio
#18
Faiza Alam, Syeda Sadia Fatima, Sabeela Noor, Ahmed Bilal, Rehana Rehman
OBJECTIVE: To assess the ratio of soluble transferrin receptor to ferritin in different stages of chronic kidney disease. METHODS: This case-control study was conducted at the Aga Khan University Hospital and the Jinnah Postgraduate Medical Centre, Karachi, from January to September 2014, and comprised chronic kidney disease patients and healthy controls. Group 1 comprised controls, whereas groups 2, 3 and 4 had patients based on their mean glomerular filtration rate...
June 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28585071/impact-of-non-transferrin-bound-iron-ntbi-in-comparison-to-serum-ferritin-on-outcome-after-allogeneic-stem-cell-transplantation-asct
#19
Annekathrin Hilken, Claudia Langebrake, Christine Wolschke, Jan Felix Kersten, Holger Rohde, Peter Nielsen, Nicolaus Kröger
The optimal parameters and time points for the measurement of iron overload (IO) in allogeneic stem cell transplantation (ASCT) patients are still under discussion. Hyperferritinemia and IO are poor prognostic factors in ASCT. We hypothesize that non-transferrin-bound iron (NBTI) is possibly a better marker to predict the effect of IO on the outcome than serum ferritin (SF), which however is not specific for IO. The aim of this prospective observational trial was to evaluate the influence of NBTI in comparison to SF on the outcome of ASCT patients [overall survival, bloodstream infections (BSIs), and invasive fungal infections (IFIs)]...
June 6, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28584599/the-role-of-insulin-therapy-in-correcting-hepcidin-levels-in-patients-with-type-2-diabetes-mellitus
#20
Driton Vela, Jovica Leshoski, Elizabeta S Gjorgievska, Nikola Hadzi-Petrushev, Muharrem Jakupaj, Ramadan B Sopi, Mitko Mladenov
OBJECTIVES: Iron overload can cause or contribute to the pathogenesis of type 2 diabetes mellitus (T2DM), but how the major parameters of iron metabolism change in different settings of diabetes are still unclear. The aim of this study was to determine the relationship between iron, ferritin, and hepcidin levels in diabetic patients and the effect of insulin treatment. METHODS: The study included 80 subjects, 60 with T2DM and 20 without (control group). Serum hepcidin, insulin, ferritin, and iron levels were determined as well as other clinical parameters...
May 2017: Oman Medical Journal
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