Joseph M Rocco, Yifan Zhou, Nicholas S Liu, Elizabeth Laidlaw, Frances Galindo, Megan V Anderson, Adam Rupert, Silvia Lucena Lage, Ana M Ortega-Villa, Shiqin Yu, Andrea Lisco, Maura Manion, George S Vassiliou, Cynthia E Dunbar, Irini Sereti
People with HIV (PWH) have a higher age-adjusted mortality due to chronic immune activation and age-related comorbidities. PWH also have higher rates of clonal hematopoiesis (CH) than age-matched non-HIV cohorts, however, risk factors influencing the development and expansion of CH in PWH remain incompletely explored. We investigated the relationship between CH, immune biomarkers, and HIV-associated risk factors (CD4, CD8 T-cells, nadir CD4 count, opportunistic infections [OIs], and immune reconstitution inflammatory syndrome [IRIS]) in a diverse cohort of 197-PWH with median age of 42-years, using a 56-gene panel...
April 2, 2024: JCI Insight