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intranasal light therapy

Naomi Cook, Jennifer Miller, John Hart
Social and emotional impairment, school dysfunction, and neurobehavioral impairment are highly prevalent in survivors of childhood craniopharyngioma and negatively affect quality of life. As surgical resection of craniopharyngioma typically impairs hypothalamic/pituitary function, it has been postulated that perhaps post-operative deficiency of the hormone oxytocin may be the etiology of social/emotional impairment. Research on the benefits of oxytocin treatment as a hormone facilitating social interaction is well established...
August 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Jean Pierre Schatzmann Peron, Auriléia Aparecida de Brito, Mayra Pelatti, Wesley Nogueira Brandão, Luana Beatriz Vitoretti, Flávia Regina Greiffo, Elaine Cristina da Silveira, Manuel Carneiro Oliveira-Junior, Mariangela Maluf, Lucila Evangelista, Silvio Halpern, Marcelo Gil Nisenbaum, Paulo Perin, Carlos Eduardo Czeresnia, Niels Olsen Saraiva Câmara, Flávio Aimbire, Rodolfo de Paula Vieira, Mayana Zatz, Ana Paula Ligeiro de Oliveira
Cigarette smoke-induced chronic obstructive pulmonary disease is a very debilitating disease, with a very high prevalence worldwide, which results in a expressive economic and social burden. Therefore, new therapeutic approaches to treat these patients are of unquestionable relevance. The use of mesenchymal stromal cells (MSCs) is an innovative and yet accessible approach for pulmonary acute and chronic diseases, mainly due to its important immunoregulatory, anti-fibrogenic, anti-apoptotic and pro-angiogenic...
2015: PloS One
Matthew J Haney, Natalia L Klyachko, Yuling Zhao, Richa Gupta, Evgeniya G Plotnikova, Zhijian He, Tejash Patel, Aleksandr Piroyan, Marina Sokolsky, Alexander V Kabanov, Elena V Batrakova
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes. We posit that exosomes secreted by monocytes and macrophages can provide an unprecedented opportunity to avoid entrapment in mononuclear phagocytes (as a part of the host immune system), and at the same time enhance delivery of incorporated drugs to target cells ultimately increasing drug therapeutic efficacy...
June 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
Nicolas Dufour, Laurent Debarbieux, Mélanie Fromentin, Jean-Damien Ricard
OBJECTIVE: To study the effect of bacteriophage treatment on highly virulent extraintestinal Escherichia coli pneumonia in mice and compare it with conventional antimicrobial treatment. DESIGN: Animal investigation. SETTING: University research laboratory. SUBJECTS: Pathogen-free 8-week-old Balb/cJRj male mice. INTERVENTIONS: Two bacteriophages (536_P1 and 536_P7) were isolated from sewage using strain 536, a highly virulent extraintestinal E...
June 2015: Critical Care Medicine
Mehmet Ozgür Avincsal, Seda Ozbal, Ahmet Omer Ikiz, Cetin Pekcetin, Enis Alpin Güneri
OBJECTIVES: Allergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation area by passing through the interstitium and capillary walls. To pass through these barriers, the inflammatory cells degrade extracellular matrix proteins. Matrix metalloproteinases (MMPs) released by inflammatory cells mediate the degradation of these proteins...
June 2014: Clinical and Experimental Otorhinolaryngology
Xian Wang, Lei Zhang, Wei Duan, Bin Liu, Ping Gong, Yusong Ding, Xiongwen Wu
Triptolide is one of the main active components in the Chinese herb Tripterygium wilfordii Hook F, which has been demonstrated to possess anti‑inflammatory properties. The aim of this study was to investigate the effects of triptolide on lipopolysaccharide (LPS)‑induced acute lung injury (ALI) in mice and to explore the possible mechanisms. Mice were administered LPS intranasally to induce lung injury, and triptolide was administered intraperitoneally 1 h prior to the LPS challenge. Triptolide‑treated mice exhibited significantly reduced levels of leukocytes, myeloperoxidase activity and edema of the lung, as well as tumour necrosis factor‑α, interleukin (IL)‑1β and IL‑6 production in the bronchoalveolar lavage fluid compared with LPS‑treated mice...
July 2014: Molecular Medicine Reports
Erkan Vuralkan, Hatice Bengu Cobanoglu, Abdullah Arslan, Selcuk Arslan, Sevdegul Mungan, Selcuk Tatar, Akın Savas Toklu
We aimed to evaluate nasal mucosal changes and efficiency of nasal steroids and diclofenac on nasal mucosa during hyperbaric oxygen (HBO) treatment. Forty adult Albino-Wistar rats were randomized into four groups. Group 1 (control group) (n = 10) not exposed to hyperbaric or enhanced oxygen concentrations; group 2 (HBO group) (n = 10) underwent only HBO treatment; group 3 (n = 10) received HBO and intranasal mometasone furoate (10 μl/day); group 4 (n = 10) treated with HBO and diclofenac sodium (10 mg/kg/day ip)...
August 2014: European Archives of Oto-rhino-laryngology
Flávia Chiva Carvalho, Michel Leandro Campos, Rosângela Gonçalves Peccinini, Maria Palmira Daflon Gremião
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid crystal phase, taking advantage of its lyotropic phase behavior. Flow rheology measurements showed that the formulation composed of PPG-5-CETETH-20, oleic acid and water (55, 30, 15% w/w), denominated P, has Newtonian flow behavior. Polarized light microscopy (PLM) revealed that formulation P is isotropic, whereas its 1:1 (w/w) dilution with artificial nasal mucus (ANM) changed the system to an anisotropic lamellar phase (PD)...
May 2013: European Journal of Pharmaceutics and Biopharmaceutics
István Balázs Németh, Ottó Zsíros, Andrea Koreck, Zsolt Bella, Ágnes Kiricsi, Ferenc Ignácz, Edit Kadocsa, Lajos Kemény
Intranasal phototherapy has been found to be effective for the treatment of nasal polyposis (NP) therefore the aim was to investigate the apoptosis inducing effect of phototherapy in NP. In this ex vivo study nasal polyp tissue was surgically collected from 21 consecutive patients with chronic rhinosinusitis (CRS) associated with NP. The removed polyps were cut into pieces and tissue samples were irradiated in vitro by different doses of combined ultraviolet and visible light (UV/VIS: 280-650 nm) and by selective ultraviolet and visible light (sUV/VIS: 295-650 nm)...
December 5, 2012: Journal of Photochemistry and Photobiology. B, Biology
S C Leong
Photodynamic therapy has been used in treating immune-mediated dermatological conditions such as psoriasis and atopic dermatitis. There are emerging reports on the efficacy of intranasal phototherapy in allergic rhinitis. The aim of this review was to assess intranasal phototherapy in the treatment of allergic rhinitis, with particular emphasis on clinical efficacy, scientific basis and safety. A structured search of the U.S. National Library of Medicine (PubMed), the Cochrane Collaboration library, Google Scholar and ISI Web of Knowledge database was undertaken using MeSH terms `phototherapy` and `rhinitis...
December 2011: Rhinology
Tayfun Apuhan, Elçin Hakan Terzi, Aysel Kükner, Uzeyir Gök
Allergic rhinitis is a high-incidence allergic inflammation of the nasal airways that impacts quality of life. Of the numerous therapies used to treat allergic rhinitis, intranasal phototherapy has emerged as a promising new treatment modality for inflammatory airway disease. Phototherapy is widely used for the treatment of immune-mediated skin diseases because its profound immunosuppressive effect inhibits hypersensitivity reactions in the skin. Intranasal phototherapy using a combination of Ultraviolet-A (UVA) and Ultraviolet-B (UVB) plus Visible light (VIS) has been shown to suppress the clinical symptoms of allergic rhinitis, but limited data regarding its adverse effects on the nasal mucosa currently exists...
October 5, 2011: Journal of Photochemistry and Photobiology. B, Biology
Andrea Koreck, Zsolt Bella, Edit Kadocsa, Adam Perenyi, Laszlo Tiszlavicz, Istvan Nemeth, Maria Kiss, Tudor Rares Olariu, Jozsef Jori, Lajos Kemeny
Nasal polyposis (NP) affects 4% of the general population, representing a major health problem. In spite of complex (surgical and medical) treatment, the relapse rate is high and it has a negative impact on the quality of life. Recently we found that intranasal photochemotherapy with ultraviolet A light (PUVA) is effective in allergic rhinitis. In the present study PUVA was administered for 6 weeks in 7 patients with NP. Nasal lavages were performed in all patients before and at the end of the treatment; from four patients a biopsy specimen was also collected...
January 2010: Roumanian Archives of Microbiology and Immunology
Gunamini Dahanayake, Ashok Rokade, Swapna Ghosh, Vivek Raut
A 56-year-old Caucasian man was referred to our clinic with the complaint of right sided unilateral nasal blockage which had been present for one year. Anterior rhinoscopy and computed tomograpy scan revealed a mass, filling the right nostril completely and lying in the right inferior meatus inseparable from the inferior turbinate. Following the biopsy, histopathological examination and immunohistochemical analyses, the diagnosis of Mantle cell lymphoma was established. To our knowledge, there have been no previous reports of a Mantle cell lymphoma presenting as an intranasal mass in the literature...
January 2010: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
P Vera-Cruz, M Ferreira, C Zagalo, Martins J dos Santos, A P Aguas
OBJECTIVE: We used light microscopy to search for local changes of the nasal mucosa associated with daily intranasal administration of mometasone furoate (MF), azelastine (AZ) or salmon calcitonin (SC). STUDY DESIGN: Biopsies of the lower nasal turbinate were obtained from four groups of 8 individuals after 14 days of daily administration of a saline solution (control group) or of MF AZ and SC. METHODS: Small biopsies of the anterior portion of the lower nasal turbinate were collected with the help of a Hartmann forceps under direct visual inspection...
2009: Revue de Laryngologie—Otologie—Rhinologie
Ayelet Zauberman, Avital Tidhar, Yinon Levy, Erez Bar-Haim, Gideon Halperin, Yehuda Flashner, Sara Cohen, Avigdor Shafferman, Emanuelle Mamroud
An important virulence strategy evolved by bacterial pathogens to overcome host defenses is the modulation of host cell death. Previous observations have indicated that Yersinia pestis, the causative agent of plague disease, exhibits restricted capacity to induce cell death in macrophages due to ineffective translocation of the type III secretion effector YopJ, as opposed to the readily translocated YopP, the YopJ homologue of the enteropathogen Yersinia enterocolitica Oratio8. This led us to suggest that reduced cytotoxic potency may allow pathogen propagation within a shielded niche, leading to increased virulence...
2009: PloS One
Carolina Sofer-Podesta, John Ang, Neil R Hackett, Svetlana Senina, David Perlin, Ronald G Crystal, Julie L Boyer
Pneumonic plague, caused by inhalation of Yersinia pestis, represents a major bioterrorism threat for which no vaccine is available. Based on the knowledge that genetic delivery of monoclonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antibody expression, we evaluated the hypothesis that Ad-mediated delivery of a neutralizing antibody directed against the Y. pestis V antigen would protect mice against a Y. pestis challenge. MAbs specific for the Y. pestis V antigen were generated, and the most effective in protecting mice against a lethal intranasal Y...
April 2009: Infection and Immunity
Davor Skaricic, Chani Traube, Bishnu De, Ju Joh, Julie Boyer, Ronald G Crystal, Stefan Worgall
Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract infections. Protection against infection with RSV can be achieved by monthly administration of the humanized monoclonal antibody palivizumab. The present study analyzes if genetic delivery of a murine version of palivizumab by single administration would achieve high-level and sustained antibody expression to protect mice against pulmonary infection with RSV. A murine version of the palivizumab antibody was constructed by replacing the human sequences with sequences from the constant region of a murine IgG1 antibody, while preserving the complementarity-determining region...
August 15, 2008: Virology
A Koreck, A Szechenyi, M Morocz, A Cimpean, Zs Bella, E Garaczi, M Raica, T R Olariu, I Rasko, L Kemeny
RATIONALE: Rhinophototherapy has been shown to be effective in the treatment of allergic rhinitis. Considering that phototherapy with ultraviolet light (UV) induces DNA damage, it is of outstanding importance to evaluate the damage and repair process in human nasal mucosa. METHODS: We have investigated eight patients undergoing intranasal phototherapy using a modified Comet assay technique and by staining nasal cytology samples for cyclobutane pyrimidine dimers (CPDs), which are UV specific photoproducts...
December 14, 2007: Journal of Photochemistry and Photobiology. B, Biology
Lajos Kemény, Andrea Koreck
Phototherapy has a profound immunosuppressive effect and is widely used for the treatment of immune mediated skin diseases. Phototherapy is able to inhibit immediate type hypersensitivity reaction in the skin. Intranasal phototherapy is a new approach for treatment of allergic rhinitis. In two open studies, 308 nm excimer laser and topical PUVA therapy efficiently inhibited clinical symptoms of allergic rhinitis. In a randomized, double-blind study combined low dose UVB, low dose UVA and visible light proved to be effective in reducing symptom scores for sneezing, rhinorrhea, nasal itching and the total nasal score in ragweed allergic patients...
April 2, 2007: Journal of Photochemistry and Photobiology. B, Biology
Geng Xu, Hong-yan Jiang, Rui Xu, Jian-bo Shi, Wei-ping Wen
OBJECTIVE: This study was aimed to explore the necessity of nasal endoscopic operation for bilateral traumatic optic neuropathy. METHODS: Four patients with complete blind resulted from traumatic impairment of bilateral optic nerves were selected to receive a combined treatment of nasal endoscopic optic nerve decompression (NEOND) with all-around medication. RESULTS: The vision of all patients was improved except one who lost vision immediately after trauma...
June 2006: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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