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https://www.readbyqxmd.com/read/29332950/microwave-evaluation-of-electromigration-susceptibility-in-advanced-interconnects
#1
Christopher E Sunday, Dmitry Veksler, Kin C Cheung, Yaw S Obeng
Traditional metrology has been unable to adequately address the needs of the emerging integrated circuits (ICs) at the nano scale; thus, new metrology and techniques are needed. For example, the reliability challenges in fabrication need to be well understood and controlled to facilitate mass production of through-substrate-via (TSV) enabled three-dimensional integrated circuits (3D-ICs). This requires new approaches to the metrology. In this paper, we use the microwave propagation characteristics to study the reliability issues that precede the physical damage caused by electromigration in the Cu-filled TSVs...
November 7, 2017: Journal of Applied Physics
https://www.readbyqxmd.com/read/29330082/clinical-trials-recruitment-planning-a-proposed-framework-from-the-clinical-trials-transformation-initiative
#2
Grant D Huang, Jonca Bull, Beth Harper, Elizabeth Mahon, Kelly McKee, Jamie N Roberts
Patient recruitment is widely recognized as a key determinant of success for clinical trials. Yet a substantial number of trials fail to reach recruitment goals-a situation that has important scientific, financial, ethical, and policy implications. Further, there are important effects on stakeholders who directly contribute to the trial including investigators, sponsors, and study participants. Despite efforts over multiple decades to identify and address barriers, recruitment challenges persist. To advance a more comprehensive approach to trial recruitment, the Clinical Trials Transformation Initiative (CTTI) convened a project team to examine the challenges and to issue actionable, evidence-based recommendations for improving recruitment planning that extend beyond common study-specific strategies...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29329960/the-future-of-lgbt-cancer-care-practice-and-research-implications
#3
REVIEW
David Rice, Matthew B Schabath
OBJECTIVES: To synthesize state of the knowledge collected in this volume and propose future directions for lesbian, gay, bisexual and transgender (LGBT) cancer practice, education, research, and advocacy. DATA SOURCES: Current and extant literature. CONCLUSION: Health care disparities that are known but not yet fully elucidated in the LGBT population carry into the cancer arena. Substantially more effort is required in the domains of patient care, nursing practice, nursing and patient-facing services provider education, patient education, nursing and interprofessional research, governmental commitment, professional organization action, and patient advocacy...
January 9, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29329573/female-genital-mutilation-cutting-in-italy-an%C3%A2-enhanced-estimation-for-first-generation-migrant-women-based-on-2016-survey-data
#4
Livia Elisa Ortensi, Patrizia Farina, Els Leye
BACKGROUND: Migration flows of women from Female Genital Mutilation/Cutting practicing countries have generated a need for data on women potentially affected by Female Genital Mutilation/Cutting. This paper presents enhanced estimates for foreign-born women and asylum seekers in Italy in 2016, with the aim of supporting resource planning and policy making, and advancing the methodological debate on estimation methods. METHODS: The estimates build on the most recent methodological development in Female Genital Mutilation/Cutting direct and indirect estimation for Female Genital Mutilation/Cutting non-practicing countries...
January 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29328876/meta-analysis-of-complex-interventions
#5
Emily E Tanner-Smith, Sean Grant
Meta-analysis is a prominent method for estimating the effects of public health interventions, yet these interventions are often complex in ways that pose challenges to using conventional meta-analytic methods. This article discusses meta-analytic techniques that can be used in research syntheses on the effects of complex public health interventions. We first introduce the use of complexity frameworks to conceptualize public health interventions. We then present a menu of meta-analytic procedures for addressing various sources of complexity when answering questions about the effects of public health interventions in research syntheses...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29328532/population-genomic-footprints-of-host-adaptation-introgression-and-recombination-in-coffee-leaf-rust
#6
Diogo Nuno Silva, Vítor Várzea, Octávio Salgueiro Paulo, Dora Batista
Coffee Leaf Rust, caused by Hemileia vastatrix (Hv), represents the biggest threat to coffee production worldwide and ranks amongst the most serious fungal diseases in history. Despite a recent series of outbreaks and emergence of hyper-virulent strains, the population evolutionary history and potential of this pathogen remains poorly understood. To address this issue, we used RADseq to generate ∼19,000 SNPs across a worldwide collection of 37 Hv samples. Contrarily to the longstanding idea that Hv represents a genetically unstructured and cosmopolitan species, our results reveal the existence of a cryptic species complex with marked host tropism...
January 12, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29327813/computational-tools-for-the-identification-and-interpretation-of-sequence-motifs-in-immunopeptidomes
#7
REVIEW
Bruno Alvarez, Carolina Barra, Morten Nielsen, Massimo Andreatta
Recent advances in proteomics and mass-spectrometry have widely expanded the detectable peptide repertoire presented by major histocompatibility complex (MHC) molecules on the cell surface, collectively known as the immunopeptidome. Finely characterizing the immunopeptidome brings about important basic insights into the mechanisms of antigen presentation, but can also reveal promising targets for vaccine development and cancer immunotherapy. In this report, we describe a number of practical and efficient approaches to analyze immunopeptidomics data, discussing the identification of meaningful sequence motifs in various scenarios and considering current limitations...
January 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29326426/mrna-vaccines-a-new-era-in-vaccinology
#8
REVIEW
Norbert Pardi, Michael J Hogan, Frederick W Porter, Drew Weissman
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans...
January 12, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29325395/controversial-issues-in-radiotherapy-for-rectal-cancer-a-systematic-review
#9
REVIEW
Jong Hoon Kim
The role of radiotherapy (RT) as an adjuvant to surgical options in the treatment of locally advanced rectal cancer has been established as it reduces local recurrence when combined with surgical resection and enhances survival when used in multidisciplinary treatment. However, many issues need to be addressed; some of these can render RT unnecessary, whereas others can reveal a new role of RT in rectal cancer. This review will discuss not only the basic role of RT but also the associated but controversial issues in detail in an attempt to find answers and determine future directions for the next decade...
December 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29320792/-advanced-care-planning-and-its-relevance-for-emergency-and-intensive-care-medicine
#10
Friedemann Nauck, Georg Marckmann, Jürgen In der Schmitten
Like in other countries, advance care planning (ACP) is currently being implemented in Germany as a new concept to realise valid and effective advance directives. This concept comprises processes to explore and document individual preferences for future treatment, and to honour them at a time when the person is incapacitated. ACP aims to ensure that patients will be treated according to their preferences when they are no longer capable due to acute health crises or chronic diseases. This paper gives an overview of the concept of ACP with a focus on relevant issues for emergency and intensive care medicine...
January 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29316202/anticoagulant-prophylaxis-and-therapy-in-children-current-challenges-and-emerging-issues
#11
Fiona Newall, Brian Branchford, Christoph Male
This review aims to describe the unique challenges of anticoagulant prophylaxis and treatment in children, and to highlight areas for research for improving clinical outcomes of children with thromboembolic disease. The evidence presented demonstrates the challenges of advancing the evidence-base informing optimal management of thromboembolic disease in children. Recent observational studies have identified risk factors of venous thromboembolism in children, but there are few interventional studies assessing the benefit-risk of using thromboprophylaxis in risk-stratified clinical subgroups...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29310672/3d-vena-contracta-area-after-mitraclip%C3%A2-procedure-precise-quantification-of-residual-mitral-regurgitation-and-identification-of-prognostic-information
#12
Alexander Dietl, Christine Prieschenk, Franziska Eckert, Christoph Birner, Andreas Luchner, Lars S Maier, Stefan Buchner
BACKGROUND: Percutaneous mitral valve repair (PMVR) is increasingly performed in patients with severe mitral regurgitation (MR). Post-procedural MR grading is challenging and an unsettled issue. We hypothesised that the direct planimetry of vena contracta area (VCA) by 3D-transoesophageal echocardiography allows quantifying post-procedural MR and implies further prognostic relevance missed by the usual ordinal scale (grade I-IV). METHODS: Based on a single-centre PMVR registry containing 102 patients, the association of VCA reduction and patients' functional capacity measured as six-minute walk distance (6 MW) was evaluated...
January 9, 2018: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29304996/-what-did-maxwell-s-equations-really-have-to-do-with-edison-s-invention-addressing-the-complexity-of-developing-clinical-interventions-for-skeletal-muscle-disease
#13
Jonathan Dando
To reach the healthcare market and have a medical intervention reimbursed in any format carries high risk and very low success rates. Even when all regulatory hurdles have been surpassed, there is no guarantee that the product will be purchased; a different body makes that decision using criteria typically unknown to early-stage innovators and intervention developers. In the context of skeletal muscle diseases, the field is at a crossroads; accurate diagnoses are difficult to obtain, patient management and monitoring are equally difficult, cures are evasive, and disease progression is not well enough understood in the human to identify clear targets (irrespective of whether the specific muscle disease is rare or frequent because the progression is slow and the tissue large)...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29304561/crosstalk-between-cellular-redox-state-and-the-anti-apoptotic-protein-bcl-2
#14
Sebastian Other-Gee Pohl, Mark Agostino, Arun Dharmarajan, Shazib Pervaiz
SIGNIFICANCE B cell lymphoma-2 (Bcl-2) is the prototypical anti-apoptotic member of the Bcl-2 family that comprises proteins with contrasting effects on cell fate. Identified as a consequence chromosomal translocation (t 14:18) in human lymphoma, subsequent studies have revealed mutations and/or copy number alterations, as well as post-translational modifications, of Bcl-2 in a variety of cancers. The canonical function of Bcl-2 is linked to its ability to inhibit mitochondrial membrane permeabilization, regulating apoptosome assembly and activation by blocking cytosolic translocation of death amplification factors...
January 5, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29304554/-i-in-vivo-i-epr-radical-concepts-for-translation-to-the-clinical-setting
#15
Valery V Khramtsov
EPR-based spectroscopic and imaging techniques allow for the study of free radicals - molecules with one or more unpaired electrons. Biological EPR applications include detection of endogenous biologically-relevant free radicals as well as use of specially designed exogenous radicals to probe local microenvironments. This forum issue focuses on recent advances in the field of <i>in vivo</i> EPR applications discussed at the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017)...
January 5, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29302602/what-are-the-ethical-questions-raised-by-the-integration-of-intensive-care-into-advance-care-planning
#16
REVIEW
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
A major goal of intensive care units (ICUs) is to offer optimal management, but for many patients admitted to the ICU, they are unlikely to yield any lasting benefit. In this context, the ICU physician remains a key intermediary, particularly when a decision regarding possible limitation or withdrawal of life-sustaining therapy becomes necessary. The possibility of admission to the ICU, and the type of care the patient would like to receive there, should be integrated into the healthcare project in agreement with the patient, regardless of the stage of disease that the patient suffers from...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29302599/what-are-the-ethical-aspects-surrounding-the-collegial-decisional-process-in-limiting-and-withdrawing-treatment-in-intensive-care
#17
REVIEW
Jean-Pierre Quenot, Fiona Ecarnot, Nicolas Meunier-Beillard, Auguste Dargent, Audrey Large, Pascal Andreu, Jean-Philippe Rigaud
The decision to limit or withdraw life-support treatment is an integral part of the job of a physician working in the intensive care unit, and of the approach to care. However, this decision is influenced by a number of factors. It is widely accepted that a medical decision that will ultimate lead to end-of-life in the intensive care unit (ICU) must be shared between all those involved in the care process, and should give precedence to the patient's wishes (either directly expressed by the patient or in written form, such as advance directives), and taking into account the opinion of the patient's family, including the surrogate if the patient is no longer capable of expressing themselves...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29295624/nad-deficiency-is-a-common-central-pathological-factor-of-a-number-of-diseases-and-aging-mechanisms-and-therapeutic-implications
#18
Mingchao Zhang, Weihai Ying
Increasing evidence has indicated critical roles of NAD+ in various biological functions. NAD+ deficiency has been found in models of a number of diseases such as cerebral ischemia, myocardial ischemia and diabetes, and in models of aging. Application of NAD+ or other approaches that can restore NAD+ levels are highly protective in these models of diseases and aging. NAD+ produces its beneficial effects by targeting at multiple pathological pathways, including attenuating mitochondrial alterations, DNA damage and oxidative stress by modulating such enzymes as sirtuins, glyceraldehyde-3-phosphate dehydrogenase and AP endonuclease...
January 2, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29289241/strategies-and-tactics-for-the-synthesis-of-complex-alkaloids
#19
Scott A Snyder
Efforts to achieve the laboratory synthesis of complex natural products have long served as a means to advance the science of organic chemistry. Indeed, core physical organic principles, new reagents and synthetic transformations, effective strategies for stereocontrolled synthesis, and useful pharmaceutical agents are but a few advances that have issued from such endeavors over the course of the past century. Within this review are recounted selected research programs from the author's laboratory seeking to add to that repertoire of discoveries by targeting complex polycyclic alkaloids for synthesis...
December 1, 2017: Chimia
https://www.readbyqxmd.com/read/29285899/design-of-polymeric-culture-substrates-to-promote-proangiogenic-potential-of-stem-cells
#20
REVIEW
Byeong-Ju Kwon, Xintong Wang, Mi-Lan Kang, Jin You, Shin-Jeong Lee, Won Shik Kim, Young-Sup Yoon, Jong-Chul Park, Hak-Joon Sung
Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities...
December 29, 2017: Macromolecular Bioscience
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