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Platelet lymphocyte

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https://www.readbyqxmd.com/read/28213742/comparison-of-systemic-inflammatory-and-nutritional-scores-in-colorectal-cancer-patients-who-underwent-potentially-curative-resection
#1
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection. METHOD: We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival...
February 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28212553/the-clinical-use-of-the-platelet-lymphocyte-ratio-and-lymphocyte-monocyte-ratio-as-prognostic-predictors-in-colorectal-cancer-a-meta-analysis
#2
Ya-Huan Guo, Hai-Feng Sun, Yan-Bing Zhang, Zi-Jun Liao, Lei Zhao, Jie Cui, Tao Wu, Jian-Rong Lu, Ke-Jun Nan, Shu-Hong Wang
BACKGROUND: Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis. METHODS: Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28210087/prognostic-significance-of-the-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-patients-with-stage-iii-and-iv-colorectal-cancer
#3
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
AIM: To evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC). METHODS: Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28206965/prognostic-role-of-platelet-to-lymphocyte-ratio-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#4
Yongzhao Zhao, Guangyan Si, Fengshang Zhu, Jialiang Hui, Shangli Cai, Chenshen Huang, Sijin Cheng, Abdel Hamid Fathy, Yi Xiang, Jing Li
BACKGROUND AND AIMS: Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC. RESULTS: A total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203340/the-relationship-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-with-gastrointestinal-bleeding-in-henoch-schonlein-purpura
#5
Ozlem Bostan Gayret, Meltem Erol, Hikmet Tekin Nacaroglu
OBJECTIVES: Henoch-Schonlein Purpura (HSP) is the most widespread systemic vasculitis during childhood. Gastrointestinal tract retention and gastrointestinal bleeding are among its major complications. Neutrophil-Lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are indicators related to inflammatory diseases. This study evaluated the relationship between NLR or PLR and gastrointestinal bleeding in HSP. METHODS: The study consisted of 119 patients and 40 healthy children in the same age group...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28194063/initial-lymphocyte-count-as-prognostic-indicator-for-childhood-immune-thrombocytopenia
#6
Sinan Akbayram, Kamuran Karaman, Murat Dogan, Lokman Ustyol, Mesut Garipardic, Ahmet Faik Oner
Acute ITP is a benign, self-limiting disease. Chronic ITP is diagnosed when thrombocytopenia persists beyond 12 months. The main objective of the present study was to examine whether absolute lymphocyte counts at diagnosis has predictive value with chronic ITP. A total of 601 patients diagnosed as ITP between 1995 and 2014 were retrospectively evaluated. CBCs with differential counts were performed at presentation for 601 patients. Absolute lymphocyte counts at presentation were independently predictive of disease duration...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28191768/multimodal-delivery-of-isogenic-mesenchymal-stem-cells-yields-synergistic-protection-from-retinal-degeneration-and-vision-loss
#7
Benjamin Bakondi, Sergey Girman, Bin Lu, Shaomei Wang
We previously demonstrated that subretinal injection (SRI) of isogenic mesenchymal stem cells (MSCs) reduced the severity of retinal degeneration in Royal College of Surgeons rats in a focal manner. In contrast, intravenous MSC infusion (MSC(IV) ) produced panoptic retinal rescue. By combining these treatments, we now show that MSC(IV) supplementation potentiates the MSC(SRI) -mediated rescue of photoreceptors and visual function. Electrophysiological recording from superior colliculi revealed 3.9-fold lower luminance threshold responses (LTRs) and 22% larger functional rescue area from combined treatment compared with MSC(SRI) alone...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28182347/the-diagnostic-value-of-procalcitonin-versus-other-biomarkers-in-prediction-of-bloodstream-infection
#8
Ya-Ping Pan, Ya-Ping Fang, Yuan-Hong Xu, Zhong-Xin Wang, Ji-Lu Shen
BACKGROUND: We compared the diagnostic utility of procalcitonin (PCT), C-reactive protein (CRP), and hematological markers, including white blood cell count (WBC), neutrophils (NEU), percentage of neutrophils (NEU%), lymphocytes (LYM), neutrophil-lymphocyte count ratio (NLCR), and platelet count (PLT) for predicting bloodstream infection (BSI), which was confirmed by blood culture (BC). METHODS: A retrospective analysis was conducted for 1807 inpatients. The level of PCT, CRP, blood cells, and blood culture results were compared between the positive blood culture group and negative blood culture group; each indicator was analyzed in the performance of bacterial BSI diagnosis by drawing ROC curves...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28178164/blood-mean-platelet-volume-and-platelet-lymphocyte-ratio-as-new-predictors-of-hip-osteoarthritis-severity
#9
Özlem Taşoğlu, Ali Şahin, Gülşah Karataş, Engin Koyuncu, İrfan Taşoğlu, Osman Tecimel, Neşe Özgirgin
Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to evaluate the levels of blood PLR and MPV in radiographic hip OA. A total of 880 patients were evaluated retrospectively and after certain exclusion criteria, 237 of them who have primary hip OA were included...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177528/correlation-of-platelet-to-lymphocyte-ratio-plr-and-neutrophil-to-lymphocyte-ratio-nlr-with-timi-frame-count-in-stemi
#10
Hossein Vakili, Mahin Shirazi, Mahsa Charkhkar, Isa Khaheshi, Mehdi Memaryan, Mohammadreza Naderian
BACKGROUND: Impaired coronary artery reflow after primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated with post-intervention adverse effects. Thus finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, Platelet-to -Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) have been introduced. In the present study, we aimed to investigate correlation of PLR and NLR with Thrombolysis In Myocardial Infarction (TIMI) frame count...
February 8, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28169460/alterations-of-the-hematologic-cells-in-synthetic-cannabinoid-users
#11
Derya Guzel, Ahmet Bulent Yazici, Esra Yazici, Atila Erol
BACKGROUND: Functions, morphology, distributions, and index of the circulating cells are the most useful parameters that indicate various inflammatory and toxic conditions. The aim of this study was to investigate the clinical significance of these parameters in patients diagnosed with (synthetic) cannabis use disorder. METHODS: This study included a total of 40 patients in the study group (SG) with synthetic cannabis use; and 40 healthy individuals as the control group (CG)...
February 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28168367/clinical-implications-of-nonspecific-pulmonary-nodules-identified-during-the-initial-evaluation-of-patients-with-head-and-neck-squamous-cell-carcinoma
#12
Minsu Kwon, Sang Hoon Lee, Yoon Se Lee, Choong Wook Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVE: We aimed to identify the clinical implications of nonspecific pulmonary nodules (NPNs) detected in the initial staging workup for patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Medical records of patients who had been diagnosed and treated in our hospital were retrospectively analysed. After definite treatment, changes of NPNs detected on initial evaluation were monitored via serial chest computed tomography. The associations between NPNs and the clinicopathological characteristics of primary HNSCC were evaluated...
February 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28164677/prognostic-value-of-pre-operative-platelet-to-lymphocyte-ratio-in-patients-with-resected-primary-hepatocellular-carcinoma
#13
Lihong Dong, Kai Bai, Yi Cao, Qiaojia Huang, Lizhi Lv, Yi Jiang
BACKGROUND: The platelet to lymphocyte ratio (PLR) is a readily available cancer biomarker but its prognostic value for patients with resected primary hepatocellular carcinoma (HCC) is uncertain. Thus, we investigated the relationship between PLR and survival of patients with resected primary HCC in the Fujian area, a high occurrence area of HCC in China. METHODS: This retrospective study included 337 patients with primary HCC who underwent surgical removal of primary liver cancer between 2004 and 2012 in Fuzhou General Hospital in Fujian, China...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164629/a-controversial-new-approach-to-address-hematological-parameters-in-hashimoto-s-thyroiditis
#14
Dilek Arpaci, Gonul Gurol, Hasan Ergenc, Hayrullah Yazar, Aysel G Tocoglu, Ihsan H Ciftci, Ali Tamer
BACKGROUND: Hashimoto's thyroiditis (HT) is a common autoimmune disorder. Genetic, environmental, and immunological factors all play a role in the pathogenesis of HT, but the effects of lymphocytes and platelets on the pathophysiology of HT are still unknown. In this study, we evaluated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in HT groups and HT subgroups with low cardiovascular risks. METHODS: This study included 92 patients with HT and 38 control subjects...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164624/elevated-preoperative-platelet-to-lymphocyte-ratio-indicates-poor-survival-in-patients-with-resected-high-grade-serous-ovarian-carcinoma
#15
Dan Hu, Youdong Lin, Fangfang Liu, Li Zeng, Xiaojuan Ouyang, Kai Wang, Xiongwei Zheng, Qiaojia Huang
BACKGROUND: Platelet to lymphocyte ratio (PLR) is widely used as an inflammation-related cancer biomarker. However, since its prognostic importance in resected high-grade serous ovarian carcinoma (HGSC) is still unknown, we investigated the association between PLR and the prognosis in resected HGSC in this study. METHODS: Details of 103 patients with HGSC who underwent ovarian resection were collected in this retrospective study. Preoperative PLR was calculated based on platelet and lymphocyte count values...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160526/association-between-platelet-to-lymphocyte-ratio-plateletcrit-and-the-presence-and-severity-of-hyperemesis-gravidarum
#16
Cift Tayfur, Dincgez Cakmak Burcu, Ozgen Gulten, Dundar Betul, Guclu Tugberk, Ozdenoglu Onur, Korkmazer Engin, Ozdemir Orcun
AIM: Hyperemesis gravidarum (HG) can be defined as intractable nausea and vomiting leading to electrolyte imbalance, ketonuria, nutrition deficiency and weight loss. Inflammation is known to play a crucial role in HG and many inflammatory markers have been studied to achieve early diagnosis. We investigated the association of the platelet to lymphocyte ratio and plateletcrit with the presence and severity of HG. METHODS: We retrospectively enrolled 433 pregnant women with a diagnosis of HG and 160 gestational age matched healthy pregnant women, who were admitted to a large tertiary research and training hospital between January and December 2015...
February 4, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28154994/neutrophil-to-lymphocyte-ratio-predicts-outcome-in-limited-disease-small-cell-lung-cancer
#17
Lukas Käsmann, Louisa Bolm, Steven E Schild, Stefan Janssen, Dirk Rades
INTRODUCTION: Patients with limited disease small-cell lung cancer (SCLC) receive radiochemotherapy followed by prophylactic cranial irradiation. The prognosis of these patients remains poor with a median survival of 16-24 months. Systemic inflammation was suggested as an important prognostic factor for outcomes. This study investigated the impact of systemic inflammation measured with neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at first diagnosis in patients with limited disease SCLC for outcomes...
February 2, 2017: Lung
https://www.readbyqxmd.com/read/28153603/high-programmed-death-1-expression-on-t-cells-in-aplastic-anemia
#18
Wanhong Zhao, Yilin Zhang, Pengyu Zhang, Juan Yang, Longjin Zhang, Aili He, Wanggang Zhang, Tamura Hideto
Programmed death 1 (PD-1) has been reported to be associated with aberrant regulation of T cells activation in aplastic anemia (AA). However, the connection between PD-1 expression status and AA needs to be further explored. The aim of this study is to investigate PD-1 expression status on T cells in AA patients and to explore the effect of PD-1 on apoptosis of T cells and BMHSCs. The concentration of platelet, lymphocyte and hemoglobin in peripheral blood of AA patients and healthy volunteers was detected by automatic blood-counter system...
January 30, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28151879/relation-between-tumor-fdg-uptake-and-hematologic-prognostic-indicators-in-stage-i-lung-cancer-patients-following-curative-resection
#19
Eugene Jeong, Seung Hyup Hyun, Seung Hwan Moon, Young Seok Cho, Byung-Tae Kim, Kyung-Han Lee
Hematologic parameters of systemic inflammation are receiving attention as promising prognostic indicators in cancer patients. Here, we investigated the relation and compared the prognostic values of circulating blood cell-based parameters and tumor F-fluoro-2-deoxyglucose (FDG) uptake in patients with stage I nonsmall cell lung cancers (NSCLC).Subjects were 1034 patients with newly diagnosed stage I NSCLC who underwent FDG positron emission tomography/computed tomography (PET/CT) followed by curative resection...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28149656/immune-and-inflammatory-gene-expressions-are-different-in-beh%C3%A3-et-s-disease-compared-to-those-in-familial-mediterranean-fever
#20
Filiz Türe Özdemir, Emel Ekşioğlu Demiralp, Sibel Z Aydın, Pamir Atagündüz, Tülin Ergun, Haner Direskeneli
OBJECTIVE: The immune classification of Behçet's disease (BD) is still controversial. In this study, we aimed to compare the immune/inflammatory gene expressions in BD with those in familial Mediterranean fever (FMF), an autoinflammatory disorder with innate immune activation. MATERIAL AND METHODS: CD4+ T cells and CD14+ monocytes were isolated from the peripheral blood mononuclear cells of Behçet's disease patients (n=10), FMF (n=6) patients, and healthy controls (n=4) with microbeads, and then, the mRNA was isolated...
December 2016: European Journal of Rheumatology
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