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Neutrophil lymphocyte

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https://www.readbyqxmd.com/read/29341345/increase-in-neutrophil-after-r-tpa-thrombolysis-predicts-poor-functional-outcome-of-ischemic-stroke-a-longitudinal-study
#1
Jijun Shi, Hao Peng, Shoujiang You, Yuanyuan Liu, Jiaping Xu, Yingying Xu, Huihui Liu, Rongfang Shi, Yongjun Cao, Chun-Feng Liu
BACKGROUND: Neutrophil, a pivotal immune responder to ischemic brain insult, has been involved in neuroplasticity and increases after stroke. r-tPA, a promising treatment improving neuroplasticity, promotes neutrophil degranulation. However, the dynamic profile of neutrophil after r-tPA treatment and its effect on neurological recovery after stroke is not well studied. METHODS: We measured cell counts of neutrophil, lymphocyte, and their ratio (NLR) on admission and 24 hours after r-tPA infusion in 372 consecutively recruited acute ischemic stroke patients (mean age 64 years)...
January 17, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29339284/rbmti-6-attenuates-pathophysiological-and-inflammatory-parameters-of-induced-emphysema-in-mice
#2
Adriana Feliciano Alves Duran, Luana de Paiva Neves, Flavia Ribeiro Santos da Silva, Gabriel Capella Machado, Graziele Cristina Ferreira, Juliana D Lourenço, Aparecida Sadae Tanaka, Milton de Arruda Martins, Fernanda D T Q S Lopes, Sergio Daishi Sasaki
Protease/anti-protease imbalance is the main pathogenic mechanism of emphysema and protease inhibitors have been recognized as potential molecules to treat the disease conditions. In this work the rBmTI-6 first domain (rBmTI-6-D1), a recombinant Kunitz-type serine proteinase inhibitor, was used to verify its effect in prevention or minimization of PPE-induced emphysema in mice. C57BL/6 mice were submitted to a PPE-induced emphysema model and treated with rBmTI-6-D1 before the emphysema development. We showed that the rBmTI-6-D1 treatment was sufficient to avoid the loss of elastic recoil, an effective decrease in alveolar enlargement and in the number of macrophages and lymphocytes in bronchoalveolar lavage fluid...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29338337/significance-of-combined-preoperative-serum-alb-and-dnlr-for-diagnosis-of-pancreatic-cancer
#3
Jia-Xin Liu, Ang Li, Lin-Ying Zhou, Xi-Fen Liu, Zi-Hao Wei, Xiao-Zhong Wang, Hou-Qun Ying
AIM: To investigate diagnostic value of preoperative inflammatory biomarkers in pancreatic cancer (PCC). MATERIALS & METHODS: Preoperative circulating Alb/Fib ratio, neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte ratio and lymphocyte/monocyte ratio were detected and calculated in 226 PCC individuals, 232 healthy controls and 142 additional cancer controls. Receiver-operating characteristic curve and area under the curve (AUC) were used to evaluate the diagnostic efficacy of PCC...
January 17, 2018: Future Oncology
https://www.readbyqxmd.com/read/29338303/evaluation-of-preprocedural-laboratory-parameters-as-predictors-of-drug-eluting-stent-restenosis-in-coronary-chronic-total-occlusion-lesions
#4
Chenguang Li, Yi Shen, Rende Xu, Yuxiang Dai, Shufu Chang, Hao Lu, Zhaohui Dong, Jianxin Deng, Juying Qian, Junbo Ge
This retrospective, single-center study assessed the prognostic value of several emerging inflammatory markers as predictors of in-stent restenosis (ISR) after drug-eluting stent implantation for coronary chronic total occlusion (CTO) lesions. Consecutive patients (n = 416) who underwent successful percutaneous coronary intervention (PCI) for documented CTO lesions and with follow-up angiography were enrolled. Preprocedural high-sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) were analyzed...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29337962/the-relationship-between-right-sided-tumour-location-tumour-microenvironment-systemic-inflammation-adjuvant-therapy-and-survival-in-patients-undergoing-surgery-for-colon-and-rectal-cancer
#5
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
January 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29336998/developing-a-predictive-model-for-clinical-outcomes-of-advanced-non-small-cell-lung-cancer-patients-treated-with-nivolumab
#6
Wungki Park, Deukwoo Kwon, Diana Saravia, Amrita Desai, Fernando Vargas, Mohamed El Dinali, Jessica Warsch, Roy Elias, Young Kwang Chae, Dae Won Kim, Sean Warsch, Adrian Ishkanian, Chukwuemeka Ikpeazu, Raja Mudad, Gilberto Lopes, Mohammad Jahanzeb
INTRODUCTION: Despite significant improvement of clinical outcomes of advanced non-small-cell lung cancer (NSCLC) patients treated with immunotherapy, our knowledge of optimal biomarkers is still limited. PATIENTS AND METHODS: We retrospectively evaluated 159 advanced NSCLC patients in our institution treated with nivolumab after disease progression during platinum-based chemotherapy. We correlated several variables with progression-free survival (PFS) to develop the immunotherapy, Sex, Eastern Cooperative Oncology Group performance status, Neutrophil-to-lymphocyte ratio (NLR), and Delta NLR (iSEND) model...
December 21, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29336893/a-meta-analysis-of-the-utility-of-the-neutrophil-to-lymphocyte-ratio-in-predicting-survival-after-pancreatic-cancer-resection
#7
REVIEW
Nicholas G Mowbray, David Griffith, Mohammed Hammoda, Guy Shingler, Amir Kambal, Bilal Al-Sarireh
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is thought to reflect cancer disease burden. To assess the prognostic ability of the NLR on overall survival in patients with resectable, pancreatic cancer a meta-analysis of published literature was undertaken. METHOD: A systematic review was performed independently by two authors using PubMed, Ovid MEDLINE and Embase databases. Included studies detailed the pre-operative NLR and overall survival of pancreatic cancer patients...
January 11, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29336315/a-high-neutrophil-to-lymphocyte-ratio-prior-to-braf-inhibitor-treatment-is-a-predictor-of-poor-progression-free-survival-in-patients-with-metastatic-melanoma
#8
Antoine Finon, Julia Zaragoza, Hervé Maillard, Nathalie Beneton, Guido Bens, Mahtab Samimi, Agnès Caille, Laurent Machet
Some studies have shown that a high neutrophil/lymphocyte ratio (NLR) ≥4 before initiating ipilimumab treatment is an independent prognostic indicator of poor survival in patients with metastatic melanoma (MM). To determine whether the NLR before starting BRAF inhibitor (BRAFi) treatment in patients with (MM) is associated with progression-free survival (PFS). This retrospective study included 49 patients consecutively receiving BRAFi for MM between July 2012 and December 2014. Cox proportional hazards regression was used to analyse the relationship between NLR and other factors, such as lactate dehydrogenase (LDH), performance status, BRAFi as first- or second-line therapy, and corticosteroid intake with PFS...
January 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29336203/aberrant-interactions-of-peripheral-measures-and-neurometabolites-with-lipids-in-complex-regional-pain-syndrome-using-magnetic-resonance-spectroscopy-a-pilot-study
#9
Ye-Ha Jung, Hyeonjin Kim, So Yeon Jeon, Jeong Min Kwon, Dasom Lee, Soo-Hee Choi, Do-Hyung Kang
Background The aim of this study was to assess peripheral measures and central metabolites associated with lipids using magnetic resonance spectroscopy. Results Twelve patients with complex regional pain syndrome (CRPS) and 11 healthy controls participated. Using magnetic resonance spectroscopy, we measured the levels of lipid 13a (Lip13a) and lipid 09 (Lip09) relative to total creatine (tCr) levels in the right and left thalamus. We found negative correlations of Lip13a/tCr in the right thalamus with red blood cells or neutrophils, but a positive correlation between Lip13a/tCr and lymphocytes in the controls...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29335080/-clinical-characteristics-of-refractory-mycoplasma-pneumoniae-pneumonia-in-children
#10
Jiang-Jiang Xu, Lin-Hua Shu
OBJECTIVE: To provide a basis for early diagnosis and treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children by comparing the clinical characteristics of RMPP and general Mycoplasma pneumoniae pneumonia (MPP). METHODS: Children with MPP hospitalized between October 2015 and December 2016 were selected as study subjects. According to the diagnostic criteria, children were divided into RMPP group (n=152) and MPP group (n=551). The differences between the two groups in the basic situation, clinical manifestations, infection parameters and myocardial enzymes were compared...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29334857/association-of-neutrophil-lymphocyte-ratio-with-intravenous-immunoglobulin-treatment-in-children-with-guillain-barr%C3%A3-syndrome
#11
Ezgi Altuntas Hüner, Alper I Dai, Abdullah T Demiryürek
Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory polyneuropathy of the peripheral nervous system. The authors aimed to investigate whether the neutrophil/lymphocyte (N/L) and platelet/lymphocyte (P/L) ratios are the parameters that associated with the drug treatment or severity of GBS. Twenty-seven children with GBS were retrospectively analyzed from the medical records of patients who attended to the Pediatric Neurology Department of the Gaziantep University Hospital. Biochemical and hematologic parameters were measured...
February 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29334845/neutrophil-to-lymphocyte-ratio-and-mural-nodule-height-as-predictive-factors-for-malignant-intraductal-papillary-mucinous-neoplasms
#12
Yusuke Watanabe, Yusuke Niina, Kazuyoshi Nishihara, Takafumi Okayama, Sadafumi Tamiya, Toru Nakano
BACKGROUND: Accurate preoperative prediction for malignant IPMN is still challenging. The aim of this study was to investigate the validity of neutrophil-to-lymphocyte ratio (NLR) and mural nodule height (MNH) for predicting malignant intraductal papillary mucinous neoplasm (IPMN). METHODS: The medical records of 60 patients who underwent pancreatectomy for IPMN were retrospectively reviewed. RESULTS: NLR tended to be higher in malignant IPMN (median: 2...
January 15, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29334832/novel-mortality-markers-for-critically-ill-patients
#13
Hamit Yoldas, Ibrahim Karagoz, Muhammed Nur Ogun, Yusuf Velioglu, Isa Yildiz, Murat Bilgi, Abdullah Demirhan
AIM: Inflammatory markers, such as the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), derived from a complete blood count have recently attracted attention as potential markers of morbidity and mortality in various diseases. The aim of the present study was to assess the usefulness of the NLR and PLR as markers of hospital stay and mortality of patients in intensive care units (ICUs). METHODS: Patients treated in the ICU of our institution between October 2016 and August 2017 were enrolled in the study...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29334754/high-neutrophil-to-lymphocyte-ratio-is-associated-with-symptomatic-and-ruptured-thoracic-aortic-aneurysm
#14
Fabien Lareyre, Juliette Raffort, Duy Le, Hon Lai Chan, Thomas Le Houerou, Frédéric Cochennec, Joseph Touma, Pascal Desgranges
The predictive value of the neutrophil to lymphocyte ratio (NLR) has been demonstrated in several cardiovascular diseases. The aim of our study was to investigate the association between the preoperative NLR and aneurysm characteristics as well as 30-day postoperative morbidity and mortality in patients with thoracic aortic aneurysm (TAA) undergoing aortic surgical repair. Consecutive patients (n = 75) with TAA were retrospectively included over a 10-year period. Clinical characteristics, aneurysm characteristics, and 30-day postoperative outcome were recorded...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#15
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29333812/markers-of-inflammation-and-tolerance-development-in-allergic-proctocolitis
#16
Hikmet T Nacaroglu, Semiha Bahceci Erdem, Ersin Durgun, Sait Karaman, Cahit Baris Erdur, Canan S Unsal Karkmer, Demet Can
BACKGROUND: Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333081/innate-immunity-recovers-earlier-than-acquired-immunity-during-severe-postoperative-immunosuppression
#17
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Claudia Spies
Background: Postoperative immune suppression, particularly a loss of cell-mediated immunity, is commonly seen after surgery and is associated with worse outcome, i.e. delayed wound healing, infections, sepsis, multiple-organ failure and cancer recurrence. However, the recovery of immune cells focusing on differences between innate and acquired immunity during severe postoperative immunosuppression is not investigated. Methods: In this retrospective randomized controlled trial (RCT) subgroup analysis, 10 postoperatively immune suppressed patients after esophageal or pancreatic resection were analyzed...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29332609/investigation-of-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-mean-platelet-volume-in-patients-with-tinnitus
#18
B Ulusoy, K Bozdemir, M Akyol, H I Mişe, A Kutluhan, M H Korkmaz
OBJECTIVE: This study aimed to evaluate patients with tinnitus in terms of mean platelet volume and platelet distribution width, and to explore neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, recently reported in the literature as being possible inflammation markers. METHODS: This study comprised 64 tinnitus patients and 64 age-matched healthy controls. Statistical significance level was accepted as p < 0.05. RESULTS: Mean platelet volume (t = 3...
January 15, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29332485/relationship-between-neutrophil-lymphocyte-ratio-and-epicardial-fat-tissue-thickness-in-patients-with-newly-diagnosed-hypertension
#19
Mehmet Ali Derya, Vahit Demir, Huseyin Ede
Objective Epicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM). Methods Eighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29331737/hematology-reference-intervals-for-neonatal-holstein-calves
#20
Nikolaos Panousis, Nektarios Siachos, Georgios Kitkas, Emmanouil Kalaitzakis, Maria Kritsepi-Konstantinou, Georgios E Valergakis
Data regarding hematologic reference intervals (RI) for neonatal calves have not been published yet. The aims of this study were: a) to establish hematology RIs for neonatal Holstein calves, b) to compare them with the RIs for lactating cows, and c) to investigate the relationship of age and gender with the hematologic profile of calves. Two-hundred and fifty-four clinically healthy Holstein calves (1-9days old, from 30 farms) and 82 healthy Holstein cows (between 30 and 150days in milk, from 10 farms) were blood sampled once for a complete blood count evaluation, using the ADVIA 120 hematology analyzer...
January 9, 2018: Research in Veterinary Science
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