Dongyu Li, Shaojun Liu, Tingting Yu, Zhang Liu, Silin Sun, Denis Bragin, Alexander Shirokov, Nikita Navolokin, Olga Bragina, Zhengwu Hu, Jürgen Kurths, Ivan Fedosov, Inna Blokhina, Alexander Dubrovski, Alexander Khorovodov, Andrey Terskov, Maria Tzoy, Oxana Semyachkina-Glushkovskaya, Dan Zhu
Intraventricular hemorrhage is one of the most fatal forms of brain injury that is a common complication of premature infants. However, the therapy of this type of hemorrhage is limited, and new strategies are needed to reduce hematoma expansion. Here we show that the meningeal lymphatics is a pathway to remove red blood cells from the brain's ventricular system of male human, adult and newborn rodents and is a target for non-invasive transcranial near infrared photobiomodulation. Our results uncover the clinical significance of phototherapy of intraventricular hemorrhage in 4-day old male rat pups that have the brain similar to a preterm human brain...
September 29, 2023: Nature Communications