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https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#1
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28186867/significant-improvement-in-cognition-in-mild-to-moderately-severe-dementia-cases-treated-with-transcranial-plus-intranasal-photobiomodulation-case-series-report
#2
Anita E Saltmarche, Margaret A Naeser, Kai Fai Ho, Michael R Hamblin, Lew Lim
OBJECTIVE: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10-24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. BACKGROUND: Animal studies have presented the potential of PBM for AD. Dysregulation of the brain's default mode network (DMN) has been associated with AD, presenting the DMN as an identifiable target for PBM...
February 10, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28049075/abnormal-brain-oscillations-persist-after-recovery-from-bipolar-depression
#3
P Canali, S Casarotto, M Rosanova, G Sferrazza-Papa, A G Casali, O Gosseries, M Massimini, E Smeraldi, C Colombo, F Benedetti
When directly perturbed in healthy subjects, premotor cortical areas generate electrical oscillations in the beta range (20-40Hz). In schizophrenia, major depressive disorder and bipolar disorder (BD), these oscillations are markedly reduced, in terms of amplitude and frequency. However, it still remains unclear whether these abnormalities can be modulated over time, or if they can be still observed after treatment. Here, we employed transcranial magnetic stimulation (TMS) combined with EEG to assess the frontal oscillatory activity in eighteen BD patients before/after antidepressant treatments (sleep deprivation and light therapy), relative to nine healthy controls...
December 27, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28001759/transcranial-low-level-laser-light-therapy-for-brain-injury
#4
Connor Thunshelle, Michael R Hamblin
BACKGROUND: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). METHODS: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28001756/transcranial-red-near-infrared-light-emitting-diode-therapy-to-improve-cognition-in-chronic-traumatic-brain-injury
#5
Margaret A Naeser, Paula I Martin, Michael D Ho, Maxine H Krengel, Yelena Bogdanova, Jeffrey A Knight, Megan K Yee, Ross Zafonte, Judith Frazier, Michael R Hamblin, Bang-Bon Koo
We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27635607/-possibilities-of-non-drug-treatment-for-parkinson-s-disease
#6
REVIEW
D V Pokhabov, V G Abramov, D D Pokhabov
In this article, non-drug methods of treatment of Parkinson's disease are reviewed. Particular attention is given to the motor symptoms of disease, specifically to gait disorders. Information about objective methods of gait impairment is presented. Own results that confirm the effect of a method of tempo-rhythmical correction of walk in patients with Parkinson's disease (PD) and vascular parkinsonism as well as a device for assessment of gait parameters developed by the authors are analyzed. The efficacy of other methods of gait correction using external cues, study design and level of evidence are analyzed as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27367569/therapeutic-effects-of-10-hzpulsed-wave-lasers-in-rat-depression-model-a-comparison-between-near-infrared-and-red-wavelengths
#7
Farzad Salehpour, Seyed Hossein Rasta, Gisou Mohaddes, Saeed Sadigh-Eteghad, Sima Salarirad
BACKGROUND AND OBJECTIVE: The application of transcranial low-level light/laser therapy (tLLLT) in the range of red to near-infrared (NIR) spectrum for psychological disorders is a new area that is attracting growing interest in recent years. The photomodulation effects of NIR and red coherent lights on the activity of cytochrome c oxidase in neuronal cells of brain have been recently introduced. This study, therefore, sought to compare the therapeutic effects of 10-Hz pulsed wave NIR (810 nm) laser with red (630 nm) laser using the same delivered energy density and Citalopram in rat chronic mild stress (CMS) model of depression and anxiety...
September 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27267860/transcranial-laser-stimulation-as-neuroenhancement-for-attention-bias-modification-in-adults-with-elevated-depression-symptoms
#8
Seth G Disner, Christopher G Beevers, Francisco Gonzalez-Lima
BACKGROUND: Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy has been inconclusive. Adjunctive neuroenhancement to augment clinical effectiveness has shown promise, particularly for individuals who respond positively to the primary intervention...
September 2016: Brain Stimulation
https://www.readbyqxmd.com/read/26989758/review-of-transcranial-photobiomodulation-for-major-depressive-disorder-targeting-brain-metabolism-inflammation-oxidative-stress-and-neurogenesis
#9
REVIEW
Paolo Cassano, Samuel R Petrie, Michael R Hamblin, Theodore A Henderson, Dan V Iosifescu
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder (MDD). While still experimental, preliminary data on the use of PBM for brain disorders are promising. PBM is low-cost with potential for wide dissemination; further research on PBM is sorely needed. We found clinical and preclinical studies via PubMed search (2015), using the following keywords: "near-infrared radiation," "NIR," "low-level light therapy," "low-level laser therapy," or "LLLT" plus "depression...
July 2016: Neurophotonics
https://www.readbyqxmd.com/read/26920546/shining-light-on-the-sprout-of-life-optogenetics-applications-in-stem-cell-research-and-therapy
#10
REVIEW
Hadi Mirzapour Delavar, Arezou Karamzadeh, Saghar Pahlavanneshan
Optogenetics is the integration of genetics and optics to achieve gain or loss of function of well-defined events in specific cells of living tissue. As a versatile tool, upon light illumination, it allows fast control of precisely defined events in biological systems from single cell to different parts of whole tissue in freely moving animals. Taking advantage of this method, a multitude of studies have been published to understand brain functions and dysfunctions. Although from the beginning, it has been used to target neurons within the neural networks and to understand how specific neurons contribute to brain function, it gradually has been extended to other fields of biology such as stem cell research and therapy...
June 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/26889965/pre-conditioning-with-transcranial-low-level-light-therapy-reduces-neuroinflammation-and-protects-blood-brain-barrier-after-focal-cerebral-ischemia-in-mice
#11
Hae In Lee, Jung Hwa Park, Min Young Park, Nam Gyun Kim, Kyoung-Jun Park, Byung Tae Choi, Yong-Ii Shin, Hwa Kyoung Shin
PURPOSE: Transcranial low-level light therapy (LLLT) has gained interest as a non-invasive, inexpensive and safe method of modulating neurological and psychological functions in recent years. This study was designed to examine the preventive effects of LLLT via visible light source against cerebral ischemia at the behavioral, structural and neurochemical levels. METHODS: The mice received LLLT twice a day for 2 days prior to photothrombotic cortical ischemia. RESULTS: LLLT significantly reduced infarct size and edema and improved neurological and motor function 24 h after ischemic injury...
2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/26835486/transcranial-low-level-laser-therapy-810%C3%A2-nm-temporarily-inhibits-peripheral-nociception-photoneuromodulation-of-glutamate-receptors-prostatic-acid-phophatase-and-adenosine-triphosphate
#12
Marcelo Victor Pires de Sousa, Cleber Ferraresi, Masayoshi Kawakubo, Beatriz Kaippert, Elisabeth Mateus Yoshimura, Michael R Hamblin
Photobiomodulation or low-level light therapy has been shown to attenuate both acute and chronic pain, but the mechanism of action is not well understood. In most cases, the light is applied to the painful area, but in the present study we applied light to the head. We found that transcranial laser therapy (TLT) applied to mouse head with specific parameters (810 nm laser, [Formula: see text], 7.2 or [Formula: see text]) decreased the reaction to pain in the foot evoked either by pressure (von Frey filaments), cold, or inflammation (formalin injection) or in the tail (evoked by heat)...
January 2016: Neurophotonics
https://www.readbyqxmd.com/read/26817446/transcranial-laser-stimulation-improves-human-cerebral-oxygenation
#13
Fenghua Tian, Snehal N Hase, F Gonzalez-Lima, Hanli Liu
BACKGROUND AND OBJECTIVE: Transcranial laser stimulation of the brain with near-infrared light is a novel form of non-invasive photobiomodulation or low-level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near-infrared spectroscopy (fNIRS)...
April 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/26535475/spect-perfusion-imaging-demonstrates-improvement-of-traumatic-brain-injury-with-transcranial-near-infrared-laser-phototherapy
#14
Theodore A Henderson, Larry D Morries
Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. Near-infrared (NIR) light has shown benefits in animal models and human trials for stroke and in animal models for TBI. Diodes emitting low-level NIR often have lacked therapeutic efficacy, perhaps failing to deliver sufficient radiant energy to the necessary depth. In this case report, a patient with moderate TBI documented in anatomical magnetic resonance imaging (MRI) and perfusion single-photon emission computed tomography (SPECT) received 20 NIR treatments in the course of 2 mo using a high-power NIR laser...
2015: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/26463915/transcranial-near-infrared-laser-therapy-for-stroke-how-to-recover-from-futility-in-the-nest-3-clinical-trial
#15
Paul A Lapchak, Paul D Boitano
Development of drugs and devices for the treatment of stroke is not exempt from current translational research standards, which include Stroke Treatment Academic Industry Roundtable (STAIR) criteria and RIGOR guidelines. Near-infrared laser therapy (NILT) was developed to treat stroke in an era when STAIR criteria were not adhered to, thus NILT was not optimized in multiple species, nor was it optimized for efficacy across barriers in translational animal models before proceeding to expensive and extensive clinical trials...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/26347062/treatments-for-traumatic-brain-injury-with-emphasis-on-transcranial-near-infrared-laser-phototherapy
#16
REVIEW
Larry D Morries, Paolo Cassano, Theodore A Henderson
Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. In this review, treatments for the chronic TBI patient are discussed, including pharmaceuticals, nutraceuticals, cognitive therapy, and hyperbaric oxygen therapy. All available literature suggests a marginal benefit with prolonged treatment courses. An emerging modality of treatment is near-infrared (NIR) light, which has benefit in animal models of stroke, spinal cord injury, optic nerve injury, and TBI, and in human trials for stroke and TBI...
2015: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/26110109/neuroimaging-and-neuromodulation-approaches-to-study-eating-behavior-and-prevent-and-treat-eating-disorders-and-obesity
#17
REVIEW
D Val-Laillet, E Aarts, B Weber, M Ferrari, V Quaresima, L E Stoeckel, M Alonso-Alonso, M Audette, C H Malbert, E Stice
Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain...
2015: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26048614/cerebral-vascular-injury-in-traumatic-brain-injury
#18
REVIEW
Kimbra Kenney, Franck Amyot, Margalit Haber, Angela Pronger, Tanya Bogoslovsky, Carol Moore, Ramon Diaz-Arrastia
Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and TBI-related chronic disability. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature is a component of the neurovascular unit (NVU) coupling neuronal metabolism with local cerebral blood flow...
January 2016: Experimental Neurology
https://www.readbyqxmd.com/read/26039354/transcranial-near-infrared-laser-transmission-nilt-profiles-800-nm-systematic-comparison-in-four-common-research-species
#19
COMPARATIVE STUDY
Paul A Lapchak, Paul D Boitano, Pramod V Butte, David J Fisher, Thilo Hölscher, Eric J Ley, Miriam Nuño, Arne H Voie, Padmesh S Rajput
BACKGROUND AND PURPOSE: Transcranial near-infrared laser therapy (TLT) is a promising and novel method to promote neuroprotection and clinical improvement in both acute and chronic neurodegenerative diseases such as acute ischemic stroke (AIS), traumatic brain injury (TBI), and Alzheimer's disease (AD) patients based upon efficacy in translational animal models. However, there is limited information in the peer-reviewed literature pertaining to transcranial near-infrared laser transmission (NILT) profiles in various species...
2015: PloS One
https://www.readbyqxmd.com/read/26017772/improving-executive-function-using-transcranial-infrared-laser-stimulation
#20
Nathaniel J Blanco, W Todd Maddox, Francisco Gonzalez-Lima
Transcranial infrared laser stimulation is a new non-invasive form of low-level light therapy that may have a wide range of neuropsychological applications. It entails using low-power and high-energy-density infrared light from lasers to increase metabolic energy. Preclinical work showed that this intervention can increase cortical metabolic energy, thereby improving frontal cortex-based memory function in rats. Barrett and Gonzalez-Lima (2013, Neuroscience, 230, 13) discovered that transcranial laser stimulation can enhance sustained attention and short-term memory in humans...
May 28, 2015: Journal of Neuropsychology
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