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https://www.readbyqxmd.com/read/27905993/pregnant-women-s-perceptions-of-exposure-to-brominated-flame-retardants
#1
A Lane, C G Goodyer, F Rab, J M Ashley, S Sharma, A Hodgson, J Nisker
BACKGROUND: Recent media reports on human studies associating brominated flame retardants (BFRs) in household products in pregnancy with urogenital anomalies in boys and endocrine disruption in both sexes. We sought to explore the perceptions of pregnant women of brominated flame retardant (BFR) exposure, in light of recent media reports on the adverse health effects of BFR exposure prenatally. METHODS: Pregnant women were recruited for interviews through posters and pamphlets in prenatal clinics, prenatal fairs and community centres...
December 1, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27884470/the-first-exposure-assessment-of-legacy-and-unrestricted-brominated-flame-retardants-in-predatory-birds-of-pakistan
#2
Naeem Akhtar Abbasi, Igor Eulaers, Veerle Leontina Bernard Jaspers, Muhammad Jamshed Iqbal Chaudhry, Adrien Frantz, Per Lennart Ambus, Adrian Covaci, Riffat Naseem Malik
The exposure to legacy polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDDs) and unrestricted 1,2-bis (2,4,6-tribromophenoxy) ethane (BTBPE), bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromo-benzoate (EH-TBB) was examined in tail feathers of 76 birds belonging to ten predatory species inhabiting Pakistan. In addition, different feather types of six individuals of Black kite (Milvus migrans) were compared for their brominated flame retardant (BFR) levels...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27837041/acute-effects-of-resistance-exercise-with-continuous-and-intermittent-blood-flow-restriction-on-hemodynamic-measurements-and-perceived-exertion
#3
Gabriel R Neto, Jefferson S Novaes, Verônica P Salerno, Michel M Gonçalves, Bruna K L Piazera, Thais Rodrigues-Rodrigues, Maria S Cirilo-Sousa
This study compared the acute effects of low-intensity resistance exercise (RE) sessions for the upper limb with continuous and intermittent blood flow restriction (BFR) and high-intensity RE with no BFR on lactate, heart rate, double product (DP; heart rate times systolic blood pressure), and perceived exertion (RPE). Ten recreationally trained men (1-5 years strength training; age mean = 19 ± 0.82 years) performed three experimental protocols in random order: (a) low-intensity RE at 20% one-repetition maximum (1RM) with intermittent BFR (LI + IBFR), (b) low-intensity RE at 20% 1RM with continuous BFR (LI + CBFR), and (c) high-intensity RE at 80% 1RM...
November 11, 2016: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/27833648/alternative-drugs-go-global-possible-lead-and-or-mercury-intoxication-from-imported-natural-health-products-and-a-need-for-scientifically-evaluated-poisoning-monitoring-from-environmental-exposures
#4
Lygia Therese Budnik, Xaver Baur, Volker Harth, Axel Hahn
BACKGROUND: With increases in globalization, cultural remedies from Chinese, Ayurvedic, Arab and other traditions have become more available to international consumers, offering unfamiliar "Natural Health Products" (NHP), used as alternative medicine or supplementary medicine. Contamination with toxic ingredients including lead, mercury, arsenic, and other toxic elements has been documented in several of these products from various parts of the globe, particularly from some parts of Asia and the Orient...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/27826654/physiological-responses-to-interval-endurance-exercise-at-different-levels-of-blood-flow-restriction
#5
Rogério B Corvino, Harry B Rossiter, Thiago Loch, Jéssica C Martins, Fabrizio Caputo
PURPOSE: We aimed to identify a blood flow restriction (BFR) endurance exercise protocol that would both maximize cardiopulmonary and metabolic strain, and minimize the perception of effort. METHODS: Twelve healthy males (23 ± 2 years, 75 ± 7 kg) performed five different exercise protocols in randomized order: HI, high-intensity exercise starting at 105% of the incremental peak power (P peak); I-BFR30, intermittent BFR at 30% P peak; C-BFR30, continuous BFR at 30% P peak; CON30, control exercise without BFR at 30% P peak; I-BFR0, intermittent BFR during unloaded exercise...
November 8, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27796050/inflammatory-bowel-disease-in-a-rodent-model-alters-osteocyte-protein-levels-controlling-bone-turnover
#6
Corinne E Metzger, A Narayanan, D C Zawieja, S A Bloomfield
Bone loss is a common comorbidity of inflammatory bowel disease (IBD), leading to elevated fracture risk in these patients. Inflammatory factors associated with IBD cause increased bone resorption and decreased bone formation with multiple factors implicated as instigators of these alterations. In this project, we examined the influence of IBD on osteocytes proteins in male rats (2 months old) divided into two groups: induced gut inflammation via TNBS enema and vehicle control. We examined the prevalence of two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), an anti-inflammatory cytokine, interleukin-10 (IL-10), the anabolic factor insulin-like growth factor-I (IGF-I), osteoclastogenesis regulators RANKL and OPG, and the bone formation inhibitor sclerostin in osteocytes in three bone compartments 4 weeks after initiation of gut inflammation...
October 31, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27770890/osseointegration-is-improved-by-coating-titanium-implants-with-a-nanostructured-thin-film-with-titanium-carbide-and-titanium-oxides-clustered-around-graphitic-carbon
#7
Francesca Veronesi, Gianluca Giavaresi, Milena Fini, Giovanni Longo, Caterina Alexandra Ioannidu, Anna Scotto d'Abusco, Fabiana Superti, Gianluca Panzini, Carlo Misiano, Alberto Palattella, Paolo Selleri, Nicola Di Girolamo, Viola Garbarino, Laura Politi, Roberto Scandurra
Titanium implants coated with a 500nm nanostructured layer, deposited by the Ion Plating Plasma Assisted (IPPA) technology, composed of 60% graphitic carbon, 25% titanium oxides and 15% titanium carbide were implanted into rabbit femurs whilst into the controlateral femurs uncoated titanium implants were inserted as control. At four time points the animals were injected with calcein green, xylenol orange, oxytetracycline and alizarin. After 2, 4 and 8weeks femurs were removed and processed for histology and static and dynamic histomorphometry for undecalcified bone processing into methylmethacrylate, sectioned, thinned, polished and stained with Toluidine blue and Fast green...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27749358/blood-flow-restriction-training-after-knee-arthroscopy-a-randomized-controlled-pilot-study
#8
David J Tennent, Christina M Hylden, Anthony E Johnson, Travis C Burns, Jason M Wilken, Johnny G Owens
INTRODUCTION: Quadriceps strength after arthroscopic knee procedures is frequently diminished several years postoperation. Blood flow restriction (BFR) training uses partial venous occlusion while performing submaximal exercise to induce muscle hypertrophy and strength improvements. The purpose of this study was to evaluate BFR as a postoperative therapeutic intervention after knee arthroscopy. METHODS: A randomized controlled pilot study comparing physical therapy with and without BFR after knee arthroscopy was conducted...
October 5, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/27743851/perfluorinated-alkylated-substances-and-brominated-flame-retardants-in-serum-of-the-czech-adult-population
#9
Lenka Sochorová, Lenka Hanzlíková, Milena Černá, Anna Drgáčová, Alena Fialová, Andrea Švarcová, Tomáš Gramblička, Jana Pulkrabová
Persistent organic pollutants, such as perfluorinated alkylated substances (PFASs) and brominated flame retardants (BFRs) are widespread in the environment and most of them are bioaccumulated in wildlife and humans. The present study is the first investigation to reveal the PFAS and BFR levels of serum samples in the adult population of the Czech Republic. Altogether, 300 serum samples from blood donors in four cities were examined. In all samples 19 PFASs and 33 BFRs, including some of their metabolites, were targeted...
September 28, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27730736/let-s-talk-about-sex-where-are-the-young-females-in-blood-flow-restriction-research
#10
Brittany R Counts, Lindy M Rossow, Kevin T Mattocks, J Grant Mouser, Matthew B Jessee, Samuel L Buckner, Scott J Dankel, Jeremy P Loenneke
Low-load resistance exercise with the blood flow restriction (BFR) has been shown to increase muscle size similar to that of traditional high-load resistance training. Throughout the BFR literature, there is a vast difference between the quantity of young females included in the literature compared to young males, older males and older females. Therefore, the purpose of this minireview is to discuss the underrepresentation of young females in the BFR literature and review the potential physiologic reasons as to why they may have been excluded...
October 11, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27714423/scientific-principles-for-the-identification-of-endocrine-disrupting-chemicals-a-consensus-statement
#11
Roland Solecki, Andreas Kortenkamp, Åke Bergman, Ibrahim Chahoud, Gisela H Degen, Daniel Dietrich, Helmut Greim, Helen Håkansson, Ulla Hass, Trine Husoy, Miriam Jacobs, Susan Jobling, Alberto Mantovani, Philip Marx-Stoelting, Aldert Piersma, Vera Ritz, Remy Slama, Ralf Stahlmann, Martin van den Berg, R Thomas Zoeller, Alan R Boobis
Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic chemicals, known as "endocrine disruptors" (EDs), trigger adverse health effects by disrupting the endogenous hormone system. There is need to harmonize guidance on the regulation of EDs, but this has been hampered by what appeared as a lack of consensus among scientists. This publication provides summary information about a consensus reached by a group of world-leading scientists that can serve as the basis for the development of ED criteria in relevant EU legislation...
October 6, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27668404/repeated-blood-flow-restriction-induces-muscle-fiber-hypertrophy
#12
Mizuki Sudo, Soichi Ando, Yutaka Kano
INTRODUCTION: We recently developed an animal model to investigate the effects of eccentric contraction (ECC) and blood flow restriction (BFR) on muscle tissue at the cellular level. This study clarified the effects of repeated BFR, ECC, and BFR combined with ECC (BFR+ECC) on muscle fiber hypertrophy. METHODS: Male Wistar rats were assigned to 3 groups: BFR, ECC, and BFR+ECC. The contralateral leg in the BFR group served as a control (CONT). Muscle fiber cross sectional area (CSA) of the tibialis anterior was determined after the respective treatments for 6 weeks...
September 26, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27634603/blood-flow-restricted-exercise-compared-to-high-load-resistance-exercise-during-unloading
#13
Kyle J Hackney, Meghan E Downs, Lori Ploutz-Snyder
BACKGROUND: Bed rest studies have shown that high load (HL) resistance training can mitigate the loss of muscle size and strength during musculoskeletal unloading; however, not all individuals are able to perform HL resistance exercise. Blood flow restricted (BFR) resistance exercise may be a novel way to prevent maladaptation to unloading without requiring HL exercise equipment. This study evaluated the muscular training adaptations to HL and BFR resistance training during unilateral lower limb suspension (ULLS), a human limb unloading model...
August 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27613141/transcriptional-profiling-of-rat-skeletal-muscle-hypertrophy-under-restriction-of-blood-flow
#14
Shouyu Xu, Xueyun Liu, Zhenhuang Chen, Gaoquan Li, Qin Chen, Guoqing Zhou, Ruijie Ma, Xinmiao Yao, Xiao Huang
Blood flow restriction (BFR) under low-intensity resistance training (LIRT) can produce similar effects upon muscles to that of high-intensity resistance training (HIRT) while overcoming many of the restrictions to HIRT that occurs in a clinical setting. However, the potential molecular mechanisms of BFR induced muscle hypertrophy remain largely unknown. Here, using a BFR rat model, we aim to better elucidate the mechanisms regulating muscle hypertrophy as induced by BFR and reveal possible clinical therapeutic targets for atrophy cases...
December 15, 2016: Gene
https://www.readbyqxmd.com/read/27608912/porous-tantalum-seeded-with-bone-marrow-mesenchymal-stem-cells-attenuates-steroid-associated-osteonecrosis
#15
W-M Fu, L Yang, B-J Wang, J-K Xu, J-L Wang, L Qin, D-W Zhao
OBJECTIVE: Bone marrow mesenchymal stem cells (BMMSCs) have been widely applied in osteonecrosis. However, lack of biomechanical support limited application of BMMSCs. And porous tantalum (PTA) has been identified as a cell-friendly scaffold for bone regeneration. Herein, we aimed to investigate the efficacy of PTA seeded with BMMSCs in the treatment of osteonecrosis. MATERIALS AND METHODS: After the production of PTA seeded with BMMSCs, MTT and GFP were performed to identify the proliferation and adhesion of BMMSCs respectively, which was further examined by scanning electron microscopy (SEM)...
August 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27600263/applicability-of-gas-chromatography-gc-coupled-to-triple-quadrupole-qqq-tandem-mass-spectrometry-ms-ms-for-polybrominated-diphenyl-ether-pbde-and-emerging-brominated-flame-retardant-bfr-determinations-in-functional-foods-enriched-in-omega-3
#16
Ángel García-Bermejo, Susana Mohr, Laura Herrero, María-José González, Belén Gómara
This paper reports on the optimization, characterization, and applicability of gas chromatography coupled to triple-quadrupole tandem mass spectrometry (GC-QqQ(MS/MS)) for the determination of 14 polybrominated diphenylethers (PBDEs) and 2 emerging brominated flame retardants, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and decabromodiphenylethane (DBDPE), in functional food samples. The method showed satisfactory precision and linearity with instrumental limits of detection (iLODs) ranging from 0.12 to 7...
September 28, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27595282/bendamustine-added-to-allogeneic-conditioning-improves-long-term-outcomes-in-patients-with-cll
#17
I F Khouri, D Sui, E J Jabbour, B I Samuels, F Turturro, G Alatrash, P Anderlini, S Ahmed, B Oran, S O Ciurea, D Marin, A Olson, K K Patel, U R Popat, C Ledesma, T M Kadia, A Ferrajoli, J A Burger, J L Jorgensen, L J Medeiros, R L Bassett, A M Gulbis
Bendamustine has shown a favorable safety profile when included in chemotherapy regimens for several types of lymphoma, including CLL. This study investigated the long-term effect of adding bendamustine to a conditioning regimen on survival, rate of engraftment, immune recovery and GvHD after allogeneic stem cell transplantation (alloSCT) in CLL patients. These outcomes were compared with the fludarabine, cyclophosphamide and rituximab (FCR) conditioning regimen. We reviewed the data for 89 CLL patients treated on three trials at our institution...
September 5, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27591369/critical-review-of-the-analysis-of-brominated-flame-retardants-and-their-environmental-levels-in-africa
#18
Martin Brits, Jayne de Vos, Jana M Weiss, Egmont R Rohwer, Jacob de Boer
World-wide, the prevalence of brominated flame retardants (BFRs) is well documented for routine analysis of environmental and biological matrices. There is, however, limited information on these compounds in the African environment and insufficient information on the analytical approaches used to obtain data. This paper presents a review on BFR levels in the African environment and the various analytical methodologies specifically applied in Africa for polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls and alternative-BFRs...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27577555/francisella-tularensis-live-vaccine-strain-deficient-in-capb-and-overexpressing-the-fusion-protein-of-igla-iglb-and-iglc-from-the-bfr-promoter-induces-improved-protection-against-f-tularensis-respiratory-challenge
#19
Qingmei Jia, Richard Bowen, Bai-Yu Lee, Barbara Jane Dillon, Saša Masleša-Galić, Marcus A Horwitz
A safer and more effective vaccine than the unlicensed Francisella tularensis Live Vaccine Strain (LVS) is needed to protect against the biowarfare agent F. tularensis. Previously, we developed an LVS ΔcapB mutant that is significantly safer than LVS and provides potent protective immunity against F. tularensis respiratory challenge when administered intranasally but limited protection when administered intradermally unless as part of a prime-boost vaccination strategy. To improve the immunogenicity and efficacy of LVS ΔcapB, we developed recombinant LVS ΔcapB (rLVS ΔcapB) strains overexpressing various F...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27574326/role-of-the-free-radicals-in-mechanisms-of-gallstone-formation-an-epr-study
#20
T Sanikidze, E Chikvaidze
The mechanism of gallstone formation is not well understood. Abnormal regulation of hepatic cholesterol, bile acid synthesis or esterification, deposition of cholesterol monohydrate crystals and gall bladder dysfunction are thought to be the principal metabolic aberrations that may cause gallstone formation. One plausible mechanism leading to these abnormalities is the role of free radicals, whose presence can be investigated using Electron Paramagnetic Resonance (EPR). Surgically removed gall bladder stones were used to obtain purified bilirubin, which was irradiated in vitro with visible light and measured with EPR in the presence of and without oxygen...
August 29, 2016: Radiation Protection Dosimetry
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