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cryptoccocal meningitis

Saeed Arif, Khushbakht Ghazanfar, Waseem Wali Muhammad, Hamza Malik
Cryptococcal meningitis (CM) is life threatening fungal infection of central nervous system (CNS). Although it is commonly associated with immunosuppression but rarely it can occur in immune competent patient. We report a case of 21 year old non HIV infected girl. Based on initial diagnoses of tuberculosis Bacillus meningitis (TBM), she was started on anti-tuberculosis treatment (ATT). However failure to respond to treatment prompted a quest for alternative diagnosis. A final Diagnosis of CM was confirmed on latex agglutination antigen detection on cerebrospinal fluid (CSF) analysis...
October 2015: Journal of Ayub Medical College, Abbottabad: JAMC
T Kammalac Ngouana, J Dongtsa, C Kouanfack, C Tonfack, S Fomena, M Mallié, E Delaporte, F-Fekam Boyom, S Bertout
Cryptococcal meningitis is a mycosis encountered especially in patients with Acquired Immunodeficiency Syndrome and is fatal in the absence of treatment. Information on epidemiology, diagnosis and susceptibility profile to antifungal drugs, are scarce in Cameroon. Authors evaluated the diagnosis possibilities of the cryptococcal meningitis in Cameroon, and studied the antifungal susceptibility of isolated strains to fluconazole, used as first line treatment of the disease in Cameroon. Between December 2009 and July 2011, 146 cerebrospinal fluids obtained from HIV patients with suspicion of meningitis were analysed...
March 2015: Journal de Mycologie Médicale
Mohammed Moizuddin, Mohammed Nayeem, Muhammed Imtiaz, Ria Gripaldo
Infectious Disease Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: A high index of suspicion is critical for diagnosis of pulmonary cryptococcal infection in immunocompetent patients. Occasionally, just a radiological demonstration of a non-specific peripheral pulmonary opacity may draw attention to the disease. We report a rare case of 51-year old non-HIV female who presented with headaches and pulmonary mass and was diagnosed with disseminated cryptococcal infection...
October 1, 2014: Chest
George Stilwell, Hugo Pissarra
BACKGROUND: Cryptococcus spp. are saprophytic and opportunistic fungal pathogens that are known to cause severe disease in immunocompromised animals. In goats there are reports of clinical cryptococcal pneumonia and mastitis but not of meningitis. CASE PRESENTATION: The following report describes a case of a five year old buck showing severe neurological signs, including paraplegia and strong pain reaction to touch of the hindquarters region. Treatment with antibiotics was unsuccessful and the animal was euthanized for humanitarian reasons...
2014: BMC Veterinary Research
Ivica Pavić, Durdica Cekinović, Josip Begovac, Tomislav Maretić, Rok Civljak, Biserka Troselj-Vukić
Cryptococcus neoformans is a leading cause of invasive cryptoccocal infections which include meningitis/meningoencephalitis, cerebral cryptococcoma, invasive pulmonary and mediastinal infection. Invasive infection is mainly diagnosed in immunocompromised patients, especially in HIV-infected individuals. There is a rising number of patients with invasive cryptococcal infections in immunocompromised patients who are HIV-negative. Among several primary immunodeficiency syndromes, considered as possible reasons for these invasive infections, idiopathic CD4+ T lymphocytopenia (ICL) is most frequently diagnosed...
June 2013: Collegium Antropologicum
Shaik Afshan Jabeen, Aruna Murthy, Rukmini Mridula Kandadai, A K Meena, Rupam Borgohain, Megha S Uppin
Opportunistic infections usually occur in patients with an immunocompromised state, and can be severe. Cryptoccocal meningitis is a fatal condition if left untreated, and is usually found in such patients. We report the case of an adult patient with cryptoccocal meningitis secondary to intestinal lymphangiectasia. A 30 year old female was admitted to our hospital for meningitis. Biochemical and radiological investigations were performed. A cerebrospinal fluid latex agglutination test showed positive cryptoccocal antigen...
July 2012: Annals of Indian Academy of Neurology
E F Aoussi, E Ehui, J P Dembélé, P Kolia-Diafouka, N F Elloh, S I Ouattara, K A Tanon, A Doumbia, K D Adou-Bryn, S P Eholié, E Bissagnéné
OBJECTIVE: The authors had for aim to describe the management of cryptococcal meningitis in HIV infected adults, in Ivory Coast. PATIENTS AND METHODS: A retrospective study was made from January 1, 2005 to December 31, 2008 on the files of consecutive hospitalized patients presenting with cryptococcal meningitis, at the Treichville University Hospital, Infectious and tropical diseases department (Abidjan). The socio-demographic, clinical, and biological aspects as well as the outcome were analyzed...
August 2012: Médecine et Maladies Infectieuses
S Mohammad-Khani, B Otremba, R Klein, H H Capelle, F Logemann, F C Bange, R E Schmidt, M Stoll
Cryptococcus neoformans is the most common cause of life threatening meningoencephalitis in HIV-infected patients. Diagnosis is based on tests for cryptoccocal antigen in serum and cerebrospinal fluid, and on culture of the organism. We present a case of AIDS-related cryptococcal meningoencephalitis unresponsive to antifungal combination therapy, despite of evidence of fungal susceptibility in vitro. Significant decreases in cryptococcal antigen titers in serum and cerebrospinal fluid did not correlate with progress in disease and fatal outcome...
November 25, 2010: European Journal of Medical Research
Suthat Chottanapund, Pratap Singhasivanon, Jaranit Kaewkungwal, Kanittha Chamroonswasdi, Weerawat Manosuthi
OBJECTIVE: To study survival time and risk factors of mortality among HIV-infected patients who had cryptococcal meningitis. DESIGN: Retrospective cohort study. MATERIAL AND METHOD: Patients' medical records of those who had HIV-infection with newly diagnosed cryptoccocal meningitis between January 2002 and December 2004 were reviewed. Each patient was classified into one of two groups, according to their anti-retroviral status (ART). RESULTS: Five hundred and forty nine patients enrolled in the present study: 281 (51...
October 2007: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
M Maschke, O Kastrup, S Esser, B Ross, U Hengge, A Hufnagel
OBJECTIVE: To determine the change of incidence and prevalence of neurological disorders caused by the human immunodeficiency virus (HIV) and opportunistic infections in HIV positive patients under treatment since the introduction of highly active antiretroviral therapy (HAART). METHODS: The data of all HIV infected patients were retrospectively analysed, who were examined in the HIV outpatients clinic of the neurological department of the University Clinic Essen between 1995 and 1998 (n=563, total number of visits=735)...
September 2000: Journal of Neurology, Neurosurgery, and Psychiatry
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