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Coagulase-negative staphylococci

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https://www.readbyqxmd.com/read/28229205/-spectrum-of-pathogens-in-postoperative-complications-of-visceral-surgery-the-problem-of-multidrug-resistance
#1
A Kramer, J Pochhammer, P Walger, U Seifert, M Ruhnke, J C Harnoss
In general surgery the etiology of surgical site infections has not significantly changed over the last 30 years. Gram-positive bacteria, e.g. coagulase negative staphylococci (CNS), Staphylococcus aureus and Enterococcus spp. as well as Gram-negative bacteria, e.g. Escherichia coli, Enterobacter spp., Klebsiella spp. and Pseudomonas aeruginosa, are the most common findings. Although in general surgery 10% of the S. aureus causing postoperative wound infections were methicillin resistant (MRSA), no cases of multidrug-resistant Gram-negative (MRGN) bacteria were reported...
February 22, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28221122/worldwide-endemicity-of-a-multidrug-resistant-staphylococcus-capitis-clone-involved-in-neonatal-sepsis
#2
Marine Butin, Patricia Martins-Simões, Jean-Philippe Rasigade, Jean-Charles Picaud, Frédéric Laurent
A multidrug-resistant Staphylococcus capitis clone, NRCS-A, has been isolated from neonatal intensive care units in 17 countries throughout the world. S. capitis NRCS-A prevalence is high in some neonatal intensive care units in France. These data highlight the worldwide endemicity and epidemiologic relevance of this multidrug-resistant, coagulase-negative staphylococci clone.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28210463/frequency-of-inducible-clindamycin-resistance-among-gram-positive-cocci-in-a-tertiary-hospital-tehran-iran
#3
Hiva Saffar, Afsaneh Rajabiani, Alireza Abdollahi, Shirin Habibi, Zohreh Baseri
BACKGROUND AND OBJECTIVES: Accurate designation of antimicrobial susceptibility pattern of the infecting microorganisms is an important crucial factor in making appropriate therapeutic decisions. Macrolide, lincosamide and streptogramin B antibiotics are in a family, reserved as an alternative approach in treatment of resistant Gram positive cocci. Amongst them, clindamycin has been considered as the preferred agent due to its excellent pharmacokinetic properties. The inducible resistance to clindamycin in Gram positive staphylococci and streptococci cannot be recognized by routine broth or agar based susceptibility tests and D-zone testing is necessary...
August 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28203050/normal-flora-of-conjunctiva-and-lid-margin-as-well-as-its-antibiotic-sensitivity-in-patients-undergoing-cataract-surgery-at-phramongkutklao-hospital
#4
Ravee Ratnumnoi, Narumon Keorochana, Chavalit Sontisombat
OBJECTIVE: This study aimed to evaluate the normal flora of conjunctiva and lid margin, as well as its antibiotic sensitivity. DESIGN: This was a prospective cross-sectional study. PATIENTS AND METHODS: A prospective study was conducted on 120 patients who underwent cataract surgery at the Phramongkutklao Hospital from September 2014 to October 2014. Conjunctival and lid margin swabs were obtained from patients before they underwent cataract surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28196391/pentoxifylline-treatment-of-very-low-birth-weight-neonates-with-nosocomial-sepsis
#5
Şahin Hamilçıkan, Emrah Can, Övgü Büke, Meltem Erol, Özlem Bostan Gayret
Objective The objective of this study was to assess the result of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in very low birth weight (VLBW) preterm neonates with nosocomial sepsis. Methods For the 18 VLBW preterm neonates, as an adjunct therapy to antibiotics regimens, pentoxifylline (5 mg/kg/h for 6 hours) was administered to premature infants with sepsis on 3 successive days. Clinical and laboratory parameters were recorded before and after treatment. Results Following pentoxifylline therapy, the immature-to-total neutrophil ratio and C-reactive protein (CRP) levels were significantly decreased, while the blood pH and base excess were significantly increased (p < 0...
February 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28187327/staphylococcal-ecosystem-of-kitoza-a-traditional-malagasy-meat-product
#6
Angela Ratsimba, Sabine Leroy, Jean Paul Chacornac, Danielle Rakoto, Elodie Arnaud, Victor Jeannoda, Régine Talon
Kitoza is a traditional meat product from Madagascar manufactured with strips of pork or beef. The process includes a first step of salting and mixing with spices followed by sun-drying or smoking step. As salting and drying select coagulase-negative staphylococci (CNS), our aim was to identify the CNS species in kitoza with the objective in the future of developing indigenous starters. Microbial analyses revealed that the only pathogenic bacterium enumerated was Staphylococcus aureus, which was found in 54% of the samples...
February 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28182358/aetiology-and-significance-of-hospital-acquired-infections-in-mexico
#7
REVIEW
Nayelli M Alonso-Aguilar, Sara R Juarez-Enriquez, Graciela Castro-Escarpulli, Gildardo Rivera, Virgilio Bocanegra-Garcia, Xianwu Guo, Julieta Luna-Herrera, M G Aguilera-Arreola
Hospital-acquired infections (HAIs) are infections that develop in the hospital environment and can be acquired by a patient or hospital staff. They are complications that combine diverse risk factors that make an individual susceptible and are frequently caused by endogenous and exogenous bacterial agents. The most commonly studied etiological agents are bacteria and fungi, with the former representing the most common etiological agents reported to the Hospital Epidemiological Surveillance Network (RHOVE) between 2007 and 2012...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28181543/meca-related-structure-in-methicillin-resistant-coagulase-negative-staphylococci-from-street-food-in-taiwan
#8
Tsung-Ying Yang, Wei-Wen Hung, Lin Lin, Wei-Chun Hung, Sung-Pin Tseng
Antibiotic-resistant patterns, a mecA homologue complex, and staphylococcal cassette chromosome mec (SCCmec) were analysed in samples of ready-to-eat (RTE) street food in Taiwan. RTE food samples (270) were collected in three densely populated Taiwanese cities between June and November 2014. Among 14 strains being identified as methicillin-resistant coagulase-negative staphylococci (MRCoNS), genetic diversities was determined by PFGE analysis. SCCmec types IV, V, VIII and TXG-24 were detected in 9, and mecASs (a mecA homologue) detected in 8...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178107/late-onset-neonatal-sepsis-a-10-year-review-from-north-queensland-australia
#9
Harsha Gowda, Robert Norton, Andrew White, Yogavijayan Kandasamy
OBJECTIVE: Late-onset sepsis (LOS) in neonates contributes significantly to both morbidity and mortality. To determine the incidence of LOS, risk factors for disease, and the impact on subsequent hospital course, we evaluated a cohort of 6340 neonates admitted to the neonatal intensive care unit and of neonates (3-28 days) admitted from the community between January 2005 and January 2016. METHODS: This was a retrospective case review of all neonates admitted with suspected LOS who had positive blood culture and/or cerebrospinal fluid (CSF) cultures, for an organism determined to be a pathogen...
February 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28173962/prevalence-of-healthcare-associated-infections-in-polish-adult-intensive-care-units-summary-data-from-the-ecdc-european-point-prevalence-survey-of-hospital-associated-infections-and-antimicrobial-use-in-poland-2012-2014
#10
A Deptuła, E Trejnowska, G Dubiel, M Żukowski, A Misiewska-Kaczur, T Ozorowski, W Hryniewicz
BACKGROUND: Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. Local epidemiological studies need to be conducted to set the priorities for surveillance and prevention programmes. AIM: To investigate the epidemiology of hospital-acquired infections (HAIs) among patients admitted to Polish adult ICUs over a three-year period. METHODS: Data were collected according to the European Centre for Disease Prevention and Control (ECDC) European Union Point Prevalence Survey of Healthcare-associated Infections and Antimicrobial Use in European Acute Care Hospitals (EU-PPS HAI & AU) protocol for 39,318 patients within 160 acute care hospitals...
January 4, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28170400/acute-bacterial-meningitis-in-iran-systematic-review-and-meta-analysis
#11
Hamidreza Houri, Ali Pormohammad, Seyed Mohammad Riahi, Mohammad Javad Nasiri, Fatemeh Fallah, Hossein Dabiri, Ramin Pouriran
INTRODUCTION: Bacterial meningitis persists in being a substantial cause of high mortality and severe neurological morbidity, despite the advances in antimicrobial therapy. Accurate data has not been available regarding the epidemiology of bacterial meningitis particularly in developing countries, yet. Indeed, the present systematic review provides a comprehensive data analysis on the prevalence and epidemiology of bacterial meningitis in Iran. METHODS: We systematically reviewed articles from 1994 to 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28164010/epidemiological-and-mortality-trends-in-infective-endocarditis-a-17-year-population-based-prospective-study
#12
Alberto Cresti, Mario Chiavarelli, Marco Scalese, Cesira Nencioni, Silvia Valentini, Francesco Guerrini, Incoronata D'Aiello, Andrea Picchi, Francesco De Sensi, Gilbert Habib
BACKGROUND: The population at risk, the clinical and microbiological features of infective endocarditis (IE) have changed. Aim of our study was to evaluate the contemporary epidemiological trends, over a 17-year period in a definite region of Tuscany, Italy, to analyze the clinical outcomes and associated prognostic factors. METHODS: From 1 January 1998 to 31 December 2014, all patients with a definite diagnosis of IE were prospectively entered in a data-base. The Health-Care system data-base was interrogated to capture patients who could have been missed...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28153968/acute-peritonitis-caused-by-staphylococcus-capitis-in-a-peritoneal-dialysis-patient
#13
Nikolina Basic-Jukic
Acute peritonitis remains the most common complication of peritoneal dialysis (PD), with coagulase-negative staphylococci (CoNS) reported to account for more than 25% of peritonitis episodes (1). Staphylococcus capitis is a gram-positive, catalase-positive CoNS that was originally identified as a commensal on the skin of the human scalp (2). Advancement of microbiological technologies for bacterial identification enables diagnosis of previously unknown causes of acute peritonitis. This is the first reported case of acute peritonitis in a PD patient caused by S...
January 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28153901/draft-genome-sequence-of-staphylococcus-hominis-bhg17-isolated-from-wild-bar-headed-goose-anser-indicus-feces
#14
Wen Wang, Si-Si Zheng, Kirill Sharshov, Hao Sun, Xian-Qiang Wu, Fang Yang, Xue-Lian Wang, Lai-Xing Li
Staphylococcus hominis belongs to a group of coagulase-negative staphylococci and is an opportunistic pathogen, usually found on the skin and mucous membranes. Studies involving S. hominis isolated from wild birds are scarce. Here, we report a 2.365-Mb draft genome sequence of S. hominis BHG17, isolated from the feces of a bar-headed goose.
February 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28151994/toxin-mediates-sepsis-caused-by-methicillin-resistant-staphylococcus-epidermidis
#15
Li Qin, Fei Da, Emilie L Fisher, Daniel C S Tan, Thuan H Nguyen, Chih-Lung Fu, Vee Y Tan, Joshua W McCausland, Daniel E Sturdevant, Hwang-Soo Joo, Shu Y Queck, Gordon Y C Cheung, Michael Otto
Bacterial sepsis is a major killer in hospitalized patients. Coagulase-negative staphylococci (CNS) with the leading species Staphylococcus epidermidis are the most frequent causes of nosocomial sepsis, with most infectious isolates being methicillin-resistant. However, which bacterial factors underlie the pathogenesis of CNS sepsis is unknown. While it has been commonly believed that invariant structures on the surface of CNS trigger sepsis by causing an over-reaction of the immune system, we show here that sepsis caused by methicillin-resistant S...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28140693/pharmacokinetic-drug-evaluation-of-tedizolid-for-the-treatment-of-skin-infections
#16
Darrell McBride, Tamara Krekel, Kevin Hsueh, Michael J Durkin
Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI). Although tedizolid shares many similar properties with linezolid, another oxazolidinone used to treat ABSSSI, the two antibiotics have several key differences. Areas covered: This review provides a detailed summary of the overall pharmacodynamics, pharmacokinetics, clinical efficacy, and safety of tedizolid for the treatment of ABSSSI. Expert opinion: Compared to other antibiotics used for ABSSSI, tedizolid has several advantages...
March 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28137277/antimicrobial-resistance-in-coagulase-negative-staphylococci-from-nigerian-traditional-fermented-foods
#17
P T Fowoyo, S T Ogunbanwo
BACKGROUND: Coagulase-negative staphylococci have become increasingly recognized as the etiological agent of some infections. A significant characteristic of coagulase-negative staphylococci especially strains isolated from animals and clinical samples is their resistance to routinely used antibiotics although, resistant strains isolated from fermented foods have not been fully reported. METHODS: A total of two hundred and fifty-five CoNS isolates were subjected to antimicrobial susceptibility test using the disc diffusion technique...
January 31, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28131956/evaluation-of-the-biofilm-forming-ability-and-its-associated-genes-in-staphylococcus-species-isolates-from-bovine-mastitis-in-argentinean-dairy-farms
#18
Verónica Felipe, Carolina A Morgante, Paola S Somale, Florencia Varroni, María L Zingaretti, Romina A Bachetti, Silvia G Correa, Carina Porporatto
Staphylococcus aureus and coagulase-negative staphylococci (CNS) are important causes of intramammary infection in dairy cattle, and their ability to produce biofilm is considered an important virulence property in the pathogenesis of mastitis. However, the published date on mechanisms and factors involved in infection persistence in the mammary gland remains unclear. The aim of this study was to investigate whether the main Staphylococcus species involved in bovine intramammary infections possess specific characteristics that promote colonization of the udder...
January 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28131570/relationship-between-milk-cathelicidin-abundance-and-microbiologic-culture-in-clinical-mastitis
#19
M F Addis, V Bronzo, G M G Puggioni, C Cacciotto, V Tedde, D Pagnozzi, C Locatelli, A Casula, G Curone, S Uzzau, P Moroni
The availability of reliable tools to enable the sensitive and specific detection of mastitis in dairy cows can assist in developing control strategies and promote the more rational use of antibiotics. We have developed a milk cathelicidin ELISA that shows high sensitivity and specificity for dairy cow mastitis, based on latent class analysis. In this study, we investigated the effect of microbial agents on cathelicidin abundance in the milk of cows with clinical mastitis. We subjected 535 quarter milk samples (435 from quarters showing signs of clinical mastitis and 100 from healthy quarters as a control) to milk cathelicidin ELISA, somatic cell count (SCC), and microbiologic culture...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28129822/-antimicrobial-spectrum-of-dalbavancin-mechanism-of-action-and-in-vitro-activity-against-gram-positive-microorganisms
#20
Emilia Cercenado
Because of the increase in bacterial resistance, there is a need for new antimicrobial agents. Dalbavancin is a semisynthetic glycopeptide that inhibits the late stages of bacterial cell wall synthesis in the same way as vancomycin, but in addition, its lipophilic side chain anchors dalbavancin to the cellular membrane and allows enhanced activity compared with that of vancomycin. Dalbavancin possesses a broad spectrum of in vitro activity against Gram-positive aerobic and anaerobic microorganisms, being 4-8 times more potent than vancomycin...
January 2017: Enfermedades Infecciosas y Microbiología Clínica
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