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https://www.readbyqxmd.com/read/28343184/regulatory-role-of-ngfs-in-neurocognitive-functions
#1
Ashutosh Kumar, Vikas Pareek, Muneeb A Faiq, Pavan Kumar, Khursheed Raza, Pranav Prasoon, Subrahamanyam Dantham, Sankat Mochan
Nerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain...
March 27, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28343070/the-activation-of-akt-mtor-pathway-by-bleomycin-in-epithelial-to-mesenchymal-transition-of-human-submandibular-gland-cells-a-treatment-mechanism-of-bleomycin-for-mucoceles-of-the-salivary-glands
#2
Yu Cai, Rui Sun, Rong Wang, Jian-Gang Ren, Wei Zhang, Yi-Fang Zhao, Ji-Hong Zhao
OBJECTIVE: Bleomycin (BLM) has been found safe and highly effective in the treatment of the mucoceles by intralesional injection in our previous study. The present research was designed to investigate whether epithelial-to-mesenchymal transition (EMT) contributes to the therapeutic effects of BLM for mucoceles of the salivary glands. MATERIAL AND METHODS: The cell proliferation and apoptosis of human submandibular gland cells (HSG cells) were examined by Cell Counting Kit-8 assay and Annexin V binding assay respectively...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28342995/mechanisms-of-metal-sorption-by-biochars-biochar-characteristics-and-modifications
#3
REVIEW
Hongbo Li, Xiaoling Dong, Evandro B da Silva, Letuzia M de Oliveira, Yanshan Chen, Lena Q Ma
Biochar produced by thermal decomposition of biomass under oxygen-limited conditions has received increasing attention as a cost-effective sorbent to treat metal-contaminated waters. However, there is a lack of information on the roles of different sorption mechanisms for different metals and recent development of biochar modification to enhance metal sorption capacity, which is critical for biochar field application. This review summarizes the characteristics of biochar (e.g., surface area, porosity, pH, surface charge, functional groups, and mineral components) and main mechanisms governing sorption of As, Cr, Cd, Pb, and Hg by biochar...
March 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/28342981/mechanisms-of-in-vivo-release-of-triamcinolone-acetonide-from-plga-microspheres
#4
Amy C Doty, David G Weinstein, Keiji Hirota, Karl F Olsen, Rose Ackermann, Yan Wang, Stephanie Choi, Steven P Schwendeman
Little is known about the underlying effects controlling in vitro-in vivo correlations (IVIVCs) for biodegradable controlled release microspheres. Most reports of IVIVCs that exist are empirical in nature, typically based on a mathematical relationship between in vitro and in vivo drug release, with the latter often estimated by deconvolution of pharmacokinetic data. In order to improve the ability of in vitro release tests to predict microsphere behavior in vivo and develop more meaningful IVIVCs, the in vivo release mechanisms need to be characterized...
March 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28342835/lipids-in-exosomes-current-knowledge-and-the-way-forward
#5
REVIEW
Tore Skotland, Kirsten Sandvig, Alicia Llorente
Lipids are essential components of exosomal membranes, and it is well-known that specific lipids are enriched in exosomes compared to their parent cells. In this review we discuss current knowledge about the lipid composition of exosomes. We compare published data for different lipid classes in exosomes, and what is known about their lipid species, i.e. lipid molecules with different fatty acyl groups. Moreover, we elaborate on the hypothesis about hand-shaking between the very-long-chain sphingolipids in the outer leaflet and PS 18:0/18:1 in the inner leaflet, and we propose this to be an important mechanism in membrane biology, not only for exosomes...
March 23, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28342769/a-laboratory-study-on-attentional-bias-as-an-underlying-mechanism-affecting-the-link-between-cortisol-and-performance-leading-to-a-discussion-on-the-nature-of-the-stressor-artificial-vs-psychosocial
#6
Franziska Lautenbach
Although cortisol is assumed to influence performance by affecting cognition during stressful and competitive situations, to date this assumption has not been tested empirically. Therefore, the aim of this study was to investigate whether the influence of cortisol on performance is mediated by attentional processing of emotional information. Forty-six male golfers were tested in a mixed design. The cold pressor task (CPT) was used to artificially increase cortisol levels in the experimental group relative to the control group, who had to put their forearm in warm water...
March 22, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28342734/integration-of-microbiome-and-epigenome-to-decipher-the-pathogenesis-of-autoimmune-diseases
#7
REVIEW
Beidi Chen, Luxi Sun, Xuan Zhang
The interaction between genetic predisposition and environmental factors are of great significance in the pathogenesis and development of autoimmune diseases (AIDs). The human mucosa is the most frequent site that interacts with the exterior environment, and commensal microbiota at the gut and other human mucosal cavities play a crucial role in the regulation of immune system. Growing evidence has shown that the compositional and functional changes of mucosal microbiota are closely related to AIDs. Gut dysbiosis not only influence the expression level of Toll-like receptors (TLRs) of antigen presenting cells, but also contribute to Th17/Treg imbalance...
March 22, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28342723/effects-of-eccentric-overload-training-on-patellar-tendon-and-vastus-lateralis-in-three-days-of-consecutive-running
#8
Fernando Sanz-López, César Berzosa, Fidel Hita-Contreras, Antonio Martínez-Amat
BACKGROUND: The analysis of structural changes in patellar tendon and muscle of healthy subjects in response to mechanical loads provides useful insight into the mechanism underlying overuse injuries. METHODS: Changes produced in tendon and muscles structures after eccentric overload training and three consecutive running days were examined. Twenty healthy subjects were recruited and divided into two groups. One group (ECC) performed eccentric overload squat training (six weeks)...
March 22, 2017: Knee
https://www.readbyqxmd.com/read/28342657/targeting-bap1-a-new-paradigm-for-mesothelioma
#9
EDITORIAL
L M Schunselaar, W Zwart, P Baas
New treatment strategies for malignant pleural mesothelioma (MPM) are important. BAP1 mutations are present in 47-67% of the MPM tumors, making this a good target for treatment. Multiple functions of BAP1 are investigated in the preclinical situation. Due to many functions of BAP1, the phenotypic effect of BAP1 is diverse. Preclinical data on inhibitors reversing these phenotypic effects are promising. However, the mechanism of BAP1 is not fully elucidated yet and further research about the mechanism and possible inhibitors is necessary...
March 18, 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28342618/a-realist-synthesis-of-social-connectivity-interventions-during-transition-to-parenthood-the-value-of-relationships
#10
Claudine T Bennett, Judy L Buchan, Nicole Letourneau, Stuart G Shanker, Anne Fenwick, Brenda Smith-Chant, Cyndi Gilmer
BACKGROUND: Social connections are important during the transition to parenthood. A wide body of literature suggests that these connections enhance health and contribute to wellbeing. In the case of parents and families, social connections can influence child development. Nurses and public health agencies are in a unique position to advocate for resources and approaches to enhance social connectivity for parents during this important life transition. OBJECTIVES: The aim of this review was to identify the universal social connectivity interventions that work, and the conditions that foster social connections for parents and enhance child development...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342352/mechanochemical-mechanism-of-rapid-dechlorination-of-hexachlorobenzene
#11
Shanshan Deng, Shaoguo Kang, Nannan Feng, Jianxin Zhu, Bo Yu, Xiaofeng Xie, Jing Chen
Recent researches indicate that mechanochemical treatment (MCT) is a promising method to degrade the environmental hazards, especially in the area of persistent organic pollutants (POPs) disposal. However, the mechanochemical dechlorination mechanism of POPs still needs to be further verified. In this mechanochemical process, hexachlorobenzene (HCB) was chosen as a model pollutant with aluminum and alumina (Al+Al2O3) powders as the co-milling regents. Both of the intermediate analysis and quantum chemical calculations were adopted to elucidate the free radical dechlorination mechanism of HCB...
March 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340459/transcriptional-profiling-of-porcine-granulosa-cells-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin
#12
Agnieszka Sadowska, Anna Nynca, Monika Ruszkowska, Lukasz Paukszto, Kamil Myszczynski, Karina Orlowska, Sylwia Swigonska, Tomasz Molcan, Jan P Jastrzebski, Renata E Ciereszko
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment. An exposure of living organisms to TCDD may result in numerous disorders, including reproductive pathologies. The aim of the current study was to examine the effects of TCDD on the transcriptome of porcine granulosa cell line AVG-16. By employing next-generation sequencing (NGS) we aimed to identify genes potentially involved in the mechanism of TCDD action and toxicity in porcine granulosa cells...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340387/an-exploration-of-the-effect-and-interaction-mechanism-of-bisphenol-a-on-waste-sludge-hydrolysis-with-multi-spectra-isothermal-titration-microcalorimetry-and-molecule-docking
#13
Guangying Hou, Rui Zhang, Xiaoyan Hao, Chunguang Liu
An increasing amount of bisphenol A (BPA) is being produced and used, then discharged into sewage treatment plants and accumulated in sludge or soil, when the sludge is used as fertilizer. Accumulation of BPA in sludge or soil causes poisoning to the enzyme, which affects the biological treatment of sludge and the circulation and conversion of materials in soil. In this research, effect of BPA on sludge hydrolysis is studied from the respect of concentration and components of soluble organic matter in sludge, using three-dimensional fluorescence spectra...
March 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340378/current-fda-approved-treatments-for-non-small-cell-lung-cancer-and-potential-biomarkers-for-its-detection
#14
REVIEW
Karla A Ruiz-Ceja, Yolanda I Chirino
BACKGROUND: Lung cancer is the leading worldwide cancer with almost 1.5 million deaths every year. Some drugs for lung cancer treatment have been available on the market for decades, but novel drugs have emerged promising better outcomes, especially for Non-Small Cell Lung Cancer (NSCLC), which represents 75% of lung cancer cases. However, how much do drugs have evolved for NSCLC treatment? Are they sharing the same mechanism of action? AIM: In this review we analyzed how the approved drugs by Federal Drug Agency for NSCLC have advanced in the last four decades identifying shared mechanism of action of medicines against NSCLC treatment and some of the potential biomarkers for early detection...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340239/hypertension-in-dialysis-patients-a-consensus-document-by-the-european-renal-and-cardiovascular-medicine-eureca-m-working-group-of-the-european-renal-association-european-dialysis-and-transplant-association-era-edta-and-the-hypertension-and-the-kidney-working
#15
Pantelis A Sarafidis, Alexandre Persu, Rajiv Agarwal, Michel Burnier, Peter de Leeuw, Charles J Ferro, Jean-Michel Halimi, Gunnar H Heine, Michel Jadoul, Faical Jarraya, Mehmet Kanbay, Francesca Mallamaci, Patrick B Mark, Alberto Ortiz, Gianfranco Parati, Roberto Pontremoli, Patrick Rossignol, Luis Ruilope, Patricia Van der Niepen, Raymond Vanholder, Marianne C Verhaar, Andrzej Wiecek, Gregoire Wuerzner, Gérard M London, Carmine Zoccali
In patients with end-stage renal disease (ESRD) treated with haemodialysis or peritoneal dialysis, hypertension is common and often poorly controlled. Blood pressure (BP) recordings obtained before or after haemodialysis display a J- or U-shaped association with cardiovascular events and survival, but this most likely reflects the low accuracy of these measurements and the peculiar haemodynamic setting related to dialysis treatment. Elevated BP detected by home or ambulatory BP monitoring is clearly associated with shorter survival...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28340181/different-expression-patterns-of-sperm-motility-related-genes-in-testis-of-diploid-and-tetraploid-cyprinid-fish1
#16
Fangzhou Hu, Kang Xu, Yunfan Zhou, Chang Wu, Shi Wang, Jun Xiao, Min Wen, Rurong Zhao, Kaikun Luo, Min Tao, Wei Duan, Shaojun Liu
Sperm motility is an important standard to measure the fertility of male. In our previous study, we found that the diploid spermatozoa from allotetraploid hybrid (4nAT) had longer durations of rapid and slow progressive motility than haploid spermatozoa from common carp (COC). In this study, to explore sperm motility-related molecular mechanisms, we compared the testis tissues transcriptomes from two years old male COC and 4nAT. The RNA-seq data revealed that 2985 genes were differentially expressed between COC and 4nAT, including 2216 up-regulated and 769 down-regulated genes in 4nAT...
March 7, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28340126/association-between-socioeconomic-status-and-access-to-care-and-quitting-smoking-with-and-without-assistance
#17
Sarah A Edwards, Russell C Callaghan, Robert E Mann, Susan J Bondy
Introduction: Socio-economic disparities in smoking rates persist, in Ontario, despite public health care and universal tobacco control policies. Mechanisms for continuing disparities are not fully understood. Unequal access or utilization of assistance for cessation may contribute. The objective of this research was to use longitudinal data on smokers to examine the associations between socioeconomic status (SES) and access to care measures and assisted and unassisted quit attempts. Methods: Data were taken from 3578 smokers with at least one follow-up interview participating in the Ontario Tobacco Survey (OTS)...
March 10, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28340087/nutrigenomic-point-of-view-on-effects-and-mechanisms-of-action-of-ruminant-trans-fatty-acids-on-insulin-resistance-and-type-2-diabetes
#18
Bénédicte L Tremblay, Iwona Rudkowska
Evidence from observational studies suggests beneficial effects of ruminant trans fatty acids (rTFA) on insulin resistance (IR) and type 2 diabetes (T2D). However, beneficial effects of rTFA are not always observed in cell, animal, and human studies. This narrative review presents potential mechanisms of action of rTFA using nutrigenomics and microRNA results in an integrative model. In addition, the review presents factors, including measures of IR and T2D, dose and duration of studies, as well as health status, ethnicity, and genotypes of subjects, that may help explain the heterogeneity in response to rTFA supplementation...
March 7, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28339828/single-session-of-functional-electrical-stimulation-assisted-walking-produces-corticomotor-symmetry-changes-related-to-changes-in-poststroke-walking-mechanics
#19
Jacqueline A Palmer, HaoYuan Hsiao, Tamara Wright, Stuart A Binder-Macleod
Background: Recent research demonstrated that symmetry of corticomotor drive to paretic and nonparetic plantarflexor muscles are related to the biomechanical ankle moment strategy that individuals with chronic stroke used to achieve their greatest walking speeds. Rehabilitation strategies that promote corticomotor balance could potentially improve post-stroke walking mechanics and enhance functional ambulation. Objective: To 1) test the effectiveness of a single session of gait training using functional electrical stimulation (FES) to improve plantarflexor corticomotor symmetry and plantarflexion ankle moment symmetry and 2) determine if changes in corticomotor symmetry relate to changes in ankle moment symmetry within the session...
February 23, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28339638/the-impact-of-older-parents-pain-symptoms-on-adult-children
#20
Karl Pillemer, Catherine Riffin, J Jill Suitor, Siyun Peng, M C Reid
Objective. : Not only is persistent pain a debilitating health problem for older adults, it also may have negative effects on family relationships. Studies have documented the effects of pain on spouses and on parents of young children. However, research has not extended this line of inquiry to later life, and specifically to the impact of older parents' pain symptoms on adult children. This study addresses the question: Does older mothers' pain affect the quality of relations with offspring? Subjects and Design...
February 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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