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https://www.readbyqxmd.com/read/29166713/-advances-in-the-research-of-molecular-mechanism-of-negative-pressure-wound-therapy-in-improving-wound-healing
#1
Y Liu, D H Hu
Recently, negative pressure wound therapy (NPWT) is a rising technology to improve wound healing. In clinical application, it benefits fast debridement and wound close, limits infection, and promotes wound healing. It is an effective therapy for all kinds of acute or chronic wound. Currently, researches demonstrate that NPWT promotes angiogenesis, granulation tissue growth, and extracellular matrix remodeling through regulating the signaling of anti-inflammatory cytokines, mechanicalreceptor and chemoreceptor, which is related to several growth factors and inflammatory factors...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#2
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29166619/extensive-homeostatic-t-cell-phenotypic-variation-within-the-collaborative-cross
#3
Jessica B Graham, Jessica L Swarts, Michael Mooney, Gabrielle Choonoo, Sophia Jeng, Darla R Miller, Martin T Ferris, Shannon McWeeney, Jennifer M Lund
The Collaborative Cross (CC) is a panel of reproducible recombinant inbred mouse strains with high levels of standing genetic variation, affording an unprecedented opportunity to perform experiments in a small animal model containing controlled genetic diversity while allowing for genetic replicates. Here, we advance the utility of this unique mouse resource for immunology research because it allows for both examination and genetic dissection of mechanisms behind adaptive immune states in mice with distinct and defined genetic makeups...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166412/mir-195-inhibits-macrophages-pro-inflammatory-profile-and-impacts-the-crosstalk-with-smooth-muscle-cells
#4
Joao Paulo Bras, Andreia Machado Silva, George A Calin, Mario Adolfo Barbosa, Susana Gomes Santos, Maria Ines Almeida
Macrophages are a main component of atherosclerotic plaques. Recent studies suggest that pro-inflammatory M1 macrophages are pro-atherogenic while M2 macrophages promote plaque stability. Moreover, toll-like receptor signalling pathways are implicated in atherosclerotic plaque formation, evolution and regression. We propose microRNAs as key regulators of these processes. In this context, our goal is to promote inflammation resolution using miR-195 to reduce M1-like macrophage polarization and to evaluate the molecular mechanisms underlying such effect, as well as to explore the functional consequences for smooth muscle cell recruitment...
2017: PloS One
https://www.readbyqxmd.com/read/29166377/the-effect-of-body-position-on-esophageal-reflexes-in-cats-a-possible-mechanism-of-sids
#5
Ivan M Lang, Bidyut K Medda, Reza Shaker, Sudarshan Jadcherla
BACKGROUND: It has been hypothesized that life threatening events are caused by supra-esophageal reflux (SER) of gastric contents which activates laryngeal chemoreflex-stimulated apnea. Placing infants supine decreases the risk of sudden infant death syndrome (SIDS). The aim of this study was to determine whether body position affects esophageal reflexes that control SER. METHODS: We instrumented the pharyngeal and esophageal muscles of decerebrate cats (N=14) to record EMG or manometry, and investigated the effects of body position on the esophago-upper esophageal sphincter (UES) contractile reflex (EUCR), esophago-UES relaxation reflex (EURR), esophagus-stimulated pharyngeal swallow response (EPSR), secondary peristalsis (SP), and pharyngeal swallow (PS)...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29166248/neighborhood-disadvantage-and-allostatic-load-in-african-american-women-at-risk-for-obesity-related-diseases
#6
Marissa Tan, Abdullah Mamun, Heather Kitzman, Surendra Reddy Mandapati, Leilani Dodgen
INTRODUCTION: African American women have higher rates of obesity and related chronic disease than other demographic groups. The poorer health of African American women compared with other groups may be explained by allostatic load, or cumulative physiologic stress, due to chronic socioeconomic disadvantage. The objective of this study was to evaluate neighborhood and individual factors contributing to allostatic load in African American women at risk for obesity-related diseases. METHODS: This study evaluated the relationship of allostatic load with neighborhood disadvantage, individual socioeconomic determinants, and synergism between neighborhood and socioeconomic disadvantage, along with health behaviors and other factors as mediators in African American women...
November 22, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29165921/impact-of-flue-gas-compounds-on-microalgae-and-mechanisms-for-carbon-assimilation-and-utilization-a-review
#7
Arun Krishna Vuppaladadiyam, Joseph G Yao, Nicholas Florin, Anthe George, Xiaoxiong Wang, Leen Labeeuw, Yuelu Jiang, Ryan W Davis, Ali Abbas, Peter Ralph, Paul S Fennell, Ming Zhao
In order to shift the world to a more sustainable future, it is necessary to phase out the use of fossil fuels and focus on the development of low-carbon alternatives. However, this transition is slow so there still exists a large dependence on fossil-derived power and therefore CO2 release. Owing to the potential for assimilating and utilizing CO2 to generate carbon neutral products such as biodiesel, the application of microalgae technology to capture CO2 from flue gases has gained significant attention over the past decade...
November 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29165906/noninvasive-high-speed-near-infrared-imaging-of-the-biomolecular-distribution-and-molecular-mechanism-of-embryonic-development-in-fertilized-fish-eggs
#8
Mika Ishigaki, Takashi Nishii, Paralee Puangchit, Yui Yasui, Christian W Huck, Yukihiro Ozaki
In the present study, the distribution of biomaterials and its molecular mechanism of embryonic development in Japanese medaka fish were analyzed nondestructively and noninvasively without staining using near-infrared (NIR) imaging. The microscope NIR imaging system used in this research was a device capable of ultra-high-speed imaging; using this system, one can acquire microscopic imaging data in a few seconds. Therefore, the medaka eggs remained alive throughout measurements and were successfully monitored in vivo...
November 22, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29165645/down-regulation-of-mir-378a-3p-induces-decidual-cell-apoptosis-a-possible-mechanism-for-early-pregnancy-loss
#9
Lihua Hong, Tiantian Yu, Haiyan Xu, Ningning Hou, Qi Cheng, Lihua Lai, Qingqing Wang, Jianzhong Sheng, Hefeng Huang
STUDY QUESTION: Do microRNAs (miRNAs) contribute to human early pregnancy loss (EPL)? SUMMARY ANSWER: miR-378a-3p expression is regulated by progesterone and is down-regulated in ducidua of EPL patients which may contribute to decidual apoptosis through Caspase-3 activation. WHAT IS KNOWN ALREADY: A variety of miRNAs have been demonstrated to be associated with the development of decidualization and placental formation. However, little has been reported on the roles of miRNA in the pathogenesis of EPL...
November 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29165572/principled-approaches-to-missing-data-in-epidemiologic-studies
#10
Neil J Perkins, Stephen R Cole, Ofer Harel, Eric J Tchetgen Tchetgen, BaoLuo Sun, Emily M Mitchell, Enrique F Schisterman
Principled methods to appropriately analyze missing data have long existed; however, broad implementation of these methods remains challenging. In this and companion papers, we discuss issues of missing data in the epidemiologic literature. We provide details regarding missing data mechanisms and nomenclature and motivate principled analyses through a detailed comparison of multiple imputation and inverse probability weighting. We do so in the setting of a masked data-analytic challenge with missing data induced by known mechanisms to data from the Collaborative Perinatal Project, a multisite US study conducted from 1959 to 1974...
November 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29165557/inverse-probability-weighted-estimation-for-monotone-and-nonmonotone-missing-data
#11
BaoLuo Sun, Neil J Perkins, Stephen R Cole, Ofer Harel, Emily Mitchell, Enrique F Schisterman, Eric J Tchetgen Tchetgen
Missing data is of common occurrence in epidemiologic research. In this paper, three data sets with induced missing values from the Collaborative Perinatal Project, a multisite United States study conducted from 1959 to 1974, are provided as examples of prototypical epidemiologic studies with missing data. Our goal is to estimate the effect of maternal smoking behavior on spontaneous abortion while adjusting for numerous confounders. At the same time, we do not necessarily wish to evaluate the joint distribution among potentially unobserved covariates, which is seldom the subject of substantive scientific interest...
November 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29165451/optical-magnetic-bifunctional-properties-and-mechanistic-insights-on-upconversion-of-nayf4-yb-ho-tm-nagdf4-with-a-tunable-nanodumbbell-morphology
#12
Zhichao Yu, Haifeng Zhou, Guangjun Zhou, Juan Zhou, Yaqiang Wu, Xingshuang Zhang, Tao Wang, Dapeng Huang, Xinqiang Wang, Jifan Hu
The energy-upconversion of lanthanide-doped nanoparticles with a core-shell structure can be utilized to enhance and tune optical properties and can generate multifunctionality in a single system. Herein, the core-shell nanoparticles NaYF4:Yb,Ho,Tm@NaGdF4 were prepared by thermally decomposing lanthanide acetylacetonate precursors. Through modifying the molar ratio of the core and shell, nanodumbbell-shaped particles with different sizes and morphologies were precisely synthesized. The formation mechanism and the heterogeneous epitaxial growth process of the nanodumbbell-shaped particles were studied...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29165444/low-temperature-crystallization-of-solution-derived-metal-oxide-thin-films-assisted-by-chemical-processes
#13
Iñigo Bretos, Ricardo Jiménez, Jesús Ricote, M Lourdes Calzada
Over the last few years the efforts devoted to the research on low-temperature processing of metal oxide thin films have increased notably. This has enabled the direct integration of metal oxide layers (amorphous semiconductors) on low-melting-point polymeric substrates for flexible electronic systems, which adds to the economic and environmental benefits of the use of these processes with reduced energy consumption. More challenging is the preparation of crystalline complex oxide films at temperatures compatible with their direct integration in flexible devices...
November 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29165349/combating-fusarium-infection-using-bacillus-based-antimicrobials
#14
REVIEW
Noor Khan, Maskit Maymon, Ann M Hirsch
Despite efforts to control toxigenic Fusarium species, wilt and head-blight infections are destructive and economically damaging diseases that have global effects. The utilization of biological control agents in disease management programs has provided an effective, safe, and sustainable means to control Fusarium-induced plant diseases. Among the most widely used microbes for biocontrol agents are members of the genus Bacillus. These species influence plant and fungal pathogen interactions by a number of mechanisms such as competing for essential nutrients, antagonizing pathogens by producing fungitoxic metabolites, or inducing systemic resistance in plants...
November 22, 2017: Microorganisms
https://www.readbyqxmd.com/read/29164988/development-of-peritoneal-carcinomatosis-in-epithelial-ovarian-cancer-a-review
#15
Juliette O A M van Baal, Cornelis J F van Noorden, Rienk Nieuwland, Koen K Van de Vijver, Auguste Sturk, Willemien J van Driel, Gemma G Kenter, Christianne A R Lok
Epithelial ovarian cancer (EOC) metastasizes intra-abdominally with often numerous, superficial, small-sized lesions. This so-called peritoneal carcinomatosis is difficult to treat, and peritoneal recurrences are frequently observed, leading to a poor prognosis. Underlying mechanisms of interactions between EOC and peritoneal cells are incompletely understood. This review summarizes and discusses the development of peritoneal carcinomatosis from a cell-biological perspective, focusing on characteristics of EOC and peritoneal cells...
November 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29164825/autism-spectrum-disorder-and-birth-spacing-findings-from-the-study-to-explore-early-development-seed
#16
Laura A Schieve, Lin H Tian, Carolyn Drews-Botsch, Gayle C Windham, Craig Newschaffer, Julie L Daniels, Li-Ching Lee, Lisa A Croen, M Danielle Fallin
Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non-ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter-pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi-site case-control study with rigorous case-finding and case-classification methods and detailed data collection on maternal reproductive history...
November 22, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29164815/application-of-kartogenin-for-musculoskeletal-regeneration
#17
REVIEW
Gun-Il Im
Kartogenin (KGN) is a recently characterized small molecule that promotes the selective differentiation of mesenchymal stem cells into chondrocytes, and thus, KGN stimulates cartilage regeneration. KGN also possess chondro-protective effect. Furthermore, because it is highly stable small molecule, KGN can be stored and transported at room temperature. These obvious superiorities over peptide growth factors make KGN a desirable chondrogenic agent for cartilage regeneration. Since its discovery, KGN has drawn much attention as a new chondrogenic drug for intraarticular (IA) treatment...
November 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29164804/biomaterials-and-advanced-technologies-for-hemostatic-management-of-bleeding
#18
REVIEW
DaShawn A Hickman, Christa L Pawlowski, Ujjal D S Sekhon, Joyann Marks, Anirban Sen Gupta
Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders...
November 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29164716/mechanism-matters-the-cause-of-fluctuations-in-boom-bust-populations-governs-optimal-habitat-restoration-strategy
#19
Gina K Himes Boor, Cheryl B Schultz, Elizabeth E Crone, William F Morris
Many populations exhibit boom-bust dynamics in which abundance fluctuates dramatically over time. Past research has focused on identifying whether the cause of fluctuations is primarily exogenous, e.g., environmental stochasticity coupled with weak density dependence, or endogenous, e.g., over-compensatory density dependence. Far fewer studies have addressed whether the mechanism responsible for boom-bust dynamics matters with respect to at-risk species management. Here, we ask whether the best strategy for restoring habitat across a landscape differs under exogenously versus endogenously driven boom-bust dynamics...
November 21, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29164610/shared-pathological-pathways-of-alzheimer-s-disease-with-specific-comorbidities-current-perspectives-and-interventions
#20
REVIEW
Christiane M Nday, Despoina Eleftheriadou, Graham Jackson
Alzheimer's disease (AD) belongs to one of the most multifactorial, complex and heterogeneous morbidity-leading disorders. Despite the extensive research in the field, AD pathogenesis is still at some extend obscure. Mechanisms linking AD with certain comorbidities, namely diabetes mellitus, obesity and dyslipidemia, are increasingly gaining importance, mainly due to their potential role in promoting AD development and exacerbation. Their exact cognitive impairment trajectories, however, remain to be fully elucidated...
November 21, 2017: Journal of Neurochemistry
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