Yi Yang, Zhenyu Xiao, Weijie Yang, Yangyang Sun, Xin Sui, Xueyang Lin, Xinyi Yang, Zhenghao Bao, Ziqi Cui, Yingkai Ma, Weidong Li, Shengran Wang, Jun Yang, Yongan Wang, Yuan Luo
Idiopathic pulmonary fibrosis (IPF) poses significant challenges due to limited treatment options despite its complex pathogenesis involving cellular and molecular mechanisms. This study investigated the role of transient receptor potential ankyrin 1 (TRPA1) channels in regulating M2 macrophage polarization in IPF progression, potentially offering novel therapeutic targets. Using a bleomycin-induced pulmonary fibrosis model in C57BL/6J mice, we assessed the therapeutic potential of the TRPA1 inhibitor HC-030031...
April 18, 2024: Cellular and Molecular Life Sciences: CMLS