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https://www.readbyqxmd.com/read/29748608/hepatic-steatosis-associated-with-decreased-%C3%AE-oxidation-and-mitochondrial-function-contributes-to-cell-damage-in-obese-mice-after-thermal-injury
#1
Li Diao, Christopher Auger, Hisato Konoeda, Ali-Reza Sadri, Saeid Amini-Nik, Marc G Jeschke
Severely burned patients who are morbidly obese have poor clinical outcomes with aggravated metabolic consequences, a higher incidence of multiple organ dysfunction/failure, and significantly increased morbidity and mortality. The underlying mechanisms of these adverse outcomes are essentially unknown. Since the liver is one of the central metabolic organs, we hypothesized that thermal injury in obese patients leads to substantially increased lipolysis, hepatic fat infiltration, resulting in profound hepatic cellular and organellar alterations, consequently causing liver damage and severely augmented metabolic dysfunction...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29696063/the-response-of-intercellular-adhesion-molecule-1-to-exhaustive-submaximal-exercise-and-its-correlation-with-physiological-and-anthropometric-measures
#2
Hossein Taheri Chadorneshin, Ali Golestani, Fatemeh Jamali, Sakineh Mokhtari Motameni Shirvan, Hadi Sarir, Seyed Hosein Abtahi Eivary
Introduction: Intercellular adhesion molecule-1 (ICAM-1) acts as the main factor in the occurrence of atherosclerosis and inflammatory diseases. This study aimed to investigate the response of ICAM-1to exhaustive submaximal exercise and its correlation with maximal oxygen consumption (VO2max), body mass index (BMI), waist-hip ratio (WHR), body fat percentage (BF %) and calories burned during exercise (CB) in healthy men. Materials and methods: Thirteen healthy men (mean ± standard deviation: age 23 ± 3 years, weight 78 ± 4 kg, height 180 ± 4 cm) cooperated in this quasi-experimental study and performed a single bout of exhaustive submaximal exercise on a cycle ergometer...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29684791/the-role-of-promyelocytic-leukemia-protein-in-steatosis-associated-hepatic-tumors-related-to-chronic-hepatitis-b-virus-infection
#3
Yih-Lin Chung, Mei-Ling Wu
The persistence of hepatitis B surface antigen (HBsAg) is a risk factor for the development of steatosis-associated tumors in chronic hepatitis B virus (HBV) infection, yet little is known about the metabolic link with this factor. We correlated HBV-related pathogenesis in genetically engineered mice and human carriers with metabolic proteomics and lipogenic gene expression profiles. The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis)...
April 20, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29684639/use-of-autologous-fat-graft-and-fractiononal-co-2-laser-to-optimize-the-aesthetic-and-functional-results-in-patients-with-severe-burn-outcomes-of-the-face
#4
Simone La Padula, Barbara Hersant, Jean Paul Meningaud, Francesco D'Andrea
BACKGROUND: Facial burn outcomes are often difficult to treat. Residual scars represent a problem for aesthetic and functional concerns as well as for patient's social and psychological life. Autologous fat graft can be used in the treatment of burn outcomes, providing a sensitive improvement in the quality of the burned areas. The aim of our report is the discussion of the value of lipofilling and fractional CO2 laser in optimizing aesthetic and functional results of burn sequelae. METHODS: We treated twenty four patients with post burns scars who underwent to autologous fat graft followed by CO2 fractional laser treatment...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678548/acetyl-l-carnitine-is-an-anti-angiogenic-agent-targeting-the-vegfr2-and-cxcr4-pathways
#5
Denisa Baci, Antonino Bruno, Barbara Bassani, Matilde Tramacere, Lorenzo Mortara, Adriana Albini, Douglas M Noonan
Carnitines play an important role in the energy exchange in cells, involved in the transport of fatty acids across the inner mitochondrial membrane. L-Acetylcarnitine (ALCAR) is an acetic acid ester of carnitine that has higher bioavailability than carnitine and is considered a fat-burning energizer supplement. We previously found that in serum samples from prostate cancer (PCa) patients, 3 carnitine family members were significantly decreased, suggesting a potential protective role of carnitine against PCa...
April 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29673543/dihydrocapsiate-supplementation-prevented-high-fat-diet-induced-adiposity-hepatic-steatosis-glucose-intolerance-and-gut-morphological-alterations-in-mice
#6
Ritesh K Baboota, Pragyanshu Khare, Priyanka Mangal, Dhirendra Pratap Singh, Kamlesh K Bhutani, Kanthi K Kondepudi, Jaspreet Kaur, Mahendra Bishnoi
Despite the lipolytic and thermogenic properties of capsaicin, its putative use as a weight-lowering dietary supplement has been limited because of the burning sensation caused by capsaicin when it comes in contact with mucous membranes. A potential alternative to capsaicin are the capsinoids, nonpungent capsaicin analogs that exhibit effects similar to capsaicin. Whereas the antiobesity properties of capsinoids have been reported, the effectiveness of FDA-approved synthetic dihydrocapsiate has not yet been investigated...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29649104/coordination-of-gpr40-and-ketogenesis-signaling-by-medium-chain-fatty-acids-regulates-beta-cell-function
#7
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E Mitchell, El Hadji M Dioum
Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory factors in the development and progression of the disease. Unlike long chain triglycerides, medium chain triglycerides (MCT) increase fat burning in animal and human subjects as well as serum C-peptide in type 2 diabetes patients. We evaluated the beneficial effects of MCT on β-cells in vivo and in vitro. MCT improved glycemia in aged rats via β-cell function assessed by measuring insulin secretion and content...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29642370/global-transcriptome-analysis-of-brown-adipose-tissue-of-diet-induced-obese-mice
#8
Jingyi Cao, Qi Zhu, Lin Liu, Bradley J Glazier, Benjamin C Hinkel, Chun Liang, Haifei Shi
Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease resulting from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) has thermogenic capacity that burns calories to produce heat, and it is a potential target for the treatment and prevention of obesity. There is limited information regarding the impact of HFD on the BAT transcriptome. We hypothesized that HFD-induced obesity would lead to transcriptional regulation of BAT genes. RNA sequencing was used to generate global transcriptome profiles from BAT of lean mice fed with a low-fat diet (LFD) and obese mice fed with a HFD...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29609280/-advances-in-the-research-of-relationship-between-brown-or-beige-fat-and-hypermetabolism-after-severe-burn
#9
M Zhang, Y Liu, X Zhang
Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Brown or beige adipose tissue could be regulated by stress hormones and some cytokines which increase and persist in high level for several months after severe burn...
March 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29596612/burn-injury-may-have-age-dependent-effects-on-strength-and-aerobic-exercise-capacity-in-males
#10
Eric Rivas, Kevin Sanchez, Janos Cambiaso-Daniel, Ileana L Gutierrez, Joan Tran, David N Herndon, Oscar E Suman
Whether burn injury affects boys and men differently is currently unknown. To test the hypothesis that burned boys have lower exercise capacity and exercise training induced responses compared to burned men, forty young boys (12±4 years, 149±20 cm, 46±18 kg) were matched to 35 adult men (33±9 years, 174±10 cm, 84±16 kg) based on extent of burn injury (total body surface area burned, boys 46±14% vs. men 47±30, P=0.85) and length of hospital stay (boys 33±23 vs. men 41±32 days, P=0.23). Strength (peak torque) and cardiorespiratory fitness (peak VO2) were normalized to lean body mass for group comparisons...
December 8, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29568185/thermogenic-blend-alone-or-in-combination-with-whey-protein-supplement-stimulates-fat-metabolism-and-improves-body-composition-in-mice
#11
Paula de Lima Vieira-Brock, Brent M Vaughan, David L Vollmer
Background: Certain food ingredients promote thermogenesis and fat loss. Similarly, whey protein improves body composition. Due to this potential synergistic effect, a blend of thermogenic food ingredients containing African mango, citrus fruit extract, Coleus forskohlii , dihydrocapsiate, and red pepper was tested alone and in combination with a whey protein supplement for its effects on body composition in sedentary mice during high-fat diet. Objective: The objective of this study was to evaluate the interaction of thermogenic foods on improving body composition during consumption of an unhealthy diet...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29523786/cdk6-inhibits-white-to-beige-fat-transition-by-suppressing-runx1
#12
Xiaoli Hou, Yongzhao Zhang, Wei Li, Alexander J Hu, Chi Luo, Wenhui Zhou, Jamie K Hu, Stefano G Daniele, Jinfeng Wang, Jinghao Sheng, Yongsheng Fan, Andrew S Greenberg, Stephen R Farmer, Miaofen G Hu
Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation, enhanced energy expenditure, better glucose tolerance, and improved insulin sensitivity, and are more resistant to high-fat diet-induced obesity. Re-expression of CDK6 in Cdk6 -/- mature or precursor cells, or ablation of RUNX1 in K43M mature or precursor cells, reverses these phenotypes...
March 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29523181/autologous-chyle-fat-grafting-for-the-treatment-of-hypertrophic-scars-and-scar-related-conditions
#13
Xiao Xu, Linying Lai, Xuyi Zhang, Jinhong Chen, Junnan Chen, Fei Wang, Jingchen Zheng, Minliang Chen
BACKGROUND: Scarring is the product of natural restoration, yet its treatment remains challenging. Both collagen and fibroblasts are abnormally abundant in scars, leading to scar hyperplasia or contracture. Several clinical studies have reported that wrinkles at the recipient site are reduced, pores are narrowed, pigmentation is decreased, and skin is softened after autologous fat transplantation. In this study, we investigated the ability of autologous chyle fat injection to normalize the fibroblasts and collagen of scar tissue in 80 adult patients with hypertrophic scars resulting from severe burns received more than 1 year previously...
March 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29514878/nature-s-fat-burning-machine-brown-adipose-tissue-in-a-hibernating-mammal
#14
REVIEW
Mallory A Ballinger, Matthew T Andrews
Brown adipose tissue (BAT) is a unique thermogenic tissue in mammals that rapidly produces heat via nonshivering thermogenesis. Small mammalian hibernators have evolved the greatest capacity for BAT because they use it to rewarm from hypothermic torpor numerous times throughout the hibernation season. Although hibernator BAT physiology has been investigated for decades, recent efforts have been directed toward understanding the molecular underpinnings of BAT regulation and function using a variety of methods, from mitochondrial functional assays to 'omics' approaches...
March 7, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29514439/genetic-parameters-for-marbling-and-body-score-in-anglonubian-goats-using-bayesian-inference-via-threshold-and-linear-models
#15
Luiz Antonio Silva Figueiredo Filho, José Lindenberg Rocha Sarmento, José Elivalto Guimarães Campelo, Marcos Jacob de Oliveira Almeida, Antonio de Sousa Júnior, Natanael Pereira da Silva Santos, Márcio da Silva Costa, Tatiana Saraiva Torres, Luciano Silva Sena
Objective: The aim of this study was to estimate (co) variance components and genetic parameters for categorical carcass traits using Bayesian inference via mixed linear and threshold animal models in Anglonubian goats. Methods: Data were obtained from Anglonubian goats reared in the Brazilian Mid-North region. The traits in study were body condition score, marbling in the rib eye, ribeye area, fat thickness of the sternum, hip height, leg perimeter, and body weight...
March 2, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29482594/tracheal-injury-detected-immediately-after-median-sternotomy-by-inexperienced-surgeons-two-case-reports
#16
Jun Takeshita, Kei Nishiyama, Atsushi Fukumoto, Suguru Ohira, Satoru Beppu, Nozomu Sasahashi, Nobuaki Shime
BACKGROUND: Although median sternotomy is standard during cardiac surgery, the procedure is associated with a risk of injury to mediastinal organs. Here, we discuss two cases of tracheal injury following median sternotomy during cardiac surgery. CASE PRESENTATION: Ventilation failure occurred in a 78-year-old Japanese man and a 71-year-old Japanese man after median sternotomy, and tracheal injury was identified. The sites of injury were directly repaired and covered with mediastinal fat tissue, following which ventilation was successful...
February 27, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29467914/comprehensive-review-and-case-study-on-the-management-of-buried-penis-syndrome-and-related-panniculectomy
#17
Hadley Burns, J Stephen Gunn, Saeed Chowdhry, Thomas Lee, Steven Schulz, Bradon J Wilhelmi
Objective: This paper discusses the various surgical techniques and outcomes associated with management of buried penis syndrome. Methods: Presented is the case of a 49-year-old man with morbid obesity, leading to massive panniculus and buried penis. We review our technique for reconstruction of the buried penis and treatment of the overlying large panniculus. Literature search was conducted to review current techniques in correcting buried penis syndrome. Results: The patient underwent a successful panniculectomy with removal of all excess skin and tissue...
2018: Eplasty
https://www.readbyqxmd.com/read/29403186/innovative-usage-of-accessory-auricles-as-full-thickness-skin-graft
#18
Elankumar Subbarayan, Ravikumar Chittoria
Accessory auricles are relatively rare malformations arising from the first branchial arch which contains skin, fat and cartilage. The treatment is usually surgical removal for the cosmetic purpose. We are sharing our experience of utilising the accessory auricle skin as full thickness graft for post.burn reconstruction of the fingers contracture of a child. Even though this type of association is rare, it is an innovative idea following Sir Harold Gilles' principle 'Never throw anything away'.
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29373534/betaine-supplementation-enhances-lipid-metabolism-and-improves-insulin-resistance-in-mice-fed-a-high-fat-diet
#19
Jingjing Du, Linyuan Shen, Zhendong Tan, Peiwen Zhang, Xue Zhao, Yan Xu, Mailing Gan, Qiong Yang, Jideng Ma, An'an Jiang, Guoqing Tang, Yanzhi Jiang, Long Jin, Mingzhou Li, Lin Bai, Xuewei Li, Jinyong Wang, Shunhua Zhang, Li Zhu
Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease, certain cancers, and insulin resistance. However, there are no effective drugs to treat obesity. Betaine is a nontoxic, chemically stable and naturally occurring molecule. This study shows that dietary betaine supplementation significantly inhibits the white fat production in a high-fat diet (HFD)-induced obese mice. This might be due to betaine preventing the formation of new white fat (WAT), and guiding the original WAT to burn through stimulated mitochondrial biogenesis and promoting browning of WAT...
January 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29370733/food-derived-regulatory-factors-against-obesity-and-metabolic-syndrome
#20
Teruo Kawada
Obesity is a key factor in metabolic syndrome. The study of metabolic syndrome focuses on the anti-weight gain properties of physiological mechanisms and food components. Abnormal energy metabolism is a major risk factor of metabolic syndrome. Chronic inflammation is a feature of obesity; cytokines from hypertrophied adipocytes cause inflammation in both adipose tissue and blood vessels, resulting in symptoms of metabolic syndrome. Tumor necrosis factor-α causes insulin resistance in adipocytes and regression of brown adipocytes, resulting in abnormal energy metabolism...
April 2018: Bioscience, Biotechnology, and Biochemistry
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