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https://www.readbyqxmd.com/read/28814014/bio-inspired-control-of-joint-torque-and-knee-stiffness-in-a-robotic-lower-limb-exoskeleton-using-a-central-pattern-generator
#1
Stefan O Sobrade, Yannik Nager, Amy R Wu, Roger Gassert, Auke Ijspeert
Robotic lower limb exoskeletons are becoming increasingly popular in therapy and recreational use. However, most exoskeletons are still rather limited in their locomotion speed and the activities of daily live they can perform. Furthermore, they typically do not allow for a dynamic adaptation to the environment, as they are often controlled with predefined reference trajectories. Inspired by human leg stiffness modulation during walking, variable stiffness actuators increase flexibility without the need for more complex controllers...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813732/gastric-zygomycosis-in-a-previously-healthy-56-year-old-male
#2
Ashwyna Sunassee, Desirae M Muirhead
Zygomycosis refers to invasive fungal infections caused by fungi belonging to the phylum zygomycota. Infections generally occur in immunocompromised individuals. The following case is of a previously healthy 56 year-oldmale admitted to the hospital following a motor vehicle accident. During his hospitalization, there was a significant drop in hemoglobin with no obvious source of bleeding. This prompted the clinician to insert a nasogastric tube which returned at least 2 liters of black fluid and led to an upper gastrointestinal endoscopy...
April 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813542/the-african-cholera-surveillance-network-africhol-consortium-meeting-10-11-june-2015-lom%C3%A3-togo
#3
Aline Munier, Berthe-Marie Njanpop-Lafourcade, Delphine Sauvageot, Raymond B Mhlanga, Léonard Heyerdahl, Johara Nadri, Richard Wood, Issaka Ouedraogo, Alexandre Blake, Laurent Akilimali Mukelenge, Jean-Claude B Anné, Abiba Banla Kere, Lucienne Dempouo, Sakoba Keita, José P M Langa, Issa Makumbi, Elibariki R Mwakapeje, Ian J Njeru, Olubunmi E Ojo, Isaac Phiri, Lorenzo Pezzoli, Bradford D Gessner, Martin Mengel
The fifth annual meeting of the African cholera surveillance network (Africhol) took place on 10-11 June 2015 in Lomé, Togo. Together with international partners, representatives from the 11 member countries -Cameroon, Côte d'Ivoire, Democratic Republic of Congo, Guinea, Kenya, Mozambique, Nigeria, Tanzania, Togo, Uganda, Zimbabwe- and an invited country (Malawi) shared their experience. The meeting featured three sessions: i) cholera surveillance, prevention and control in participating countries, ii) cholera surveillance methodology, such as cholera mapping, cost-effectiveness studies and the issue of overlapping epidemics from different diseases, iii) cholera laboratory diagnostics tools and capacity building...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28813536/tuberculosis-patients-in-an-indian-mega-city-where-do-they-live-and-where-are-they-diagnosed
#4
Ramnath Subbaraman, Beena E Thomas, Senthil Sellappan, Chandra Suresh, Lavanya Jayabal, Savari Lincy, Agnes L Raja, Allison McFall, Sunil Suhas Solomon, Kenneth H Mayer, Soumya Swaminathan
OBJECTIVE: Tuberculosis (TB) is a major source of mortality in urban India, with many structural challenges to optimal care delivery. In the government TB program in Chennai, India's fourth most populous city, there is a 49% gap between the official number of smear-positive TB patients diagnosed and the official number registered in TB treatment within the city in 2014. We hypothesize that this "urban registration gap" is partly due to rural patients temporarily visiting the city for diagnostic evaluation...
2017: PloS One
https://www.readbyqxmd.com/read/28813251/genetic-differential-susceptibility-to-the-effects-of-parenting
#5
REVIEW
Jay Belsky, Marinus H van IJzendoorn
Intervention efforts aimed at remediating or preventing problems in children typically prove only moderately effective due to substantial heterogeneity in their efficacy. It thus becomes important to account for such variation in intervention efficacy. Here we summarize illustrative evidence that, due to their genetic make-up, some children benefit more from interventions targeting parenting than do others. Whereas some work documents the role of single, 'candidate' genes, other work reveals the utility of compositing multiple genes and genetic pathways...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813123/pharmacotherapy-for-hypertension-in-adults-aged-18-to-59-years
#6
REVIEW
Vijaya M Musini, Francois Gueyffier, Lorri Puil, Douglas M Salzwedel, James M Wright
BACKGROUND: Hypertension is an important risk factor for adverse cardiovascular events including stroke, myocardial infarction, heart failure and renal failure. The main goal of treatment is to reduce these events. Systematic reviews have shown proven benefit of antihypertensive drug therapy in reducing cardiovascular morbidity and mortality but most of the evidence is in people 60 years of age and older. We wanted to know what the effects of therapy are in people 18 to 59 years of age...
August 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28812929/message-received-african-american-women-and-breast-cancer-screening
#7
Susan Racine Passmore, Kester F Williams-Parry, Erica Casper, Stephen B Thomas
African American women are more likely than other women to be diagnosed with breast cancer at a young age, to be diagnosed at a late stage, and to die from the disease. Yet we see evidence of irregular screening and follow-up. Previous research on psychosocial factors influencing decisions to screen reveals barriers: fear, fatalistic perceptions of cancer, inaccurate perceptions of risk, and associations with stigma. The current qualitative research with, largely, insured African American women ( n = 26), health navigators ( n = 6), and community stakeholders ( n = 24) indicates both positive and negative factors influencing decision making...
September 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28812535/associating-mutations-causing-cystinuria-with-disease-severity-with-the-aim-of-providing-precision-medicine
#8
Henry J Martell, Kathie A Wong, Juan F Martin, Ziyan Kassam, Kay Thomas, Mark N Wass
BACKGROUND: Cystinuria is an inherited disease that results in the formation of cystine stones in the kidney, which can have serious health complications. Two genes (SLC7A9 and SLC3A1) that form an amino acid transporter are known to be responsible for the disease. Variants that cause the disease disrupt amino acid transport across the cell membrane, leading to the build-up of relatively insoluble cystine, resulting in formation of stones. Assessing the effects of each mutation is critical in order to provide tailored treatment options for patients...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28812379/dietary-polyphenols-for-atherosclerosis-a-comprehensive-review-and-future-perspectives
#9
Roodabeh Bahramsoltani, Farnaz Ebrahimi, Mohammad Hosein Farzaei, Armaghan Baratpourmoghaddam, Pardis Ahmadi Borkani, Pourouchista Rostamiasrabadi, Amir Hosein Rasouli Amirabadi, Roja Rahimi
Atherosclerosis is one of the most prevalent reasons for premature death in adults. Despite the several conventional drugs in the market; many patients are not completely treated. Here we comprehensively review current clinical evidence regarding the efficacy of dietary polyphenols in atherosclerosis and related complications. PubMed, Cochrane library and Scopus were searched from inception until August 2016 to obtain clinical trials in which polyphenols were evaluated in cardiovascular parameters related to atherosclerosis...
August 16, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28812307/the-development-of-perceptual-averaging-learning-what-to-do-not-just-how-to-do-it
#10
Pete R Jones, Tessa M Dekker
The mature visual system condenses complex scenes into simple summary statistics (e.g., average size, location, orientation, etc.). However, children, often perform poorly on perceptual averaging tasks. Children's difficulties are typically thought to represent the suboptimal implementation of an adult-like strategy. This paper examines another possibility: that children actually make decisions in a qualitatively different way to adults (optimal implementation of a non-ideal strategy). Ninety children (6-7, 8-9, 10-11 years) and 30 adults were asked to locate the middle of randomly generated dot-clouds...
August 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28812205/values-in-time-discounting
#11
Conrad Heilmann
Controversies about time discounting loom large in decisions about climate change. Prominently, a particularly controversial debate about time discounting in climate change decision-making has been conducted within climate economics, between the authors of Stern et al. (Stern review on the economics of climate change, 2006) and their critics (most prominently Dasgupta in Comments on the Stern review's economics of climate change, 2006; Tol in Energy Environ 17(6):977-981, 2006; Weitzman in J Econ Lit XLV:703-724, 2007; Nordhaus in J Econ Lit XLV:686-702, 2007)...
August 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28811984/acdf-graft-selection-by-surgeons-survey-of-aospine-members
#12
S Tim Yoon, Jeffrey A Konopka, Jeffrey C Wang, Jim A Youssef, Hans Joerg Meisel, Darrel S Brodke, Jong-Beom Park
STUDY DESIGN: Cross-sectional survey study. OBJECTIVE: To determine what are the most commonly used graft materials in anterior cervical discectomy and fusion and whether the choice of graft is affected by surgeon's training, years in practice, geographic location, practice setting, or surgeon's perceived difficulty in achieving fusion. METHODS: A 23-question survey was sent out to 5334 surgeons using the Global AO Spine database. Response data was then stratified into surgeon training, years of practice, practice type, and global region...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811788/clinical-results-of-femoral-head-fracture-dislocation-treated-according-to-the-pipkin-classification
#13
Xiao Yu, Qing-Jiang Pang, Xian-Jun Chen
OBJECTIVE: To summarize the clinical results of femoral head fracture-dislocation treated according to Pipkin classification. METHODS: Atotal of 19 patients with femoral head fracture-dislocation were retrospectively analyzed from Mar. 2008 to Mar. 2015. According to the classification of Pipkin criteria, there were 4 cases in Type-I, 6 cases in Type-II, 6 cases in Type-IIIand 3 cases in Type-IV. Various procedures were taken according to the different types of the fracture, the time of the fracture, and the age of the patients...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811267/app-a%C3%AE-structural-diversity-and-alzheimer-s-disease-pathogenesis
#14
REVIEW
Alex E Roher, Tyler A Kokjohn, Steven G Clarke, Michael R Sierks, Chera L Maarouf, Geidy E Serrano, Marwan S Sabbagh, Thomas G Beach
The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1-40 and 1-42 peptides. However, alternative APP proteolytic processing produces a complex roster of Aβ species. In addition, Aβ peptides are subject to extensive posttranslational modification (PTM). We propose that amplified production of some APP/Aβ species, perhaps exacerbated by differential gene expression and reduced peptide degradation, creates a diverse spectrum of modified species which disrupt brain homeostasis and accelerate AD neurodegeneration...
August 12, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28811057/an-integrative-review-of-social-determinants-of-health-assessment-and-screening-tools-used-in-pediatrics
#15
REVIEW
Jennifer Morone
PROBLEM: Social and physical contexts which make up social determinants of health (SDOH) have tremendous impacts on youth development, health and well-being. Despite knowledge and evidence of these impacts, few pediatric SDOH screening tools are known. The purpose of this review was to identify and evaluate available pediatric SDOH screening tools. ELIGIBILITY CRITERIA: Articles were limited to studies in the English language, with pediatric populations, conducted in the United States, and were peer-reviewed, primary studies...
August 12, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28811050/vaccine-decision-making-begins-in-pregnancy-correlation-between-vaccine-concerns-intentions-and-maternal-vaccination-with-subsequent-childhood-vaccine-uptake
#16
M H Danchin, J Costa-Pinto, K Atwell, H Willaby, K Wiley, M Hoq, J Leask, K P Perrett, Jacinta O'Keefe, M L Giles, H Marshall
INTRODUCTION: Maternal and childhood vaccine decision-making begins prenatally. Amongst pregnant Australian women we aimed to ascertain vaccine information received, maternal immunisation uptake and attitudes and concerns regarding childhood vaccination. We also aimed to determine any correlation between a) intentions and concerns regarding childhood vaccination, (b) concerns about pregnancy vaccination, (c) socioeconomic status (SES) and (d) uptake of influenza and pertussis vaccines during pregnancy and routine vaccines during childhood...
August 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28811044/learning-how-to-teach-one-a-needs-assessment-of-the-state-of-faculty-development-within-the-consortium-of-the-american-college-of-surgeons-accredited-education-institutes
#17
John T Paige, Nehal N Khamis, Jeffrey B Cooper
BACKGROUND: Developing faculty competencies in curriculum development, teaching, and assessment using simulation is critical for the success of the Consortium of the American College of Surgeons Accredited Education Institutes program. The state of and needs for faculty development in the Accredited Education Institute community are unknown currently. The Faculty Development Committee of the Consortium of the Accredited Education Institutes conducted a survey of Accredited Education Institutes to ascertain what types of practices are used currently, with what frequency, and what needs are perceived for further programs and courses to guide the plan of action for the Faculty Development Committee...
August 12, 2017: Surgery
https://www.readbyqxmd.com/read/28811018/direct-coupling-of-electromembrane-extraction-to-mass-spectrometry-advancing-the-probe-functionality-toward-measurements-of-zwitterionic-drug-metabolites
#18
Torstein Kige Rye, David Fuchs, Stig Pedersen-Bjergaard, Nickolaj Jacob Petersen
A triple-flow electromembrane extraction (EME) probe was developed and coupled directly to electrospray-ionization mass spectrometry (ESI-MS). Metabolic reaction mixtures (pH 7.4) containing drug substances and related metabolites were continuously drawn (20 μL/min) into the EME probe in one flow channel, and mixed inside the probe with 7.5 μL min(-1) of 1 M formic acid as make-up flow from a second flow channel. Following this acidification, the drug substances and their related metabolites were continuously extracted by EME at 400 V, across a supported liquid membrane (SLM) comprising 2-nitrophenyl octyl ether (and for some experiments containing 30% triphenyl phosphate (TPP)), and into 20 μL min(-1) of formic acid as acceptor phase, which was introduced through a third flow channel...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28810979/women-veterans-a-population-at-risk-for-fibromyalgia-the-associations-between-fibromyalgia-symptoms-and-quality-of-life
#19
Rita F D'Aoust, Alicia Gill Rossiter, Amanda Elliott, Ming Ji, Cecile Lengacher, Maureen Groer
BACKGROUND: The Institute of Federal Health Care recently published an executive summary from a round table discussion indicating that active duty and retired female military personnel are at high risk for adverse health outcomes unique to military service including complications related to post-traumatic stress disorder (PTSD), unreported sexual trauma, and musculoskeletal problems. In 2008, the Institute of Medicine began to review, evaluate, and summarize the literature on health outcomes in Gulf War-deployed and found sufficient evidence of a causal relationship with PTSD and suggestive evidence of an association with fibromyalgia (FM)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810902/the-isotype-and-igg-subclass-distribution-of-anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis-patients
#20
Myrthe A M van Delft, Marije K Verheul, Leonie E Burgers, Veerle F A M Derksen, Annette H M van der Helm-van Mil, Diane van der Woude, Tom W J Huizinga, René E M Toes, Leendert A Trouw
BACKGROUND: Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the breadth and molecular make-up of the anti-CarP antibody response is ill defined. To understand the anti-CarP antibody immune response and potential immune effector mechanisms it can recruit, we determined the anti-CarP antibody isotype and IgG-subclass usage in RA patients...
August 15, 2017: Arthritis Research & Therapy
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