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https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#1
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28092717/the-culture-war-modern-economics-and-environmental-education-in-the-united-states
#2
Eugene C Hargrove
Teaching ethics in public schools in the United States has been made almost impossible because of the Culture War and Modern Economics. When Catholics began to migrate to the United States in the early nineteenth century, they found that Protestant religion and ethics were taught in public schools and they created their own parochial schools. This controversy has continued for two hundred years. To encourage the Catholics to send their children to the public schools, by 1860 religion and ethics had been removed from the public schools...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092557/single-image-super-resolution-using-global-regression-based-on-multiple-local-linear-mappings
#3
Jae-Seok Choi, Munchurl Kim
Super-resolution (SR) has become more vital, because of its capability to generate high-quality ultra-high definition (UHD) high-resolution (HR) images from low-resolution (LR) input images. Conventional SR methods entail high computational complexity, which makes them difficult to be implemented for up-scaling of full-high-definition (FHD) input images into UHD-resolution images. Nevertheless, our previous super-interpolation (SI) method showed a good compromise between PSNR performances and computational complexity...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28091736/salvage-therapy-for-acute-chemorefractory-leukemia-by-allogeneic-stem-cell-transplantation-the-korean-experience
#4
Shin Hye Yoo, Youngil Koh, Dae-Young Kim, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Lee, Sung-Soo Yoon, Seonyang Park, Sung-Kyu Park, Dae-Sik Hong, Hyeon Gyu Yi, Chul-Soo Kim, Ji Eun Jang, June-Won Cheong, Joonho Moon, Yoo Hong Min, Sang Kyun Sohn, Inho Kim
Little is known about the characteristics that make patients with acute leukemia suitable for undergoing salvage therapy by allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we analyzed the clinical outcomes of 223 patients with acute leukemia who underwent allo-HSCT while not in complete remission (CR). The primary end points were overall survival (OS) and CR rate. CR was achieved in 79.8% of patients after allo-HSCT. Acute graft-versus-host disease (GVHD) was significantly associated with CR (P = 0...
January 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28090644/evaluation-of-a-telehealth-training-package-to-remotely-train-staff-to-conduct-a-preference-assessment
#5
William J Higgins, Kevin C Luczynski, Regina A Carroll, Wayne W Fisher, Oliver C Mudford
Recent advancements in telecommunication technologies make it possible to conduct a variety of healthcare services remotely (e.g., behavioral-analytic intervention services), thereby bridging the gap between qualified providers and consumers in isolated locations. In this study, web-based telehealth technologies were used to remotely train direct-care staff to conduct a multiple-stimulus-without-replacement preference assessment. The training package included three components: (a) a multimedia presentation; (b) descriptive feedback from previously recorded baseline sessions; and (c) scripted role-play with immediate feedback...
January 16, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28090512/surgical-applications-of-three-dimensional-printing-a-review-of-the-current-literature-how-to-get-started
#6
REVIEW
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi
Three dimensional (3D) printing involves a number of additive manufacturing techniques that are used to build structures from the ground up. This technology has been adapted to a wide range of surgical applications at an impressive rate. It has been used to print patient-specific anatomic models, implants, prosthetics, external fixators, splints, surgical instrumentation, and surgical cutting guides. The profound utility of this technology in surgery explains the exponential growth. It is important to learn how 3D printing has been used in surgery and how to potentially apply this technology...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090446/quantitative-imaging-methods-in-osteoporosis
#7
REVIEW
Ling Oei, Fjorda Koromani, Fernando Rivadeneira, M Carola Zillikens, Edwin H G Oei
Osteoporosis is characterized by a decreased bone mass and quality resulting in an increased fracture risk. Quantitative imaging methods are critical in the diagnosis and follow-up of treatment effects in osteoporosis. Prior radiographic vertebral fractures and bone mineral density (BMD) as a quantitative parameter derived from dual-energy X-ray absorptiometry (DXA) are among the strongest known predictors of future osteoporotic fractures. Therefore, current clinical decision making relies heavily on accurate assessment of these imaging features...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090401/insights-in-public-health-challenges-investigating-health-outcomes-in-chinese-americans-using-population-based-survey-data
#8
Michelle Tong, Tetine Sentell
Chinese Americans constitute the largest percentage of Asian Americans. In Hawai'i, Chinese Americans make up approximately 4.7% of the total state population. Accurately assessing health disparities across specific Asian American subgroups is critically important to health research and policy, as there is often substantial variability in risk and outcomes. However, even for Chinese Americans, the largest of the Asian American subgroups, such analyses can present challenges in population-based surveys. This article considers these challenges generally and then specifically in terms of the issue of health literacy and heart disease in Chinese Americans using existing population-based survey data sets in the United States, California, and Hawai'i...
January 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28090146/rapid-weight-loss-in-the-context-of-ramadan-observance-recommendations-for-judokas
#9
REVIEW
A Aloui, H Chtourou, W Briki, M Tabben, A Chaouachi, N Souissi, R J Shephard, K Chamari
Judo is a weight-classified combat sport, and many athletes seek to compete at the lightest possible weight category to gain an advantage from competing against shorter/smaller, and supposedly weaker opponents. To achieve a desired weight, most judokas opt for rapid weight loss techniques. Short-duration maximal efforts are not greatly affected by "making weight", but prolonged and/or repeated exercise is significantly impaired. Negative effects on mood, ratings of perceived exertion, and cognitive function are also reported...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28089723/cost-effectiveness-of-the-decipher-genomic-classifier-to-guide-individualized-decisions-for-early-radiation-therapy-after-prostatectomy-for-prostate-cancer
#10
Jennifer M Lobo, Daniel M Trifiletti, Vanessa N Sturz, Adam P Dicker, Christine Buerki, Elai Davicioni, Matthew R Cooperberg, R Jeffrey Karnes, Robert B Jenkins, Robert B Den, Timothy N Showalter
BACKGROUND: Controversy exists regarding the effectiveness of early adjuvant versus salvage radiation therapy after prostatectomy for prostate cancer. Estimates of prostate cancer progression from the Decipher genomic classifier (GC) could guide informed decision-making and improve the outcomes for patients. MATERIALS AND METHODS: We developed a Markov model to compare the costs and quality-adjusted life years (QALYs) associated with GC-based treatment decisions regarding adjuvant therapy after prostatectomy with those of 2 control strategies: usual care (determined from patterns of care studies) and the alternative of 100% adjuvant radiation therapy...
August 17, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28089592/stapleless-laparoscopic-sleeve-gastrectomy-preliminary-report
#11
Jose Luis Leyba, Salvador Navarrete Llopis, Salvador Navarrete Aulestia, Ricardo Ochoa, Eliana Azuaje
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) as a single-stage procedure for the treatment of morbid obesity is becoming increasingly popular. In undeveloped countries, the linear staples required to create the sleeve are not always available because of their high cost. As an alternative to the staples, the bipolar vessel sealer device could be used in bariatric surgery to divide and temporarily seal the stomach. SETTINGS: Universidad Central de Venezuela, Caracas, Venezuela...
December 7, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28089207/delivery-dilemmas-how-drug-cryptomarket-users-identify-and-seek-to-reduce-their-risk-of-detection-by-law-enforcement
#12
Judith Aldridge, Rebecca Askew
BACKGROUND: Cryptomarkets represent an important drug market innovation by bringing buyers and sellers of illegal drugs together in a 'hidden' yet public online marketplace. We ask: How do cryptomarket drug sellers and buyers perceive the risks of detection and arrest, and attempt to limit them? METHODS: We analyse selected texts produced by vendors operating on the first major drug cryptomarket, Silk Road (N=600) alongside data extracted from the marketplace discussion forum that include buyer perspectives...
January 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28088984/the-aging-hematopoietic-stem-cell-niche-phenotypic-and-functional-changes-and-mechanisms-that-contribute-to-hematopoietic-aging
#13
REVIEW
Sarah E Latchney, Laura M Calvi
The hematopoietic system has the remarkable ability to provide a lifelong supply of mature cells that make up the entire blood and immune system. However, similar to other adult stem cell niches, the hematopoietic system is vulnerable to the detrimental effects of aging. This is a substantial health concern as the trend for population aging continues to increase. Identifying mechanisms that underlie hematopoietic aging is vital for understanding hematopoietic-related diseases. In this review, we first discuss the cellular hierarchy of the hematopoietic system and the components that make up the surrounding hematopoietic niche...
January 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28088983/the-epigenetic-basis-of-hematopoietic-stem-cell-aging
#14
REVIEW
Ashley Kramer, Grant A Challen
Highly proliferative tissues such as the gut, skin, and bone marrow lose millions of cells each day to normal attrition and challenge from different biological adversities. To achieve a lifespan beyond the longevity of individual cell types, tissue-specific stem cells sustain these tissues throughout the life of a human. For example, the lifespan of erythrocytes is about 100 days and adults make about two million new erythrocytes every second. A small pool of hematopoietic stem cells (HSCs) in the bone marrow is responsible for the lifetime maintenance of these populations...
January 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/28088843/evaluating-surrogate-marker-information-using-censored-data
#15
Layla Parast, Tianxi Cai, Lu Tian
Given the long follow-up periods that are often required for treatment or intervention studies, the potential to use surrogate markers to decrease the required follow-up time is a very attractive goal. However, previous studies have shown that using inadequate markers or making inappropriate assumptions about the relationship between the primary outcome and surrogate marker can lead to inaccurate conclusions regarding the treatment effect. Currently available methods for identifying and validating surrogate markers tend to rely on restrictive model assumptions and/or focus on uncensored outcomes...
January 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28088359/argentation-chromatography-coupled-to-ultrahigh-resolution-mass-spectrometry-for-the-separation-of-a-heavy-crude-oil
#16
Lilla Molnárné Guricza, Wolfgang Schrader
Simplification of highly complex mixtures such as crude oil by using chromatographic methods makes it possible to get more detailed information about the composition of the analyte. Separation by argentation chromatography can be achieved based on the interaction of different strength between the silver ions (Ag(+)) immobilized through a spacer on the silica gel surface and the π-bonds of the analytes. Heavy crude oils contain compounds with a high number of heteroatoms (N, O, S) and a high degree of unsaturation thus making them the perfect analyte for argentation chromatography...
December 30, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088214/determinants-and-materno-fetal-outcomes-related-to-cesarean-section-delivery-in-private-and-public-hospitals-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis-protocol
#17
Idrissa Beogo, Bomar Mendez Rojas, Marie-Pierre Gagnon
BACKGROUND: Despite the well-established morbidity, mortality, long-term effects, and unnecessary extra-cost burden associated with cesarean section delivery (CSD) worldwide, its rate has grown exponentially. This has become a great topical challenge for the international healthcare community and individual countries. Estimated at three times the acceptable rate as defined by the World Health Organization in 1985, the continued upward trend has been fuelled by higher income countries...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28088094/organ-on-a-chip-for-assessing-environmental-toxicants
#18
REVIEW
Soohee Cho, Jeong-Yeol Yoon
Man-made xenobiotics, whose potential toxicological effects are not fully understood, are oversaturating the already-contaminated environment. Due to the rate of toxicant accumulation, unmanaged disposal, and unknown adverse effects to the environment and the human population, there is a crucial need to screen for environmental toxicants. Animal models and in vitro models are ineffective models in predicting in vivo responses due to inter-species difference and/or lack of physiologically-relevant 3D tissue environment...
January 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28087896/eag-channels-expressed-in-microvillar-photoreceptors-are-unsuited-to-diurnal-vision
#19
Esa-Ville Immonen, Andrew S French, Päivi H Torkkeli, Hongxia Liu, Mikko Vähäsöyrinki, Roman V Frolov
The principles underlying evolutionary selection of ion channels for expression in sensory neurons are unclear. Among species possessing microvillar photoreceptors the major ionic conductances have only been identified in Drosophila melanogaster. In Drosophila depolarization is provided by light-activated TRP channels with a minor contribution from TRPL channels, while repolarization is mediated by sustained voltage-gated K(+) (Kv) channels of the Shab family. Bright light stimulates Shab channels, further restricting depolarization and improving membrane bandwidth...
January 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28087812/long-term-effects-of-youth-unemployment-on-mental-health-does-an-economic-crisis-make-a-difference
#20
Emelie Thern, Jeroen de Munter, Tomas Hemmingsson, Finn Rasmussen
BACKGROUND: Ill health is a risk factor and a consequence of unemployment, which might vary depending on the national rate of unemployment. We investigated the long-term effect of youth unemployment on mental health and explored the possible interaction during periods of high (economic crisis) and low (non-crisis) unemployment rates. METHODS: A register-linked population-based cohort study was conducted including individuals aged 17-24 years. The crisis cohort (n=6410) took part in the Labour Force Survey during the economic crisis (1991-1994) in Sweden and the non-crisis cohort (n=8162) took part in the same survey before the crisis (1983-1986)...
January 13, 2017: Journal of Epidemiology and Community Health
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