keyword
MENU ▼
Read by QxMD icon Read
search

palliative approach

keyword
https://www.readbyqxmd.com/read/29222299/management-of-multiple-myeloma-in-the-relapsed-refractory-patient
#1
REVIEW
Pieter Sonneveld
The approach to the patient with relapsed or relapsed/refractory multiple myeloma requires a careful evaluation of the results of previous treatments, the toxicities associated with it, and an assessment of prognostic factors. The majority of patients will have received prior therapy with drug combinations, including a proteasome inhibitor and an immune-modulatory agent. It is the physician's task to choose the right moment for the start of therapy and decide with the patient which goals need to be achieved...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221687/leptomeningeal-carcinomatosis-in-colorectal-cancer-the-mayo-clinic-experience
#2
Gretchen Taylor, Nina Karlin, Thorvardur R Halfdanarson, Kyle Coppola, Axel Grothey
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon form of metastatic disease in many cancers. There remains a paucity of literature with regard to the course and management of LM in colorectal cancers (CRCs). The aim of this study was to estimate the incidence of LM in patients with CRC seen at our institution over a 15-year period, and to describe the clinical course and outcome of these cases. METHODS: LM in CRC primary cases between 2000 and 2014 were identified in the Mayo Clinic databases...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29221475/a-critical-realist-evaluation-of-a-music-therapy-intervention-in-palliative-care
#3
Sam Porter, Tracey McConnell, Mike Clarke, Jenny Kirkwood, Naomi Hughes, Lisa Graham-Wisener, Joan Regan, Miriam McKeown, Kerry McGrillen, Joanne Reid
BACKGROUND: Music therapy is increasingly used as an adjunct therapy to support symptom management in palliative care. However, studies to date have paid little attention to the processes that lead to changes in patient outcomes. To fill this gap, we examined the processes and experiences involved in the introduction of music therapy as an adjunct complementary therapy to palliative care in a hospice setting in the United Kingdom (UK). METHODS: Using a realistic evaluation approach, we conducted a qualitative study using a variety of approaches...
December 8, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29220298/gastrointestinal-stromal-tumors
#4
Margaret von Mehren, Heikki Joensuu
GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progressing cancers. GISTs occur throughout the intestinal tract, and most harbor an activating mutation in either KIT or platelet-derived growth factor A ( PDGFRA). Diagnosis is made using immunohistochemistry, but molecular testing with mutation analysis is paramount for selection of appropriate therapy. Most small GISTs are cured with surgery. Tyrosine kinase inhibitor (TKI) therapy has led to substantial improvements in survival, both for patients with localized GIST and those with advanced disease...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29220290/synovial-sarcoma-current-concepts-and-future-perspectives
#5
Silvia Stacchiotti, Brian Andrew Van Tine
Synovial sarcoma (SS) is a rare sarcoma driven by a translocation between SS18 and SSX 1, 2, or 4. With approximately 800 to 1,000 cases a year in the United States, it most commonly affects young adults between the ages of 15 and 30 years. The resultant tumors are either monophasic (pure sarcomas), biphasic (a combination or epithelioid and sarcomatous components), or poorly differentiated. The hybrid transcription factor SS18:SSX alters SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling and global methylation patterns that may allow for future therapeutic opportunities...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29220289/osteosarcoma-chondrosarcoma-and-chordoma
#6
Jeremy S Whelan, Lara E Davis
Osteosarcoma (OS), chondrosarcoma, and chordoma are characterized by multiple challenges to the investigator, clinician, and patient. One consequence of their rarity among sarcomas, as well as their biologic and clinical heterogeneity, is that management guidelines are inadequate to inform the range of individual patient-treatment decisions from diagnosis, approaches to surgery, chemotherapy, radiotherapy, treatment of recurrence, palliative care, and quality of survivorship. Of high-grade sarcomas, OSs are among the most curable, with more than two-thirds of patients with localized disease likely to achieve long-term survival...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29219746/development-of-two-surgical-approaches-to-the-pituitary-gland-in-the-horse
#7
James L Carmalt, Brian A Scansen
BACKGROUND: Current treatment of equine PPID requires daily oral medication, which is expensive and difficult from a management perspective. A minimally invasive surgical palliation of this chronic condition is appealing because it is envisioned to be a single treatment which, while not curative, will alleviate the clinical signs of disease dramatically thereby improving the welfare of the horse. OBJECTIVE: To develop a surgical approach to the equine pituitary gland, for subsequent treatment of pituitary pars intermedia dysfunction...
December 8, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/29212547/restrictive-surgical-approach-to-palliate-angina-in-a-patient-with-coronary-three-vessel-disease-and-biventricular-metastatic-hepatocellular-carcinoma
#8
Angela Kornberger, Tillmann Emrich, Andres Beiras-Fernandez, Christian-Friedrich Vahl
BACKGROUND: Metastatic cardiac tumors may cause different symptoms including angina, symptoms of heart failure and/or arrhythmia. In patients with concomitant coronary artery disease, it may be difficult to distinguish between angina caused by metastases to the heart, for example, by stealing perfusion from the coronary arteries, and angina caused by coronary stenosis. Identifying the origin of the symptoms is, however, essential for designing appropriate surgical strategies. CASE PRESENTATION: A 69-year-old male with multifocal recurrence of a hepatocellular carcinoma (HCC) presented with increasing ventricular arrhythmia and angina several weeks after posterior myocardial infarction and PCI of the RCA culprit lesion during which two further lesions present in the distal RCX and a posterolateral branch, and a chronically occluded LAD had not been addressed...
December 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29211657/open-to-air-is-a-viable-option-for-initial-wound-care-in-necrotizing-soft-tissue-infection-that-allows-early-detection-of-recurrence-without-need-for-painful-dressing-changes-or-return-to-operating-room
#9
Derek Yang, April Davies, Bailey Burge, Phillip Watkins, Sharmila Dissanaike
BACKGROUND: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint...
December 6, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29209424/severe-copd-and-the-transition-to-a-palliative-approach
#10
Amanda Landers, Rachel Wiseman, Suzanne Pitama, Lutz Beckert
Patients with severe chronic obstructive pulmonary disease (COPD) have a chaotic trajectory towards death. Research has focused on identifying a "transition point" that would allow identification of those patients who may benefit from a palliative approach to their care, or referral to a specialist palliative care service. This article aims to outline difficulties in identifying this transition point, summarise current literature on this topic and suggests a model based on clinical milestones. Educational aims: To outline the difficulties associated with identifying patients with severe COPD who are at risk of dying...
December 2017: Breathe
https://www.readbyqxmd.com/read/29204525/sbrt-to-adrenal-metastases-provides-high-local-control-with-minimal-toxicity
#11
Kristin Plichta, Nathan Camden, Muhammed Furqan, Taher Abu Hejleh, Gerald H Clamon, Jun Zhang, Ryan T Flynn, Sudershan K Bhatia, Mark C Smith, John M Buatti, Bryan G Allen
Purpose: The adrenal glands are a common site of metastases because of their rich blood supply. Previously, adrenal metastases were treated with systemic chemotherapy or, more rarely, with surgical resection or palliative radiation therapy. Stereotactic body radiation therapy (SBRT) has recently emerged as an attractive noninvasive approach to definitively treat these lesions. We present our experience in treating adrenal metastases using SBRT and review the current literature. Methods and materials: This is a single-institution retrospective review of patients who received SBRT to adrenal metastases originating from various primary malignancies...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29202863/a-novel-family-dignity-intervention-fdi-for-enhancing-and-informing-holistic-palliative-care-in-asia-study-protocol-for-a-randomized-controlled-trial
#12
Andy Hau Yan Ho, Josip Car, Moon-Ho Ringo Ho, Geraldine Tan-Ho, Ping Ying Choo, Paul Victor Patinadan, Poh Heng Chong, Wah Ying Ong, Gilbert Fan, Yee Pin Tan, Robert A Neimeyer, Harvey M Chochinov
BACKGROUND: The lack of a holistic approach to palliative care can lead to a fractured sense of dignity at the end of life, resulting in depression, hopelessness, feelings of being a burden to others, and the loss of the will to live among terminally ill patients. Building on the clinical foundation of Dignity Therapy, together with the empirical understanding of dignity-related concerns of Asian families facing terminal illness, a novel Family Dignity Intervention (FDI) has been developed for Asian palliative care...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29201452/neuroendocrine-tumors-of-the-thymus-the-oncologist-point-of-view
#13
REVIEW
Nicolas Girard
Thymic malignancies represent a heterogeneous group of rare thoracic cancers, which are classified according to the World Health Organization (WHO) histopathologic classification that distinguishes thymomas from thymic carcinomas and neuroendocrine tumors; neuroendocrine thymic tumors (NETTs) exhibit the same histological spectrum as in other anatomical locations, although with different frequencies. NETTs represent around 2% of all neuroendocrine tumors, and about 5% of all thymic malignancies. Overall, the management of patients with NETTs tumors requires continuous multidisciplinary expertise at any step of the disease progression...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29200118/palliative-care-end-of-life-care-and-advance-care-planning-in-neuro-oncology
#14
Tobias Walbert
PURPOSE OF REVIEW: Despite new therapeutic approaches, most patients with high-grade glioma face limited overall survival and have a high symptom burden throughout their disease trajectory, especially in the end-of-life phase. This article provides an overview of the role of palliative care in neuro-oncology. Management recommendations are made for neurologic symptoms in patients with advanced brain tumors, including headaches, nausea, and fatigue. Special attention is given to how and when to involve subspecialty palliative care and hospice services to improve symptom management during active tumor treatment and in the end-of-life phase of patients with brain tumors...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29199689/clinical-profile-of-nonsmall-cell-lung-carcinoma-patients-treated-in-a-single-unit-at-a-tertiary-cancer-care-center
#15
D C Doval, R Sinha, U Batra, K D Choudhury, S Azam, A Mehta
BACKGROUND: Recent advances and understanding in the field of lung cancer and advent of newer treatments have shown a significant improvement in survival in the patients. The present study was conducted to analyze the clinical profile of nonsmall cell lung cancer (NSCLC) patients treated in a single unit at a tertiary cancer care center. MATERIALS AND METHODS: In this retrospective analysis, 322 consecutive NSCLC patients from the year 2011 to 2012 treated in a single unit were included in the study...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199651/is-pulmonary-metastasectomy-beneficial-in-head-and-neck-squamous-cell-carcinoma-a-review-of-literature
#16
REVIEW
N R Subramaniam, R Reddy, D Balasubramanian, K Thankappan, S Iyer
Metastatic head and neck squamous cell carcinoma (HNSCC) has traditionally carried a dismal prognosis; however with advances in care, it has been shown that pulmonary metastasectomy is a viable therapeutic option in selected patients, palliating symptoms and improving survival. With the increasing incidence of human papilloma virus-related HNSCC and better availability of minimal access surgery, there is a need to better understand the role of pulmonary metastasectomy in the treatment of HNSCC. This article summarizes the literature on indications, results, surgical options and approaches, clinical dilemmas, and controversies associated with pulmonary metastasectomy in HNSCC, to identify suitable candidates and optimize outcomes...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29196588/understanding-stage-ii-bidirectional-cavopulmonary-shunts
#17
Cecilia St George-Hyslop, Jennifer Thomas, Linda G Fazari
Despite improvements in surgical technique and medical management, single-ventricle lesions remain one of the most challenging congenital heart anomalies to treat, and mortality rates are high. Most infants who have single-ventricle palliation undergo a sequence of surgeries to optimize pulmonary and systemic blood flow. The first surgery to separate pulmonary and systemic blood flow is the bidirectional cavopulmonary shunt. This article describes single-ventricle lesions and gives a basic overview of outcomes and strategies to improve interstage mortality...
December 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/29193007/outcome-of-relapse-after-allogeneic-hsct-in-children-with-all-enrolled-in-the-all-sct-2003-2007-trial
#18
Michaela Kuhlen, Andre M Willasch, Jean-Hugues Dalle, Jacek Wachowiak, Isaac Yaniv, Marianne Ifversen, Petr Sedlacek, Tayfun Guengoer, Peter Lang, Peter Bader, Sabina Sufliarska, Adriana Balduzzi, Brigitte Strahm, Irene von Luettichau, Jessica I Hoell, Arndt Borkhardt, Thomas Klingebiel, Martin Schrappe, Arend von Stackelberg, Evgenia Glogova, Ulrike Poetschger, Roland Meisel, Christina Peters
Relapse remains the major cause of treatment failure in children with high-risk acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem-cell transplantation (allo-SCT). Prognosis is considered dismal but data on risk factors and outcome are lacking from prospective studies. We analysed 242 children with recurrence of ALL after first allo-SCT enrolled in the Berlin-Frankfurt-Munster (BFM) ALL-SCT-BFM 2003 and ALL-SCT-BFM international 2007 studies. Median time from allo-SCT to relapse was 7·7 months; median follow-up from relapse after allo-SCT until last follow-up was 3·4 years...
November 28, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29186912/computer-aided-drug-design-applied-to-marine-drug-discovery-meridianins-as-alzheimer-s-disease-therapeutic-agents
#19
Laura Llorach-Pares, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Conxita Avila
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug discovery. In this paper, we computationally evaluated and reported the inhibitory activity found in meridianins A-G, a group of marine indole alkaloids isolated from the marine tunicate Aplidium, against various protein kinases involved in Alzheimer's disease (AD), a neurodegenerative pathology characterized by the presence of neurofibrillary tangles (NFT)...
November 27, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29185362/living-with-incurable-cancer-what-are-the-rehabilitation-needs-in-a-palliative-setting
#20
Kirsti Loughran, Sarah Rice, Lisa Robinson
BACKGROUND: Increasing numbers of people are living with incurable cancers. Symptoms, side effects, and treatment burdens impact on physical functioning, yet little is known about the impact on people's lives and how best to provide rehabilitation. MATERIALS AND METHODS: A qualitative study employing a phenomenological approach explored the lived experience of incurable cancer. A purposive sample of six people participated in semi-structured interviews. The data were analysed thematically at a semantic level to identify the functional difficulties experienced by people living with incurable cancer, the meanings of those difficulties, and participants perceived rehabilitation needs...
November 29, 2017: Disability and Rehabilitation
keyword
keyword
117402
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"