keyword
https://read.qxmd.com/read/38547511/operating-properties-of-disease-activity-indices-in-pediatric-inflammatory-bowel-disease-a-systematic-review
#1
JOURNAL ARTICLE
Ruben J Colman, Virginia Solitano, John K MacDonald, Christopher Ma, Anne M Griffiths, Vipul Jairath, Eileen Crowley
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched on December 6, 2022, to identify studies evaluating clinical, endoscopic, imaging, or patient-reported outcome measures (PROMs) in pIBD including Crohn's disease (CD) and ulcerative colitis (UC)...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547411/perspectives-in-precautionary-allergen-labelling-of-prepackaged-foods-after-the-fao-who-consultation
#2
JOURNAL ARTICLE
Vincenzo Fierro, Carmen Mazzuca, Sara Urbani, Lamia Dahdah, Veronica Calandrelli, Rocco Luigi Valluzzi, Dinardo Giulio
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of the perspectives regarding precautionary allergen labelling (PAL) of prepackaged foods following the consultation conducted by the Food and Agriculture Organization (FAO) and the WHO. RECENT FINDINGS: The FAO/WHO consultation provided a comprehensive assessment of the current status and practices of PAL implementation worldwide. One of the key findings highlighted by the Expert Committee was the need for improvement in existing PAL systems...
March 29, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38547404/assessment-of-associations-between-inhaled-formaldehyde-and-lymphohematopoietic-cancer-through-integration-of-epidemiological-and-toxicological-evidence-with-biological-plausibility
#3
JOURNAL ARTICLE
M J Vincent, S Fitch, L Bylsma, C Thompson, S Rogers, J Britt, D Wikoff
Formaldehyde is recognized as carcinogenic for portal of entry sites, though conclusions are mixed regarding lymphohematopoietic (LHP) cancers. This systematic review assesses the likelihood of a causal relationship between formaldehyde and LHP cancers by integrating components recommended by NASEM. Four experimental rodent bioassays and 16 observational studies in humans were included following implementation of the a priori protocol. All studies were assessed for risk of bias (RoB), and meta-analyses conducted on epidemiological studies, followed by a structured assessment of causation based on GRADE and Bradford Hill...
March 28, 2024: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38547384/detection-of-non-cardiac-fetal-abnormalities-by-ultrasound-at-11-14%C3%A2-weeks-systematic-review-and-meta-analysis
#4
REVIEW
J Karim, D Di Mascio, N Roberts, A T Papageorghiou
OBJECTIVES: To assess diagnostic accuracy of 2D ultrasound at 11-14 weeks gestation as a screening test for individual fetal anomalies and identify screening factors impacting detection. METHODS: Systematic review and meta-analysis, developed and registered with PROSPERO (CRD42018111781). MEDLINE, EMBASE, Web of Science Core Collection and The Cochrane Library) were searched for studies evaluating the diagnostic accuracy of screening for 16 pre-specified, non-cardiac, congenital anomalies considered to be of interest to the early anomaly scan...
March 28, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38547370/heteroionic-interfaces-in-hybrid-solid-state-batteries%C3%A2-current-constriction-at-the-interface-between-different-solid-electrolytes
#5
JOURNAL ARTICLE
Janis K Eckhardt, Sascha Kremer, Leonardo Merola, Jürgen Janek
The requirements for suitable electrolyte materials in solid-state batteries are diverse and vary greatly depending on their role as separator or as part of the composite cathode. Hybrid cell concepts that incorporate different types of solid electrolytes are considered a promising solution to overcome the limitations of single material classes. However, the kinetics at the heteroionic interface (i.e., charge transfer) substantially affects the cell performance. Moreover, non-ideal physical contacts hinder detailed electrochemical characterization of the interface properties...
March 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38547351/an-evaluation-of-mental-health-integration-in-the-neglected-tropical-diseases-program-in-zamfara-north-west-nigeria
#6
JOURNAL ARTICLE
Sunday Udo, Pius Sunday Ogbu, Paul A Tsaku, Aliyu Tukur, Andrew NewMarch
BACKGROUND: Mental health and neglected tropical diseases (NTDs) are critical in healthcare systems, especially in low- and middle-income countries. Several policies are planned or designed by health stakeholders to address the mental health needs of people affected by NTDs. Still, the impact of such policies seems to be of no consequence. METHODS: The GAD-7 and PHQ-9 tools were used to determine the rate of depression and anxiety, respectively, among people affected by skin NTDs (leprosy and lymphatic filariasis [LF]) in Zamfara State, North-west Nigeria...
March 28, 2024: International Health
https://read.qxmd.com/read/38547334/noninvasive-assessment-of-liver-fibrosis-and-portal-hypertension
#7
JOURNAL ARTICLE
Andres Duarte-Rojo, Keyur Patel, Don C Rockey
PURPOSE OF REVIEW: The result of ongoing liver injury - and disease, regardless of cause - is fibrosis, and fibrosis appears to be a critically important result of ongoing injury. Further, in a number of different liver diseases, the presence of fibrosis has prognostic value. Therefore, the assessment of fibrosis is of critical clinical importance. Given the importance of fibrosis, there has been a rapid evolution in the use of noninvasive liver tests. This review highlights a number of the core principles surrounding...
March 29, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38547299/early-prediction-of-the-impact-of-public-health-policies-on-obesity-and-lifetime-risk-of-type-2-diabetes-a-modelling-approach
#8
JOURNAL ARTICLE
Pierre Bauvin, Claire Delacôte, Line Carolle Ntandja Wandji, Guillaume Lassailly, Violeta Raverdy, François Pattou, Sylvie Deuffic-Burban, Philippe Mathurin
OBJECTIVE: Help public health decision-making requires a better understanding of the dynamics of obesity and type 2 diabetes and an assessement of different strategies to decrease their burdens. METHODS: Based on 97,848 individual data, collected in the French Health, Health Care and Insurance Survey over 1998-2014, a Markov model was developed to describe the progression of being overweight to obesity, and the onset of type 2 diabetes. This model traces and predicts 2022-2027 burdens of obesity and type 2 diabetes, and lifetime risk of diabetes, according to different scenarios aiming at minimum to stabilize obesity at 5 years...
2024: PloS One
https://read.qxmd.com/read/38547165/low-cost-iot-based-system-for-lake-water-quality-monitoring
#9
JOURNAL ARTICLE
Kartikay Lal, Sanoj Menon, Frazer Noble, Khalid Mahmood Arif
Water quality monitoring is a critical process in maintaining the well-being of aquatic ecosystems and ensuring growth of the surrounding environment. Clean water supports and maintains the health, livelihoods, and ecological balance of the ecosystem as a whole. Regular assessment of water quality is essential to ensure clean and reliable water is available to everyone. This requires regular measurement of pollutants or contaminants in water that can be monitored in real-time. Hence, this research showcases a system that consists of low-cost sensors used to measure five basic parameters of water quality that are: turbidity, total dissolved solids, temperature, pH, and dissolved oxygen...
2024: PloS One
https://read.qxmd.com/read/38547149/cybersecurity-on-a-budget-evaluating-security-and-performance-of-open-source-siem-solutions-for-smes
#10
JOURNAL ARTICLE
Jawad Manzoor, Abdul Waleed, Abdul Fareed Jamali, Ammar Masood
The proliferation of cyber threats necessitates robust security measures to safeguard critical assets and data in today's evolving digital landscape. Small and Medium Enterprises (SMEs), which are the backbone of the global economy are particularly vulnerable to these threats due to inadequate protection for critical and sensitive information, budgetary constraints, and lack of cybersecurity expertise and personnel. Security Information and Event Management (SIEM) systems have emerged as pivotal tools for monitoring, detecting, and responding to security incidents...
2024: PloS One
https://read.qxmd.com/read/38547142/a-realistic-mixture-of-ubiquitous-persistent-organic-pollutants-affects-bone-and-cartilage-development-in-zebrafish-by-interaction-with-nuclear-receptor-signaling
#11
JOURNAL ARTICLE
Gustavo Guerrero-Limón, Jérémie Zappia, Marc Muller
"Persistent organic pollutants (POPs)" have a plethora of deleterious effects on humans and the environment due to their bioaccumulative, persistent, and mimicking properties. Individually, each of these chemicals has been tested and its effects measured, however they are rather found as parts of complex mixtures of which we do not fully grasp the extent of their potential consequences. Here we studied the effects of realistic, environmentally relevant mixtures of 29 POPs on cartilage and bone development using zebrafish as a model species...
2024: PloS One
https://read.qxmd.com/read/38547141/human-animal-entanglements-in-bushmeat-trading-in-sierra-leone-an-ethnographic-assessment-of-a-potential-zoonotic-interface
#12
JOURNAL ARTICLE
Jack Jenkins, Wahab Lawundeh, Tommy Hanson, Hannah Brown
'Bushmeat' markets are often portrayed as chaotic spaces where exotic wild animals are sold. They are hypothesized to be important sites for zoonotic disease transmission, given the prolonged and intense nature of the cross-species encounters that occur within them. Whilst such markets have received some attention from researchers, rich qualitative descriptions of everyday practices in these markets are rare. Depictions of wild animal markets as sites for potential viral amplification often rely on exoticizing assumptions and narratives rather than actual evidence, and in some cases are based more on ideology than on science...
2024: PloS One
https://read.qxmd.com/read/38547115/efficacy-and-safety-of-biologic-agents-for-iga-nephropathy-a-protocol-for-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Jia Ma, Jianyue Xing, Yupeng Zhang, Guangzhen Liu
BACKGROUND: IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide and a leading cause of chronic kidney failure. There are currently no definitive therapeutic regimens to treat or prevent the progression of IgAN. However, biologic agents offer novel therapeutic approaches that target immunological mechanisms to slow or halt disease progression. The objective of this study is to evaluate the efficacy and safety of biologic agents in patients with IgA nephropathy...
2024: PloS One
https://read.qxmd.com/read/38547091/labor-market-segmentation-and-the-gender-wage-gap-evidence-from-china
#14
JOURNAL ARTICLE
Mingming Li, Yuan Tang, Keyan Jin
Although the Chinese government has implemented a variety of measures, the gender wage gap in 21st century China has not decreased. A significant body of literature has studied this phenomenon using sector segmentation theory, but these studies have overlooked the importance of the collective economy beyond the public and private sectors. Moreover, they have lacked assessment of the gender wage gap across different wage groups, hindering an accurate estimation of the gender wage gap in China, and the formulation of appropriate recommendations...
2024: PloS One
https://read.qxmd.com/read/38547036/implications-of-measles-inclusion-by-commercial-syndromic-polymerase-chain-reaction-panels-united-states-may-2022-april-2023
#15
JOURNAL ARTICLE
Christine M Thomas, Amanda Hartley, Ann Schmitz, Heather D Reid, Susan Sullivan, Elise Huebner, Meredith Robinson, Adria Mathis, Mary-Margaret A Fill, Kara J Levinson, Tim F Jones, William Schaffner, Caitlin N Newhouse, John R Dunn
Syndromic polymerase chain reaction (PCR) panels are used to test for pathogens that can cause rash illnesses, including measles. Rash illnesses have infectious and noninfectious causes, and approximately 5% of persons experience a rash 7-10 days after receipt of a measles, mumps, and rubella (MMR) vaccine. MMR vaccine includes live attenuated measles virus, which is detectable by PCR tests. No evidence exists of person-to-person transmission of measles vaccine virus, and illness does not typically result among immunocompetent persons...
March 28, 2024: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/38547026/association-between-leg-muscle-thickness-and-walking-test-with-the-haemophilia-specific-functional-parameters
#16
JOURNAL ARTICLE
Jia-Pei Hong, Jiunn-Horng Kang, Chian-Her Lee, Chih-Hong Lee, Shu-Huey Chen, Yen-Lin Liu, Jia-Ruey Tsai, Chen-Hua Tsai, Wan-Ling Ho, Mei-Mei Cheng, Prangthip Charoenpong, Chia-Yau Chang
OBJECTIVE: To evaluate the muscle thickness and walking test in people with haemophilia A (PWH) and their correlation to joint health and functional impairments. DESIGN: Cross-sectional study. RESULTS: 29 severe/moderate PWH were enrolled. Muscle thickness of quadriceps and medial gastrocnemius were measured using ultrasound. Joint health and functional capacity were assessed using Haemophilia Joint Health Score (HJHS), Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US), 6-Minute Walking test (6MWT), Haemophilia Quality of Life Questionnaire for Adults (Haem-A-QoL), and Haemophilia Activities List (HAL)...
March 26, 2024: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/38546965/comparable-rates-of-lumbar-disc-degeneration-at-long-term-following-adolescent-idiopathic-scoliosis-spinal-fusion-extended-to-l3-or-l4-systematic-review-and-meta-analysis
#17
REVIEW
Alberto Ruffilli, Matteo Traversari, Marco Manzetti, Giovanni Viroli, Elena Artioli, Simone Ottavio Zielli, Antonio Mazzotti, Cesare Faldini
PURPOSE: Surgical treatment of adolescent idiopathic scoliosis (AIS) requires a careful choice of fusion levels. The usual recommendation for the selection of the lowest instrumented vertebra (LIV) for double major or thoracolumbar/lumbar (TL/L) curves falls on L3 or L4. The aim of the present study is to assess if the spinal fusion with LIV selection of L3 or L4 in AIS patients has a clinical or radiological impact in terms of degenerative disc disease (DDD) in distal unfused segments at long-term follow-up...
March 28, 2024: Spine Deformity
https://read.qxmd.com/read/38546958/unveiling-urban-governance-diversity-clustering-cities-based-on-mitigation-actions
#18
JOURNAL ARTICLE
Sombol Mokhles, Kathryn Davidson, Michele Acuto
Embracing a "more global" urban comparison in scientific assessments of climate actions by cities is essential to drive greater and more inclusive participation in global efforts to curb climate change. This comparison needs to engage cities irrespective of their size and status: when we do so, distinctive patterns of urban climate mitigation actions across a diverse range of cities emerge. Employing K-means clustering as a pattern recognition method, this study compares cities based on selected aspects of their reported mitigation actions to the Carbon Disclosure Project...
March 28, 2024: Ambio
https://read.qxmd.com/read/38546928/biceps-brachii-elastography-in-well-trained-men-post-eccentric-exercise-induced-muscle-damage
#19
JOURNAL ARTICLE
Maria Clara Albuquerque Brandão, Lino de Azevedo Matias, Thiago Torres da Matta, Liliam Fernandes de Oliveira
PURPOSE: Recent advancements in elastography techniques, specifically supersonic shearwave elastography (SWE), have enabled non-invasive assessment of muscle stiffness. However, there is limited research on the immediate and short-term effects of eccentric exercise-induced muscle damage (EIMD) in well-trained individuals. This study aimed to follow up on the effects of eccentric training on the biceps brachialis stiffness by supersonic shearwave imaging (SSI) as well as the soreness and elbow flexion maximal voluntary isometric contraction (MVIC), immediately post-intervention, at 10 min, 48 h, and 96 h in well-trained men...
March 28, 2024: Journal of Ultrasound
https://read.qxmd.com/read/38546864/-artificial-intelligence-in-intensive-care-medicine
#20
REVIEW
André Baumgart, Grietje Beck, David Ghezel-Ahmadi
The integration of artificial intelligence (AI) into intensive care medicine has made considerable progress in recent studies, particularly in the areas of predictive analytics, early detection of complications, and the development of decision support systems. The main challenges remain availability and quality of data, reduction of bias and the need for explainable results from algorithms and models. Methods to explain these systems are essential to increase trust, understanding, and ethical considerations among healthcare professionals and patients...
March 28, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
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